OPTN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.01640911
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.01640911
3actin-myosin filament sliding (GO:0033275)5.88464931
4muscle filament sliding (GO:0030049)5.88464931
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.83521204
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.83394788
7L-phenylalanine metabolic process (GO:0006558)5.83394788
8sarcoplasmic reticulum calcium ion transport (GO:0070296)5.76303430
9aromatic amino acid family catabolic process (GO:0009074)5.27708869
10alpha-linolenic acid metabolic process (GO:0036109)5.26109697
11lysine metabolic process (GO:0006553)5.05431472
12lysine catabolic process (GO:0006554)5.05431472
13actin-mediated cell contraction (GO:0070252)4.99974919
14kynurenine metabolic process (GO:0070189)4.96943749
15regulation of triglyceride catabolic process (GO:0010896)4.95886844
16fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.87133865
17urea cycle (GO:0000050)4.86267852
18urea metabolic process (GO:0019627)4.86267852
19bile acid biosynthetic process (GO:0006699)4.77567458
20cysteine metabolic process (GO:0006534)4.75935889
21glyoxylate metabolic process (GO:0046487)4.75920224
22peptidyl-glutamic acid carboxylation (GO:0017187)4.73934376
23protein carboxylation (GO:0018214)4.73934376
24high-density lipoprotein particle remodeling (GO:0034375)4.73205905
25indole-containing compound catabolic process (GO:0042436)4.70502168
26indolalkylamine catabolic process (GO:0046218)4.70502168
27tryptophan catabolic process (GO:0006569)4.70502168
28positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.54817562
29amino-acid betaine metabolic process (GO:0006577)4.50611136
30sulfur amino acid catabolic process (GO:0000098)4.46595203
31nitrogen cycle metabolic process (GO:0071941)4.46308157
32tryptophan metabolic process (GO:0006568)4.46024139
33regulation of protein activation cascade (GO:2000257)4.38425002
34plasma lipoprotein particle clearance (GO:0034381)4.34617200
35reverse cholesterol transport (GO:0043691)4.33140630
36complement activation, alternative pathway (GO:0006957)4.33085828
37negative regulation of fibrinolysis (GO:0051918)4.31272421
38phospholipid efflux (GO:0033700)4.29383268
39triglyceride homeostasis (GO:0070328)4.29165287
40acylglycerol homeostasis (GO:0055090)4.29165287
41regulation of cholesterol esterification (GO:0010872)4.28713943
42serine family amino acid catabolic process (GO:0009071)4.23821595
43skeletal muscle contraction (GO:0003009)4.22249200
44regulation of skeletal muscle contraction (GO:0014819)4.19151546
45bile acid metabolic process (GO:0008206)4.18748082
46plasma lipoprotein particle remodeling (GO:0034369)4.15165473
47protein-lipid complex remodeling (GO:0034368)4.15165473
48macromolecular complex remodeling (GO:0034367)4.15165473
49regulation of complement activation (GO:0030449)4.12534536
50fatty acid beta-oxidation (GO:0006635)4.10913382
51phospholipid homeostasis (GO:0055091)4.07499434
52actin filament-based movement (GO:0030048)4.04827356
53regulation of fibrinolysis (GO:0051917)4.04436196
54cellular ketone body metabolic process (GO:0046950)4.03135451
55fatty acid transmembrane transport (GO:1902001)4.03081014
56negative regulation of sterol transport (GO:0032372)3.99874422
57negative regulation of cholesterol transport (GO:0032375)3.99874422
58homocysteine metabolic process (GO:0050667)3.98665019
592-oxoglutarate metabolic process (GO:0006103)3.96069665
60tyrosine metabolic process (GO:0006570)3.93875508
61positive regulation of lipid catabolic process (GO:0050996)3.91772423
62short-chain fatty acid metabolic process (GO:0046459)3.90997211
63fatty acid oxidation (GO:0019395)3.90573469
64alpha-amino acid catabolic process (GO:1901606)3.90017595
65aromatic amino acid family metabolic process (GO:0009072)3.89549159
66bile acid and bile salt transport (GO:0015721)3.88523770
67plasma lipoprotein particle assembly (GO:0034377)3.88045466
68coenzyme catabolic process (GO:0009109)3.87995552
69cholesterol efflux (GO:0033344)3.87578661
70aspartate family amino acid catabolic process (GO:0009068)3.87535444
71ethanol oxidation (GO:0006069)3.87532921
72fatty acid catabolic process (GO:0009062)3.86039670
73acetyl-CoA metabolic process (GO:0006084)3.85321576
74carnitine metabolic process (GO:0009437)3.84196612
75lipid oxidation (GO:0034440)3.83861021
76positive regulation of fatty acid beta-oxidation (GO:0032000)3.83246418
77carnitine shuttle (GO:0006853)3.76388042
78regulation of cholesterol homeostasis (GO:2000188)3.73872329
79positive regulation of triglyceride lipase activity (GO:0061365)3.69922381
80positive regulation of lipoprotein lipase activity (GO:0051006)3.69922381
81monocarboxylic acid catabolic process (GO:0072329)3.68987468
82flavonoid metabolic process (GO:0009812)3.67582983
83myofibril assembly (GO:0030239)3.63155093
84very-low-density lipoprotein particle assembly (GO:0034379)3.63038213
85glutamate metabolic process (GO:0006536)3.61802331
86cholesterol homeostasis (GO:0042632)3.61482978
87cellular amino acid catabolic process (GO:0009063)3.61001041
88regulation of bile acid biosynthetic process (GO:0070857)3.58782914
89ketone body metabolic process (GO:1902224)3.57999942
90protein-lipid complex assembly (GO:0065005)3.57395301
91dicarboxylic acid biosynthetic process (GO:0043650)3.56291778
92cellular glucuronidation (GO:0052695)3.56170014
93striated muscle contraction (GO:0006941)3.55027577
94sterol homeostasis (GO:0055092)3.54945436
95creatine metabolic process (GO:0006600)3.54270085
96regulation of relaxation of muscle (GO:1901077)3.53843237
97regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.50795529
98intestinal cholesterol absorption (GO:0030299)3.49520900
99drug catabolic process (GO:0042737)3.49399296
100regulation of cholesterol metabolic process (GO:0090181)3.49018810
101cofactor catabolic process (GO:0051187)3.47578671
102organic acid catabolic process (GO:0016054)3.46403662
103carboxylic acid catabolic process (GO:0046395)3.46403662
104glycine metabolic process (GO:0006544)3.45068901
105negative regulation of fatty acid biosynthetic process (GO:0045717)3.44283952
106indolalkylamine metabolic process (GO:0006586)3.44184950
107response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.44149974
108drug transmembrane transport (GO:0006855)3.42080045
109sarcomere organization (GO:0045214)3.41700120
110skeletal muscle adaptation (GO:0043501)3.40756290
111positive regulation of fatty acid oxidation (GO:0046321)3.39203357
112cellular modified amino acid catabolic process (GO:0042219)3.38685677
113positive regulation of triglyceride metabolic process (GO:0090208)3.35109040
114valine metabolic process (GO:0006573)3.34967860
115arginine metabolic process (GO:0006525)3.34832753
116plasma lipoprotein particle organization (GO:0071827)3.33432688
117response to inactivity (GO:0014854)3.27718088
118response to muscle activity (GO:0014850)3.11475439
119cardiac muscle contraction (GO:0060048)3.10007988
120regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.07444489
121plasma membrane repair (GO:0001778)3.06159004
122regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.96432954
123NADH metabolic process (GO:0006734)2.89277752
124muscle contraction (GO:0006936)2.88628921
125regulation of cell communication by electrical coupling (GO:0010649)2.87610684
126cardiac myofibril assembly (GO:0055003)2.82975351
127actomyosin structure organization (GO:0031032)2.80008832
128cellular response to epinephrine stimulus (GO:0071872)2.75279455
129skeletal muscle fiber development (GO:0048741)2.68715481
130regulation of necroptotic process (GO:0060544)2.67668096
131negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.63679426
132regulation of actin filament-based movement (GO:1903115)2.61843743
133muscle system process (GO:0003012)2.59338694
134striated muscle atrophy (GO:0014891)2.57525743
135negative regulation of necroptotic process (GO:0060546)2.56035783
136response to epinephrine (GO:0071871)2.53649531
137positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.52108033
138glycogen catabolic process (GO:0005980)2.52038964
139regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.46020470
140glucan catabolic process (GO:0009251)2.45522555
141regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.44956291
142regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.42028633
143skeletal muscle tissue development (GO:0007519)2.38072360
144negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.35303260
145negative regulation of cell killing (GO:0031342)2.35303260
146myotube cell development (GO:0014904)2.35030102
147cellular polysaccharide catabolic process (GO:0044247)2.33229964
148fructose metabolic process (GO:0006000)2.32867406
149positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.32123199
150striated muscle adaptation (GO:0014888)2.31349323
151barbed-end actin filament capping (GO:0051016)2.28906857
152positive regulation of myotube differentiation (GO:0010831)2.28213488
153adhesion of symbiont to host cell (GO:0044650)2.23644650
154virion attachment to host cell (GO:0019062)2.23644650
155regulation of membrane protein ectodomain proteolysis (GO:0051043)2.23611876
156cardiac muscle hypertrophy (GO:0003300)2.23180867
157regulation of striated muscle contraction (GO:0006942)2.23131973
158regulation of calcium ion transmembrane transporter activity (GO:1901019)2.21949661
159regulation of calcium ion transmembrane transport (GO:1903169)2.21949661
160positive regulation of receptor recycling (GO:0001921)2.20260687
161heart contraction (GO:0060047)2.18697452
162heart process (GO:0003015)2.18697452
163negative regulation of potassium ion transmembrane transport (GO:1901380)2.17849867
164regulation of the force of heart contraction (GO:0002026)2.14729819
165polysaccharide catabolic process (GO:0000272)2.12659221
166striated muscle hypertrophy (GO:0014897)2.12296001
167glucan biosynthetic process (GO:0009250)2.12045779
168glycogen biosynthetic process (GO:0005978)2.12045779
169muscle atrophy (GO:0014889)2.08919525
170regulation of sequestering of triglyceride (GO:0010889)2.08748487
171muscle cell cellular homeostasis (GO:0046716)2.08315626
172negative regulation of necrotic cell death (GO:0060547)2.08283950
173response to activity (GO:0014823)2.07310390
174negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.05654104
175regulation of necrotic cell death (GO:0010939)2.04735730
176negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.03495409
177negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.03413328
178muscle fiber development (GO:0048747)2.01960111
179negative regulation of calcium ion transmembrane transport (GO:1903170)2.01931285
180negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.01931285
181protein localization to endosome (GO:0036010)2.01262621
182muscle adaptation (GO:0043500)1.99600420
183cell adhesion mediated by integrin (GO:0033627)1.98565605
184negative regulation of protein localization to cell surface (GO:2000009)1.96820789
185membrane depolarization during cardiac muscle cell action potential (GO:0086012)1.95699042
186muscle hypertrophy (GO:0014896)1.94540979
187antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.94437915
188muscle tissue morphogenesis (GO:0060415)1.93353515
189cellular response to type I interferon (GO:0071357)1.92412337
190type I interferon signaling pathway (GO:0060337)1.92412337
191adhesion of symbiont to host (GO:0044406)1.91207927
192response to type I interferon (GO:0034340)1.91080404
193cardiac muscle tissue morphogenesis (GO:0055008)1.90312800
194positive regulation of mitochondrial calcium ion concentration (GO:0051561)1.89867638
195actin filament depolymerization (GO:0030042)1.88678271
196glycogen metabolic process (GO:0005977)1.88015593
197skin morphogenesis (GO:0043589)1.87644174
198regulation of syncytium formation by plasma membrane fusion (GO:0060142)1.87242937
199regulation of release of sequestered calcium ion into cytosol (GO:0051279)1.87035278

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.15685977
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.32239367
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.92531363
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.76451033
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.48374427
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.76959021
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.91817069
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.69581098
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.90974490
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.87047780
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.69646056
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.57775408
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.36472239
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.13107385
15* ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.0828619
16GATA1_22025678_ChIP-Seq_K562_Human1.99161934
17* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.95883602
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.91385367
19TP63_17297297_ChIP-ChIP_HaCaT_Human1.77755795
20CLOCK_20551151_ChIP-Seq_293T_Human1.71594342
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.67428044
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66111585
23* FOXA2_19822575_ChIP-Seq_HepG2_Human1.64457209
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.50198691
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49308358
26ZNF263_19887448_ChIP-Seq_K562_Human1.47501621
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.47465656
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45410921
29SOX2_27498859_Chip-Seq_STOMACH_Mouse1.40563486
30* HNF4A_19822575_ChIP-Seq_HepG2_Human1.39637191
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.36612330
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34698752
33CJUN_26792858_Chip-Seq_BT549_Human1.30684791
34RUNX_20019798_ChIP-Seq_JUKART_Human1.30683142
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30189559
36* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28306053
37SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23517088
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21066725
39ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15687189
40PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14791575
41RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14125449
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.12284660
43GATA1_19941827_ChIP-Seq_MEL_Mouse1.11994934
44DROSHA_22980978_ChIP-Seq_HELA_Human1.11282346
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10943412
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10465533
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10064015
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09734578
49HTT_18923047_ChIP-ChIP_STHdh_Human1.09560386
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09545817
51NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08040066
52JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07776045
53VDR_24787735_ChIP-Seq_THP-1_Human1.06889113
54RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06599018
55GATA4_25053715_ChIP-Seq_YYC3_Human1.06136911
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06123347
57TBX20_22080862_ChIP-Seq_HEART_Mouse1.05726516
58TBX20_22328084_ChIP-Seq_HEART_Mouse1.05726516
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.02872862
60STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.02310849
61* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01719964
62GATA1_19941826_ChIP-Seq_K562_Human1.01094041
63BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00290542
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00166224
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99081719
66GATA2_19941826_ChIP-Seq_K562_Human0.97485567
67ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97219847
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96615966
69DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94263798
70MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94101051
71JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93971750
72SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93663549
73FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.93439857
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93368574
75EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92289719
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92224147
77PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91146185
78ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90495791
79SOX2_20726797_ChIP-Seq_SW620_Human0.89876694
80SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.89153991
81SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.87917710
82SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.87666327
83P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87405158
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.87028150
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86273628
86STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86244719
87ELK3_25401928_ChIP-Seq_HUVEC_Human0.85648297
88SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85203842
89SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.84911538
90SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.84911538
91FOXO3_23340844_ChIP-Seq_DLD1_Human0.84646023
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84586322
93* RARA_24833708_ChIP-Seq_LIVER_Mouse0.84351483
94KDM2B_26808549_Chip-Seq_K562_Human0.84120391
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83931062
96KDM2B_26808549_Chip-Seq_DND41_Human0.83854347
97SMC1_22415368_ChIP-Seq_MEFs_Mouse0.82639665
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81927300
99* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.80509658
100* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.80387506
101SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.80354278
102SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80227653
103ESR1_20079471_ChIP-ChIP_T-47D_Human0.78740817
104TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.78737677
105WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.78007978
106SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77924291
107LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.77438289
108AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77399875
109EZH2_22144423_ChIP-Seq_EOC_Human0.77093129
110NR3C1_23031785_ChIP-Seq_PC12_Mouse0.76941484
111GATA6_25053715_ChIP-Seq_YYC3_Human0.76688480
112* SPI1_23127762_ChIP-Seq_K562_Human0.75691656
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.75426918
114MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.75081799
115CDX2_20551321_ChIP-Seq_CACO-2_Human0.74936529
116CTNNB1_20460455_ChIP-Seq_HCT116_Human0.74777710
117LXR_22292898_ChIP-Seq_THP-1_Human0.74755455
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72949275
119* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.72648410
120RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70503522
121AUTS2_25519132_ChIP-Seq_293T-REX_Human0.68391578
122* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.67348487
123BCOR_27268052_Chip-Seq_Bcells_Human0.66833223
124BRD4_27068464_Chip-Seq_AML-cells_Mouse0.66389293
125CDX2_19796622_ChIP-Seq_MESCs_Mouse0.66103014
126GATA1_22383799_ChIP-Seq_G1ME_Mouse0.65903607
127EGR1_19032775_ChIP-ChIP_M12_Human0.65431405
128PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.65082031
129PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.64969391
130GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.64469873
131EP300_21415370_ChIP-Seq_HL-1_Mouse0.64227371
132GATA2_21666600_ChIP-Seq_HMVEC_Human0.64044659
133BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63416426
134BCL6_27268052_Chip-Seq_Bcells_Human0.62910471
135* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.62762790
136SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.62621097
137RACK7_27058665_Chip-Seq_MCF-7_Human0.61816391
138FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.61678638
139PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.61433150
140* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.61072796
141CEBPB_22108803_ChIP-Seq_LS180_Human0.60853801
142PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.59338906
143ATF3_27146783_Chip-Seq_COLON_Human0.58766692
144ESET_19884257_ChIP-Seq_ESCs_Mouse0.58752362
145NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.58398102
146NRF2_20460467_ChIP-Seq_MEFs_Mouse0.58398102
147ESR1_21235772_ChIP-Seq_MCF-7_Human0.57960361
148EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.57820294
149KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.56965354
150FOXA1_25552417_ChIP-Seq_VCAP_Human0.56796044
151SPI1_20517297_ChIP-Seq_HL60_Human0.56446551
152GATA2_22383799_ChIP-Seq_G1ME_Mouse0.56103309
153CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.55817897
154KAP1_22055183_ChIP-Seq_ESCs_Mouse0.55341754
155NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.55336659
156* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.54301356
157SRY_22984422_ChIP-ChIP_TESTIS_Rat0.53579345

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.35914835
2MP0005360_urolithiasis6.48877458
3MP0005085_abnormal_gallbladder_physiolo5.48842039
4MP0005365_abnormal_bile_salt5.13034580
5MP0008875_abnormal_xenobiotic_pharmacok4.18861247
6MP0003806_abnormal_nucleotide_metabolis4.08329782
7MP0003252_abnormal_bile_duct3.52802665
8MP0004145_abnormal_muscle_electrophysio3.38488685
9MP0009840_abnormal_foam_cell3.35448048
10MP0010329_abnormal_lipoprotein_level3.32936020
11MP0004510_myositis2.79776552
12MP0001666_abnormal_nutrient_absorption2.64937234
13MP0008438_abnormal_cutaneous_collagen2.49736348
14MP0005083_abnormal_biliary_tract2.48620989
15MP0005332_abnormal_amino_acid2.34334021
16MP0003191_abnormal_cellular_cholesterol2.23829345
17MP0003195_calcinosis2.22280620
18MP0000759_abnormal_skeletal_muscle2.21401811
19MP0002106_abnormal_muscle_physiology2.17256762
20MP0002837_dystrophic_cardiac_calcinosis2.16398162
21MP0000609_abnormal_liver_physiology2.11952280
22MP0002118_abnormal_lipid_homeostasis2.09650981
23MP0005670_abnormal_white_adipose2.06103798
24MP0003656_abnormal_erythrocyte_physiolo2.05054155
25MP0003646_muscle_fatigue2.01631745
26MP0005319_abnormal_enzyme/_coenzyme1.94095005
27MP0004130_abnormal_muscle_cell1.88724825
28MP0002138_abnormal_hepatobiliary_system1.79932877
29MP0005369_muscle_phenotype1.79176258
30MP0003011_delayed_dark_adaptation1.72861829
31MP0004019_abnormal_vitamin_homeostasis1.72476934
32MP0000013_abnormal_adipose_tissue1.66854558
33MP0001764_abnormal_homeostasis1.66038388
34MP0000750_abnormal_muscle_regeneration1.65111879
35MP0001958_emphysema1.60210585
36MP0003303_peritoneal_inflammation1.58552208
37MP0003045_fibrosis1.55749832
38MP0005584_abnormal_enzyme/coenzyme_acti1.54787480
39MP0005666_abnormal_adipose_tissue1.47484328
40MP0003279_aneurysm1.46647539
41MP0003868_abnormal_feces_composition1.45212388
42MP0004233_abnormal_muscle_weight1.44693850
43MP0009780_abnormal_chondrocyte_physiolo1.43662524
44MP0004484_altered_response_of1.41092257
45MP0003300_gastrointestinal_ulcer1.39832070
46MP0006036_abnormal_mitochondrial_physio1.38765456
47MP0004270_analgesia1.38743451
48MP0005275_abnormal_skin_tensile1.38476052
49MP0000733_abnormal_muscle_development1.37628074
50MP0003705_abnormal_hypodermis_morpholog1.35762029
51MP0003091_abnormal_cell_migration1.28731343
52MP0009643_abnormal_urine_homeostasis1.27656162
53MP0003186_abnormal_redox_activity1.27198679
54MP0003879_abnormal_hair_cell1.25897439
55MP0006082_CNS_inflammation1.24392766
56MP0004147_increased_porphyrin_level1.23037453
57MP0003828_pulmonary_edema1.20696011
58MP0002971_abnormal_brown_adipose1.19976251
59MP0005166_decreased_susceptibility_to1.13075019
60MP0004084_abnormal_cardiac_muscle1.12557405
61MP0008260_abnormal_autophagy1.10935019
62MP0005330_cardiomyopathy1.09810716
63MP0003075_altered_response_to1.08142450
64MP0004036_abnormal_muscle_relaxation1.07703446
65MP0009785_altered_susceptibility_to1.07520555
66MP0009697_abnormal_copulation1.06347441
67MP0000598_abnormal_liver_morphology1.05261348
68MP0000003_abnormal_adipose_tissue1.05258849
69MP0002108_abnormal_muscle_morphology1.04362201
70MP0001542_abnormal_bone_strength1.03759710
71MP0002269_muscular_atrophy1.03521851
72MP0004215_abnormal_myocardial_fiber1.01930902
73MP0000751_myopathy0.98153879
74MP0009764_decreased_sensitivity_to0.97613518
75MP0005451_abnormal_body_composition0.97452466
76MP0003436_decreased_susceptibility_to0.97079944
77MP0000604_amyloidosis0.96206460
78MP0000749_muscle_degeneration0.95349994
79MP0003566_abnormal_cell_adhesion0.95297731
80MP0005165_increased_susceptibility_to0.94415212
81MP0005266_abnormal_metabolism0.94146514
82MP0002078_abnormal_glucose_homeostasis0.93879388
83MP0004272_abnormal_basement_membrane0.93700198
84MP0009763_increased_sensitivity_to0.92640744
85MP0005636_abnormal_mineral_homeostasis0.91647493
86MP0005334_abnormal_fat_pad0.91301632
87MP0008775_abnormal_heart_ventricle0.90466707
88MP0008874_decreased_physiological_sensi0.89207784
89MP0001533_abnormal_skeleton_physiology0.88847626
90MP0008469_abnormal_protein_level0.87892539
91MP0005376_homeostasis/metabolism_phenot0.87247305
92MP0004087_abnormal_muscle_fiber0.86837280
93MP0005023_abnormal_wound_healing0.86704367
94MP0001790_abnormal_immune_system0.84881861
95MP0005387_immune_system_phenotype0.84881861
96MP0002998_abnormal_bone_remodeling0.84773887
97MP0002127_abnormal_cardiovascular_syste0.84707769
98MP0000685_abnormal_immune_system0.84550445
99MP0004185_abnormal_adipocyte_glucose0.84037684
100MP0009642_abnormal_blood_homeostasis0.83072377
101MP0005647_abnormal_sex_gland0.82045746
102MP0005535_abnormal_body_temperature0.81850081
103MP0005375_adipose_tissue_phenotype0.81845822
104MP0005164_abnormal_response_to0.80908115
105MP0002148_abnormal_hypersensitivity_rea0.80540063
106MP0006035_abnormal_mitochondrial_morpho0.80451426
107MP0005595_abnormal_vascular_smooth0.78931742
108MP0002896_abnormal_bone_mineralization0.78780188
109MP0010368_abnormal_lymphatic_system0.78254520
110MP0000249_abnormal_blood_vessel0.75816147
111MP0000920_abnormal_myelination0.75324289
112MP0005448_abnormal_energy_balance0.74198623
113MP0004947_skin_inflammation0.73179402
114MP0002933_joint_inflammation0.71885153
115MP0003221_abnormal_cardiomyocyte_apopto0.71612999
116MP0005385_cardiovascular_system_phenoty0.71465496
117MP0001544_abnormal_cardiovascular_syste0.71465496
118MP0009115_abnormal_fat_cell0.70932287
119MP0003950_abnormal_plasma_membrane0.69747753
120MP0001501_abnormal_sleep_pattern0.69234939
121MP0010630_abnormal_cardiac_muscle0.68275857
122MP0003453_abnormal_keratinocyte_physiol0.67728945
123MP0005503_abnormal_tendon_morphology0.67284923
124MP0002972_abnormal_cardiac_muscle0.66076704
125MP0005025_abnormal_response_to0.65402024
126MP0005410_abnormal_fertilization0.65046711
127MP0002822_catalepsy0.62576578
128MP0002254_reproductive_system_inflammat0.60171657
129MP0005620_abnormal_muscle_contractility0.59793054
130MP0006138_congestive_heart_failure0.59715844
131MP0002332_abnormal_exercise_endurance0.58785021
132MP0000747_muscle_weakness0.56697331
133MP0000230_abnormal_systemic_arterial0.56554675
134MP0004043_abnormal_pH_regulation0.55159556
135MP0002970_abnormal_white_adipose0.54945288
136MP0001853_heart_inflammation0.54054250
137MP0001756_abnormal_urination0.53944696
138MP0003724_increased_susceptibility_to0.53742192
139MP0009765_abnormal_xenobiotic_induced0.53584286
140MP0005167_abnormal_blood-brain_barrier0.53495018
141MP0003690_abnormal_glial_cell0.53441541
142MP0005408_hypopigmentation0.53343821
143MP0005084_abnormal_gallbladder_morpholo0.53058154
144MP0001661_extended_life_span0.52640667
145MP0000343_altered_response_to0.49211650
146MP0002136_abnormal_kidney_physiology0.48882215
147MP0005058_abnormal_lysosome_morphology0.48849596
148MP0008961_abnormal_basal_metabolism0.48769664
149MP0003329_amyloid_beta_deposits0.48567028
150MP0002876_abnormal_thyroid_physiology0.48258010
151MP0001324_abnormal_eye_pigmentation0.46841844
152MP0005464_abnormal_platelet_physiology0.43861545
153MP0002090_abnormal_vision0.43836391
154MP0003953_abnormal_hormone_level0.43267635

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)7.65327651
2Nemaline bodies (HP:0003798)7.63744211
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.43366620
4Type 1 muscle fiber predominance (HP:0003803)6.66472583
5Intrahepatic cholestasis (HP:0001406)6.41436500
6Deep venous thrombosis (HP:0002625)5.62807191
7Abnormality of aromatic amino acid family metabolism (HP:0004338)5.50172871
8Abnormality of monocarboxylic acid metabolism (HP:0010996)5.50024383
9Xanthomatosis (HP:0000991)5.34436417
10Hypobetalipoproteinemia (HP:0003563)5.25152317
11Prolonged partial thromboplastin time (HP:0003645)4.73927072
12Hyperlipoproteinemia (HP:0010980)4.53743302
13Hyperammonemia (HP:0001987)4.40296157
14Muscle fiber splitting (HP:0003555)4.37981181
15Hypolipoproteinemia (HP:0010981)4.36066338
16Ketosis (HP:0001946)4.21879583
17EMG: myopathic abnormalities (HP:0003458)4.14580135
18Hypoglycemic coma (HP:0001325)4.13187091
19Hypoalphalipoproteinemia (HP:0003233)4.10535732
20Complement deficiency (HP:0004431)4.10092976
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.99094972
22Abnormality of skeletal muscle fiber size (HP:0012084)3.98162425
23Myopathic facies (HP:0002058)3.89024266
24Epidermoid cyst (HP:0200040)3.88442768
25Muscle hypertrophy of the lower extremities (HP:0008968)3.88232538
26Abnormality of fatty-acid metabolism (HP:0004359)3.86305674
27Hyperglycinuria (HP:0003108)3.83639886
28Abnormality of glutamine family amino acid metabolism (HP:0010902)3.82126626
29Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.75974784
30Distal arthrogryposis (HP:0005684)3.72280746
31Increased variability in muscle fiber diameter (HP:0003557)3.71115656
32Increased connective tissue (HP:0009025)3.68823267
33Neck muscle weakness (HP:0000467)3.62794182
34Centrally nucleated skeletal muscle fibers (HP:0003687)3.62769496
35Abnormality of glycine metabolism (HP:0010895)3.61397741
36Abnormality of serine family amino acid metabolism (HP:0010894)3.61397741
37Asymmetric septal hypertrophy (HP:0001670)3.61003369
38Hyperglycinemia (HP:0002154)3.54846080
39Round ear (HP:0100830)3.52631708
40Calf muscle hypertrophy (HP:0008981)3.51421638
41Abnormality of the common coagulation pathway (HP:0010990)3.50230818
42Abnormality of the calf musculature (HP:0001430)3.46670731
43Abnormality of sulfur amino acid metabolism (HP:0004339)3.46599194
44Hypercholesterolemia (HP:0003124)3.46480236
45Acanthocytosis (HP:0001927)3.44126558
46Ketoacidosis (HP:0001993)3.43235711
47Fat malabsorption (HP:0002630)3.43069216
48Abnormality of aspartate family amino acid metabolism (HP:0010899)3.40026996
49Joint hemorrhage (HP:0005261)3.38701703
50Ulnar deviation of the wrist (HP:0003049)3.36462679
51Distal lower limb muscle weakness (HP:0009053)3.34905947
52Difficulty running (HP:0009046)3.29816016
53Myoglobinuria (HP:0002913)3.28494272
54Abnormality of methionine metabolism (HP:0010901)3.25181971
55Hyperbilirubinemia (HP:0002904)3.20792750
56Abnormality of dicarboxylic acid metabolism (HP:0010995)3.09768193
57Dicarboxylic aciduria (HP:0003215)3.09768193
58Frequent falls (HP:0002359)3.09688230
59Cholelithiasis (HP:0001081)3.07394412
60Abnormal gallbladder physiology (HP:0012438)3.06465989
61Cholecystitis (HP:0001082)3.06465989
62Abnormal gallbladder morphology (HP:0012437)2.96724335
63Bundle branch block (HP:0011710)2.94857304
64Abnormality of complement system (HP:0005339)2.91713364
65Poikilocytosis (HP:0004447)2.90716323
66Abnormality of the intrinsic pathway (HP:0010989)2.90643576
67Mildly elevated creatine phosphokinase (HP:0008180)2.90225997
68Metabolic acidosis (HP:0001942)2.88417714
69Rimmed vacuoles (HP:0003805)2.77118828
70Subaortic stenosis (HP:0001682)2.77027030
71Abnormality of the left ventricular outflow tract (HP:0011103)2.77027030
72Conjugated hyperbilirubinemia (HP:0002908)2.76191106
73Skin nodule (HP:0200036)2.73360471
74Distal lower limb amyotrophy (HP:0008944)2.72638174
75Rhabdomyolysis (HP:0003201)2.71271358
76Slender build (HP:0001533)2.68961934
77Polycythemia (HP:0001901)2.68068239
78Muscle stiffness (HP:0003552)2.67813666
79Myocardial infarction (HP:0001658)2.66506429
80Spinal rigidity (HP:0003306)2.62933557
81Protrusio acetabuli (HP:0003179)2.62409446
82Abnormality of pyrimidine metabolism (HP:0004353)2.56813739
83Abnormality of nucleobase metabolism (HP:0010932)2.53830486
84Abnormality of purine metabolism (HP:0004352)2.52338859
85Reticulocytosis (HP:0001923)2.50677933
86Lethargy (HP:0001254)2.50252468
87Hepatocellular carcinoma (HP:0001402)2.50089278
88Abnormality of serum amino acid levels (HP:0003112)2.48782250
89Cerebral edema (HP:0002181)2.47190733
90Exercise-induced myalgia (HP:0003738)2.43288670
91Pigmentary retinal degeneration (HP:0001146)2.41770274
92Abnormality of the gallbladder (HP:0005264)2.36135017
93EMG: neuropathic changes (HP:0003445)2.35550168
94Steatorrhea (HP:0002570)2.35212151
95Hyperinsulinemic hypoglycemia (HP:0000825)2.32886093
96Abnormality of proline metabolism (HP:0010907)2.32810188
97Hydroxyprolinuria (HP:0003080)2.32810188
98Sensorimotor neuropathy (HP:0007141)2.31437611
99Difficulty climbing stairs (HP:0003551)2.29542834
100Hypochromic microcytic anemia (HP:0004840)2.24973117
101Right ventricular cardiomyopathy (HP:0011663)2.22685677
102Nausea (HP:0002018)2.22048206
103Scapular winging (HP:0003691)2.20956700
104Delayed CNS myelination (HP:0002188)2.20755270
105Generalized aminoaciduria (HP:0002909)2.20329693
106Malnutrition (HP:0004395)2.19499751
107Late onset (HP:0003584)2.18362117
108Systemic lupus erythematosus (HP:0002725)2.16732089
109Hypoglycemic seizures (HP:0002173)2.16258696
110Foot dorsiflexor weakness (HP:0009027)2.16255114
111Myotonia (HP:0002486)2.15986480
112Vomiting (HP:0002013)2.15843181
113Bulbar palsy (HP:0001283)2.15700020
114Aortic aneurysm (HP:0004942)2.14508810
115Lower limb amyotrophy (HP:0007210)2.14480082
116Calcaneovalgus deformity (HP:0001848)2.14332221
117Vascular calcification (HP:0004934)2.14290860
118Spontaneous abortion (HP:0005268)2.12551931
119Abnormality of iron homeostasis (HP:0011031)2.11976396
120Lipoatrophy (HP:0100578)2.11148962
121Exercise-induced muscle cramps (HP:0003710)2.10963501
122Abnormality of the foot musculature (HP:0001436)2.10406936
123Vascular tortuosity (HP:0004948)2.09365725
124Gout (HP:0001997)2.09221584
125Abnormality of transition element cation homeostasis (HP:0011030)2.08772167
126Absent phalangeal crease (HP:0006109)2.08551816
127Abnormal atrioventricular conduction (HP:0005150)2.06920370
128Malignant hyperthermia (HP:0002047)2.06698223
129Renal cortical cysts (HP:0000803)2.06077942
130Brushfield spots (HP:0001088)2.05606843
131Hemorrhage of the eye (HP:0011885)2.05404356
132Hyporeflexia of lower limbs (HP:0002600)2.05014459
133Generalized muscle weakness (HP:0003324)2.03968353
134Dilated cardiomyopathy (HP:0001644)2.03899515
135Gowers sign (HP:0003391)2.03814300
136Hypertriglyceridemia (HP:0002155)2.02546632
137Esophageal varix (HP:0002040)2.02483743
138Limb-girdle muscle atrophy (HP:0003797)2.02170811
139Pancreatitis (HP:0001733)2.00156846
140Heart block (HP:0012722)1.99996376
141Premature rupture of membranes (HP:0001788)1.98429917
142Arterial tortuosity (HP:0005116)1.97066384
143Amyloidosis (HP:0011034)1.96942855
144Increased serum ferritin (HP:0003281)1.95389623
145Abnormality of glycosphingolipid metabolism (HP:0004343)1.94329188
146Abnormality of glycolipid metabolism (HP:0010969)1.94329188
147Abnormality of liposaccharide metabolism (HP:0010968)1.94329188
148Fetal akinesia sequence (HP:0001989)1.94148946
149Deformed tarsal bones (HP:0008119)1.91840971
150Cardiovascular calcification (HP:0011915)1.91819563
151Hyperglycemia (HP:0003074)1.91354993
152Areflexia of lower limbs (HP:0002522)1.91302157
153Neonatal onset (HP:0003623)1.90370272
154Sudden death (HP:0001699)1.89451823
155Recurrent gram-negative bacterial infections (HP:0005420)1.88298696
156Glomerulonephritis (HP:0000099)1.87676116
157Palpitations (HP:0001962)1.87069163
158Increased muscle lipid content (HP:0009058)1.86911064
159Cerebral inclusion bodies (HP:0100314)1.85201971
160Abnormal cartilage morphology (HP:0002763)1.84079177
161Ventricular tachycardia (HP:0004756)1.83436375
162Muscular dystrophy (HP:0003560)1.82996724
163Ventricular arrhythmia (HP:0004308)1.82212374
164Hyperkalemia (HP:0002153)1.81826129
165Neurofibrillary tangles (HP:0002185)1.80941698
166Aortic dissection (HP:0002647)1.75942771
167Atrophic scars (HP:0001075)1.72686917
168Limb-girdle muscle weakness (HP:0003325)1.72029432
169Abnormal finger flexion creases (HP:0006143)1.71868894
170Atrioventricular block (HP:0001678)1.68432593
171Cerebral aneurysm (HP:0004944)1.67085031
172Hip contracture (HP:0003273)1.66514954
173Peritonitis (HP:0002586)1.66103441
174Achilles tendon contracture (HP:0001771)1.64630572
175Weak cry (HP:0001612)1.64577086
176Vertebral compression fractures (HP:0002953)1.63648970
177Axonal loss (HP:0003447)1.63400967
178Waddling gait (HP:0002515)1.61272592
179Abnormality of the Achilles tendon (HP:0005109)1.58248285
180Rapidly progressive (HP:0003678)1.57135655
181Abnormality of the musculature of the pelvis (HP:0001469)1.55307506
182Abnormality of the hip-girdle musculature (HP:0001445)1.55307506
183Fatigable weakness (HP:0003473)1.54715420
184Abnormality of the neuromuscular junction (HP:0003398)1.54715420
185Facial diplegia (HP:0001349)1.51305694
186Proximal amyotrophy (HP:0007126)1.45802653
187Aneurysm (HP:0002617)1.45224511
188Ventricular fibrillation (HP:0001663)1.44772850
189Atrial fibrillation (HP:0005110)1.44479468

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.80008615
2PDK33.18299952
3PDK43.18299952
4TRIB33.13776302
5SIK12.92057742
6ERN12.86178225
7PKN22.51643355
8TTN2.51602018
9TAOK32.46057248
10FGFR42.32580144
11PDK22.17703376
12MST1R2.04884442
13INSRR1.99855405
14OBSCN1.97144449
15LMTK21.86060765
16PRPF4B1.73260100
17PINK11.72413992
18PHKG21.57259548
19PHKG11.57259548
20PTK61.51686563
21MOS1.48368524
22ERBB41.46936668
23* TBK11.46374877
24TRPM71.45949039
25RIPK11.44725253
26MAP3K71.43303686
27PRKAA21.43204672
28FLT31.41585551
29TAOK21.39584832
30PIK3CG1.39001211
31MARK11.37878784
32STK31.35166031
33MAP3K131.35029983
34TYK21.30153094
35DDR21.29876934
36NEK91.28573905
37MAP2K31.27417881
38MAPK111.22853686
39IKBKE1.22620126
40MAP2K41.22031021
41NEK11.21846410
42LIMK11.19369243
43CAMK1D1.18901548
44CDC42BPA1.16914440
45PRKAA11.16779513
46MAP3K101.15233820
47MYLK1.13419063
48GRK71.12193664
49PBK1.12058793
50STK241.09369966
51TESK11.08699001
52FRK1.05121356
53PDPK11.04650739
54ICK1.02145245
55GRK61.00754675
56JAK21.00477086
57STK380.99925590
58MAPKAPK30.99341249
59ZAP700.95659416
60KSR20.94450650
61PAK60.94034351
62IRAK30.93781144
63PIK3CA0.92753830
64JAK10.92346837
65TIE10.91755005
66KDR0.88866299
67FGFR30.86997827
68LATS20.86960519
69LATS10.85706327
70MAP3K110.84948444
71ARAF0.84561725
72ABL20.83682630
73DMPK0.83608927
74MAP3K30.82840214
75GRK50.81481384
76MAPK70.80404663
77PDK10.76636355
78ROCK10.76402540
79PRKACG0.76191322
80MAPK120.75906065
81JAK30.75905769
82PRKG20.75831936
83PTK2B0.73862209
84NTRK10.72717103
85MAP3K120.71501130
86MAP3K50.69227490
87MATK0.67562387
88TAOK10.65844441
89GRK10.65839037
90MARK20.65436967
91EPHA30.64093430
92EPHB10.63435467
93MAP3K140.63393643
94CAMK1G0.62130952
95MET0.60560523
96CDK60.60113796
97MTOR0.58338290
98PIM20.58181003
99SGK20.57553510
100PRKD10.56837418
101CAMK2D0.56711043
102DYRK1B0.56516142
103MAPK40.56308637
104MAP2K10.53601994
105CAMK2B0.53450886
106TXK0.51883745
107ERBB20.51358794
108ROCK20.50804878
109PRKD20.50497139
110SIK20.49767838
111STK40.49698309
112DAPK30.49002716
113PDGFRB0.48636602
114SGK2230.48374631
115SGK4940.48374631
116MUSK0.48264157
117TGFBR20.47772823
118DAPK20.47572455
119MAP2K20.47476893
120CAMK2A0.47402953
121PAK30.47046003
122CSK0.46511445
123RIPK40.46085004
124KSR10.45965927
125MAP3K20.45069500
126CAMK2G0.44794895
127IKBKB0.43738482
128STK38L0.42954355
129CAMK40.42624500
130EPHB20.42087476
131PKN10.41477540
132RET0.40542285
133GSK3A0.40531689
134WNK10.39085012
135CAMK10.38846395
136SGK30.38794715
137CDK40.38716559
138MAPK150.37811377
139MAP2K60.35827821
140WNK40.35432669
141ZAK0.33843198
142PRKCZ0.33786182
143PDGFRA0.33734546
144MAP3K10.33580389
145MAP3K60.33489869
146KIT0.33324480
147TTK0.32458143
148PTK20.30901147

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.73034373
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.35513969
3Fatty acid degradation_Homo sapiens_hsa000713.02839921
4Nitrogen metabolism_Homo sapiens_hsa009102.98502253
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.86028623
6Arginine biosynthesis_Homo sapiens_hsa002202.78402980
7Tryptophan metabolism_Homo sapiens_hsa003802.63005358
8Propanoate metabolism_Homo sapiens_hsa006402.59764730
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.58449837
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.56137882
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.27477479
12PPAR signaling pathway_Homo sapiens_hsa033202.26711005
13Complement and coagulation cascades_Homo sapiens_hsa046102.24152700
14Fatty acid metabolism_Homo sapiens_hsa012122.23897007
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.17662683
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.01157809
17Caffeine metabolism_Homo sapiens_hsa002321.98668826
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.98066330
19Butanoate metabolism_Homo sapiens_hsa006501.97591452
20Peroxisome_Homo sapiens_hsa041461.96136491
21Pyruvate metabolism_Homo sapiens_hsa006201.88582370
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.87913057
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.73998011
24Fat digestion and absorption_Homo sapiens_hsa049751.70184447
25beta-Alanine metabolism_Homo sapiens_hsa004101.68690431
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.68472166
27Carbon metabolism_Homo sapiens_hsa012001.66987134
28Starch and sucrose metabolism_Homo sapiens_hsa005001.63001990
29Histidine metabolism_Homo sapiens_hsa003401.61185102
30Bile secretion_Homo sapiens_hsa049761.54109300
31Chemical carcinogenesis_Homo sapiens_hsa052041.53799788
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.51213698
33Selenocompound metabolism_Homo sapiens_hsa004501.50570613
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46904713
35Circadian rhythm_Homo sapiens_hsa047101.41188390
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40944862
37ABC transporters_Homo sapiens_hsa020101.40934772
38Phenylalanine metabolism_Homo sapiens_hsa003601.40356970
39Retinol metabolism_Homo sapiens_hsa008301.38106503
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.37342035
41Staphylococcus aureus infection_Homo sapiens_hsa051501.37121417
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36887053
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.36879042
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.30987137
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30773345
46Tyrosine metabolism_Homo sapiens_hsa003501.29506280
47Sulfur metabolism_Homo sapiens_hsa009201.28215097
48Biosynthesis of amino acids_Homo sapiens_hsa012301.27865921
49Fatty acid elongation_Homo sapiens_hsa000621.25964314
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24597464
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.20452916
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.19834044
53Folate biosynthesis_Homo sapiens_hsa007901.15579607
54Oxytocin signaling pathway_Homo sapiens_hsa049211.12544956
55Focal adhesion_Homo sapiens_hsa045101.12157687
56Malaria_Homo sapiens_hsa051441.10976753
57Osteoclast differentiation_Homo sapiens_hsa043801.08449836
58Other glycan degradation_Homo sapiens_hsa005111.08120474
59Long-term potentiation_Homo sapiens_hsa047201.07210252
60Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06126854
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05191048
62GnRH signaling pathway_Homo sapiens_hsa049121.03804270
63Fatty acid biosynthesis_Homo sapiens_hsa000611.02308682
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02033762
65Pertussis_Homo sapiens_hsa051331.01826571
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01354383
67Renin secretion_Homo sapiens_hsa049240.99462214
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99164566
69Glycerolipid metabolism_Homo sapiens_hsa005610.98937061
70TNF signaling pathway_Homo sapiens_hsa046680.98489465
71Vitamin B6 metabolism_Homo sapiens_hsa007500.95641315
72Vitamin digestion and absorption_Homo sapiens_hsa049770.93964452
73Arginine and proline metabolism_Homo sapiens_hsa003300.92947198
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.91947964
75Calcium signaling pathway_Homo sapiens_hsa040200.88713204
76Lysine degradation_Homo sapiens_hsa003100.86940810
77Pentose phosphate pathway_Homo sapiens_hsa000300.86765678
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84778038
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84615314
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83324181
81Sulfur relay system_Homo sapiens_hsa041220.82738648
82Galactose metabolism_Homo sapiens_hsa000520.82424770
83Steroid biosynthesis_Homo sapiens_hsa001000.82167330
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78330275
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.77992976
86VEGF signaling pathway_Homo sapiens_hsa043700.77322313
87ECM-receptor interaction_Homo sapiens_hsa045120.77186768
88Viral myocarditis_Homo sapiens_hsa054160.77015331
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.76765144
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.75300837
91Fructose and mannose metabolism_Homo sapiens_hsa000510.73393922
92Gastric acid secretion_Homo sapiens_hsa049710.72614639
93Lysosome_Homo sapiens_hsa041420.71604023
94Toxoplasmosis_Homo sapiens_hsa051450.71060501
95African trypanosomiasis_Homo sapiens_hsa051430.70091857
96Salmonella infection_Homo sapiens_hsa051320.68921722
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.68478418
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67925978
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.67597268
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.67346731
101Tuberculosis_Homo sapiens_hsa051520.65929111
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65058849
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.64369592
104Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62657470
105Renal cell carcinoma_Homo sapiens_hsa052110.62403870
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62395190
107Platelet activation_Homo sapiens_hsa046110.61840893
108Glutathione metabolism_Homo sapiens_hsa004800.60929502
109T cell receptor signaling pathway_Homo sapiens_hsa046600.60659755
110Leishmaniasis_Homo sapiens_hsa051400.60245760
111Insulin secretion_Homo sapiens_hsa049110.60109519
112Dorso-ventral axis formation_Homo sapiens_hsa043200.59459132
113Synaptic vesicle cycle_Homo sapiens_hsa047210.59144551
114Prolactin signaling pathway_Homo sapiens_hsa049170.58291686
115MAPK signaling pathway_Homo sapiens_hsa040100.57037815
116FoxO signaling pathway_Homo sapiens_hsa040680.56497576
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55234502
118Insulin resistance_Homo sapiens_hsa049310.54050788
119Chemokine signaling pathway_Homo sapiens_hsa040620.52360629
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51752493
121Proteoglycans in cancer_Homo sapiens_hsa052050.51682457
122Endocytosis_Homo sapiens_hsa041440.49838962
123Rheumatoid arthritis_Homo sapiens_hsa053230.49195228
124Glioma_Homo sapiens_hsa052140.49117040
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48520810
126Metabolic pathways_Homo sapiens_hsa011000.48245363
127Amphetamine addiction_Homo sapiens_hsa050310.47704033
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.47495033
129Circadian entrainment_Homo sapiens_hsa047130.46995011
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.46430764
131Salivary secretion_Homo sapiens_hsa049700.45009650
132Tight junction_Homo sapiens_hsa045300.44659751
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44204947
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43615654
135Influenza A_Homo sapiens_hsa051640.43403080
136mTOR signaling pathway_Homo sapiens_hsa041500.42984626
137One carbon pool by folate_Homo sapiens_hsa006700.42359933
138Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41871668
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39013517
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38820517
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.37993541
142Glucagon signaling pathway_Homo sapiens_hsa049220.36349123
143AMPK signaling pathway_Homo sapiens_hsa041520.33271590
144Linoleic acid metabolism_Homo sapiens_hsa005910.28378806
145Insulin signaling pathway_Homo sapiens_hsa049100.21101758
146Renin-angiotensin system_Homo sapiens_hsa046140.20626893
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.16818275
148Mineral absorption_Homo sapiens_hsa049780.15164309
149Central carbon metabolism in cancer_Homo sapiens_hsa052300.09380581
150Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08347325
151Cardiac muscle contraction_Homo sapiens_hsa042600.07444781
152Prion diseases_Homo sapiens_hsa050200.06975218
153Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.01647700
154Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.00108867
155Protein digestion and absorption_Homo sapiens_hsa04974-0.1370086
156RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1243643
157Amoebiasis_Homo sapiens_hsa05146-0.0979835
158Hepatitis C_Homo sapiens_hsa05160-0.0878875
159Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0869928
160Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0747272
161Alzheimers disease_Homo sapiens_hsa05010-0.0704082
162Phototransduction_Homo sapiens_hsa04744-0.0652864
163Dilated cardiomyopathy_Homo sapiens_hsa05414-0.0606166
164Oxidative phosphorylation_Homo sapiens_hsa00190-0.0335193
165Type II diabetes mellitus_Homo sapiens_hsa04930-0.0332832
166Parkinsons disease_Homo sapiens_hsa05012-0.0152060

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