ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of memory T cell differentiation (GO:0043380)	6.68769801
2	fucose catabolic process (GO:0019317)	6.05998507
3	L-fucose metabolic process (GO:0042354)	6.05998507
4	L-fucose catabolic process (GO:0042355)	6.05998507
5	regulation of establishment of cell polarity (GO:2000114)	5.32787782
6	cellular ketone body metabolic process (GO:0046950)	4.90688971
7	regulation of MHC class I biosynthetic process (GO:0045343)	4.84573662
8	cholesterol catabolic process (GO:0006707)	4.81572474
9	sterol catabolic process (GO:0016127)	4.81572474
10	negative regulation of type 2 immune response (GO:0002829)	4.55756118
11	vitamin transmembrane transport (GO:0035461)	4.47161980
12	kynurenine metabolic process (GO:0070189)	4.35480421
13	regulation of meiosis I (GO:0060631)	4.33183152
14	ketone body metabolic process (GO:1902224)	4.30434415
15	parturition (GO:0007567)	4.26496536
16	behavioral response to nicotine (GO:0035095)	4.22462441
17	ADP metabolic process (GO:0046031)	4.18896522
18	regulation of establishment or maintenance of cell polarity (GO:0032878)	4.11323888
19	indolalkylamine metabolic process (GO:0006586)	4.07766728
20	bile acid biosynthetic process (GO:0006699)	4.04548076
21	negative regulation of multicellular organism growth (GO:0040015)	4.04233593
22	negative regulation of mast cell activation (GO:0033004)	4.00301311
23	positive regulation of triglyceride biosynthetic process (GO:0010867)	3.83139464
24	sex differentiation (GO:0007548)	3.80908510
25	organic cation transport (GO:0015695)	3.78707829
26	tryptophan catabolic process (GO:0006569)	3.76603997
27	indole-containing compound catabolic process (GO:0042436)	3.76603997
28	indolalkylamine catabolic process (GO:0046218)	3.76603997
29	cytoplasmic mRNA processing body assembly (GO:0033962)	3.69508740
30	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.68660186
31	regulation of sequestering of triglyceride (GO:0010889)	3.56944835
32	dopamine transport (GO:0015872)	3.56395691
33	positive regulation of vasculogenesis (GO:2001214)	3.52380183
34	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.50815264
35	regulation of triglyceride catabolic process (GO:0010896)	3.49623037
36	retinal cone cell development (GO:0046549)	3.47455478
37	cilium or flagellum-dependent cell motility (GO:0001539)	3.47446705
38	auditory receptor cell stereocilium organization (GO:0060088)	3.46440230
39	detection of light stimulus involved in visual perception (GO:0050908)	3.43645801
40	detection of light stimulus involved in sensory perception (GO:0050962)	3.43645801
41	negative regulation of Rho protein signal transduction (GO:0035024)	3.42806448
42	primary amino compound metabolic process (GO:1901160)	3.39279768
43	somite rostral/caudal axis specification (GO:0032525)	3.36730025
44	synaptic transmission, cholinergic (GO:0007271)	3.33367599
45	cAMP catabolic process (GO:0006198)	3.29890467
46	tryptophan metabolic process (GO:0006568)	3.29790384
47	neural tube formation (GO:0001841)	3.29705055
48	protein prenylation (GO:0018342)	3.27630037
49	prenylation (GO:0097354)	3.27630037
50	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.24277338
51	positive regulation of meiosis (GO:0045836)	3.23567127
52	cerebellar Purkinje cell differentiation (GO:0021702)	3.20974295
53	fucosylation (GO:0036065)	3.16532419
54	meiotic chromosome segregation (GO:0045132)	3.13840390
55	stress granule assembly (GO:0034063)	3.13233597
56	regulation of triglyceride biosynthetic process (GO:0010866)	3.11609016
57	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.11596248
58	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.03731490
59	detection of chemical stimulus involved in sensory perception (GO:0050907)	3.02298856
60	photoreceptor cell maintenance (GO:0045494)	3.01777392
61	histone H3-K4 trimethylation (GO:0080182)	3.01238283
62	positive regulation of meiotic cell cycle (GO:0051446)	2.99701062
63	regulation of vasculogenesis (GO:2001212)	2.98903564
64	indole-containing compound metabolic process (GO:0042430)	2.94051691
65	azole transport (GO:0045117)	2.92628181
66	neuronal action potential propagation (GO:0019227)	2.92114955
67	lipid particle organization (GO:0034389)	2.90400284
68	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.84933471
69	platelet dense granule organization (GO:0060155)	2.84359538
70	reflex (GO:0060004)	2.83806475
71	centrosome duplication (GO:0051298)	2.83341692
72	bile acid metabolic process (GO:0008206)	2.82652739
73	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.80886066
74	tyrosine phosphorylation of STAT protein (GO:0007260)	2.79958702
75	negative regulation of neurotransmitter transport (GO:0051589)	2.78887205
76	ubiquinone biosynthetic process (GO:0006744)	2.77547289
77	serotonin metabolic process (GO:0042428)	2.75833785
78	inner ear receptor stereocilium organization (GO:0060122)	2.70368621
79	cyclic nucleotide catabolic process (GO:0009214)	2.69969124
80	regulation of action potential (GO:0098900)	2.69454561
81	exogenous drug catabolic process (GO:0042738)	2.64736394
82	cilium movement (GO:0003341)	2.63989587
83	ubiquinone metabolic process (GO:0006743)	2.63048050
84	phagocytosis, recognition (GO:0006910)	2.62890029
85	peristalsis (GO:0030432)	2.59710905
86	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	2.58959364
87	protein localization to cilium (GO:0061512)	2.57997736
88	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.56364761
89	drug catabolic process (GO:0042737)	2.54034401
90	regulation of interleukin-5 production (GO:0032674)	2.52453466
91	gamma-aminobutyric acid transport (GO:0015812)	2.51104886
92	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.51018150
93	histone H3-K9 methylation (GO:0051567)	2.49771238
94	regulation of heat generation (GO:0031650)	2.47722239
95	epithelial cilium movement (GO:0003351)	2.47082293
96	positive regulation of triglyceride metabolic process (GO:0090208)	2.45284405
97	startle response (GO:0001964)	2.45233796
98	drug transmembrane transport (GO:0006855)	2.44519923
99	multicellular organism reproduction (GO:0032504)	2.43661971
100	behavioral response to ethanol (GO:0048149)	2.43641673

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.18044028
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.06479415
3	IRF1_19129219_ChIP-ChIP_H3396_Human	3.57053007
4	VDR_22108803_ChIP-Seq_LS180_Human	3.50962705
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.21405939
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.66540898
7	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.55869597
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.50841113
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.48600631
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.44045391
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.27728257
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.07987042
13	FUS_26573619_Chip-Seq_HEK293_Human	2.07221599
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.06183488
15	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.95825395
16	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.89527594
17	EWS_26573619_Chip-Seq_HEK293_Human	1.87295979
18	BCAT_22108803_ChIP-Seq_LS180_Human	1.82311266
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.75756624
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.74605185
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.71709744
22	CBP_20019798_ChIP-Seq_JUKART_Human	1.71288505
23	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.71288505
24	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.71232327
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.70004830
26	P300_19829295_ChIP-Seq_ESCs_Human	1.67493389
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.66368741
28	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.65509030
29	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.62639561
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.60640189
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.59613561
32	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.58040600
33	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.58028614
34	STAT3_23295773_ChIP-Seq_U87_Human	1.52469075
35	TCF4_22108803_ChIP-Seq_LS180_Human	1.51366513
36	AR_21572438_ChIP-Seq_LNCaP_Human	1.50278552
37	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.47262466
38	SMAD4_21799915_ChIP-Seq_A2780_Human	1.45099206
39	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.44813254
40	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.42145037
41	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.42145037
42	TP53_22573176_ChIP-Seq_HFKS_Human	1.40499037
43	TCF4_23295773_ChIP-Seq_U87_Human	1.38523857
44	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.35655286
45	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35517074
46	RUNX2_22187159_ChIP-Seq_PCA_Human	1.35479607
47	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.34988832
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34487549
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34487549
50	AR_25329375_ChIP-Seq_VCAP_Human	1.34134274
51	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.32727140
52	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.32216704
53	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.31952344
54	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.31687629
55	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.30040877
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.28667861
57	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.28149796
58	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.26024296
59	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.25306693
60	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.24889574
61	ELK1_19687146_ChIP-ChIP_HELA_Human	1.24291994
62	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.23657668
63	RNF2_27304074_Chip-Seq_NSC_Mouse	1.23499252
64	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.23498279
65	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.22880429
66	KDM2B_26808549_Chip-Seq_REH_Human	1.22573695
67	CDX2_22108803_ChIP-Seq_LS180_Human	1.21983886
68	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19113868
69	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.19113868
70	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.18745571
71	NCOR_22424771_ChIP-Seq_293T_Human	1.17045786
72	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.14906407
73	TAF2_19829295_ChIP-Seq_ESCs_Human	1.14679934
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14417852
75	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13601578
76	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13017876
77	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.08001895
78	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.07689347
79	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.06408816
80	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.05227197
81	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.05179914
82	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.04592081
83	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.03741993
84	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02466930
85	AR_20517297_ChIP-Seq_VCAP_Human	1.00531412
86	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00207204
87	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.99469130
88	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.99038916
89	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.98974751
90	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.97974518
91	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.97824164
92	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.97524397
93	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.96182415
94	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.95826481
95	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95774916
96	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95173930
97	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.94792417
98	CJUN_26792858_Chip-Seq_BT549_Human	0.94293477
99	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.93697949
100	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.93008522

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	5.63650321
2	MP0002138_abnormal_hepatobiliary_system	5.60570535
3	MP0004147_increased_porphyrin_level	3.39695740
4	MP0003252_abnormal_bile_duct	3.17334404
5	MP0003011_delayed_dark_adaptation	2.83114459
6	MP0005645_abnormal_hypothalamus_physiol	2.66599872
7	MP0008875_abnormal_xenobiotic_pharmacok	2.63087292
8	MP0005379_endocrine/exocrine_gland_phen	2.39576232
9	MP0003880_abnormal_central_pattern	2.37123637
10	MP0002139_abnormal_hepatobiliary_system	2.36718528
11	MP0003787_abnormal_imprinting	2.35692371
12	MP0005647_abnormal_sex_gland	2.19951204
13	MP0003646_muscle_fatigue	2.19779847
14	MP0005551_abnormal_eye_electrophysiolog	2.17758346
15	MP0002102_abnormal_ear_morphology	2.16902693
16	MP0002653_abnormal_ependyma_morphology	2.11443214
17	MP0004381_abnormal_hair_follicle	2.08813184
18	MP0005084_abnormal_gallbladder_morpholo	2.04820997
19	MP0001986_abnormal_taste_sensitivity	2.00753776
20	MP0004885_abnormal_endolymph	1.98017598
21	MP0009697_abnormal_copulation	1.97833454
22	MP0002163_abnormal_gland_morphology	1.96675713
23	MP0005075_abnormal_melanosome_morpholog	1.92942001
24	MP0001968_abnormal_touch/_nociception	1.84879232
25	MP0004043_abnormal_pH_regulation	1.80719389
26	MP0005167_abnormal_blood-brain_barrier	1.78208717
27	MP0004133_heterotaxia	1.74473854
28	MP0009745_abnormal_behavioral_response	1.71700527
29	MP0001486_abnormal_startle_reflex	1.70651406
30	MP0000427_abnormal_hair_cycle	1.66209946
31	MP0001188_hyperpigmentation	1.61822707
32	MP0008877_abnormal_DNA_methylation	1.55640935
33	MP0002837_dystrophic_cardiac_calcinosis	1.51571930
34	MP0009840_abnormal_foam_cell	1.45479458
35	MP0002234_abnormal_pharynx_morphology	1.44872280
36	MP0000013_abnormal_adipose_tissue	1.38684475
37	MP0002638_abnormal_pupillary_reflex	1.36726720
38	MP0001501_abnormal_sleep_pattern	1.33646855
39	MP0003136_yellow_coat_color	1.29583547
40	MP0005253_abnormal_eye_physiology	1.28819753
41	MP0003119_abnormal_digestive_system	1.25763254
42	MP0003724_increased_susceptibility_to	1.25480258
43	MP0004142_abnormal_muscle_tone	1.22313508
44	MP0005310_abnormal_salivary_gland	1.11983505
45	MP0002736_abnormal_nociception_after	1.09023265
46	MP0001485_abnormal_pinna_reflex	1.07952456
47	MP0005174_abnormal_tail_pigmentation	1.07347857
48	MP0005085_abnormal_gallbladder_physiolo	1.05664833
49	MP0001764_abnormal_homeostasis	1.05395368
50	MP0009046_muscle_twitch	1.03026776
51	MP0002272_abnormal_nervous_system	1.01822749
52	MP0000049_abnormal_middle_ear	1.01681681
53	MP0004742_abnormal_vestibular_system	1.01390929
54	MP0002928_abnormal_bile_duct	1.01360394
55	MP0002064_seizures	0.95335945
56	MP0000647_abnormal_sebaceous_gland	0.94547108
57	MP0005646_abnormal_pituitary_gland	0.94531362
58	MP0001970_abnormal_pain_threshold	0.94219079
59	MP0004924_abnormal_behavior	0.93621582
60	MP0005386_behavior/neurological_phenoty	0.93621582
61	MP0002229_neurodegeneration	0.92355145
62	MP0000372_irregular_coat_pigmentation	0.91796663
63	MP0002572_abnormal_emotion/affect_behav	0.88691121
64	MP0008995_early_reproductive_senescence	0.87471328
65	MP0005360_urolithiasis	0.86134664
66	MP0000026_abnormal_inner_ear	0.82805872
67	MP0008872_abnormal_physiological_respon	0.82443591
68	MP0004130_abnormal_muscle_cell	0.78462793
69	MP0002876_abnormal_thyroid_physiology	0.77528739
70	MP0006276_abnormal_autonomic_nervous	0.77383735
71	MP0010329_abnormal_lipoprotein_level	0.76590455
72	MP0000778_abnormal_nervous_system	0.76523774
73	MP0005410_abnormal_fertilization	0.75998158
74	MP0003890_abnormal_embryonic-extraembry	0.75655548
75	MP0002733_abnormal_thermal_nociception	0.75093091
76	MP0002909_abnormal_adrenal_gland	0.73981187
77	MP0001963_abnormal_hearing_physiology	0.73618684
78	MP0006292_abnormal_olfactory_placode	0.73121569
79	MP0005195_abnormal_posterior_eye	0.72898145
80	MP0005365_abnormal_bile_salt	0.72258038
81	MP0003698_abnormal_male_reproductive	0.71836104
82	MP0002557_abnormal_social/conspecific_i	0.71510991
83	MP0002734_abnormal_mechanical_nocicepti	0.68895056
84	MP0000631_abnormal_neuroendocrine_gland	0.68360354
85	MP0001529_abnormal_vocalization	0.67975499
86	MP0005220_abnormal_exocrine_pancreas	0.66864535
87	MP0005503_abnormal_tendon_morphology	0.66015116
88	MP0000470_abnormal_stomach_morphology	0.66008304
89	MP0003635_abnormal_synaptic_transmissio	0.65858251
90	MP0004215_abnormal_myocardial_fiber	0.65731949
91	MP0001119_abnormal_female_reproductive	0.62597901
92	MP0003283_abnormal_digestive_organ	0.62363786
93	MP0002752_abnormal_somatic_nervous	0.61897464
94	MP0002210_abnormal_sex_determination	0.61349332
95	MP0000653_abnormal_sex_gland	0.60875282
96	MP0002067_abnormal_sensory_capabilities	0.59876872
97	MP0001664_abnormal_digestion	0.57720776
98	MP0003718_maternal_effect	0.57067118
99	MP0000685_abnormal_immune_system	0.55074886
100	MP0006082_CNS_inflammation	0.54660356

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Genetic anticipation (HP:0003743)	5.18035540
2	Decreased central vision (HP:0007663)	4.77792495
3	Cerebellar dysplasia (HP:0007033)	4.43848373
4	Concave nail (HP:0001598)	4.17700137
5	Chronic hepatic failure (HP:0100626)	4.01587638
6	Attenuation of retinal blood vessels (HP:0007843)	3.84154548
7	Inability to walk (HP:0002540)	3.78111357
8	Pancreatic cysts (HP:0001737)	3.68620246
9	Action tremor (HP:0002345)	3.59328715
10	Progressive cerebellar ataxia (HP:0002073)	3.45855612
11	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.43905554
12	Gaze-evoked nystagmus (HP:0000640)	3.38636300
13	Pancreatic fibrosis (HP:0100732)	3.36275061
14	Increased corneal curvature (HP:0100692)	3.26510069
15	Keratoconus (HP:0000563)	3.26510069
16	Pendular nystagmus (HP:0012043)	3.25198007
17	Abnormality of macular pigmentation (HP:0008002)	3.19934241
18	Partial agenesis of the corpus callosum (HP:0001338)	3.06154591
19	Absence seizures (HP:0002121)	3.05439202
20	Type II lissencephaly (HP:0007260)	3.04372614
21	3-Methylglutaconic aciduria (HP:0003535)	3.01634621
22	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.99494606
23	Abnormality of alanine metabolism (HP:0010916)	2.99494606
24	Hyperalaninemia (HP:0003348)	2.99494606
25	Mutism (HP:0002300)	2.99439551
26	Congenital stationary night blindness (HP:0007642)	2.98460645
27	True hermaphroditism (HP:0010459)	2.97867423
28	Abnormality of the hepatic vasculature (HP:0006707)	2.96080743
29	Hypophosphatemic rickets (HP:0004912)	2.95488465
30	Molar tooth sign on MRI (HP:0002419)	2.89161729
31	Abnormality of midbrain morphology (HP:0002418)	2.89161729
32	Tubular atrophy (HP:0000092)	2.84110908
33	Intrahepatic cholestasis (HP:0001406)	2.82264924
34	Dysmetric saccades (HP:0000641)	2.75010480
35	Absent speech (HP:0001344)	2.73163933
36	Abnormality of homocysteine metabolism (HP:0010919)	2.72406711
37	Homocystinuria (HP:0002156)	2.72406711
38	Congenital sensorineural hearing impairment (HP:0008527)	2.70152370
39	Impaired proprioception (HP:0010831)	2.64271430
40	Renal cortical cysts (HP:0000803)	2.63598088
41	Macroglossia (HP:0000158)	2.58209220
42	Alveolar cell carcinoma (HP:0006519)	2.55834310
43	Elevated erythrocyte sedimentation rate (HP:0003565)	2.54649324
44	Prostate neoplasm (HP:0100787)	2.53740294
45	Abnormality of the renal cortex (HP:0011035)	2.47573470
46	Abnormal rod and cone electroretinograms (HP:0008323)	2.47031504
47	Nephronophthisis (HP:0000090)	2.41807382
48	Atonic seizures (HP:0010819)	2.41636786
49	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.40104457
50	Methylmalonic acidemia (HP:0002912)	2.39544804
51	Dialeptic seizures (HP:0011146)	2.35785346
52	Neoplasm of the tracheobronchial system (HP:0100552)	2.35138115
53	Bony spicule pigmentary retinopathy (HP:0007737)	2.33526176
54	Occipital encephalocele (HP:0002085)	2.31783731
55	Severe muscular hypotonia (HP:0006829)	2.29222054
56	Hyperventilation (HP:0002883)	2.28952675
57	Tubulointerstitial nephritis (HP:0001970)	2.27946986
58	Furrowed tongue (HP:0000221)	2.27600698
59	Megalencephaly (HP:0001355)	2.24517148
60	Febrile seizures (HP:0002373)	2.20817855
61	Abnormality of the renal medulla (HP:0100957)	2.19895729
62	Progressive macrocephaly (HP:0004481)	2.18509486
63	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.10287237
64	Absent/shortened dynein arms (HP:0200106)	2.10287237
65	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.08401249
66	Abnormality of vitamin B metabolism (HP:0004340)	2.04273138
67	Arthropathy (HP:0003040)	2.03165134
68	Abnormal pancreas size (HP:0012094)	2.01011484
69	Stomach cancer (HP:0012126)	1.98819898
70	Congenital hepatic fibrosis (HP:0002612)	1.97202275
71	Focal seizures (HP:0007359)	1.96314773
72	Unilateral renal agenesis (HP:0000122)	1.95387353
73	Hypoplastic iliac wings (HP:0002866)	1.95200177
74	Optic disc pallor (HP:0000543)	1.94582666
75	Abolished electroretinogram (ERG) (HP:0000550)	1.93878185
76	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.93566945
77	Hypoplasia of the fovea (HP:0007750)	1.93566945
78	Confusion (HP:0001289)	1.93333467
79	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.91240328
80	Retinal atrophy (HP:0001105)	1.89223096
81	Abnormality of the fovea (HP:0000493)	1.89043329
82	Hyperlipoproteinemia (HP:0010980)	1.87806340
83	Broad-based gait (HP:0002136)	1.87592866
84	Acute necrotizing encephalopathy (HP:0006965)	1.87426230
85	Methylmalonic aciduria (HP:0012120)	1.86686313
86	Urinary bladder sphincter dysfunction (HP:0002839)	1.85960696
87	Short tibia (HP:0005736)	1.85224544
88	Clumsiness (HP:0002312)	1.83040956
89	Retinitis pigmentosa (HP:0000510)	1.82886205
90	Protruding tongue (HP:0010808)	1.81787736
91	Fair hair (HP:0002286)	1.81414358
92	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.80679531
93	Polymicrogyria (HP:0002126)	1.80446092
94	Progressive inability to walk (HP:0002505)	1.80329430
95	Cystic liver disease (HP:0006706)	1.79638452
96	Portal hypertension (HP:0001409)	1.77490800
97	Impaired vibratory sensation (HP:0002495)	1.75875570
98	Tinnitus (HP:0000360)	1.75586671
99	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.74244407
100	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.73965689

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.41452721
2	ADRBK2	4.58232093
3	PIK3CG	4.18009821
4	CDK19	3.52724729
5	MAP3K4	3.03843261
6	MAP2K7	2.97246703
7	IRAK1	2.49619431
8	DAPK2	2.47958514
9	OXSR1	2.47865349
10	ACVR1B	2.31703315
11	BCR	2.20814512
12	MAP3K6	2.19517598
13	EPHA4	2.05434287
14	GRK1	1.99221394
15	WNK4	1.96966140
16	PINK1	1.90235864
17	BMPR1B	1.89653404
18	NUAK1	1.68123925
19	CSNK1G2	1.58609248
20	ZAK	1.55921584
21	BRD4	1.48917195
22	FER	1.37626203
23	CSNK1G1	1.34353505
24	PBK	1.32791534
25	MAP2K4	1.31150371
26	TXK	1.30565951
27	MAP3K7	1.26469638
28	MATK	1.26222551
29	MAP3K5	1.24544843
30	TIE1	1.24010494
31	SIK2	1.18595145
32	SIK3	1.15437064
33	CSNK1G3	1.15350448
34	CASK	1.11694602
35	DYRK3	1.11673030
36	TLK1	1.05365472
37	PIK3CA	0.98917622
38	MAP4K2	0.98085204
39	CAMK1G	0.95914977
40	STK11	0.94461836
41	ERBB3	0.94188394
42	MAP3K14	0.92536726
43	TAOK3	0.83793667
44	IRAK2	0.82643099
45	CAMK1	0.82038054
46	ADRBK1	0.81695465
47	DYRK2	0.76008917
48	CHUK	0.75186821
49	PNCK	0.74980582
50	MAPK13	0.73541721
51	KIT	0.70270470
52	CSNK1A1L	0.68133106
53	NLK	0.67218640
54	IRAK4	0.66922965
55	TGFBR1	0.63821360
56	MARK3	0.63438942
57	PKN1	0.59396858
58	WNK3	0.56211475
59	PRKCQ	0.56161518
60	RPS6KA4	0.54310619
61	RPS6KA5	0.53267311
62	CAMK1D	0.52563801
63	PRKCE	0.51282346
64	TRPM7	0.49010786
65	RPS6KA6	0.46102244
66	MUSK	0.45988125
67	ERBB2	0.45900520
68	CAMKK1	0.43985364
69	LATS1	0.43148829
70	CAMKK2	0.43012717
71	EPHA3	0.42283137
72	PRKG1	0.39588066
73	PRKAA1	0.39011033
74	CAMK4	0.38260478
75	PRKCH	0.36716131
76	BCKDK	0.35469269
77	PTK6	0.35059014
78	CSNK1D	0.34478319
79	IKBKE	0.34180802
80	MAP2K6	0.33909544
81	PRKACA	0.33813905
82	CDK9	0.33774628
83	DYRK1A	0.32672954
84	SGK2	0.32512675
85	INSRR	0.31076821
86	VRK1	0.28895567
87	IKBKB	0.28606784
88	PRKACB	0.27661317
89	PRKAA2	0.26862237
90	PTK2B	0.23158807
91	MAP3K9	0.23000741
92	KDR	0.22245621
93	MAP3K11	0.21862612
94	CAMK2A	0.20981218
95	STK3	0.20925498
96	MELK	0.20044236
97	BMX	0.19216884
98	TAF1	0.18399092
99	PRKCG	0.18281851
100	MAPK1	0.17733937

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	5.75432710
2	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	3.78037504
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.60944713
4	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.42270636
5	Butanoate metabolism_Homo sapiens_hsa00650	3.06914403
6	Protein export_Homo sapiens_hsa03060	2.53843376
7	Phototransduction_Homo sapiens_hsa04744	2.32496034
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.26349513
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.25391294
10	Olfactory transduction_Homo sapiens_hsa04740	2.14510981
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.88291302
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.77323029
13	Caffeine metabolism_Homo sapiens_hsa00232	1.76055862
14	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.73253724
15	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.67182323
16	Taste transduction_Homo sapiens_hsa04742	1.67118213
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.65521993
18	Basal transcription factors_Homo sapiens_hsa03022	1.59048121
19	Sulfur metabolism_Homo sapiens_hsa00920	1.58965586
20	Circadian rhythm_Homo sapiens_hsa04710	1.58010171
21	ABC transporters_Homo sapiens_hsa02010	1.52031325
22	Morphine addiction_Homo sapiens_hsa05032	1.44313626
23	Alcoholism_Homo sapiens_hsa05034	1.41147883
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.36924642
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.34961960
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.33640403
27	Retinol metabolism_Homo sapiens_hsa00830	1.30204102
28	Selenocompound metabolism_Homo sapiens_hsa00450	1.18402585
29	Nicotine addiction_Homo sapiens_hsa05033	1.16786135
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.14109661
31	Propanoate metabolism_Homo sapiens_hsa00640	1.09044857
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.09019086
33	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.08784435
34	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.03479297
35	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.02840964
36	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.02035989
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.01279057
38	Tryptophan metabolism_Homo sapiens_hsa00380	0.99419296
39	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.98636248
40	Chemical carcinogenesis_Homo sapiens_hsa05204	0.88966944
41	RNA polymerase_Homo sapiens_hsa03020	0.84536902
42	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.83794830
43	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.83549538
44	Serotonergic synapse_Homo sapiens_hsa04726	0.83238870
45	Circadian entrainment_Homo sapiens_hsa04713	0.80590262
46	Salivary secretion_Homo sapiens_hsa04970	0.80417824
47	Oxidative phosphorylation_Homo sapiens_hsa00190	0.73853716
48	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.72871952
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.70947830
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66560925
51	GABAergic synapse_Homo sapiens_hsa04727	0.64129272
52	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.62895677
53	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.62302083
54	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.61071740
55	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.60395343
56	Cholinergic synapse_Homo sapiens_hsa04725	0.59364102
57	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.58053932
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.56984390
59	Long-term depression_Homo sapiens_hsa04730	0.54847226
60	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.54664966
61	Dopaminergic synapse_Homo sapiens_hsa04728	0.53124467
62	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.53091436
63	Insulin secretion_Homo sapiens_hsa04911	0.52722743
64	Homologous recombination_Homo sapiens_hsa03440	0.51100038
65	Sphingolipid metabolism_Homo sapiens_hsa00600	0.50941298
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50879682
67	Primary immunodeficiency_Homo sapiens_hsa05340	0.48291778
68	Peroxisome_Homo sapiens_hsa04146	0.48242504
69	PPAR signaling pathway_Homo sapiens_hsa03320	0.48240735
70	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.47684906
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.46429301
72	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.43029016
73	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.42960279
74	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.41685176
75	Bile secretion_Homo sapiens_hsa04976	0.41416647
76	Insulin resistance_Homo sapiens_hsa04931	0.40764858
77	Type II diabetes mellitus_Homo sapiens_hsa04930	0.37392647
78	Viral carcinogenesis_Homo sapiens_hsa05203	0.36539472
79	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.35101297
80	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.35015241
81	Graft-versus-host disease_Homo sapiens_hsa05332	0.34987592
82	Mineral absorption_Homo sapiens_hsa04978	0.33448796
83	Huntingtons disease_Homo sapiens_hsa05016	0.33349996
84	Calcium signaling pathway_Homo sapiens_hsa04020	0.33196775
85	Herpes simplex infection_Homo sapiens_hsa05168	0.31126561
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.30843752
87	Ras signaling pathway_Homo sapiens_hsa04014	0.30726116
88	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.30211468
89	Parkinsons disease_Homo sapiens_hsa05012	0.29615778
90	Purine metabolism_Homo sapiens_hsa00230	0.29032463
91	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.27714445
92	Metabolic pathways_Homo sapiens_hsa01100	0.26777667
93	Glutamatergic synapse_Homo sapiens_hsa04724	0.26431335
94	Melanoma_Homo sapiens_hsa05218	0.26114993
95	Cocaine addiction_Homo sapiens_hsa05030	0.25356991
96	MAPK signaling pathway_Homo sapiens_hsa04010	0.25109970
97	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.24830622
98	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.24545042
99	Prolactin signaling pathway_Homo sapiens_hsa04917	0.21837624
100	FoxO signaling pathway_Homo sapiens_hsa04068	0.21792704

OR10AE1P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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