ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	retinal cone cell development (GO:0046549)	4.33522832
2	response to pheromone (GO:0019236)	4.29317854
3	L-fucose catabolic process (GO:0042355)	3.93133010
4	fucose catabolic process (GO:0019317)	3.93133010
5	L-fucose metabolic process (GO:0042354)	3.93133010
6	mannosylation (GO:0097502)	3.90712189
7	axoneme assembly (GO:0035082)	3.87292911
8	DNA double-strand break processing (GO:0000729)	3.83825446
9	photoreceptor cell maintenance (GO:0045494)	3.72074866
10	regulation of cilium movement (GO:0003352)	3.68798590
11	gamma-aminobutyric acid transport (GO:0015812)	3.58570211
12	protein-cofactor linkage (GO:0018065)	3.58049210
13	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.56681326
14	DNA deamination (GO:0045006)	3.56368839
15	water-soluble vitamin biosynthetic process (GO:0042364)	3.54911857
16	detection of light stimulus involved in visual perception (GO:0050908)	3.53045058
17	detection of light stimulus involved in sensory perception (GO:0050962)	3.53045058
18	glycosphingolipid biosynthetic process (GO:0006688)	3.49500021
19	preassembly of GPI anchor in ER membrane (GO:0016254)	3.46566548
20	tachykinin receptor signaling pathway (GO:0007217)	3.40763488
21	behavioral response to nicotine (GO:0035095)	3.37870553
22	piRNA metabolic process (GO:0034587)	3.26268402
23	protein localization to cilium (GO:0061512)	3.24489618
24	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.18706236
25	platelet dense granule organization (GO:0060155)	3.17119909
26	protein polyglutamylation (GO:0018095)	3.16721366
27	respiratory chain complex IV assembly (GO:0008535)	3.16610199
28	cilium morphogenesis (GO:0060271)	3.16325014
29	transepithelial transport (GO:0070633)	3.14813014
30	nonmotile primary cilium assembly (GO:0035058)	3.11846876
31	cornea development in camera-type eye (GO:0061303)	3.10958294
32	photoreceptor cell development (GO:0042461)	3.09300523
33	branched-chain amino acid catabolic process (GO:0009083)	3.06466102
34	GPI anchor metabolic process (GO:0006505)	3.04910500
35	cullin deneddylation (GO:0010388)	3.03444731
36	histone H2A acetylation (GO:0043968)	3.03159129
37	indolalkylamine metabolic process (GO:0006586)	3.02456054
38	cell wall macromolecule metabolic process (GO:0044036)	2.98534325
39	inositol phosphate catabolic process (GO:0071545)	2.92588230
40	multicellular organism reproduction (GO:0032504)	2.91330987
41	DNA integration (GO:0015074)	2.90739722
42	presynaptic membrane assembly (GO:0097105)	2.90239285
43	somite development (GO:0061053)	2.89589727
44	L-methionine biosynthetic process (GO:0071265)	2.88899533
45	amino acid salvage (GO:0043102)	2.88899533
46	L-methionine salvage (GO:0071267)	2.88899533
47	base-excision repair, AP site formation (GO:0006285)	2.88445723
48	adenosine metabolic process (GO:0046085)	2.88117219
49	amine catabolic process (GO:0009310)	2.86965408
50	cellular biogenic amine catabolic process (GO:0042402)	2.86965408
51	cellular ketone body metabolic process (GO:0046950)	2.86636317
52	establishment of protein localization to Golgi (GO:0072600)	2.83174144
53	cytochrome complex assembly (GO:0017004)	2.82938074
54	ubiquinone biosynthetic process (GO:0006744)	2.82302010
55	eye photoreceptor cell development (GO:0042462)	2.79962776
56	protein deneddylation (GO:0000338)	2.79598021
57	polyol catabolic process (GO:0046174)	2.78962614
58	protein targeting to Golgi (GO:0000042)	2.78850548
59	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.77802241
60	behavioral response to ethanol (GO:0048149)	2.76601372
61	glycolipid biosynthetic process (GO:0009247)	2.76306767
62	C-terminal protein lipidation (GO:0006501)	2.75929228
63	pyrimidine nucleobase catabolic process (GO:0006208)	2.74391308
64	regulation of action potential (GO:0098900)	2.73667963
65	regulation of protein glycosylation (GO:0060049)	2.73266844
66	peptidyl-histidine modification (GO:0018202)	2.72795825
67	intraciliary transport (GO:0042073)	2.70674794
68	C-terminal protein amino acid modification (GO:0018410)	2.70143909
69	inositol phosphate dephosphorylation (GO:0046855)	2.70084401
70	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.70084401
71	regulation of triglyceride catabolic process (GO:0010896)	2.69594659
72	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.68357074
73	tryptophan catabolic process (GO:0006569)	2.66137154
74	indole-containing compound catabolic process (GO:0042436)	2.66137154
75	indolalkylamine catabolic process (GO:0046218)	2.66137154
76	regulation of meiosis I (GO:0060631)	2.65209259
77	protein complex biogenesis (GO:0070271)	2.62743933
78	negative regulation of telomere maintenance (GO:0032205)	2.60486400
79	ubiquinone metabolic process (GO:0006743)	2.59891295
80	ketone body metabolic process (GO:1902224)	2.58213664
81	anterograde synaptic vesicle transport (GO:0048490)	2.57912907
82	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.57891377
83	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.57274820
84	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.56143088
85	neural tube formation (GO:0001841)	2.56052689
86	branched-chain amino acid metabolic process (GO:0009081)	2.55647811
87	inner ear receptor stereocilium organization (GO:0060122)	2.52509529
88	protein localization to Golgi apparatus (GO:0034067)	2.51681509
89	regulation of development, heterochronic (GO:0040034)	2.49980482
90	recombinational repair (GO:0000725)	2.49851323
91	double-strand break repair via homologous recombination (GO:0000724)	2.48825189
92	regulation of timing of cell differentiation (GO:0048505)	2.48026718
93	rhodopsin mediated signaling pathway (GO:0016056)	2.47868780
94	sulfation (GO:0051923)	2.47239009
95	negative regulation of mast cell activation (GO:0033004)	2.47016003
96	tryptophan metabolic process (GO:0006568)	2.46593255
97	iron-sulfur cluster assembly (GO:0016226)	2.45794217
98	metallo-sulfur cluster assembly (GO:0031163)	2.45794217
99	regulation of microtubule-based movement (GO:0060632)	2.45122065
100	arginine metabolic process (GO:0006525)	2.44961224

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.95699810
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.07581069
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.82492322
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.76629952
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.70752366
6	VDR_22108803_ChIP-Seq_LS180_Human	2.47255076
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.44578563
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.43088975
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.35360151
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.32069929
11	EWS_26573619_Chip-Seq_HEK293_Human	2.30298741
12	FUS_26573619_Chip-Seq_HEK293_Human	2.25171981
13	P300_19829295_ChIP-Seq_ESCs_Human	2.23441212
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.20123254
15	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.12798496
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.10184536
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.09654610
18	TAF15_26573619_Chip-Seq_HEK293_Human	2.03610073
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.03499554
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.91795044
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.90540116
22	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.87223285
23	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.83234998
24	CBP_20019798_ChIP-Seq_JUKART_Human	1.80524408
25	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.80524408
26	ELK1_19687146_ChIP-ChIP_HELA_Human	1.75010138
27	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.68091908
28	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.67265616
29	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.60165434
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.59509283
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.59303141
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.56502569
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.55005989
34	IRF1_19129219_ChIP-ChIP_H3396_Human	1.53730640
35	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.53678190
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53089204
37	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.52226965
38	SMAD4_21799915_ChIP-Seq_A2780_Human	1.51546224
39	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.50608443
40	SOX2_19829295_ChIP-Seq_ESCs_Human	1.47778793
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.47778793
42	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.47454826
43	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.45143170
44	BCAT_22108803_ChIP-Seq_LS180_Human	1.43819082
45	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.42520785
46	VDR_23849224_ChIP-Seq_CD4+_Human	1.42123910
47	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.41558619
48	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.39024621
49	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.37359144
50	STAT3_23295773_ChIP-Seq_U87_Human	1.37194150
51	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.36469270
52	AR_25329375_ChIP-Seq_VCAP_Human	1.36314277
53	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.34291124
54	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.34091433
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.33782172
56	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.33782172
57	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.33217028
58	TCF4_22108803_ChIP-Seq_LS180_Human	1.32884533
59	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.31585493
60	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.31471228
61	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.30866082
62	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.29510877
63	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.29086887
64	AR_20517297_ChIP-Seq_VCAP_Human	1.28747682
65	CDX2_22108803_ChIP-Seq_LS180_Human	1.28027938
66	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.27667366
67	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.25511913
68	TCF4_23295773_ChIP-Seq_U87_Human	1.25354811
69	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.25274940
70	MYC_18940864_ChIP-ChIP_HL60_Human	1.24259907
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.22496784
72	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.22082329
73	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20963951
74	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.20930386
75	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20930386
76	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.20039347
77	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.19938112
78	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.19290992
79	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.15930015
80	AR_21572438_ChIP-Seq_LNCaP_Human	1.15009077
81	P53_22387025_ChIP-Seq_ESCs_Mouse	1.14638935
82	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.13474823
83	HOXB7_26014856_ChIP-Seq_BT474_Human	1.12051063
84	EZH2_22144423_ChIP-Seq_EOC_Human	1.11705471
85	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.11271403
86	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.11203760
87	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.10848352
88	NCOR_22424771_ChIP-Seq_293T_Human	1.10725070
89	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.10721827
90	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.07919644
91	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.06951431
92	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.05750137
93	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.02207074
94	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.01173112
95	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.99930533
96	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.98834100
97	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97733300
98	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.97183125
99	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.97088763
100	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.96587920

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.75597253
2	MP0003011_delayed_dark_adaptation	3.13530549
3	MP0000569_abnormal_digit_pigmentation	2.79574481
4	MP0002102_abnormal_ear_morphology	2.70036084
5	MP0005551_abnormal_eye_electrophysiolog	2.65710077
6	MP0003880_abnormal_central_pattern	2.64718837
7	MP0006072_abnormal_retinal_apoptosis	2.59668974
8	MP0005084_abnormal_gallbladder_morpholo	2.56638213
9	MP0005646_abnormal_pituitary_gland	2.27755530
10	MP0005253_abnormal_eye_physiology	2.25809491
11	MP0001984_abnormal_olfaction	2.13833142
12	MP0002736_abnormal_nociception_after	2.13702150
13	MP0001968_abnormal_touch/_nociception	2.05072646
14	MP0004147_increased_porphyrin_level	2.00990976
15	MP0003787_abnormal_imprinting	2.00881731
16	MP0002653_abnormal_ependyma_morphology	1.95941182
17	MP0005645_abnormal_hypothalamus_physiol	1.95268828
18	MP0003195_calcinosis	1.91734327
19	MP0000427_abnormal_hair_cycle	1.84826069
20	MP0010386_abnormal_urinary_bladder	1.84424404
21	MP0002837_dystrophic_cardiac_calcinosis	1.74688574
22	MP0006276_abnormal_autonomic_nervous	1.72446782
23	MP0008789_abnormal_olfactory_epithelium	1.69567778
24	MP0008875_abnormal_xenobiotic_pharmacok	1.69178432
25	MP0008058_abnormal_DNA_repair	1.67345027
26	MP0003136_yellow_coat_color	1.66337962
27	MP0005085_abnormal_gallbladder_physiolo	1.64014364
28	MP0000372_irregular_coat_pigmentation	1.63379109
29	MP0008872_abnormal_physiological_respon	1.62674051
30	MP0000647_abnormal_sebaceous_gland	1.62460489
31	MP0002928_abnormal_bile_duct	1.58726054
32	MP0001501_abnormal_sleep_pattern	1.57161392
33	MP0002751_abnormal_autonomic_nervous	1.56526794
34	MP0000631_abnormal_neuroendocrine_gland	1.55790236
35	MP0006292_abnormal_olfactory_placode	1.54235277
36	MP0002138_abnormal_hepatobiliary_system	1.51636864
37	MP0009046_muscle_twitch	1.51218496
38	MP0002272_abnormal_nervous_system	1.48238790
39	MP0005187_abnormal_penis_morphology	1.47238399
40	MP0004142_abnormal_muscle_tone	1.41048453
41	MP0009745_abnormal_behavioral_response	1.36384806
42	MP0002638_abnormal_pupillary_reflex	1.34419953
43	MP0005174_abnormal_tail_pigmentation	1.32650220
44	MP0001764_abnormal_homeostasis	1.32299028
45	MP0001486_abnormal_startle_reflex	1.22796897
46	MP0005167_abnormal_blood-brain_barrier	1.21032413
47	MP0005365_abnormal_bile_salt	1.16455747
48	MP0002277_abnormal_respiratory_mucosa	1.13209332
49	MP0002095_abnormal_skin_pigmentation	1.11936699
50	MP0008775_abnormal_heart_ventricle	1.11907228
51	MP0001485_abnormal_pinna_reflex	1.10582115
52	MP0000015_abnormal_ear_pigmentation	1.10569737
53	MP0002234_abnormal_pharynx_morphology	1.10056901
54	MP0003646_muscle_fatigue	1.09883423
55	MP0004215_abnormal_myocardial_fiber	1.09710348
56	MP0000383_abnormal_hair_follicle	1.07881222
57	MP0005499_abnormal_olfactory_system	1.06393839
58	MP0005394_taste/olfaction_phenotype	1.06393839
59	MP0002876_abnormal_thyroid_physiology	1.05345537
60	MP0008057_abnormal_DNA_replication	1.04231321
61	MP0001529_abnormal_vocalization	1.04213982
62	MP0002572_abnormal_emotion/affect_behav	1.04071879
63	MP0005670_abnormal_white_adipose	1.02880154
64	MP0004484_altered_response_of	1.02445487
65	MP0004133_heterotaxia	1.01988465
66	MP0003252_abnormal_bile_duct	1.01967953
67	MP0005410_abnormal_fertilization	1.00901318
68	MP0005083_abnormal_biliary_tract	0.99454863
69	MP0002557_abnormal_social/conspecific_i	0.98931373
70	MP0005195_abnormal_posterior_eye	0.97840180
71	MP0003698_abnormal_male_reproductive	0.95110063
72	MP0001324_abnormal_eye_pigmentation	0.94096733
73	MP0004742_abnormal_vestibular_system	0.92872950
74	MP0002282_abnormal_trachea_morphology	0.92320304
75	MP0001970_abnormal_pain_threshold	0.90777550
76	MP0001929_abnormal_gametogenesis	0.89056031
77	MP0003878_abnormal_ear_physiology	0.88163944
78	MP0005377_hearing/vestibular/ear_phenot	0.88163944
79	MP0002064_seizures	0.88089767
80	MP0004885_abnormal_endolymph	0.87847486
81	MP0009780_abnormal_chondrocyte_physiolo	0.84670752
82	MP0003122_maternal_imprinting	0.83984823
83	MP0003950_abnormal_plasma_membrane	0.83583617
84	MP0000778_abnormal_nervous_system	0.82634475
85	MP0004043_abnormal_pH_regulation	0.82532358
86	MP0000516_abnormal_urinary_system	0.82472374
87	MP0005367_renal/urinary_system_phenotyp	0.82472374
88	MP0001502_abnormal_circadian_rhythm	0.81294133
89	MP0002752_abnormal_somatic_nervous	0.81121645
90	MP0006054_spinal_hemorrhage	0.80767519
91	MP0002734_abnormal_mechanical_nocicepti	0.80049910
92	MP0001270_distended_abdomen	0.79154981
93	MP0003137_abnormal_impulse_conducting	0.78491908
94	MP0005386_behavior/neurological_phenoty	0.78310410
95	MP0004924_abnormal_behavior	0.78310410
96	MP0000538_abnormal_urinary_bladder	0.77332815
97	MP0002090_abnormal_vision	0.77084945
98	MP0002229_neurodegeneration	0.76973638
99	MP0005391_vision/eye_phenotype	0.76943469
100	MP0002160_abnormal_reproductive_system	0.74767342

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	4.31345479
2	Pancreatic cysts (HP:0001737)	4.18077246
3	Medial flaring of the eyebrow (HP:0010747)	3.84311023
4	Abnormality of midbrain morphology (HP:0002418)	3.73468788
5	Molar tooth sign on MRI (HP:0002419)	3.73468788
6	True hermaphroditism (HP:0010459)	3.52308959
7	Pancreatic fibrosis (HP:0100732)	3.40623636
8	Nephronophthisis (HP:0000090)	3.31682098
9	Abnormality of the renal cortex (HP:0011035)	3.22777242
10	Congenital stationary night blindness (HP:0007642)	3.12267764
11	Abnormality of the renal medulla (HP:0100957)	3.12112175
12	Congenital primary aphakia (HP:0007707)	3.11380585
13	Gait imbalance (HP:0002141)	3.10782989
14	3-Methylglutaconic aciduria (HP:0003535)	2.89770173
15	Methylmalonic acidemia (HP:0002912)	2.85285321
16	Retinal dysplasia (HP:0007973)	2.84806999
17	Nephrogenic diabetes insipidus (HP:0009806)	2.81703440
18	Lissencephaly (HP:0001339)	2.71904010
19	Chronic hepatic failure (HP:0100626)	2.68493051
20	Methylmalonic aciduria (HP:0012120)	2.62666134
21	Cerebellar dysplasia (HP:0007033)	2.62496381
22	Attenuation of retinal blood vessels (HP:0007843)	2.61590302
23	Stomach cancer (HP:0012126)	2.57433698
24	Bile duct proliferation (HP:0001408)	2.50628336
25	Abnormal biliary tract physiology (HP:0012439)	2.50628336
26	Pendular nystagmus (HP:0012043)	2.41746300
27	Cystic liver disease (HP:0006706)	2.41404577
28	Renal cortical cysts (HP:0000803)	2.41292165
29	Abnormal drinking behavior (HP:0030082)	2.40225755
30	Polydipsia (HP:0001959)	2.40225755
31	Focal motor seizures (HP:0011153)	2.36579143
32	Keratoconus (HP:0000563)	2.35725500
33	Increased corneal curvature (HP:0100692)	2.35725500
34	Tubular atrophy (HP:0000092)	2.33702648
35	Genital tract atresia (HP:0001827)	2.32328928
36	Absent speech (HP:0001344)	2.31749413
37	Vaginal atresia (HP:0000148)	2.31544447
38	Optic nerve hypoplasia (HP:0000609)	2.30717961
39	Hyperglycinemia (HP:0002154)	2.30076396
40	Abnormal protein glycosylation (HP:0012346)	2.29335791
41	Abnormal glycosylation (HP:0012345)	2.29335791
42	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.29335791
43	Abnormal protein N-linked glycosylation (HP:0012347)	2.29335791
44	Hyperventilation (HP:0002883)	2.25055398
45	Inability to walk (HP:0002540)	2.23558554
46	Occipital encephalocele (HP:0002085)	2.23117896
47	Colon cancer (HP:0003003)	2.22407520
48	Thyroid-stimulating hormone excess (HP:0002925)	2.15427381
49	Polyuria (HP:0000103)	2.15240365
50	Abolished electroretinogram (ERG) (HP:0000550)	2.12452309
51	Type I transferrin isoform profile (HP:0003642)	2.11330752
52	Hypothermia (HP:0002045)	2.10269647
53	Intestinal atresia (HP:0011100)	2.09231259
54	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.08810005
55	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.05321616
56	Sclerocornea (HP:0000647)	2.05107863
57	Progressive macrocephaly (HP:0004481)	2.02683322
58	Increased CSF lactate (HP:0002490)	2.02497531
59	Severe muscular hypotonia (HP:0006829)	2.02092265
60	Progressive inability to walk (HP:0002505)	2.01813913
61	Poor coordination (HP:0002370)	1.99129110
62	Large for gestational age (HP:0001520)	1.97489553
63	Postaxial foot polydactyly (HP:0001830)	1.97043818
64	Postaxial hand polydactyly (HP:0001162)	1.96977326
65	Albinism (HP:0001022)	1.95068899
66	Thyroiditis (HP:0100646)	1.95035179
67	Acute necrotizing encephalopathy (HP:0006965)	1.92885154
68	Hypomagnesemia (HP:0002917)	1.91140367
69	Hypoplasia of the fovea (HP:0007750)	1.90041982
70	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.90041982
71	Congenital hepatic fibrosis (HP:0002612)	1.89478206
72	Abnormality of vitamin B metabolism (HP:0004340)	1.88162669
73	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.87548690
74	Neonatal respiratory distress (HP:0002643)	1.85471730
75	Ketosis (HP:0001946)	1.85443816
76	Pachygyria (HP:0001302)	1.84329989
77	Mitochondrial inheritance (HP:0001427)	1.81926436
78	Type 2 muscle fiber atrophy (HP:0003554)	1.81130602
79	Febrile seizures (HP:0002373)	1.80267795
80	Congenital sensorineural hearing impairment (HP:0008527)	1.80212913
81	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.80080684
82	Acute encephalopathy (HP:0006846)	1.79974159
83	Decreased testicular size (HP:0008734)	1.78867364
84	Dandy-Walker malformation (HP:0001305)	1.78357824
85	Progressive microcephaly (HP:0000253)	1.77714487
86	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.76034976
87	Abnormality of glycine metabolism (HP:0010895)	1.75619241
88	Abnormality of serine family amino acid metabolism (HP:0010894)	1.75619241
89	Stomatitis (HP:0010280)	1.75566945
90	Abnormality of macular pigmentation (HP:0008002)	1.74427975
91	Rib fusion (HP:0000902)	1.74304734
92	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.73976908
93	Furrowed tongue (HP:0000221)	1.73389673
94	Astigmatism (HP:0000483)	1.72475363
95	Anencephaly (HP:0002323)	1.72400797
96	Male pseudohermaphroditism (HP:0000037)	1.71646384
97	Retinitis pigmentosa (HP:0000510)	1.70647018
98	Hyperglycinuria (HP:0003108)	1.70575514
99	Short tibia (HP:0005736)	1.69379263
100	Calf muscle hypertrophy (HP:0008981)	1.69064369

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	5.28597267
2	FRK	4.35620390
3	NUAK1	3.00097770
4	ZAK	2.62759562
5	CDK19	2.43986173
6	TRIM28	2.41762167
7	MUSK	2.37513865
8	WNK3	2.23715185
9	CASK	2.07732563
10	ERBB3	1.95876221
11	ADRBK2	1.95388537
12	MAPK13	1.88024576
13	GRK1	1.85294894
14	BMPR1B	1.84288151
15	MST4	1.83429584
16	BCR	1.82196678
17	BCKDK	1.72613223
18	EPHA4	1.69262015
19	OXSR1	1.60985580
20	PAK3	1.58009607
21	TAOK3	1.55649441
22	MARK1	1.52808639
23	PINK1	1.49556332
24	VRK2	1.47429815
25	STK38L	1.42459447
26	VRK1	1.39289587
27	INSRR	1.37368546
28	MAP3K4	1.33677050
29	CSNK1G3	1.33335214
30	CSNK1A1L	1.30820538
31	CSNK1G2	1.28553126
32	PLK2	1.25963498
33	CSNK1G1	1.23545853
34	NTRK3	1.22232815
35	PRKCE	1.21879766
36	BRSK2	1.13967187
37	PTK2B	1.13782230
38	SRPK1	1.09061272
39	PIK3CG	1.07713263
40	DYRK2	1.05339848
41	SIK3	1.05245663
42	CAMKK2	1.04301807
43	PNCK	0.96413803
44	TAF1	0.93788633
45	FLT3	0.88086272
46	MAP2K7	0.82810865
47	DAPK2	0.80987758
48	STK39	0.79604045
49	FGFR2	0.76986470
50	CCNB1	0.73746904
51	PLK3	0.73587130
52	TEC	0.73107147
53	STK16	0.71020532
54	GRK5	0.68667925
55	MKNK2	0.67603487
56	ADRBK1	0.63977561
57	PRKD3	0.63212669
58	TNIK	0.63149332
59	ACVR1B	0.62610039
60	TXK	0.60572296
61	PKN1	0.58612905
62	MAPKAPK5	0.56974779
63	TLK1	0.56950621
64	FER	0.56921246
65	MAPK15	0.54654854
66	PRKCG	0.53597792
67	AKT3	0.52361975
68	PHKG2	0.51150165
69	PHKG1	0.51150165
70	WEE1	0.50298966
71	WNK4	0.47925088
72	CDK3	0.46941551
73	TESK2	0.45905624
74	MKNK1	0.45538551
75	ABL1	0.43307427
76	IRAK1	0.42291220
77	MAP2K6	0.41269923
78	EIF2AK3	0.39702412
79	CAMK2A	0.39543389
80	ATR	0.39189166
81	PRKCQ	0.39124251
82	TNK2	0.38934906
83	LATS1	0.38877620
84	ROCK1	0.38398816
85	DYRK1A	0.37898841
86	CSNK1A1	0.37457897
87	PRKACA	0.36184657
88	PRKAA1	0.35250167
89	GRK7	0.33617774
90	PRKCI	0.33050000
91	RPS6KA5	0.32144690
92	EPHA3	0.31620592
93	STK3	0.31380146
94	FGR	0.30212431
95	ITK	0.29534156
96	DYRK3	0.29490910
97	IGF1R	0.29054553
98	RAF1	0.28600003
99	NME1	0.26985495
100	MAP3K12	0.26901570

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.23318322
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.02598097
3	Protein export_Homo sapiens_hsa03060	2.71119521
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.64936851
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.64388556
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.55046501
7	Butanoate metabolism_Homo sapiens_hsa00650	2.46298966
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.32469964
9	Propanoate metabolism_Homo sapiens_hsa00640	2.17307601
10	RNA polymerase_Homo sapiens_hsa03020	2.17050861
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.17031545
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.12338300
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.06126210
14	Fanconi anemia pathway_Homo sapiens_hsa03460	2.03352847
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.94778335
16	Nicotine addiction_Homo sapiens_hsa05033	1.81106684
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.79606947
18	Caffeine metabolism_Homo sapiens_hsa00232	1.75111898
19	Basal transcription factors_Homo sapiens_hsa03022	1.73267495
20	Non-homologous end-joining_Homo sapiens_hsa03450	1.71866049
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.70412183
22	Homologous recombination_Homo sapiens_hsa03440	1.67748257
23	Olfactory transduction_Homo sapiens_hsa04740	1.62600471
24	Oxidative phosphorylation_Homo sapiens_hsa00190	1.50158060
25	RNA degradation_Homo sapiens_hsa03018	1.49687296
26	Taste transduction_Homo sapiens_hsa04742	1.45880932
27	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.44863956
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.39568316
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.34054384
30	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.33151322
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.22304480
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.20055545
33	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.17997977
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.17153213
35	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.16058242
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.14714266
37	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.14177854
38	Fatty acid elongation_Homo sapiens_hsa00062	1.14015222
39	Base excision repair_Homo sapiens_hsa03410	1.13767398
40	Peroxisome_Homo sapiens_hsa04146	1.12569040
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.12290051
42	Regulation of autophagy_Homo sapiens_hsa04140	1.12069244
43	Retinol metabolism_Homo sapiens_hsa00830	1.11044032
44	beta-Alanine metabolism_Homo sapiens_hsa00410	1.10393255
45	Collecting duct acid secretion_Homo sapiens_hsa04966	1.06900479
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.03715019
47	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.02639842
48	Parkinsons disease_Homo sapiens_hsa05012	1.02594635
49	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.99085182
50	Asthma_Homo sapiens_hsa05310	0.94758122
51	One carbon pool by folate_Homo sapiens_hsa00670	0.94750879
52	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.90034822
53	Glycerolipid metabolism_Homo sapiens_hsa00561	0.87156492
54	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.86729003
55	Proteasome_Homo sapiens_hsa03050	0.85038448
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.84005763
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.82102425
58	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.81685468
59	Metabolic pathways_Homo sapiens_hsa01100	0.76491566
60	ABC transporters_Homo sapiens_hsa02010	0.75378329
61	Primary immunodeficiency_Homo sapiens_hsa05340	0.75304768
62	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.73546658
63	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.72798354
64	Morphine addiction_Homo sapiens_hsa05032	0.72559711
65	Steroid biosynthesis_Homo sapiens_hsa00100	0.72470284
66	GABAergic synapse_Homo sapiens_hsa04727	0.71491812
67	Huntingtons disease_Homo sapiens_hsa05016	0.70761574
68	Pyrimidine metabolism_Homo sapiens_hsa00240	0.69915149
69	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.69798333
70	Purine metabolism_Homo sapiens_hsa00230	0.69270772
71	Type I diabetes mellitus_Homo sapiens_hsa04940	0.68995704
72	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.65738832
73	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.59017966
74	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.58981337
75	Salivary secretion_Homo sapiens_hsa04970	0.58823393
76	RNA transport_Homo sapiens_hsa03013	0.55369547
77	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.54914062
78	Mineral absorption_Homo sapiens_hsa04978	0.53515195
79	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.51042280
80	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.49565451
81	Serotonergic synapse_Homo sapiens_hsa04726	0.49476800
82	Glutamatergic synapse_Homo sapiens_hsa04724	0.48210449
83	Rheumatoid arthritis_Homo sapiens_hsa05323	0.47611154
84	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.46328017
85	Circadian rhythm_Homo sapiens_hsa04710	0.45363558
86	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.42576811
87	Fat digestion and absorption_Homo sapiens_hsa04975	0.41852071
88	Circadian entrainment_Homo sapiens_hsa04713	0.41156331
89	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40870135
90	Calcium signaling pathway_Homo sapiens_hsa04020	0.38958415
91	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.38508124
92	Alzheimers disease_Homo sapiens_hsa05010	0.38274808
93	Fatty acid degradation_Homo sapiens_hsa00071	0.37216517
94	Nucleotide excision repair_Homo sapiens_hsa03420	0.35444310
95	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.34747085
96	Glutathione metabolism_Homo sapiens_hsa00480	0.34368740
97	Allograft rejection_Homo sapiens_hsa05330	0.34366975
98	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.34290028
99	Insulin secretion_Homo sapiens_hsa04911	0.33187378
100	Arginine and proline metabolism_Homo sapiens_hsa00330	0.31976160

OR10V3P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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