OR11A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tryptophan catabolic process (GO:0006569)4.87340712
2indole-containing compound catabolic process (GO:0042436)4.87340712
3indolalkylamine catabolic process (GO:0046218)4.87340712
4kynurenine metabolic process (GO:0070189)4.76213703
5detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.67605306
6indolalkylamine metabolic process (GO:0006586)4.61770761
7tryptophan metabolic process (GO:0006568)4.19666254
8cilium or flagellum-dependent cell motility (GO:0001539)4.18242147
9regulation of memory T cell differentiation (GO:0043380)4.10470637
10signal peptide processing (GO:0006465)3.94314998
11fucose catabolic process (GO:0019317)3.83186215
12L-fucose metabolic process (GO:0042354)3.83186215
13L-fucose catabolic process (GO:0042355)3.83186215
14photoreceptor cell maintenance (GO:0045494)3.77789211
15L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.68724784
16behavioral response to nicotine (GO:0035095)3.67632231
17neural tube formation (GO:0001841)3.63992641
18behavioral response to ethanol (GO:0048149)3.63120198
19regulation of gene silencing by miRNA (GO:0060964)3.61343081
20regulation of gene silencing by RNA (GO:0060966)3.61343081
21regulation of posttranscriptional gene silencing (GO:0060147)3.61343081
22detection of light stimulus involved in sensory perception (GO:0050962)3.60653246
23detection of light stimulus involved in visual perception (GO:0050908)3.60653246
24reflex (GO:0060004)3.58827469
25auditory receptor cell stereocilium organization (GO:0060088)3.57628883
26regulation of hippo signaling (GO:0035330)3.56579914
27indole-containing compound metabolic process (GO:0042430)3.53775394
28retinal cone cell development (GO:0046549)3.53470834
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.46731733
30gamma-aminobutyric acid transport (GO:0015812)3.35053949
31NAD biosynthetic process (GO:0009435)3.34437111
32regulation of establishment of cell polarity (GO:2000114)3.33529580
33piRNA metabolic process (GO:0034587)3.26298338
34negative regulation of cytosolic calcium ion concentration (GO:0051481)3.25974414
35tachykinin receptor signaling pathway (GO:0007217)3.24414676
36inner ear receptor stereocilium organization (GO:0060122)3.24288042
37negative regulation of mast cell activation (GO:0033004)3.22864741
38cellular biogenic amine catabolic process (GO:0042402)3.20345248
39amine catabolic process (GO:0009310)3.20345248
40cellular ketone body metabolic process (GO:0046950)3.18295611
41detection of mechanical stimulus involved in sensory perception (GO:0050974)3.16869986
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.15653701
43L-methionine salvage (GO:0071267)3.12971055
44L-methionine biosynthetic process (GO:0071265)3.12971055
45amino acid salvage (GO:0043102)3.12971055
46response to pheromone (GO:0019236)3.09178495
47regulation of sarcomere organization (GO:0060297)3.06718089
48protein localization to cilium (GO:0061512)3.05086598
49axoneme assembly (GO:0035082)2.98667297
50benzene-containing compound metabolic process (GO:0042537)2.98369923
51neuronal action potential (GO:0019228)2.95581419
52regulation of meiosis I (GO:0060631)2.95071531
53aromatic amino acid family catabolic process (GO:0009074)2.94017198
54serotonin metabolic process (GO:0042428)2.93426146
55negative regulation of multicellular organism growth (GO:0040015)2.91818514
56primary amino compound metabolic process (GO:1901160)2.91234615
57cilium movement (GO:0003341)2.90980918
58ketone body metabolic process (GO:1902224)2.88100151
59negative regulation of calcium ion transport into cytosol (GO:0010523)2.84737998
60sulfation (GO:0051923)2.84442395
61sex differentiation (GO:0007548)2.82002136
62regulation of establishment or maintenance of cell polarity (GO:0032878)2.81771071
63establishment of protein localization to Golgi (GO:0072600)2.81748989
64acrosome assembly (GO:0001675)2.75974094
65positive regulation of developmental pigmentation (GO:0048087)2.75009353
66cilium organization (GO:0044782)2.74814797
67proline transport (GO:0015824)2.72622998
68righting reflex (GO:0060013)2.72536630
69regulation of action potential (GO:0098900)2.70523006
70epithelial cilium movement (GO:0003351)2.70344437
71cilium assembly (GO:0042384)2.68895697
72neuronal action potential propagation (GO:0019227)2.66501050
73methionine biosynthetic process (GO:0009086)2.65554897
74cornea development in camera-type eye (GO:0061303)2.64364670
75cellular response to sterol (GO:0036315)2.64120735
76flavonoid metabolic process (GO:0009812)2.63199462
77phosphatidylinositol acyl-chain remodeling (GO:0036149)2.62822737
78nonmotile primary cilium assembly (GO:0035058)2.62370589
79cilium morphogenesis (GO:0060271)2.61439611
80aromatic amino acid family metabolic process (GO:0009072)2.61101463
81ADP metabolic process (GO:0046031)2.60638374
82double-strand break repair via homologous recombination (GO:0000724)2.59918001
83photoreceptor cell development (GO:0042461)2.59908994
84recombinational repair (GO:0000725)2.59417736
85regulation of MHC class I biosynthetic process (GO:0045343)2.58465272
86adenosine metabolic process (GO:0046085)2.56136842
87regulation of collateral sprouting (GO:0048670)2.55879464
88positive regulation of oligodendrocyte differentiation (GO:0048714)2.55550198
89regulation of pigment cell differentiation (GO:0050932)2.55478407
90replication fork processing (GO:0031297)2.54560383
91platelet dense granule organization (GO:0060155)2.53731299
92one-carbon compound transport (GO:0019755)2.53577555
93membrane depolarization during action potential (GO:0086010)2.49623864
94positive regulation of vasculogenesis (GO:2001214)2.48332257
95rhodopsin mediated signaling pathway (GO:0016056)2.48198718
96nicotinamide nucleotide biosynthetic process (GO:0019359)2.47444108
97pyridine nucleotide biosynthetic process (GO:0019363)2.47444108
98regulation of rhodopsin mediated signaling pathway (GO:0022400)2.45768856
99central nervous system neuron axonogenesis (GO:0021955)2.43363159
100sphingoid metabolic process (GO:0046519)2.42387051

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.36052198
2VDR_22108803_ChIP-Seq_LS180_Human3.31917787
3EZH2_22144423_ChIP-Seq_EOC_Human3.02476885
4ZNF274_21170338_ChIP-Seq_K562_Hela2.99117967
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.95866654
6IGF1R_20145208_ChIP-Seq_DFB_Human2.95530661
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.89242466
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.83618789
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.61817615
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.60468233
11TAF15_26573619_Chip-Seq_HEK293_Human2.38774769
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.22164017
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.20179327
14P300_19829295_ChIP-Seq_ESCs_Human2.13700012
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.13033439
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12082953
17ER_23166858_ChIP-Seq_MCF-7_Human2.05776316
18FUS_26573619_Chip-Seq_HEK293_Human2.05181155
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.00968775
20BCAT_22108803_ChIP-Seq_LS180_Human1.98795804
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.94494964
22EWS_26573619_Chip-Seq_HEK293_Human1.93434398
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.91402959
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.85197319
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84440267
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.83038492
27SMAD4_21799915_ChIP-Seq_A2780_Human1.81790821
28STAT3_23295773_ChIP-Seq_U87_Human1.77697732
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72942321
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70473814
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70399499
32CBP_20019798_ChIP-Seq_JUKART_Human1.67427941
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.67427941
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.67096480
35TCF4_23295773_ChIP-Seq_U87_Human1.61162629
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60912386
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.60912386
38AR_25329375_ChIP-Seq_VCAP_Human1.60366726
39AR_21572438_ChIP-Seq_LNCaP_Human1.59072444
40NR3C1_21868756_ChIP-Seq_MCF10A_Human1.53033547
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50603246
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49104851
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48518574
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.47389255
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46657486
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42708562
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41804489
48TCF4_22108803_ChIP-Seq_LS180_Human1.40187118
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40139822
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39435637
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36981849
52RUNX2_22187159_ChIP-Seq_PCA_Human1.34608212
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.34435646
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33443620
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33138767
56SOX2_19829295_ChIP-Seq_ESCs_Human1.32458472
57NANOG_19829295_ChIP-Seq_ESCs_Human1.32458472
58PRDM14_20953172_ChIP-Seq_ESCs_Human1.31146238
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30112317
60SMAD4_21741376_ChIP-Seq_EPCs_Human1.27618703
61KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27597431
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27464388
63TP53_22573176_ChIP-Seq_HFKS_Human1.26385159
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.25989430
65FLI1_21867929_ChIP-Seq_TH2_Mouse1.23523886
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.23361225
67REST_21632747_ChIP-Seq_MESCs_Mouse1.23240570
68CDX2_22108803_ChIP-Seq_LS180_Human1.20915464
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20364923
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.19592901
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19097611
72* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15762642
73ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15300531
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14892170
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.14892170
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.13927435
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13921173
78DROSHA_22980978_ChIP-Seq_HELA_Human1.13353837
79P53_22387025_ChIP-Seq_ESCs_Mouse1.10419057
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10401428
81TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08761740
82RNF2_27304074_Chip-Seq_NSC_Mouse1.08027643
83KDM2B_26808549_Chip-Seq_REH_Human1.07176945
84TAL1_26923725_Chip-Seq_HPCs_Mouse1.06919635
85E2F1_18555785_Chip-Seq_ESCs_Mouse1.06794725
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05072615
87SOX2_21211035_ChIP-Seq_LN229_Gbm1.04776242
88STAT3_18555785_Chip-Seq_ESCs_Mouse1.02621578
89AR_20517297_ChIP-Seq_VCAP_Human1.01772557
90NCOR_22424771_ChIP-Seq_293T_Human1.01633498
91TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01085503
92BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00715420
93OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00658228
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00200094
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99886900
96RXR_22108803_ChIP-Seq_LS180_Human0.99417128
97ARNT_22903824_ChIP-Seq_MCF-7_Human0.98969486
98CMYC_18555785_Chip-Seq_ESCs_Mouse0.98283209
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97722937
100FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97647132

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.41330879
2MP0003195_calcinosis3.17612794
3MP0001968_abnormal_touch/_nociception3.09834292
4MP0002736_abnormal_nociception_after2.92357794
5MP0001501_abnormal_sleep_pattern2.78053175
6MP0009046_muscle_twitch2.70849891
7MP0005551_abnormal_eye_electrophysiolog2.69844887
8MP0003646_muscle_fatigue2.50837120
9MP0009745_abnormal_behavioral_response2.23585357
10MP0008877_abnormal_DNA_methylation2.22272563
11MP0005253_abnormal_eye_physiology2.13152231
12MP0002837_dystrophic_cardiac_calcinosis2.04567411
13MP0006276_abnormal_autonomic_nervous2.00866753
14MP0003880_abnormal_central_pattern1.95388242
15MP0005646_abnormal_pituitary_gland1.94262891
16MP0004043_abnormal_pH_regulation1.93453852
17MP0003136_yellow_coat_color1.93349140
18MP0006292_abnormal_olfactory_placode1.91418861
19MP0008872_abnormal_physiological_respon1.90929983
20MP0001986_abnormal_taste_sensitivity1.89576580
21MP0003011_delayed_dark_adaptation1.81950643
22MP0001486_abnormal_startle_reflex1.80774572
23MP0002272_abnormal_nervous_system1.80723703
24MP0002102_abnormal_ear_morphology1.80275113
25MP0002735_abnormal_chemical_nociception1.80044767
26MP0000427_abnormal_hair_cycle1.75089286
27MP0006072_abnormal_retinal_apoptosis1.71393375
28MP0000372_irregular_coat_pigmentation1.67733977
29MP0001984_abnormal_olfaction1.57609671
30MP0003252_abnormal_bile_duct1.56822493
31MP0005410_abnormal_fertilization1.54485977
32MP0005075_abnormal_melanosome_morpholog1.52379321
33MP0001485_abnormal_pinna_reflex1.49671805
34MP0002938_white_spotting1.49468527
35MP0002234_abnormal_pharynx_morphology1.48548624
36MP0004147_increased_porphyrin_level1.46545424
37MP0002733_abnormal_thermal_nociception1.45139691
38MP0005174_abnormal_tail_pigmentation1.44647913
39MP0002064_seizures1.44384743
40MP0002572_abnormal_emotion/affect_behav1.44092586
41MP0005645_abnormal_hypothalamus_physiol1.39219250
42MP0001970_abnormal_pain_threshold1.37381769
43MP0002876_abnormal_thyroid_physiology1.35740958
44MP0000631_abnormal_neuroendocrine_gland1.34426741
45MP0004145_abnormal_muscle_electrophysio1.32937342
46MP0010386_abnormal_urinary_bladder1.32565274
47MP0005171_absent_coat_pigmentation1.25795610
48MP0003635_abnormal_synaptic_transmissio1.25664051
49MP0005670_abnormal_white_adipose1.25517168
50MP0003787_abnormal_imprinting1.24971938
51MP0002095_abnormal_skin_pigmentation1.23567044
52MP0002067_abnormal_sensory_capabilities1.23185612
53MP0004215_abnormal_myocardial_fiber1.20666635
54MP0000383_abnormal_hair_follicle1.19826404
55MP0003718_maternal_effect1.18222761
56MP0004142_abnormal_muscle_tone1.16392983
57MP0002557_abnormal_social/conspecific_i1.16340708
58MP0002653_abnormal_ependyma_morphology1.16276637
59MP0004742_abnormal_vestibular_system1.15483312
60MP0000371_diluted_coat_color1.14322836
61MP0003950_abnormal_plasma_membrane1.10852677
62MP0005085_abnormal_gallbladder_physiolo1.09596754
63MP0002734_abnormal_mechanical_nocicepti1.06321064
64MP0002928_abnormal_bile_duct1.03787220
65MP0004924_abnormal_behavior1.01587158
66MP0005386_behavior/neurological_phenoty1.01587158
67MP0002138_abnormal_hepatobiliary_system1.00813832
68MP0008057_abnormal_DNA_replication1.00111405
69MP0002063_abnormal_learning/memory/cond0.99614137
70MP0005195_abnormal_posterior_eye0.98647031
71MP0003698_abnormal_male_reproductive0.98303649
72MP0000230_abnormal_systemic_arterial0.97481177
73MP0008875_abnormal_xenobiotic_pharmacok0.96215855
74MP0002229_neurodegeneration0.95705089
75MP0003137_abnormal_impulse_conducting0.93712328
76MP0003045_fibrosis0.93395935
77MP0004133_heterotaxia0.93156128
78MP0002638_abnormal_pupillary_reflex0.92040026
79MP0004885_abnormal_endolymph0.91525706
80MP0005084_abnormal_gallbladder_morpholo0.89125789
81MP0003878_abnormal_ear_physiology0.88468293
82MP0005377_hearing/vestibular/ear_phenot0.88468293
83MP0001905_abnormal_dopamine_level0.86615405
84MP0003633_abnormal_nervous_system0.85615679
85MP0005423_abnormal_somatic_nervous0.85205822
86MP0000026_abnormal_inner_ear0.84793454
87MP0002752_abnormal_somatic_nervous0.84414899
88MP0001963_abnormal_hearing_physiology0.84405465
89MP0005647_abnormal_sex_gland0.83280391
90MP0003890_abnormal_embryonic-extraembry0.82615452
91MP0008058_abnormal_DNA_repair0.82067399
92MP0003119_abnormal_digestive_system0.81655689
93MP0008789_abnormal_olfactory_epithelium0.81211043
94MP0002254_reproductive_system_inflammat0.81198309
95MP0001529_abnormal_vocalization0.80301983
96MP0002184_abnormal_innervation0.75016510
97MP0002751_abnormal_autonomic_nervous0.74844219
98MP0005167_abnormal_blood-brain_barrier0.73326162
99MP0004085_abnormal_heartbeat0.72617698
100MP0005310_abnormal_salivary_gland0.72068829

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)4.83679498
2Progressive cerebellar ataxia (HP:0002073)4.58383750
3Pancreatic cysts (HP:0001737)4.36342087
4Gaze-evoked nystagmus (HP:0000640)4.03473459
5Pancreatic fibrosis (HP:0100732)3.90192723
6Congenital stationary night blindness (HP:0007642)3.82852690
7True hermaphroditism (HP:0010459)3.72567788
8Hyperventilation (HP:0002883)3.72108013
9Attenuation of retinal blood vessels (HP:0007843)3.56200505
10Abnormality of midbrain morphology (HP:0002418)3.48459237
11Molar tooth sign on MRI (HP:0002419)3.48459237
12Nephronophthisis (HP:0000090)3.20766416
13Cystic liver disease (HP:0006706)3.16612872
14Abolished electroretinogram (ERG) (HP:0000550)3.09381506
15Abnormality of the renal cortex (HP:0011035)3.06584002
16Medial flaring of the eyebrow (HP:0010747)3.01146867
17Chronic hepatic failure (HP:0100626)2.94359806
18Febrile seizures (HP:0002373)2.94260052
19Abnormality of the renal medulla (HP:0100957)2.93914114
20Focal seizures (HP:0007359)2.91940289
21Congenital sensorineural hearing impairment (HP:0008527)2.85278385
22Keratoconus (HP:0000563)2.84756420
23Increased corneal curvature (HP:0100692)2.84756420
24Pendular nystagmus (HP:0012043)2.83491670
25Focal motor seizures (HP:0011153)2.82769917
26Bony spicule pigmentary retinopathy (HP:0007737)2.80518890
27Type II lissencephaly (HP:0007260)2.69286235
28Dialeptic seizures (HP:0011146)2.68353409
29Inability to walk (HP:0002540)2.65546963
30Decreased central vision (HP:0007663)2.60181939
31Protruding tongue (HP:0010808)2.58196722
32Absent/shortened dynein arms (HP:0200106)2.53393089
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.53393089
34Clumsiness (HP:0002312)2.52238564
35Progressive inability to walk (HP:0002505)2.49303231
36Sclerocornea (HP:0000647)2.47385764
37Abnormal ciliary motility (HP:0012262)2.46980638
38Prostate neoplasm (HP:0100787)2.45186449
39Aplasia/Hypoplasia of the tibia (HP:0005772)2.44160246
40Absence seizures (HP:0002121)2.42917057
41Hemiparesis (HP:0001269)2.42795416
42Abnormality of macular pigmentation (HP:0008002)2.40792407
43Stomach cancer (HP:0012126)2.38484908
44Gait imbalance (HP:0002141)2.31296221
45Polydipsia (HP:0001959)2.27808426
46Abnormal drinking behavior (HP:0030082)2.27808426
47Abnormality of the labia minora (HP:0012880)2.27773459
48Fair hair (HP:0002286)2.26862594
49Renal cortical cysts (HP:0000803)2.24300912
50Congenital primary aphakia (HP:0007707)2.23005844
51Absent rod-and cone-mediated responses on ERG (HP:0007688)2.20283385
52Retinal dysplasia (HP:0007973)2.20172683
53Absent speech (HP:0001344)2.18006829
54Congenital hepatic fibrosis (HP:0002612)2.17737215
55Aplasia/Hypoplasia of the tongue (HP:0010295)2.17123772
56Tubular atrophy (HP:0000092)2.17012560
57Abnormal rod and cone electroretinograms (HP:0008323)2.15996853
58Large for gestational age (HP:0001520)2.12765061
59Colon cancer (HP:0003003)2.10156277
60Nephrogenic diabetes insipidus (HP:0009806)2.09674970
61Decreased electroretinogram (ERG) amplitude (HP:0000654)2.08985551
62Chorioretinal atrophy (HP:0000533)2.08016965
63Intestinal atresia (HP:0011100)2.07944168
64Bile duct proliferation (HP:0001408)2.05895932
65Abnormal biliary tract physiology (HP:0012439)2.05895932
66Furrowed tongue (HP:0000221)2.04871254
67Genital tract atresia (HP:0001827)2.03691710
68Abnormal respiratory motile cilium physiology (HP:0012261)2.03298291
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02801696
70Abnormality of alanine metabolism (HP:0010916)2.02801696
71Hyperalaninemia (HP:0003348)2.02801696
72Broad-based gait (HP:0002136)2.02183607
73Small hand (HP:0200055)2.01893397
74Constricted visual fields (HP:0001133)1.98292542
75Thyroid-stimulating hormone excess (HP:0002925)1.96329185
76Aplasia/Hypoplasia of the uvula (HP:0010293)1.96109492
77Lissencephaly (HP:0001339)1.92269785
78Cerebellar dysplasia (HP:0007033)1.91440831
79Hypoplasia of the fovea (HP:0007750)1.89981455
80Aplasia/Hypoplasia of the fovea (HP:0008060)1.89981455
81Vaginal atresia (HP:0000148)1.89471810
82Retinitis pigmentosa (HP:0000510)1.88617444
83Postaxial foot polydactyly (HP:0001830)1.88188815
84Abnormal respiratory epithelium morphology (HP:0012253)1.86121115
85Abnormal respiratory motile cilium morphology (HP:0005938)1.86121115
86Severe visual impairment (HP:0001141)1.83694050
87Abnormality of the hepatic vasculature (HP:0006707)1.81241680
88Ketoacidosis (HP:0001993)1.79119590
89Polyuria (HP:0000103)1.78403638
90Generalized hypopigmentation of hair (HP:0011358)1.78321641
91Birth length less than 3rd percentile (HP:0003561)1.78064860
923-Methylglutaconic aciduria (HP:0003535)1.76554359
93Action tremor (HP:0002345)1.76440315
94Abnormality of the prostate (HP:0008775)1.76326694
95Ketosis (HP:0001946)1.75106795
96Congenital, generalized hypertrichosis (HP:0004540)1.74506400
97Central scotoma (HP:0000603)1.74171950
98Anencephaly (HP:0002323)1.71590480
99Hypothermia (HP:0002045)1.71221328
100Macular degeneration (HP:0000608)1.70999347

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.33380648
2MAP4K23.17429498
3BMPR1B3.10789711
4ACVR1B3.01721774
5ADRBK22.88238527
6CDK192.67806125
7INSRR2.40372878
8GRK12.39885621
9WNK32.24679767
10OXSR12.16389711
11NUAK12.15992651
12ZAK2.09220416
13PINK11.80183671
14MAPK131.80047170
15MAP3K41.65520834
16STK38L1.58913223
17NTRK31.53625557
18CASK1.49750999
19LATS11.49100076
20TXK1.43570361
21MKNK21.37347372
22TAOK31.33297333
23TRIM281.26236690
24DAPK21.23927953
25MARK11.22130351
26STK31.17076423
27ADRBK11.14478034
28TNIK1.06421264
29MAP2K71.05344326
30WNK40.99810571
31PRKCE0.98753569
32PTK2B0.96828163
33TNK20.94205597
34STK390.94024233
35BCR0.93123542
36MUSK0.92335846
37PAK30.91830504
38MKNK10.90162477
39PRKCG0.88865361
40PNCK0.88283276
41TGFBR10.85510558
42TEC0.80669669
43PIK3CG0.73815116
44AKT30.70328327
45CSNK1G10.70327493
46FER0.69947965
47CSNK1G20.69396431
48EIF2AK30.68277260
49TAF10.67202257
50CSNK1A1L0.67090709
51BRSK20.66120387
52PRKAA20.65221556
53CSNK1G30.63718802
54CAMK2A0.62113903
55FGFR20.59288658
56ERBB30.57745421
57SGK20.55207509
58TIE10.54833334
59PKN10.54622194
60IKBKB0.52886559
61KIT0.52380542
62EPHA40.52299259
63IRAK10.51207279
64SIK20.48687263
65PLK20.46666880
66STK110.44996359
67VRK10.44648486
68STK380.44271648
69MAP3K70.44206848
70CHUK0.43424598
71BCKDK0.43240593
72PHKG20.42282680
73PHKG10.42282680
74CAMKK20.41651759
75ITK0.41355890
76MAP2K60.41320433
77DYRK20.40593904
78PLK40.39950380
79MAPKAPK50.39946287
80PRKACA0.39716119
81BMPR20.38606951
82CSNK1D0.36994064
83PIK3CA0.36788802
84PRKG10.36412051
85PRKAA10.35734710
86FLT30.35268567
87OBSCN0.35113281
88CSNK1A10.34346788
89MAPKAPK30.34103846
90NLK0.33421975
91CHEK20.32879973
92PRKCA0.32273862
93PRKCQ0.32202693
94EPHA30.31414705
95NTRK20.29865788
96PRKCZ0.29152677
97ATR0.28750750
98MAP2K10.28256206
99CSF1R0.27435538
100PRKACB0.27021476

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.06682132
2Butanoate metabolism_Homo sapiens_hsa006502.77993516
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.56187213
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.50928239
5Linoleic acid metabolism_Homo sapiens_hsa005912.48496271
6Nicotine addiction_Homo sapiens_hsa050332.43135226
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.40178495
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.30308981
9Homologous recombination_Homo sapiens_hsa034402.19464512
10Tryptophan metabolism_Homo sapiens_hsa003802.13647265
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.04281539
12Taste transduction_Homo sapiens_hsa047422.01427598
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.97972345
14Ether lipid metabolism_Homo sapiens_hsa005651.92043128
15Nitrogen metabolism_Homo sapiens_hsa009101.89264143
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.85974840
17ABC transporters_Homo sapiens_hsa020101.83517330
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.82584619
19Morphine addiction_Homo sapiens_hsa050321.74725839
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.68958304
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.67439661
22Propanoate metabolism_Homo sapiens_hsa006401.66881948
23* Olfactory transduction_Homo sapiens_hsa047401.65503895
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.59102019
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.57986909
26Protein export_Homo sapiens_hsa030601.56569094
27Fanconi anemia pathway_Homo sapiens_hsa034601.50002798
28Caffeine metabolism_Homo sapiens_hsa002321.48554670
29Circadian entrainment_Homo sapiens_hsa047131.48475949
30GABAergic synapse_Homo sapiens_hsa047271.47025247
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43370355
32Retinol metabolism_Homo sapiens_hsa008301.40811167
33Selenocompound metabolism_Homo sapiens_hsa004501.40437235
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.39637621
35Glutamatergic synapse_Homo sapiens_hsa047241.38731724
36Salivary secretion_Homo sapiens_hsa049701.30502203
37Chemical carcinogenesis_Homo sapiens_hsa052041.28194364
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.27206712
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25903626
40Asthma_Homo sapiens_hsa053101.19458753
41Histidine metabolism_Homo sapiens_hsa003401.19300372
42Serotonergic synapse_Homo sapiens_hsa047261.15368347
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07664340
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07617006
45Basal transcription factors_Homo sapiens_hsa030221.05820369
46Arachidonic acid metabolism_Homo sapiens_hsa005901.04025727
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02140481
48Long-term depression_Homo sapiens_hsa047300.98575842
49Insulin secretion_Homo sapiens_hsa049110.98270736
50beta-Alanine metabolism_Homo sapiens_hsa004100.97387960
51Glycerolipid metabolism_Homo sapiens_hsa005610.92879872
52Ovarian steroidogenesis_Homo sapiens_hsa049130.86090845
53RNA polymerase_Homo sapiens_hsa030200.85995065
54Calcium signaling pathway_Homo sapiens_hsa040200.84855752
55Dorso-ventral axis formation_Homo sapiens_hsa043200.83589763
56Peroxisome_Homo sapiens_hsa041460.83389137
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80149479
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.76326580
59Gastric acid secretion_Homo sapiens_hsa049710.70956955
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70450970
61Graft-versus-host disease_Homo sapiens_hsa053320.69052852
62Non-homologous end-joining_Homo sapiens_hsa034500.67503463
63Sphingolipid metabolism_Homo sapiens_hsa006000.66217734
64Fat digestion and absorption_Homo sapiens_hsa049750.65521028
65Circadian rhythm_Homo sapiens_hsa047100.64555849
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64117198
67One carbon pool by folate_Homo sapiens_hsa006700.63869362
68Dopaminergic synapse_Homo sapiens_hsa047280.58248516
69Purine metabolism_Homo sapiens_hsa002300.58214790
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.56668539
71Fatty acid biosynthesis_Homo sapiens_hsa000610.55565046
72Renin secretion_Homo sapiens_hsa049240.55463435
73Regulation of autophagy_Homo sapiens_hsa041400.53897299
74Fatty acid degradation_Homo sapiens_hsa000710.53672180
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53511239
76Type I diabetes mellitus_Homo sapiens_hsa049400.53297255
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.51511433
78Autoimmune thyroid disease_Homo sapiens_hsa053200.51156804
79cAMP signaling pathway_Homo sapiens_hsa040240.49455600
80Oxytocin signaling pathway_Homo sapiens_hsa049210.49077405
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48493254
82Cholinergic synapse_Homo sapiens_hsa047250.46478853
83Metabolic pathways_Homo sapiens_hsa011000.46181560
84Cocaine addiction_Homo sapiens_hsa050300.45692950
85Pancreatic secretion_Homo sapiens_hsa049720.42753033
86Oxidative phosphorylation_Homo sapiens_hsa001900.40796222
87Allograft rejection_Homo sapiens_hsa053300.40404885
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38925962
89Lysine degradation_Homo sapiens_hsa003100.34851108
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31873869
91RNA degradation_Homo sapiens_hsa030180.30848679
92Fatty acid metabolism_Homo sapiens_hsa012120.30394823
93Hedgehog signaling pathway_Homo sapiens_hsa043400.30293742
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29632169
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.27268396
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27206349
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25836245
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.25639913
99Amphetamine addiction_Homo sapiens_hsa050310.22096720
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21888104

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