OR11G1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of RNA splicing (GO:0033120)9.69391945
2seminiferous tubule development (GO:0072520)9.52579953
3negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)9.19215055
4cAMP biosynthetic process (GO:0006171)8.82124274
5detection of chemical stimulus involved in sensory perception (GO:0050907)8.45851473
6negative regulation of alpha-beta T cell differentiation (GO:0046639)8.36565187
7enteric nervous system development (GO:0048484)7.87161415
8regulation of protein sumoylation (GO:0033233)7.50810525
9synaptic transmission, dopaminergic (GO:0001963)7.11051605
10dendritic spine morphogenesis (GO:0060997)6.95965022
11positive regulation of mitochondrial fission (GO:0090141)6.93501400
12righting reflex (GO:0060013)6.89136613
13heterotypic cell-cell adhesion (GO:0034113)6.53777741
14positive regulation of T-helper 1 type immune response (GO:0002827)6.31001652
15detection of chemical stimulus (GO:0009593)6.10819531
16hepatocyte apoptotic process (GO:0097284)6.09740353
17icosanoid secretion (GO:0032309)6.02965212
18arachidonic acid secretion (GO:0050482)6.02965212
19endothelial cell differentiation (GO:0045446)5.91655391
20positive regulation of T-helper cell differentiation (GO:0045624)5.78956570
21phosphatidylinositol acyl-chain remodeling (GO:0036149)5.46986132
22drug transmembrane transport (GO:0006855)5.26159928
23regulation of mitochondrial fission (GO:0090140)5.12520791
24phosphatidylserine acyl-chain remodeling (GO:0036150)5.09908276
25phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.99620137
26neuronal ion channel clustering (GO:0045161)4.99347011
27fatty acid derivative transport (GO:1901571)4.99165275
28icosanoid transport (GO:0071715)4.99165275
29negative regulation of alpha-beta T cell activation (GO:0046636)4.87005140
30neural tube formation (GO:0001841)4.80905969
31chemosensory behavior (GO:0007635)4.75938209
32hyaluronan catabolic process (GO:0030214)4.69436621
33regulation of T-helper 1 type immune response (GO:0002825)4.54353695
34cilium or flagellum-dependent cell motility (GO:0001539)4.53487017
35embryonic digestive tract morphogenesis (GO:0048557)4.45805036
36positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.42166911
37cyclic purine nucleotide metabolic process (GO:0052652)4.39840513
38nephron tubule morphogenesis (GO:0072078)4.33488169
39nephron epithelium morphogenesis (GO:0072088)4.33488169
40ATP hydrolysis coupled proton transport (GO:0015991)4.32221295
41energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.32221295
42vocalization behavior (GO:0071625)4.30643627
43leukotriene biosynthetic process (GO:0019370)4.29785901
44retina layer formation (GO:0010842)4.29043518
45cyclic nucleotide biosynthetic process (GO:0009190)4.25260409
46positive regulation of membrane potential (GO:0045838)4.24161994
47attachment of spindle microtubules to kinetochore (GO:0008608)4.23275721
48regulation of T-helper cell differentiation (GO:0045622)4.22162908
49cellular response to glucagon stimulus (GO:0071377)4.20009694
50response to dietary excess (GO:0002021)4.19034578
51regulation of type 2 immune response (GO:0002828)4.17594833
52regulation of cAMP-mediated signaling (GO:0043949)4.17463955
53negative regulation of actin filament bundle assembly (GO:0032232)4.14988887
54water transport (GO:0006833)4.08303668
55cAMP metabolic process (GO:0046058)3.98782768
56mitochondrial fusion (GO:0008053)3.97684750
57protein localization to synapse (GO:0035418)3.96358228
58dendritic spine organization (GO:0097061)3.96143078
59positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.89883149
60cytoskeletal anchoring at plasma membrane (GO:0007016)3.82534536
61negative regulation of cytosolic calcium ion concentration (GO:0051481)3.81577996
62monoamine transport (GO:0015844)3.75256631
63cellular zinc ion homeostasis (GO:0006882)3.74938060
64negative regulation of T cell differentiation (GO:0045581)3.69195583
65fluid transport (GO:0042044)3.64686322
66drug transport (GO:0015893)3.61244624
67phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.60485091
68positive regulation of protein targeting to membrane (GO:0090314)3.51114432
69cellular response to ATP (GO:0071318)3.48877756
70pre-miRNA processing (GO:0031054)3.48180031
71sequestering of metal ion (GO:0051238)3.45314648
72sulfur amino acid catabolic process (GO:0000098)3.44460849
73negative regulation of homotypic cell-cell adhesion (GO:0034111)3.39825082
74positive regulation of alpha-beta T cell differentiation (GO:0046638)3.34624143
75positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.33587659
76regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.33300051
77left/right axis specification (GO:0070986)3.28291205
78negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.19756358
79phosphatidylcholine acyl-chain remodeling (GO:0036151)3.15144628
80response to glucagon (GO:0033762)3.13543936
81neuromuscular process controlling posture (GO:0050884)3.12242936
82renal tubule morphogenesis (GO:0061333)3.11953266
83positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.11565666
84negative regulation of astrocyte differentiation (GO:0048712)3.10895547
85neurofilament cytoskeleton organization (GO:0060052)3.09884658
86prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.09738920
87exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07945192
88positive regulation of steroid hormone secretion (GO:2000833)3.07278302
89adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.06771648
90adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.06742938
91tooth mineralization (GO:0034505)14.3233920
92detection of chemical stimulus involved in sensory perception of smell (GO:0050911)13.6002321
93positive regulation of protein sumoylation (GO:0033235)11.9464964
94negative regulation of T-helper cell differentiation (GO:0045623)11.4265567
95negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)11.4265567
96protein K11-linked deubiquitination (GO:0035871)10.6466376
97regulation of T-helper 1 cell differentiation (GO:0045625)10.2661990
98regulation of T-helper 2 cell differentiation (GO:0045628)10.1264522
99negative regulation of type 2 immune response (GO:0002829)10.1088736
100activation of protein kinase A activity (GO:0034199)10.0847118

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.47452288
2EGR1_19374776_ChIP-ChIP_THP-1_Human5.58629906
3IGF1R_20145208_ChIP-Seq_DFB_Human4.77690861
4AR_21572438_ChIP-Seq_LNCaP_Human4.74530305
5VDR_22108803_ChIP-Seq_LS180_Human4.23539293
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.46646626
7TP53_16413492_ChIP-PET_HCT116_Human2.17195926
8PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.04474907
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse10.6437193
10TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90350004
11POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.90350004
12YY1_22570637_ChIP-Seq_MALME-3M_Human1.89833842
13ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.88880318
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.87645620
15GATA1_19941826_ChIP-Seq_K562_Human1.80078536
16NR3C1_23031785_ChIP-Seq_PC12_Mouse1.68818870
17DROSHA_22980978_ChIP-Seq_HELA_Human1.62312693
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59865176
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.56349441
20RNF2_27304074_Chip-Seq_ESCs_Mouse1.54895516
21EGR1_19032775_ChIP-ChIP_M12_Human1.53371867
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.51186669
23SMAD3_21741376_ChIP-Seq_HESCs_Human1.45700465
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44814123
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.43618510
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.43220479
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40686389
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.38027137
29SMAD3_21741376_ChIP-Seq_EPCs_Human1.35744110
30SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35479593
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34290357
32RNF2_27304074_Chip-Seq_NSC_Mouse1.25801999
33RXR_22108803_ChIP-Seq_LS180_Human1.25307561
34NANOG_18555785_Chip-Seq_ESCs_Mouse1.24980231
35TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.23061209
36CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20090354
37TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18408858
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16764368
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.12561903
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11913140
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11273087
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11087511
43GBX2_23144817_ChIP-Seq_PC3_Human1.09406000
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.07284137
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06544070
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06087027
47ER_23166858_ChIP-Seq_MCF-7_Human1.06070699
48HNFA_21074721_ChIP-Seq_CACO-2_Human1.05307051
49SOX2_18555785_Chip-Seq_ESCs_Mouse1.04964904
50SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04345188
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04242606
52EZH2_22144423_ChIP-Seq_EOC_Human1.04191238
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.03162882
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.01932919
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01326096
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.01184928
57DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00443737
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00351726
59PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99597181
60TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99284170
61GATA6_21074721_ChIP-Seq_CACO-2_Human0.98990083
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98029165
63KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97527281
64CMYC_18555785_Chip-Seq_ESCs_Mouse0.96991602
65VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96174491
66BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96168935
67SMAD4_21741376_ChIP-Seq_HESCs_Human0.95701043
68TBL1_22424771_ChIP-Seq_293T_Human0.95363224
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94508870
70CJUN_26792858_Chip-Seq_BT549_Human0.92927423
71STAT3_23295773_ChIP-Seq_U87_Human0.91738458
72PHF8_20622853_ChIP-Seq_HELA_Human0.90175051
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.90037351
74BCAT_22108803_ChIP-Seq_LS180_Human0.88547429
75GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.87732187
76TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87346390
77SUZ12_18555785_Chip-Seq_ESCs_Mouse0.86527323
78NANOG_16518401_ChIP-PET_MESCs_Mouse0.86055173
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85893458
80TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85635339
81E2F1_18555785_Chip-Seq_ESCs_Mouse0.83571921
82CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.83220804
83NMYC_18555785_Chip-Seq_ESCs_Mouse0.83067212
84CTCF_27219007_Chip-Seq_Bcells_Human0.83063703
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82566263
86ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82284018
87KLF4_18555785_Chip-Seq_ESCs_Mouse0.82217917
88PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.81884127
89EZH2_18974828_ChIP-Seq_MESCs_Mouse0.81736529
90RNF2_18974828_ChIP-Seq_MESCs_Mouse0.81736529
91REST_21632747_ChIP-Seq_MESCs_Mouse0.79418540
92EZH2_27294783_Chip-Seq_NPCs_Mouse0.79067456
93GATA2_19941826_ChIP-Seq_K562_Human0.76943146
94SMAD4_21799915_ChIP-Seq_A2780_Human0.76033758
95RING1B_27294783_Chip-Seq_ESCs_Mouse0.75629296
96P53_22387025_ChIP-Seq_ESCs_Mouse0.75478714
97CTBP2_25329375_ChIP-Seq_LNCAP_Human0.75251320
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74874028
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.74516394
100CBP_20019798_ChIP-Seq_JUKART_Human0.74498920

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism9.68554417
2MP0004130_abnormal_muscle_cell4.99415115
3MP0004264_abnormal_extraembryonic_tissu4.00417662
4MP0003252_abnormal_bile_duct3.65363432
5MP0004133_heterotaxia2.81516181
6MP0002928_abnormal_bile_duct2.75140981
7MP0006072_abnormal_retinal_apoptosis2.44378117
8MP0005448_abnormal_energy_balance2.30838721
9MP0005408_hypopigmentation2.28938786
10MP0002751_abnormal_autonomic_nervous2.24383302
11MP0003329_amyloid_beta_deposits2.13477837
12MP0001270_distended_abdomen2.11554181
13MP0004272_abnormal_basement_membrane2.08775817
14MP0005084_abnormal_gallbladder_morpholo12.6517028
15MP0005220_abnormal_exocrine_pancreas1.75986770
16MP0003943_abnormal_hepatobiliary_system1.75488917
17MP0005379_endocrine/exocrine_gland_phen1.72970506
18MP0005165_increased_susceptibility_to1.57578732
19MP0009764_decreased_sensitivity_to1.47865479
20MP0001958_emphysema1.43523118
21MP0000604_amyloidosis1.37681332
22MP0001529_abnormal_vocalization1.31084522
23MP0003718_maternal_effect1.20991694
24MP0005646_abnormal_pituitary_gland1.09183270
25MP0002909_abnormal_adrenal_gland1.04432797
26MP0000470_abnormal_stomach_morphology1.03709361
27MP0000465_gastrointestinal_hemorrhage1.03257428
28MP0001905_abnormal_dopamine_level1.00865098
29MP0001944_abnormal_pancreas_morphology1.00186727
30MP0002572_abnormal_emotion/affect_behav0.96598083
31MP0008569_lethality_at_weaning0.92131598
32MP0003638_abnormal_response/metabolism_0.91181125
33MP0000371_diluted_coat_color0.86151309
34MP0005164_abnormal_response_to0.82389632
35MP0001800_abnormal_humoral_immune0.80209034
36MP0008469_abnormal_protein_level0.80108486
37MP0003121_genomic_imprinting0.79942708
38MP0001915_intracranial_hemorrhage0.78733321
39MP0002405_respiratory_system_inflammati0.77501292
40MP0004019_abnormal_vitamin_homeostasis0.73365599
41MP0003866_abnormal_defecation0.72004449
42MP0002693_abnormal_pancreas_physiology0.70822419
43MP0000609_abnormal_liver_physiology0.70666604
44MP0002098_abnormal_vibrissa_morphology0.67023471
45MP0000703_abnormal_thymus_morphology0.66575814
46MP0008875_abnormal_xenobiotic_pharmacok0.65977810
47MP0005253_abnormal_eye_physiology0.65744128
48MP0005387_immune_system_phenotype0.64045166
49MP0001790_abnormal_immune_system0.64045166
50MP0002136_abnormal_kidney_physiology0.62870462
51MP0002078_abnormal_glucose_homeostasis0.62625741
52MP0001851_eye_inflammation0.62403394
53MP0001533_abnormal_skeleton_physiology0.61334755
54MP0003953_abnormal_hormone_level0.61105229
55MP0004947_skin_inflammation0.60579711
56MP0002822_catalepsy0.57983309
57MP0002998_abnormal_bone_remodeling0.56291764
58MP0001845_abnormal_inflammatory_respons0.51611580
59MP0003195_calcinosis0.49822889
60MP0002722_abnormal_immune_system0.47785878
61MP0009642_abnormal_blood_homeostasis0.46769530
62MP0005551_abnormal_eye_electrophysiolog0.42827890
63MP0002419_abnormal_innate_immunity0.41668724
64MP0005334_abnormal_fat_pad0.39033731
65MP0002429_abnormal_blood_cell0.38918520
66MP0004484_altered_response_of0.38617927
67MP0002452_abnormal_antigen_presenting0.37419491
68MP0000920_abnormal_myelination0.37137390
69MP0000759_abnormal_skeletal_muscle0.36040073
70MP0001835_abnormal_antigen_presentation0.35986543
71MP0000598_abnormal_liver_morphology0.35709634
72MP0002736_abnormal_nociception_after0.35363604
73MP0000477_abnormal_intestine_morphology0.34605398
74MP0001986_abnormal_taste_sensitivity0.34552757
75MP0002420_abnormal_adaptive_immunity0.33768480
76MP0000716_abnormal_immune_system0.33404226
77MP0005365_abnormal_bile_salt0.33185721
78MP0001819_abnormal_immune_cell0.33141075
79MP0005423_abnormal_somatic_nervous0.33031473
80MP0002882_abnormal_neuron_morphology0.32974516
81MP0009931_abnormal_skin_appearance0.32633954
82MP0001501_abnormal_sleep_pattern0.31787205
83MP0002229_neurodegeneration0.31466155
84MP0002398_abnormal_bone_marrow0.31344503
85MP0005390_skeleton_phenotype0.31299915
86MP0002723_abnormal_immune_serum0.31129815
87MP0008004_abnormal_stomach_pH0.30619017
88MP0002735_abnormal_chemical_nociception0.29331584
89MP0001299_abnormal_eye_distance/0.28997946
90MP0005000_abnormal_immune_tolerance0.28227883
91MP0005395_other_phenotype0.27053231
92MP0001175_abnormal_lung_morphology0.26788173
93MP0000689_abnormal_spleen_morphology0.26623660
94MP0002066_abnormal_motor_capabilities/c0.22014588
95MP0002128_abnormal_blood_circulation0.21270410
96MP0000858_altered_metastatic_potential0.21079542
97MP0003634_abnormal_glial_cell0.19935629
98MP0009053_abnormal_anal_canal0.19910380
99MP0003136_yellow_coat_color0.19848663
100MP0002396_abnormal_hematopoietic_system0.19825986

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of dental color (HP:0011073)8.29450235
2Abnormality of renal resorption (HP:0011038)8.11070266
3Osteomalacia (HP:0002749)7.91852325
4Polyuria (HP:0000103)7.61604967
5Abnormality of the dental pulp (HP:0006479)7.56766082
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.82924073
7Abnormal urine output (HP:0012590)6.52023058
8Abnormality of renal excretion (HP:0011036)5.70119491
9Round ear (HP:0100830)5.43718612
10Chronic bronchitis (HP:0004469)4.99624471
11IgM deficiency (HP:0002850)4.28391164
12Volvulus (HP:0002580)4.27795970
13Lip pit (HP:0100267)4.18531079
14Autoimmune thrombocytopenia (HP:0001973)4.04541861
15Toxemia of pregnancy (HP:0100603)4.02424822
16Esophageal varix (HP:0002040)3.88445772
17Nephrocalcinosis (HP:0000121)3.87591940
18Abnormality of midbrain morphology (HP:0002418)3.79731090
19Molar tooth sign on MRI (HP:0002419)3.79731090
20Lipoatrophy (HP:0100578)3.40857740
21Abnormal respiratory motile cilium physiology (HP:0012261)3.36428672
22Depressed nasal tip (HP:0000437)3.33809705
23Sparse lateral eyebrow (HP:0005338)3.32535583
24Large earlobe (HP:0009748)3.30921168
25Rhinitis (HP:0012384)3.27150897
26Drooling (HP:0002307)3.22784624
27Tachypnea (HP:0002789)3.21899205
28Panhypogammaglobulinemia (HP:0003139)3.10357403
29Excessive salivation (HP:0003781)3.09898197
30Hypoparathyroidism (HP:0000829)3.09601400
31Intestinal fistula (HP:0100819)3.05582913
32Hyperphosphaturia (HP:0003109)2.87308912
33Personality changes (HP:0000751)2.85145773
34Thick eyebrow (HP:0000574)2.83802226
35Petechiae (HP:0000967)2.68378423
36Nephronophthisis (HP:0000090)2.63325125
37Ureteral stenosis (HP:0000071)2.56576054
38Hepatitis (HP:0012115)2.56447345
39Dilated cardiomyopathy (HP:0001644)2.53854993
40Chronic mucocutaneous candidiasis (HP:0002728)2.48752481
41Recurrent cutaneous fungal infections (HP:0011370)2.48752481
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.47711045
43Abnormality of the fingertips (HP:0001211)2.45090292
44Abnormal urine phosphate concentration (HP:0012599)2.42229534
45Short 5th finger (HP:0009237)2.41232803
46Ureteral obstruction (HP:0006000)2.39206104
47Striae distensae (HP:0001065)2.32190162
48Abnormality of transition element cation homeostasis (HP:0011030)2.30488324
49Colitis (HP:0002583)2.30456588
50Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.30401341
51Gingival overgrowth (HP:0000212)2.30278535
52Glycosuria (HP:0003076)2.29696361
53Abnormality of urine glucose concentration (HP:0011016)2.29696361
54Sudden cardiac death (HP:0001645)2.28500654
55Nephropathy (HP:0000112)2.26778697
56Bronchitis (HP:0012387)2.23699977
57Hypercalciuria (HP:0002150)2.18055844
58Inability to walk (HP:0002540)2.15094144
59Recurrent otitis media (HP:0000403)2.15070455
60Agammaglobulinemia (HP:0004432)2.14419402
61Periauricular skin pits (HP:0100277)2.11990483
62Preauricular pit (HP:0004467)2.11990483
63Decreased muscle mass (HP:0003199)2.10008193
64Abnormality of salivation (HP:0100755)2.05438754
65Overgrowth (HP:0001548)12.3019262
66Amelogenesis imperfecta (HP:0000705)11.6766786
67Abnormality of calcium-phosphate metabolism (HP:0100530)10.0948279
68Chondrocalcinosis (HP:0000934)1.99160448
69Abnormality of the renal medulla (HP:0100957)1.97576630
70Delayed eruption of teeth (HP:0000684)1.96950724
71Anal stenosis (HP:0002025)1.96344525
72Abnormality of Sharpey fibers (HP:0100685)1.94880232
73Truncal ataxia (HP:0002078)1.88328227
74Chorioretinal coloboma (HP:0000567)1.87585134
75Ectopic kidney (HP:0000086)1.83871482
76Preauricular skin tag (HP:0000384)1.79485548
77Prominent supraorbital ridges (HP:0000336)1.78399419
78Renal tubular dysfunction (HP:0000124)1.77548041
79Stage 5 chronic kidney disease (HP:0003774)1.74504049
80Limited elbow extension (HP:0001377)1.71480292
81Villous atrophy (HP:0011473)1.69172834
82Abnormality of small intestinal villus morphology (HP:0011472)1.69172834
83Torticollis (HP:0000473)1.61492322
84Small hand (HP:0200055)1.57713556
85Ectropion (HP:0000656)1.57661469
86Polyneuropathy (HP:0001271)1.57214472
87Oculomotor apraxia (HP:0000657)1.56625320
88Palmoplantar keratoderma (HP:0000982)1.56395908
89Bronchiectasis (HP:0002110)1.54066992
90Skin tags (HP:0010609)1.51252838
91Blepharitis (HP:0000498)1.50229928
92Viral hepatitis (HP:0006562)1.49694769
93Mask-like facies (HP:0000298)1.48910861
94Prenatal maternal abnormality (HP:0002686)1.48584981
95Inflammation of the large intestine (HP:0002037)1.44410318
96Skin pits (HP:0100276)1.42924848
97Highly arched eyebrow (HP:0002553)1.39452710
98Proximal placement of thumb (HP:0009623)1.37807733
99Osteoarthritis (HP:0002758)1.35463608
100Gastrointestinal inflammation (HP:0004386)1.31012912

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.65557564
2BLK4.51429008
3STK34.08551899
4RIPK43.20196209
5CDC42BPA2.15566864
6BMPR22.11630462
7NTRK214.1751333
8HIPK21.25671423
9FGFR10.92338527
10ROCK20.78212865
11SYK0.71387845
12SRC0.63230401
13INSRR0.62151723
14OBSCN0.60938132
15PRKCQ0.59765548
16PRKAA10.56356679
17MUSK0.55137286
18ROCK10.53647186
19GRK70.52173920
20MAP4K20.50082999
21TXK0.47753802
22WNK30.46237165
23PRKACG0.44122776
24TIE10.42985400
25ABL10.42654931
26ADRBK20.41432808
27GRK10.41170206
28MAPK150.40592036
29PIK3CG0.39435750
30PRKACA0.36344120
31PRKACB0.35228747
32SRPK10.32458761
33ERBB40.32319087
34CAMK2A0.32137758
35LYN0.27914945
36MATK0.26841682
37PLK10.23976521
38GRK50.23081055
39EPHA40.22037524
40PRKCA0.21963524
41MAPK140.21495895
42KIT0.20842155
43GSK3B0.20646908
44TEC0.19850696
45PRKCB0.19742986
46RPS6KA30.19169093
47MST1R0.19047949
48KDR0.18711453
49PLK40.18648098
50FYN0.18410009
51TLK10.18097473
52LMTK20.17753838
53TTN0.17668358
54DDR20.17530411
55GRK60.16898024
56ITK0.15915180
57CSNK1A10.14820904
58PHKG10.14632562
59PHKG20.14632562
60CHUK0.13693037
61CDK10.12991878
62EPHA20.12910738
63PRKCD0.12496146
64PIM20.12266320
65MAP2K60.12214890
66ADRBK10.10703897
67LCK0.10538132
68OXSR10.10385453
69BTK0.10091618
70TGFBR20.09598440
71HCK0.09465129
72IKBKE0.09424401
73TNK20.09180915
74MAPK90.09123600
75PRKDC0.09035558
76WNK40.08758698
77TAOK20.08626234
78FRK0.08168975
79EGFR0.08081241
80IGF1R0.08037693
81MAP3K30.07865700
82PKN10.07731650
83PIM10.07518401
84PRKCG0.06880379
85CAMK2G0.06835345
86AKT10.05878044
87PIK3CA0.05107115
88MOS0.04398097
89INSR0.03832308
90SGK10.03683046
91PRKCE0.03387086
92PRKG10.03277656
93CSK0.02981588
94ABL20.02786175
95PINK10.02283888
96MAP2K70.02145293
97CAMK2B0.02042658
98ZAK0.01847966
99IRAK40.01634157
100STK390.01605060

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.26295722
2Sulfur relay system_Homo sapiens_hsa041223.70586243
3Sulfur metabolism_Homo sapiens_hsa009203.64665099
4Ovarian steroidogenesis_Homo sapiens_hsa049133.35883834
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.15779910
6Linoleic acid metabolism_Homo sapiens_hsa005912.89075617
7Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.87444053
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.74271507
9Collecting duct acid secretion_Homo sapiens_hsa049662.50193571
10Vibrio cholerae infection_Homo sapiens_hsa051102.37944229
11Bile secretion_Homo sapiens_hsa049762.36709331
12Thyroid hormone synthesis_Homo sapiens_hsa049182.21329725
13Pancreatic secretion_Homo sapiens_hsa049722.20286105
14Salivary secretion_Homo sapiens_hsa049702.13068438
15Gastric acid secretion_Homo sapiens_hsa049712.09564806
16Fat digestion and absorption_Homo sapiens_hsa049752.08973710
17Synaptic vesicle cycle_Homo sapiens_hsa047212.03390386
18Cocaine addiction_Homo sapiens_hsa050301.95390898
19Circadian entrainment_Homo sapiens_hsa047131.84580173
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.82287815
21Insulin secretion_Homo sapiens_hsa049111.78408306
22Taste transduction_Homo sapiens_hsa047421.75599409
23Vascular smooth muscle contraction_Homo sapiens_hsa042701.74981494
24Glutamatergic synapse_Homo sapiens_hsa047241.73486666
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.72864838
26GABAergic synapse_Homo sapiens_hsa047271.70399882
27Morphine addiction_Homo sapiens_hsa050321.69973843
28Dilated cardiomyopathy_Homo sapiens_hsa054141.66409847
29Longevity regulating pathway - mammal_Homo sapiens_hsa042111.63197611
30Ether lipid metabolism_Homo sapiens_hsa005651.61217292
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56695568
32Gap junction_Homo sapiens_hsa045401.55404248
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46200627
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.44813923
35Amphetamine addiction_Homo sapiens_hsa050311.42458918
36GnRH signaling pathway_Homo sapiens_hsa049121.39174411
37Arachidonic acid metabolism_Homo sapiens_hsa005901.33322949
38Melanogenesis_Homo sapiens_hsa049161.33214624
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25733755
40Oxytocin signaling pathway_Homo sapiens_hsa049211.16763069
41Platelet activation_Homo sapiens_hsa046111.16625275
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14522000
43Cholinergic synapse_Homo sapiens_hsa047251.14186592
44Estrogen signaling pathway_Homo sapiens_hsa049151.07864300
45Calcium signaling pathway_Homo sapiens_hsa040201.05527285
46Circadian rhythm_Homo sapiens_hsa047100.98861836
47Dorso-ventral axis formation_Homo sapiens_hsa043200.90274338
48Pyruvate metabolism_Homo sapiens_hsa006200.80329612
49Serotonergic synapse_Homo sapiens_hsa047260.77889138
50Oocyte meiosis_Homo sapiens_hsa041140.73642549
51Chemokine signaling pathway_Homo sapiens_hsa040620.73065097
52ECM-receptor interaction_Homo sapiens_hsa045120.72241770
53Rheumatoid arthritis_Homo sapiens_hsa053230.69370174
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64445455
55RNA degradation_Homo sapiens_hsa030180.53122370
56cAMP signaling pathway_Homo sapiens_hsa040240.47436158
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47218875
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.42081227
59Alcoholism_Homo sapiens_hsa050340.40079011
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38586893
61Primary immunodeficiency_Homo sapiens_hsa053400.36591207
62Staphylococcus aureus infection_Homo sapiens_hsa051500.35231278
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34301670
64Dopaminergic synapse_Homo sapiens_hsa047280.33987169
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.33813176
66Parkinsons disease_Homo sapiens_hsa050120.32714509
67Prion diseases_Homo sapiens_hsa050200.28099573
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.26352077
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.25494093
70Rap1 signaling pathway_Homo sapiens_hsa040150.23353160
71Purine metabolism_Homo sapiens_hsa002300.21411479
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.19965356
73Hedgehog signaling pathway_Homo sapiens_hsa043400.19827518
74Retinol metabolism_Homo sapiens_hsa008300.18751870
75Tuberculosis_Homo sapiens_hsa051520.17499862
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.16577519
77Phagosome_Homo sapiens_hsa041450.16476345
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.16352833
79Oxidative phosphorylation_Homo sapiens_hsa001900.14523938
80Glucagon signaling pathway_Homo sapiens_hsa049220.14109998
81Systemic lupus erythematosus_Homo sapiens_hsa053220.13500496
82Leishmaniasis_Homo sapiens_hsa051400.13263725
83Type I diabetes mellitus_Homo sapiens_hsa049400.12544987
84Ras signaling pathway_Homo sapiens_hsa040140.11489178
85Caffeine metabolism_Homo sapiens_hsa002320.11179979
86HTLV-I infection_Homo sapiens_hsa051660.10527637
87African trypanosomiasis_Homo sapiens_hsa051430.10171606
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.09368364
89Nicotine addiction_Homo sapiens_hsa050330.08536818
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.08055758
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.06733083
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.06034904
93Hematopoietic cell lineage_Homo sapiens_hsa046400.05431261
94Renin secretion_Homo sapiens_hsa049240.05426045
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.04756990
96Chemical carcinogenesis_Homo sapiens_hsa052040.04244287
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.04103602
98Asthma_Homo sapiens_hsa053100.02319082
99Amoebiasis_Homo sapiens_hsa051460.00925227
100Graft-versus-host disease_Homo sapiens_hsa05332-0.0096825

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