OR11K1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)9.25127198
2spermatid development (GO:0007286)8.77900996
3chromosome condensation (GO:0030261)8.46585757
4DNA packaging (GO:0006323)8.35137044
5plasma membrane fusion (GO:0045026)8.20240775
6microtubule depolymerization (GO:0007019)8.15677199
7single strand break repair (GO:0000012)7.70831028
8protein polyglutamylation (GO:0018095)7.65936620
9sperm-egg recognition (GO:0035036)7.56743255
10multicellular organism reproduction (GO:0032504)7.56027090
11spermatid nucleus differentiation (GO:0007289)7.37789417
12protein targeting to Golgi (GO:0000042)7.20048053
13phosphatidylethanolamine biosynthetic process (GO:0006646)7.09482960
14rRNA methylation (GO:0031167)7.04664429
15establishment of protein localization to Golgi (GO:0072600)6.95323816
16reproduction (GO:0000003)6.85584056
17microtubule polymerization or depolymerization (GO:0031109)6.72367572
18negative regulation of inclusion body assembly (GO:0090084)6.72242891
19retrograde transport, vesicle recycling within Golgi (GO:0000301)6.71746380
20binding of sperm to zona pellucida (GO:0007339)6.68890171
21phosphatidylethanolamine metabolic process (GO:0046337)6.65353430
22response to pheromone (GO:0019236)6.49567715
23axonemal dynein complex assembly (GO:0070286)6.46997279
24calcium ion-dependent exocytosis (GO:0017156)6.45059881
25microtubule severing (GO:0051013)6.44028801
26cell-cell recognition (GO:0009988)6.23387085
27spermatogenesis (GO:0007283)6.22253118
28male gamete generation (GO:0048232)6.20177688
29regulation of cilium movement (GO:0003352)6.07999049
30rRNA modification (GO:0000154)5.93945670
31sexual reproduction (GO:0019953)5.90196897
32cellular ketone body metabolic process (GO:0046950)5.86110866
33cell wall macromolecule catabolic process (GO:0016998)5.83609531
34gamete generation (GO:0007276)5.69172060
35centriole replication (GO:0007099)5.51370771
36cell wall macromolecule metabolic process (GO:0044036)5.45256902
37single fertilization (GO:0007338)5.26800174
38cilium or flagellum-dependent cell motility (GO:0001539)5.25498220
39RNA destabilization (GO:0050779)5.18879995
40ketone body metabolic process (GO:1902224)5.17002815
41protein localization to Golgi apparatus (GO:0034067)5.15248426
42centriole assembly (GO:0098534)4.97502283
43germ cell development (GO:0007281)4.89858174
44positive regulation of Rab GTPase activity (GO:0032851)4.87622897
45regulation of Rab GTPase activity (GO:0032313)4.87622897
46motile cilium assembly (GO:0044458)4.86569790
47regulation of inclusion body assembly (GO:0090083)4.78350415
48epithelial cilium movement (GO:0003351)4.74529754
49cellular process involved in reproduction in multicellular organism (GO:0022412)4.58613542
50multicellular organismal reproductive process (GO:0048609)4.57782386
51regulation of centriole replication (GO:0046599)4.56447801
52regulation of transcription involved in cell fate commitment (GO:0060850)4.52952106
53seminiferous tubule development (GO:0072520)4.48310139
54fertilization (GO:0009566)4.43990412
55regulation of microtubule-based movement (GO:0060632)4.31789613
56organic cation transport (GO:0015695)4.23916597
57cilium movement (GO:0003341)4.13546417
58nucleus organization (GO:0006997)4.08390314
59multicellular organismal movement (GO:0050879)3.91354289
60musculoskeletal movement (GO:0050881)3.91354289
61response to acidic pH (GO:0010447)3.71771966
62polyamine biosynthetic process (GO:0006596)3.68533926
63membrane protein intracellular domain proteolysis (GO:0031293)3.68433718
64chromatin silencing (GO:0006342)3.66042266
65microtubule nucleation (GO:0007020)3.55872905
66cellular response to pH (GO:0071467)3.38010271
67peptidyl-threonine dephosphorylation (GO:0035970)3.36847896
68nucleosome disassembly (GO:0006337)3.34845578
69protein-DNA complex disassembly (GO:0032986)3.34845578
70regulation of phosphoprotein phosphatase activity (GO:0043666)3.29212897
71coenzyme catabolic process (GO:0009109)3.25133088
72Golgi to endosome transport (GO:0006895)3.22872014
73multicellular organismal development (GO:0007275)3.19619157
74detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.18249609
75cerebral cortex neuron differentiation (GO:0021895)3.16777405
76homeostasis of number of cells within a tissue (GO:0048873)3.08780519
77glomerular visceral epithelial cell development (GO:0072015)3.06221004
78cell recognition (GO:0008037)3.04784644
79negative regulation of Rho protein signal transduction (GO:0035024)3.04530130
80protein depolymerization (GO:0051261)2.98848150
81glycerol ether metabolic process (GO:0006662)2.97838598
82ventricular system development (GO:0021591)2.97377959
83regulation of interleukin-13 production (GO:0032656)2.97141677
84glomerular epithelial cell development (GO:0072310)2.95183884
85regulation of T-helper 2 cell differentiation (GO:0045628)2.95166632
86positive regulation of endothelial cell differentiation (GO:0045603)2.89424401
87epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.88656216
88cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.86359114
89male meiosis (GO:0007140)2.86350668
90intra-Golgi vesicle-mediated transport (GO:0006891)2.85257947
91positive regulation of guanylate cyclase activity (GO:0031284)2.80993381
92centrosome duplication (GO:0051298)2.80889899
93peptidyl-glutamic acid modification (GO:0018200)2.76342367
94ether metabolic process (GO:0018904)2.74070349
95mitochondrial fission (GO:0000266)2.72635778
96histone H3-K9 demethylation (GO:0033169)2.70355067
97DNA conformation change (GO:0071103)2.69456019
98sperm motility (GO:0030317)12.4421162
99acrosome reaction (GO:0007340)11.9097444
100fusion of sperm to egg plasma membrane (GO:0007342)10.8193818

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.88426654
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.45306399
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.17958420
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.73329726
5EZH2_22144423_ChIP-Seq_EOC_Human2.47402699
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.43957933
7TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42736740
8POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.42736740
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.35219276
10IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.32778925
11CBP_20019798_ChIP-Seq_JUKART_Human2.32778925
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.23713828
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.11471394
14FUS_26573619_Chip-Seq_HEK293_Human2.00585790
15BP1_19119308_ChIP-ChIP_Hs578T_Human1.97923050
16DROSHA_22980978_ChIP-Seq_HELA_Human1.92595902
17RAC3_21632823_ChIP-Seq_H3396_Human1.83022585
18ELF1_20517297_ChIP-Seq_JURKAT_Human1.82352118
19EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.76428116
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.75249541
21NANOG_20526341_ChIP-Seq_ESCs_Human1.73853330
22RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.71749753
23ERA_21632823_ChIP-Seq_H3396_Human1.70746746
24UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70199544
25CTCF_27219007_Chip-Seq_Bcells_Human1.66197857
26VDR_22108803_ChIP-Seq_LS180_Human1.65511541
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63764179
28ER_23166858_ChIP-Seq_MCF-7_Human1.62798262
29ARNT_22903824_ChIP-Seq_MCF-7_Human1.62401381
30WDR5_24793694_ChIP-Seq_LNCAP_Human1.62299854
31EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.58585320
32SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56882327
33AR_25329375_ChIP-Seq_VCAP_Human1.55975848
34SMAD4_21741376_ChIP-Seq_EPCs_Human1.55162053
35TAF2_19829295_ChIP-Seq_ESCs_Human1.51153662
36OCT4_20526341_ChIP-Seq_ESCs_Human1.50748407
37EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.48743611
38MYC_19829295_ChIP-Seq_ESCs_Human1.48102242
39BCL6_27268052_Chip-Seq_Bcells_Human1.46878707
40SMC4_20622854_ChIP-Seq_HELA_Human1.45111502
41PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.44746527
42AUTS2_25519132_ChIP-Seq_293T-REX_Human1.41728024
43TP53_18474530_ChIP-ChIP_U2OS_Human1.41664922
44CBX2_22325352_ChIP-Seq_293T-Rex_Human1.41402324
45ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41083866
46E2F1_20622854_ChIP-Seq_HELA_Human1.40819624
47RBPJ_21746931_ChIP-Seq_IB4_Human1.40627008
48YY1_22570637_ChIP-Seq_MALME-3M_Human1.39545215
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.39159066
50CTCF_20526341_ChIP-Seq_ESCs_Human1.38943197
51HNFA_21074721_ChIP-Seq_CACO-2_Human1.38679114
52TDRD3_21172665_ChIP-Seq_MCF-7_Human1.36598701
53CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.36547915
54PHF8_20622854_ChIP-Seq_HELA_Human1.35124210
55BCOR_27268052_Chip-Seq_Bcells_Human1.34913848
56ETV1_20927104_ChIP-Seq_GIST48_Human1.33234631
57SMAD3_21741376_ChIP-Seq_ESCs_Human1.33193661
58P68_20966046_ChIP-Seq_HELA_Human1.33016340
59ERG_20517297_ChIP-Seq_VCAP_Human1.32866352
60P300_19829295_ChIP-Seq_ESCs_Human1.31453729
61SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31408469
62TP63_22573176_ChIP-Seq_HFKS_Human1.31280951
63AR_21572438_ChIP-Seq_LNCaP_Human1.28661984
64ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28551451
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28527553
66NFYB_21822215_ChIP-Seq_K562_Human1.26742840
67TBL1_22424771_ChIP-Seq_293T_Human1.26689567
68SMAD4_21799915_ChIP-Seq_A2780_Human1.23933571
69P300_27268052_Chip-Seq_Bcells_Human1.23871894
70PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.22386951
71CEBPB_22108803_ChIP-Seq_LS180_Human1.22119975
72TAF15_26573619_Chip-Seq_HEK293_Human1.20229121
73P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.20157905
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.18777753
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18263586
76SOX2_19829295_ChIP-Seq_ESCs_Human1.17792686
77NANOG_19829295_ChIP-Seq_ESCs_Human1.17792686
78PHF8_20622853_ChIP-Seq_HELA_Human1.17297667
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17152206
80STAT3_23295773_ChIP-Seq_U87_Human1.15430912
81SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12087560
82SMAD4_21741376_ChIP-Seq_HESCs_Human1.11800294
83GATA6_21074721_ChIP-Seq_CACO-2_Human1.11661332
84KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.11228836
85ZNF274_21170338_ChIP-Seq_K562_Hela1.10848328
86OCT1_27270436_Chip-Seq_PROSTATE_Human1.10567219
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10444663
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10277023
89PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.10219367
90SMRT_27268052_Chip-Seq_Bcells_Human1.09912729
91SOX2_22085726_ChIP-Seq_NPCs_Mouse1.09901643
92P53_21459846_ChIP-Seq_SAOS-2_Human1.09345520
93RUNX2_22187159_ChIP-Seq_PCA_Human1.08993779
94NFYA_21822215_ChIP-Seq_K562_Human1.08955213
95LXR_22292898_ChIP-Seq_THP-1_Human1.08532457
96SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07609951
97RUNX1_26923725_Chip-Seq_HPCs_Mouse1.05351180
98GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03281394
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99818026
100GBX2_23144817_ChIP-Seq_PC3_Human0.99616686

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology4.92669782
2MP0005377_hearing/vestibular/ear_phenot4.92669782
3MP0005670_abnormal_white_adipose4.92140318
4MP0003698_abnormal_male_reproductive4.63313950
5MP0001929_abnormal_gametogenesis4.09783182
6MP0002161_abnormal_fertility/fecundity2.58299586
7MP0001348_abnormal_lacrimal_gland2.54976015
8MP0003646_muscle_fatigue2.42160979
9MP0003718_maternal_effect2.18374480
10MP0005410_abnormal_fertilization12.4378260
11MP0005423_abnormal_somatic_nervous1.96846659
12MP0002210_abnormal_sex_determination1.95625296
13MP0000678_abnormal_parathyroid_gland1.86263347
14MP0001485_abnormal_pinna_reflex1.69923147
15MP0009053_abnormal_anal_canal1.68393122
16MP0001486_abnormal_startle_reflex1.64578540
17MP0001145_abnormal_male_reproductive1.60654023
18MP0000653_abnormal_sex_gland1.52723335
19MP0002132_abnormal_respiratory_system1.50052991
20MP0005379_endocrine/exocrine_gland_phen1.44285970
21MP0002822_catalepsy1.43858497
22MP0002735_abnormal_chemical_nociception1.41276329
23MP0005310_abnormal_salivary_gland1.38200561
24MP0003879_abnormal_hair_cell1.38192077
25MP0003011_delayed_dark_adaptation1.32845789
26MP0002234_abnormal_pharynx_morphology1.32772499
27MP0001765_abnormal_ion_homeostasis1.32152403
28MP0004859_abnormal_synaptic_plasticity1.26846585
29MP0001968_abnormal_touch/_nociception1.26452078
30MP0004742_abnormal_vestibular_system1.23140284
31MP0005451_abnormal_body_composition1.22991030
32MP0001963_abnormal_hearing_physiology1.18966109
33MP0002138_abnormal_hepatobiliary_system1.15646226
34MP0002282_abnormal_trachea_morphology1.12004693
35MP0002249_abnormal_larynx_morphology1.10294258
36MP0005551_abnormal_eye_electrophysiolog1.05760014
37MP0000534_abnormal_ureter_morphology1.01115416
38MP0001501_abnormal_sleep_pattern1.00644227
39MP0005248_abnormal_Harderian_gland1.00621253
40MP0009115_abnormal_fat_cell0.98124475
41MP0005395_other_phenotype0.94951330
42MP0000955_abnormal_spinal_cord0.94113752
43MP0000026_abnormal_inner_ear0.94014115
44MP0005253_abnormal_eye_physiology0.90750353
45MP0002229_neurodegeneration0.89382988
46MP0001905_abnormal_dopamine_level0.87749563
47MP0005167_abnormal_blood-brain_barrier0.87067104
48MP0002067_abnormal_sensory_capabilities0.84434403
49MP0002272_abnormal_nervous_system0.84323641
50MP0005408_hypopigmentation0.81421990
51MP0002557_abnormal_social/conspecific_i0.80562467
52MP0008569_lethality_at_weaning0.78740430
53MP0004510_myositis0.77116155
54MP0002127_abnormal_cardiovascular_syste0.77105531
55MP0003880_abnormal_central_pattern0.76629303
56MP0002733_abnormal_thermal_nociception0.76430454
57MP0008877_abnormal_DNA_methylation0.76355497
58MP0009745_abnormal_behavioral_response0.71756572
59MP0002653_abnormal_ependyma_morphology0.66983349
60MP0005666_abnormal_adipose_tissue0.66692066
61MP0004085_abnormal_heartbeat0.66240093
62MP0001440_abnormal_grooming_behavior0.65936838
63MP0002572_abnormal_emotion/affect_behav0.65377807
64MP0004233_abnormal_muscle_weight0.63296263
65MP0005636_abnormal_mineral_homeostasis0.60766902
66MP0008995_early_reproductive_senescence0.60483838
67MP0004019_abnormal_vitamin_homeostasis0.59052788
68MP0001986_abnormal_taste_sensitivity0.59045994
69MP0001984_abnormal_olfaction0.58014342
70MP0001970_abnormal_pain_threshold0.56958039
71MP0009697_abnormal_copulation0.56704524
72MP0000681_abnormal_thyroid_gland0.56152653
73MP0000049_abnormal_middle_ear0.55666422
74MP0003631_nervous_system_phenotype0.54474792
75MP0005083_abnormal_biliary_tract0.54442440
76MP0001879_abnormal_lymphatic_vessel0.53572820
77MP0003119_abnormal_digestive_system0.51984901
78MP0005375_adipose_tissue_phenotype0.49828057
79MP0004484_altered_response_of0.49026644
80MP0004036_abnormal_muscle_relaxation0.48550883
81MP0003635_abnormal_synaptic_transmissio0.47763272
82MP0000613_abnormal_salivary_gland0.46870089
83MP0003632_abnormal_nervous_system0.46386686
84MP0005647_abnormal_sex_gland0.44968390
85MP0000516_abnormal_urinary_system0.44575164
86MP0005367_renal/urinary_system_phenotyp0.44575164
87MP0002736_abnormal_nociception_after0.43835041
88MP0009046_muscle_twitch0.43788573
89MP0003633_abnormal_nervous_system0.41959344
90MP0002928_abnormal_bile_duct0.41587556
91MP0003077_abnormal_cell_cycle0.41462519
92MP0003699_abnormal_female_reproductive0.40827048
93MP0000230_abnormal_systemic_arterial0.40553535
94MP0001666_abnormal_nutrient_absorption0.40301297
95MP0010329_abnormal_lipoprotein_level0.40057283
96MP0006276_abnormal_autonomic_nervous0.39499864
97MP0000470_abnormal_stomach_morphology0.39049878
98MP0003936_abnormal_reproductive_system0.38247374
99MP0002734_abnormal_mechanical_nocicepti0.37880712
100MP0005391_vision/eye_phenotype0.37747960

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.95274266
2Absent/shortened dynein arms (HP:0200106)6.17420783
3Dynein arm defect of respiratory motile cilia (HP:0012255)6.17420783
4Tubulointerstitial nephritis (HP:0001970)5.82748598
5Chronic hepatic failure (HP:0100626)5.51457530
6Attenuation of retinal blood vessels (HP:0007843)5.22859252
7Resting tremor (HP:0002322)5.15801468
8Bony spicule pigmentary retinopathy (HP:0007737)5.14558574
9Asymmetric septal hypertrophy (HP:0001670)4.93663591
10Abnormal respiratory motile cilium physiology (HP:0012261)4.83582023
11Hyperkalemia (HP:0002153)4.80183803
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.76816957
13Abnormal ciliary motility (HP:0012262)4.73368638
14Abnormality of macular pigmentation (HP:0008002)4.49226111
15Abnormal respiratory motile cilium morphology (HP:0005938)4.48720423
16Abnormal respiratory epithelium morphology (HP:0012253)4.48720423
17Infertility (HP:0000789)4.38434048
18Male infertility (HP:0003251)4.22124553
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.16246778
20Cone-rod dystrophy (HP:0000548)4.08729209
21Bell-shaped thorax (HP:0001591)4.02496494
22Nasal polyposis (HP:0100582)4.02347926
23Abnormal rod and cone electroretinograms (HP:0008323)3.97475513
24Facial shape deformation (HP:0011334)3.70713118
25Potter facies (HP:0002009)3.70713118
26Hypoplasia of the thymus (HP:0000778)3.61082517
27Postural instability (HP:0002172)3.54693499
28Hypoalphalipoproteinemia (HP:0003233)3.45159935
29Hypoplastic ischia (HP:0003175)3.43749488
30Aplasia/Hypoplasia of the earlobes (HP:0009906)3.40574810
31Impulsivity (HP:0100710)3.40024991
32Menstrual irregularities (HP:0000858)3.26892503
33Progressive sensorineural hearing impairment (HP:0000408)3.25310391
34Abnormality of the nasal mucosa (HP:0000433)3.24618492
35Abnormal spermatogenesis (HP:0008669)3.16396790
36Renovascular hypertension (HP:0100817)3.11072301
37Abnormality of the ischium (HP:0003174)3.10331741
38Rhinitis (HP:0012384)3.06751175
39Enlarged epiphyses (HP:0010580)3.03489607
40Azoospermia (HP:0000027)3.03448649
41Truncal obesity (HP:0001956)2.92949939
42Amelogenesis imperfecta (HP:0000705)2.84163154
43Progressive cerebellar ataxia (HP:0002073)2.83943514
44Portal hypertension (HP:0001409)2.82178739
45Tubulointerstitial abnormality (HP:0001969)2.76844148
46Insulin-resistant diabetes mellitus (HP:0000831)2.74918442
47Abnormal urine output (HP:0012590)2.68351171
48Nephronophthisis (HP:0000090)2.67228749
49Abnormality of potassium homeostasis (HP:0011042)2.59692373
50Abnormality of the hepatic vasculature (HP:0006707)2.59660185
51Generalized aminoaciduria (HP:0002909)2.53759737
52Abnormality of dental color (HP:0011073)2.53261562
53Stage 5 chronic kidney disease (HP:0003774)2.46658384
54Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.43439300
55Chronic bronchitis (HP:0004469)2.43218621
56Polydipsia (HP:0001959)2.42764179
57Abnormal drinking behavior (HP:0030082)2.42764179
58Renal dysplasia (HP:0000110)2.36757463
59Unilateral renal agenesis (HP:0000122)2.31471023
60Abnormality of renal excretion (HP:0011036)2.30261089
61Abnormality of the renal medulla (HP:0100957)2.29134479
62Hyperuricemia (HP:0002149)2.28327808
63Increased purine levels (HP:0004368)2.28327808
64Abnormality of the aortic arch (HP:0012303)2.22530056
65Pendular nystagmus (HP:0012043)2.19559165
66Abnormality of the costochondral junction (HP:0000919)2.17744563
67Ventricular tachycardia (HP:0004756)2.15502934
68Congenital malformation of the right heart (HP:0011723)2.14418064
69Double outlet right ventricle (HP:0001719)2.14418064
70Polyuria (HP:0000103)2.14405254
71Bronchiectasis (HP:0002110)2.14252726
72Epiphyseal dysplasia (HP:0002656)2.12900746
73Decreased central vision (HP:0007663)2.09349688
74Progressive hearing impairment (HP:0001730)2.08943404
75Recurrent pneumonia (HP:0006532)2.08423914
76Congenital sensorineural hearing impairment (HP:0008527)2.04015621
77Myokymia (HP:0002411)2.03435195
78Flattened epiphyses (HP:0003071)2.02159474
79Abnormality of the parathyroid morphology (HP:0011766)1.96793977
80Horizontal nystagmus (HP:0000666)1.95612965
81Optic nerve hypoplasia (HP:0000609)1.95163182
82Osteomalacia (HP:0002749)1.94494834
83Subcapsular cataract (HP:0000523)1.93579160
84Hypophosphatemic rickets (HP:0004912)1.90123903
85Widely patent fontanelles and sutures (HP:0004492)1.87472532
86Photophobia (HP:0000613)1.86317599
87Neoplasm of the heart (HP:0100544)1.85222400
88Bradycardia (HP:0001662)1.84459545
89Hypolipoproteinemia (HP:0010981)1.79626169
90Occipital encephalocele (HP:0002085)1.78350416
91Insulin resistance (HP:0000855)1.77689903
92Abnormality of chloride homeostasis (HP:0011422)1.75827833
93Abnormality of the epiphysis of the femoral head (HP:0010574)1.72521692
94Hyponatremia (HP:0002902)1.67099556
95Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.66527186
96Absent epiphyses (HP:0010577)1.66527186
97Tetany (HP:0001281)1.66093636
98Recurrent corneal erosions (HP:0000495)1.63270773
99Accelerated skeletal maturation (HP:0005616)1.62282623
100Intellectual disability, moderate (HP:0002342)1.61702499

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.93317309
2TESK15.13371418
3DDR24.09994478
4STK384.08425457
5STK38L3.55855650
6INSRR3.30985646
7BRD43.30865212
8PNCK3.24368900
9PLK23.11678114
10PRKD33.03207862
11MAP4K22.62413816
12CAMK1G2.34112594
13NEK62.25518280
14MAPK152.23747187
15FRK2.10451376
16PIK3CG1.90136438
17MST1R1.87463348
18PDPK11.64045489
19PDK11.55556840
20MAP3K91.46638326
21PDK21.34991982
22PINK11.27510341
23DYRK1B1.22050174
24CDK121.18200799
25WNK11.16469253
26PTK2B1.14864987
27AKT31.05828846
28CDK70.96554630
29SIK20.95252711
30TYRO30.91501982
31MAP2K20.90235098
32RPS6KA20.75608428
33CAMK10.71845846
34WNK40.70870274
35PRKG20.68862645
36STK390.67352866
37CAMK1D0.65246794
38KSR20.64943446
39RPS6KA10.64708057
40PRKG10.63623330
41RIPK40.61710476
42UHMK10.60361351
43BRAF0.60293110
44SGK2230.54556824
45SGK4940.54556824
46MET0.50714417
47ROCK10.50218566
48CAMK40.47124108
49CDK30.47031692
50BMPR1B0.47026426
51PRKAA20.46929922
52MAP3K110.46790916
53GSK3B0.44893250
54CDK20.44047623
55MAPK10.43308776
56LATS20.40770080
57MAP3K20.39709692
58RPS6KL10.39514617
59RPS6KC10.39514617
60LATS10.37937801
61CDK10.37409931
62RPS6KA60.37066213
63MTOR0.36643311
64TIE10.35615696
65PRKCZ0.35149716
66MAP3K80.35082369
67SGK10.33136900
68MAPK80.32318876
69PRKCG0.32056482
70NEK20.31238384
71ZAK0.29076792
72ADRBK20.28924884
73NTRK30.27797578
74MARK10.27240838
75MAP3K10.25620806
76CHEK10.25069584
77CDK40.24904808
78PRKCB0.24843492
79MARK30.23852490
80MAPK140.21849136
81MUSK0.19055401
82OXSR10.18915254
83JAK30.18776739
84RPS6KA50.17579951
85MAP3K40.17261468
86PKN10.17046754
87PRKCE0.15679650
88PRKACA0.14512758
89SGK20.14419466
90MAPK100.12814281
91AKT10.12765998
92TLK10.12310664
93BRSK10.12250693
94BLK0.12191578
95MAP2K70.11847853
96CAMK2A0.11075140
97PRKCA0.10024658
98DYRK30.09881354
99MAPK110.09272948
100EPHA40.09222506

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.56348260
2Fatty acid biosynthesis_Homo sapiens_hsa000616.88932520
3Olfactory transduction_Homo sapiens_hsa047403.93262706
4Butanoate metabolism_Homo sapiens_hsa006502.99623323
5Fatty acid degradation_Homo sapiens_hsa000712.25853172
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.10850846
7Glycerophospholipid metabolism_Homo sapiens_hsa005642.01308697
8Fatty acid metabolism_Homo sapiens_hsa012121.88882002
9Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.83579129
10Dorso-ventral axis formation_Homo sapiens_hsa043201.80261218
11Taste transduction_Homo sapiens_hsa047421.74203674
12Selenocompound metabolism_Homo sapiens_hsa004501.57662318
13Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.55823053
14RNA transport_Homo sapiens_hsa030131.41722490
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31823129
16Phenylalanine metabolism_Homo sapiens_hsa003601.26263910
17Type II diabetes mellitus_Homo sapiens_hsa049301.24040016
18Adipocytokine signaling pathway_Homo sapiens_hsa049201.23715987
19Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.20945671
20PPAR signaling pathway_Homo sapiens_hsa033201.18249096
21Phototransduction_Homo sapiens_hsa047441.15050808
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14913741
23ABC transporters_Homo sapiens_hsa020101.13840866
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04517993
25Glycerolipid metabolism_Homo sapiens_hsa005611.04072697
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04005219
27Nicotine addiction_Homo sapiens_hsa050331.01520320
28Protein digestion and absorption_Homo sapiens_hsa049740.98863036
29Circadian entrainment_Homo sapiens_hsa047130.97992570
30Arginine and proline metabolism_Homo sapiens_hsa003300.95489525
31Hedgehog signaling pathway_Homo sapiens_hsa043400.94970343
32Calcium signaling pathway_Homo sapiens_hsa040200.93857692
33Morphine addiction_Homo sapiens_hsa050320.92595530
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90981382
35Arginine biosynthesis_Homo sapiens_hsa002200.90745936
36Synaptic vesicle cycle_Homo sapiens_hsa047210.89756985
37Type I diabetes mellitus_Homo sapiens_hsa049400.88052331
38Nitrogen metabolism_Homo sapiens_hsa009100.86421293
39Antigen processing and presentation_Homo sapiens_hsa046120.84194636
40Inositol phosphate metabolism_Homo sapiens_hsa005620.81829437
41cAMP signaling pathway_Homo sapiens_hsa040240.81478340
42Salivary secretion_Homo sapiens_hsa049700.80985371
43Primary bile acid biosynthesis_Homo sapiens_hsa001200.79480933
44Renin-angiotensin system_Homo sapiens_hsa046140.76796992
45Glutamatergic synapse_Homo sapiens_hsa047240.74913820
46Autoimmune thyroid disease_Homo sapiens_hsa053200.71759655
47Allograft rejection_Homo sapiens_hsa053300.71159980
48Graft-versus-host disease_Homo sapiens_hsa053320.70174412
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69482956
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68633067
51Endocytosis_Homo sapiens_hsa041440.67943114
52Bile secretion_Homo sapiens_hsa049760.67873249
53Estrogen signaling pathway_Homo sapiens_hsa049150.64463366
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62980145
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61618748
56Oocyte meiosis_Homo sapiens_hsa041140.61335467
57GABAergic synapse_Homo sapiens_hsa047270.58268548
58Purine metabolism_Homo sapiens_hsa002300.56560626
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56019474
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53826412
61Tyrosine metabolism_Homo sapiens_hsa003500.52591829
62Biosynthesis of amino acids_Homo sapiens_hsa012300.51321377
63Retinol metabolism_Homo sapiens_hsa008300.51155800
64Renin secretion_Homo sapiens_hsa049240.50906153
65Gastric acid secretion_Homo sapiens_hsa049710.50437758
66Viral myocarditis_Homo sapiens_hsa054160.50079877
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49715789
68Cardiac muscle contraction_Homo sapiens_hsa042600.48906057
69Fat digestion and absorption_Homo sapiens_hsa049750.48904534
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47714822
71Cholinergic synapse_Homo sapiens_hsa047250.43488462
72Influenza A_Homo sapiens_hsa051640.42721763
73Tight junction_Homo sapiens_hsa045300.42419983
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.41668542
75Tryptophan metabolism_Homo sapiens_hsa003800.41071097
76Serotonergic synapse_Homo sapiens_hsa047260.39393446
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.38924959
78ECM-receptor interaction_Homo sapiens_hsa045120.38891008
79Amphetamine addiction_Homo sapiens_hsa050310.37701333
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.37171989
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34263633
82Insulin secretion_Homo sapiens_hsa049110.34054944
83Fanconi anemia pathway_Homo sapiens_hsa034600.31668429
84Mineral absorption_Homo sapiens_hsa049780.30870143
85MAPK signaling pathway_Homo sapiens_hsa040100.30280741
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30167207
87Oxytocin signaling pathway_Homo sapiens_hsa049210.26626730
88Basal transcription factors_Homo sapiens_hsa030220.26053226
89Pancreatic secretion_Homo sapiens_hsa049720.25513496
90VEGF signaling pathway_Homo sapiens_hsa043700.24850478
91Alcoholism_Homo sapiens_hsa050340.24651338
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.22701818
93Linoleic acid metabolism_Homo sapiens_hsa005910.22613868
94Gap junction_Homo sapiens_hsa045400.22432965
95Prolactin signaling pathway_Homo sapiens_hsa049170.21850350
96beta-Alanine metabolism_Homo sapiens_hsa004100.21429623
97mRNA surveillance pathway_Homo sapiens_hsa030150.21049266
98Metabolic pathways_Homo sapiens_hsa011000.20785538
99Choline metabolism in cancer_Homo sapiens_hsa052310.19693488
100Peroxisome_Homo sapiens_hsa041460.19693288

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