OR11N1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of action potential (GO:0098900)9.99732255
2positive regulation of cardiac muscle hypertrophy (GO:0010613)8.65862429
3positive regulation of muscle hypertrophy (GO:0014742)8.65862429
4regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO8.57047889
5response to pheromone (GO:0019236)7.89457867
6endoplasmic reticulum calcium ion homeostasis (GO:0032469)7.56340146
7regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)7.43811325
8relaxation of muscle (GO:0090075)6.89703946
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.65448831
10regulation of heart rate by cardiac conduction (GO:0086091)6.53996745
11regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.64873351
12regulation of the force of heart contraction (GO:0002026)5.56204952
13fatty acid elongation (GO:0030497)5.31746252
14regulation of cardiac muscle hypertrophy (GO:0010611)5.24054462
15cardiac conduction (GO:0061337)5.23396392
16regulation of muscle hypertrophy (GO:0014743)5.03277294
17anatomical structure regression (GO:0060033)4.81488588
18regulation of histone deacetylation (GO:0031063)4.80647493
19protein localization to cilium (GO:0061512)4.58788337
20reverse cholesterol transport (GO:0043691)4.48572975
21platelet dense granule organization (GO:0060155)4.47099600
22keratinocyte development (GO:0003334)4.46366569
23regulation of sodium ion transmembrane transporter activity (GO:2000649)4.36526301
24regulation of cardiac muscle contraction (GO:0055117)4.05085606
25negative regulation of ion transmembrane transporter activity (GO:0032413)3.95728420
26kinetochore organization (GO:0051383)3.94211507
27DNA strand renaturation (GO:0000733)3.93811925
28kinetochore assembly (GO:0051382)3.88662261
29DNA integration (GO:0015074)3.79103747
30L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.74677678
31regulation of muscle adaptation (GO:0043502)3.61922916
32regulation of sodium ion transmembrane transport (GO:1902305)3.60350865
33regulation of membrane depolarization (GO:0003254)3.54871823
34multicellular organismal signaling (GO:0035637)3.54484227
35neural tube formation (GO:0001841)3.51131824
36peptidyl-arginine N-methylation (GO:0035246)3.37393952
37peptidyl-arginine methylation (GO:0018216)3.37393952
38negative regulation of transporter activity (GO:0032410)3.33003905
39hindbrain development (GO:0030902)3.30761981
40phospholipid efflux (GO:0033700)3.29385559
41negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.25853784
42negative regulation of translation, ncRNA-mediated (GO:0040033)3.25853784
43regulation of translation, ncRNA-mediated (GO:0045974)3.25853784
44phospholipid homeostasis (GO:0055091)3.24291388
45proteasome assembly (GO:0043248)3.21514525
46regulation of protein deacetylation (GO:0090311)3.21382342
47cellular response to leptin stimulus (GO:0044320)3.19035818
48replication fork processing (GO:0031297)3.18678703
49regulation of striated muscle contraction (GO:0006942)3.17568321
50preassembly of GPI anchor in ER membrane (GO:0016254)3.14465473
51protein localization to kinetochore (GO:0034501)3.13883925
52regulation of cardiac muscle cell contraction (GO:0086004)3.13018336
53plasma lipoprotein particle assembly (GO:0034377)3.07131814
54regulation of cilium movement (GO:0003352)3.07003876
55negative regulation of ion transmembrane transport (GO:0034766)3.03015654
56somatic hypermutation of immunoglobulin genes (GO:0016446)3.02977029
57somatic diversification of immune receptors via somatic mutation (GO:0002566)3.02977029
58actin-mediated cell contraction (GO:0070252)3.01767746
59glial cell proliferation (GO:0014009)2.98665549
60coenzyme catabolic process (GO:0009109)2.96296667
61L-methionine salvage (GO:0071267)2.96001580
62L-methionine biosynthetic process (GO:0071265)2.96001580
63amino acid salvage (GO:0043102)2.96001580
64cellular response to calcium ion (GO:0071277)2.95819821
65response to lipoprotein particle (GO:0055094)2.91396902
66tRNA methylation (GO:0030488)2.91328198
67regulation of calcium ion transmembrane transporter activity (GO:1901019)2.86535406
68regulation of calcium ion transmembrane transport (GO:1903169)2.86535406
69L-serine transport (GO:0015825)2.85648729
70C-terminal protein lipidation (GO:0006501)2.81201106
71lipopolysaccharide biosynthetic process (GO:0009103)2.79372923
72regulation of release of sequestered calcium ion into cytosol (GO:0051279)2.79221106
73oligodendrocyte development (GO:0014003)2.78681318
74negative regulation of transmembrane transport (GO:0034763)2.77782459
75ER overload response (GO:0006983)2.77729094
76mitochondrial RNA metabolic process (GO:0000959)2.72228907
77branch elongation of an epithelium (GO:0060602)2.66313849
78artery smooth muscle contraction (GO:0014824)2.63213718
79midbrain development (GO:0030901)2.58772846
80ventricular system development (GO:0021591)2.57978928
81peptidyl-threonine phosphorylation (GO:0018107)2.57814131
82S-adenosylmethionine metabolic process (GO:0046500)2.54731573
83tricarboxylic acid metabolic process (GO:0072350)2.53181223
84dicarboxylic acid catabolic process (GO:0043649)2.51977980
85positive regulation of p38MAPK cascade (GO:1900745)2.51346625
86cullin deneddylation (GO:0010388)2.50477820
87tricarboxylic acid cycle (GO:0006099)2.49794495
88histamine secretion (GO:0001821)2.48484279
89serine transport (GO:0032329)2.47303843
90protein-lipid complex assembly (GO:0065005)2.46815349
91protein K11-linked ubiquitination (GO:0070979)2.45093987
92response to leptin (GO:0044321)2.44236081
93regulation of sulfur metabolic process (GO:0042762)2.44109709
94pentose metabolic process (GO:0019321)2.43070206
95intraciliary transport (GO:0042073)2.42708233
96meiotic chromosome segregation (GO:0045132)2.42576038
97regulation of relaxation of muscle (GO:1901077)18.3274829
98negative regulation of sodium ion transport (GO:0010766)15.1087747
99regulation of cell communication by electrical coupling (GO:0010649)14.4579972
100relaxation of cardiac muscle (GO:0055119)12.1645329

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD_19615063_ChIP-ChIP_OVARY_Human7.89716209
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.18037133
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.59851914
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.87627760
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.81461308
6GBX2_23144817_ChIP-Seq_PC3_Human2.76148593
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.48230042
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.32655709
9PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27002126
10ZNF274_21170338_ChIP-Seq_K562_Hela2.25046326
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96678509
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.95973897
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.94668986
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91092307
15POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85413644
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85284099
17VDR_22108803_ChIP-Seq_LS180_Human1.72239874
18ELK1_19687146_ChIP-ChIP_HELA_Human1.70153855
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.69967418
20E2F4_17652178_ChIP-ChIP_JURKAT_Human1.69506426
21EGR1_23403033_ChIP-Seq_LIVER_Mouse1.66864959
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65603528
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62884891
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58821201
25BCAT_22108803_ChIP-Seq_LS180_Human1.58774829
26TP53_22573176_ChIP-Seq_HFKS_Human1.57482376
27SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56620622
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55834888
29TCF4_22108803_ChIP-Seq_LS180_Human1.55778981
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.55070998
31TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.54186955
32CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53296413
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49596576
34HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.48620774
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45441159
36P300_19829295_ChIP-Seq_ESCs_Human1.43266730
37TP53_16413492_ChIP-PET_HCT116_Human1.42258721
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39068482
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38917957
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38003648
41GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30694806
42RXR_22108803_ChIP-Seq_LS180_Human1.30678081
43NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.29213465
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27908729
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27488748
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.26788278
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25972229
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25642336
49FUS_26573619_Chip-Seq_HEK293_Human1.25071031
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24227635
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.18578250
52FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18578250
53PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15796122
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13673579
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12221089
56KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11437561
57FOXH1_21741376_ChIP-Seq_EPCs_Human1.11393155
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11107088
59CDX2_22108803_ChIP-Seq_LS180_Human1.10526975
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09236412
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08304270
62SMAD4_21741376_ChIP-Seq_EPCs_Human1.07729229
63SMAD3_21741376_ChIP-Seq_HESCs_Human1.07588863
64AR_21909140_ChIP-Seq_LNCAP_Human1.07584749
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06784523
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06437092
67SMAD4_21741376_ChIP-Seq_HESCs_Human1.06301509
68E2F1_18555785_Chip-Seq_ESCs_Mouse1.05504358
69LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05302058
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03679053
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03309868
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02040712
73AR_25329375_ChIP-Seq_VCAP_Human1.01805489
74BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01204949
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99751664
76AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99418122
77FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.98865581
78PRDM14_20953172_ChIP-Seq_ESCs_Human0.98360702
79STAT3_23295773_ChIP-Seq_U87_Human0.97998707
80NANOG_19829295_ChIP-Seq_ESCs_Human0.97788973
81SOX2_19829295_ChIP-Seq_ESCs_Human0.97788973
82KDM2B_26808549_Chip-Seq_REH_Human0.97124362
83SRF_21415370_ChIP-Seq_HL-1_Mouse0.96594568
84RUNX2_22187159_ChIP-Seq_PCA_Human0.96366630
85PIAS1_25552417_ChIP-Seq_VCAP_Human0.96113564
86KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95721581
87SOX9_26525672_Chip-Seq_HEART_Mouse0.95663609
88DCP1A_22483619_ChIP-Seq_HELA_Human0.95279552
89FOXP3_21729870_ChIP-Seq_TREG_Human0.93369135
90NANOG_18555785_Chip-Seq_ESCs_Mouse0.92593274
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92401039
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89868681
93P300_18555785_Chip-Seq_ESCs_Mouse0.89235522
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88538827
95CBP_20019798_ChIP-Seq_JUKART_Human0.88538827
96VDR_23849224_ChIP-Seq_CD4+_Human0.87739121
97FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87615057
98EWS_26573619_Chip-Seq_HEK293_Human0.86501538
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85010358
100NOTCH1_21737748_ChIP-Seq_TLL_Human0.82078634

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat8.88522127
2MP0003880_abnormal_central_pattern5.36337960
3MP0005423_abnormal_somatic_nervous4.74400494
4MP0008995_early_reproductive_senescence4.13151459
5MP0004484_altered_response_of3.56631155
6MP0003136_yellow_coat_color3.27762389
7MP0001661_extended_life_span3.21788401
8MP0001984_abnormal_olfaction2.99104659
9MP0000372_irregular_coat_pigmentation2.75637843
10MP0008877_abnormal_DNA_methylation2.42763270
11MP0005166_decreased_susceptibility_to2.24738918
12MP0000579_abnormal_nail_morphology2.18043822
13MP0001485_abnormal_pinna_reflex2.10539683
14MP0005075_abnormal_melanosome_morpholog1.93190891
15MP0005551_abnormal_eye_electrophysiolog1.93001185
16MP0003191_abnormal_cellular_cholesterol1.92012065
17MP0003786_premature_aging1.81629940
18MP0003122_maternal_imprinting1.73779293
19MP0000383_abnormal_hair_follicle1.68325571
20MP0002132_abnormal_respiratory_system1.57025923
21MP0005275_abnormal_skin_tensile1.55553916
22MP0000647_abnormal_sebaceous_gland1.53191875
23MP0000604_amyloidosis1.51447938
24MP0004133_heterotaxia1.44719935
25MP0008260_abnormal_autophagy1.44625452
26MP0002163_abnormal_gland_morphology1.41734476
27MP0005253_abnormal_eye_physiology1.40530979
28MP0003646_muscle_fatigue1.37032408
29MP0002736_abnormal_nociception_after1.33907018
30MP0004019_abnormal_vitamin_homeostasis1.33615483
31MP0005645_abnormal_hypothalamus_physiol1.30419190
32MP0000427_abnormal_hair_cycle1.30008729
33MP0004043_abnormal_pH_regulation1.27518811
34MP0006054_spinal_hemorrhage1.24413704
35MP0004215_abnormal_myocardial_fiber1.21506064
36MP0001764_abnormal_homeostasis1.20648280
37MP0002938_white_spotting1.18768702
38MP0003941_abnormal_skin_development1.18273506
39MP0008057_abnormal_DNA_replication1.15428513
40MP0001666_abnormal_nutrient_absorption1.14531679
41MP0002090_abnormal_vision1.13733799
42MP0001873_stomach_inflammation1.12905183
43MP0003693_abnormal_embryo_hatching1.11683817
44MP0004885_abnormal_endolymph1.06299096
45MP0005410_abnormal_fertilization1.02910187
46MP0001486_abnormal_startle_reflex1.01424908
47MP0003186_abnormal_redox_activity1.00783708
48MP0002295_abnormal_pulmonary_circulatio1.00768357
49MP0001324_abnormal_eye_pigmentation1.00260927
50MP0010094_abnormal_chromosome_stability0.94980318
51MP0000749_muscle_degeneration0.93256569
52MP0001853_heart_inflammation0.92338141
53MP0008872_abnormal_physiological_respon0.91113327
54MP0001968_abnormal_touch/_nociception0.90826124
55MP0001986_abnormal_taste_sensitivity0.89191383
56MP0005636_abnormal_mineral_homeostasis0.88924058
57MP0003111_abnormal_nucleus_morphology0.88726937
58MP0001756_abnormal_urination0.83832792
59MP0006072_abnormal_retinal_apoptosis0.83247372
60MP0003221_abnormal_cardiomyocyte_apopto0.82714963
61MP0003385_abnormal_body_wall0.80263935
62MP0010329_abnormal_lipoprotein_level0.79366297
63MP0009703_decreased_birth_body0.76926513
64MP0001849_ear_inflammation0.76592931
65MP0009697_abnormal_copulation0.75367907
66MP0004883_abnormal_blood_vessel0.75328228
67MP0001502_abnormal_circadian_rhythm0.73650269
68MP0004381_abnormal_hair_follicle0.71687300
69MP0005391_vision/eye_phenotype0.69146915
70MP0003121_genomic_imprinting0.69108120
71MP0010678_abnormal_skin_adnexa0.68020660
72MP0004145_abnormal_muscle_electrophysio0.67223344
73MP0000639_abnormal_adrenal_gland0.66479053
74MP0002136_abnormal_kidney_physiology0.65471808
75MP0003119_abnormal_digestive_system0.65443718
76MP0002734_abnormal_mechanical_nocicepti0.65378485
77MP0003718_maternal_effect0.65298448
78MP0005365_abnormal_bile_salt0.65011791
79MP0005195_abnormal_posterior_eye0.64482870
80MP0008058_abnormal_DNA_repair0.64082441
81MP0005379_endocrine/exocrine_gland_phen0.63902171
82MP0005197_abnormal_uvea_morphology0.61904350
83MP0005310_abnormal_salivary_gland0.61450081
84MP0005330_cardiomyopathy0.58522532
85MP0002138_abnormal_hepatobiliary_system0.57508078
86MP0006292_abnormal_olfactory_placode0.56415147
87MP0003937_abnormal_limbs/digits/tail_de0.56186674
88MP0000049_abnormal_middle_ear0.54094706
89MP0003077_abnormal_cell_cycle0.53388556
90MP0005332_abnormal_amino_acid0.53050118
91MP0004957_abnormal_blastocyst_morpholog0.51604239
92MP0001915_intracranial_hemorrhage0.49633707
93MP0000751_myopathy0.46726094
94MP0001727_abnormal_embryo_implantation0.46636924
95MP0001851_eye_inflammation0.45585247
96MP0002229_neurodegeneration0.44977851
97MP0003950_abnormal_plasma_membrane0.44013328
98MP0003806_abnormal_nucleotide_metabolis0.43774032
99MP0002653_abnormal_ependyma_morphology0.41577101
100MP0005084_abnormal_gallbladder_morpholo0.41159936

Predicted human phenotypes

RankGene SetZ-score
1Hypoalphalipoproteinemia (HP:0003233)5.65476210
2Congenital, generalized hypertrichosis (HP:0004540)4.43201162
3Facial diplegia (HP:0001349)4.38940724
4Amelogenesis imperfecta (HP:0000705)4.22039704
5Pili torti (HP:0003777)4.17490077
6Acute lymphatic leukemia (HP:0006721)4.12645653
7Cerebral hypomyelination (HP:0006808)4.09136277
8Follicular hyperkeratosis (HP:0007502)4.08749524
9High pitched voice (HP:0001620)3.95937982
10Action tremor (HP:0002345)3.93340464
11Aplasia/Hypoplasia of the tibia (HP:0005772)3.69072153
12Short tibia (HP:0005736)3.40433965
13CNS hypomyelination (HP:0003429)3.30923237
14Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.25519401
15Abnormality of alanine metabolism (HP:0010916)3.25519401
16Hyperalaninemia (HP:0003348)3.25519401
17Hypoplasia of the capital femoral epiphysis (HP:0003090)3.17589492
18Hypolipoproteinemia (HP:0010981)3.15467476
19Hyperglycinemia (HP:0002154)3.13260112
20Nephronophthisis (HP:0000090)3.03198165
21CNS demyelination (HP:0007305)2.91806339
22Methylmalonic acidemia (HP:0002912)2.85367191
23Hepatocellular necrosis (HP:0001404)2.81916202
24Delusions (HP:0000746)2.81462549
25Abnormal hair laboratory examination (HP:0003328)2.77006276
26Brittle hair (HP:0002299)2.76415389
27Methylmalonic aciduria (HP:0012120)2.76379427
28Occipital encephalocele (HP:0002085)2.66259894
29Hepatic necrosis (HP:0002605)2.60302830
30Cerebellar dysplasia (HP:0007033)2.50120348
31Concave nail (HP:0001598)2.49783639
32Abnormality of the ischium (HP:0003174)2.47305795
33Sparse eyelashes (HP:0000653)2.46953615
34Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.44795402
35Absent epiphyses (HP:0010577)2.44795402
36Aplasia/Hypoplasia of the tongue (HP:0010295)2.35086031
37Double outlet right ventricle (HP:0001719)2.31629559
38Congenital malformation of the right heart (HP:0011723)2.31629559
39Duplicated collecting system (HP:0000081)2.31569845
40Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.31155798
41Molar tooth sign on MRI (HP:0002419)2.28299420
42Abnormality of midbrain morphology (HP:0002418)2.28299420
43Large for gestational age (HP:0001520)2.27174403
44Disproportionate short-trunk short stature (HP:0003521)2.26502378
45Severe muscular hypotonia (HP:0006829)2.25108477
46Ectropion (HP:0000656)2.24969558
47Type I transferrin isoform profile (HP:0003642)2.24933363
48Postaxial foot polydactyly (HP:0001830)2.24804304
49Abnormality of the renal medulla (HP:0100957)2.23729839
50Hepatoblastoma (HP:0002884)2.22705849
51Premature ovarian failure (HP:0008209)2.22700500
52Fragile skin (HP:0001030)2.22130669
53Decreased activity of mitochondrial respiratory chain (HP:0008972)2.21619141
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.21619141
55Impaired pain sensation (HP:0007328)2.19366506
56Abnormality of pain sensation (HP:0010832)2.19366506
57Disinhibition (HP:0000734)2.18007488
58Abnormality of the renal collecting system (HP:0004742)2.15743226
59Microretrognathia (HP:0000308)2.14036434
60Emotional lability (HP:0000712)2.13832766
61True hermaphroditism (HP:0010459)2.13545638
62Pancreatic fibrosis (HP:0100732)2.12559041
63Tubulointerstitial nephritis (HP:0001970)2.11984702
64Pancreatic cysts (HP:0001737)2.11074372
65Abnormality of serum amino acid levels (HP:0003112)2.09346377
66Abnormal protein glycosylation (HP:0012346)2.04576359
67Abnormal glycosylation (HP:0012345)2.04576359
68Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.04576359
69Abnormal protein N-linked glycosylation (HP:0012347)2.04576359
70Woolly hair (HP:0002224)2.00547787
71Ulnar claw (HP:0001178)1.93383918
72Acute encephalopathy (HP:0006846)1.92081094
73Lactic acidosis (HP:0003128)1.91103878
74Neutropenia (HP:0001875)1.90826640
75Secondary amenorrhea (HP:0000869)1.88201511
76Myokymia (HP:0002411)1.86605029
77Lethargy (HP:0001254)1.84391227
78Absent radius (HP:0003974)1.83261417
79Anal stenosis (HP:0002025)1.82971350
80Optic nerve hypoplasia (HP:0000609)1.82722423
81Abnormality of the lower motor neuron (HP:0002366)1.82014054
82Progressive inability to walk (HP:0002505)1.79128000
83Small hand (HP:0200055)1.78780433
84Intestinal atresia (HP:0011100)1.75145458
85Mitochondrial inheritance (HP:0001427)1.74768538
86Stage 5 chronic kidney disease (HP:0003774)1.74069573
87Increased CSF lactate (HP:0002490)1.73292145
88Areflexia of lower limbs (HP:0002522)1.72723309
89Aplasia involving forearm bones (HP:0009822)1.71937171
90Absent forearm bone (HP:0003953)1.71937171
91Postaxial hand polydactyly (HP:0001162)1.70679890
92Median cleft lip (HP:0000161)1.69371780
93Central scotoma (HP:0000603)1.67805536
94Preaxial hand polydactyly (HP:0001177)1.67331568
95Hypoplastic female external genitalia (HP:0012815)1.66833617
96Spastic tetraparesis (HP:0001285)1.66491672
97Absent eyebrow (HP:0002223)1.65524638
98Medial flaring of the eyebrow (HP:0010747)1.63368743
99Abnormality of macular pigmentation (HP:0008002)1.63113211
100Abnormality of the vitamin B12 metabolism (HP:0004341)1.62145139

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM285.89290603
2SIK35.34535055
3MAP4K24.00931559
4TNIK3.03186834
5PINK12.61746359
6BCR2.51287627
7NEK62.47367495
8STK162.18146000
9KSR12.09105542
10CAMK2D2.08378302
11PDK210.0601138
12RPS6KB11.90903308
13GRK11.87798025
14FRK1.76797961
15MST1R1.76189463
16BCKDK1.58741849
17WEE11.54853626
18FES1.38185012
19ZAK1.30465247
20MINK11.29183107
21NEK11.21502208
22NEK91.13483881
23NLK1.13320198
24MET1.13016660
25NTRK20.95435201
26SRPK10.94006721
27STK390.92806921
28NEK20.91504367
29BMPR1B0.90814407
30BUB10.90544969
31PTK2B0.79599864
32MAPK70.78505270
33TTK0.75619232
34TRPM70.74248964
35WNK40.72669882
36PBK0.70298367
37PAK30.63673306
38STK30.59111193
39MUSK0.53134782
40CDK30.52841664
41VRK20.52491028
42BRSK10.51953572
43OBSCN0.51426408
44CDK90.46575275
45PRKCG0.45331836
46BRSK20.44877131
47FGR0.44701746
48MAPK120.43491785
49STK40.42582385
50KSR20.41760209
51OXSR10.41734184
52TIE10.40054405
53ATR0.38468629
54PLK10.37948030
55MAP3K20.36015543
56ERBB40.35325055
57ADRBK20.33769996
58MAPK90.33151910
59CDK70.33047844
60CCNB10.30988379
61PRKCB0.30945630
62ICK0.29858929
63EIF2AK20.29593384
64PLK30.29221856
65PRKCE0.28339712
66CSF1R0.28241826
67CDK80.25733087
68PDK10.25633527
69WNK30.25064004
70MELK0.23094109
71PDPK10.21545578
72STK380.21344368
73LMTK20.19182972
74MAP3K140.18889857
75MST40.18620249
76PIK3CA0.17633793
77PRKACG0.17283489
78BRD40.17262758
79CSNK2A10.16894838
80PRKACA0.15576743
81CHEK10.13079523
82CAMK2A0.12957026
83CDK20.12594401
84PLK40.12383610
85MARK10.11361830
86INSR0.10898339
87EGFR0.09433114
88MAP2K20.07975128
89MAP3K80.07975093
90MAP2K60.07942762
91TGFBR10.07308188
92CDK180.06953908
93GSK3B0.06911207
94AKT30.06351060
95MAP4K10.05014287
96CDK190.04827556
97CSNK2A20.04701324
98PKN10.04624395
99MAPK100.03837887
100MTOR0.03023939

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.66017167
2Fatty acid elongation_Homo sapiens_hsa000623.28313577
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.13145107
4Propanoate metabolism_Homo sapiens_hsa006402.62901396
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.59720243
6Oocyte meiosis_Homo sapiens_hsa041142.55719229
7Olfactory transduction_Homo sapiens_hsa047402.44836676
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.31487147
9Nitrogen metabolism_Homo sapiens_hsa009102.03414784
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.02623561
11Gastric acid secretion_Homo sapiens_hsa049711.97012117
12Insulin secretion_Homo sapiens_hsa049111.86358402
13Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.82159717
14Glioma_Homo sapiens_hsa052141.81920532
15Amphetamine addiction_Homo sapiens_hsa050311.80699878
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79043972
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73705855
18Basal transcription factors_Homo sapiens_hsa030221.70358148
19Proteasome_Homo sapiens_hsa030501.69049748
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68418252
21Fat digestion and absorption_Homo sapiens_hsa049751.66780990
22Renin-angiotensin system_Homo sapiens_hsa046141.52581257
23One carbon pool by folate_Homo sapiens_hsa006701.52056113
24RNA polymerase_Homo sapiens_hsa030201.52005006
25Fatty acid metabolism_Homo sapiens_hsa012121.50498161
26Oxidative phosphorylation_Homo sapiens_hsa001901.46882825
27Protein export_Homo sapiens_hsa030601.46477315
28Circadian entrainment_Homo sapiens_hsa047131.43915448
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.41119013
30Homologous recombination_Homo sapiens_hsa034401.37223926
31Fanconi anemia pathway_Homo sapiens_hsa034601.36141829
32Long-term potentiation_Homo sapiens_hsa047201.33470017
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33019982
34Melanogenesis_Homo sapiens_hsa049161.32788721
35Mismatch repair_Homo sapiens_hsa034301.26504177
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24273063
37ABC transporters_Homo sapiens_hsa020101.16612123
38Glucagon signaling pathway_Homo sapiens_hsa049221.16526250
39TGF-beta signaling pathway_Homo sapiens_hsa043501.14800497
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10454605
41Pyruvate metabolism_Homo sapiens_hsa006201.09856647
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.08956140
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07284117
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07236809
45Linoleic acid metabolism_Homo sapiens_hsa005911.05377003
46Peroxisome_Homo sapiens_hsa041461.00269803
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94279745
48Parkinsons disease_Homo sapiens_hsa050120.94009713
49Butanoate metabolism_Homo sapiens_hsa006500.93273075
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.93193265
51Nucleotide excision repair_Homo sapiens_hsa034200.93009206
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88126908
53HIF-1 signaling pathway_Homo sapiens_hsa040660.87820480
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86803202
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82661421
56Retinol metabolism_Homo sapiens_hsa008300.82040676
57Dopaminergic synapse_Homo sapiens_hsa047280.81831258
58Wnt signaling pathway_Homo sapiens_hsa043100.81828264
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81640479
60Selenocompound metabolism_Homo sapiens_hsa004500.80100670
61Vitamin B6 metabolism_Homo sapiens_hsa007500.80075934
62Calcium signaling pathway_Homo sapiens_hsa040200.79590621
63Lysine degradation_Homo sapiens_hsa003100.78845676
64Carbon metabolism_Homo sapiens_hsa012000.76321161
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76002437
66ErbB signaling pathway_Homo sapiens_hsa040120.75878402
67GnRH signaling pathway_Homo sapiens_hsa049120.75228911
68Cholinergic synapse_Homo sapiens_hsa047250.71492541
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71356728
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.70860154
71Tryptophan metabolism_Homo sapiens_hsa003800.70801783
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70665269
73Phototransduction_Homo sapiens_hsa047440.69044975
74beta-Alanine metabolism_Homo sapiens_hsa004100.68389468
75cAMP signaling pathway_Homo sapiens_hsa040240.68170283
76Oxytocin signaling pathway_Homo sapiens_hsa049210.65856698
77Collecting duct acid secretion_Homo sapiens_hsa049660.64548393
78Cell cycle_Homo sapiens_hsa041100.61473961
79Glutathione metabolism_Homo sapiens_hsa004800.59743744
80Biosynthesis of amino acids_Homo sapiens_hsa012300.59304313
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58908985
82Hedgehog signaling pathway_Homo sapiens_hsa043400.58809343
83RNA degradation_Homo sapiens_hsa030180.58762909
84Fatty acid degradation_Homo sapiens_hsa000710.56048944
85Ether lipid metabolism_Homo sapiens_hsa005650.55331922
86Mineral absorption_Homo sapiens_hsa049780.55151116
87Purine metabolism_Homo sapiens_hsa002300.54417140
88Huntingtons disease_Homo sapiens_hsa050160.54111083
89Chemical carcinogenesis_Homo sapiens_hsa052040.53228431
90Spliceosome_Homo sapiens_hsa030400.52175738
91RNA transport_Homo sapiens_hsa030130.49483709
92Metabolic pathways_Homo sapiens_hsa011000.45767921
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44164599
94Arginine and proline metabolism_Homo sapiens_hsa003300.43824365
95Alzheimers disease_Homo sapiens_hsa050100.42683184
96Basal cell carcinoma_Homo sapiens_hsa052170.41457592
97Cardiac muscle contraction_Homo sapiens_hsa042600.39768393
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.39154176
99Arginine biosynthesis_Homo sapiens_hsa002200.37421572
100N-Glycan biosynthesis_Homo sapiens_hsa005100.36892734

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