OR13A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1B cell receptor signaling pathway (GO:0050853)8.10771272
2regulation of protein glycosylation (GO:0060049)7.47734139
3B cell proliferation (GO:0042100)7.32929800
4regulation of histone H3-K27 methylation (GO:0061085)6.32199982
5regulation of B cell receptor signaling pathway (GO:0050855)5.98428264
6positive regulation of B cell differentiation (GO:0045579)5.26105554
7positive regulation of gamma-delta T cell activation (GO:0046645)5.24531985
8V(D)J recombination (GO:0033151)5.03716269
9positive regulation of protein homooligomerization (GO:0032464)4.79735990
10post-embryonic morphogenesis (GO:0009886)4.37470162
11regulation of B cell differentiation (GO:0045577)4.35590208
12germinal center formation (GO:0002467)4.18167919
13B cell homeostasis (GO:0001782)4.09902182
14histone H3-K9 modification (GO:0061647)4.06911551
15regulation of glycoprotein biosynthetic process (GO:0010559)3.89147719
16B cell activation (GO:0042113)3.80830238
17regulation of gamma-delta T cell differentiation (GO:0045586)3.73933355
18DNA ligation (GO:0006266)3.73828441
19lymphocyte proliferation (GO:0046651)3.71777991
20N-terminal protein amino acid acetylation (GO:0006474)3.65480432
21regulation of gamma-delta T cell activation (GO:0046643)3.64855370
22cellular response to virus (GO:0098586)3.64299277
23mononuclear cell proliferation (GO:0032943)3.63718905
24positive regulation of mast cell activation involved in immune response (GO:0033008)3.63636397
25positive regulation of mast cell degranulation (GO:0043306)3.63636397
26regulation of germinal center formation (GO:0002634)3.50554277
27peptidyl-lysine trimethylation (GO:0018023)3.37792855
28neutrophil activation involved in immune response (GO:0002283)3.37393439
29positive regulation of mRNA 3-end processing (GO:0031442)3.34160787
30positive regulation of B cell proliferation (GO:0030890)3.32705003
31T cell lineage commitment (GO:0002360)3.29127076
32positive regulation by host of viral transcription (GO:0043923)3.26705297
33somatic cell DNA recombination (GO:0016444)3.25635874
34somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.25635874
35leukocyte proliferation (GO:0070661)3.25536133
36antigen receptor-mediated signaling pathway (GO:0050851)3.23697989
37positive regulation of developmental pigmentation (GO:0048087)3.23562257
38regulation of B cell proliferation (GO:0030888)3.22936643
39CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.22689721
40positive regulation of B cell activation (GO:0050871)3.22337135
41histone H3 deacetylation (GO:0070932)3.21806696
42natural killer cell differentiation (GO:0001779)3.19426762
43positive regulation of protein oligomerization (GO:0032461)3.18891956
44immunoglobulin mediated immune response (GO:0016064)3.18741704
45positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.17182554
46production of molecular mediator involved in inflammatory response (GO:0002532)3.16471805
47regulation of glycoprotein metabolic process (GO:1903018)3.15473524
48somatic diversification of immune receptors (GO:0002200)3.14820797
49mRNA cleavage (GO:0006379)3.14722865
50mature B cell differentiation (GO:0002335)3.14021831
51negative regulation of calcium ion transport into cytosol (GO:0010523)3.12472859
52DNA topological change (GO:0006265)3.12348363
53somatic recombination of immunoglobulin gene segments (GO:0016447)3.12066742
54regulation of protein heterodimerization activity (GO:0043497)3.11785854
55meiotic chromosome segregation (GO:0045132)3.10811608
56regulation of gene expression by genetic imprinting (GO:0006349)3.10066618
57regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.10005778
58intra-S DNA damage checkpoint (GO:0031573)3.09009149
59regulation of histone H3-K9 methylation (GO:0051570)3.08076331
60lymphoid progenitor cell differentiation (GO:0002320)3.07972332
61regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.02254514
62positive regulation of DNA-templated transcription, initiation (GO:2000144)2.99747457
63somatic diversification of immunoglobulins (GO:0016445)2.98657689
64Peyers patch development (GO:0048541)2.97948834
65mucosal-associated lymphoid tissue development (GO:0048537)2.97948834
66regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.96675932
67positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.96675932
68cellular hyperosmotic response (GO:0071474)2.96079951
69positive thymic T cell selection (GO:0045059)2.94142801
70DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.91248856
71negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.88812327
72single strand break repair (GO:0000012)2.88555159
73macrophage activation involved in immune response (GO:0002281)2.88349266
74hepatocyte apoptotic process (GO:0097284)2.85111443
75B cell activation involved in immune response (GO:0002312)2.84697779
76positive regulation of cell cycle checkpoint (GO:1901978)2.83511373
77regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.82217408
78positive regulation of mast cell activation (GO:0033005)2.79542671
79positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.79357317
80DNA unwinding involved in DNA replication (GO:0006268)2.79234701
81mast cell activation (GO:0045576)2.77794337
82positive regulation of gluconeogenesis (GO:0045722)2.77140007
83regulation of mRNA 3-end processing (GO:0031440)2.75753609
84phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.74978253
85regulation of fibroblast apoptotic process (GO:2000269)2.71941994
86mitotic chromosome condensation (GO:0007076)2.71484009
87telomere maintenance via recombination (GO:0000722)2.70020364
88deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.69920618
89lymphocyte homeostasis (GO:0002260)2.62147806
90vesicle targeting (GO:0006903)2.61998989
91positive regulation of interferon-alpha production (GO:0032727)2.61497233
92negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.60777932
93ear development (GO:0043583)2.59845410
94DNA damage response, signal transduction resulting in transcription (GO:0042772)2.59485510
95regulation of protein homooligomerization (GO:0032462)2.58945396
96T cell homeostasis (GO:0043029)2.58435448
97somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.58213433
98somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.58213433
99isotype switching (GO:0045190)2.58213433
100B cell differentiation (GO:0030183)2.57901945

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.87497394
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.85896077
3MYC_22102868_ChIP-Seq_BL_Human4.88278804
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.86147621
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.03855583
6E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.65658113
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.22668172
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.10114663
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.98231260
10CIITA_25753668_ChIP-Seq_RAJI_Human2.83823273
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.62537609
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.57335092
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.55402492
14MYB_26560356_Chip-Seq_TH2_Human2.32836138
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.25103068
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.23936808
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.21010599
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.02686071
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.99503774
20E2F1_21310950_ChIP-Seq_MCF-7_Human1.90691577
21IRF8_27001747_Chip-Seq_BMDM_Mouse1.85682003
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.80582518
23MYB_26560356_Chip-Seq_TH1_Human1.70582789
24SPI1_23547873_ChIP-Seq_NB4_Human1.62806490
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60116596
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59822941
27RUNX_20019798_ChIP-Seq_JUKART_Human1.55011438
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50140867
29MAF_26560356_Chip-Seq_TH1_Human1.47903122
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.47796408
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.43017595
32GATA3_27048872_Chip-Seq_THYMUS_Human1.41461164
33SCL_19346495_ChIP-Seq_HPC-7_Human1.40630161
34KDM5A_27292631_Chip-Seq_BREAST_Human1.40015712
35VDR_21846776_ChIP-Seq_THP-1_Human1.39283996
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38707690
37SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34431688
38FOXP3_21729870_ChIP-Seq_TREG_Human1.34365324
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33536528
40NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.28318937
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26572449
42PU.1_20513432_ChIP-Seq_Bcells_Mouse1.26403139
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23311115
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23043518
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23043518
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18536634
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17369905
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16685731
49UTX_26944678_Chip-Seq_JUKART_Human1.16678519
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16511054
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15256047
52VDR_23849224_ChIP-Seq_CD4+_Human1.14511030
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14215815
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11186071
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09557892
56MAF_26560356_Chip-Seq_TH2_Human1.07796292
57SMRT_27268052_Chip-Seq_Bcells_Human1.07444514
58SPI1_23127762_ChIP-Seq_K562_Human1.06656203
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06087064
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.04093199
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03456252
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02424152
63BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99768392
64STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99524518
65VDR_24763502_ChIP-Seq_THP-1_Human0.99259329
66GATA3_26560356_Chip-Seq_TH1_Human0.96003337
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94964268
68P300_27268052_Chip-Seq_Bcells_Human0.94943386
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94310788
70STAT4_19710469_ChIP-ChIP_TH1__Mouse0.91469406
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91242224
72HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90151839
73MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90067248
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89267862
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.87395022
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87268143
77TCF7_22412390_ChIP-Seq_EML_Mouse0.84826341
78* GATA3_26560356_Chip-Seq_TH2_Human0.82978208
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82645855
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.78334026
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77944221
82KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.76182279
83CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.74346302
84KDM2B_26808549_Chip-Seq_DND41_Human0.73847426
85MYC_19079543_ChIP-ChIP_MESCs_Mouse0.73475376
86BCL6_27268052_Chip-Seq_Bcells_Human0.72978485
87TP63_19390658_ChIP-ChIP_HaCaT_Human0.72799862
88BCOR_27268052_Chip-Seq_Bcells_Human0.70847352
89SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70662599
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.70530580
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.69117228
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.68405768
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.68367247
94MYC_19030024_ChIP-ChIP_MESCs_Mouse0.68051905
95ETS1_20019798_ChIP-Seq_JURKAT_Human0.67330789
96EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.66643224
97BRD4_27068464_Chip-Seq_AML-cells_Mouse0.65853997
98ELF1_20517297_ChIP-Seq_JURKAT_Human0.64561703
99MYC_18940864_ChIP-ChIP_HL60_Human0.64425041
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.64188491

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.46293495
2MP0001835_abnormal_antigen_presentation4.20627499
3MP0001986_abnormal_taste_sensitivity3.60151847
4MP0001800_abnormal_humoral_immune3.55890978
5MP0001790_abnormal_immune_system3.47108410
6MP0005387_immune_system_phenotype3.47108410
7MP0003763_abnormal_thymus_physiology3.20717571
8MP0010094_abnormal_chromosome_stability3.04475806
9MP0000685_abnormal_immune_system2.99110080
10MP0002452_abnormal_antigen_presenting2.90251543
11MP0005000_abnormal_immune_tolerance2.75119407
12MP0003303_peritoneal_inflammation2.65321047
13MP0000569_abnormal_digit_pigmentation2.59148236
14MP0002398_abnormal_bone_marrow2.52858955
15MP0002723_abnormal_immune_serum2.52248917
16MP0002420_abnormal_adaptive_immunity2.51558032
17MP0001819_abnormal_immune_cell2.46061472
18MP0002138_abnormal_hepatobiliary_system2.25857490
19MP0005423_abnormal_somatic_nervous2.24473747
20MP0002009_preneoplasia2.24176080
21MP0000689_abnormal_spleen_morphology2.22241871
22MP0000716_abnormal_immune_system2.18460145
23MP0004808_abnormal_hematopoietic_stem1.96046078
24MP0002166_altered_tumor_susceptibility1.89649304
25MP0005671_abnormal_response_to1.87678878
26MP0002722_abnormal_immune_system1.83951861
27MP0002429_abnormal_blood_cell1.80949468
28MP0003111_abnormal_nucleus_morphology1.79727931
29MP0000703_abnormal_thymus_morphology1.77278074
30MP0000465_gastrointestinal_hemorrhage1.75065721
31MP0005075_abnormal_melanosome_morpholog1.73334163
32MP0003077_abnormal_cell_cycle1.73154446
33MP0001873_stomach_inflammation1.64097453
34MP0009785_altered_susceptibility_to1.63592428
35MP0002396_abnormal_hematopoietic_system1.61162718
36MP0002653_abnormal_ependyma_morphology1.59869688
37MP0008058_abnormal_DNA_repair1.57168423
38MP0005310_abnormal_salivary_gland1.55832636
39MP0004381_abnormal_hair_follicle1.51205474
40MP0008877_abnormal_DNA_methylation1.47011821
41MP0003436_decreased_susceptibility_to1.46119367
42MP0002405_respiratory_system_inflammati1.44221121
43MP0005025_abnormal_response_to1.43472466
44MP0003787_abnormal_imprinting1.42287170
45MP0000015_abnormal_ear_pigmentation1.39886740
46MP0000371_diluted_coat_color1.37561066
47MP0002148_abnormal_hypersensitivity_rea1.35101990
48MP0010234_abnormal_vibrissa_follicle1.34860365
49MP0001661_extended_life_span1.32809299
50MP0001853_heart_inflammation1.32642485
51MP0000490_abnormal_crypts_of1.30383974
52MP0008961_abnormal_basal_metabolism1.26869313
53MP0005464_abnormal_platelet_physiology1.26056254
54MP0002006_tumorigenesis1.23939142
55MP0002419_abnormal_innate_immunity1.23823549
56MP0002019_abnormal_tumor_incidence1.23764291
57MP0010155_abnormal_intestine_physiology1.22594962
58MP0001845_abnormal_inflammatory_respons1.18561998
59MP0000372_irregular_coat_pigmentation1.16347318
60MP0004272_abnormal_basement_membrane1.15417573
61MP0000313_abnormal_cell_death1.12489378
62MP0004957_abnormal_blastocyst_morpholog1.07562790
63MP0003172_abnormal_lysosome_physiology1.07297061
64MP0002132_abnormal_respiratory_system1.05072657
65MP0005379_endocrine/exocrine_gland_phen0.98274818
66MP0002332_abnormal_exercise_endurance0.95862060
67MP0005266_abnormal_metabolism0.94428583
68MP0009333_abnormal_splenocyte_physiolog0.94015539
69MP0005645_abnormal_hypothalamus_physiol0.93073699
70MP0010678_abnormal_skin_adnexa0.90205095
71MP0003693_abnormal_embryo_hatching0.89525907
72MP0000350_abnormal_cell_proliferation0.82087282
73MP0005397_hematopoietic_system_phenotyp0.80740740
74MP0001545_abnormal_hematopoietic_system0.80740740
75MP0008007_abnormal_cellular_replicative0.79802842
76MP0001730_embryonic_growth_arrest0.79623175
77MP0003045_fibrosis0.78873538
78MP0004947_skin_inflammation0.77163408
79MP0000383_abnormal_hair_follicle0.75202722
80MP0009278_abnormal_bone_marrow0.73239582
81MP0003786_premature_aging0.72416505
82MP0005451_abnormal_body_composition0.70754987
83MP0002075_abnormal_coat/hair_pigmentati0.70284730
84MP0001186_pigmentation_phenotype0.69463907
85MP0005621_abnormal_cell_physiology0.69383988
86MP0002877_abnormal_melanocyte_morpholog0.69129331
87MP0002822_catalepsy0.67674815
88MP0001663_abnormal_digestive_system0.67219421
89MP0002136_abnormal_kidney_physiology0.64077262
90MP0008469_abnormal_protein_level0.62700818
91MP0003300_gastrointestinal_ulcer0.59893898
92MP0005076_abnormal_cell_differentiation0.57010994
93MP0005501_abnormal_skin_physiology0.56821145
94MP0002095_abnormal_skin_pigmentation0.53949010
95MP0005220_abnormal_exocrine_pancreas0.52708253
96MP0005332_abnormal_amino_acid0.50417569
97MP0009115_abnormal_fat_cell0.49950944
98MP0001929_abnormal_gametogenesis0.49686684
99MP0009763_increased_sensitivity_to0.48592845
100MP0000249_abnormal_blood_vessel0.47967711

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)7.99019188
2Agammaglobulinemia (HP:0004432)7.37035436
3Calf muscle hypertrophy (HP:0008981)7.31610440
4Type II lissencephaly (HP:0007260)6.67961368
5Muscle hypertrophy of the lower extremities (HP:0008968)6.43886147
6Retinal dysplasia (HP:0007973)5.56467559
7Poikiloderma (HP:0001029)5.13921513
8Lymphopenia (HP:0001888)4.71368919
9Panhypogammaglobulinemia (HP:0003139)4.64593060
10Meningitis (HP:0001287)4.63835148
11Papilloma (HP:0012740)4.34826051
12Verrucae (HP:0200043)4.34826051
13Vasculitis (HP:0002633)4.28067696
14Recurrent sinusitis (HP:0011108)4.17230909
15Emphysema (HP:0002097)4.13955645
16Abnormality of cells of the lymphoid lineage (HP:0012140)4.12904069
17Cellulitis (HP:0100658)4.10475894
18Abnormality of DNA repair (HP:0003254)3.99830945
19Colitis (HP:0002583)3.92282713
20Recurrent viral infections (HP:0004429)3.73469329
21Recurrent bronchitis (HP:0002837)3.60963915
22Osteomyelitis (HP:0002754)3.56359575
23Lymphoma (HP:0002665)3.54981397
24Gastrointestinal inflammation (HP:0004386)3.54124349
25Restrictive lung disease (HP:0002091)3.52163999
26Inflammation of the large intestine (HP:0002037)3.49790643
27Entropion (HP:0000621)3.46993316
28Mediastinal lymphadenopathy (HP:0100721)3.45760253
29B lymphocytopenia (HP:0010976)3.36397875
30Severe combined immunodeficiency (HP:0004430)3.28600148
31Abnormality of B cell number (HP:0010975)3.17233134
32Hypoplasia of the thymus (HP:0000778)3.13424439
33Combined immunodeficiency (HP:0005387)3.10936506
34Abnormal delayed hypersensitivity skin test (HP:0002963)3.08863871
35T lymphocytopenia (HP:0005403)2.99861929
36Sepsis (HP:0100806)2.92225829
37Leukopenia (HP:0001882)2.89596373
38IgG deficiency (HP:0004315)2.83193515
39Recurrent pneumonia (HP:0006532)2.82661148
40Recurrent otitis media (HP:0000403)2.71400016
41Abnormality of the calf musculature (HP:0001430)2.69910981
42Chronic sinusitis (HP:0011109)2.68175186
43Chronic mucocutaneous candidiasis (HP:0002728)2.66826212
44Recurrent cutaneous fungal infections (HP:0011370)2.66826212
45Thyroiditis (HP:0100646)2.66422049
46Transposition of the great arteries (HP:0001669)2.61813708
47Abnormal connection of the cardiac segments (HP:0011545)2.61813708
48Abnormal ventriculo-arterial connection (HP:0011563)2.61813708
49Spinal rigidity (HP:0003306)2.60252491
50Recurrent lower respiratory tract infections (HP:0002783)2.51690817
51Viral hepatitis (HP:0006562)2.51498519
52Encephalitis (HP:0002383)2.50445930
53Abnormality of T cell number (HP:0011839)2.49398857
54Albinism (HP:0001022)2.48555546
55Recurrent fungal infections (HP:0002841)2.45961342
56Lissencephaly (HP:0001339)2.44452035
57Basal cell carcinoma (HP:0002671)2.23580798
58Deep palmar crease (HP:0006191)2.22965041
59Abnormality of T cells (HP:0002843)2.22866523
60Recurrent bacterial skin infections (HP:0005406)2.15791574
61Morphological abnormality of the pyramidal tract (HP:0002062)2.14805463
62Aplasia/Hypoplasia of the thymus (HP:0010515)2.14327238
63Abnormality of the fingertips (HP:0001211)2.12906527
64Recurrent abscess formation (HP:0002722)2.09688265
65Porencephaly (HP:0002132)2.09528496
66Muscular dystrophy (HP:0003560)2.09150486
67Abnormality of the prostate (HP:0008775)2.07528464
68Spontaneous hematomas (HP:0007420)2.05713389
69Ketoacidosis (HP:0001993)2.05469374
70Obstructive lung disease (HP:0006536)2.05370246
71Chronic obstructive pulmonary disease (HP:0006510)2.05370246
72Meningocele (HP:0002435)2.04514510
73IgM deficiency (HP:0002850)2.03456104
74Abnormality of T cell physiology (HP:0011840)2.02531259
75Abnormality of the peritoneum (HP:0002585)1.97882746
76Abnormality of chromosome stability (HP:0003220)1.97838875
77Hypoplasia of the brainstem (HP:0002365)1.97592338
78Aplasia/Hypoplasia of the brainstem (HP:0007362)1.97592338
79Posterior subcapsular cataract (HP:0007787)1.95553078
80Facial hemangioma (HP:0000329)1.90426371
81Abnormality of the vitreous humor (HP:0004327)1.89501955
82Bronchitis (HP:0012387)1.87254047
83Lip pit (HP:0100267)1.85608297
84Metaphyseal dysplasia (HP:0100255)1.84083590
85Abnormality of the pleura (HP:0002103)1.83972124
86Keratitis (HP:0000491)1.83471592
87Skin rash (HP:0000988)1.83271286
88Recurrent skin infections (HP:0001581)1.78576930
89Abnormality of the thymus (HP:0000777)1.75272151
90Gowers sign (HP:0003391)1.72486709
91Neutropenia (HP:0001875)1.69160051
92Dehydration (HP:0001944)1.68105784
93Prominent nose (HP:0000448)1.65482121
94Optic neuritis (HP:0100653)1.65202714
95Retrobulbar optic neuritis (HP:0100654)1.65202714
96Clubbing of toes (HP:0100760)1.65162615
97Epiphyseal dysplasia (HP:0002656)1.64563458
98Chromosomal breakage induced by crosslinking agents (HP:0003221)1.63088962
99Sparse lateral eyebrow (HP:0005338)1.60878127
100Chromsome breakage (HP:0040012)1.60143626

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK198.13675495
2MAP3K107.11257943
3MAP4K13.59741243
4ERN13.06123903
5MAP3K132.62847130
6BLK2.52027415
7ARAF2.28839701
8BTK2.03852265
9TEC1.98751318
10SYK1.98009118
11RIPK41.97269612
12MAP3K91.87521291
13SIK31.73297710
14ICK1.63843333
15CDK41.56817882
16IRAK41.56432179
17MST41.55315035
18BRD41.54154980
19BMPR21.46449534
20MAPK111.43542313
21PIK3CG1.38847260
22CDK81.24136196
23CDK121.23453595
24ITK1.22980700
25LYN1.22810763
26PRPF4B1.15082487
27CSF1R1.02511621
28RPS6KB11.02459530
29BRAF1.01186738
30SMG10.99579900
31TRIB30.94469607
32GRK60.94457916
33IKBKB0.93489659
34MARK20.92164286
35EEF2K0.89687305
36FES0.84143053
37KSR20.82646646
38ATR0.78282004
39TESK20.76485385
40NLK0.72594287
41MAPK70.65002787
42EIF2AK30.62064197
43KSR10.60451114
44EIF2AK20.60292612
45CDK90.60102898
46RAF10.58978989
47HCK0.58848439
48CDC70.57648246
49MAP4K20.56725033
50PDK10.55230678
51TRIM280.54577381
52BMPR1B0.53223295
53CHEK10.52210339
54PASK0.51997879
55RPS6KB20.51424596
56PIM10.51252004
57MAP3K140.49016942
58CHUK0.47903509
59NME20.47490585
60CDK70.45968079
61CCNB10.45874145
62VRK20.45391339
63MAPK40.43734249
64SIK20.43709982
65MELK0.42005770
66PRKCQ0.41254549
67MAP3K80.40793953
68RPS6KA40.39263987
69DYRK30.38323725
70TYK20.38221776
71ABL10.37826330
72AURKB0.37581401
73IKBKE0.37225217
74MAP2K60.36970305
75STK100.36769100
76TXK0.36150610
77MARK30.36127783
78TNK20.34025020
79TGFBR10.33076348
80ATM0.32703392
81MAPK120.32681406
82STK30.32431147
83MAPK30.31838435
84CDK30.31588147
85MOS0.31220538
86CDK20.31049228
87MAP2K20.30562308
88PDPK10.28988123
89CDK60.28563634
90CDC42BPA0.28465068
91BRSK20.28018957
92MAPK10.27593948
93DYRK1B0.26213930
94TLK10.25252794
95JAK10.25040977
96RPS6KC10.24832729
97RPS6KL10.24832729
98LCK0.24496024
99MAPKAPK20.24485188
100MAP2K30.22493431

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046624.09144937
2Primary immunodeficiency_Homo sapiens_hsa053403.82263617
3Asthma_Homo sapiens_hsa053103.69852002
4Pentose phosphate pathway_Homo sapiens_hsa000303.45511619
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.38032286
6Allograft rejection_Homo sapiens_hsa053303.07479712
7Autoimmune thyroid disease_Homo sapiens_hsa053202.97857159
8Graft-versus-host disease_Homo sapiens_hsa053322.78889334
9Type I diabetes mellitus_Homo sapiens_hsa049402.44084664
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.18356706
11Non-homologous end-joining_Homo sapiens_hsa034502.14461067
12DNA replication_Homo sapiens_hsa030302.00647748
13Hematopoietic cell lineage_Homo sapiens_hsa046401.98814964
14Leishmaniasis_Homo sapiens_hsa051401.98428723
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.88569097
16Antigen processing and presentation_Homo sapiens_hsa046121.83909708
17Staphylococcus aureus infection_Homo sapiens_hsa051501.81369582
18mRNA surveillance pathway_Homo sapiens_hsa030151.70982200
19Viral myocarditis_Homo sapiens_hsa054161.69652142
20Herpes simplex infection_Homo sapiens_hsa051681.67738310
21Notch signaling pathway_Homo sapiens_hsa043301.63941359
22Toxoplasmosis_Homo sapiens_hsa051451.55581520
23Epstein-Barr virus infection_Homo sapiens_hsa051691.47088256
24Cell cycle_Homo sapiens_hsa041101.44718170
25Mismatch repair_Homo sapiens_hsa034301.43238372
26Influenza A_Homo sapiens_hsa051641.36628896
27Tuberculosis_Homo sapiens_hsa051521.35879614
28Non-small cell lung cancer_Homo sapiens_hsa052231.29560538
29Hepatitis B_Homo sapiens_hsa051611.27694592
30Base excision repair_Homo sapiens_hsa034101.25390316
31Osteoclast differentiation_Homo sapiens_hsa043801.25195737
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21577432
33HTLV-I infection_Homo sapiens_hsa051661.18673225
34Nucleotide excision repair_Homo sapiens_hsa034201.15662627
35Systemic lupus erythematosus_Homo sapiens_hsa053221.04169297
36Chronic myeloid leukemia_Homo sapiens_hsa052201.03949592
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.98345936
38Viral carcinogenesis_Homo sapiens_hsa052030.97641941
39T cell receptor signaling pathway_Homo sapiens_hsa046600.97434592
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95808914
41RNA polymerase_Homo sapiens_hsa030200.92407029
42Prostate cancer_Homo sapiens_hsa052150.92040255
43Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91071423
44Spliceosome_Homo sapiens_hsa030400.90911045
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88349951
46Apoptosis_Homo sapiens_hsa042100.88109267
47RNA transport_Homo sapiens_hsa030130.86058361
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85931527
49Fanconi anemia pathway_Homo sapiens_hsa034600.85846692
50Homologous recombination_Homo sapiens_hsa034400.85155937
51Rheumatoid arthritis_Homo sapiens_hsa053230.83805359
52Bladder cancer_Homo sapiens_hsa052190.79041117
53Glioma_Homo sapiens_hsa052140.74974361
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73803368
55One carbon pool by folate_Homo sapiens_hsa006700.73700398
56Pancreatic cancer_Homo sapiens_hsa052120.72764816
57Acute myeloid leukemia_Homo sapiens_hsa052210.72568978
58Colorectal cancer_Homo sapiens_hsa052100.71506280
59Small cell lung cancer_Homo sapiens_hsa052220.70548483
60Pyrimidine metabolism_Homo sapiens_hsa002400.69157624
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.67263290
62Measles_Homo sapiens_hsa051620.64584753
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61464545
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60901503
65RNA degradation_Homo sapiens_hsa030180.60807447
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.60100144
67Biosynthesis of amino acids_Homo sapiens_hsa012300.59586539
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.57925010
69Renal cell carcinoma_Homo sapiens_hsa052110.56230623
70p53 signaling pathway_Homo sapiens_hsa041150.54906922
71Platelet activation_Homo sapiens_hsa046110.51583281
72mTOR signaling pathway_Homo sapiens_hsa041500.51428508
73MicroRNAs in cancer_Homo sapiens_hsa052060.51014838
74Lysine degradation_Homo sapiens_hsa003100.49996208
75Phagosome_Homo sapiens_hsa041450.49489639
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49152347
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47461134
78Oocyte meiosis_Homo sapiens_hsa041140.47273796
79FoxO signaling pathway_Homo sapiens_hsa040680.42565888
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38282057
81Alcoholism_Homo sapiens_hsa050340.35636275
82Legionellosis_Homo sapiens_hsa051340.35110892
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34895260
84Butanoate metabolism_Homo sapiens_hsa006500.33715596
85Basal transcription factors_Homo sapiens_hsa030220.33498228
86Hepatitis C_Homo sapiens_hsa051600.33252456
87Endometrial cancer_Homo sapiens_hsa052130.32559163
88TNF signaling pathway_Homo sapiens_hsa046680.30712703
89Chemokine signaling pathway_Homo sapiens_hsa040620.29476032
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29418432
91Melanoma_Homo sapiens_hsa052180.28849705
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26796579
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.26432751
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24739259
95Choline metabolism in cancer_Homo sapiens_hsa052310.23895298
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22328998
97Pertussis_Homo sapiens_hsa051330.21814230
98AMPK signaling pathway_Homo sapiens_hsa041520.21209481
99VEGF signaling pathway_Homo sapiens_hsa043700.20669770
100Thyroid cancer_Homo sapiens_hsa052160.20361200

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