ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	postsynaptic membrane organization (GO:0001941)	5.25687445
2	synaptic vesicle maturation (GO:0016188)	5.11571603
3	regulation of synaptic vesicle exocytosis (GO:2000300)	4.75656587
4	pyrimidine nucleobase catabolic process (GO:0006208)	4.69727253
5	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	4.56442918
6	synaptic vesicle docking involved in exocytosis (GO:0016081)	4.55903415
7	glutamate secretion (GO:0014047)	4.10399819
8	cellular response to leptin stimulus (GO:0044320)	4.10088228
9	locomotory exploration behavior (GO:0035641)	4.08114885
10	regulation of synaptic vesicle transport (GO:1902803)	4.05500344
11	nucleobase catabolic process (GO:0046113)	4.01428893
12	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.96883606
13	sodium ion export (GO:0071436)	3.91974795
14	synaptic vesicle exocytosis (GO:0016079)	3.88650589
15	neuron cell-cell adhesion (GO:0007158)	3.85570885
16	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.78766013
17	neuronal action potential propagation (GO:0019227)	3.78450673
18	nonmotile primary cilium assembly (GO:0035058)	3.74445733
19	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.72483938
20	cell communication by electrical coupling (GO:0010644)	3.65881682
21	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.63632999
22	cellular potassium ion homeostasis (GO:0030007)	3.63412432
23	axonal fasciculation (GO:0007413)	3.54236514
24	response to leptin (GO:0044321)	3.52193652
25	vocalization behavior (GO:0071625)	3.50362830
26	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.48937513
27	regulation of respiratory system process (GO:0044065)	3.48551206
28	protein localization to synapse (GO:0035418)	3.46579295
29	cerebellar granule cell differentiation (GO:0021707)	3.46314218
30	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.43938000
31	establishment of mitochondrion localization (GO:0051654)	3.40772893
32	synaptic vesicle endocytosis (GO:0048488)	3.36776837
33	presynaptic membrane assembly (GO:0097105)	3.36310902
34	exploration behavior (GO:0035640)	3.35352335
35	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	3.34107673
36	synaptic transmission, glutamatergic (GO:0035249)	3.33731107
37	striatum development (GO:0021756)	3.32672004
38	neuromuscular synaptic transmission (GO:0007274)	3.32431107
39	neuron recognition (GO:0008038)	3.20829447
40	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.15397496
41	gamma-aminobutyric acid transport (GO:0015812)	3.13771986
42	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	3.13635123
43	cell migration in hindbrain (GO:0021535)	3.13505582
44	layer formation in cerebral cortex (GO:0021819)	3.10174074
45	glial cell proliferation (GO:0014009)	3.06550860
46	neurotransmitter secretion (GO:0007269)	3.04809210
47	neuronal ion channel clustering (GO:0045161)	3.04676543
48	regulation of cilium movement (GO:0003352)	3.04474259
49	presynaptic membrane organization (GO:0097090)	3.03409956
50	regulation of neuronal synaptic plasticity (GO:0048168)	3.00911446
51	regulation of voltage-gated calcium channel activity (GO:1901385)	3.00454672
52	regulation of synapse structural plasticity (GO:0051823)	2.95725786
53	regulation of actin filament-based movement (GO:1903115)	2.94824641
54	neuron-neuron synaptic transmission (GO:0007270)	2.94625160
55	response to gravity (GO:0009629)	2.94042439
56	regulation of cell communication by electrical coupling (GO:0010649)	2.93998782
57	cell communication involved in cardiac conduction (GO:0086065)	2.89864907
58	regulation of cardiac muscle cell contraction (GO:0086004)	2.88373872
59	regulation of neurotransmitter secretion (GO:0046928)	2.87491579
60	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.86264792
61	regulation of respiratory gaseous exchange (GO:0043576)	2.85904187
62	startle response (GO:0001964)	2.85374479
63	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.85189197
64	alpha-linolenic acid metabolic process (GO:0036109)	2.85046188
65	membrane depolarization during action potential (GO:0086010)	2.84999514
66	synapse assembly (GO:0007416)	2.83033810
67	L-amino acid import (GO:0043092)	2.82818630
68	negative regulation of appetite (GO:0032099)	2.79580198
69	negative regulation of response to food (GO:0032096)	2.79580198
70	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	2.78952358
71	dendritic spine morphogenesis (GO:0060997)	2.78421241
72	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.78145025
73	glutamate receptor signaling pathway (GO:0007215)	2.73999588
74	positive regulation of synapse maturation (GO:0090129)	2.72650860
75	regulation of neurotransmitter transport (GO:0051588)	2.71647607
76	synapse organization (GO:0050808)	2.69425279
77	neurotransmitter uptake (GO:0001504)	2.69122955
78	amino acid import (GO:0043090)	2.67703492
79	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	2.66691396
80	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	2.66549844
81	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.66356335
82	dendrite morphogenesis (GO:0048813)	2.66075133
83	cerebral cortex radially oriented cell migration (GO:0021799)	2.65865288
84	cellular sodium ion homeostasis (GO:0006883)	2.63164362
85	head development (GO:0060322)	2.62872259
86	proline transport (GO:0015824)	2.61932364
87	activation of protein kinase A activity (GO:0034199)	2.61495393
88	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	2.59076204
89	sequestering of actin monomers (GO:0042989)	2.57636498
90	neurotransmitter transport (GO:0006836)	2.56796647
91	sarcoplasmic reticulum calcium ion transport (GO:0070296)	2.56019413
92	positive regulation of mitochondrial fission (GO:0090141)	2.55768067
93	regulation of neurotransmitter levels (GO:0001505)	2.55438421
94	C4-dicarboxylate transport (GO:0015740)	2.54434709
95	brain morphogenesis (GO:0048854)	2.54348535
96	neuromuscular junction development (GO:0007528)	2.53206512
97	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.52574845
98	linoleic acid metabolic process (GO:0043651)	2.52360792
99	neurotransmitter-gated ion channel clustering (GO:0072578)	2.51283464
100	auditory behavior (GO:0031223)	2.50507839

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.18577820
2	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	4.02137799
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.56042004
4	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.73795469
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.68774372
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.56049779
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.54860580
8	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.47362619
9	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.34008790
10	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.21070329
11	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.14301197
12	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.12923314
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.11522203
14	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.08019749
15	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.08019749
16	RARB_27405468_Chip-Seq_BRAIN_Mouse	2.07604213
17	REST_18959480_ChIP-ChIP_MESCs_Mouse	2.04424706
18	TAF15_26573619_Chip-Seq_HEK293_Human	2.02992276
19	DROSHA_22980978_ChIP-Seq_HELA_Human	2.02572615
20	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.02170023
21	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.99255384
22	REST_21632747_ChIP-Seq_MESCs_Mouse	1.97595936
23	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.97214431
24	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.95542867
25	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.91779161
26	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.90795357
27	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.89298221
28	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.88862711
29	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.87915625
30	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.78099809
31	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.77631061
32	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.69685626
33	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.64989371
34	RNF2_27304074_Chip-Seq_NSC_Mouse	1.57360144
35	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.56073320
36	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.54638902
37	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.51464037
38	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.47936768
39	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.46116527
40	AR_21572438_ChIP-Seq_LNCaP_Human	1.41819842
41	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.38129339
42	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.35613790
43	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.34320714
44	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.33506118
45	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.31902708
46	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.31378946
47	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.30558828
48	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.29243008
49	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.29163589
50	SMAD4_21799915_ChIP-Seq_A2780_Human	1.28695277
51	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.27839437
52	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.22129156
53	AR_19668381_ChIP-Seq_PC3_Human	1.21786844
54	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.21436127
55	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.20030058
56	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.19999074
57	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.18784300
58	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.17972608
59	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.17161342
60	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.16551203
61	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.15687528
62	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.15489559
63	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.14979412
64	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.11523794
65	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.08947488
66	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.08293699
67	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.07555259
68	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.05013437
69	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.04930949
70	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03549237
71	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.02979201
72	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.01220303
73	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.96872755
74	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.95748865
75	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.95528804
76	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.94943962
77	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.94863951
78	CBP_20019798_ChIP-Seq_JUKART_Human	0.94863951
79	STAT3_23295773_ChIP-Seq_U87_Human	0.94213296
80	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.94069287
81	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.93888210
82	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.93322654
83	ISL1_27105846_Chip-Seq_CPCs_Mouse	0.92630462
84	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.92276429
85	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.91571076
86	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.90260374
87	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	0.88857411
88	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.88467506
89	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.87408032
90	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.87064418
91	SOX9_26525672_Chip-Seq_HEART_Mouse	0.86760584
92	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.86284373
93	CTCF_27219007_Chip-Seq_Bcells_Human	0.85981134
94	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.85661502
95	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.82103536
96	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.81576296
97	AR_25329375_ChIP-Seq_VCAP_Human	0.80813251
98	TCF4_23295773_ChIP-Seq_U87_Human	0.80701403
99	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.79863782
100	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.79829108

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	4.45814888
2	MP0005423_abnormal_somatic_nervous	4.35863921
3	MP0004270_analgesia	3.99161405
4	MP0003880_abnormal_central_pattern	3.92664643
5	MP0001984_abnormal_olfaction	3.21530639
6	MP0002822_catalepsy	3.00866318
7	MP0000751_myopathy	2.91231671
8	MP0003635_abnormal_synaptic_transmissio	2.65436729
9	MP0005394_taste/olfaction_phenotype	2.53118585
10	MP0005499_abnormal_olfactory_system	2.53118585
11	MP0002734_abnormal_mechanical_nocicepti	2.49756389
12	MP0001486_abnormal_startle_reflex	2.38456130
13	MP0008789_abnormal_olfactory_epithelium	2.38215517
14	MP0001968_abnormal_touch/_nociception	2.38016016
15	MP0002063_abnormal_learning/memory/cond	2.25727073
16	MP0001529_abnormal_vocalization	2.25701032
17	MP0002736_abnormal_nociception_after	2.11061624
18	MP0000778_abnormal_nervous_system	2.06502454
19	MP0002572_abnormal_emotion/affect_behav	2.05610557
20	MP0002064_seizures	1.98125452
21	MP0002272_abnormal_nervous_system	1.92377101
22	MP0009745_abnormal_behavioral_response	1.88198937
23	MP0003122_maternal_imprinting	1.87124709
24	MP0002735_abnormal_chemical_nociception	1.72827150
25	MP0002102_abnormal_ear_morphology	1.72467109
26	MP0009046_muscle_twitch	1.58871551
27	MP0000749_muscle_degeneration	1.54814536
28	MP0002249_abnormal_larynx_morphology	1.54409418
29	MP0001970_abnormal_pain_threshold	1.50883901
30	MP0005171_absent_coat_pigmentation	1.47838593
31	MP0004811_abnormal_neuron_physiology	1.45060177
32	MP0003329_amyloid_beta_deposits	1.43284079
33	MP0002557_abnormal_social/conspecific_i	1.41110407
34	MP0002184_abnormal_innervation	1.40086338
35	MP0003938_abnormal_ear_development	1.32686515
36	MP0008569_lethality_at_weaning	1.31401380
37	MP0000049_abnormal_middle_ear	1.31400788
38	MP0002733_abnormal_thermal_nociception	1.28098630
39	MP0002067_abnormal_sensory_capabilities	1.26824968
40	MP0004145_abnormal_muscle_electrophysio	1.24076510
41	MP0000955_abnormal_spinal_cord	1.23653669
42	MP0006276_abnormal_autonomic_nervous	1.22381134
43	MP0002882_abnormal_neuron_morphology	1.21633648
44	MP0001502_abnormal_circadian_rhythm	1.19808592
45	MP0004924_abnormal_behavior	1.19778453
46	MP0005386_behavior/neurological_phenoty	1.19778453
47	MP0004036_abnormal_muscle_relaxation	1.19378624
48	MP0001299_abnormal_eye_distance/	1.18719978
49	MP0002066_abnormal_motor_capabilities/c	1.17847890
50	MP0004885_abnormal_endolymph	1.17245434
51	MP0001905_abnormal_dopamine_level	1.15863661
52	MP0002233_abnormal_nose_morphology	1.11398844
53	MP0002909_abnormal_adrenal_gland	1.09172193
54	MP0004215_abnormal_myocardial_fiber	1.08067928
55	MP0001440_abnormal_grooming_behavior	1.07449679
56	MP0002152_abnormal_brain_morphology	1.07418075
57	MP0005253_abnormal_eye_physiology	1.04041687
58	MP0000747_muscle_weakness	1.03382750
59	MP0000026_abnormal_inner_ear	1.02393700
60	MP0003137_abnormal_impulse_conducting	0.99488648
61	MP0001177_atelectasis	0.98922349
62	MP0000013_abnormal_adipose_tissue	0.98044964
63	MP0005551_abnormal_eye_electrophysiolog	0.95507212
64	MP0001485_abnormal_pinna_reflex	0.94703273
65	MP0001958_emphysema	0.93229589
66	MP0000759_abnormal_skeletal_muscle	0.93032341
67	MP0003646_muscle_fatigue	0.92291191
68	MP0003690_abnormal_glial_cell	0.90546622
69	MP0005620_abnormal_muscle_contractility	0.88458500
70	MP0002638_abnormal_pupillary_reflex	0.86113963
71	MP0003879_abnormal_hair_cell	0.85106977
72	MP0002069_abnormal_eating/drinking_beha	0.84955202
73	MP0003634_abnormal_glial_cell	0.84771180
74	MP0004130_abnormal_muscle_cell	0.84592438
75	MP0004742_abnormal_vestibular_system	0.84505449
76	MP0001963_abnormal_hearing_physiology	0.84386413
77	MP0005377_hearing/vestibular/ear_phenot	0.83177130
78	MP0003878_abnormal_ear_physiology	0.83177130
79	MP0005503_abnormal_tendon_morphology	0.82464123
80	MP0005369_muscle_phenotype	0.81832597
81	MP0002752_abnormal_somatic_nervous	0.81724453
82	MP0002106_abnormal_muscle_physiology	0.80525790
83	MP0003385_abnormal_body_wall	0.80192918
84	MP0005645_abnormal_hypothalamus_physiol	0.80186425
85	MP0003633_abnormal_nervous_system	0.79760085
86	MP0003861_abnormal_nervous_system	0.79345940
87	MP0008260_abnormal_autophagy	0.78549973
88	MP0004087_abnormal_muscle_fiber	0.78275824
89	MP0001943_abnormal_respiration	0.75682512
90	MP0004142_abnormal_muscle_tone	0.72557593
91	MP0005248_abnormal_Harderian_gland	0.72253966
92	MP0002751_abnormal_autonomic_nervous	0.71433969
93	MP0002108_abnormal_muscle_morphology	0.70152168
94	MP0009780_abnormal_chondrocyte_physiolo	0.69773616
95	MP0003115_abnormal_respiratory_system	0.69148477
96	MP0004084_abnormal_cardiac_muscle	0.67324202
97	MP0001501_abnormal_sleep_pattern	0.67148837
98	MP0004858_abnormal_nervous_system	0.66769882
99	MP0000920_abnormal_myelination	0.66066314
100	MP0003136_yellow_coat_color	0.65636790

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	4.74690602
2	Action tremor (HP:0002345)	3.83409451
3	Myokymia (HP:0002411)	3.80288766
4	Exercise-induced muscle cramps (HP:0003710)	3.63540241
5	Split foot (HP:0001839)	3.54512336
6	Fetal akinesia sequence (HP:0001989)	3.22612994
7	Focal seizures (HP:0007359)	3.18325765
8	Gait imbalance (HP:0002141)	3.03331998
9	Rimmed vacuoles (HP:0003805)	2.96413346
10	Vertebral arch anomaly (HP:0008438)	2.95762967
11	Muscle fiber inclusion bodies (HP:0100299)	2.94199044
12	Exercise-induced myalgia (HP:0003738)	2.85685179
13	Nemaline bodies (HP:0003798)	2.82963364
14	Type 1 muscle fiber predominance (HP:0003803)	2.82148110
15	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	2.81278582
16	Myotonia (HP:0002486)	2.78992087
17	Long clavicles (HP:0000890)	2.65319558
18	Congenital primary aphakia (HP:0007707)	2.64905508
19	Febrile seizures (HP:0002373)	2.58563304
20	Generalized tonic-clonic seizures (HP:0002069)	2.53694367
21	Atonic seizures (HP:0010819)	2.52054083
22	Abnormality of the lower motor neuron (HP:0002366)	2.51628448
23	Epileptic encephalopathy (HP:0200134)	2.51443067
24	Ankle clonus (HP:0011448)	2.44984746
25	Spastic gait (HP:0002064)	2.41090010
26	Nuclear cataract (HP:0100018)	2.37880781
27	Difficulty running (HP:0009046)	2.36904268
28	Hemiplegia (HP:0002301)	2.31278767
29	Drooling (HP:0002307)	2.30070331
30	Abnormality of the corticospinal tract (HP:0002492)	2.29004390
31	Nephrogenic diabetes insipidus (HP:0009806)	2.23570734
32	Abnormal eating behavior (HP:0100738)	2.22135213
33	Papilledema (HP:0001085)	2.21328565
34	Poor eye contact (HP:0000817)	2.18915167
35	Urinary urgency (HP:0000012)	2.17269507
36	Turricephaly (HP:0000262)	2.17080151
37	Alacrima (HP:0000522)	2.15196192
38	Akinesia (HP:0002304)	2.13455307
39	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.13281812
40	Myopathic facies (HP:0002058)	2.10765052
41	Medial flaring of the eyebrow (HP:0010747)	2.10181200
42	Polyphagia (HP:0002591)	2.06194922
43	Excessive salivation (HP:0003781)	2.06080005
44	Vaginal atresia (HP:0000148)	2.04641896
45	EMG: neuropathic changes (HP:0003445)	2.04188686
46	Scanning speech (HP:0002168)	2.03243845
47	Muscle hypertrophy of the lower extremities (HP:0008968)	2.01108990
48	Hepatoblastoma (HP:0002884)	2.00324778
49	Genital tract atresia (HP:0001827)	1.99169535
50	Progressive cerebellar ataxia (HP:0002073)	1.98729620
51	Postural instability (HP:0002172)	1.98613348
52	Shoulder girdle muscle weakness (HP:0003547)	1.97208394
53	Abnormal social behavior (HP:0012433)	1.96743439
54	Impaired social interactions (HP:0000735)	1.96743439
55	Sudden death (HP:0001699)	1.94518048
56	Amblyopia (HP:0000646)	1.94205004
57	Torticollis (HP:0000473)	1.94149615
58	Sleep apnea (HP:0010535)	1.93832695
59	Epileptiform EEG discharges (HP:0011182)	1.91886793
60	Hemiparesis (HP:0001269)	1.90352398
61	Insidious onset (HP:0003587)	1.90158192
62	Termporal pattern (HP:0011008)	1.90158192
63	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.89371314
64	Calf muscle hypertrophy (HP:0008981)	1.89245785
65	Diplopia (HP:0000651)	1.87452479
66	Abnormality of binocular vision (HP:0011514)	1.87452479
67	Urinary bladder sphincter dysfunction (HP:0002839)	1.86997019
68	Lower limb muscle weakness (HP:0007340)	1.86657398
69	Aplasia/Hypoplasia of the lens (HP:0008063)	1.86559978
70	Cortical dysplasia (HP:0002539)	1.85944219
71	Specific learning disability (HP:0001328)	1.83826292
72	Broad-based gait (HP:0002136)	1.83177712
73	Obstructive sleep apnea (HP:0002870)	1.82750122
74	Abnormality of the hip-girdle musculature (HP:0001445)	1.82665545
75	Abnormality of the musculature of the pelvis (HP:0001469)	1.82665545
76	Agitation (HP:0000713)	1.82284861
77	Pheochromocytoma (HP:0002666)	1.81495011
78	Distal arthrogryposis (HP:0005684)	1.81351960
79	Poor coordination (HP:0002370)	1.80639516
80	Back pain (HP:0003418)	1.80191854
81	Tetraplegia (HP:0002445)	1.78476371
82	Depression (HP:0000716)	1.78437722
83	Abnormality of the aortic arch (HP:0012303)	1.76012056
84	Gonadotropin excess (HP:0000837)	1.75428401
85	Truncal ataxia (HP:0002078)	1.74576791
86	Annular pancreas (HP:0001734)	1.74324562
87	Abnormality of the calf musculature (HP:0001430)	1.73481958
88	Limb dystonia (HP:0002451)	1.72853013
89	EEG with generalized epileptiform discharges (HP:0011198)	1.71921533
90	Decreased lacrimation (HP:0000633)	1.71069012
91	Amyotrophic lateral sclerosis (HP:0007354)	1.70966130
92	Muscle fiber splitting (HP:0003555)	1.69907441
93	Limb-girdle muscle weakness (HP:0003325)	1.69350593
94	Left ventricular hypertrophy (HP:0001712)	1.68151340
95	Morphological abnormality of the middle ear (HP:0008609)	1.67971302
96	Hypsarrhythmia (HP:0002521)	1.67834320
97	Hypoplasia of the corpus callosum (HP:0002079)	1.66853458
98	Neoplasm of the heart (HP:0100544)	1.66806028
99	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.66440927
100	Impaired vibration sensation in the lower limbs (HP:0002166)	1.64192559

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA4	5.32737871
2	MARK1	3.92843238
3	CASK	2.86107033
4	MAP3K4	2.64635363
5	EPHA3	2.53625062
6	PAK6	2.51155041
7	NTRK2	2.19588120
8	BCR	2.18684929
9	OBSCN	2.15952887
10	MAP2K7	2.10521192
11	MAP4K2	1.94093885
12	CDK19	1.87913417
13	NTRK1	1.87103661
14	NTRK3	1.75572444
15	UHMK1	1.74506903
16	DAPK2	1.71173727
17	PINK1	1.70251853
18	PHKG1	1.69314451
19	PHKG2	1.69314451
20	PLK2	1.58361029
21	WNK3	1.51933267
22	MAP2K4	1.37340344
23	SGK223	1.36791130
24	SGK494	1.36791130
25	CSNK1G2	1.35021007
26	PAK3	1.32339755
27	SGK2	1.23984903
28	PRKD3	1.23663559
29	DYRK1B	1.22335334
30	TTN	1.20367181
31	CCNB1	1.17138808
32	MINK1	1.15893080
33	LIMK1	1.14906621
34	RIPK1	1.13272452
35	EPHB2	1.11837276
36	CDK5	1.09978733
37	CAMKK1	1.09895480
38	DYRK2	1.09473074
39	MAPK15	1.09451823
40	AKT3	1.08954388
41	SRPK1	1.05756148
42	MAPK13	1.05415272
43	PDGFRA	1.03247258
44	TNIK	1.00551124
45	CAMK2B	0.98987820
46	TRIM28	0.98800186
47	PRKCG	0.97144853
48	CSNK1A1L	0.94627865
49	CSNK1G3	0.87235072
50	LATS2	0.87085115
51	PKN1	0.85385380
52	SGK3	0.84461139
53	CSNK1G1	0.83998108
54	CDK18	0.83363256
55	CDK15	0.81436738
56	MAP3K7	0.81315661
57	CDK11A	0.79506016
58	CAMK2A	0.78792984
59	CDK14	0.78005975
60	MAP3K9	0.77415367
61	MAPK12	0.76059088
62	KSR2	0.75648219
63	CAMK2G	0.74770824
64	DYRK1A	0.68442582
65	TYRO3	0.64871102
66	CAMK1	0.64378225
67	EEF2K	0.62692644
68	DYRK3	0.62312609
69	MAPK11	0.61990584
70	MKNK1	0.60538617
71	RPS6KB1	0.60495619
72	ROCK2	0.60316913
73	CAMK4	0.59456908
74	MAPK10	0.57718917
75	DAPK1	0.57094235
76	KSR1	0.55584846
77	ICK	0.54104715
78	RET	0.53635173
79	STK38	0.52492506
80	AKT2	0.52193249
81	STK38L	0.51313103
82	SGK1	0.50751725
83	MUSK	0.50284622
84	IRAK2	0.49343580
85	PRKAA1	0.47889954
86	MARK2	0.47194905
87	RPS6KA4	0.47162468
88	RPS6KA3	0.46660216
89	SIK2	0.46416381
90	PRKCE	0.46104857
91	MAPKAPK3	0.45908329
92	NEK9	0.45564963
93	BCKDK	0.44245887
94	FER	0.43930447
95	TESK1	0.43753528
96	CAMKK2	0.43238488
97	BRSK1	0.43084207
98	CSNK1A1	0.42481684
99	NEK6	0.40805030
100	CSNK1D	0.39011259

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.51325898
2	GABAergic synapse_Homo sapiens_hsa04727	2.12767186
3	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.08952318
4	Circadian entrainment_Homo sapiens_hsa04713	2.07420175
5	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	2.03654900
6	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.03346501
7	Amphetamine addiction_Homo sapiens_hsa05031	1.85654787
8	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.85617184
9	Glutamatergic synapse_Homo sapiens_hsa04724	1.80731860
10	Long-term potentiation_Homo sapiens_hsa04720	1.72155967
11	Morphine addiction_Homo sapiens_hsa05032	1.68422303
12	Insulin secretion_Homo sapiens_hsa04911	1.65107193
13	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.64029638
14	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.62108764
15	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.60052649
16	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.58477562
17	Taste transduction_Homo sapiens_hsa04742	1.57391496
18	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.55270268
19	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.51963394
20	Dopaminergic synapse_Homo sapiens_hsa04728	1.47776382
21	Gastric acid secretion_Homo sapiens_hsa04971	1.46816618
22	Cocaine addiction_Homo sapiens_hsa05030	1.44121038
23	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.39515688
24	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.38977839
25	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.36504504
26	Calcium signaling pathway_Homo sapiens_hsa04020	1.33320931
27	Gap junction_Homo sapiens_hsa04540	1.32380819
28	Cholinergic synapse_Homo sapiens_hsa04725	1.29994474
29	Salivary secretion_Homo sapiens_hsa04970	1.28663263
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.26994431
31	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.25302141
32	cAMP signaling pathway_Homo sapiens_hsa04024	1.23908885
33	Circadian rhythm_Homo sapiens_hsa04710	1.21931804
34	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.20784954
35	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.19280009
36	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.18538290
37	Melanogenesis_Homo sapiens_hsa04916	1.17936802
38	Cardiac muscle contraction_Homo sapiens_hsa04260	1.15119399
39	Axon guidance_Homo sapiens_hsa04360	1.11589553
40	Bile secretion_Homo sapiens_hsa04976	1.10855333
41	beta-Alanine metabolism_Homo sapiens_hsa00410	1.10658723
42	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.04599887
43	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.04278711
44	Propanoate metabolism_Homo sapiens_hsa00640	1.00442207
45	Long-term depression_Homo sapiens_hsa04730	0.98055517
46	Fatty acid metabolism_Homo sapiens_hsa01212	0.94839171
47	Hippo signaling pathway_Homo sapiens_hsa04390	0.94578882
48	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.94063331
49	Oocyte meiosis_Homo sapiens_hsa04114	0.93475198
50	AMPK signaling pathway_Homo sapiens_hsa04152	0.91929962
51	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.91326806
52	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.90772886
53	Fatty acid elongation_Homo sapiens_hsa00062	0.88664168
54	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.87335299
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.86198183
56	Renin secretion_Homo sapiens_hsa04924	0.85218558
57	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.84720185
58	Glucagon signaling pathway_Homo sapiens_hsa04922	0.83998809
59	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.83273455
60	Arginine and proline metabolism_Homo sapiens_hsa00330	0.82075145
61	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.81913268
62	Basal cell carcinoma_Homo sapiens_hsa05217	0.80519981
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.73543155
64	Estrogen signaling pathway_Homo sapiens_hsa04915	0.73372312
65	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.72500429
66	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.72033498
67	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.71397748
68	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.69600884
69	Lysine degradation_Homo sapiens_hsa00310	0.68224905
70	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.68016584
71	GnRH signaling pathway_Homo sapiens_hsa04912	0.67831134
72	Carbon metabolism_Homo sapiens_hsa01200	0.66215787
73	Tight junction_Homo sapiens_hsa04530	0.65984277
74	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.65745290
75	Insulin signaling pathway_Homo sapiens_hsa04910	0.65083685
76	Pancreatic secretion_Homo sapiens_hsa04972	0.64698693
77	Serotonergic synapse_Homo sapiens_hsa04726	0.64020283
78	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.63174373
79	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.62931508
80	Butanoate metabolism_Homo sapiens_hsa00650	0.62682631
81	Wnt signaling pathway_Homo sapiens_hsa04310	0.62050680
82	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.60123481
83	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.58863086
84	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.58454529
85	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.55923737
86	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.55510262
87	Choline metabolism in cancer_Homo sapiens_hsa05231	0.54905286
88	Peroxisome_Homo sapiens_hsa04146	0.53813312
89	Histidine metabolism_Homo sapiens_hsa00340	0.53771006
90	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.53045772
91	mTOR signaling pathway_Homo sapiens_hsa04150	0.52985196
92	Rap1 signaling pathway_Homo sapiens_hsa04015	0.52970113
93	Adherens junction_Homo sapiens_hsa04520	0.52711366
94	Pyruvate metabolism_Homo sapiens_hsa00620	0.52646530
95	Fatty acid degradation_Homo sapiens_hsa00071	0.51593222
96	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.51308024
97	Glioma_Homo sapiens_hsa05214	0.51194408
98	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.51182978
99	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.49461165
100	Phototransduction_Homo sapiens_hsa04744	0.48677689

OR13E1P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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