ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.55288387
2	L-fucose catabolic process (GO:0042355)	4.86488940
3	fucose catabolic process (GO:0019317)	4.86488940
4	L-fucose metabolic process (GO:0042354)	4.86488940
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.27026005
6	DNA deamination (GO:0045006)	4.02391231
7	negative regulation of telomere maintenance (GO:0032205)	3.72066581
8	exogenous drug catabolic process (GO:0042738)	3.63618716
9	cellular ketone body metabolic process (GO:0046950)	3.61008354
10	indole-containing compound catabolic process (GO:0042436)	3.52570950
11	indolalkylamine catabolic process (GO:0046218)	3.52570950
12	tryptophan catabolic process (GO:0006569)	3.52570950
13	epithelial cilium movement (GO:0003351)	3.52088619
14	respiratory chain complex IV assembly (GO:0008535)	3.46447471
15	kidney morphogenesis (GO:0060993)	3.45597323
16	indolalkylamine metabolic process (GO:0006586)	3.41686085
17	water-soluble vitamin biosynthetic process (GO:0042364)	3.34758426
18	response to pheromone (GO:0019236)	3.33954542
19	sulfation (GO:0051923)	3.32520106
20	regulation of neurotransmitter uptake (GO:0051580)	3.30180771
21	tryptophan metabolic process (GO:0006568)	3.29672317
22	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.27900488
23	negative regulation of mast cell activation (GO:0033004)	3.25929213
24	nephron epithelium morphogenesis (GO:0072088)	3.23709474
25	nephron tubule morphogenesis (GO:0072078)	3.23709474
26	kynurenine metabolic process (GO:0070189)	3.22844468
27	ketone body metabolic process (GO:1902224)	3.18799480
28	arginine metabolic process (GO:0006525)	3.16476238
29	arginine catabolic process (GO:0006527)	3.15560934
30	axoneme assembly (GO:0035082)	3.15053249
31	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.14735429
32	drug catabolic process (GO:0042737)	3.10398642
33	piRNA metabolic process (GO:0034587)	3.10172473
34	protein polyglutamylation (GO:0018095)	3.10004358
35	adaptation of signaling pathway (GO:0023058)	3.07502408
36	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.05472666
37	pyrimidine nucleobase catabolic process (GO:0006208)	3.05361795
38	regulation of action potential (GO:0098900)	3.04465420
39	regulation of cilium movement (GO:0003352)	3.00258570
40	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.95733350
41	NADH dehydrogenase complex assembly (GO:0010257)	2.95733350
42	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.95733350
43	cellular biogenic amine catabolic process (GO:0042402)	2.95618646
44	amine catabolic process (GO:0009310)	2.95618646
45	protein complex biogenesis (GO:0070271)	2.94586633
46	cytochrome complex assembly (GO:0017004)	2.92660490
47	cornea development in camera-type eye (GO:0061303)	2.92519228
48	somite development (GO:0061053)	2.91075414
49	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.90135784
50	indole-containing compound metabolic process (GO:0042430)	2.85967841
51	auditory behavior (GO:0031223)	2.85401760
52	ubiquinone biosynthetic process (GO:0006744)	2.83787398
53	platelet dense granule organization (GO:0060155)	2.83111975
54	protein localization to cilium (GO:0061512)	2.82815277
55	nonmotile primary cilium assembly (GO:0035058)	2.81094141
56	detection of light stimulus involved in visual perception (GO:0050908)	2.80945753
57	detection of light stimulus involved in sensory perception (GO:0050962)	2.80945753
58	opioid receptor signaling pathway (GO:0038003)	2.80622308
59	fucosylation (GO:0036065)	2.80427472
60	cilium movement (GO:0003341)	2.79182771
61	regulation of hexokinase activity (GO:1903299)	2.78730608
62	regulation of glucokinase activity (GO:0033131)	2.78730608
63	reflex (GO:0060004)	2.78381547
64	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.77365361
65	primary amino compound metabolic process (GO:1901160)	2.75831267
66	neuronal action potential (GO:0019228)	2.75226579
67	ubiquinone metabolic process (GO:0006743)	2.73299736
68	mitochondrial respiratory chain complex assembly (GO:0033108)	2.71075717
69	preassembly of GPI anchor in ER membrane (GO:0016254)	2.65542745
70	protein-cofactor linkage (GO:0018065)	2.65306468
71	nucleobase catabolic process (GO:0046113)	2.65280869
72	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.60792951
73	positive regulation of guanylate cyclase activity (GO:0031284)	2.60559280
74	retinal cone cell development (GO:0046549)	2.58217259
75	regulation of microtubule-based movement (GO:0060632)	2.55630446
76	cytidine metabolic process (GO:0046087)	2.55283518
77	cytidine catabolic process (GO:0006216)	2.55283518
78	cytidine deamination (GO:0009972)	2.55283518
79	regulation of mitotic spindle checkpoint (GO:1903504)	2.55241986
80	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.55241986
81	gamma-aminobutyric acid transport (GO:0015812)	2.53205522
82	serotonin metabolic process (GO:0042428)	2.52756720
83	cilium morphogenesis (GO:0060271)	2.52635172
84	dopamine transport (GO:0015872)	2.52577884
85	regulation of hippo signaling (GO:0035330)	2.50931128
86	synaptic transmission, cholinergic (GO:0007271)	2.47641586
87	nitric oxide mediated signal transduction (GO:0007263)	2.45576355
88	positive regulation of fatty acid transport (GO:2000193)	2.45130356
89	smoothened signaling pathway (GO:0007224)	2.45022222
90	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.44474277
91	dendritic spine morphogenesis (GO:0060997)	2.44313438
92	negative regulation of neurotransmitter transport (GO:0051589)	2.44078742
93	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.42950386
94	renal tubule morphogenesis (GO:0061333)	2.42418222
95	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.41793905
96	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.39887475
97	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.36574338
98	determination of left/right symmetry (GO:0007368)	2.36465765
99	regulation of telomere maintenance (GO:0032204)	2.34791912
100	cilium organization (GO:0044782)	2.34760840

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.79469283
2	ZNF274_21170338_ChIP-Seq_K562_Hela	4.31243621
3	VDR_22108803_ChIP-Seq_LS180_Human	3.47351613
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.88961993
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.54718830
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.53521689
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.40685082
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.28389613
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.19141013
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.12912483
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.00694893
12	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.93908372
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.92512200
14	FUS_26573619_Chip-Seq_HEK293_Human	1.92328340
15	EWS_26573619_Chip-Seq_HEK293_Human	1.89233620
16	P300_19829295_ChIP-Seq_ESCs_Human	1.87503906
17	TAF15_26573619_Chip-Seq_HEK293_Human	1.81312621
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.77077093
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.70387106
20	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.68650686
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.67475044
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.65430079
23	REST_21632747_ChIP-Seq_MESCs_Mouse	1.64743841
24	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.60915435
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.58026618
26	BCAT_22108803_ChIP-Seq_LS180_Human	1.55820563
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.55320462
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.54493938
29	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.52522011
30	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.49407989
31	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.48566029
32	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.45307888
33	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.45070391
34	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44808485
35	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.44808485
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.44635239
37	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.42430008
38	AR_25329375_ChIP-Seq_VCAP_Human	1.42208270
39	RNF2_27304074_Chip-Seq_NSC_Mouse	1.40781490
40	STAT3_23295773_ChIP-Seq_U87_Human	1.39989858
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.39665107
42	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.39241790
43	SOX2_19829295_ChIP-Seq_ESCs_Human	1.38543501
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.38543501
45	SMAD4_21799915_ChIP-Seq_A2780_Human	1.38479981
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.37963258
47	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.37712412
48	AR_21572438_ChIP-Seq_LNCaP_Human	1.36149604
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.35946187
50	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.35946187
51	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.35875823
52	IRF1_19129219_ChIP-ChIP_H3396_Human	1.35842767
53	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.33535586
54	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.33162045
55	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.32938149
56	TCF4_23295773_ChIP-Seq_U87_Human	1.32196127
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.31455640
58	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.28586272
59	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.27673807
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.26315032
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.26315032
62	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.26072617
63	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.25478840
64	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.24453570
65	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.24310270
66	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24208699
67	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.22993475
68	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22873006
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21827262
70	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.21434339
71	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.20257547
72	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.20203045
73	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.19896067
74	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.14729026
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14526673
76	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.14052325
77	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.13260289
78	NCOR_22424771_ChIP-Seq_293T_Human	1.11936118
79	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.11655329
80	HOXB7_26014856_ChIP-Seq_BT474_Human	1.11512629
81	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.09962832
82	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09762782
83	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09426262
84	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.09384259
85	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.08176374
86	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08023748
87	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.05242693
88	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.05056481
89	AR_20517297_ChIP-Seq_VCAP_Human	1.04937353
90	DROSHA_22980978_ChIP-Seq_HELA_Human	1.04298997
91	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01470860
92	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.01013028
93	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.00253488
94	P53_22387025_ChIP-Seq_ESCs_Mouse	0.99047657
95	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98459886
96	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.97358090
97	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97296219
98	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.96839479
99	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.96370205
100	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.96277167

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	2.77034838
2	MP0003195_calcinosis	2.65709166
3	MP0004043_abnormal_pH_regulation	2.48513783
4	MP0002102_abnormal_ear_morphology	2.46909297
5	MP0003283_abnormal_digestive_organ	2.36751623
6	MP0008877_abnormal_DNA_methylation	2.36240301
7	MP0002653_abnormal_ependyma_morphology	2.30080456
8	MP0003011_delayed_dark_adaptation	2.22636550
9	MP0005645_abnormal_hypothalamus_physiol	2.20171331
10	MP0005167_abnormal_blood-brain_barrier	2.18031837
11	MP0004133_heterotaxia	2.17864847
12	MP0005551_abnormal_eye_electrophysiolog	2.16631988
13	MP0004147_increased_porphyrin_level	2.11662451
14	MP0000566_synostosis	2.10270843
15	MP0009745_abnormal_behavioral_response	2.07838312
16	MP0008872_abnormal_physiological_respon	2.06085561
17	MP0003880_abnormal_central_pattern	2.05901328
18	MP0004885_abnormal_endolymph	1.96623576
19	MP0000569_abnormal_digit_pigmentation	1.95482999
20	MP0002234_abnormal_pharynx_morphology	1.94369955
21	MP0002638_abnormal_pupillary_reflex	1.93058729
22	MP0001968_abnormal_touch/_nociception	1.89364973
23	MP0009046_muscle_twitch	1.87303253
24	MP0003136_yellow_coat_color	1.84605902
25	MP0004142_abnormal_muscle_tone	1.77519688
26	MP0002876_abnormal_thyroid_physiology	1.73851216
27	MP0008875_abnormal_xenobiotic_pharmacok	1.72892052
28	MP0001501_abnormal_sleep_pattern	1.72816836
29	MP0002272_abnormal_nervous_system	1.71758285
30	MP0005084_abnormal_gallbladder_morpholo	1.62711817
31	MP0002837_dystrophic_cardiac_calcinosis	1.58930916
32	MP0000372_irregular_coat_pigmentation	1.57200372
33	MP0001986_abnormal_taste_sensitivity	1.56315533
34	MP0003787_abnormal_imprinting	1.53678103
35	MP0006072_abnormal_retinal_apoptosis	1.52281497
36	MP0002938_white_spotting	1.49686486
37	MP0006276_abnormal_autonomic_nervous	1.46894018
38	MP0005423_abnormal_somatic_nervous	1.46521782
39	MP0002735_abnormal_chemical_nociception	1.45411142
40	MP0002163_abnormal_gland_morphology	1.44543245
41	MP0001485_abnormal_pinna_reflex	1.44311062
42	MP0002064_seizures	1.44065453
43	MP0002736_abnormal_nociception_after	1.43751095
44	MP0002572_abnormal_emotion/affect_behav	1.41663357
45	MP0003718_maternal_effect	1.40384464
46	MP0002928_abnormal_bile_duct	1.38584747
47	MP0000383_abnormal_hair_follicle	1.37652692
48	MP0005379_endocrine/exocrine_gland_phen	1.35625863
49	MP0001970_abnormal_pain_threshold	1.35348973
50	MP0005253_abnormal_eye_physiology	1.34882388
51	MP0000631_abnormal_neuroendocrine_gland	1.34406690
52	MP0002557_abnormal_social/conspecific_i	1.33583930
53	MP0004742_abnormal_vestibular_system	1.31900115
54	MP0001486_abnormal_startle_reflex	1.30121950
55	MP0001529_abnormal_vocalization	1.29919349
56	MP0002277_abnormal_respiratory_mucosa	1.26800439
57	MP0005646_abnormal_pituitary_gland	1.25901621
58	MP0006292_abnormal_olfactory_placode	1.22327883
59	MP0005389_reproductive_system_phenotype	1.20127104
60	MP0000427_abnormal_hair_cycle	1.17337795
61	MP0009379_abnormal_foot_pigmentation	1.16992527
62	MP0002733_abnormal_thermal_nociception	1.16574797
63	MP0001919_abnormal_reproductive_system	1.15860654
64	MP0008775_abnormal_heart_ventricle	1.15747040
65	MP0001905_abnormal_dopamine_level	1.15167533
66	MP0002063_abnormal_learning/memory/cond	1.12739222
67	MP0002067_abnormal_sensory_capabilities	1.12510944
68	MP0003122_maternal_imprinting	1.11755706
69	MP0005174_abnormal_tail_pigmentation	1.10620920
70	MP0002734_abnormal_mechanical_nocicepti	1.08625171
71	MP0003635_abnormal_synaptic_transmissio	1.08276628
72	MP0001440_abnormal_grooming_behavior	1.08230028
73	MP0001984_abnormal_olfaction	1.05956989
74	MP0002751_abnormal_autonomic_nervous	1.04611671
75	MP0003119_abnormal_digestive_system	1.04399244
76	MP0005377_hearing/vestibular/ear_phenot	1.01420273
77	MP0003878_abnormal_ear_physiology	1.01420273
78	MP0002184_abnormal_innervation	0.99823870
79	MP0008995_early_reproductive_senescence	0.99377400
80	MP0000778_abnormal_nervous_system	0.97381842
81	MP0005195_abnormal_posterior_eye	0.96844550
82	MP0004924_abnormal_behavior	0.95257567
83	MP0005386_behavior/neurological_phenoty	0.95257567
84	MP0000026_abnormal_inner_ear	0.94950367
85	MP0003937_abnormal_limbs/digits/tail_de	0.92971266
86	MP0002160_abnormal_reproductive_system	0.92094928
87	MP0000230_abnormal_systemic_arterial	0.88966797
88	MP0002752_abnormal_somatic_nervous	0.87833155
89	MP0010386_abnormal_urinary_bladder	0.82319812
90	MP0004145_abnormal_muscle_electrophysio	0.81617416
91	MP0003121_genomic_imprinting	0.80184132
92	MP0000955_abnormal_spinal_cord	0.78938661
93	MP0002693_abnormal_pancreas_physiology	0.76803909
94	MP0003938_abnormal_ear_development	0.76654736
95	MP0002909_abnormal_adrenal_gland	0.75817049
96	MP0001963_abnormal_hearing_physiology	0.74480913
97	MP0005332_abnormal_amino_acid	0.74254329
98	MP0001664_abnormal_digestion	0.74077598
99	MP0002229_neurodegeneration	0.71333722
100	MP0001944_abnormal_pancreas_morphology	0.70334989

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.84963299
2	Pancreatic fibrosis (HP:0100732)	4.33147436
3	Congenital stationary night blindness (HP:0007642)	4.31586938
4	Molar tooth sign on MRI (HP:0002419)	4.13273285
5	Abnormality of midbrain morphology (HP:0002418)	4.13273285
6	Type II lissencephaly (HP:0007260)	4.06757169
7	True hermaphroditism (HP:0010459)	4.04137328
8	Nephronophthisis (HP:0000090)	3.47374454
9	Abnormality of the renal cortex (HP:0011035)	3.43769070
10	Hyperventilation (HP:0002883)	3.38506247
11	Abnormal rod and cone electroretinograms (HP:0008323)	3.08898349
12	Cerebellar dysplasia (HP:0007033)	3.08386608
13	Concave nail (HP:0001598)	3.02423572
14	Abnormality of the renal medulla (HP:0100957)	2.99302153
15	Medial flaring of the eyebrow (HP:0010747)	2.90032007
16	Congenital, generalized hypertrichosis (HP:0004540)	2.88749063
17	Lissencephaly (HP:0001339)	2.88199348
18	Cystic liver disease (HP:0006706)	2.86304816
19	Renal cortical cysts (HP:0000803)	2.86103877
20	Pendular nystagmus (HP:0012043)	2.74525822
21	Tubular atrophy (HP:0000092)	2.61143028
22	Abnormal drinking behavior (HP:0030082)	2.59108819
23	Polydipsia (HP:0001959)	2.59108819
24	Gait imbalance (HP:0002141)	2.54679541
25	Keratoconus (HP:0000563)	2.53089551
26	Increased corneal curvature (HP:0100692)	2.53089551
27	Chronic hepatic failure (HP:0100626)	2.49416677
28	Attenuation of retinal blood vessels (HP:0007843)	2.49316577
29	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.47596150
30	Hypoplasia of the fovea (HP:0007750)	2.47596150
31	Sclerocornea (HP:0000647)	2.43876139
32	Stomach cancer (HP:0012126)	2.41072816
33	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.36979628
34	Congenital primary aphakia (HP:0007707)	2.36321572
35	Abnormality of alanine metabolism (HP:0010916)	2.35120626
36	Hyperalaninemia (HP:0003348)	2.35120626
37	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.35120626
38	Abolished electroretinogram (ERG) (HP:0000550)	2.35071973
39	Inability to walk (HP:0002540)	2.30344206
40	Bile duct proliferation (HP:0001408)	2.27948217
41	Abnormal biliary tract physiology (HP:0012439)	2.27948217
42	Abnormality of the fovea (HP:0000493)	2.26168690
43	Decreased central vision (HP:0007663)	2.23642226
44	Bilateral microphthalmos (HP:0007633)	2.20137336
45	Hypothermia (HP:0002045)	2.20033669
46	Anencephaly (HP:0002323)	2.19914488
47	Birth length less than 3rd percentile (HP:0003561)	2.18450284
48	Limb dystonia (HP:0002451)	2.17726892
49	Broad-based gait (HP:0002136)	2.17213230
50	Congenital hepatic fibrosis (HP:0002612)	2.16155892
51	Polyuria (HP:0000103)	2.15983188
52	Patellar aplasia (HP:0006443)	2.15747418
53	Pachygyria (HP:0001302)	2.15383238
54	Nephrogenic diabetes insipidus (HP:0009806)	2.14534483
55	Acute necrotizing encephalopathy (HP:0006965)	2.14461422
56	Mitochondrial inheritance (HP:0001427)	2.10986797
57	Furrowed tongue (HP:0000221)	2.09825169
58	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.07988453
59	Aplasia/Hypoplasia of the patella (HP:0006498)	2.07376308
60	Agitation (HP:0000713)	2.06385913
61	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.06041725
62	Abnormal respiratory motile cilium morphology (HP:0005938)	2.05790755
63	Abnormal respiratory epithelium morphology (HP:0012253)	2.05790755
64	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.05398396
65	Hemiparesis (HP:0001269)	2.05386137
66	Male pseudohermaphroditism (HP:0000037)	2.05383739
67	Aplasia/hypoplasia of the uterus (HP:0008684)	2.01808782
68	Optic disc pallor (HP:0000543)	2.01669340
69	Postaxial foot polydactyly (HP:0001830)	2.00766237
70	Absent/shortened dynein arms (HP:0200106)	2.00718257
71	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.00718257
72	Abnormality of the pons (HP:0007361)	1.98764740
73	Depressed nasal tip (HP:0000437)	1.97531038
74	Conical tooth (HP:0000698)	1.96095439
75	Increased CSF lactate (HP:0002490)	1.94613026
76	Severe muscular hypotonia (HP:0006829)	1.92361143
77	Autoimmune thrombocytopenia (HP:0001973)	1.91576834
78	Large for gestational age (HP:0001520)	1.90672373
79	Optic nerve hypoplasia (HP:0000609)	1.89532139
80	Genital tract atresia (HP:0001827)	1.89501347
81	Febrile seizures (HP:0002373)	1.88883866
82	Progressive macrocephaly (HP:0004481)	1.87444878
83	Progressive cerebellar ataxia (HP:0002073)	1.87370540
84	Hypoplasia of the pons (HP:0012110)	1.86525910
85	Vaginal atresia (HP:0000148)	1.86012857
86	Abnormality of macular pigmentation (HP:0008002)	1.84500858
87	Acute encephalopathy (HP:0006846)	1.84264345
88	3-Methylglutaconic aciduria (HP:0003535)	1.84207692
89	Decreased circulating renin level (HP:0003351)	1.82946916
90	Fair hair (HP:0002286)	1.81375004
91	Gaze-evoked nystagmus (HP:0000640)	1.80469073
92	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.79574216
93	Abnormality of the labia minora (HP:0012880)	1.78668448
94	Progressive inability to walk (HP:0002505)	1.78011604
95	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.77197420
96	Supernumerary spleens (HP:0009799)	1.76442765
97	Tachypnea (HP:0002789)	1.75372664
98	Lipid accumulation in hepatocytes (HP:0006561)	1.74869757
99	Hypomagnesemia (HP:0002917)	1.74603937
100	Dandy-Walker malformation (HP:0001305)	1.74510881

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	3.72658147
2	FRK	3.58119179
3	ADRBK2	3.39035392
4	ZAK	3.22814869
5	BMPR1B	2.87051339
6	PINK1	2.77367643
7	GRK1	2.60793535
8	STK39	2.55603137
9	CASK	2.51002449
10	STK24	2.24347566
11	TXK	2.16209093
12	WNK3	2.14916594
13	MAP4K2	2.14531780
14	TLK1	2.13547624
15	ACVR1B	2.06205749
16	DAPK2	2.00432079
17	INSRR	1.94370952
18	TAOK3	1.91123807
19	MAPK15	1.90155027
20	PNCK	1.86941267
21	MAPK13	1.81216887
22	MARK1	1.37088107
23	NUAK1	1.37028783
24	MKNK2	1.36915108
25	OXSR1	1.27795794
26	TIE1	1.16937228
27	MAP3K4	1.15658765
28	NTRK2	1.14710935
29	TGFBR1	1.13664234
30	ADRBK1	1.11924516
31	DYRK2	1.11195856
32	PAK3	1.08225817
33	PRKCG	1.04545111
34	STK38L	1.02586780
35	CAMKK2	0.99744126
36	TNIK	0.97675330
37	NTRK3	0.95614051
38	VRK1	0.95518341
39	WEE1	0.93710056
40	PRKCQ	0.91102548
41	CAMK1	0.88837972
42	MAPKAPK3	0.87446102
43	WNK1	0.85563221
44	MUSK	0.83961264
45	MAPKAPK5	0.82732104
46	PHKG2	0.80494310
47	PHKG1	0.80494310
48	CSNK1G2	0.77861823
49	TRIM28	0.76166297
50	BRSK2	0.74624785
51	PRKCE	0.70924352
52	MAP2K7	0.68867701
53	BCKDK	0.68805882
54	MKNK1	0.68473320
55	CSNK1G1	0.67280584
56	PIK3CA	0.65185831
57	CSNK1G3	0.63352750
58	PTK2B	0.63352205
59	CAMK4	0.62297949
60	VRK2	0.62200246
61	PLK3	0.58821558
62	CHEK2	0.57821176
63	IKBKB	0.57496965
64	TEC	0.56990639
65	SIK2	0.54252248
66	MST4	0.54075906
67	MAP3K2	0.53584228
68	TAF1	0.52468292
69	PASK	0.51290009
70	PLK2	0.50908237
71	CAMK2A	0.50774167
72	NEK2	0.47961418
73	STK16	0.47408144
74	CCNB1	0.46949451
75	JAK3	0.46534791
76	FGFR2	0.44541379
77	PRKACA	0.43707364
78	KIT	0.43597750
79	CAMKK1	0.42854624
80	PKN1	0.42278542
81	CHUK	0.41202656
82	GRK7	0.41169763
83	MAP3K12	0.40891752
84	PRKCZ	0.40390143
85	RPS6KA5	0.39624665
86	NME1	0.39188005
87	IRAK1	0.38211552
88	BCR	0.38191417
89	TSSK6	0.36956591
90	LIMK1	0.35792724
91	PRKCI	0.35746299
92	RPS6KA6	0.35502379
93	MAP2K6	0.34426917
94	EIF2AK2	0.33119516
95	PRKAA2	0.32532877
96	MAP2K1	0.31715104
97	PRKCA	0.31414801
98	SYK	0.30887186
99	MAP2K4	0.30062612
100	DYRK1A	0.29979508

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.83534846
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.70954416
3	Nitrogen metabolism_Homo sapiens_hsa00910	2.62760601
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.62445300
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.57610455
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.53402504
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.52289086
8	Butanoate metabolism_Homo sapiens_hsa00650	2.48817757
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.44366745
10	Nicotine addiction_Homo sapiens_hsa05033	2.42621615
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.14395448
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.11282117
13	Selenocompound metabolism_Homo sapiens_hsa00450	2.10327814
14	Protein export_Homo sapiens_hsa03060	2.05180839
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.05104761
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.01737973
17	Parkinsons disease_Homo sapiens_hsa05012	1.97844254
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.80259439
19	Caffeine metabolism_Homo sapiens_hsa00232	1.72886203
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.72210705
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.68324274
22	Cardiac muscle contraction_Homo sapiens_hsa04260	1.51843933
23	Morphine addiction_Homo sapiens_hsa05032	1.42283024
24	Taste transduction_Homo sapiens_hsa04742	1.40831136
25	Alzheimers disease_Homo sapiens_hsa05010	1.39919009
26	Basal transcription factors_Homo sapiens_hsa03022	1.32721629
27	Huntingtons disease_Homo sapiens_hsa05016	1.26315765
28	GABAergic synapse_Homo sapiens_hsa04727	1.24489167
29	Circadian entrainment_Homo sapiens_hsa04713	1.23778990
30	Peroxisome_Homo sapiens_hsa04146	1.16166629
31	Olfactory transduction_Homo sapiens_hsa04740	1.12719645
32	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.11967981
33	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.09249773
34	Serotonergic synapse_Homo sapiens_hsa04726	1.09140114
35	RNA degradation_Homo sapiens_hsa03018	1.06907542
36	ABC transporters_Homo sapiens_hsa02010	1.05253644
37	Insulin secretion_Homo sapiens_hsa04911	1.04789948
38	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.04780713
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.04572526
40	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.04380234
41	RNA polymerase_Homo sapiens_hsa03020	1.03730497
42	Glutamatergic synapse_Homo sapiens_hsa04724	1.03624372
43	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.02185175
44	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01841162
45	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.01776322
46	One carbon pool by folate_Homo sapiens_hsa00670	0.98925685
47	Homologous recombination_Homo sapiens_hsa03440	0.97415149
48	Retinol metabolism_Homo sapiens_hsa00830	0.97297748
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.96311596
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.95779535
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.95687856
52	Regulation of autophagy_Homo sapiens_hsa04140	0.95469022
53	Fanconi anemia pathway_Homo sapiens_hsa03460	0.95417567
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93467923
55	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.89815174
56	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.89619510
57	Propanoate metabolism_Homo sapiens_hsa00640	0.87891370
58	beta-Alanine metabolism_Homo sapiens_hsa00410	0.82075194
59	Steroid biosynthesis_Homo sapiens_hsa00100	0.81633875
60	Salivary secretion_Homo sapiens_hsa04970	0.80675406
61	Fat digestion and absorption_Homo sapiens_hsa04975	0.80266453
62	Asthma_Homo sapiens_hsa05310	0.79955882
63	Dopaminergic synapse_Homo sapiens_hsa04728	0.76916988
64	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.76726489
65	Calcium signaling pathway_Homo sapiens_hsa04020	0.74949754
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.72876800
67	Primary immunodeficiency_Homo sapiens_hsa05340	0.71129121
68	Fatty acid elongation_Homo sapiens_hsa00062	0.68969535
69	Glycerolipid metabolism_Homo sapiens_hsa00561	0.67873050
70	Ribosome_Homo sapiens_hsa03010	0.65048833
71	Amphetamine addiction_Homo sapiens_hsa05031	0.63746508
72	Histidine metabolism_Homo sapiens_hsa00340	0.63203225
73	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.61105971
74	Sulfur metabolism_Homo sapiens_hsa00920	0.60784232
75	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.55915686
76	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.55875528
77	Mineral absorption_Homo sapiens_hsa04978	0.54816958
78	Metabolic pathways_Homo sapiens_hsa01100	0.53497985
79	Long-term depression_Homo sapiens_hsa04730	0.53266156
80	Type I diabetes mellitus_Homo sapiens_hsa04940	0.53136422
81	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.52028030
82	Cocaine addiction_Homo sapiens_hsa05030	0.51163048
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.49176398
84	Proteasome_Homo sapiens_hsa03050	0.47597141
85	Rheumatoid arthritis_Homo sapiens_hsa05323	0.45690749
86	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.44441310
87	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.43753594
88	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.42717363
89	Cholinergic synapse_Homo sapiens_hsa04725	0.40762170
90	Gastric acid secretion_Homo sapiens_hsa04971	0.40501480
91	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.38381127
92	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.38316910
93	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.37418756
94	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.37189255
95	Arginine biosynthesis_Homo sapiens_hsa00220	0.35524823
96	cAMP signaling pathway_Homo sapiens_hsa04024	0.34223209
97	Purine metabolism_Homo sapiens_hsa00230	0.34111275
98	Arginine and proline metabolism_Homo sapiens_hsa00330	0.33034642
99	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.32367378
100	Basal cell carcinoma_Homo sapiens_hsa05217	0.31625050

OR13I1P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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