ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.23676417
2	response to pheromone (GO:0019236)	4.88026037
3	platelet dense granule organization (GO:0060155)	4.22570376
4	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.07269953
5	L-fucose catabolic process (GO:0042355)	4.03842674
6	fucose catabolic process (GO:0019317)	4.03842674
7	L-fucose metabolic process (GO:0042354)	4.03842674
8	negative regulation of telomere maintenance (GO:0032205)	3.97445670
9	DNA deamination (GO:0045006)	3.93387299
10	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.62302751
11	indolalkylamine metabolic process (GO:0006586)	3.54460569
12	protein polyglutamylation (GO:0018095)	3.52901055
13	nonmotile primary cilium assembly (GO:0035058)	3.31735407
14	axoneme assembly (GO:0035082)	3.28372261
15	endoderm formation (GO:0001706)	3.25925622
16	water-soluble vitamin biosynthetic process (GO:0042364)	3.25226262
17	protein neddylation (GO:0045116)	3.24775101
18	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.24404351
19	NADH dehydrogenase complex assembly (GO:0010257)	3.24404351
20	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.24404351
21	indole-containing compound catabolic process (GO:0042436)	3.20904485
22	indolalkylamine catabolic process (GO:0046218)	3.20904485
23	tryptophan catabolic process (GO:0006569)	3.20904485
24	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.16889797
25	ubiquinone biosynthetic process (GO:0006744)	3.16222822
26	protein complex biogenesis (GO:0070271)	3.15991580
27	epithelial cilium movement (GO:0003351)	3.14799082
28	kynurenine metabolic process (GO:0070189)	3.13920611
29	cellular ketone body metabolic process (GO:0046950)	3.09871843
30	detection of light stimulus involved in visual perception (GO:0050908)	3.08307235
31	detection of light stimulus involved in sensory perception (GO:0050962)	3.08307235
32	cell proliferation in forebrain (GO:0021846)	3.04057820
33	positive regulation of fatty acid transport (GO:2000193)	3.02327237
34	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.97568182
35	piRNA metabolic process (GO:0034587)	2.97362418
36	behavioral response to ethanol (GO:0048149)	2.93824567
37	transmission of nerve impulse (GO:0019226)	2.93172111
38	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.91437346
39	somite development (GO:0061053)	2.91182623
40	rhodopsin mediated signaling pathway (GO:0016056)	2.90958343
41	mitochondrial respiratory chain complex assembly (GO:0033108)	2.87069507
42	ubiquinone metabolic process (GO:0006743)	2.86763475
43	pyrimidine nucleobase catabolic process (GO:0006208)	2.86315519
44	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.85463034
45	ketone body metabolic process (GO:1902224)	2.85382525
46	nephron tubule morphogenesis (GO:0072078)	2.83985488
47	nephron epithelium morphogenesis (GO:0072088)	2.83985488
48	postsynaptic membrane organization (GO:0001941)	2.78989624
49	adaptation of signaling pathway (GO:0023058)	2.78515402
50	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.75903538
51	tryptophan metabolic process (GO:0006568)	2.73601788
52	synaptic transmission, cholinergic (GO:0007271)	2.73187899
53	protein-cofactor linkage (GO:0018065)	2.72716016
54	positive regulation of defense response to virus by host (GO:0002230)	2.71474176
55	cilium morphogenesis (GO:0060271)	2.69734218
56	positive regulation of prostaglandin secretion (GO:0032308)	2.69409553
57	cornea development in camera-type eye (GO:0061303)	2.68460370
58	regulation of telomere maintenance (GO:0032204)	2.66693111
59	neuronal action potential (GO:0019228)	2.66378928
60	indole-containing compound metabolic process (GO:0042430)	2.64394960
61	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.63993497
62	positive regulation of icosanoid secretion (GO:0032305)	2.62804467
63	cilium movement (GO:0003341)	2.62653826
64	cAMP catabolic process (GO:0006198)	2.62228541
65	negative regulation of mast cell activation (GO:0033004)	2.60949069
66	kidney morphogenesis (GO:0060993)	2.60368696
67	mannosylation (GO:0097502)	2.59394493
68	cellular response to ATP (GO:0071318)	2.59120057
69	gamma-aminobutyric acid transport (GO:0015812)	2.58454619
70	nucleobase catabolic process (GO:0046113)	2.57890342
71	regulation of action potential (GO:0098900)	2.57630110
72	DNA methylation involved in gamete generation (GO:0043046)	2.57373156
73	preassembly of GPI anchor in ER membrane (GO:0016254)	2.56876795
74	regulation of cilium movement (GO:0003352)	2.51338507
75	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.50477209
76	quinone biosynthetic process (GO:1901663)	2.50314135
77	retinal ganglion cell axon guidance (GO:0031290)	2.49446483
78	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.49075365
79	reflex (GO:0060004)	2.47468674
80	cytidine metabolic process (GO:0046087)	2.47303865
81	cytidine catabolic process (GO:0006216)	2.47303865
82	cytidine deamination (GO:0009972)	2.47303865
83	auditory receptor cell stereocilium organization (GO:0060088)	2.46425805
84	respiratory chain complex IV assembly (GO:0008535)	2.45686364
85	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.45531641
86	regulation of memory T cell differentiation (GO:0043380)	2.44869224
87	primary amino compound metabolic process (GO:1901160)	2.44832030
88	parturition (GO:0007567)	2.43766916
89	amine catabolic process (GO:0009310)	2.43751563
90	cellular biogenic amine catabolic process (GO:0042402)	2.43751563
91	photoreceptor cell development (GO:0042461)	2.43318070
92	mitotic cell cycle arrest (GO:0071850)	2.43228771
93	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.42522407
94	neuron fate determination (GO:0048664)	2.38502484
95	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.38374272
96	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.38035997
97	rRNA catabolic process (GO:0016075)	2.37739926
98	multicellular organism reproduction (GO:0032504)	2.35529863
99	regulation of microtubule-based movement (GO:0060632)	2.35152703
100	cilium organization (GO:0044782)	2.34932066

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.81888423
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.73735695
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.98849985
4	VDR_22108803_ChIP-Seq_LS180_Human	2.88738330
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.83680144
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.61171037
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.57925960
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.33905614
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.03783875
10	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.01453131
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.01339635
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.01125853
13	IGF1R_20145208_ChIP-Seq_DFB_Human	1.98722547
14	TAF15_26573619_Chip-Seq_HEK293_Human	1.98376123
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.95754702
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.94062790
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.87323835
18	FUS_26573619_Chip-Seq_HEK293_Human	1.86445347
19	P300_19829295_ChIP-Seq_ESCs_Human	1.79456349
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.77939100
21	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.77739520
22	EWS_26573619_Chip-Seq_HEK293_Human	1.73176468
23	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.72686364
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.72381066
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.68483488
26	REST_21632747_ChIP-Seq_MESCs_Mouse	1.67273554
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.54503424
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.54258430
29	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.50658649
30	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.47099431
31	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.46998867
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.45883256
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.44335680
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.44335680
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.43479798
36	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.42899873
37	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.41288479
38	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.39958615
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.38763731
40	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.37605401
41	STAT3_23295773_ChIP-Seq_U87_Human	1.37402284
42	AR_25329375_ChIP-Seq_VCAP_Human	1.37392503
43	SOX2_19829295_ChIP-Seq_ESCs_Human	1.36357447
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.36357447
45	NCOR_22424771_ChIP-Seq_293T_Human	1.35535081
46	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.35095592
47	RNF2_27304074_Chip-Seq_NSC_Mouse	1.35009009
48	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.34560772
49	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.33922020
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.33922020
51	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.33888121
52	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.32949168
53	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.32242087
54	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.30926995
55	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.29775237
56	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.29775237
57	SMAD4_21799915_ChIP-Seq_A2780_Human	1.29465187
58	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.29425713
59	BCAT_22108803_ChIP-Seq_LS180_Human	1.29140970
60	TCF4_23295773_ChIP-Seq_U87_Human	1.28625722
61	AR_21572438_ChIP-Seq_LNCaP_Human	1.27208148
62	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.27125424
63	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.26902574
64	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.26862877
65	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.26373000
66	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.25063391
67	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.24993196
68	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.24100272
69	AR_20517297_ChIP-Seq_VCAP_Human	1.22795628
70	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.20905998
71	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.16911259
72	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.16722894
73	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.15239506
74	RUNX2_22187159_ChIP-Seq_PCA_Human	1.15061875
75	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.15052710
76	TCF4_22108803_ChIP-Seq_LS180_Human	1.14662815
77	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.13158158
78	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12368843
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.11248964
80	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.07861491
81	HOXB7_26014856_ChIP-Seq_BT474_Human	1.07374767
82	P53_21459846_ChIP-Seq_SAOS-2_Human	1.07260160
83	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06024649
84	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.03726385
85	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.03605728
86	MYC_19829295_ChIP-Seq_ESCs_Human	1.02979913
87	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.02357948
88	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.02347498
89	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.01532502
90	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01478285
91	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.01070256
92	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.01000665
93	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00586292
94	ERA_21632823_ChIP-Seq_H3396_Human	1.00486389
95	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99445747
96	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.98824626
97	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.97922939
98	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.97217244
99	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.96436896
100	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.96158887

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.79254338
2	MP0003787_abnormal_imprinting	2.65750148
3	MP0003195_calcinosis	2.47298062
4	MP0001986_abnormal_taste_sensitivity	2.43627582
5	MP0002837_dystrophic_cardiac_calcinosis	2.40124400
6	MP0004885_abnormal_endolymph	2.33725856
7	MP0002876_abnormal_thyroid_physiology	2.33445560
8	MP0006292_abnormal_olfactory_placode	2.31124256
9	MP0005551_abnormal_eye_electrophysiolog	2.30335007
10	MP0003646_muscle_fatigue	2.28473024
11	MP0001968_abnormal_touch/_nociception	2.25970315
12	MP0003136_yellow_coat_color	2.25342037
13	MP0002163_abnormal_gland_morphology	2.11309852
14	MP0006072_abnormal_retinal_apoptosis	2.08990026
15	MP0003880_abnormal_central_pattern	2.08468212
16	MP0004133_heterotaxia	2.06829273
17	MP0004147_increased_porphyrin_level	2.05639335
18	MP0000372_irregular_coat_pigmentation	1.96820166
19	MP0004142_abnormal_muscle_tone	1.95960456
20	MP0002102_abnormal_ear_morphology	1.93218756
21	MP0002736_abnormal_nociception_after	1.88088260
22	MP0002653_abnormal_ependyma_morphology	1.85217075
23	MP0005174_abnormal_tail_pigmentation	1.81059223
24	MP0006276_abnormal_autonomic_nervous	1.80543675
25	MP0002272_abnormal_nervous_system	1.78771365
26	MP0005075_abnormal_melanosome_morpholog	1.78294658
27	MP0001485_abnormal_pinna_reflex	1.74503123
28	MP0005253_abnormal_eye_physiology	1.73797538
29	MP0009745_abnormal_behavioral_response	1.71747889
30	MP0004742_abnormal_vestibular_system	1.71537372
31	MP0008875_abnormal_xenobiotic_pharmacok	1.69388241
32	MP0009379_abnormal_foot_pigmentation	1.67264255
33	MP0008872_abnormal_physiological_respon	1.64524930
34	MP0003283_abnormal_digestive_organ	1.57336339
35	MP0000569_abnormal_digit_pigmentation	1.56157437
36	MP0002928_abnormal_bile_duct	1.54310532
37	MP0005084_abnormal_gallbladder_morpholo	1.53203874
38	MP0005379_endocrine/exocrine_gland_phen	1.51735049
39	MP0003011_delayed_dark_adaptation	1.51461869
40	MP0002095_abnormal_skin_pigmentation	1.49403674
41	MP0002938_white_spotting	1.48797221
42	MP0009046_muscle_twitch	1.48651925
43	MP0001919_abnormal_reproductive_system	1.45691427
44	MP0000427_abnormal_hair_cycle	1.44553453
45	MP0001501_abnormal_sleep_pattern	1.43770167
46	MP0005389_reproductive_system_phenotype	1.40852860
47	MP0004043_abnormal_pH_regulation	1.40035553
48	MP0005646_abnormal_pituitary_gland	1.37024758
49	MP0002557_abnormal_social/conspecific_i	1.32649304
50	MP0000015_abnormal_ear_pigmentation	1.32642252
51	MP0000631_abnormal_neuroendocrine_gland	1.31576024
52	MP0001486_abnormal_startle_reflex	1.29636008
53	MP0002638_abnormal_pupillary_reflex	1.26979905
54	MP0002160_abnormal_reproductive_system	1.25493103
55	MP0002572_abnormal_emotion/affect_behav	1.23939687
56	MP0005195_abnormal_posterior_eye	1.18502108
57	MP0005645_abnormal_hypothalamus_physiol	1.16061650
58	MP0001529_abnormal_vocalization	1.12640460
59	MP0002733_abnormal_thermal_nociception	1.11455985
60	MP0008775_abnormal_heart_ventricle	1.10908411
61	MP0001970_abnormal_pain_threshold	1.08599517
62	MP0004145_abnormal_muscle_electrophysio	1.08339176
63	MP0001324_abnormal_eye_pigmentation	1.06205225
64	MP0001984_abnormal_olfaction	1.05220330
65	MP0001905_abnormal_dopamine_level	1.03963223
66	MP0003635_abnormal_synaptic_transmissio	1.03745109
67	MP0003878_abnormal_ear_physiology	1.03696452
68	MP0005377_hearing/vestibular/ear_phenot	1.03696452
69	MP0002067_abnormal_sensory_capabilities	1.03563406
70	MP0005386_behavior/neurological_phenoty	1.02001089
71	MP0004924_abnormal_behavior	1.02001089
72	MP0002234_abnormal_pharynx_morphology	1.01070705
73	MP0002064_seizures	1.00180082
74	MP0003121_genomic_imprinting	0.98455329
75	MP0002735_abnormal_chemical_nociception	0.97435317
76	MP0002752_abnormal_somatic_nervous	0.96742624
77	MP0000230_abnormal_systemic_arterial	0.95791845
78	MP0000026_abnormal_inner_ear	0.94940474
79	MP0003122_maternal_imprinting	0.94081887
80	MP0000778_abnormal_nervous_system	0.93983055
81	MP0005423_abnormal_somatic_nervous	0.93978028
82	MP0010386_abnormal_urinary_bladder	0.92894280
83	MP0002063_abnormal_learning/memory/cond	0.92788911
84	MP0002734_abnormal_mechanical_nocicepti	0.92701300
85	MP0003119_abnormal_digestive_system	0.90843863
86	MP0002822_catalepsy	0.89054505
87	MP0001963_abnormal_hearing_physiology	0.85458154
88	MP0003890_abnormal_embryonic-extraembry	0.84806221
89	MP0001502_abnormal_circadian_rhythm	0.83446166
90	MP0002229_neurodegeneration	0.82405338
91	MP0003137_abnormal_impulse_conducting	0.81339070
92	MP0004130_abnormal_muscle_cell	0.80614245
93	MP0000538_abnormal_urinary_bladder	0.79562784
94	MP0002184_abnormal_innervation	0.77251085
95	MP0003252_abnormal_bile_duct	0.77163885
96	MP0001293_anophthalmia	0.76728106
97	MP0002909_abnormal_adrenal_gland	0.75879812
98	MP0000383_abnormal_hair_follicle	0.75035616
99	MP0001440_abnormal_grooming_behavior	0.74666378
100	MP0002277_abnormal_respiratory_mucosa	0.73688855

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.35698753
2	Type II lissencephaly (HP:0007260)	4.31789537
3	Molar tooth sign on MRI (HP:0002419)	4.26261088
4	Abnormality of midbrain morphology (HP:0002418)	4.26261088
5	Pancreatic fibrosis (HP:0100732)	4.17754355
6	True hermaphroditism (HP:0010459)	3.84277872
7	Congenital stationary night blindness (HP:0007642)	3.82161631
8	Nephronophthisis (HP:0000090)	3.70808003
9	Abnormality of the renal medulla (HP:0100957)	3.33112145
10	Abnormality of the renal cortex (HP:0011035)	3.31552768
11	Tubular atrophy (HP:0000092)	2.99639572
12	Medial flaring of the eyebrow (HP:0010747)	2.93346901
13	Chronic hepatic failure (HP:0100626)	2.91952036
14	Cystic liver disease (HP:0006706)	2.82750130
15	Abnormal drinking behavior (HP:0030082)	2.76564517
16	Polydipsia (HP:0001959)	2.76564517
17	Abolished electroretinogram (ERG) (HP:0000550)	2.76066572
18	Cerebellar dysplasia (HP:0007033)	2.70587358
19	Attenuation of retinal blood vessels (HP:0007843)	2.60244465
20	Decreased circulating renin level (HP:0003351)	2.55990621
21	Pendular nystagmus (HP:0012043)	2.51577946
22	Lissencephaly (HP:0001339)	2.50592323
23	Congenital, generalized hypertrichosis (HP:0004540)	2.49401837
24	Sclerocornea (HP:0000647)	2.48806616
25	Hyperventilation (HP:0002883)	2.43830036
26	Abnormality of alanine metabolism (HP:0010916)	2.42529837
27	Hyperalaninemia (HP:0003348)	2.42529837
28	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.42529837
29	Polyuria (HP:0000103)	2.39456217
30	Gait imbalance (HP:0002141)	2.33026790
31	Anencephaly (HP:0002323)	2.28419664
32	Metaphyseal dysplasia (HP:0100255)	2.24996462
33	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.23822112
34	Nephrogenic diabetes insipidus (HP:0009806)	2.23503717
35	Congenital primary aphakia (HP:0007707)	2.20838787
36	Abnormal rod and cone electroretinograms (HP:0008323)	2.20507664
37	3-Methylglutaconic aciduria (HP:0003535)	2.18925100
38	Mitochondrial inheritance (HP:0001427)	2.18181498
39	Increased corneal curvature (HP:0100692)	2.17692201
40	Keratoconus (HP:0000563)	2.17692201
41	Abnormal number of erythroid precursors (HP:0012131)	2.17183630
42	Retinal dysplasia (HP:0007973)	2.14594870
43	Renal cortical cysts (HP:0000803)	2.13934994
44	Decreased central vision (HP:0007663)	2.10786270
45	Chorioretinal atrophy (HP:0000533)	2.09745933
46	Asplenia (HP:0001746)	2.08766457
47	Pachygyria (HP:0001302)	2.08235197
48	Absent/shortened dynein arms (HP:0200106)	2.07443011
49	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.07443011
50	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.07132744
51	Methylmalonic acidemia (HP:0002912)	2.06590714
52	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.04964908
53	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.04372405
54	Concave nail (HP:0001598)	2.03481980
55	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.02909282
56	Congenital hepatic fibrosis (HP:0002612)	2.02813355
57	Acute necrotizing encephalopathy (HP:0006965)	2.02377121
58	Increased CSF lactate (HP:0002490)	2.02313978
59	Abnormal pancreas size (HP:0012094)	2.02226764
60	Broad-based gait (HP:0002136)	2.01863904
61	Large for gestational age (HP:0001520)	2.00767562
62	Inability to walk (HP:0002540)	2.00162258
63	Optic disc pallor (HP:0000543)	1.95425930
64	Gaze-evoked nystagmus (HP:0000640)	1.94650887
65	Neoplasm of the adrenal cortex (HP:0100641)	1.94247081
66	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.93974622
67	Abnormal respiratory motile cilium morphology (HP:0005938)	1.92594385
68	Abnormal respiratory epithelium morphology (HP:0012253)	1.92594385
69	Hypoplasia of the uterus (HP:0000013)	1.92337468
70	Abnormal urine output (HP:0012590)	1.92174874
71	Hyperglycinemia (HP:0002154)	1.91935776
72	Congenital sensorineural hearing impairment (HP:0008527)	1.91535644
73	Severe muscular hypotonia (HP:0006829)	1.91062138
74	Hepatocellular necrosis (HP:0001404)	1.89346256
75	Optic nerve hypoplasia (HP:0000609)	1.89225597
76	Bony spicule pigmentary retinopathy (HP:0007737)	1.88385827
77	Abnormal biliary tract physiology (HP:0012439)	1.87099929
78	Bile duct proliferation (HP:0001408)	1.87099929
79	Supernumerary spleens (HP:0009799)	1.86876315
80	Abnormality of cells of the erythroid lineage (HP:0012130)	1.86520397
81	Rib fusion (HP:0000902)	1.85563725
82	Postaxial foot polydactyly (HP:0001830)	1.85004467
83	Male pseudohermaphroditism (HP:0000037)	1.84343984
84	Acute encephalopathy (HP:0006846)	1.84064277
85	Genital tract atresia (HP:0001827)	1.83645245
86	Dandy-Walker malformation (HP:0001305)	1.82823215
87	Abnormality of DNA repair (HP:0003254)	1.81912006
88	Aplasia/hypoplasia of the uterus (HP:0008684)	1.81895432
89	Lipid accumulation in hepatocytes (HP:0006561)	1.81759757
90	Occipital encephalocele (HP:0002085)	1.81487576
91	Colon cancer (HP:0003003)	1.80353499
92	Furrowed tongue (HP:0000221)	1.80145036
93	Abnormal ciliary motility (HP:0012262)	1.79502183
94	Anophthalmia (HP:0000528)	1.77623350
95	Short tibia (HP:0005736)	1.76177297
96	Progressive macrocephaly (HP:0004481)	1.76039301
97	Absent thumb (HP:0009777)	1.75618829
98	Delayed CNS myelination (HP:0002188)	1.75592868
99	Tachypnea (HP:0002789)	1.74832058
100	Genetic anticipation (HP:0003743)	1.74801881

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.20941883
2	ADRBK2	3.22507924
3	BMPR1B	3.21883293
4	WNK4	3.17253182
5	TLK1	2.94578190
6	TXK	2.76523484
7	MAP4K2	2.56137875
8	PINK1	2.54259906
9	ZAK	2.52731759
10	NUAK1	2.47678117
11	INSRR	2.32994701
12	WNK3	2.29929003
13	CASK	2.27266538
14	GRK1	2.20907901
15	ACVR1B	2.16696767
16	MAPK13	1.91672397
17	STK39	1.75477523
18	OXSR1	1.70754269
19	TAOK3	1.64944840
20	MAP2K2	1.53918757
21	TIE1	1.42678740
22	STK16	1.41210518
23	BCKDK	1.40702577
24	DAPK2	1.40348326
25	TNIK	1.39080687
26	TAF1	1.37031712
27	MAP2K6	1.33317481
28	DYRK2	1.24386744
29	ADRBK1	1.15988786
30	MAPK15	1.13633410
31	STK38L	1.10929678
32	NTRK3	1.10880567
33	NTRK2	1.06390624
34	MAPKAPK5	1.05555708
35	MARK1	1.05074787
36	PAK3	0.98997200
37	MAP3K4	0.98648165
38	TGFBR1	0.93463226
39	MAPKAPK3	0.91605088
40	STK11	0.90522434
41	PRKCG	0.89612866
42	SIK2	0.88861680
43	IKBKB	0.88382344
44	VRK2	0.81216934
45	MAP2K7	0.80961679
46	PNCK	0.80508745
47	EPHA3	0.80258208
48	PHKG2	0.79166481
49	PHKG1	0.79166481
50	PRKCE	0.77617894
51	VRK1	0.76643712
52	PRKCQ	0.73325870
53	IKBKE	0.70754651
54	PLK2	0.70562828
55	MKNK2	0.68577716
56	PRKCI	0.66101169
57	MARK3	0.66046963
58	KIT	0.64952324
59	TEC	0.63382697
60	PIK3CA	0.63168361
61	EPHA4	0.62164428
62	NME1	0.61408058
63	ITK	0.59576054
64	CAMKK2	0.59175686
65	CSNK1G2	0.58409604
66	CSNK1G1	0.57379253
67	TRIM28	0.51816476
68	CSNK1G3	0.51234390
69	PRKACA	0.51127420
70	IRAK1	0.50004316
71	PRKD3	0.49967962
72	NLK	0.49793145
73	MUSK	0.49147228
74	CAMK2A	0.48678271
75	PTK2B	0.48660356
76	CSNK1A1	0.47466522
77	CHUK	0.46191206
78	RPS6KA5	0.43866926
79	PRKCZ	0.42451790
80	CSNK1A1L	0.41214616
81	PKN1	0.40136809
82	PLK4	0.39765920
83	MAP2K1	0.39221741
84	FGFR2	0.38851635
85	NEK2	0.38482510
86	GRK7	0.38408260
87	RPS6KA6	0.37989138
88	GRK5	0.37740448
89	OBSCN	0.34944193
90	STK3	0.34755821
91	FLT3	0.34448419
92	CAMK1	0.34088172
93	PRKCH	0.33718229
94	BCR	0.33357659
95	PRKCA	0.31839570
96	IGF1R	0.31107053
97	MKNK1	0.30817648
98	WEE1	0.28337392
99	EIF2AK2	0.27865506
100	SYK	0.27804728

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.18916335
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.89215747
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.60885602
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.59181104
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.47372779
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.34698342
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.21591533
8	Butanoate metabolism_Homo sapiens_hsa00650	2.18998716
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.18332079
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.17728247
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.03344351
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.01122899
13	Selenocompound metabolism_Homo sapiens_hsa00450	1.99719551
14	Tryptophan metabolism_Homo sapiens_hsa00380	1.95277396
15	Parkinsons disease_Homo sapiens_hsa05012	1.90029710
16	Nicotine addiction_Homo sapiens_hsa05033	1.89628232
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.85599839
18	Protein export_Homo sapiens_hsa03060	1.79609408
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.63458499
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.61831732
21	Basal transcription factors_Homo sapiens_hsa03022	1.56929747
22	Morphine addiction_Homo sapiens_hsa05032	1.47761640
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.46906626
24	Taste transduction_Homo sapiens_hsa04742	1.44875305
25	Olfactory transduction_Homo sapiens_hsa04740	1.42529003
26	Ribosome_Homo sapiens_hsa03010	1.42492807
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.36788511
28	Caffeine metabolism_Homo sapiens_hsa00232	1.33943066
29	Homologous recombination_Homo sapiens_hsa03440	1.33539888
30	Cardiac muscle contraction_Homo sapiens_hsa04260	1.32484594
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.28233589
32	Peroxisome_Homo sapiens_hsa04146	1.23608601
33	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.22289816
34	RNA polymerase_Homo sapiens_hsa03020	1.20462156
35	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.19025491
36	Alzheimers disease_Homo sapiens_hsa05010	1.16598771
37	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.13465090
38	Collecting duct acid secretion_Homo sapiens_hsa04966	1.13198921
39	Huntingtons disease_Homo sapiens_hsa05016	1.12343757
40	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.11865557
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.10682997
42	Insulin secretion_Homo sapiens_hsa04911	1.06488555
43	Retinol metabolism_Homo sapiens_hsa00830	1.03295142
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.00679784
45	Circadian entrainment_Homo sapiens_hsa04713	0.98934529
46	Propanoate metabolism_Homo sapiens_hsa00640	0.97954334
47	Serotonergic synapse_Homo sapiens_hsa04726	0.96094793
48	ABC transporters_Homo sapiens_hsa02010	0.95312186
49	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.94449771
50	One carbon pool by folate_Homo sapiens_hsa00670	0.94325167
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.93619884
52	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.92797415
53	Sulfur metabolism_Homo sapiens_hsa00920	0.92179639
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.91125920
55	RNA degradation_Homo sapiens_hsa03018	0.90697852
56	GABAergic synapse_Homo sapiens_hsa04727	0.90565439
57	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.90339319
58	Histidine metabolism_Homo sapiens_hsa00340	0.83535202
59	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.83206939
60	Glutamatergic synapse_Homo sapiens_hsa04724	0.82298071
61	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.81499438
62	Sulfur relay system_Homo sapiens_hsa04122	0.80769570
63	Fat digestion and absorption_Homo sapiens_hsa04975	0.80729021
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.80101627
65	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.72963208
66	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.71332558
67	Primary immunodeficiency_Homo sapiens_hsa05340	0.71041106
68	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.69376159
69	Glycerolipid metabolism_Homo sapiens_hsa00561	0.69329557
70	Calcium signaling pathway_Homo sapiens_hsa04020	0.69063965
71	Regulation of autophagy_Homo sapiens_hsa04140	0.67900588
72	Salivary secretion_Homo sapiens_hsa04970	0.67545940
73	Mineral absorption_Homo sapiens_hsa04978	0.65162441
74	Purine metabolism_Homo sapiens_hsa00230	0.64850338
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.63331785
76	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.59827427
77	Metabolic pathways_Homo sapiens_hsa01100	0.59344013
78	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.56310210
79	Dopaminergic synapse_Homo sapiens_hsa04728	0.55237274
80	Cocaine addiction_Homo sapiens_hsa05030	0.54697244
81	Asthma_Homo sapiens_hsa05310	0.53405660
82	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.52804544
83	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.52597461
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49241653
85	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.49176097
86	Amphetamine addiction_Homo sapiens_hsa05031	0.45651389
87	Fatty acid elongation_Homo sapiens_hsa00062	0.43480788
88	Rheumatoid arthritis_Homo sapiens_hsa05323	0.43190015
89	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.42355582
90	Fatty acid degradation_Homo sapiens_hsa00071	0.41495349
91	Basal cell carcinoma_Homo sapiens_hsa05217	0.39811841
92	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.38554727
93	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.38191776
94	cAMP signaling pathway_Homo sapiens_hsa04024	0.37602633
95	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.37261590
96	Axon guidance_Homo sapiens_hsa04360	0.37252201
97	Long-term depression_Homo sapiens_hsa04730	0.35490130
98	Steroid biosynthesis_Homo sapiens_hsa00100	0.34825567
99	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.34776970
100	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.34228972

OR1AB1P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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