OR1J1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fucose catabolic process (GO:0019317)5.43102100
2L-fucose metabolic process (GO:0042354)5.43102100
3L-fucose catabolic process (GO:0042355)5.43102100
4peptidyl-histidine modification (GO:0018202)5.15432436
5positive regulation of vasculogenesis (GO:2001214)4.77635765
6tryptophan catabolic process (GO:0006569)4.63864933
7indole-containing compound catabolic process (GO:0042436)4.63864933
8indolalkylamine catabolic process (GO:0046218)4.63864933
9amine catabolic process (GO:0009310)4.46683336
10cellular biogenic amine catabolic process (GO:0042402)4.46683336
11regulation of memory T cell differentiation (GO:0043380)4.33323696
12tryptophan metabolic process (GO:0006568)4.28728592
13regulation of MHC class I biosynthetic process (GO:0045343)4.26989633
14platelet dense granule organization (GO:0060155)3.92894290
15indolalkylamine metabolic process (GO:0006586)3.82703966
16cellular ketone body metabolic process (GO:0046950)3.80601800
17microtubule anchoring (GO:0034453)3.76173768
18attachment of spindle microtubules to kinetochore (GO:0008608)3.69110167
19regulation of vasculogenesis (GO:2001212)3.65808681
20DNA integration (GO:0015074)3.61330185
21negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.58657770
22negative regulation of translation, ncRNA-mediated (GO:0040033)3.58657770
23regulation of translation, ncRNA-mediated (GO:0045974)3.58657770
24negative regulation of multicellular organism growth (GO:0040015)3.49731375
25protein K11-linked deubiquitination (GO:0035871)3.49613896
26nucleotide transmembrane transport (GO:1901679)3.47314393
27signal peptide processing (GO:0006465)3.46191517
28regulation of establishment of cell polarity (GO:2000114)3.42758600
29cell wall macromolecule catabolic process (GO:0016998)3.41412182
30aromatic amino acid family catabolic process (GO:0009074)3.37643988
31kynurenine metabolic process (GO:0070189)3.36772578
32regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.34039121
33positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.34039121
34ketone body metabolic process (GO:1902224)3.33012476
35DNA double-strand break processing (GO:0000729)3.28355886
36gamma-aminobutyric acid transport (GO:0015812)3.22434579
37detection of light stimulus involved in sensory perception (GO:0050962)3.22301224
38detection of light stimulus involved in visual perception (GO:0050908)3.22301224
39carnitine transmembrane transport (GO:1902603)3.18160104
40regulation of establishment or maintenance of cell polarity (GO:0032878)3.18085781
41forebrain morphogenesis (GO:0048853)3.17318203
42detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.16628857
43regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.11086268
44piRNA metabolic process (GO:0034587)3.01689117
45production of molecular mediator involved in inflammatory response (GO:0002532)3.01354770
46nonmotile primary cilium assembly (GO:0035058)3.00821556
47S-adenosylmethionine metabolic process (GO:0046500)3.00756500
48rRNA catabolic process (GO:0016075)2.99137355
49glycosphingolipid biosynthetic process (GO:0006688)2.96460767
50photoreceptor cell maintenance (GO:0045494)2.92873442
51carnitine transport (GO:0015879)2.87190566
52amino-acid betaine transport (GO:0015838)2.87190566
53microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.85872916
54cytoplasmic mRNA processing body assembly (GO:0033962)2.83401810
55positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.81992220
56cell wall macromolecule metabolic process (GO:0044036)2.78280511
57sex differentiation (GO:0007548)2.77579804
58RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.77561546
59short-chain fatty acid metabolic process (GO:0046459)2.76508607
60prenylation (GO:0097354)2.75026377
61protein prenylation (GO:0018342)2.75026377
62photoreceptor cell development (GO:0042461)2.74749965
63retinal cone cell development (GO:0046549)2.74442533
64indole-containing compound metabolic process (GO:0042430)2.73103818
65benzene-containing compound metabolic process (GO:0042537)2.73095116
66negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.72511668
67negative regulation of T-helper cell differentiation (GO:0045623)2.72511668
68epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72501146
69cilium morphogenesis (GO:0060271)2.72018627
70transepithelial transport (GO:0070633)2.69865874
71cartilage morphogenesis (GO:0060536)2.69703151
72negative regulation of meiotic cell cycle (GO:0051447)2.68631747
73negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.65931928
74interkinetic nuclear migration (GO:0022027)2.63701032
75establishment of protein localization to Golgi (GO:0072600)2.62795606
76axoneme assembly (GO:0035082)2.62537522
77regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.61507137
78somite rostral/caudal axis specification (GO:0032525)2.61172081
79RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.60979988
80tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.60979988
81centrosome duplication (GO:0051298)2.60466474
82inner ear receptor stereocilium organization (GO:0060122)2.59894254
83motile cilium assembly (GO:0044458)2.58860801
84aromatic amino acid family metabolic process (GO:0009072)2.57308227
85pyrimidine-containing compound transmembrane transport (GO:0072531)2.56575559
86positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.55952599
87neural tube formation (GO:0001841)2.54510270
88heart process (GO:0003015)2.52608800
89heart contraction (GO:0060047)2.52608800
90kidney morphogenesis (GO:0060993)2.51995095
91regulation of action potential (GO:0098900)2.47093207
92adaptation of signaling pathway (GO:0023058)2.44949190
93fucose metabolic process (GO:0006004)2.43379330
94methionine biosynthetic process (GO:0009086)2.42988433
95cilium organization (GO:0044782)2.42173072
96left/right axis specification (GO:0070986)2.41326506
97protein targeting to Golgi (GO:0000042)2.40240677
98negative regulation of mast cell activation (GO:0033004)2.39768256
99negative regulation of organ growth (GO:0046621)2.39672050
100fatty acid transmembrane transport (GO:1902001)2.39219420

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.41336804
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.93636015
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.83318368
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.81516468
5IGF1R_20145208_ChIP-Seq_DFB_Human2.77776202
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.62369978
7VDR_22108803_ChIP-Seq_LS180_Human2.55114421
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.45336091
9GBX2_23144817_ChIP-Seq_PC3_Human2.45027918
10TAF15_26573619_Chip-Seq_HEK293_Human2.40467040
11BCAT_22108803_ChIP-Seq_LS180_Human2.28245167
12FUS_26573619_Chip-Seq_HEK293_Human2.28176268
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16525139
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16215697
15P300_19829295_ChIP-Seq_ESCs_Human2.07306233
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06749617
17AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.05542032
18ER_23166858_ChIP-Seq_MCF-7_Human2.01133889
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95787001
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91322322
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86056464
22EWS_26573619_Chip-Seq_HEK293_Human1.85940489
23NR3C1_21868756_ChIP-Seq_MCF10A_Human1.76565713
24EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.72690953
25SMAD4_21799915_ChIP-Seq_A2780_Human1.72098729
26UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70958435
27POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.68461651
28TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68461651
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65185997
30STAT3_23295773_ChIP-Seq_U87_Human1.61403481
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.60588071
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57361071
33TP53_22573176_ChIP-Seq_HFKS_Human1.54480200
34NANOG_18555785_Chip-Seq_ESCs_Mouse1.52338177
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51967849
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51465376
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.51009882
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50974538
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50459606
40CDX2_22108803_ChIP-Seq_LS180_Human1.50377976
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50144137
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.49248049
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48102767
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46639679
45AR_25329375_ChIP-Seq_VCAP_Human1.43819471
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43084542
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42811779
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.42132250
49KLF5_20875108_ChIP-Seq_MESCs_Mouse1.41025166
50EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40340379
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39992592
52TCF4_23295773_ChIP-Seq_U87_Human1.38000610
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37589708
54CBP_20019798_ChIP-Seq_JUKART_Human1.37589708
55SOX2_19829295_ChIP-Seq_ESCs_Human1.37497494
56NANOG_19829295_ChIP-Seq_ESCs_Human1.37497494
57FLI1_21867929_ChIP-Seq_TH2_Mouse1.36575871
58E2F1_18555785_Chip-Seq_ESCs_Mouse1.34125402
59P53_22387025_ChIP-Seq_ESCs_Mouse1.32729899
60ELK1_19687146_ChIP-ChIP_HELA_Human1.32467897
61CRX_20693478_ChIP-Seq_RETINA_Mouse1.32104466
62TCF4_22108803_ChIP-Seq_LS180_Human1.31280632
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.29589534
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28347299
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26695086
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26367865
67STAT3_18555785_Chip-Seq_ESCs_Mouse1.25619509
68OCT4_21477851_ChIP-Seq_ESCs_Mouse1.24412539
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.23298720
70P300_18555785_Chip-Seq_ESCs_Mouse1.21999278
71RUNX2_22187159_ChIP-Seq_PCA_Human1.21981579
72FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21462430
73SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18548909
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18266900
75FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17458670
76FOXA1_25329375_ChIP-Seq_VCAP_Human1.17458670
77SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16828502
78SMAD4_21741376_ChIP-Seq_EPCs_Human1.14334996
79GABP_17652178_ChIP-ChIP_JURKAT_Human1.14141539
80TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.13983073
81SOX2_18555785_Chip-Seq_ESCs_Mouse1.12827818
82CMYC_18555785_Chip-Seq_ESCs_Mouse1.12468830
83FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11307230
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10396550
85NCOR_22424771_ChIP-Seq_293T_Human1.09788282
86EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09249012
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07259452
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06509174
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03799403
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03799403
91NFYA_21822215_ChIP-Seq_K562_Human1.03044317
92TBL1_22424771_ChIP-Seq_293T_Human1.01382220
93NFYB_21822215_ChIP-Seq_K562_Human1.01313662
94NMYC_18555785_Chip-Seq_ESCs_Mouse1.00907908
95EST1_17652178_ChIP-ChIP_JURKAT_Human1.00303775
96OCT4_18555785_Chip-Seq_ESCs_Mouse1.00128532
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.99507156
98EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99039229
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98928135
100ETV1_20927104_ChIP-Seq_GIST48_Human0.98904197

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.85852551
2MP0000013_abnormal_adipose_tissue3.95382685
3MP0002837_dystrophic_cardiac_calcinosis3.78162655
4MP0003252_abnormal_bile_duct2.38764438
5MP0004043_abnormal_pH_regulation2.37668394
6MP0006082_CNS_inflammation2.13996218
7MP0004145_abnormal_muscle_electrophysio2.13188915
8MP0008789_abnormal_olfactory_epithelium2.12349607
9MP0005551_abnormal_eye_electrophysiolog1.98919683
10MP0005646_abnormal_pituitary_gland1.94259460
11MP0002234_abnormal_pharynx_morphology1.93688140
12MP0001873_stomach_inflammation1.85822470
13MP0004147_increased_porphyrin_level1.85147063
14MP0000538_abnormal_urinary_bladder1.82111367
15MP0006292_abnormal_olfactory_placode1.81825837
16MP0010386_abnormal_urinary_bladder1.79317472
17MP0005645_abnormal_hypothalamus_physiol1.77389285
18MP0008875_abnormal_xenobiotic_pharmacok1.77205208
19MP0000427_abnormal_hair_cycle1.76074665
20MP0000372_irregular_coat_pigmentation1.70705055
21MP0005085_abnormal_gallbladder_physiolo1.69614141
22MP0000569_abnormal_digit_pigmentation1.67631694
23MP0003646_muscle_fatigue1.67065739
24MP0009384_cardiac_valve_regurgitation1.60310878
25MP0003950_abnormal_plasma_membrane1.58282494
26MP0005332_abnormal_amino_acid1.55686933
27MP0005253_abnormal_eye_physiology1.54786716
28MP0008961_abnormal_basal_metabolism1.54105726
29MP0002160_abnormal_reproductive_system1.51767793
30MP0001485_abnormal_pinna_reflex1.48381034
31MP0001764_abnormal_homeostasis1.46335648
32MP0003137_abnormal_impulse_conducting1.45706661
33MP0008057_abnormal_DNA_replication1.37877102
34MP0003172_abnormal_lysosome_physiology1.37160544
35MP0008877_abnormal_DNA_methylation1.37150699
36MP0002102_abnormal_ear_morphology1.35283057
37MP0002938_white_spotting1.35096552
38MP0003195_calcinosis1.33464545
39MP0003186_abnormal_redox_activity1.32768948
40MP0005365_abnormal_bile_salt1.32622381
41MP0008872_abnormal_physiological_respon1.31905936
42MP0006072_abnormal_retinal_apoptosis1.31708728
43MP0001501_abnormal_sleep_pattern1.30280443
44MP0002254_reproductive_system_inflammat1.30168794
45MP0005310_abnormal_salivary_gland1.27984185
46MP0004084_abnormal_cardiac_muscle1.27063502
47MP0002282_abnormal_trachea_morphology1.24747842
48MP0002638_abnormal_pupillary_reflex1.23717398
49MP0003011_delayed_dark_adaptation1.20278383
50MP0003718_maternal_effect1.19584919
51MP0006276_abnormal_autonomic_nervous1.19424418
52MP0005394_taste/olfaction_phenotype1.18906643
53MP0005499_abnormal_olfactory_system1.18906643
54MP0005171_absent_coat_pigmentation1.18759888
55MP0000230_abnormal_systemic_arterial1.18500006
56MP0002909_abnormal_adrenal_gland1.17280521
57MP0001486_abnormal_startle_reflex1.17123548
58MP0002876_abnormal_thyroid_physiology1.16041900
59MP0004215_abnormal_myocardial_fiber1.15910302
60MP0000383_abnormal_hair_follicle1.12225065
61MP0002653_abnormal_ependyma_morphology1.09986070
62MP0002163_abnormal_gland_morphology1.08602454
63MP0001756_abnormal_urination1.07855872
64MP0001968_abnormal_touch/_nociception1.07653006
65MP0005174_abnormal_tail_pigmentation1.07584057
66MP0003937_abnormal_limbs/digits/tail_de1.07302894
67MP0003890_abnormal_embryonic-extraembry1.06544247
68MP0009745_abnormal_behavioral_response1.06017453
69MP0005389_reproductive_system_phenotype1.02921763
70MP0005167_abnormal_blood-brain_barrier1.01910051
71MP0000003_abnormal_adipose_tissue1.01482952
72MP0004885_abnormal_endolymph1.01185559
73MP0002233_abnormal_nose_morphology1.00097507
74MP0004085_abnormal_heartbeat0.98363520
75MP0000631_abnormal_neuroendocrine_gland0.97024111
76MP0010329_abnormal_lipoprotein_level0.94697127
77MP0005220_abnormal_exocrine_pancreas0.93777243
78MP0002272_abnormal_nervous_system0.93326499
79MP0005084_abnormal_gallbladder_morpholo0.91798216
80MP0002736_abnormal_nociception_after0.91284311
81MP0001529_abnormal_vocalization0.90312708
82MP0005636_abnormal_mineral_homeostasis0.89351593
83MP0001270_distended_abdomen0.88930401
84MP0001984_abnormal_olfaction0.88913178
85MP0006054_spinal_hemorrhage0.88313180
86MP0004142_abnormal_muscle_tone0.88039553
87MP0002693_abnormal_pancreas_physiology0.87863234
88MP0001963_abnormal_hearing_physiology0.87035959
89MP0002009_preneoplasia0.86556500
90MP0005379_endocrine/exocrine_gland_phen0.85425683
91MP0005670_abnormal_white_adipose0.84275904
92MP0000470_abnormal_stomach_morphology0.81982508
93MP0000653_abnormal_sex_gland0.80275615
94MP0010678_abnormal_skin_adnexa0.80237987
95MP0001944_abnormal_pancreas_morphology0.80159885
96MP0004134_abnormal_chest_morphology0.77464078
97MP0001661_extended_life_span0.77377482
98MP0005410_abnormal_fertilization0.77370783
99MP0000026_abnormal_inner_ear0.76538502
100MP0002928_abnormal_bile_duct0.75209370

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the renal cortex (HP:0011035)4.14366854
2Pancreatic cysts (HP:0001737)3.86413211
3Genetic anticipation (HP:0003743)3.62987125
4Abnormality of midbrain morphology (HP:0002418)3.62036791
5Molar tooth sign on MRI (HP:0002419)3.62036791
6Abnormal rod and cone electroretinograms (HP:0008323)3.56806825
7Pancreatic fibrosis (HP:0100732)3.48740062
8Absent rod-and cone-mediated responses on ERG (HP:0007688)3.44241832
9Renal cortical cysts (HP:0000803)3.41668073
10True hermaphroditism (HP:0010459)3.41631159
11Hepatic necrosis (HP:0002605)3.40876984
12Attenuation of retinal blood vessels (HP:0007843)3.27678057
13Progressive cerebellar ataxia (HP:0002073)3.23750880
14Gaze-evoked nystagmus (HP:0000640)3.10124521
15Abnormality of the renal medulla (HP:0100957)3.02999573
16Type II lissencephaly (HP:0007260)3.01149952
17Hepatocellular necrosis (HP:0001404)3.00626840
18Nephronophthisis (HP:0000090)2.93075761
19Cerebellar dysplasia (HP:0007033)2.90458043
20Tubular atrophy (HP:0000092)2.77140534
21Proximal tubulopathy (HP:0000114)2.72007176
22Progressive macrocephaly (HP:0004481)2.67997665
23Acute necrotizing encephalopathy (HP:0006965)2.62010029
24Decreased central vision (HP:0007663)2.57090138
25Generalized aminoaciduria (HP:0002909)2.56038518
26Dyskinesia (HP:0100660)2.55244350
27Polydipsia (HP:0001959)2.53050217
28Abnormal drinking behavior (HP:0030082)2.53050217
29Abnormality of the corticospinal tract (HP:0002492)2.52667788
30Medial flaring of the eyebrow (HP:0010747)2.49604798
31Arthropathy (HP:0003040)2.47135809
32Abnormal biliary tract physiology (HP:0012439)2.46712476
33Bile duct proliferation (HP:0001408)2.46712476
34Abolished electroretinogram (ERG) (HP:0000550)2.35780279
35Keratoconus (HP:0000563)2.35039309
36Increased corneal curvature (HP:0100692)2.35039309
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.31804729
38Dyschromatopsia (HP:0007641)2.30689404
39Congenital stationary night blindness (HP:0007642)2.30552418
40Cystic liver disease (HP:0006706)2.29866427
41Congenital, generalized hypertrichosis (HP:0004540)2.29370626
42Neonatal respiratory distress (HP:0002643)2.28374134
43Severe muscular hypotonia (HP:0006829)2.28349890
44Bony spicule pigmentary retinopathy (HP:0007737)2.28215491
45Pendular nystagmus (HP:0012043)2.26162542
46Furrowed tongue (HP:0000221)2.25935650
47Large for gestational age (HP:0001520)2.24796377
48Prominent supraorbital ridges (HP:0000336)2.21647901
49Chronic hepatic failure (HP:0100626)2.19886743
50Abnormality of urine glucose concentration (HP:0011016)2.19632639
51Glycosuria (HP:0003076)2.19632639
52Mitochondrial inheritance (HP:0001427)2.18182229
53Abnormality of macular pigmentation (HP:0008002)2.16894128
54Increased CSF lactate (HP:0002490)2.13312788
55Polyuria (HP:0000103)2.12380582
56Acute encephalopathy (HP:0006846)2.11368197
57Hypokalemic alkalosis (HP:0001949)2.11334799
58Abnormality of the lower motor neuron (HP:0002366)2.10743094
59Abnormal mitochondria in muscle tissue (HP:0008316)2.07339566
60Hypothermia (HP:0002045)2.07231414
61Abnormal hemoglobin (HP:0011902)2.06348340
62Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96263304
63Optic disc pallor (HP:0000543)1.95178949
64Aplasia/Hypoplasia of the tongue (HP:0010295)1.94447988
65Urinary bladder sphincter dysfunction (HP:0002839)1.93823262
66Abnormality of the prostate (HP:0008775)1.93779071
67Hemiparesis (HP:0001269)1.93045659
68Hyperventilation (HP:0002883)1.92585694
69Hypoplastic ischia (HP:0003175)1.91838254
70Sloping forehead (HP:0000340)1.91268597
71Hypoplasia of the pons (HP:0012110)1.91056495
72Severe visual impairment (HP:0001141)1.89083645
73Impaired vibratory sensation (HP:0002495)1.88284064
74Chorioretinal atrophy (HP:0000533)1.83214252
75Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.82756540
76Hypoglycemic coma (HP:0001325)1.82524910
77Chromsome breakage (HP:0040012)1.81111703
78Tubulointerstitial abnormality (HP:0001969)1.80274653
79Abnormal biliary tract morphology (HP:0012440)1.79440876
80Sclerocornea (HP:0000647)1.79156719
81Meckel diverticulum (HP:0002245)1.79138506
82Hand muscle atrophy (HP:0009130)1.78248331
83Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78180616
84Abnormality of the ileum (HP:0001549)1.77822317
85Biliary tract neoplasm (HP:0100574)1.73225778
86Dysdiadochokinesis (HP:0002075)1.73077030
87Febrile seizures (HP:0002373)1.72715664
88Prostate neoplasm (HP:0100787)1.72531089
89Tubulointerstitial nephritis (HP:0001970)1.71397735
90Action tremor (HP:0002345)1.71170327
91Left ventricular hypertrophy (HP:0001712)1.71050156
92Intestinal atresia (HP:0011100)1.70554205
93Male pseudohermaphroditism (HP:0000037)1.69184353
94Cerebral edema (HP:0002181)1.69121809
95Absent speech (HP:0001344)1.68316445
96Lissencephaly (HP:0001339)1.68118309
97Lipid accumulation in hepatocytes (HP:0006561)1.67126278
98Vitreoretinal degeneration (HP:0000655)1.66746248
99Abnormality of chromosome stability (HP:0003220)1.65181792
100Constricted visual fields (HP:0001133)1.64467700

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.06455786
2BMPR1B4.76488771
3MAP4K24.44931542
4STK393.88387402
5OXSR13.43576709
6GRK12.48073929
7STK38L2.30741698
8MUSK2.23098786
9WNK42.22659832
10ADRBK22.17536883
11NEK12.08694140
12VRK21.95858692
13MKNK21.87862284
14MKNK11.80113492
15NUAK11.76807580
16CCNB11.75706170
17STK31.74838552
18ACVR1B1.65452270
19TGFBR11.46439592
20PINK11.42630682
21ZAK1.41707739
22TNK21.41017201
23TEC1.36758114
24FLT31.28793217
25CDK191.27654743
26BMPR21.26297782
27PRKCE1.25421494
28PIK3CG1.19055936
29WNK31.13296541
30INSRR1.11803191
31TIE11.10587867
32CDK81.03860671
33PKN21.02499578
34TNIK1.00691970
35ITK0.99571683
36TRIM280.97657364
37ERBB30.97025524
38LATS10.89811366
39MAPK130.88818567
40TAOK30.87532692
41MAP3K70.82998955
42EIF2AK30.82777123
43PRKD30.78806078
44IRAK10.71687154
45MAP3K40.66964710
46EPHA30.66196164
47CASK0.64754342
48ADRBK10.62821959
49VRK10.62146534
50CDK90.60643865
51PRKG20.59466313
52BCKDK0.57036044
53BTK0.56882828
54PBK0.55429152
55NME10.54647428
56PDK20.52459075
57SRPK10.47938021
58PRKG10.47924512
59PHKG10.47326933
60PHKG20.47326933
61FGFR20.47096952
62FER0.46017757
63SYK0.45895748
64TRPM70.45804053
65CSNK1G30.44998907
66CSNK1G10.44978512
67PRKCQ0.44705371
68CSNK1G20.44533774
69NTRK20.43990970
70BCR0.43202237
71TAF10.42619353
72ABL10.41746559
73OBSCN0.41184094
74PKN10.41167571
75MAPKAPK50.40386443
76PRKCG0.40250437
77PIK3CA0.39069514
78STK40.38030649
79DAPK20.37708171
80STK380.37669764
81CSNK1D0.37168567
82PTK2B0.36760932
83MAP2K60.36636520
84EPHA40.36555162
85CDK30.33794431
86EIF2AK20.32876598
87IKBKB0.31456398
88PAK30.30142640
89STK110.30055228
90CSNK1A1L0.28753295
91PRKAA10.27660955
92PRKACA0.27234650
93RPS6KA40.27123791
94RIPK40.26909495
95LIMK10.25754255
96GRK50.25329176
97MST40.24803005
98CSNK2A10.24270656
99RPS6KA50.23920838
100ATM0.22806507

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.38842742
2Butanoate metabolism_Homo sapiens_hsa006504.03140795
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.12012361
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.71440583
5Caffeine metabolism_Homo sapiens_hsa002322.60622992
6Sulfur metabolism_Homo sapiens_hsa009202.52042815
7Propanoate metabolism_Homo sapiens_hsa006402.42979384
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.28840066
9Tryptophan metabolism_Homo sapiens_hsa003802.19270332
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.07204603
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.01773262
12Ether lipid metabolism_Homo sapiens_hsa005651.94540226
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.86426244
14Phototransduction_Homo sapiens_hsa047441.81487214
15Linoleic acid metabolism_Homo sapiens_hsa005911.78967875
16Protein export_Homo sapiens_hsa030601.76733428
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.73457882
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.64982724
19RNA polymerase_Homo sapiens_hsa030201.62590019
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60363441
21beta-Alanine metabolism_Homo sapiens_hsa004101.57217488
22Taste transduction_Homo sapiens_hsa047421.53969859
23Fanconi anemia pathway_Homo sapiens_hsa034601.43990032
24* Olfactory transduction_Homo sapiens_hsa047401.32140155
25Fatty acid degradation_Homo sapiens_hsa000711.29812289
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26105298
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22672936
28Basal transcription factors_Homo sapiens_hsa030221.21225520
29Asthma_Homo sapiens_hsa053101.19067311
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.13495944
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13252443
32Nitrogen metabolism_Homo sapiens_hsa009101.10874673
33Retinol metabolism_Homo sapiens_hsa008301.09681047
34RNA degradation_Homo sapiens_hsa030181.09101371
35Circadian rhythm_Homo sapiens_hsa047101.08114385
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.07496153
37GABAergic synapse_Homo sapiens_hsa047271.06949866
38Mineral absorption_Homo sapiens_hsa049781.06428401
39Salivary secretion_Homo sapiens_hsa049701.03821828
40Oxidative phosphorylation_Homo sapiens_hsa001901.02186956
41Morphine addiction_Homo sapiens_hsa050321.00972274
42Nicotine addiction_Homo sapiens_hsa050330.99256935
43Glycosaminoglycan degradation_Homo sapiens_hsa005310.96171186
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92149504
45Glycerolipid metabolism_Homo sapiens_hsa005610.90169027
46Parkinsons disease_Homo sapiens_hsa050120.89980251
47Chemical carcinogenesis_Homo sapiens_hsa052040.86312893
48Peroxisome_Homo sapiens_hsa041460.85615311
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85395183
50Arachidonic acid metabolism_Homo sapiens_hsa005900.82327127
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82074380
52ABC transporters_Homo sapiens_hsa020100.81816872
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80954921
54Homologous recombination_Homo sapiens_hsa034400.80927083
55Ovarian steroidogenesis_Homo sapiens_hsa049130.78297423
56Insulin secretion_Homo sapiens_hsa049110.77869129
57Glutamatergic synapse_Homo sapiens_hsa047240.76827359
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.74529815
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73935679
60Circadian entrainment_Homo sapiens_hsa047130.73405884
61One carbon pool by folate_Homo sapiens_hsa006700.70151482
62Fatty acid biosynthesis_Homo sapiens_hsa000610.68658234
63Vitamin B6 metabolism_Homo sapiens_hsa007500.67952735
64Serotonergic synapse_Homo sapiens_hsa047260.66057223
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.63979499
66Lysine degradation_Homo sapiens_hsa003100.61507182
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61086577
68Histidine metabolism_Homo sapiens_hsa003400.59982013
69Metabolic pathways_Homo sapiens_hsa011000.57938273
70Hedgehog signaling pathway_Homo sapiens_hsa043400.57483518
71Non-homologous end-joining_Homo sapiens_hsa034500.56432187
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56291738
73Renin secretion_Homo sapiens_hsa049240.55247846
74Selenocompound metabolism_Homo sapiens_hsa004500.52235537
75Fatty acid metabolism_Homo sapiens_hsa012120.51538609
76Pyruvate metabolism_Homo sapiens_hsa006200.51535059
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51368472
78Purine metabolism_Homo sapiens_hsa002300.49330866
79TGF-beta signaling pathway_Homo sapiens_hsa043500.48732312
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48705529
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47687888
82Sphingolipid metabolism_Homo sapiens_hsa006000.47410659
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.47142115
84Calcium signaling pathway_Homo sapiens_hsa040200.45884366
85PPAR signaling pathway_Homo sapiens_hsa033200.45852478
86Amphetamine addiction_Homo sapiens_hsa050310.43238277
87Vitamin digestion and absorption_Homo sapiens_hsa049770.41362695
88African trypanosomiasis_Homo sapiens_hsa051430.40013572
89Pancreatic secretion_Homo sapiens_hsa049720.39668364
90Huntingtons disease_Homo sapiens_hsa050160.37551392
91Thyroid hormone synthesis_Homo sapiens_hsa049180.36439221
92Dopaminergic synapse_Homo sapiens_hsa047280.36191108
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35223551
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34139025
95Folate biosynthesis_Homo sapiens_hsa007900.34056548
96Pyrimidine metabolism_Homo sapiens_hsa002400.33537240
97Fat digestion and absorption_Homo sapiens_hsa049750.33217396
98Allograft rejection_Homo sapiens_hsa053300.33146331
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33141336
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.29755966

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