OR1R1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)8.29940046
2sleep (GO:0030431)8.00662467
3fusion of sperm to egg plasma membrane (GO:0007342)7.26958760
4plasma membrane fusion (GO:0045026)6.14916091
5male sex determination (GO:0030238)5.67521145
6deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.60654691
7gonadal mesoderm development (GO:0007506)5.53110976
8sperm motility (GO:0030317)5.51275112
9spermatid development (GO:0007286)5.48829065
10multicellular organism reproduction (GO:0032504)5.35502463
11DNA methylation involved in gamete generation (GO:0043046)5.34250089
12male meiosis (GO:0007140)5.33419483
13detection of chemical stimulus involved in sensory perception of smell (GO:0050911)5.30479789
14rRNA methylation (GO:0031167)5.11945904
15rRNA modification (GO:0000154)4.99770357
16adenosine metabolic process (GO:0046085)4.97873792
17male meiosis I (GO:0007141)4.91422198
18mast cell degranulation (GO:0043303)4.85274270
19mast cell activation involved in immune response (GO:0002279)4.85274270
20reproduction (GO:0000003)4.67273923
21regulation of cilium movement (GO:0003352)4.67102533
22acrosome reaction (GO:0007340)4.48710520
23cilium or flagellum-dependent cell motility (GO:0001539)4.36211356
24sperm-egg recognition (GO:0035036)4.09035927
25tolerance induction (GO:0002507)3.96611534
26cellular response to prostaglandin stimulus (GO:0071379)3.80040543
27meiosis I (GO:0007127)3.70911497
28meiotic nuclear division (GO:0007126)3.61187954
29histone exchange (GO:0043486)3.59445983
30binding of sperm to zona pellucida (GO:0007339)3.56355803
31lymph vessel development (GO:0001945)3.56333289
32positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.53553437
33regulation of B cell receptor signaling pathway (GO:0050855)3.53320232
34centriole assembly (GO:0098534)3.52715409
35germ cell development (GO:0007281)3.47445657
36sexual reproduction (GO:0019953)3.47347712
37regulation of mast cell degranulation (GO:0043304)3.43187843
38single fertilization (GO:0007338)3.41438067
39cell-cell recognition (GO:0009988)3.36733472
40regulation of mast cell activation involved in immune response (GO:0033006)3.35205200
41positive regulation of catecholamine secretion (GO:0033605)3.34536778
42interkinetic nuclear migration (GO:0022027)3.33842138
43axonemal dynein complex assembly (GO:0070286)3.30476191
44motile cilium assembly (GO:0044458)3.29043148
45mast cell activation (GO:0045576)3.27935875
46somatic diversification of immune receptors via somatic mutation (GO:0002566)3.25039408
47somatic hypermutation of immunoglobulin genes (GO:0016446)3.25039408
48sex determination (GO:0007530)3.24291454
49synapsis (GO:0007129)3.22933167
50regulation of phosphoprotein phosphatase activity (GO:0043666)3.22902325
51regulation of microtubule-based movement (GO:0060632)3.20262956
52detection of chemical stimulus involved in sensory perception (GO:0050907)3.19259198
53lysosome localization (GO:0032418)3.18483825
54leukocyte degranulation (GO:0043299)3.15096946
55regulation of germinal center formation (GO:0002634)3.14178542
56positive regulation of megakaryocyte differentiation (GO:0045654)3.11991559
57negative regulation of T cell apoptotic process (GO:0070233)3.11063321
58natural killer cell activation involved in immune response (GO:0002323)3.03954279
59response to pheromone (GO:0019236)3.03899328
60epithelial cilium movement (GO:0003351)3.02944532
61positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.02533692
62regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.02533692
63RNA destabilization (GO:0050779)2.99997889
64synaptonemal complex assembly (GO:0007130)2.99589290
65fertilization (GO:0009566)2.99269579
66regulation of oxidative phosphorylation (GO:0002082)2.99264369
67negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.98805892
68positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.98780425
69chromosome organization involved in meiosis (GO:0070192)2.98637973
70DNA strand elongation involved in DNA replication (GO:0006271)2.91648875
71pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.91457986
72Peyers patch development (GO:0048541)2.89105483
73mucosal-associated lymphoid tissue development (GO:0048537)2.89105483
74protein-DNA complex disassembly (GO:0032986)2.88649769
75nucleosome disassembly (GO:0006337)2.88649769
76oogenesis (GO:0048477)2.88530692
77acrosome assembly (GO:0001675)2.87448432
78centriole replication (GO:0007099)2.87027333
79negative regulation of necroptotic process (GO:0060546)2.86108292
80response to muramyl dipeptide (GO:0032495)2.82820562
81gene silencing by RNA (GO:0031047)2.79582890
82endothelium development (GO:0003158)2.78692849
83DNA strand elongation (GO:0022616)2.75313569
84dosage compensation (GO:0007549)2.73797499
85DNA deamination (GO:0045006)2.71511660
86DNA replication-dependent nucleosome organization (GO:0034723)2.70824235
87DNA replication-dependent nucleosome assembly (GO:0006335)2.70824235
88face development (GO:0060324)2.69824090
89ubiquinone biosynthetic process (GO:0006744)2.69393714
90regulation of mast cell activation (GO:0033003)2.69265184
91telomere maintenance via semi-conservative replication (GO:0032201)2.66590633
92negative regulation of interleukin-1 beta production (GO:0032691)2.64516614
93microtubule depolymerization (GO:0007019)2.63197244
94cellular process involved in reproduction in multicellular organism (GO:0022412)2.63092903
95organic cation transport (GO:0015695)2.62900062
96positive regulation of T cell mediated cytotoxicity (GO:0001916)2.56118427
97definitive hemopoiesis (GO:0060216)2.54997372
98negative regulation of Notch signaling pathway (GO:0045746)2.54200417
99synaptonemal complex organization (GO:0070193)2.54199195
100seminiferous tubule development (GO:0072520)2.52162194

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.64897732
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.27252296
3IGF1R_20145208_ChIP-Seq_DFB_Human4.38194775
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.31415958
5E2F7_22180533_ChIP-Seq_HELA_Human3.82456032
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.52432205
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.21970723
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.83279493
9SCL_19346495_ChIP-Seq_HPC-7_Human2.79807082
10VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.70106228
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.64433277
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.59453256
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20654517
14CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.08294088
15ZNF274_21170338_ChIP-Seq_K562_Hela2.08283714
16RUNX_20019798_ChIP-Seq_JUKART_Human1.97242486
17EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.91942614
18IRF8_21731497_ChIP-ChIP_J774_Mouse1.85769143
19NANOG_20526341_ChIP-Seq_ESCs_Human1.85263197
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80543241
21BCL6_27268052_Chip-Seq_Bcells_Human1.79724607
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.79373801
23IRF1_19129219_ChIP-ChIP_H3396_Human1.74275222
24RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.74091011
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.69443571
26ERA_21632823_ChIP-Seq_H3396_Human1.69353931
27P300_27268052_Chip-Seq_Bcells_Human1.68545648
28ELF1_20517297_ChIP-Seq_JURKAT_Human1.65606673
29VDR_23849224_ChIP-Seq_CD4+_Human1.61762542
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.60959230
31PHF8_20622854_ChIP-Seq_HELA_Human1.51810915
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51236880
33SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48928073
34SPI1_23547873_ChIP-Seq_NB4_Human1.46252648
35MYB_26560356_Chip-Seq_TH2_Human1.45457104
36FOXP3_21729870_ChIP-Seq_TREG_Human1.45042922
37RAC3_21632823_ChIP-Seq_H3396_Human1.43814689
38GATA3_26560356_Chip-Seq_TH2_Human1.42230464
39E2F1_20622854_ChIP-Seq_HELA_Human1.40973518
40PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.37996399
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37388611
42ER_23166858_ChIP-Seq_MCF-7_Human1.36894076
43GATA3_27048872_Chip-Seq_THYMUS_Human1.34831077
44ERG_20517297_ChIP-Seq_VCAP_Human1.33977645
45CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.33915896
46CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.33888128
47P68_20966046_ChIP-Seq_HELA_Human1.32645026
48SPI1_20517297_ChIP-Seq_HL60_Human1.32247684
49WDR5_24793694_ChIP-Seq_LNCAP_Human1.31734179
50STAT1_20625510_ChIP-Seq_HELA_Human1.28069080
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25295464
52OCT4_20526341_ChIP-Seq_ESCs_Human1.23864963
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22625362
54MYB_26560356_Chip-Seq_TH1_Human1.22544108
55MAF_26560356_Chip-Seq_TH2_Human1.21823995
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20976781
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19541957
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.17700810
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15754715
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15707991
61YY1_22570637_ChIP-Seq_MALME-3M_Human1.15501789
62CBP_20019798_ChIP-Seq_JUKART_Human1.12773353
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12773353
64UTX_26944678_Chip-Seq_JUKART_Human1.11160866
65CTCF_20526341_ChIP-Seq_ESCs_Human1.10288311
66FUS_26573619_Chip-Seq_HEK293_Human1.09540180
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09279610
68CTCF_21964334_ChIP-Seq_BJAB-B_Human1.07597518
69MYC_19829295_ChIP-Seq_ESCs_Human1.06621171
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.06103437
71MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05855188
72EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05708332
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04181858
74OCT1_27270436_Chip-Seq_PROSTATE_Human1.03834734
75FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02750546
76MYC_18555785_ChIP-Seq_MESCs_Mouse1.01838928
77IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00886252
78BCOR_27268052_Chip-Seq_Bcells_Human1.00862992
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00052135
80GABP_19822575_ChIP-Seq_HepG2_Human0.99863632
81HOXB7_26014856_ChIP-Seq_BT474_Human0.99089418
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97586232
83FOXH1_21741376_ChIP-Seq_EPCs_Human0.96177631
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94746029
85CTCF_21964334_Chip-Seq_Bcells_Human0.94705905
86GATA3_26560356_Chip-Seq_TH1_Human0.94239003
87ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94176826
88TP63_19390658_ChIP-ChIP_HaCaT_Human0.93647342
89KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.93165348
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92451442
91GATA3_21878914_ChIP-Seq_MCF-7_Human0.91950968
92CIITA_25753668_ChIP-Seq_RAJI_Human0.91570143
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91534784
94ETS1_20019798_ChIP-Seq_JURKAT_Human0.91067759
95RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89622863
96CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89557436
97GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89350775
98RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88349721
99SRF_21415370_ChIP-Seq_HL-1_Mouse0.87025446
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86838111

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.77891605
2MP0000465_gastrointestinal_hemorrhage4.83361976
3MP0002160_abnormal_reproductive_system3.39737712
4MP0008058_abnormal_DNA_repair3.06616864
5MP0001929_abnormal_gametogenesis2.78278317
6MP0002876_abnormal_thyroid_physiology2.75045242
7MP0003698_abnormal_male_reproductive2.71636006
8MP0003183_abnormal_peptide_metabolism2.58962584
9MP0003724_increased_susceptibility_to2.50404719
10MP0010368_abnormal_lymphatic_system2.50082034
11MP0005646_abnormal_pituitary_gland2.47084710
12MP0004147_increased_porphyrin_level2.37924640
13MP0010094_abnormal_chromosome_stability2.33884321
14MP0008004_abnormal_stomach_pH2.30246304
15MP0008877_abnormal_DNA_methylation2.27730517
16MP0002254_reproductive_system_inflammat2.27456830
17MP0001879_abnormal_lymphatic_vessel2.18950509
18MP0003763_abnormal_thymus_physiology2.12536126
19MP0003436_decreased_susceptibility_to2.07021203
20MP0005389_reproductive_system_phenotype1.92112295
21MP0002210_abnormal_sex_determination1.82058713
22MP0001145_abnormal_male_reproductive1.78167779
23MP0004145_abnormal_muscle_electrophysio1.70955553
24MP0000653_abnormal_sex_gland1.67721521
25MP0008789_abnormal_olfactory_epithelium1.66807195
26MP0003315_abnormal_perineum_morphology1.64354872
27MP0005499_abnormal_olfactory_system1.63193001
28MP0005394_taste/olfaction_phenotype1.63193001
29MP0002132_abnormal_respiratory_system1.61670515
30MP0005084_abnormal_gallbladder_morpholo1.61581145
31MP0005000_abnormal_immune_tolerance1.59495271
32MP0005075_abnormal_melanosome_morpholog1.58982786
33MP0003718_maternal_effect1.54280126
34MP0002405_respiratory_system_inflammati1.48527506
35MP0009379_abnormal_foot_pigmentation1.44746973
36MP0002161_abnormal_fertility/fecundity1.42006561
37MP0005671_abnormal_response_to1.40661695
38MP0005360_urolithiasis1.40358161
39MP0001984_abnormal_olfaction1.39274823
40MP0005647_abnormal_sex_gland1.31029498
41MP0009278_abnormal_bone_marrow1.29884256
42MP0005174_abnormal_tail_pigmentation1.27936221
43MP0002398_abnormal_bone_marrow1.27322141
44MP0006036_abnormal_mitochondrial_physio1.25993828
45MP0002722_abnormal_immune_system1.25308970
46MP0002723_abnormal_immune_serum1.23049201
47MP0000703_abnormal_thymus_morphology1.22930076
48MP0001819_abnormal_immune_cell1.21562048
49MP0001835_abnormal_antigen_presentation1.19720925
50MP0002420_abnormal_adaptive_immunity1.18229229
51MP0006292_abnormal_olfactory_placode1.17009555
52MP0001188_hyperpigmentation1.16696332
53MP0005464_abnormal_platelet_physiology1.16640999
54MP0001501_abnormal_sleep_pattern1.15789670
55MP0000716_abnormal_immune_system1.09811778
56MP0005397_hematopoietic_system_phenotyp1.09502090
57MP0001545_abnormal_hematopoietic_system1.09502090
58MP0000689_abnormal_spleen_morphology1.09017530
59MP0009785_altered_susceptibility_to1.06499485
60MP0002452_abnormal_antigen_presenting1.04186146
61MP0002419_abnormal_innate_immunity1.03296494
62MP0002148_abnormal_hypersensitivity_rea1.02967009
63MP0001986_abnormal_taste_sensitivity1.01839012
64MP0000685_abnormal_immune_system1.00816239
65MP0010307_abnormal_tumor_latency0.99768392
66MP0002933_joint_inflammation0.98641527
67MP0001853_heart_inflammation0.97897751
68MP0005395_other_phenotype0.97184497
69MP0001800_abnormal_humoral_immune0.95522921
70MP0005025_abnormal_response_to0.94765717
71MP0000681_abnormal_thyroid_gland0.94549127
72MP0002429_abnormal_blood_cell0.94332695
73MP0003045_fibrosis0.92642781
74MP0006072_abnormal_retinal_apoptosis0.92586199
75MP0004133_heterotaxia0.90308592
76MP0008995_early_reproductive_senescence0.89184077
77MP0001851_eye_inflammation0.86097440
78MP0001919_abnormal_reproductive_system0.83817744
79MP0001119_abnormal_female_reproductive0.82563670
80MP0005645_abnormal_hypothalamus_physiol0.82379359
81MP0005670_abnormal_white_adipose0.81904491
82MP0003828_pulmonary_edema0.81210414
83MP0009697_abnormal_copulation0.79001821
84MP0002735_abnormal_chemical_nociception0.78659860
85MP0001765_abnormal_ion_homeostasis0.78391957
86MP0003077_abnormal_cell_cycle0.78391126
87MP0002019_abnormal_tumor_incidence0.78293682
88MP0005167_abnormal_blood-brain_barrier0.77476084
89MP0003075_altered_response_to0.75170312
90MP0002102_abnormal_ear_morphology0.74521636
91MP0008872_abnormal_physiological_respon0.72122796
92MP0000015_abnormal_ear_pigmentation0.71887715
93MP0005377_hearing/vestibular/ear_phenot0.71878615
94MP0003878_abnormal_ear_physiology0.71878615
95MP0002249_abnormal_larynx_morphology0.71711664
96MP0001533_abnormal_skeleton_physiology0.71022776
97MP0010155_abnormal_intestine_physiology0.69137418
98MP0003656_abnormal_erythrocyte_physiolo0.68611221
99MP0002282_abnormal_trachea_morphology0.67578636
100MP0001905_abnormal_dopamine_level0.67283599

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)4.16902329
2Abnormal protein glycosylation (HP:0012346)3.83912202
3Abnormal glycosylation (HP:0012345)3.83912202
4Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.83912202
5Abnormal protein N-linked glycosylation (HP:0012347)3.83912202
6Abnormality of B cell number (HP:0010975)3.81734782
7Panhypogammaglobulinemia (HP:0003139)3.44893595
8Elevated erythrocyte sedimentation rate (HP:0003565)3.44681630
9Cerebellar dysplasia (HP:0007033)3.36943130
10Hypoplasia of the pons (HP:0012110)3.36679435
11Stomatitis (HP:0010280)3.33678967
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.29821537
13Absent/shortened dynein arms (HP:0200106)3.29821537
14Severe combined immunodeficiency (HP:0004430)3.26458130
15Abnormality of male internal genitalia (HP:0000022)3.22533666
16Reduced antithrombin III activity (HP:0001976)3.20569254
17Abnormality of the prostate (HP:0008775)3.19104502
18Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.07370772
19Hypoplasia of the uterus (HP:0000013)3.00585107
20Abnormal spermatogenesis (HP:0008669)2.93199573
21Male infertility (HP:0003251)2.91183025
22Median cleft lip (HP:0000161)2.89001199
23Abnormality of alanine metabolism (HP:0010916)2.88646776
24Hyperalaninemia (HP:0003348)2.88646776
25Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.88646776
26Gonadal dysgenesis (HP:0000133)2.86516887
27Fatigue (HP:0012378)2.82243879
28Type I transferrin isoform profile (HP:0003642)2.80200700
29Combined immunodeficiency (HP:0005387)2.73736134
30Abnormality of the pons (HP:0007361)2.73080271
31Infertility (HP:0000789)2.65437282
32Abnormal rod and cone electroretinograms (HP:0008323)2.63733273
33Abnormality of the columella (HP:0009929)2.61773965
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.61292102
35Visual hallucinations (HP:0002367)2.59637661
36Absent thumb (HP:0009777)2.57427878
37Reticulocytopenia (HP:0001896)2.49946995
38Colitis (HP:0002583)2.49753836
39Type II lissencephaly (HP:0007260)2.49617367
40Abnormal respiratory motile cilium physiology (HP:0012261)2.49104253
41Recurrent fungal infections (HP:0002841)2.47614743
42Focal motor seizures (HP:0011153)2.46996867
43Chronic obstructive pulmonary disease (HP:0006510)2.45357838
44Obstructive lung disease (HP:0006536)2.45357838
45Short middle phalanx of the 5th finger (HP:0004220)2.41130785
46IgG deficiency (HP:0004315)2.39485082
47Clumsiness (HP:0002312)2.39152724
48Pulmonary fibrosis (HP:0002206)2.35596645
49Inflammation of the large intestine (HP:0002037)2.34757114
50Duplication of thumb phalanx (HP:0009942)2.32079289
51Abnormal ciliary motility (HP:0012262)2.30876760
52Chromsome breakage (HP:0040012)2.28694654
53Abnormal respiratory epithelium morphology (HP:0012253)2.28178142
54Abnormal respiratory motile cilium morphology (HP:0005938)2.28178142
55Abnormality of T cell physiology (HP:0011840)2.25034290
563-Methylglutaconic aciduria (HP:0003535)2.23635478
57Tubulointerstitial nephritis (HP:0001970)2.22961509
58Absent rod-and cone-mediated responses on ERG (HP:0007688)2.21799549
59Sensory axonal neuropathy (HP:0003390)2.18727243
60Gastrointestinal inflammation (HP:0004386)2.16688556
61Recurrent sinusitis (HP:0011108)2.14112184
62Agammaglobulinemia (HP:0004432)2.12520767
63Thoracic kyphosis (HP:0002942)2.12318910
64Resting tremor (HP:0002322)2.10447953
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.10417323
66Metaphyseal dysplasia (HP:0100255)2.09407865
67Pancytopenia (HP:0001876)2.08857061
68Abnormality of DNA repair (HP:0003254)2.05856327
69Aplasia/hypoplasia of the uterus (HP:0008684)2.02647563
70Polyneuropathy (HP:0001271)2.01562693
71Atonic seizures (HP:0010819)1.99992401
72Poor head control (HP:0002421)1.99077868
73Abnormality of macular pigmentation (HP:0008002)1.98267038
74Autoimmune hemolytic anemia (HP:0001890)1.97628906
75Hypergonadotropic hypogonadism (HP:0000815)1.97501230
76Severe global developmental delay (HP:0011344)1.96239197
77Abnormal sex determination (HP:0012244)1.94938136
78Sex reversal (HP:0012245)1.94938136
79Severe visual impairment (HP:0001141)1.93323931
80Thyroiditis (HP:0100646)1.93084236
81Chronic sinusitis (HP:0011109)1.91953009
82Ureteral stenosis (HP:0000071)1.91610134
83Azoospermia (HP:0000027)1.91260108
84Retinal dysplasia (HP:0007973)1.90703170
85Thrombocytosis (HP:0001894)1.90070357
86Recurrent bronchitis (HP:0002837)1.88069315
87Meckel diverticulum (HP:0002245)1.87812308
88Alveolar cell carcinoma (HP:0006519)1.87794270
89Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.87270226
90Attenuation of retinal blood vessels (HP:0007843)1.86271789
91Chronic otitis media (HP:0000389)1.83924536
92Congenital stationary night blindness (HP:0007642)1.82054156
93Aplastic anemia (HP:0001915)1.81996419
94Ragged-red muscle fibers (HP:0003200)1.80676745
95Partial agenesis of the corpus callosum (HP:0001338)1.79035136
96Abnormality of the ileum (HP:0001549)1.77663409
97IgM deficiency (HP:0002850)1.77525662
98Dicarboxylic aciduria (HP:0003215)1.77120632
99Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77120632
100Abnormality of T cells (HP:0002843)1.77101894

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK15.49193674
2MUSK4.23318245
3FES3.41324607
4ZAK3.17531484
5TLK12.93916305
6MARK32.79463184
7SCYL22.63574915
8TAOK32.45450821
9ARAF2.27241516
10GRK62.25712467
11DYRK32.10810779
12PBK1.98345130
13KIT1.79288655
14MAP2K21.78152019
15RPS6KA51.74838003
16IKBKE1.74758526
17STK391.72304131
18ERN11.71630236
19MAP4K21.63199870
20EPHA31.60567850
21IKBKB1.51814533
22TBK11.50844871
23WNK41.50675631
24TXK1.49062918
25MAP2K71.45051648
26MAP3K141.40815518
27KDR1.36822869
28NEK21.28593631
29CDK71.26160516
30RPS6KA41.24371352
31TIE11.22419530
32MYLK1.22193213
33CCNB11.19487092
34TESK21.13892059
35PLK41.10418974
36TESK11.07878042
37MAP3K11.05902703
38CDC71.03927640
39NUAK11.03341079
40MOS1.01177443
41RPS6KA10.91800069
42TEC0.90656008
43ATR0.90156405
44PRKCQ0.90022920
45EPHB10.89837178
46INSRR0.89484337
47RPS6KA20.88099883
48AURKA0.86550582
49RPS6KL10.81159570
50RPS6KC10.81159570
51GRK70.80934023
52RPS6KA60.77407270
53VRK10.75492058
54PIM10.74636321
55NLK0.74345611
56OXSR10.69929987
57PIM20.68761200
58ITK0.68290526
59BRSK20.67970528
60DYRK20.66894629
61IRAK10.64628181
62BTK0.64107444
63MAP3K70.64085662
64MAPK110.61517858
65HCK0.57370483
66BCKDK0.54702844
67NME20.54321023
68VRK20.52712134
69SYK0.51548987
70PKN10.51474540
71MAPK150.50841021
72OBSCN0.49883160
73ATM0.46865899
74LYN0.46383652
75ABL20.46029534
76MAP3K110.43826756
77LCK0.41344771
78ZAP700.41323463
79CDK80.40574588
80FRK0.40149842
81PDK20.39301907
82SGK2230.38871433
83SGK4940.38871433
84ACVR1B0.38642282
85CDK30.38411324
86MAP3K130.38176248
87PIK3CG0.37995766
88TGFBR20.37620180
89MATK0.36450176
90BMPR1B0.35794201
91RAF10.35424321
92RPS6KB10.35369231
93ADRBK20.34755894
94BRAF0.33321299
95CDK40.32276439
96MAPK30.31894451
97HIPK20.31546815
98MAPK90.30018974
99GRK50.29659580
100PLK10.28737042

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004005.21109673
2Olfactory transduction_Homo sapiens_hsa047404.16136498
3DNA replication_Homo sapiens_hsa030303.69029103
4Primary immunodeficiency_Homo sapiens_hsa053403.11155778
5Phenylalanine metabolism_Homo sapiens_hsa003602.47558736
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40841569
7Fanconi anemia pathway_Homo sapiens_hsa034602.35495553
8Mismatch repair_Homo sapiens_hsa034302.30617917
9Homologous recombination_Homo sapiens_hsa034402.22134252
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.18935169
11Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.97885147
12Base excision repair_Homo sapiens_hsa034101.97014174
13Dorso-ventral axis formation_Homo sapiens_hsa043201.75576258
14Non-homologous end-joining_Homo sapiens_hsa034501.75119278
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.73755126
16RNA polymerase_Homo sapiens_hsa030201.60840467
17One carbon pool by folate_Homo sapiens_hsa006701.58996428
18Phototransduction_Homo sapiens_hsa047441.53831376
19Pyrimidine metabolism_Homo sapiens_hsa002401.49629282
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.49600295
21Nitrogen metabolism_Homo sapiens_hsa009101.43177020
22Antigen processing and presentation_Homo sapiens_hsa046121.36206318
23Systemic lupus erythematosus_Homo sapiens_hsa053221.35868242
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33614649
25Purine metabolism_Homo sapiens_hsa002301.28554406
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.28420837
27Tyrosine metabolism_Homo sapiens_hsa003501.26156734
28Basal transcription factors_Homo sapiens_hsa030221.24727724
29Graft-versus-host disease_Homo sapiens_hsa053321.23093931
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22730986
31Fatty acid elongation_Homo sapiens_hsa000621.21746764
32Circadian rhythm_Homo sapiens_hsa047101.13962558
33Asthma_Homo sapiens_hsa053101.10561193
34Oocyte meiosis_Homo sapiens_hsa041141.05165040
35Ribosome_Homo sapiens_hsa030101.04087400
36Nucleotide excision repair_Homo sapiens_hsa034200.97181909
37Alcoholism_Homo sapiens_hsa050340.95425533
38Allograft rejection_Homo sapiens_hsa053300.93216746
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92672780
40Cysteine and methionine metabolism_Homo sapiens_hsa002700.91451677
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90525671
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89912625
43Glutathione metabolism_Homo sapiens_hsa004800.89400480
44Renin secretion_Homo sapiens_hsa049240.89166763
45Herpes simplex infection_Homo sapiens_hsa051680.88376603
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86812581
47Gap junction_Homo sapiens_hsa045400.86136386
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85547494
49Butanoate metabolism_Homo sapiens_hsa006500.83779411
50Tryptophan metabolism_Homo sapiens_hsa003800.83538046
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81963377
52N-Glycan biosynthesis_Homo sapiens_hsa005100.81017602
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80471237
54Type I diabetes mellitus_Homo sapiens_hsa049400.78220466
55Sulfur relay system_Homo sapiens_hsa041220.77870594
56Autoimmune thyroid disease_Homo sapiens_hsa053200.76530527
57Proteasome_Homo sapiens_hsa030500.75334711
58Chemical carcinogenesis_Homo sapiens_hsa052040.74359289
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.73909004
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72868110
61Apoptosis_Homo sapiens_hsa042100.72632896
62Arachidonic acid metabolism_Homo sapiens_hsa005900.72324977
63RNA transport_Homo sapiens_hsa030130.72163855
64Taste transduction_Homo sapiens_hsa047420.69739801
65Leishmaniasis_Homo sapiens_hsa051400.66878941
66Selenocompound metabolism_Homo sapiens_hsa004500.63247212
67Hematopoietic cell lineage_Homo sapiens_hsa046400.62829284
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62797409
69Phagosome_Homo sapiens_hsa041450.62417879
70ABC transporters_Homo sapiens_hsa020100.62258009
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62004182
72Glycerolipid metabolism_Homo sapiens_hsa005610.61187939
73RNA degradation_Homo sapiens_hsa030180.61119822
74mRNA surveillance pathway_Homo sapiens_hsa030150.59873845
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59226421
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59097311
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56792122
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56155364
79Huntingtons disease_Homo sapiens_hsa050160.56090943
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53947197
81T cell receptor signaling pathway_Homo sapiens_hsa046600.50363250
82Hedgehog signaling pathway_Homo sapiens_hsa043400.50196496
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49405115
84Salivary secretion_Homo sapiens_hsa049700.49163109
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48142081
86Viral carcinogenesis_Homo sapiens_hsa052030.46370975
87Parkinsons disease_Homo sapiens_hsa050120.46355883
88Spliceosome_Homo sapiens_hsa030400.41708526
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41101827
90Metabolic pathways_Homo sapiens_hsa011000.39940317
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39304314
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37088021
93Malaria_Homo sapiens_hsa051440.36085878
94Platelet activation_Homo sapiens_hsa046110.33601210
95Peroxisome_Homo sapiens_hsa041460.33115439
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.32038598
97Arginine biosynthesis_Homo sapiens_hsa002200.31932655
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31693093
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30432104
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30271521

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