OR1X1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of interleukin-1 production (GO:0032692)9.41527629
2positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)9.00590632
3positive regulation of sodium ion transmembrane transport (GO:1902307)8.93061966
4negative regulation of peptidyl-serine phosphorylation (GO:0033137)7.62334086
5regulation of response to food (GO:0032095)7.61113114
6response to food (GO:0032094)7.55229873
7regulation of interleukin-6 biosynthetic process (GO:0045408)6.83859248
8hindbrain development (GO:0030902)6.72596170
9regulation of tumor necrosis factor biosynthetic process (GO:0042534)6.61029853
10regulation of appetite (GO:0032098)6.45819430
11one-carbon compound transport (GO:0019755)6.33524574
12positive thymic T cell selection (GO:0045059)5.95514665
13positive regulation of gluconeogenesis (GO:0045722)5.92721671
14regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)5.78939113
15striated muscle atrophy (GO:0014891)5.77816016
16sperm capacitation (GO:0048240)5.72068515
17regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)5.61654040
18decidualization (GO:0046697)5.41841568
19protein kinase B signaling (GO:0043491)5.24988892
20regulation of mitochondrial membrane permeability (GO:0046902)5.09617646
21protein import into peroxisome matrix (GO:0016558)5.09266738
22auditory receptor cell stereocilium organization (GO:0060088)4.94333367
23regulation of membrane permeability (GO:0090559)4.91837369
24muscle atrophy (GO:0014889)4.91451182
25adaptation of signaling pathway (GO:0023058)4.90423204
26skeletal muscle adaptation (GO:0043501)4.84693815
27positive regulation of response to extracellular stimulus (GO:0032106)4.59271843
28positive regulation of response to nutrient levels (GO:0032109)4.59271843
29regulation of somitogenesis (GO:0014807)4.51574518
30positive T cell selection (GO:0043368)4.38789959
31positive regulation of fatty acid metabolic process (GO:0045923)4.36827305
32negative regulation of ERK1 and ERK2 cascade (GO:0070373)4.33574152
33spinal cord development (GO:0021510)4.27202912
34pericardium development (GO:0060039)4.24852324
35regulation of sodium ion transmembrane transporter activity (GO:2000649)4.20652495
36multicellular organism reproduction (GO:0032504)4.15163930
37cysteine metabolic process (GO:0006534)4.12698841
38regulation of digestive system process (GO:0044058)4.10099916
39inner ear receptor stereocilium organization (GO:0060122)4.05039494
40regulation of male gonad development (GO:2000018)4.04996912
41cell morphogenesis involved in neuron differentiation (GO:0048667)4.02836214
422-oxoglutarate metabolic process (GO:0006103)4.01850381
43positive regulation of sodium ion transport (GO:0010765)4.01230385
44water-soluble vitamin biosynthetic process (GO:0042364)3.98641117
45urate metabolic process (GO:0046415)3.85921844
46thymic T cell selection (GO:0045061)3.72698222
47negative regulation of interleukin-6 production (GO:0032715)3.71348827
48negative regulation of cytokine biosynthetic process (GO:0042036)3.70875834
49male sex determination (GO:0030238)3.70198954
50cellular response to pH (GO:0071467)3.69845729
51endocrine pancreas development (GO:0031018)3.66728455
52protein targeting to peroxisome (GO:0006625)3.56476429
53establishment of protein localization to peroxisome (GO:0072663)3.56476429
54protein localization to peroxisome (GO:0072662)3.56476429
55artery development (GO:0060840)3.48047175
56regulation of interleukin-1 beta production (GO:0032651)3.47758131
57negative regulation of tumor necrosis factor production (GO:0032720)3.39413388
58mitochondrion degradation (GO:0000422)3.38471924
59peripheral nervous system development (GO:0007422)3.33797039
60negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)3.28904392
61peroxisomal transport (GO:0043574)3.24913012
62negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.24406804
63positive regulation of muscle cell apoptotic process (GO:0010661)3.23351286
64positive regulation of multicellular organism growth (GO:0040018)3.21908282
65UDP-N-acetylglucosamine metabolic process (GO:0006047)3.21257041
66axonemal dynein complex assembly (GO:0070286)3.14206846
67NAD biosynthetic process (GO:0009435)3.07160938
68regulation of interleukin-1 production (GO:0032652)3.06779690
69regulation of sodium ion transmembrane transport (GO:1902305)3.06525240
70G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.95356136
71detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.94340260
72negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.93718721
73negative regulation of myotube differentiation (GO:0010832)2.93570123
74keratan sulfate catabolic process (GO:0042340)2.93076567
75skeletal muscle tissue regeneration (GO:0043403)2.92425119
76indolalkylamine metabolic process (GO:0006586)2.91817987
77sperm motility (GO:0030317)2.90129187
78organelle membrane fusion (GO:0090174)2.88792079
79positive regulation of microtubule polymerization (GO:0031116)2.87705859
80positive regulation of ion transmembrane transporter activity (GO:0032414)2.87598351
81vasculature development (GO:0001944)2.87160027
82mitochondrial membrane organization (GO:0007006)2.82481287
83protein K11-linked deubiquitination (GO:0035871)2.81997288
84ATP hydrolysis coupled proton transport (GO:0015991)2.79719986
85energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.79719986
86response to pheromone (GO:0019236)2.77837092
87nephron epithelium morphogenesis (GO:0072088)2.77108550
88nephron tubule morphogenesis (GO:0072078)2.77108550
89negative regulation of reproductive process (GO:2000242)2.76797117
90lymphangiogenesis (GO:0001946)2.76624068
91macroautophagy (GO:0016236)2.75899299
92regulation of cardiac muscle cell apoptotic process (GO:0010665)2.75099736
93negative regulation of T cell differentiation in thymus (GO:0033085)2.73225505
94left/right axis specification (GO:0070986)2.67613549
95positive regulation of embryonic development (GO:0040019)2.67280937
96growth hormone secretion (GO:0030252)13.3188623
97positive regulation of sodium ion transmembrane transporter activity (GO:2000651)12.5296878
98negative regulation of interleukin-1 beta production (GO:0032691)11.2592635
99adult feeding behavior (GO:0008343)11.0478541
100regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)10.4196372

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.30812707
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.25616645
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.54861063
4ZNF274_21170338_ChIP-Seq_K562_Hela4.52164257
5AR_21572438_ChIP-Seq_LNCaP_Human4.20140815
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.72821462
7DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.47179536
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.04661019
9RBPJ_22232070_ChIP-Seq_NCS_Mouse3.04609829
10VDR_22108803_ChIP-Seq_LS180_Human2.41022990
11VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.36030669
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.19907112
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.13843385
14GBX2_23144817_ChIP-Seq_PC3_Human1.70508571
15DROSHA_22980978_ChIP-Seq_HELA_Human1.70414705
16IRF1_19129219_ChIP-ChIP_H3396_Human1.58825432
17P300_19829295_ChIP-Seq_ESCs_Human1.57869715
18ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.53752274
19CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53184809
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.52870532
21PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52606691
22SMAD3_21741376_ChIP-Seq_HESCs_Human1.50091524
23MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47598561
24CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.47048164
25GATA3_26560356_Chip-Seq_TH2_Human1.46377095
26EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.45298559
27SMAD4_21741376_ChIP-Seq_ESCs_Human1.44213390
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44030854
29CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.41528669
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38580556
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.37862485
32RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.31754020
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31324867
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.27778838
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.26972241
36PHF8_20622854_ChIP-Seq_HELA_Human1.25787321
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23687594
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.21459782
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20687670
40REST_21632747_ChIP-Seq_MESCs_Mouse1.14292014
41SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13185080
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12834965
43P53_21459846_ChIP-Seq_SAOS-2_Human1.12440026
44RAC3_21632823_ChIP-Seq_H3396_Human1.10029931
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09907093
46FLI1_21867929_ChIP-Seq_TH2_Mouse1.07103748
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06968079
48TP53_22573176_ChIP-Seq_HFKS_Human1.04939384
49SMAD3_21741376_ChIP-Seq_ESCs_Human1.04552123
50CTCF_20526341_ChIP-Seq_ESCs_Human1.04437752
51CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03966142
52BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03698232
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02343526
54MYC_19829295_ChIP-Seq_ESCs_Human1.01634788
55TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00933141
56LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.99869728
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99097372
58ZFP57_27257070_Chip-Seq_ESCs_Mouse0.98282815
59FOXH1_21741376_ChIP-Seq_ESCs_Human0.98131198
60SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.98090626
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97513040
62CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97434827
63YY1_22570637_ChIP-Seq_MALME-3M_Human0.96451402
64ER_23166858_ChIP-Seq_MCF-7_Human0.95971954
65P300_27268052_Chip-Seq_Bcells_Human0.94702967
66EZH2_18974828_ChIP-Seq_MESCs_Mouse0.93645231
67RNF2_18974828_ChIP-Seq_MESCs_Mouse0.93645231
68ERG_21242973_ChIP-ChIP_JURKAT_Human0.92754969
69ERA_21632823_ChIP-Seq_H3396_Human0.91719133
70SPI1_20517297_ChIP-Seq_HL60_Human0.91231198
71GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.91020239
72SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.90140674
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89490508
74KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.88890707
75VDR_24787735_ChIP-Seq_THP-1_Human0.88437232
76CRX_20693478_ChIP-Seq_RETINA_Mouse0.88155597
77EST1_17652178_ChIP-ChIP_JURKAT_Human0.87617518
78TAF2_19829295_ChIP-Seq_ESCs_Human0.87469531
79P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.87173343
80BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86738092
81P68_20966046_ChIP-Seq_HELA_Human0.86229159
82LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.85589149
83PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85209484
84PRDM14_20953172_ChIP-Seq_ESCs_Human0.84883744
85CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.83841005
86ELF1_20517297_ChIP-Seq_JURKAT_Human0.83618523
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.82592335
88CEBPB_22108803_ChIP-Seq_LS180_Human0.82585120
89GATA4_25053715_ChIP-Seq_YYC3_Human0.82314830
90OCT4_20526341_ChIP-Seq_ESCs_Human0.81920120
91WDR5_24793694_ChIP-Seq_LNCAP_Human0.80573256
92KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78418944
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78368444
94POU3F2_20337985_ChIP-ChIP_501MEL_Human0.77486822
95RAD21_21589869_ChIP-Seq_MESCs_Mouse0.77094551
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77064716
97RARA_24833708_ChIP-Seq_LIVER_Mouse0.76672334
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.76512657
99OCT1_27270436_Chip-Seq_PROSTATE_Human0.76105113
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.76095673

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003868_abnormal_feces_composition5.72416052
2MP0003303_peritoneal_inflammation5.62107940
3MP0005220_abnormal_exocrine_pancreas4.82941061
4MP0009278_abnormal_bone_marrow4.30391834
5MP0008872_abnormal_physiological_respon4.11582163
6MP0003172_abnormal_lysosome_physiology3.00200348
7MP0003119_abnormal_digestive_system2.98791831
8MP0002653_abnormal_ependyma_morphology2.90055078
9MP0001664_abnormal_digestion2.75332612
10MP0005084_abnormal_gallbladder_morpholo2.66268074
11MP0005076_abnormal_cell_differentiation2.65407399
12MP0005394_taste/olfaction_phenotype2.56516280
13MP0005499_abnormal_olfactory_system2.56516280
14MP0001663_abnormal_digestive_system2.53615964
15MP0001666_abnormal_nutrient_absorption2.49518525
16MP0001984_abnormal_olfaction2.47555311
17MP0003959_abnormal_lean_body2.42506409
18MP0003866_abnormal_defecation2.37747072
19MP0004130_abnormal_muscle_cell2.37704750
20MP0002928_abnormal_bile_duct2.20897258
21MP0009672_abnormal_birth_weight2.20045213
22MP0003638_abnormal_response/metabolism_2.11003780
23MP0005397_hematopoietic_system_phenotyp2.09212458
24MP0001545_abnormal_hematopoietic_system2.09212458
25MP0000538_abnormal_urinary_bladder1.98054865
26MP0000470_abnormal_stomach_morphology1.95807783
27MP0005381_digestive/alimentary_phenotyp1.93767871
28MP0004147_increased_porphyrin_level1.87557732
29MP0001919_abnormal_reproductive_system1.81188156
30MP0002736_abnormal_nociception_after1.74861871
31MP0010030_abnormal_orbit_morphology1.71816219
32MP0001986_abnormal_taste_sensitivity1.65589954
33MP0003195_calcinosis1.63268535
34MP0002160_abnormal_reproductive_system1.59861901
35MP0002876_abnormal_thyroid_physiology1.57656285
36MP0003646_muscle_fatigue1.51718245
37MP0005448_abnormal_energy_balance1.50674188
38MP0010329_abnormal_lipoprotein_level1.50580003
39MP0003283_abnormal_digestive_organ1.46267358
40MP0003806_abnormal_nucleotide_metabolis1.45138407
41MP0002693_abnormal_pancreas_physiology1.44666214
42MP0001502_abnormal_circadian_rhythm1.43330238
43MP0000015_abnormal_ear_pigmentation1.36685607
44MP0005083_abnormal_biliary_tract1.35713139
45MP0001968_abnormal_touch/_nociception1.29653684
46MP0002282_abnormal_trachea_morphology1.25229008
47MP0000427_abnormal_hair_cycle1.21771383
48MP0002234_abnormal_pharynx_morphology1.17844706
49MP0006292_abnormal_olfactory_placode1.16529638
50MP0009840_abnormal_foam_cell1.14021084
51MP0001270_distended_abdomen1.12692426
52MP0000490_abnormal_crypts_of1.11919275
53MP0001944_abnormal_pancreas_morphology1.09004045
54MP0005389_reproductive_system_phenotype1.07505592
55MP0008875_abnormal_xenobiotic_pharmacok1.07355896
56MP0009643_abnormal_urine_homeostasis1.04860386
57MP0008877_abnormal_DNA_methylation0.97958554
58MP0005647_abnormal_sex_gland0.96699581
59MP0009703_decreased_birth_body0.95507465
60MP0002063_abnormal_learning/memory/cond0.95016514
61MP0001501_abnormal_sleep_pattern0.92973343
62MP0003693_abnormal_embryo_hatching0.91335778
63MP0000858_altered_metastatic_potential0.89764811
64MP0003656_abnormal_erythrocyte_physiolo0.85382486
65MP0001486_abnormal_startle_reflex0.85233203
66MP0004133_heterotaxia0.83438853
67MP0009046_muscle_twitch0.83139661
68MP0005452_abnormal_adipose_tissue0.82802658
69MP0002272_abnormal_nervous_system0.80233245
70MP0004142_abnormal_muscle_tone0.80039877
71MP0002067_abnormal_sensory_capabilities0.73589920
72MP0002557_abnormal_social/conspecific_i0.71527052
73MP0002102_abnormal_ear_morphology0.70870023
74MP0005334_abnormal_fat_pad0.69943422
75MP0002269_muscular_atrophy0.67848245
76MP0001293_anophthalmia0.65407998
77MP0004924_abnormal_behavior0.64465387
78MP0005386_behavior/neurological_phenoty0.64465387
79MP0009379_abnormal_foot_pigmentation0.63628436
80MP0004808_abnormal_hematopoietic_stem0.60415553
81MP0010155_abnormal_intestine_physiology0.59654015
82MP0000026_abnormal_inner_ear0.59317419
83MP0000383_abnormal_hair_follicle0.58444362
84MP0001756_abnormal_urination0.58286754
85MP0002572_abnormal_emotion/affect_behav0.58264563
86MP0002095_abnormal_skin_pigmentation0.57149778
87MP0000566_synostosis0.56928276
88MP0006036_abnormal_mitochondrial_physio0.56910532
89MP0005623_abnormal_meninges_morphology0.54719923
90MP0002078_abnormal_glucose_homeostasis0.54309200
91MP0002734_abnormal_mechanical_nocicepti0.52909567
92MP0003787_abnormal_imprinting0.52627062
93MP0008004_abnormal_stomach_pH0.52194916
94MP0000371_diluted_coat_color0.51689678
95MP0000631_abnormal_neuroendocrine_gland0.49832779
96MP0003953_abnormal_hormone_level0.49200741
97MP0005551_abnormal_eye_electrophysiolog0.48955811
98MP0008995_early_reproductive_senescence0.47131229
99MP0001440_abnormal_grooming_behavior0.46277700
100MP0002933_joint_inflammation0.46100920

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)6.94221367
2Global brain atrophy (HP:0002283)6.57623103
3Birth length less than 3rd percentile (HP:0003561)6.23674665
4Rectal prolapse (HP:0002035)5.50518409
5Nasal polyposis (HP:0100582)5.41655703
6Gastrointestinal infarctions (HP:0005244)5.03316485
7Abnormality of the nasal mucosa (HP:0000433)4.81957733
8Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.81839934
9Abnormality of alanine metabolism (HP:0010916)4.81839934
10Hyperalaninemia (HP:0003348)4.81839934
11Neoplasm of head and neck (HP:0012288)4.49178463
12Esophageal neoplasm (HP:0100751)4.49178463
13Cerebellar dysplasia (HP:0007033)4.40247939
14Retinal dysplasia (HP:0007973)4.30726791
15Breast hypoplasia (HP:0003187)4.12285111
16Abnormality of the fingertips (HP:0001211)4.05408062
17Abnormality of nail color (HP:0100643)3.96879757
18Chorioretinal atrophy (HP:0000533)3.94485612
19Gonadal dysgenesis (HP:0000133)3.85931213
20Metaphyseal dysplasia (HP:0100255)3.51827746
21Spastic tetraparesis (HP:0001285)3.44761861
22Disproportionate short-trunk short stature (HP:0003521)3.44700368
23Absent/shortened dynein arms (HP:0200106)3.37891375
24Dynein arm defect of respiratory motile cilia (HP:0012255)3.37891375
25Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.36921493
26Ulnar deviation of the wrist (HP:0003049)3.31207570
27Cervical subluxation (HP:0003308)3.24205938
28Neonatal onset (HP:0003623)3.21804944
29Progressive inability to walk (HP:0002505)3.18225009
30Pendular nystagmus (HP:0012043)3.13968021
31Mesangial abnormality (HP:0001966)3.13765561
32Prominent supraorbital ridges (HP:0000336)3.12202114
33Bronchomalacia (HP:0002780)3.11088614
34Hypoplastic labia majora (HP:0000059)3.10751755
35Pancreatic fibrosis (HP:0100732)3.09716762
36Biliary tract neoplasm (HP:0100574)3.07383695
37Ulnar claw (HP:0001178)3.03750795
38Hypochromic anemia (HP:0001931)3.00871344
39Inability to walk (HP:0002540)2.99600206
40Abnormal ciliary motility (HP:0012262)2.96315446
41Abnormality of the wing of the ilium (HP:0011867)2.85844400
42Abnormality of the labia majora (HP:0012881)2.82816823
43Hyperventilation (HP:0002883)2.78601310
44Tubular atrophy (HP:0000092)2.67869121
45Long nose (HP:0003189)2.66750839
46Patellar aplasia (HP:0006443)2.62743337
47Clumsiness (HP:0002312)2.60258550
48Lissencephaly (HP:0001339)2.59302033
49Abnormal respiratory motile cilium morphology (HP:0005938)2.59137447
50Abnormal respiratory epithelium morphology (HP:0012253)2.59137447
51Abnormal respiratory motile cilium physiology (HP:0012261)2.56864490
52Abnormality of the vertebral endplates (HP:0005106)2.54838390
53Neoplasm of the rectum (HP:0100743)2.50129467
54Brushfield spots (HP:0001088)2.43702992
55Aplasia/Hypoplasia of the patella (HP:0006498)2.40862095
56Hypoplasia of the odontoid process (HP:0003311)2.38865877
57Pachygyria (HP:0001302)2.36345965
58Germ cell neoplasia (HP:0100728)2.32198622
59Partial agenesis of the corpus callosum (HP:0001338)2.30456766
60High pitched voice (HP:0001620)2.30218283
61Testicular neoplasm (HP:0010788)2.29712519
62Rhinitis (HP:0012384)2.27154753
63Abnormal number of erythroid precursors (HP:0012131)2.21840568
64Keratoconus (HP:0000563)2.19599397
65Increased corneal curvature (HP:0100692)2.19599397
66Cone-rod dystrophy (HP:0000548)2.18797466
67Abolished electroretinogram (ERG) (HP:0000550)2.17735486
68Anterior segment dysgenesis (HP:0007700)2.14371283
69Neoplasm of the small intestine (HP:0100833)2.10235167
70Chronic hepatic failure (HP:0100626)2.09948958
71Pancreatic cysts (HP:0001737)2.09160209
72Brittle hair (HP:0002299)2.07719334
73Attenuation of retinal blood vessels (HP:0007843)2.06227198
74Abnormal biliary tract morphology (HP:0012440)2.03621906
75Delayed closure of the anterior fontanelle (HP:0001476)2.02802910
76Abnormality of the vitreous humor (HP:0004327)2.01819068
77Wide anterior fontanel (HP:0000260)2.01355811
78Progressive microcephaly (HP:0000253)2.00047383
79Rib fusion (HP:0000902)1.99053605
80Abnormality of the odontoid process (HP:0003310)1.97030785
81Nephronophthisis (HP:0000090)1.95828062
82Female pseudohermaphroditism (HP:0010458)1.93805171
83Abnormality of lateral ventricle (HP:0030047)1.93100284
84Abnormality of cells of the erythroid lineage (HP:0012130)1.92593725
85Microretrognathia (HP:0000308)1.92341240
86Labial hypoplasia (HP:0000066)1.92298594
87Abnormality of dental color (HP:0011073)1.92187641
88Congenital stationary night blindness (HP:0007642)1.91315056
89Bile duct proliferation (HP:0001408)1.91035365
90Abnormal biliary tract physiology (HP:0012439)1.91035365
91Chronic otitis media (HP:0000389)1.89967831
92Widely spaced teeth (HP:0000687)1.89286221
93Segmental peripheral demyelination/remyelination (HP:0003481)1.89166669
94Gastrointestinal atresia (HP:0002589)1.88633464
95Aplasia/Hypoplasia of the tibia (HP:0005772)1.87575010
96Alkalosis (HP:0001948)1.87116966
97True hermaphroditism (HP:0010459)1.84254675
98Intellectual disability, profound (HP:0002187)1.81622748
99Short tibia (HP:0005736)1.80412450
100Generalized aminoaciduria (HP:0002909)1.78636627

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK82.72044448
2MAP3K112.42367328
3RPS6KA22.28555007
4RPS6KA52.05955953
5INSRR12.9385956
6RPS6KA61.86877949
7STK111.84968459
8BMPR1B1.81719745
9ABL21.59987436
10RPS6KB11.51060685
11RPS6KC11.49742148
12RPS6KL11.49742148
13PIK3CA1.31743540
14TLK11.23109360
15MAPK121.17673901
16PTK61.16320660
17PRKCZ1.10907461
18CAMKK21.07140983
19TGFBR11.03806159
20FRK1.03045603
21MAP3K21.02408689
22NEK91.00697229
23MAP4K11.00047218
24CAMKK10.97447950
25DYRK1B0.97144386
26LIMK10.95287468
27DAPK20.93661687
28GRK10.93246624
29VRK20.93168592
30ACVR1B0.91131236
31WNK40.87614366
32MAP3K70.87269803
33PNCK0.87240808
34GRK70.84667426
35NME10.82539874
36PDGFRB0.82443889
37MAP3K130.81131157
38ADRBK20.80652893
39TAOK30.78478602
40CDK90.78244957
41TNK20.74839342
42PKN10.74623785
43CAMK1G0.74484583
44PTK2B0.70373201
45ITK0.67636363
46AKT20.65153851
47MARK10.64774769
48CAMK1D0.63702715
49OXSR10.63318384
50IRAK40.63138748
51ADRBK10.62095337
52JAK30.59956845
53STK390.58931788
54IKBKB0.58762610
55VRK10.57333725
56MAP4K20.56370422
57NEK60.53283991
58PASK0.47621995
59CHUK0.47093546
60PHKG20.45314075
61PHKG10.45314075
62RPS6KA10.43095379
63TSSK60.42148017
64PRKCA0.41529021
65MAP3K120.38730036
66HCK0.37146421
67MAPK70.37008460
68NEK20.36675902
69PRKG10.35229901
70ABL10.34837230
71ZAP700.34796512
72FYN0.33964974
73DAPK30.33269795
74MAPKAPK50.32438368
75PAK30.32267348
76LCK0.32107022
77MAPK150.31982358
78CAMK2A0.31596372
79CSF1R0.31080973
80PAK60.30322079
81SYK0.29929806
82OBSCN0.28374253
83CDK40.28023798
84CAMK2D0.27825925
85BUB10.27581876
86RPS6KA30.26298571
87AKT10.26269117
88TYRO30.25994569
89PRKAA10.25716388
90BTK0.25676555
91MELK0.25134200
92LYN0.25057021
93PRKACA0.24928852
94PRKCG0.24563113
95PDK10.24243373
96CDK30.23885715
97BLK0.23618334
98PRKDC0.23056741
99TIE10.22823809
100ATM0.22683281

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.51512721
2Butanoate metabolism_Homo sapiens_hsa006505.10793027
3Nitrogen metabolism_Homo sapiens_hsa009103.79987812
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.25521602
5Linoleic acid metabolism_Homo sapiens_hsa005912.66503230
6Ether lipid metabolism_Homo sapiens_hsa005652.53371214
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.51344146
8Selenocompound metabolism_Homo sapiens_hsa004502.47355635
9Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.33588877
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.32411777
11Basal transcription factors_Homo sapiens_hsa030222.18947094
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.13082800
13Homologous recombination_Homo sapiens_hsa034402.08281411
14Caffeine metabolism_Homo sapiens_hsa002321.94500034
15RNA polymerase_Homo sapiens_hsa030201.91431544
16Tryptophan metabolism_Homo sapiens_hsa003801.80789442
17Sulfur relay system_Homo sapiens_hsa041221.78074522
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73315281
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.66723050
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.63010650
21Fanconi anemia pathway_Homo sapiens_hsa034601.61645514
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.58579954
23Longevity regulating pathway - mammal_Homo sapiens_hsa042111.24741034
24Insulin secretion_Homo sapiens_hsa049111.22958801
25Nicotine addiction_Homo sapiens_hsa050331.20405762
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.12747392
27Cocaine addiction_Homo sapiens_hsa050301.12247636
28Nucleotide excision repair_Homo sapiens_hsa034201.06809376
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01134233
30Thyroid hormone synthesis_Homo sapiens_hsa049180.96395209
31Phototransduction_Homo sapiens_hsa047440.95911842
32Histidine metabolism_Homo sapiens_hsa003400.93758087
33Olfactory transduction_Homo sapiens_hsa047400.92864004
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92264777
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91129662
36Arachidonic acid metabolism_Homo sapiens_hsa005900.89111407
37Basal cell carcinoma_Homo sapiens_hsa052170.85409547
38Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84083963
39TNF signaling pathway_Homo sapiens_hsa046680.83832669
40cAMP signaling pathway_Homo sapiens_hsa040240.83503258
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81160094
42Lysosome_Homo sapiens_hsa041420.79838602
43Peroxisome_Homo sapiens_hsa041460.78846928
44Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78140825
45ABC transporters_Homo sapiens_hsa020100.76846667
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.76510300
47Chemical carcinogenesis_Homo sapiens_hsa052040.73875008
48PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72277714
49One carbon pool by folate_Homo sapiens_hsa006700.70833664
50Retinol metabolism_Homo sapiens_hsa008300.67849046
51Taste transduction_Homo sapiens_hsa047420.65949753
52Ribosome_Homo sapiens_hsa030100.61908382
53Amphetamine addiction_Homo sapiens_hsa050310.61694876
54Notch signaling pathway_Homo sapiens_hsa043300.60506247
55Oxidative phosphorylation_Homo sapiens_hsa001900.57672786
56Calcium signaling pathway_Homo sapiens_hsa040200.57199718
57Collecting duct acid secretion_Homo sapiens_hsa049660.55669538
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.55522583
59Ovarian steroidogenesis_Homo sapiens_hsa049130.55171074
60Starch and sucrose metabolism_Homo sapiens_hsa005000.45901070
61mTOR signaling pathway_Homo sapiens_hsa041500.45506529
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45016765
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44847763
64Fat digestion and absorption_Homo sapiens_hsa049750.44323208
65Mineral absorption_Homo sapiens_hsa049780.43174862
66Metabolic pathways_Homo sapiens_hsa011000.42055646
67Staphylococcus aureus infection_Homo sapiens_hsa051500.39633422
68Pyrimidine metabolism_Homo sapiens_hsa002400.39205217
69Glycerolipid metabolism_Homo sapiens_hsa005610.37669426
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35398597
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.33904164
72Huntingtons disease_Homo sapiens_hsa050160.32674873
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30872059
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29996913
75Tyrosine metabolism_Homo sapiens_hsa003500.29323971
76Purine metabolism_Homo sapiens_hsa002300.28452034
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27805027
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27788373
79Sphingolipid metabolism_Homo sapiens_hsa006000.27386919
80Protein export_Homo sapiens_hsa030600.27238322
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27082146
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26262215
83beta-Alanine metabolism_Homo sapiens_hsa004100.25703346
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23853905
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22360222
86Parkinsons disease_Homo sapiens_hsa050120.21320322
87Arginine and proline metabolism_Homo sapiens_hsa003300.21289635
88Estrogen signaling pathway_Homo sapiens_hsa049150.20194202
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18828872
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.17891852
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.15450783
92Mismatch repair_Homo sapiens_hsa034300.12251007
93Serotonergic synapse_Homo sapiens_hsa047260.12121252
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.11540012
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.07881341
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.07313050
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.05806504
98Type II diabetes mellitus_Homo sapiens_hsa049300.05614956
99Renin-angiotensin system_Homo sapiens_hsa046140.05569176
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.05078299

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