OR2A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heparin biosynthetic process (GO:0030210)8.66021278
2heparin metabolic process (GO:0030202)8.66021278
3cellular response to interleukin-15 (GO:0071350)6.60684700
4heparan sulfate proteoglycan biosynthetic process (GO:0015012)5.93336652
5tongue development (GO:0043586)5.67198296
6negative regulation of translation involved in gene silencing by miRNA (GO:0035278)5.65746676
7negative regulation of translation, ncRNA-mediated (GO:0040033)5.65746676
8regulation of translation, ncRNA-mediated (GO:0045974)5.65746676
9response to interleukin-15 (GO:0070672)5.49947915
10pre-miRNA processing (GO:0031054)4.97277456
11cell wall macromolecule catabolic process (GO:0016998)4.68394164
12translesion synthesis (GO:0019985)4.53448834
13poly(A)+ mRNA export from nucleus (GO:0016973)4.40817579
14cell wall macromolecule metabolic process (GO:0044036)4.38548697
15negative regulation of B cell proliferation (GO:0030889)4.36253247
16negative regulation of alpha-beta T cell activation (GO:0046636)4.27020731
17interferon-gamma secretion (GO:0072643)4.22775969
18positive regulation of protein kinase C signaling (GO:0090037)4.18245203
19multicellular organism reproduction (GO:0032504)4.10195151
20replication fork processing (GO:0031297)3.99759598
21radial glial cell differentiation (GO:0060019)3.96836119
22regulation of protein polyubiquitination (GO:1902914)3.83429419
23histone mRNA catabolic process (GO:0071044)3.77575931
24N-terminal protein amino acid acetylation (GO:0006474)3.76942515
25DNA strand renaturation (GO:0000733)3.74659165
26negative regulation of synaptic transmission, GABAergic (GO:0032229)3.71077177
27regulation of alpha-beta T cell proliferation (GO:0046640)3.66001975
28lateral sprouting from an epithelium (GO:0060601)3.65575953
29mRNA cleavage (GO:0006379)3.60157566
30DNA double-strand break processing (GO:0000729)3.56103397
31heparan sulfate proteoglycan metabolic process (GO:0030201)3.49422371
32myelin assembly (GO:0032288)3.45027715
33histone H3-K36 demethylation (GO:0070544)3.42812626
34ribosome assembly (GO:0042255)3.39716530
35glomerular basement membrane development (GO:0032836)3.37073514
36regulation of phospholipase A2 activity (GO:0032429)3.34336631
37coenzyme catabolic process (GO:0009109)3.31354926
38proteoglycan biosynthetic process (GO:0030166)3.26896910
39negative regulation of DNA repair (GO:0045738)3.26850874
40kidney morphogenesis (GO:0060993)3.23193898
41serine family amino acid catabolic process (GO:0009071)3.22503255
42negative regulation of defense response to virus (GO:0050687)3.21238980
43* detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.16238753
44carnitine metabolic process (GO:0009437)3.15986286
45negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.15505960
46retinal cone cell development (GO:0046549)3.13957233
47regulation of autophagic vacuole assembly (GO:2000785)3.12209788
48negative thymic T cell selection (GO:0045060)3.10188721
49positive regulation of B cell differentiation (GO:0045579)3.04561394
50reciprocal meiotic recombination (GO:0007131)3.02637464
51reciprocal DNA recombination (GO:0035825)3.02637464
52wound healing, spreading of epidermal cells (GO:0035313)3.02399893
53B cell proliferation (GO:0042100)3.01990563
54fucose catabolic process (GO:0019317)2.99654296
55L-fucose metabolic process (GO:0042354)2.99654296
56L-fucose catabolic process (GO:0042355)2.99654296
57negative T cell selection (GO:0043383)2.94742528
58neural tube formation (GO:0001841)2.94300695
59artery development (GO:0060840)2.91124783
60regulation of fibroblast apoptotic process (GO:2000269)2.91018680
61regulation of gene silencing by RNA (GO:0060966)2.90438235
62regulation of posttranscriptional gene silencing (GO:0060147)2.90438235
63regulation of gene silencing by miRNA (GO:0060964)2.90438235
64positive regulation of catenin import into nucleus (GO:0035413)2.87132618
65autophagic vacuole fusion (GO:0000046)2.85145578
66regulation of B cell receptor signaling pathway (GO:0050855)2.81996572
67protein K63-linked deubiquitination (GO:0070536)2.81468348
68regulation of phosphoprotein phosphatase activity (GO:0043666)2.80839301
69carnitine transmembrane transport (GO:1902603)2.78481751
70lens development in camera-type eye (GO:0002088)2.78438062
71organ growth (GO:0035265)2.77842629
72regulation of hippo signaling (GO:0035330)2.77269140
73regulation of vacuole organization (GO:0044088)2.76439570
74activation of protein kinase B activity (GO:0032148)2.75832273
75presynaptic membrane assembly (GO:0097105)2.75575136
76positive regulation of neurological system process (GO:0031646)2.71492813
77negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.69339836
78carnitine transport (GO:0015879)2.69132532
79amino-acid betaine transport (GO:0015838)2.69132532
80regulation of receptor binding (GO:1900120)2.67577172
81double-strand break repair via homologous recombination (GO:0000724)2.66874244
82rhodopsin mediated signaling pathway (GO:0016056)2.65147090
83recombinational repair (GO:0000725)2.64214490
84atrial cardiac muscle cell action potential (GO:0086014)2.62993157
85negative regulation of translational initiation (GO:0045947)2.61924193
86cellular ketone body metabolic process (GO:0046950)2.60260636
87otic vesicle formation (GO:0030916)2.60026533
88postreplication repair (GO:0006301)2.57204052
89regulation of B cell proliferation (GO:0030888)2.54144533
90thymic T cell selection (GO:0045061)2.52166564
91cellular response to zinc ion (GO:0071294)2.50603463
92smoothened signaling pathway (GO:0007224)2.49761782
93mast cell degranulation (GO:0043303)2.49713791
94mast cell activation involved in immune response (GO:0002279)2.49713791
95cytoplasmic mRNA processing body assembly (GO:0033962)2.49473638
96positive regulation of glycogen metabolic process (GO:0070875)2.48805044
97N-acetylglucosamine metabolic process (GO:0006044)2.48714660
98positive regulation of protein import into nucleus, translocation (GO:0033160)2.48368533
99transcription from mitochondrial promoter (GO:0006390)2.47179611
100regulation of establishment of cell polarity (GO:2000114)2.46495471

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.88005735
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.83600077
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.65274749
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.64325093
5IGF1R_20145208_ChIP-Seq_DFB_Human4.14118515
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.73273291
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.38600996
8GBX2_23144817_ChIP-Seq_PC3_Human3.24379911
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.61727980
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.41110563
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34569375
12VDR_22108803_ChIP-Seq_LS180_Human2.33637470
13AR_21572438_ChIP-Seq_LNCaP_Human2.31419371
14P300_19829295_ChIP-Seq_ESCs_Human2.16362551
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14563476
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.13652449
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.95946023
18ER_23166858_ChIP-Seq_MCF-7_Human1.91196320
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90287292
20TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87865633
21POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.87865633
22TAF15_26573619_Chip-Seq_HEK293_Human1.83070645
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82491983
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78081412
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76900416
26ZNF274_21170338_ChIP-Seq_K562_Hela1.75353229
27ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.72663086
28EWS_26573619_Chip-Seq_HEK293_Human1.69145975
29WDR5_24793694_ChIP-Seq_LNCAP_Human1.60621169
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59995013
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56943609
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53378117
33FUS_26573619_Chip-Seq_HEK293_Human1.49970679
34SMAD4_21799915_ChIP-Seq_A2780_Human1.48849549
35ARNT_22903824_ChIP-Seq_MCF-7_Human1.46863197
36AHR_22903824_ChIP-Seq_MCF-7_Human1.46150551
37CBP_20019798_ChIP-Seq_JUKART_Human1.45678365
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45678365
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45603585
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41317539
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36838782
42RXR_22108803_ChIP-Seq_LS180_Human1.35275581
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34790428
44STAT3_23295773_ChIP-Seq_U87_Human1.33644297
45CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.32949927
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30693525
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30348616
48TCF4_23295773_ChIP-Seq_U87_Human1.29025811
49BCAT_22108803_ChIP-Seq_LS180_Human1.28542421
50RUNX2_22187159_ChIP-Seq_PCA_Human1.26205624
51KDM2B_26808549_Chip-Seq_REH_Human1.23144139
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19486787
53PRDM14_20953172_ChIP-Seq_ESCs_Human1.19055067
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.18669084
55EGR1_19032775_ChIP-ChIP_M12_Human1.17877338
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.17273187
57AR_25329375_ChIP-Seq_VCAP_Human1.17113460
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15552130
59RUNX_20019798_ChIP-Seq_JUKART_Human1.15078950
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.14707544
61TCF4_22108803_ChIP-Seq_LS180_Human1.12439847
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12392462
63CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12322415
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11286682
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08707838
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.08700671
67SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08602887
68ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07748672
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05689525
70FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02871090
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02822969
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01513929
73TBL1_22424771_ChIP-Seq_293T_Human1.00639701
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00245484
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99952425
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99727792
77GATA3_26560356_Chip-Seq_TH2_Human0.99053549
78SALL1_21062744_ChIP-ChIP_HESCs_Human0.98657020
79FOXH1_21741376_ChIP-Seq_EPCs_Human0.98396715
80TP53_16413492_ChIP-PET_HCT116_Human0.98358794
81CDX2_22108803_ChIP-Seq_LS180_Human0.98128088
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97216216
83FOXA1_25329375_ChIP-Seq_VCAP_Human0.97216216
84VDR_24787735_ChIP-Seq_THP-1_Human0.96341006
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94951292
86GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93484040
87HOXB7_26014856_ChIP-Seq_BT474_Human0.92270186
88CIITA_25753668_ChIP-Seq_RAJI_Human0.90837995
89AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90153463
90SOX2_21211035_ChIP-Seq_LN229_Gbm0.88585402
91MYC_18940864_ChIP-ChIP_HL60_Human0.88562785
92NANOG_19829295_ChIP-Seq_ESCs_Human0.88260501
93SOX2_19829295_ChIP-Seq_ESCs_Human0.88260501
94ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88114886
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86212387
96DROSHA_22980978_ChIP-Seq_HELA_Human0.86162607
97FOXM1_26456572_ChIP-Seq_MCF-7_Human0.85901107
98VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85738356
99SMAD3_21741376_ChIP-Seq_EPCs_Human0.84097802
100P53_22387025_ChIP-Seq_ESCs_Mouse0.84036885

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.08295242
2MP0002138_abnormal_hepatobiliary_system4.99060416
3MP0008057_abnormal_DNA_replication4.46029867
4MP0009697_abnormal_copulation3.97458642
5MP0008877_abnormal_DNA_methylation3.92972859
6MP0008004_abnormal_stomach_pH3.81048290
7MP0005671_abnormal_response_to3.16083055
8MP0000569_abnormal_digit_pigmentation2.88307623
9MP0004272_abnormal_basement_membrane2.53657942
10MP0002009_preneoplasia2.53405928
11MP0003787_abnormal_imprinting2.12758749
12MP0002139_abnormal_hepatobiliary_system2.08375922
13MP0003315_abnormal_perineum_morphology1.97656624
14MP0004264_abnormal_extraembryonic_tissu1.96841019
15MP0003868_abnormal_feces_composition1.93937818
16MP0009046_muscle_twitch1.92676465
17MP0001800_abnormal_humoral_immune1.89625913
18MP0006072_abnormal_retinal_apoptosis1.84685264
19MP0001835_abnormal_antigen_presentation1.83246808
20MP0001661_extended_life_span1.79115259
21MP0003763_abnormal_thymus_physiology1.73677731
22MP0004381_abnormal_hair_follicle1.72685681
23MP0004084_abnormal_cardiac_muscle1.62704522
24MP0004147_increased_porphyrin_level1.59798593
25MP0002132_abnormal_respiratory_system1.55574606
26MP0005253_abnormal_eye_physiology1.52441258
27MP0000566_synostosis1.50869487
28MP0003806_abnormal_nucleotide_metabolis1.50241423
29MP0003385_abnormal_body_wall1.50081115
30MP0003121_genomic_imprinting1.49272162
31MP0002166_altered_tumor_susceptibility1.44839578
32MP0002102_abnormal_ear_morphology1.44778149
33MP0002332_abnormal_exercise_endurance1.38631269
34MP0000013_abnormal_adipose_tissue1.34363112
35MP0005248_abnormal_Harderian_gland1.31811578
36MP0001764_abnormal_homeostasis1.27093635
37MP0003646_muscle_fatigue1.27079862
38MP0003724_increased_susceptibility_to1.24656527
39MP0009764_decreased_sensitivity_to1.17151725
40MP0005551_abnormal_eye_electrophysiolog1.13445422
41MP0001929_abnormal_gametogenesis1.04644775
42MP0006138_congestive_heart_failure1.04091816
43MP0005408_hypopigmentation1.03731488
44MP0004883_abnormal_blood_vessel1.02376438
45MP0003183_abnormal_peptide_metabolism1.02278971
46MP0003011_delayed_dark_adaptation1.01459979
47MP0002108_abnormal_muscle_morphology1.01170288
48MP0001849_ear_inflammation1.00516176
49MP0000230_abnormal_systemic_arterial1.00006367
50MP0002420_abnormal_adaptive_immunity0.97406674
51MP0001664_abnormal_digestion0.96563473
52MP0005451_abnormal_body_composition0.96040314
53MP0002452_abnormal_antigen_presenting0.95248914
54MP0000383_abnormal_hair_follicle0.93709391
55MP0009780_abnormal_chondrocyte_physiolo0.93381518
56MP0010368_abnormal_lymphatic_system0.92875163
57MP0005365_abnormal_bile_salt0.92583764
58MP0001485_abnormal_pinna_reflex0.91615570
59MP0002723_abnormal_immune_serum0.91402797
60MP0001501_abnormal_sleep_pattern0.89961853
61MP0003698_abnormal_male_reproductive0.89641494
62MP0002398_abnormal_bone_marrow0.89594276
63MP0005410_abnormal_fertilization0.88686743
64MP0001819_abnormal_immune_cell0.87995152
65MP0005266_abnormal_metabolism0.87500272
66MP0004484_altered_response_of0.87453915
67MP0002160_abnormal_reproductive_system0.87192928
68MP0005376_homeostasis/metabolism_phenot0.85702410
69MP0003938_abnormal_ear_development0.84497650
70MP0005391_vision/eye_phenotype0.83748570
71MP0010386_abnormal_urinary_bladder0.81349773
72MP0005000_abnormal_immune_tolerance0.81050542
73MP0001756_abnormal_urination0.80949795
74MP0005310_abnormal_salivary_gland0.80832685
75MP0005394_taste/olfaction_phenotype0.77579551
76MP0005499_abnormal_olfactory_system0.77579551
77MP0000703_abnormal_thymus_morphology0.76503060
78MP0003936_abnormal_reproductive_system0.76378606
79MP0002928_abnormal_bile_duct0.76216930
80MP0002168_other_aberrant_phenotype0.76112256
81MP0004036_abnormal_muscle_relaxation0.74963007
82MP0000427_abnormal_hair_cycle0.74448842
83MP0002006_tumorigenesis0.73382280
84MP0000465_gastrointestinal_hemorrhage0.72901725
85MP0010094_abnormal_chromosome_stability0.72489502
86MP0000716_abnormal_immune_system0.72254513
87MP0005448_abnormal_energy_balance0.71372124
88MP0005167_abnormal_blood-brain_barrier0.66812331
89MP0003937_abnormal_limbs/digits/tail_de0.66055510
90MP0000428_abnormal_craniofacial_morphol0.64790377
91MP0002127_abnormal_cardiovascular_syste0.64286772
92MP0003890_abnormal_embryonic-extraembry0.63968091
93MP0005084_abnormal_gallbladder_morpholo0.62017077
94MP0000749_muscle_degeneration0.59045536
95MP0002115_abnormal_skeleton_extremities0.57459834
96MP0006036_abnormal_mitochondrial_physio0.57079228
97MP0002722_abnormal_immune_system0.57044111
98MP0005395_other_phenotype0.56762634
99MP0001145_abnormal_male_reproductive0.56385360
100MP0000470_abnormal_stomach_morphology0.55296789

Predicted human phenotypes

RankGene SetZ-score
1Hypoplastic nipples (HP:0002557)5.17451328
2Sensory axonal neuropathy (HP:0003390)4.85335767
3Clumsiness (HP:0002312)4.19507167
4Bifid scrotum (HP:0000048)3.70931707
5Hypoglycemic seizures (HP:0002173)3.63794358
6Wide intermamillary distance (HP:0006610)3.59295095
7Abnormality of the columella (HP:0009929)3.57252774
8Agammaglobulinemia (HP:0004432)3.43620574
9Chronic sinusitis (HP:0011109)3.21992305
10Abolished electroretinogram (ERG) (HP:0000550)3.21754448
11Renal hypoplasia (HP:0000089)3.18897917
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.17535017
13Panhypogammaglobulinemia (HP:0003139)3.13155920
14Chronic hepatic failure (HP:0100626)3.04781159
15Bile duct proliferation (HP:0001408)2.94174839
16Abnormal biliary tract physiology (HP:0012439)2.94174839
17Capillary hemangiomas (HP:0005306)2.84192255
18Abnormal rod and cone electroretinograms (HP:0008323)2.84111453
19Attenuation of retinal blood vessels (HP:0007843)2.83442368
20Reduced antithrombin III activity (HP:0001976)2.82946012
21True hermaphroditism (HP:0010459)2.80169139
22Eosinophilia (HP:0001880)2.76295098
23Vitreoretinal degeneration (HP:0000655)2.73146283
24Hyporeflexia of lower limbs (HP:0002600)2.68021400
25Zonular cataract (HP:0010920)2.59195040
26Resting tremor (HP:0002322)2.58838484
27T lymphocytopenia (HP:0005403)2.54588923
28Long foot (HP:0001833)2.48262760
29High anterior hairline (HP:0009890)2.45972123
30Median cleft lip (HP:0000161)2.43007027
31Protruding tongue (HP:0010808)2.41903616
32Mesomelia (HP:0003027)2.39934464
33Congenital sensorineural hearing impairment (HP:0008527)2.38576134
34Nonprogressive disorder (HP:0003680)2.37404867
35Symptomatic seizures (HP:0011145)2.37256142
36Recurrent viral infections (HP:0004429)2.36965062
37Abnormal ciliary motility (HP:0012262)2.34587154
38Aplasia/Hypoplasia of the nipples (HP:0006709)2.29192158
39Pancreatic islet-cell hyperplasia (HP:0004510)2.28447289
40Aplasia/Hypoplasia of the tongue (HP:0010295)2.23982264
41Thickened helices (HP:0000391)2.22936222
42Facial hemangioma (HP:0000329)2.20585350
43Thyroiditis (HP:0100646)2.19878899
44Enlarged penis (HP:0000040)2.19827570
45Bony spicule pigmentary retinopathy (HP:0007737)2.18996188
46Pigmentary retinal degeneration (HP:0001146)2.18055975
47Aortic aneurysm (HP:0004942)2.17225790
48Abnormality of eosinophils (HP:0001879)2.15597648
49Abnormality of T cell number (HP:0011839)2.15310920
50Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.13573631
51Pancytopenia (HP:0001876)2.12862887
52Hypoplasia of the thymus (HP:0000778)2.11765724
53Pancreatic fibrosis (HP:0100732)2.11429504
54Inability to walk (HP:0002540)2.10877972
55Thyroid-stimulating hormone excess (HP:0002925)2.07201737
56Recurrent fungal infections (HP:0002841)2.05498900
57Progressive inability to walk (HP:0002505)2.05249620
58Clubbing of toes (HP:0100760)2.04935940
59Ectopic kidney (HP:0000086)2.03924673
60Dynein arm defect of respiratory motile cilia (HP:0012255)2.03774849
61Absent/shortened dynein arms (HP:0200106)2.03774849
62Colitis (HP:0002583)2.00338365
63Preaxial foot polydactyly (HP:0001841)1.99182069
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97996756
65Short 4th metacarpal (HP:0010044)1.97563068
66Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.97563068
67Pancreatic cysts (HP:0001737)1.95225625
68Abnormality of the incisor (HP:0000676)1.95029690
69Congenital stationary night blindness (HP:0007642)1.94959591
70Focal motor seizures (HP:0011153)1.93607254
71B lymphocytopenia (HP:0010976)1.92478446
72Visual hallucinations (HP:0002367)1.91472814
73Papillary thyroid carcinoma (HP:0002895)1.90252447
74Postaxial foot polydactyly (HP:0001830)1.90108955
75Broad-based gait (HP:0002136)1.90030599
76Male pseudohermaphroditism (HP:0000037)1.88978789
77Abnormal delayed hypersensitivity skin test (HP:0002963)1.87661351
78Broad alveolar ridges (HP:0000187)1.87159794
79Abnormal hair whorl (HP:0010721)1.87131286
80Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86820956
81Accelerated skeletal maturation (HP:0005616)1.86241429
82IgA deficiency (HP:0002720)1.84181876
83Azoospermia (HP:0000027)1.84016135
84Hypoproteinemia (HP:0003075)1.83735501
85Inflammation of the large intestine (HP:0002037)1.83644260
86Optic nerve hypoplasia (HP:0000609)1.82898083
87Ketosis (HP:0001946)1.82343869
88Increased neuronal autofluorescent lipopigment (HP:0002074)1.82125691
89Short chin (HP:0000331)1.78664632
90Abnormality of DNA repair (HP:0003254)1.78502731
91Hyperinsulinemic hypoglycemia (HP:0000825)1.77969321
92Pili torti (HP:0003777)1.76442733
93IgG deficiency (HP:0004315)1.74185873
94Pustule (HP:0200039)1.72363173
95Aplasia/Hypoplasia of the macula (HP:0008059)1.71463147
96Round face (HP:0000311)1.71413252
97Dyschromatopsia (HP:0007641)1.70322273
98Hypoplasia of the fovea (HP:0007750)1.70167241
99Aplasia/Hypoplasia of the fovea (HP:0008060)1.70167241
100Abnormal respiratory epithelium morphology (HP:0012253)1.69149764

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.20589914
2PINK14.18906760
3LATS13.79825929
4BMPR1B3.16900767
5JAK33.16257675
6CDK193.08351459
7MAP3K103.06047980
8FRK2.99765185
9MARK32.72607556
10IRAK22.47614262
11ZAK2.29299480
12TGFBR12.04878347
13NEK22.04404735
14NLK1.97950548
15GRK11.96197448
16CAMK1D1.91132484
17NUAK11.79420001
18FGFR21.77594598
19IRAK11.73397355
20PIK3CG1.69451280
21SIK21.67152151
22CDK121.61772075
23STK38L1.53295768
24ADRBK21.50744247
25TRPM71.44474573
26OBSCN1.43141694
27TIE11.42737159
28CAMK1G1.42260097
29MAP4K11.37540796
30TLK11.34861706
31MYLK1.29763073
32CDK31.28520393
33SGK21.22651732
34FGR1.22064192
35STK31.16168206
36SGK2231.07506523
37SGK4941.07506523
38CDK91.04418056
39BTK0.99649560
40SYK0.99426892
41CDK80.97843653
42MAP4K20.92674006
43TAOK10.88675638
44MAP3K130.79410807
45CAMKK20.78648789
46TGFBR20.75450281
47PRKCQ0.74384077
48MELK0.73927341
49MAP2K70.72826979
50OXSR10.71186417
51MAP3K30.70898545
52RIPK40.66471021
53STK380.65592099
54ACVR1B0.64647162
55MAP2K30.62503656
56PRKD20.60309239
57BLK0.59978563
58RPS6KB10.59613800
59KIT0.56788021
60CAMK10.55150740
61CAMK40.53637684
62RPS6KA40.53557528
63MAPK120.52764846
64MAPK110.49730391
65PRKAA10.49323074
66SGK30.45241415
67ROCK10.44736687
68STK390.42602271
69FGFR30.42305973
70LCK0.41485930
71TNIK0.41360636
72ATM0.39393814
73CSNK1G10.37182039
74PRKCE0.36432593
75MAPK150.35259274
76EGFR0.33360856
77PDGFRB0.32908794
78RPS6KA50.32898809
79PRKG20.32123998
80ITK0.31131006
81CSNK1A1L0.29785984
82FES0.29251298
83DYRK20.27726343
84PRKCH0.27206079
85WNK30.26623341
86CSNK1D0.25663748
87PTK2B0.25632014
88HCK0.24694004
89ICK0.24408630
90TNK20.24218138
91MKNK20.22920197
92CDK40.22089282
93CSNK1A10.21010609
94PRKCB0.20324207
95MAP3K50.20244001
96MAP3K10.20151995
97CHEK20.19651218
98MAPK130.18591651
99SGK10.18006819
100LYN0.17979582

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005343.28046594
2Phototransduction_Homo sapiens_hsa047443.25209270
3Asthma_Homo sapiens_hsa053103.21859736
4* Olfactory transduction_Homo sapiens_hsa047402.94606487
5Allograft rejection_Homo sapiens_hsa053302.72156249
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.68558544
7Autoimmune thyroid disease_Homo sapiens_hsa053202.65702465
8Fanconi anemia pathway_Homo sapiens_hsa034602.64338110
9Primary immunodeficiency_Homo sapiens_hsa053402.48041152
10Graft-versus-host disease_Homo sapiens_hsa053322.42624423
11Homologous recombination_Homo sapiens_hsa034402.11596472
12Nitrogen metabolism_Homo sapiens_hsa009101.77388066
13Type I diabetes mellitus_Homo sapiens_hsa049401.76803264
14Selenocompound metabolism_Homo sapiens_hsa004501.70540756
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.64275109
16Butanoate metabolism_Homo sapiens_hsa006501.61647864
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.59585373
18Leishmaniasis_Homo sapiens_hsa051401.57347978
19Staphylococcus aureus infection_Homo sapiens_hsa051501.52191345
20Systemic lupus erythematosus_Homo sapiens_hsa053221.44244949
21Chemical carcinogenesis_Homo sapiens_hsa052041.32274974
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25419269
23Antigen processing and presentation_Homo sapiens_hsa046121.18981909
24Basal transcription factors_Homo sapiens_hsa030221.17406299
25Viral myocarditis_Homo sapiens_hsa054161.13767747
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13685373
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10580569
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.07233124
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05539679
30Herpes simplex infection_Homo sapiens_hsa051681.02090642
31Hematopoietic cell lineage_Homo sapiens_hsa046401.01996984
32Lysine degradation_Homo sapiens_hsa003101.01769314
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01100930
34Steroid hormone biosynthesis_Homo sapiens_hsa001400.99766414
35Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98947985
36Toxoplasmosis_Homo sapiens_hsa051450.95463928
37Vascular smooth muscle contraction_Homo sapiens_hsa042700.94317222
38Hedgehog signaling pathway_Homo sapiens_hsa043400.92601851
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.91894261
40SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91312735
41RNA polymerase_Homo sapiens_hsa030200.91269732
42B cell receptor signaling pathway_Homo sapiens_hsa046620.85248636
43Linoleic acid metabolism_Homo sapiens_hsa005910.80584984
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78444121
45Retinol metabolism_Homo sapiens_hsa008300.75973972
46Tuberculosis_Homo sapiens_hsa051520.74834702
47Arachidonic acid metabolism_Homo sapiens_hsa005900.74673118
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73322927
49Influenza A_Homo sapiens_hsa051640.72928826
50Circadian rhythm_Homo sapiens_hsa047100.72378022
51ABC transporters_Homo sapiens_hsa020100.71786885
52Oxytocin signaling pathway_Homo sapiens_hsa049210.70361806
53FoxO signaling pathway_Homo sapiens_hsa040680.67442474
54Taste transduction_Homo sapiens_hsa047420.66295992
55Non-homologous end-joining_Homo sapiens_hsa034500.64842430
56RNA degradation_Homo sapiens_hsa030180.64841366
57Regulation of autophagy_Homo sapiens_hsa041400.63095842
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.61865991
59T cell receptor signaling pathway_Homo sapiens_hsa046600.61591158
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61403239
61Ether lipid metabolism_Homo sapiens_hsa005650.61078256
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60780680
63Legionellosis_Homo sapiens_hsa051340.60187945
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.59896882
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58091488
66HTLV-I infection_Homo sapiens_hsa051660.58059072
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57501550
68beta-Alanine metabolism_Homo sapiens_hsa004100.56655632
69ECM-receptor interaction_Homo sapiens_hsa045120.56232948
70TGF-beta signaling pathway_Homo sapiens_hsa043500.54945211
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53691139
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53458780
73Gastric acid secretion_Homo sapiens_hsa049710.52338715
74Calcium signaling pathway_Homo sapiens_hsa040200.51405785
75Measles_Homo sapiens_hsa051620.51377910
76Phagosome_Homo sapiens_hsa041450.51238106
77Purine metabolism_Homo sapiens_hsa002300.51155643
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50637752
79Ovarian steroidogenesis_Homo sapiens_hsa049130.49668438
80DNA replication_Homo sapiens_hsa030300.48284294
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48104730
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47093483
83Small cell lung cancer_Homo sapiens_hsa052220.46982026
84Hepatitis B_Homo sapiens_hsa051610.46760630
85Glucagon signaling pathway_Homo sapiens_hsa049220.46519322
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42099739
87PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41491780
88Epstein-Barr virus infection_Homo sapiens_hsa051690.41484621
89Salivary secretion_Homo sapiens_hsa049700.40749293
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40160017
91Osteoclast differentiation_Homo sapiens_hsa043800.38715895
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37685696
93Starch and sucrose metabolism_Homo sapiens_hsa005000.37165386
94Basal cell carcinoma_Homo sapiens_hsa052170.35807203
95Rheumatoid arthritis_Homo sapiens_hsa053230.32917270
96Prostate cancer_Homo sapiens_hsa052150.32032003
97Insulin resistance_Homo sapiens_hsa049310.31069205
98Pyrimidine metabolism_Homo sapiens_hsa002400.29320066
99Tryptophan metabolism_Homo sapiens_hsa003800.27827595
100Wnt signaling pathway_Homo sapiens_hsa043100.27560797

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