OR2A20P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K36 demethylation (GO:0070544)5.21990783
2ribosome assembly (GO:0042255)4.35979055
3establishment of integrated proviral latency (GO:0075713)4.18044973
4regulation of posttranscriptional gene silencing (GO:0060147)4.05118899
5regulation of gene silencing by miRNA (GO:0060964)4.05118899
6regulation of gene silencing by RNA (GO:0060966)4.05118899
7positive regulation of SMAD protein import into nucleus (GO:0060391)4.04292208
8lactate metabolic process (GO:0006089)4.00001521
9negative regulation of phagocytosis (GO:0050765)3.74167048
10negative regulation of defense response to virus (GO:0050687)3.39683627
11ribosomal small subunit assembly (GO:0000028)3.31521492
12anterior/posterior axis specification, embryo (GO:0008595)3.28185769
13melanin biosynthetic process (GO:0042438)3.26270420
14secondary metabolite biosynthetic process (GO:0044550)3.24541009
15negative regulation of fibroblast apoptotic process (GO:2000270)3.19510671
16purine deoxyribonucleotide catabolic process (GO:0009155)3.16940603
17telomere maintenance via telomerase (GO:0007004)3.16605398
18regulation of SMAD protein import into nucleus (GO:0060390)3.15794669
19intra-S DNA damage checkpoint (GO:0031573)3.15623306
20mRNA cleavage (GO:0006379)3.14376946
21regulation of histone H3-K9 methylation (GO:0051570)3.09221271
22positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.03467277
23synapsis (GO:0007129)3.02761091
24heterochromatin organization (GO:0070828)3.01197027
25melanin metabolic process (GO:0006582)2.92648470
26response to X-ray (GO:0010165)2.91824340
27establishment of viral latency (GO:0019043)2.86357116
28nucleotide-sugar biosynthetic process (GO:0009226)2.85461672
29AMP metabolic process (GO:0046033)2.83407368
30regulation of gene silencing (GO:0060968)2.79264031
31deoxyribonucleotide catabolic process (GO:0009264)2.78549431
32kidney morphogenesis (GO:0060993)2.78090833
33positive regulation of uterine smooth muscle contraction (GO:0070474)2.77440855
34endothelium development (GO:0003158)2.75637252
35ribosomal large subunit biogenesis (GO:0042273)2.75361898
36regulation of chromatin silencing (GO:0031935)2.75256514
37translational termination (GO:0006415)2.71962629
38regulation of helicase activity (GO:0051095)2.71032416
39viral transcription (GO:0019083)2.69702289
40mitochondrial DNA replication (GO:0006264)2.68477498
41response to interferon-beta (GO:0035456)2.68451292
42single strand break repair (GO:0000012)2.66521264
43deoxyribose phosphate catabolic process (GO:0046386)2.66511230
44DNA double-strand break processing (GO:0000729)2.65727919
45multicellular organism reproduction (GO:0032504)2.65227111
46somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.62763668
47somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.62763668
48isotype switching (GO:0045190)2.62763668
49negative regulation of T cell apoptotic process (GO:0070233)2.61256767
50regulation of nuclear cell cycle DNA replication (GO:0033262)2.58012431
51paraxial mesoderm development (GO:0048339)2.57781114
52nodal signaling pathway (GO:0038092)2.54267093
53regulation of cell fate specification (GO:0042659)2.54086161
54regulation of fibroblast apoptotic process (GO:2000269)2.53753545
55regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.51528441
56regulation of mitotic spindle checkpoint (GO:1903504)2.51528441
57cellular response to zinc ion (GO:0071294)2.51011538
58formation of translation preinitiation complex (GO:0001731)2.50042199
59translational initiation (GO:0006413)2.48815999
60pre-miRNA processing (GO:0031054)2.47819456
61female gonad development (GO:0008585)2.46332195
62negative regulation of translational initiation (GO:0045947)2.45074887
63transcytosis (GO:0045056)2.44551640
64negative regulation of DNA-dependent DNA replication (GO:2000104)2.43906846
65double-strand break repair via nonhomologous end joining (GO:0006303)2.43468239
66non-recombinational repair (GO:0000726)2.43468239
67negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.42361927
68negative regulation of translation, ncRNA-mediated (GO:0040033)2.42361927
69regulation of translation, ncRNA-mediated (GO:0045974)2.42361927
70negative regulation of cell fate commitment (GO:0010454)2.42062775
71purine nucleobase biosynthetic process (GO:0009113)2.40833242
72antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.39998943
73regulation of gamma-delta T cell differentiation (GO:0045586)2.39710025
74translational elongation (GO:0006414)2.37946228
75protein targeting to ER (GO:0045047)2.37772963
76positive regulation of tolerance induction (GO:0002645)2.36846035
77telomere maintenance via telomere lengthening (GO:0010833)2.35292576
78SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.33695550
79mitotic G2 DNA damage checkpoint (GO:0007095)2.32821122
80positive regulation of protein autophosphorylation (GO:0031954)2.31236925
81nucleoside salvage (GO:0043174)2.30896742
82termination of RNA polymerase I transcription (GO:0006363)2.30651013
83pyrimidine nucleoside salvage (GO:0043097)2.30245268
84pyrimidine-containing compound salvage (GO:0008655)2.30245268
85negative regulation of JUN kinase activity (GO:0043508)2.29763196
86negative regulation of viral entry into host cell (GO:0046597)2.29436444
87IMP biosynthetic process (GO:0006188)2.29089501
88cotranslational protein targeting to membrane (GO:0006613)2.28382283
89establishment of protein localization to endoplasmic reticulum (GO:0072599)2.28084565
90mitotic G2/M transition checkpoint (GO:0044818)2.28047955
91RNA-dependent DNA replication (GO:0006278)2.27677274
92DNA replication initiation (GO:0006270)2.27437263
93antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.27387683
94C21-steroid hormone biosynthetic process (GO:0006700)2.26320109
95protein localization to endoplasmic reticulum (GO:0070972)2.23458448
96nucleobase biosynthetic process (GO:0046112)2.23127782
97negative regulation of cardiac muscle tissue development (GO:0055026)2.22728550
98regulation of stem cell maintenance (GO:2000036)2.22529297
99negative regulation of type I interferon production (GO:0032480)2.22364110
100negative regulation of telomerase activity (GO:0051974)2.22063760

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.44104903
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.27317039
3E2F7_22180533_ChIP-Seq_HELA_Human4.02363243
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.12810120
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.60192765
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.60192765
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.60192765
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.59172318
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.31553021
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.28644184
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.26824748
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.16798864
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.02606734
14FLI1_27457419_Chip-Seq_LIVER_Mouse1.96948895
15MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96207439
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.93793951
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84944906
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83413637
19ELK1_19687146_ChIP-ChIP_HELA_Human1.82066451
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.79224734
21MYB_26560356_Chip-Seq_TH2_Human1.73243460
22MYB_26560356_Chip-Seq_TH1_Human1.72441796
23E2F4_17652178_ChIP-ChIP_JURKAT_Human1.68748273
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.66921424
25VDR_23849224_ChIP-Seq_CD4+_Human1.63954081
26FOXP3_21729870_ChIP-Seq_TREG_Human1.62747885
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57286604
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56068307
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54546651
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50199802
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47486041
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46624036
33TCF3_18692474_ChIP-Seq_MEFs_Mouse1.44129770
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.38823641
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36925904
36FUS_26573619_Chip-Seq_HEK293_Human1.33543071
37GATA3_26560356_Chip-Seq_TH2_Human1.29576511
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28773744
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23471289
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.23206997
41CDX2_22108803_ChIP-Seq_LS180_Human1.22253185
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21600586
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21317221
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20136964
45FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18336263
46HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16486848
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15209796
48DCP1A_22483619_ChIP-Seq_HELA_Human1.14651560
49SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13556272
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13407401
51BRD4_25478319_ChIP-Seq_HGPS_Human1.12882867
52GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11516402
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11300105
54SPI1_23547873_ChIP-Seq_NB4_Human1.10748036
55NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.08948594
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.07801161
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07113697
58NANOG_16153702_ChIP-ChIP_HESCs_Human1.06633745
59CHD1_26751641_Chip-Seq_LNCaP_Human1.06314471
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.05624909
61CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05162928
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05081980
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05014828
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04313086
65ELF5_23300383_ChIP-Seq_T47D_Human1.04228883
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04062682
67EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03638168
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02990858
69NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02908221
70KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00586672
71JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99991356
72TCF3_18692474_ChIP-Seq_MESCs_Mouse0.99907626
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96528774
74EWS_26573619_Chip-Seq_HEK293_Human0.95377062
75TFEB_21752829_ChIP-Seq_HELA_Human0.95322388
76GATA3_27048872_Chip-Seq_THYMUS_Human0.95273060
77MYC_18940864_ChIP-ChIP_HL60_Human0.95093467
78POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94331035
79ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93713887
80MAF_26560356_Chip-Seq_TH2_Human0.92782387
81AR_21909140_ChIP-Seq_LNCAP_Human0.92187910
82MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90412461
83SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90205772
84HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.89389940
85CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.89290754
86PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.88906594
87P300_19829295_ChIP-Seq_ESCs_Human0.88891678
88HNFA_21074721_ChIP-Seq_CACO-2_Human0.88457393
89RUNX_20019798_ChIP-Seq_JUKART_Human0.88339093
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87952905
91PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87489642
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86880086
93TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85659988
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85252576
95NANOG_20526341_ChIP-Seq_ESCs_Human0.84353973
96ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.83898104
97SRF_21415370_ChIP-Seq_HL-1_Mouse0.82837842
98FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82692701
99ETV1_20927104_ChIP-Seq_GIST48_Human0.82507733
100STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.82167633

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat3.57059237
2MP0008057_abnormal_DNA_replication3.35993450
3MP0000372_irregular_coat_pigmentation2.99606339
4MP0005075_abnormal_melanosome_morpholog2.94704155
5MP0003763_abnormal_thymus_physiology2.36982207
6MP0002638_abnormal_pupillary_reflex2.32897272
7MP0003941_abnormal_skin_development2.32603773
8MP0008877_abnormal_DNA_methylation2.32195567
9MP0003806_abnormal_nucleotide_metabolis2.26606525
10MP0003279_aneurysm2.26109614
11MP0004272_abnormal_basement_membrane2.19777688
12MP0010368_abnormal_lymphatic_system2.16749270
13MP0008058_abnormal_DNA_repair2.15835830
14MP0004381_abnormal_hair_follicle1.95398975
15MP0002396_abnormal_hematopoietic_system1.90163316
16MP0003890_abnormal_embryonic-extraembry1.84809794
17MP0008438_abnormal_cutaneous_collagen1.69419807
18MP0008004_abnormal_stomach_pH1.66001981
19MP0004957_abnormal_blastocyst_morpholog1.65451339
20MP0003136_yellow_coat_color1.61361088
21MP0002138_abnormal_hepatobiliary_system1.53494082
22MP0009697_abnormal_copulation1.51895204
23MP0005408_hypopigmentation1.51724682
24MP0010094_abnormal_chromosome_stability1.51023966
25MP0001188_hyperpigmentation1.50760984
26MP0002796_impaired_skin_barrier1.49445729
27MP0003693_abnormal_embryo_hatching1.46645360
28MP0002277_abnormal_respiratory_mucosa1.45690266
29MP0004264_abnormal_extraembryonic_tissu1.43855658
30MP0002060_abnormal_skin_morphology1.42668788
31MP0002102_abnormal_ear_morphology1.41115439
32MP0005275_abnormal_skin_tensile1.40693819
33MP0010352_gastrointestinal_tract_polyps1.35831060
34MP0001542_abnormal_bone_strength1.32448747
35MP0001764_abnormal_homeostasis1.31880145
36MP0003195_calcinosis1.31726039
37MP0010386_abnormal_urinary_bladder1.22354457
38MP0003828_pulmonary_edema1.20774918
39MP0003077_abnormal_cell_cycle1.18445859
40MP0002166_altered_tumor_susceptibility1.17977846
41MP0000703_abnormal_thymus_morphology1.16292518
42MP0001849_ear_inflammation1.14101750
43MP0001730_embryonic_growth_arrest1.12270669
44MP0004185_abnormal_adipocyte_glucose1.11533432
45MP0004808_abnormal_hematopoietic_stem1.09650044
46MP0001661_extended_life_span1.06561789
47MP0009672_abnormal_birth_weight1.05597454
48MP0003718_maternal_effect1.05173343
49MP0002006_tumorigenesis1.03288475
50MP0003567_abnormal_fetal_cardiomyocyte1.03093193
51MP0000350_abnormal_cell_proliferation0.99429443
52MP0005174_abnormal_tail_pigmentation0.96082997
53MP0002933_joint_inflammation0.94620020
54MP0001835_abnormal_antigen_presentation0.92820617
55MP0001984_abnormal_olfaction0.92786632
56MP0002009_preneoplasia0.90904279
57MP0005379_endocrine/exocrine_gland_phen0.90454084
58MP0003111_abnormal_nucleus_morphology0.89943871
59MP0005023_abnormal_wound_healing0.89125016
60MP0003011_delayed_dark_adaptation0.88537074
61MP0002998_abnormal_bone_remodeling0.87889168
62MP0009333_abnormal_splenocyte_physiolog0.87697106
63MP0008007_abnormal_cellular_replicative0.87390705
64MP0009703_decreased_birth_body0.87244908
65MP0002398_abnormal_bone_marrow0.84970497
66MP0002160_abnormal_reproductive_system0.84812556
67MP0009384_cardiac_valve_regurgitation0.83997803
68MP0003950_abnormal_plasma_membrane0.83042439
69MP0000371_diluted_coat_color0.82650502
70MP0002938_white_spotting0.80101693
71MP0002019_abnormal_tumor_incidence0.79380395
72MP0002132_abnormal_respiratory_system0.79029930
73MP0001672_abnormal_embryogenesis/_devel0.78565321
74MP0005380_embryogenesis_phenotype0.78565321
75MP0005171_absent_coat_pigmentation0.77985654
76MP0003936_abnormal_reproductive_system0.76796023
77MP0008260_abnormal_autophagy0.76001883
78MP0001819_abnormal_immune_cell0.75652407
79MP0002420_abnormal_adaptive_immunity0.75574279
80MP0005595_abnormal_vascular_smooth0.75197656
81MP0002163_abnormal_gland_morphology0.74911674
82MP0003186_abnormal_redox_activity0.74093229
83MP0005503_abnormal_tendon_morphology0.73975547
84MP0009379_abnormal_foot_pigmentation0.71903134
85MP0002084_abnormal_developmental_patter0.71005971
86MP0005671_abnormal_response_to0.70040409
87MP0000432_abnormal_head_morphology0.68620668
88MP0002086_abnormal_extraembryonic_tissu0.68036146
89MP0005501_abnormal_skin_physiology0.67565436
90MP0002095_abnormal_skin_pigmentation0.67020197
91MP0002088_abnormal_embryonic_growth/wei0.66774441
92MP0000689_abnormal_spleen_morphology0.66350890
93MP0001853_heart_inflammation0.66261211
94MP0010030_abnormal_orbit_morphology0.65118327
95MP0000015_abnormal_ear_pigmentation0.64811783
96MP0000477_abnormal_intestine_morphology0.63890973
97MP0002722_abnormal_immune_system0.63185886
98MP0001243_abnormal_dermal_layer0.62937926
99MP0006054_spinal_hemorrhage0.62781541
100MP0000627_abnormal_mammary_gland0.62519755

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)4.67857220
2Pancreatic islet-cell hyperplasia (HP:0004510)3.58460028
3Colon cancer (HP:0003003)3.56312641
4Aortic aneurysm (HP:0004942)3.39866846
5Abnormality of the pancreatic islet cells (HP:0006476)3.24295755
6Abnormality of endocrine pancreas physiology (HP:0012093)3.24295755
7Chronic bronchitis (HP:0004469)3.17834701
8Sensory axonal neuropathy (HP:0003390)3.16569274
9Gonadotropin excess (HP:0000837)3.12948101
10Thrombocytosis (HP:0001894)3.12429932
11Reduced antithrombin III activity (HP:0001976)3.10495184
12Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.05118544
13Aplastic anemia (HP:0001915)2.94102287
14Hematochezia (HP:0002573)2.91323893
15Chromsome breakage (HP:0040012)2.88557030
16Abnormality of aspartate family amino acid metabolism (HP:0010899)2.79823755
17Dyschromatopsia (HP:0007641)2.70782576
18Hypoglycemic seizures (HP:0002173)2.62418521
19Abnormality of methionine metabolism (HP:0010901)2.62187202
20Basal cell carcinoma (HP:0002671)2.62045813
21Abnormality of the columella (HP:0009929)2.61707541
22IgM deficiency (HP:0002850)2.60187134
23Abnormality of the dental pulp (HP:0006479)2.53487624
24Abnormality of chromosome stability (HP:0003220)2.53282844
25Neonatal hypoglycemia (HP:0001998)2.42374388
26Bilateral sensorineural hearing impairment (HP:0008619)2.41092942
27Abnormality of dentin (HP:0010299)2.38531918
28Bronchitis (HP:0012387)2.37879800
29Biliary tract neoplasm (HP:0100574)2.37450112
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.34063742
31Premature loss of primary teeth (HP:0006323)2.32227388
32Abnormality of the frontal sinuses (HP:0002687)2.29822880
33Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.24861023
34Increased hepatocellular lipid droplets (HP:0006565)2.24333895
35Nephroblastoma (Wilms tumor) (HP:0002667)2.24326591
36Autoimmune hemolytic anemia (HP:0001890)2.22141372
37Clubbing of toes (HP:0100760)2.20300244
38Papilledema (HP:0001085)2.19892205
39Diastasis recti (HP:0001540)2.19180225
40Ureteral duplication (HP:0000073)2.18357925
41Narrow nasal bridge (HP:0000446)2.17716136
42Lymphopenia (HP:0001888)2.15278271
43Lipid accumulation in hepatocytes (HP:0006561)2.14116723
44Panhypogammaglobulinemia (HP:0003139)2.13574293
45Embryonal renal neoplasm (HP:0011794)2.12796225
46Septo-optic dysplasia (HP:0100842)2.11908176
47Selective tooth agenesis (HP:0001592)2.11224108
48Cutaneous melanoma (HP:0012056)2.06447709
49Abnormality of the ileum (HP:0001549)2.03807002
50Duplicated collecting system (HP:0000081)2.03578249
51Squamous cell carcinoma (HP:0002860)2.01616334
52Short middle phalanx of the 5th finger (HP:0004220)1.99708636
53Meckel diverticulum (HP:0002245)1.98967685
54Prominent metopic ridge (HP:0005487)1.97950576
55White forelock (HP:0002211)1.96395516
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96290428
57Abnormal protein N-linked glycosylation (HP:0012347)1.96290428
58Abnormal protein glycosylation (HP:0012346)1.96290428
59Abnormal glycosylation (HP:0012345)1.96290428
60Absent thumb (HP:0009777)1.94191185
61Abnormality of the renal collecting system (HP:0004742)1.94073829
62Short hallux (HP:0010109)1.92567507
63Spontaneous hematomas (HP:0007420)1.92211324
64Abnormality of DNA repair (HP:0003254)1.91245144
65Absent rod-and cone-mediated responses on ERG (HP:0007688)1.89952702
66Aplasia cutis congenita (HP:0001057)1.89602433
67Abnormality of cells of the lymphoid lineage (HP:0012140)1.89266699
68Median cleft lip (HP:0000161)1.88678856
69Abnormality of the preputium (HP:0100587)1.87149566
70Abnormal delayed hypersensitivity skin test (HP:0002963)1.86064375
71T lymphocytopenia (HP:0005403)1.86042160
72Abnormal hair whorl (HP:0010721)1.85956096
73Microcytic anemia (HP:0001935)1.84540331
74Rhabdomyosarcoma (HP:0002859)1.84450314
75Recurrent bronchitis (HP:0002837)1.82910805
76Aqueductal stenosis (HP:0002410)1.82869842
77Inflammation of the large intestine (HP:0002037)1.82084873
78Type I transferrin isoform profile (HP:0003642)1.81731434
79Chronic sinusitis (HP:0011109)1.81085360
80Aplasia/Hypoplasia of the uvula (HP:0010293)1.80976146
81Stenosis of the external auditory canal (HP:0000402)1.79551075
82Reticulocytopenia (HP:0001896)1.78205595
83Hyperglycemia (HP:0003074)1.77258540
84Abnormal pancreas size (HP:0012094)1.75250224
85Premature ovarian failure (HP:0008209)1.74102841
86Genu recurvatum (HP:0002816)1.73027720
87Aplasia/Hypoplasia of the macula (HP:0008059)1.68728433
88Multiple enchondromatosis (HP:0005701)1.66768920
89Macrocytic anemia (HP:0001972)1.66754520
90Aplasia/Hypoplasia of the spleen (HP:0010451)1.66422359
91Abnormality of T cell number (HP:0011839)1.65844844
92Aplasia/Hypoplasia of the hallux (HP:0008362)1.65177030
93Abnormality of the vitamin B12 metabolism (HP:0004341)1.64760871
94Hypoplasia of the fovea (HP:0007750)1.64405875
95Aplasia/Hypoplasia of the fovea (HP:0008060)1.64405875
96Asplenia (HP:0001746)1.64149210
97Symptomatic seizures (HP:0011145)1.64062129
98Colitis (HP:0002583)1.64000702
99Generalized hypotonia (HP:0001290)1.63344416
100Mixed hearing impairment (HP:0000410)1.62149013

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.34341062
2PASK3.76417860
3MST43.60992889
4NLK3.29290352
5TAF13.20305456
6TNIK2.69044552
7STK38L2.64741057
8MYLK2.32246794
9PBK2.31853678
10MARK32.25271210
11MAP3K102.09362620
12CDK192.08263019
13NUAK12.04172131
14SIK31.98252732
15STK241.90600075
16TXK1.80741089
17MAP4K11.73295913
18TIE11.70751856
19VRK21.69974156
20ACVR1B1.67475007
21BRSK21.63790047
22FRK1.60783483
23NEK21.53424702
24STK31.50636921
25KIT1.36843765
26MELK1.29962927
27FGFR21.22552376
28MKNK21.22174424
29PLK31.21091012
30CDK31.19466477
31MUSK1.18317922
32PRKG21.14034390
33EIF2AK31.09006389
34CDC71.06721998
35PLK41.05220206
36MKNK11.02208211
37PINK11.00566848
38TSSK60.99245216
39TGFBR10.98190216
40KDR0.91495028
41ITK0.91301229
42FGR0.88954067
43TTK0.88185250
44PRKCQ0.83944888
45ZAP700.83120032
46DYRK30.82236756
47ERBB40.82066672
48TEC0.79689336
49TAOK30.73766343
50FGFR10.72857155
51OXSR10.68984914
52BMPR1B0.68750657
53NME20.67111458
54PLK10.66886365
55IKBKE0.65653335
56TGFBR20.65394828
57GRK10.64516547
58VRK10.64243509
59TYK20.64131598
60ALK0.61826049
61LATS20.60694718
62WEE10.60199531
63EGFR0.59943892
64ZAK0.58372030
65BTK0.57287505
66PRPF4B0.55285795
67CSK0.53809462
68RPS6KA40.53024909
69JAK30.51857044
70MAP3K120.51648928
71LCK0.50670177
72STK380.50088923
73SMG10.49747928
74TRIM280.49589054
75GRK60.48591933
76IRAK40.48243160
77TESK20.47391265
78BMX0.46521809
79SIK10.45975210
80MAP3K30.45051253
81MAP3K60.44937345
82CHEK10.44372292
83STK100.43446724
84CSF1R0.41041143
85MAP3K90.40308098
86TBK10.39336609
87PDGFRB0.39131290
88IGF1R0.38852801
89PTK2B0.38688959
90FLT30.38514335
91HIPK20.38261815
92IRAK20.37282516
93PRKCH0.35560635
94MST1R0.34215493
95CDC42BPA0.33891679
96PAK10.31699606
97JAK10.31101681
98CSNK1G10.29907419
99PAK40.28598197
100PTK20.27516315

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.15391856
2Ribosome_Homo sapiens_hsa030103.13003608
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.92896196
4Proteasome_Homo sapiens_hsa030502.78212590
5RNA polymerase_Homo sapiens_hsa030202.55513203
6One carbon pool by folate_Homo sapiens_hsa006702.34472650
7RNA degradation_Homo sapiens_hsa030182.34109093
8Primary immunodeficiency_Homo sapiens_hsa053402.14351194
9DNA replication_Homo sapiens_hsa030302.04852498
10RNA transport_Homo sapiens_hsa030131.90842338
11Base excision repair_Homo sapiens_hsa034101.86354850
12Pyruvate metabolism_Homo sapiens_hsa006201.76072619
13Basal transcription factors_Homo sapiens_hsa030221.68612153
14Homologous recombination_Homo sapiens_hsa034401.66704329
15Pyrimidine metabolism_Homo sapiens_hsa002401.61285732
16Mismatch repair_Homo sapiens_hsa034301.59182630
17Cysteine and methionine metabolism_Homo sapiens_hsa002701.58112018
18Selenocompound metabolism_Homo sapiens_hsa004501.55291990
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49732204
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48883078
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.35598113
22Thyroid cancer_Homo sapiens_hsa052161.35553489
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.34130977
24Glutathione metabolism_Homo sapiens_hsa004801.32489098
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.31781564
26Folate biosynthesis_Homo sapiens_hsa007901.30550979
27Chemical carcinogenesis_Homo sapiens_hsa052041.29544674
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29360273
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24516736
30Linoleic acid metabolism_Homo sapiens_hsa005911.18859212
31Purine metabolism_Homo sapiens_hsa002301.16207920
32Fanconi anemia pathway_Homo sapiens_hsa034601.13685952
33Retinol metabolism_Homo sapiens_hsa008301.12750581
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.11766511
35Vitamin digestion and absorption_Homo sapiens_hsa049771.10275194
36Phototransduction_Homo sapiens_hsa047441.09868233
37Arachidonic acid metabolism_Homo sapiens_hsa005901.07043724
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06227317
39Propanoate metabolism_Homo sapiens_hsa006401.05521015
40Nucleotide excision repair_Homo sapiens_hsa034201.05106726
41T cell receptor signaling pathway_Homo sapiens_hsa046601.01638304
42Olfactory transduction_Homo sapiens_hsa047401.00035455
43Glycerophospholipid metabolism_Homo sapiens_hsa005640.99012596
44Regulation of autophagy_Homo sapiens_hsa041400.98516276
45Circadian rhythm_Homo sapiens_hsa047100.97338200
46Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97056233
47Cell cycle_Homo sapiens_hsa041100.94428300
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93730573
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92607106
50Prostate cancer_Homo sapiens_hsa052150.92598354
51Wnt signaling pathway_Homo sapiens_hsa043100.92049596
52Spliceosome_Homo sapiens_hsa030400.85250208
53Adherens junction_Homo sapiens_hsa045200.83951726
54Fatty acid degradation_Homo sapiens_hsa000710.80483911
55mRNA surveillance pathway_Homo sapiens_hsa030150.79804638
56Measles_Homo sapiens_hsa051620.75573573
57Ether lipid metabolism_Homo sapiens_hsa005650.75203136
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73141557
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.69918679
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.68743124
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.68589553
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.68159701
63Basal cell carcinoma_Homo sapiens_hsa052170.67114390
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65873565
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65747448
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65631961
67p53 signaling pathway_Homo sapiens_hsa041150.64656874
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.63042293
69Platelet activation_Homo sapiens_hsa046110.62569854
70Herpes simplex infection_Homo sapiens_hsa051680.61052312
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60109149
72Butanoate metabolism_Homo sapiens_hsa006500.59939951
73Tight junction_Homo sapiens_hsa045300.58706843
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58607851
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54659043
76Glycerolipid metabolism_Homo sapiens_hsa005610.54141334
77Hematopoietic cell lineage_Homo sapiens_hsa046400.53310772
78Peroxisome_Homo sapiens_hsa041460.51992485
79HTLV-I infection_Homo sapiens_hsa051660.49797848
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48673581
81TGF-beta signaling pathway_Homo sapiens_hsa043500.48269643
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46583246
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.46182821
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45465940
85Pathways in cancer_Homo sapiens_hsa052000.42817637
86Oocyte meiosis_Homo sapiens_hsa041140.42541925
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40694958
88Protein digestion and absorption_Homo sapiens_hsa049740.40352683
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40150832
90Tyrosine metabolism_Homo sapiens_hsa003500.40105423
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40057571
92Fatty acid elongation_Homo sapiens_hsa000620.40016953
93Metabolic pathways_Homo sapiens_hsa011000.38192199
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37942771
95Sphingolipid metabolism_Homo sapiens_hsa006000.37414625
96Nitrogen metabolism_Homo sapiens_hsa009100.37391728
97Shigellosis_Homo sapiens_hsa051310.34452404
98Taste transduction_Homo sapiens_hsa047420.34371636
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32194237
100Fat digestion and absorption_Homo sapiens_hsa049750.31822824

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