OR2A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of dendrite morphogenesis (GO:0050774)6.56958219
2maintenance of gastrointestinal epithelium (GO:0030277)6.29663823
3nephron tubule formation (GO:0072079)5.59887402
4protein K11-linked deubiquitination (GO:0035871)5.54500409
5Rap protein signal transduction (GO:0032486)5.52444916
6protein targeting to Golgi (GO:0000042)5.29537594
7epithelial structure maintenance (GO:0010669)5.15393672
8positive regulation of protein autophosphorylation (GO:0031954)5.06591014
9establishment of protein localization to Golgi (GO:0072600)5.02396274
10retrograde transport, vesicle recycling within Golgi (GO:0000301)4.79825123
11O-glycan processing (GO:0016266)4.47748542
12detection of light stimulus involved in sensory perception (GO:0050962)4.38453871
13detection of light stimulus involved in visual perception (GO:0050908)4.38453871
14positive regulation of guanylate cyclase activity (GO:0031284)4.28000289
15lactate metabolic process (GO:0006089)4.25001235
16fucose catabolic process (GO:0019317)4.06398236
17L-fucose metabolic process (GO:0042354)4.06398236
18L-fucose catabolic process (GO:0042355)4.06398236
19regulation of guanylate cyclase activity (GO:0031282)3.96465564
20multicellular organism reproduction (GO:0032504)3.90737028
21positive regulation of prostaglandin secretion (GO:0032308)3.90174569
22single strand break repair (GO:0000012)3.89675502
23protein localization to Golgi apparatus (GO:0034067)3.87566345
24regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.80179313
25protein polyglutamylation (GO:0018095)3.74665246
26regulation of podosome assembly (GO:0071801)3.73846687
27negative regulation of bone resorption (GO:0045779)3.68388838
28myoblast migration (GO:0051451)3.63293715
29negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.60917422
30positive regulation of natural killer cell differentiation (GO:0032825)3.58054827
31retinal metabolic process (GO:0042574)3.53713261
32otic vesicle formation (GO:0030916)3.46098040
33protein O-linked glycosylation (GO:0006493)3.42047197
34positive regulation of extracellular matrix organization (GO:1903055)3.31992644
35positive regulation of digestive system process (GO:0060456)3.31184794
36eye photoreceptor cell differentiation (GO:0001754)3.29989180
37photoreceptor cell differentiation (GO:0046530)3.29989180
38thyroid gland development (GO:0030878)3.25652330
39pseudouridine synthesis (GO:0001522)3.21963553
40negative regulation of fatty acid biosynthetic process (GO:0045717)3.18757116
41* detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.17199980
42centriole replication (GO:0007099)3.16964012
43positive regulation of male gonad development (GO:2000020)3.16122234
44negative regulation of viral release from host cell (GO:1902187)3.15605804
45negative regulation of dendrite development (GO:2000171)3.06111117
46regulation of mesenchymal cell apoptotic process (GO:2001053)3.05256535
47nephron epithelium morphogenesis (GO:0072088)3.05224720
48nephron tubule morphogenesis (GO:0072078)3.05224720
49regulation of apoptotic process involved in morphogenesis (GO:1902337)3.04099714
50keratinocyte proliferation (GO:0043616)3.03308614
51regulation of prostaglandin secretion (GO:0032306)3.01121694
52regulation of acrosome reaction (GO:0060046)2.99297757
53regulation of male gonad development (GO:2000018)2.94441704
54sperm motility (GO:0030317)2.94091147
55sodium-independent organic anion transport (GO:0043252)2.93886154
56terpenoid biosynthetic process (GO:0016114)2.93397561
57sleep (GO:0030431)2.92917766
58tyrosine metabolic process (GO:0006570)2.92296921
59Sertoli cell development (GO:0060009)2.89000944
60negative regulation of calcium ion transport into cytosol (GO:0010523)2.85934911
61negative regulation of JUN kinase activity (GO:0043508)2.84408617
62keratinocyte development (GO:0003334)2.84148094
63fucosylation (GO:0036065)2.83538540
64mitotic G2 DNA damage checkpoint (GO:0007095)2.82953379
65regulation of respiratory burst (GO:0060263)2.82672831
66rRNA catabolic process (GO:0016075)2.82515454
67amine catabolic process (GO:0009310)2.80803968
68cellular biogenic amine catabolic process (GO:0042402)2.80803968
69phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.80593326
70organic cation transport (GO:0015695)2.79366731
71regulation of protein autophosphorylation (GO:0031952)2.78365667
72regulation of ARF GTPase activity (GO:0032312)2.77705733
73amine biosynthetic process (GO:0009309)2.77569533
74regulation of memory T cell differentiation (GO:0043380)2.76894455
75proline biosynthetic process (GO:0006561)2.75624616
76positive regulation of cGMP biosynthetic process (GO:0030828)2.74811760
77protein K63-linked deubiquitination (GO:0070536)2.74293362
78regulation of bile acid biosynthetic process (GO:0070857)2.74104323
79positive regulation of DNA-templated transcription, initiation (GO:2000144)2.73301775
80negative regulation of viral entry into host cell (GO:0046597)2.70439865
81regulation of viral entry into host cell (GO:0046596)2.67730866
82regulation of cGMP biosynthetic process (GO:0030826)2.62957645
83regulation of regulatory T cell differentiation (GO:0045589)2.62497627
84negative regulation of bone remodeling (GO:0046851)2.61447452
85positive regulation of cell size (GO:0045793)2.61368478
86protein K48-linked deubiquitination (GO:0071108)2.61268612
87cobalamin metabolic process (GO:0009235)2.61055402
88regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.60644311
89heart valve morphogenesis (GO:0003179)2.59134017
90single fertilization (GO:0007338)2.58396201
91mitotic G2/M transition checkpoint (GO:0044818)2.58275313
92positive regulation of icosanoid secretion (GO:0032305)2.57315352
93reproduction (GO:0000003)2.56534304
94polyamine biosynthetic process (GO:0006596)2.56414881
95regulation of viral release from host cell (GO:1902186)2.53682399
96S-adenosylmethionine metabolic process (GO:0046500)2.53344553
97fusion of sperm to egg plasma membrane (GO:0007342)2.51891307
98cellular biogenic amine biosynthetic process (GO:0042401)2.50540991
99positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.49342761
100DNA double-strand break processing (GO:0000729)2.48353570

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_15608294_ChIP-ChIP_MCF-7_Human3.69481441
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.54592478
3CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.49396817
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.47400947
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.29258699
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.24817692
7ESR1_20079471_ChIP-ChIP_T-47D_Human3.22793869
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.13108922
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.87110281
10CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.86338251
11FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.84766690
12ER_23166858_ChIP-Seq_MCF-7_Human2.71565302
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.36664967
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.29920642
15TCF4_18268006_ChIP-ChIP_LS174T_Human2.25520192
16ZNF217_24962896_ChIP-Seq_MCF-7_Human2.19881836
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.10479565
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.06958709
19ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.99538740
20GATA1_22025678_ChIP-Seq_K562_Human1.92832600
21RXR_22108803_ChIP-Seq_LS180_Human1.89988094
22GATA4_25053715_ChIP-Seq_YYC3_Human1.88226286
23* CJUN_26792858_Chip-Seq_BT549_Human1.85611812
24HOXB7_26014856_ChIP-Seq_BT474_Human1.84429255
25CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.80894576
26GATA6_25053715_ChIP-Seq_YYC3_Human1.79866709
27SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.74400373
28SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.74400373
29VDR_22108803_ChIP-Seq_LS180_Human1.69225141
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.67973245
31GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.67851266
32AR_21572438_ChIP-Seq_LNCaP_Human1.65692679
33RUNX1_27514584_Chip-Seq_MCF-7_Human1.65251666
34TDRD3_21172665_ChIP-Seq_MCF-7_Human1.64226967
35PPAR_26484153_Chip-Seq_NCI-H1993_Human1.62649958
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.58837974
37GATA3_26560356_Chip-Seq_TH2_Human1.54990965
38* CDX2_22108803_ChIP-Seq_LS180_Human1.53470413
39CDX2_20551321_ChIP-Seq_CACO-2_Human1.52145666
40HNFA_21074721_ChIP-Seq_CACO-2_Human1.51961418
41GATA3_24758297_ChIP-Seq_MCF-7_Human1.51095989
42FOXM1_26456572_ChIP-Seq_MCF-7_Human1.51013040
43RBPJ_21746931_ChIP-Seq_IB4_Human1.49529926
44PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.48845580
45DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.45129513
46PHF8_20622853_ChIP-Seq_HELA_Human1.45041060
47NFYB_21822215_ChIP-Seq_K562_Human1.43993993
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42734600
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.40563106
50WDR5_24793694_ChIP-Seq_LNCAP_Human1.40140143
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38955829
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.38763570
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.38035669
54GATA1_19941826_ChIP-Seq_K562_Human1.37582573
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36517425
56GATA6_21074721_ChIP-Seq_CACO-2_Human1.36052261
57HIF1A_21447827_ChIP-Seq_MCF-7_Human1.35468702
58JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35198556
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35017640
60GATA2_19941826_ChIP-Seq_K562_Human1.34742955
61TBL1_22424771_ChIP-Seq_293T_Human1.34626610
62CBP_20019798_ChIP-Seq_JUKART_Human1.33883046
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33883046
64ETV1_20927104_ChIP-Seq_GIST48_Human1.33090364
65ZNF274_21170338_ChIP-Seq_K562_Hela1.31904878
66AHR_22903824_ChIP-Seq_MCF-7_Human1.27020520
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26763169
68NFYA_21822215_ChIP-Seq_K562_Human1.25042754
69FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22327765
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.21403450
71PKCTHETA_26484144_Chip-Seq_BREAST_Human1.21147533
72FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.19282701
73ERA_21632823_ChIP-Seq_H3396_Human1.18208787
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.15803598
75JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15626554
76FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15137798
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13459540
78TP53_18474530_ChIP-ChIP_U2OS_Human1.12703232
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.10504070
80SCL_19346495_ChIP-Seq_HPC-7_Human1.08646341
81SPI1_23127762_ChIP-Seq_K562_Human1.08534078
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07173924
83TCF4_22108803_ChIP-Seq_LS180_Human1.05992375
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05992343
85CBX2_22325352_ChIP-Seq_293T-Rex_Human1.05927819
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03733965
87TP53_16413492_ChIP-PET_HCT116_Human1.02892935
88PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02762685
89VDR_24787735_ChIP-Seq_THP-1_Human1.01255509
90STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00862399
91FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.00835914
92NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99711328
93* GATA3_21878914_ChIP-Seq_MCF-7_Human0.99580429
94P300_19829295_ChIP-Seq_ESCs_Human0.99567200
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99381783
96MYB_26560356_Chip-Seq_TH2_Human0.98414080
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98024998
98FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97860967
99FOXA1_25329375_ChIP-Seq_VCAP_Human0.97860967
100* BCAT_22108803_ChIP-Seq_LS180_Human0.97503991

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose4.51126213
2MP0003195_calcinosis3.78164646
3MP0008995_early_reproductive_senescence3.77758569
4MP0002138_abnormal_hepatobiliary_system3.51651224
5MP0008057_abnormal_DNA_replication3.40886471
6MP0002139_abnormal_hepatobiliary_system3.24835455
7MP0003950_abnormal_plasma_membrane3.13208968
8MP0005083_abnormal_biliary_tract2.94819773
9MP0003806_abnormal_nucleotide_metabolis2.51886612
10MP0005410_abnormal_fertilization2.34517943
11MP0003878_abnormal_ear_physiology2.22261559
12MP0005377_hearing/vestibular/ear_phenot2.22261559
13MP0001666_abnormal_nutrient_absorption2.18546139
14MP0005647_abnormal_sex_gland2.06427457
15MP0000372_irregular_coat_pigmentation2.05617237
16MP0001485_abnormal_pinna_reflex2.02020635
17MP0003866_abnormal_defecation1.95363189
18MP0002735_abnormal_chemical_nociception1.94949756
19MP0005551_abnormal_eye_electrophysiolog1.92937612
20MP0001873_stomach_inflammation1.90450948
21MP0002132_abnormal_respiratory_system1.90105011
22MP0003786_premature_aging1.84415219
23MP0004264_abnormal_extraembryonic_tissu1.82672457
24MP0002166_altered_tumor_susceptibility1.80441616
25MP0008058_abnormal_DNA_repair1.79861117
26MP0004147_increased_porphyrin_level1.77603737
27MP0003252_abnormal_bile_duct1.70043606
28MP0006276_abnormal_autonomic_nervous1.54923714
29MP0000613_abnormal_salivary_gland1.54584321
30MP0000465_gastrointestinal_hemorrhage1.52590940
31MP0009278_abnormal_bone_marrow1.50714755
32MP0003718_maternal_effect1.49019091
33MP0002148_abnormal_hypersensitivity_rea1.42518607
34MP0005451_abnormal_body_composition1.42056419
35MP0000678_abnormal_parathyroid_gland1.40709933
36MP0001529_abnormal_vocalization1.40653984
37MP0005310_abnormal_salivary_gland1.40289966
38MP0005671_abnormal_response_to1.37655039
39MP0002282_abnormal_trachea_morphology1.35901168
40MP0010386_abnormal_urinary_bladder1.35699737
41MP0002277_abnormal_respiratory_mucosa1.34985453
42MP0001270_distended_abdomen1.34934361
43MP0008872_abnormal_physiological_respon1.32160153
44MP0005167_abnormal_blood-brain_barrier1.30837116
45MP0009840_abnormal_foam_cell1.30491956
46MP0001765_abnormal_ion_homeostasis1.28454186
47MP0000749_muscle_degeneration1.27090722
48MP0010155_abnormal_intestine_physiology1.25374869
49MP0003828_pulmonary_edema1.23013995
50MP0001501_abnormal_sleep_pattern1.20139534
51MP0005395_other_phenotype1.17891807
52MP0009643_abnormal_urine_homeostasis1.12631342
53MP0004019_abnormal_vitamin_homeostasis1.11386860
54MP0004947_skin_inflammation1.10957442
55MP0001502_abnormal_circadian_rhythm1.08985598
56MP0001542_abnormal_bone_strength1.07120167
57MP0005332_abnormal_amino_acid1.06129714
58MP0002168_other_aberrant_phenotype1.05203148
59MP0001929_abnormal_gametogenesis1.02539452
60MP0003123_paternal_imprinting1.01627612
61MP0002136_abnormal_kidney_physiology0.99097326
62MP0008875_abnormal_xenobiotic_pharmacok0.98785554
63MP0002249_abnormal_larynx_morphology0.97358546
64MP0000538_abnormal_urinary_bladder0.97196963
65MP0009785_altered_susceptibility_to0.95864120
66MP0003943_abnormal_hepatobiliary_system0.95729053
67MP0001881_abnormal_mammary_gland0.93591487
68MP0002006_tumorigenesis0.91672956
69MP0005000_abnormal_immune_tolerance0.90002434
70MP0002127_abnormal_cardiovascular_syste0.88257664
71MP0003045_fibrosis0.87409694
72MP0001661_extended_life_span0.86456659
73MP0001800_abnormal_humoral_immune0.86232420
74MP0008775_abnormal_heart_ventricle0.85516450
75MP0002928_abnormal_bile_duct0.83437098
76MP0003698_abnormal_male_reproductive0.83018731
77MP0001545_abnormal_hematopoietic_system0.82608247
78MP0005397_hematopoietic_system_phenotyp0.82608247
79MP0005636_abnormal_mineral_homeostasis0.82558234
80MP0008961_abnormal_basal_metabolism0.77941512
81MP0004782_abnormal_surfactant_physiolog0.76611495
82MP0000685_abnormal_immune_system0.75100265
83MP0000230_abnormal_systemic_arterial0.74502227
84MP0004272_abnormal_basement_membrane0.73417760
85MP0004084_abnormal_cardiac_muscle0.73010037
86MP0003879_abnormal_hair_cell0.71052469
87MP0004085_abnormal_heartbeat0.69747535
88MP0002693_abnormal_pancreas_physiology0.68818582
89MP0002160_abnormal_reproductive_system0.68110766
90MP0003724_increased_susceptibility_to0.67908542
91MP0004742_abnormal_vestibular_system0.67869636
92MP0002108_abnormal_muscle_morphology0.67477172
93MP0008004_abnormal_stomach_pH0.65815762
94MP0008007_abnormal_cellular_replicative0.64008578
95MP0002452_abnormal_antigen_presenting0.63989318
96MP0002210_abnormal_sex_determination0.62989249
97MP0001853_heart_inflammation0.61047252
98MP0000653_abnormal_sex_gland0.60735944
99MP0002876_abnormal_thyroid_physiology0.60381747
100MP0003936_abnormal_reproductive_system0.59101776

Predicted human phenotypes

RankGene SetZ-score
1Follicular hyperkeratosis (HP:0007502)5.03095430
2Alopecia of scalp (HP:0002293)4.52369402
3Posterior subcapsular cataract (HP:0007787)4.00328690
411 pairs of ribs (HP:0000878)3.93578359
5Tubulointerstitial nephritis (HP:0001970)3.88495448
6Elevated erythrocyte sedimentation rate (HP:0003565)3.77076497
7Hypophosphatemic rickets (HP:0004912)3.72955303
8Subcapsular cataract (HP:0000523)3.65362467
9Abnormality of dental color (HP:0011073)3.56670155
10True hermaphroditism (HP:0010459)3.52169774
11Conjugated hyperbilirubinemia (HP:0002908)3.39232130
12Abnormality of male internal genitalia (HP:0000022)3.25981921
13Pili torti (HP:0003777)3.22360926
14Chronic diarrhea (HP:0002028)3.14950075
15Aplasia cutis congenita (HP:0001057)3.02568850
16Sensory axonal neuropathy (HP:0003390)2.95117051
17Congenital, generalized hypertrichosis (HP:0004540)2.81976430
18Petechiae (HP:0000967)2.77881123
19Lip pit (HP:0100267)2.74233473
20Stomatitis (HP:0010280)2.72164897
21Ileus (HP:0002595)2.69051639
22Hypoplastic iliac wings (HP:0002866)2.67975736
23Atonic seizures (HP:0010819)2.67967000
24Sparse eyelashes (HP:0000653)2.67727710
25Type II lissencephaly (HP:0007260)2.66849967
26Gaze-evoked nystagmus (HP:0000640)2.65977840
27Hepatocellular carcinoma (HP:0001402)2.62105677
28Pancreatic cysts (HP:0001737)2.52865695
29Tibial bowing (HP:0002982)2.50283885
30Hyperkalemia (HP:0002153)2.49324381
31Tubular atrophy (HP:0000092)2.44655849
32Abnormality of the nasal septum (HP:0000419)2.39071401
33Ectropion (HP:0000656)2.37533184
34Pancreatic fibrosis (HP:0100732)2.35986797
35Abnormality of macular pigmentation (HP:0008002)2.35111989
36Duplicated collecting system (HP:0000081)2.34858677
37Cystic liver disease (HP:0006706)2.34512330
38Microretrognathia (HP:0000308)2.33514273
39Diaphragmatic weakness (HP:0009113)2.32329174
40Autoimmune hemolytic anemia (HP:0001890)2.32311224
41Male pseudohermaphroditism (HP:0000037)2.31957394
42Sex reversal (HP:0012245)2.30501823
43Abnormal sex determination (HP:0012244)2.30501823
44Chronic hepatic failure (HP:0100626)2.30152400
45Neonatal short-limb short stature (HP:0008921)2.29875955
46Abnormality of the aortic arch (HP:0012303)2.28754258
47Testicular atrophy (HP:0000029)2.28609133
48IgG deficiency (HP:0004315)2.24300394
49Abnormality of B cell number (HP:0010975)2.24004876
50Attenuation of retinal blood vessels (HP:0007843)2.22223779
51Widely patent fontanelles and sutures (HP:0004492)2.20854232
52B lymphocytopenia (HP:0010976)2.20132980
53Hemorrhage of the eye (HP:0011885)2.20122866
54Abnormality of the renal collecting system (HP:0004742)2.19172306
55Gonadotropin excess (HP:0000837)2.18025279
56Alveolar cell carcinoma (HP:0006519)2.17544110
57Abnormality of chromosome stability (HP:0003220)2.16217570
58Hypoproteinemia (HP:0003075)2.15482738
59Stomach cancer (HP:0012126)2.15438209
60Abnormality of pyrimidine metabolism (HP:0004353)2.10699766
61Macular degeneration (HP:0000608)2.07409502
62Ureteral duplication (HP:0000073)2.03525032
63Nephronophthisis (HP:0000090)2.01923261
64Woolly hair (HP:0002224)2.01894184
65Abnormality of the renal medulla (HP:0100957)1.99537701
66Abnormality of the prostate (HP:0008775)1.98923358
67Polar cataract (HP:0010696)1.97106644
68IgM deficiency (HP:0002850)1.94426545
69Chorioretinal atrophy (HP:0000533)1.93162506
70Neoplasm of the tracheobronchial system (HP:0100552)1.93158117
71Recurrent sinusitis (HP:0011108)1.92997167
72Retinal atrophy (HP:0001105)1.92431121
73Congenital sensorineural hearing impairment (HP:0008527)1.92076532
74Abnormality of the pons (HP:0007361)1.89978991
75Tinnitus (HP:0000360)1.87473984
76Right ventricular cardiomyopathy (HP:0011663)1.87203169
77Aplasia/Hypoplasia of the scapulae (HP:0006713)1.85846484
78Hypoplastic scapulae (HP:0000882)1.85846484
79Biliary tract neoplasm (HP:0100574)1.85627936
80Abnormal hair laboratory examination (HP:0003328)1.85616761
81Nonimmune hydrops fetalis (HP:0001790)1.85011388
82Intellectual disability, profound (HP:0002187)1.82958521
83Vascular calcification (HP:0004934)1.82385047
84Mask-like facies (HP:0000298)1.82050521
85Abnormality of the fingertips (HP:0001211)1.81636442
86Abnormal biliary tract physiology (HP:0012439)1.81226118
87Bile duct proliferation (HP:0001408)1.81226118
88Prostate neoplasm (HP:0100787)1.78954284
89Keratitis (HP:0000491)1.78577078
90Abnormality of the renal cortex (HP:0011035)1.78256496
91Spinal muscular atrophy (HP:0007269)1.77731885
92Genetic anticipation (HP:0003743)1.77636444
93Abnormality of cochlea (HP:0000375)1.77078344
94Acute lymphatic leukemia (HP:0006721)1.76870819
95Hypoplasia of the pons (HP:0012110)1.75402751
96Gout (HP:0001997)1.75298275
97Fatigue (HP:0012378)1.74049614
98Abnormality of proline metabolism (HP:0010907)1.73220480
99Hydroxyprolinuria (HP:0003080)1.73220480
100Ependymoma (HP:0002888)1.71995022

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST47.50851389
2MST1R5.53830991
3BRSK25.49761288
4WEE13.39694593
5TAOK33.30614158
6MAP4K22.68158394
7WNK42.65167079
8EPHA22.44597397
9BRSK12.35476773
10TEC2.03040781
11SIK32.01127927
12MAP3K131.89644817
13GRK11.89066853
14PINK11.88587684
15MET1.76143670
16STK101.63666062
17SIK21.54995931
18TXK1.52878268
19TRIM281.51396714
20DYRK31.42453707
21PLK41.41680388
22CAMK1D1.25739864
23ADRBK21.23469048
24NME11.08962941
25CAMK1G1.03229207
26MAP3K71.02145456
27CLK11.01429860
28IKBKB1.01258047
29TNIK0.99529598
30NEK20.98340022
31BTK0.96612067
32NLK0.95525307
33ITK0.95251168
34OXSR10.94443239
35ADRBK10.93074239
36PIK3CG0.89610945
37MARK30.83583073
38INSRR0.82653236
39STK390.77630675
40MKNK20.76562727
41BCR0.72954621
42MYLK0.70859332
43STK30.70709453
44MAP3K30.68954715
45BMX0.67019622
46NUAK10.64816334
47TLK10.63371965
48WNK10.63078976
49PRKAA20.62329826
50FRK0.61419789
51BMPR1B0.59806901
52MAPKAPK30.59543510
53PAK30.57710849
54PRKCQ0.56932282
55GRK70.54679525
56PRKAA10.52908948
57MAPK110.49069875
58TRPM70.46145083
59MOS0.45700165
60CDK80.45531864
61ROCK10.45032307
62PAK10.44923426
63TBK10.44688676
64LRRK20.44494770
65CSNK1A10.44072343
66PRKCI0.42048514
67ZAK0.38790116
68HCK0.38225628
69EPHA30.37057602
70IGF1R0.36233978
71ALK0.35126614
72EIF2AK30.34850531
73FER0.29161669
74OBSCN0.29074501
75MAPK70.28329346
76MTOR0.27893768
77CSNK1A1L0.27459056
78BMPR20.27025412
79PAK20.26431521
80STK38L0.24682933
81CDK30.24376338
82STK380.23155519
83IRAK10.23154841
84JAK20.22014137
85PRKCA0.20405028
86PLK10.20157743
87GRK50.18238314
88TGFBR20.18201144
89RIPK40.17847196
90SRPK10.17681856
91ABL10.17327588
92CASK0.17311477
93CAMK10.16922232
94MAPK10.16744321
95EGFR0.16624546
96CHUK0.14924824
97AKT10.14843951
98TTK0.14570184
99CSNK1G30.14374908
100MAPK130.13580930

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.98872728
2Caffeine metabolism_Homo sapiens_hsa002323.66342786
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.52751670
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.17282012
5Nitrogen metabolism_Homo sapiens_hsa009102.95574076
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.76577112
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.57780715
8Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.35713450
9Homologous recombination_Homo sapiens_hsa034402.32461896
10* Olfactory transduction_Homo sapiens_hsa047402.32381677
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.19970805
12Fructose and mannose metabolism_Homo sapiens_hsa000511.92134446
13RNA polymerase_Homo sapiens_hsa030201.84543964
14Asthma_Homo sapiens_hsa053101.82949363
15Graft-versus-host disease_Homo sapiens_hsa053321.81798815
16Allograft rejection_Homo sapiens_hsa053301.69846085
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.69662027
18Basal transcription factors_Homo sapiens_hsa030221.67606847
19Arginine and proline metabolism_Homo sapiens_hsa003301.66889062
20Autoimmune thyroid disease_Homo sapiens_hsa053201.60065932
21Primary immunodeficiency_Homo sapiens_hsa053401.58407959
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53553137
23Dorso-ventral axis formation_Homo sapiens_hsa043201.40431997
24Type I diabetes mellitus_Homo sapiens_hsa049401.34710949
25Salivary secretion_Homo sapiens_hsa049701.28802152
26T cell receptor signaling pathway_Homo sapiens_hsa046601.24722484
27Retinol metabolism_Homo sapiens_hsa008301.18412722
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18323905
29Circadian rhythm_Homo sapiens_hsa047101.17121676
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16962069
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.14229697
32Sulfur metabolism_Homo sapiens_hsa009201.06262579
33Protein digestion and absorption_Homo sapiens_hsa049740.99712288
34Staphylococcus aureus infection_Homo sapiens_hsa051500.97806469
35Taste transduction_Homo sapiens_hsa047420.97685335
36Purine metabolism_Homo sapiens_hsa002300.90647786
37One carbon pool by folate_Homo sapiens_hsa006700.89521718
38Glycerolipid metabolism_Homo sapiens_hsa005610.88994413
39Pancreatic secretion_Homo sapiens_hsa049720.88198316
40Sphingolipid metabolism_Homo sapiens_hsa006000.87597964
41Fanconi anemia pathway_Homo sapiens_hsa034600.86496963
42Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85839554
43Mineral absorption_Homo sapiens_hsa049780.85717224
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84193951
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84192246
46Influenza A_Homo sapiens_hsa051640.81960466
47Maturity onset diabetes of the young_Homo sapiens_hsa049500.79384990
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79288160
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.76955393
50Hematopoietic cell lineage_Homo sapiens_hsa046400.75853994
51ABC transporters_Homo sapiens_hsa020100.74987296
52Prostate cancer_Homo sapiens_hsa052150.74975516
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.74541029
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.73324419
55Non-homologous end-joining_Homo sapiens_hsa034500.73174809
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73139013
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72977886
58Propanoate metabolism_Homo sapiens_hsa006400.71733156
59Butanoate metabolism_Homo sapiens_hsa006500.70824940
60Ovarian steroidogenesis_Homo sapiens_hsa049130.70055815
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69440795
62Viral myocarditis_Homo sapiens_hsa054160.68927070
63Bile secretion_Homo sapiens_hsa049760.68149664
64RNA transport_Homo sapiens_hsa030130.67284435
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.65601692
66Antigen processing and presentation_Homo sapiens_hsa046120.64811417
67ECM-receptor interaction_Homo sapiens_hsa045120.63602128
68Measles_Homo sapiens_hsa051620.63420075
69Selenocompound metabolism_Homo sapiens_hsa004500.63201530
70Chemical carcinogenesis_Homo sapiens_hsa052040.62669323
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61849186
72Choline metabolism in cancer_Homo sapiens_hsa052310.60369632
73Herpes simplex infection_Homo sapiens_hsa051680.56874154
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56104555
75Galactose metabolism_Homo sapiens_hsa000520.56093150
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56063263
77Type II diabetes mellitus_Homo sapiens_hsa049300.51993193
78Oocyte meiosis_Homo sapiens_hsa041140.48898936
79Starch and sucrose metabolism_Homo sapiens_hsa005000.46816829
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45082776
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43860288
82Rheumatoid arthritis_Homo sapiens_hsa053230.43576276
83TNF signaling pathway_Homo sapiens_hsa046680.42420555
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.42118069
85Tyrosine metabolism_Homo sapiens_hsa003500.41980536
86Toxoplasmosis_Homo sapiens_hsa051450.41495306
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41152305
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.40035749
89Pyrimidine metabolism_Homo sapiens_hsa002400.39293950
90Linoleic acid metabolism_Homo sapiens_hsa005910.39258569
91Complement and coagulation cascades_Homo sapiens_hsa046100.38808998
92HIF-1 signaling pathway_Homo sapiens_hsa040660.37733838
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37115254
94cAMP signaling pathway_Homo sapiens_hsa040240.36393013
95B cell receptor signaling pathway_Homo sapiens_hsa046620.35667047
96Proteasome_Homo sapiens_hsa030500.35048126
97Platelet activation_Homo sapiens_hsa046110.35046827
98Acute myeloid leukemia_Homo sapiens_hsa052210.33652637
99Renal cell carcinoma_Homo sapiens_hsa052110.32532599
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.27975557

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