OR2A42

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)7.18897760
2opioid receptor signaling pathway (GO:0038003)6.98969463
3histone H3-K36 demethylation (GO:0070544)5.14248366
4cytoplasmic mRNA processing body assembly (GO:0033962)5.07975907
5regulation of posttranscriptional gene silencing (GO:0060147)4.82549881
6regulation of gene silencing by miRNA (GO:0060964)4.82549881
7regulation of gene silencing by RNA (GO:0060966)4.82549881
8organ growth (GO:0035265)4.79379394
9sperm capacitation (GO:0048240)4.70923922
10rhodopsin mediated signaling pathway (GO:0016056)4.62188926
11reproduction (GO:0000003)4.51465193
12protein-chromophore linkage (GO:0018298)4.38514660
13indole-containing compound catabolic process (GO:0042436)4.25849801
14indolalkylamine catabolic process (GO:0046218)4.25849801
15tryptophan catabolic process (GO:0006569)4.25849801
16cell wall macromolecule catabolic process (GO:0016998)4.04246590
17cell wall macromolecule metabolic process (GO:0044036)4.02759016
18cellular ketone body metabolic process (GO:0046950)3.97014677
19regulation of vacuole organization (GO:0044088)3.91277019
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.76773939
21L-fucose catabolic process (GO:0042355)3.76707400
22fucose catabolic process (GO:0019317)3.76707400
23L-fucose metabolic process (GO:0042354)3.76707400
24receptor guanylyl cyclase signaling pathway (GO:0007168)3.61262930
25prostate gland growth (GO:0060736)3.55309781
26tryptophan metabolic process (GO:0006568)3.52821743
27ketone body metabolic process (GO:1902224)3.45054023
28regulation of phospholipase A2 activity (GO:0032429)3.42722746
29regulation of autophagic vacuole assembly (GO:2000785)3.41803249
30mannose metabolic process (GO:0006013)3.39195570
31kidney morphogenesis (GO:0060993)3.36707882
32tongue development (GO:0043586)3.31603464
33somite rostral/caudal axis specification (GO:0032525)3.30474561
34negative regulation of DNA binding (GO:0043392)3.30032548
35single fertilization (GO:0007338)3.29977992
36regulation of translation, ncRNA-mediated (GO:0045974)3.28137400
37negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.28137400
38negative regulation of translation, ncRNA-mediated (GO:0040033)3.28137400
39membrane tubulation (GO:0097320)3.27062034
40positive regulation of protein kinase C signaling (GO:0090037)3.25178258
41regulation of rhodopsin mediated signaling pathway (GO:0022400)3.15596133
42histone-serine phosphorylation (GO:0035404)3.07702970
43peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.06110102
44positive regulation of Rab GTPase activity (GO:0032851)2.97192489
45regulation of Rab GTPase activity (GO:0032313)2.97192489
46regulation of keratinocyte proliferation (GO:0010837)2.95636713
47detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.93833493
48mRNA cleavage (GO:0006379)2.93392903
49lung lobe morphogenesis (GO:0060463)2.92295813
50glomerular visceral epithelial cell development (GO:0072015)2.91793373
51diacylglycerol metabolic process (GO:0046339)2.90611261
52pericardium development (GO:0060039)2.88833374
53indole-containing compound metabolic process (GO:0042430)2.81443034
54regulation of female gonad development (GO:2000194)2.81295636
55positive regulation of glycogen metabolic process (GO:0070875)2.80899234
56positive regulation of toll-like receptor signaling pathway (GO:0034123)2.79355923
57barbed-end actin filament capping (GO:0051016)2.79138026
58ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.78741387
59regulation of necroptotic process (GO:0060544)2.77749071
60negative regulation of defense response to virus (GO:0050687)2.75702662
61regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.75679559
62regulation of natural killer cell mediated immunity (GO:0002715)2.75679559
63positive regulation of vascular permeability (GO:0043117)2.75600830
64protein K63-linked deubiquitination (GO:0070536)2.74988226
65motile cilium assembly (GO:0044458)2.72789862
66primary amino compound metabolic process (GO:1901160)2.72492632
67regulation of interleukin-12 biosynthetic process (GO:0045075)2.72019559
68antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.70216395
69regulation of transforming growth factor beta2 production (GO:0032909)2.69088487
70glomerular basement membrane development (GO:0032836)2.68423974
71positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.66860942
72cell-cell recognition (GO:0009988)2.66135003
73fatty acid transmembrane transport (GO:1902001)2.64747152
74DNA double-strand break processing (GO:0000729)2.64524188
75kynurenine metabolic process (GO:0070189)2.64516468
76tachykinin receptor signaling pathway (GO:0007217)2.62959256
77negative regulation of macroautophagy (GO:0016242)2.62750622
78antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.62191895
79indolalkylamine metabolic process (GO:0006586)2.62174468
80protein targeting to vacuole (GO:0006623)2.59854585
81protein targeting to lysosome (GO:0006622)2.59854585
82establishment of protein localization to vacuole (GO:0072666)2.59854585
83sperm-egg recognition (GO:0035036)2.59835924
84activated T cell proliferation (GO:0050798)2.55231587
85serotonin metabolic process (GO:0042428)2.54944611
86endoderm formation (GO:0001706)2.54237039
87calcium ion import (GO:0070509)2.53914244
88cGMP metabolic process (GO:0046068)2.53902537
89sperm motility (GO:0030317)2.52960246
90embryonic axis specification (GO:0000578)2.52902104
91negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.50563305
92glomerular epithelial cell development (GO:0072310)2.49862464
93histone H3-K9 modification (GO:0061647)2.49811422
94hematopoietic stem cell proliferation (GO:0071425)2.48467671
95cGMP biosynthetic process (GO:0006182)2.47033428
96limb bud formation (GO:0060174)2.46683501
97regulation of acyl-CoA biosynthetic process (GO:0050812)2.45676586
98behavioral response to nicotine (GO:0035095)2.45553421
99positive regulation of male gonad development (GO:2000020)2.41349778
100phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.40353915

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.54686955
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.48192276
3GBX2_23144817_ChIP-Seq_PC3_Human3.50309252
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.11797824
5AR_21572438_ChIP-Seq_LNCaP_Human3.02010750
6ESR1_20079471_ChIP-ChIP_T-47D_Human2.78110196
7ZNF274_21170338_ChIP-Seq_K562_Hela2.73640017
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.58564724
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.37286074
10VDR_22108803_ChIP-Seq_LS180_Human2.18503017
11FUS_26573619_Chip-Seq_HEK293_Human2.14349029
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.10439289
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.04525516
14CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98365592
15RXR_22108803_ChIP-Seq_LS180_Human1.77072141
16SMAD_19615063_ChIP-ChIP_OVARY_Human1.72395599
17IGF1R_20145208_ChIP-Seq_DFB_Human1.67390648
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.67145822
19DROSHA_22980978_ChIP-Seq_HELA_Human1.64555047
20TP53_16413492_ChIP-PET_HCT116_Human1.63029151
21ER_23166858_ChIP-Seq_MCF-7_Human1.62422154
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61664724
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58666677
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58442035
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.58244891
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56457685
27SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.54398825
28P300_19829295_ChIP-Seq_ESCs_Human1.53925754
29HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.51157443
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48506859
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.46039879
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44826065
33SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44686236
34TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40135112
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40135112
36PRDM14_20953172_ChIP-Seq_ESCs_Human1.37808075
37P53_22127205_ChIP-Seq_FIBROBLAST_Human1.37789565
38RUNX2_22187159_ChIP-Seq_PCA_Human1.33960694
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33538266
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.33183692
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31376197
42CBP_20019798_ChIP-Seq_JUKART_Human1.31376197
43AR_25329375_ChIP-Seq_VCAP_Human1.31195756
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30358527
45WDR5_24793694_ChIP-Seq_LNCAP_Human1.27936840
46TCF4_23295773_ChIP-Seq_U87_Human1.27103511
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26668320
48TAF15_26573619_Chip-Seq_HEK293_Human1.25780698
49GATA3_26560356_Chip-Seq_TH2_Human1.24857194
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.22781913
51SMAD4_21799915_ChIP-Seq_A2780_Human1.18749205
52STAT3_23295773_ChIP-Seq_U87_Human1.18380091
53VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18236200
54KDM2B_26808549_Chip-Seq_REH_Human1.17148006
55AHR_22903824_ChIP-Seq_MCF-7_Human1.16234284
56EWS_26573619_Chip-Seq_HEK293_Human1.16041035
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.15270251
58OCT1_27270436_Chip-Seq_PROSTATE_Human1.14384180
59ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13267479
60KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13108457
61FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12794974
62TBL1_22424771_ChIP-Seq_293T_Human1.12407834
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12053059
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11555133
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11511010
66GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.11014958
67CDX2_22108803_ChIP-Seq_LS180_Human1.10790195
68TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.10654816
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09493721
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08877656
71IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05826368
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05522575
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04872845
74SMAD3_21741376_ChIP-Seq_HESCs_Human1.03541954
75TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.03043492
76MYB_26560356_Chip-Seq_TH2_Human1.02838785
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02339721
78ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99360903
79EZH2_27294783_Chip-Seq_NPCs_Mouse0.97750013
80TCF4_22108803_ChIP-Seq_LS180_Human0.97342907
81BCAT_22108803_ChIP-Seq_LS180_Human0.97336170
82RUNX_20019798_ChIP-Seq_JUKART_Human0.95424261
83VDR_24787735_ChIP-Seq_THP-1_Human0.94548075
84CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94394347
85GATA1_22025678_ChIP-Seq_K562_Human0.94233947
86NFYB_21822215_ChIP-Seq_K562_Human0.93388279
87CJUN_26792858_Chip-Seq_BT549_Human0.93143739
88FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92511479
89SMAD3_21741376_ChIP-Seq_EPCs_Human0.91494673
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90488720
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90366005
92ETV1_20927104_ChIP-Seq_GIST48_Human0.89198820
93PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88822232
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88507470
95NFE2_27457419_Chip-Seq_LIVER_Mouse0.88034120
96GATA3_21878914_ChIP-Seq_MCF-7_Human0.87827194
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87605616
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87299115
99CEBPB_22108803_ChIP-Seq_LS180_Human0.85561390
100SPI1_20517297_ChIP-Seq_HL60_Human0.85124805

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex6.34734138
2MP0008057_abnormal_DNA_replication6.27551750
3MP0000569_abnormal_digit_pigmentation3.75707968
4MP0003646_muscle_fatigue3.71891432
5MP0001502_abnormal_circadian_rhythm2.95852506
6MP0010368_abnormal_lymphatic_system2.77799845
7MP0002102_abnormal_ear_morphology2.68216457
8MP0003787_abnormal_imprinting2.45842552
9MP0004272_abnormal_basement_membrane2.22229836
10MP0003763_abnormal_thymus_physiology2.17204342
11MP0003890_abnormal_embryonic-extraembry2.17190709
12MP0001764_abnormal_homeostasis2.15873402
13MP0000465_gastrointestinal_hemorrhage2.06731978
14MP0005253_abnormal_eye_physiology1.84806044
15MP0003195_calcinosis1.82642281
16MP0006072_abnormal_retinal_apoptosis1.79396312
17MP0004381_abnormal_hair_follicle1.70447577
18MP0002254_reproductive_system_inflammat1.66481436
19MP0008004_abnormal_stomach_pH1.62813393
20MP0005503_abnormal_tendon_morphology1.58252596
21MP0005551_abnormal_eye_electrophysiolog1.52418424
22MP0005310_abnormal_salivary_gland1.46314484
23MP0001800_abnormal_humoral_immune1.44268647
24MP0002160_abnormal_reproductive_system1.42127534
25MP0005448_abnormal_energy_balance1.41791599
26MP0003119_abnormal_digestive_system1.40627028
27MP0002295_abnormal_pulmonary_circulatio1.39875868
28MP0002132_abnormal_respiratory_system1.32979620
29MP0005187_abnormal_penis_morphology1.31642815
30MP0003136_yellow_coat_color1.27275297
31MP0001661_extended_life_span1.26587921
32MP0001879_abnormal_lymphatic_vessel1.26539444
33MP0004084_abnormal_cardiac_muscle1.26471176
34MP0000681_abnormal_thyroid_gland1.26221670
35MP0002282_abnormal_trachea_morphology1.23124890
36MP0010386_abnormal_urinary_bladder1.19914982
37MP0008438_abnormal_cutaneous_collagen1.19758449
38MP0002933_joint_inflammation1.19265939
39MP0008961_abnormal_basal_metabolism1.18517564
40MP0001835_abnormal_antigen_presentation1.17588267
41MP0006138_congestive_heart_failure1.11171262
42MP0010030_abnormal_orbit_morphology1.09042624
43MP0003283_abnormal_digestive_organ1.04818119
44MP0005174_abnormal_tail_pigmentation1.04552626
45MP0005376_homeostasis/metabolism_phenot1.04236954
46MP0002108_abnormal_muscle_morphology1.03619623
47MP0005595_abnormal_vascular_smooth1.03489218
48MP0005671_abnormal_response_to1.03145993
49MP0004043_abnormal_pH_regulation0.99235463
50MP0005391_vision/eye_phenotype0.99147193
51MP0003385_abnormal_body_wall0.98944307
52MP0001664_abnormal_digestion0.98085507
53MP0002420_abnormal_adaptive_immunity0.96656676
54MP0002822_catalepsy0.95686961
55MP0002148_abnormal_hypersensitivity_rea0.94876400
56MP0009697_abnormal_copulation0.94027651
57MP0004264_abnormal_extraembryonic_tissu0.93852414
58MP0001819_abnormal_immune_cell0.92355813
59MP0004036_abnormal_muscle_relaxation0.91789956
60MP0000372_irregular_coat_pigmentation0.89172091
61MP0003878_abnormal_ear_physiology0.88118190
62MP0005377_hearing/vestibular/ear_phenot0.88118190
63MP0005195_abnormal_posterior_eye0.84947191
64MP0003935_abnormal_craniofacial_develop0.84862836
65MP0008995_early_reproductive_senescence0.83617394
66MP0000470_abnormal_stomach_morphology0.83210724
67MP0002452_abnormal_antigen_presenting0.83039169
68MP0004142_abnormal_muscle_tone0.81676646
69MP0002723_abnormal_immune_serum0.81074764
70MP0005389_reproductive_system_phenotype0.80826605
71MP0000383_abnormal_hair_follicle0.80732582
72MP0005275_abnormal_skin_tensile0.80532645
73MP0004130_abnormal_muscle_cell0.79743512
74MP0001849_ear_inflammation0.79118504
75MP0000230_abnormal_systemic_arterial0.78637271
76MP0002752_abnormal_somatic_nervous0.76352941
77MP0000432_abnormal_head_morphology0.73828518
78MP0005647_abnormal_sex_gland0.72152403
79MP0003936_abnormal_reproductive_system0.69903989
80MP0002876_abnormal_thyroid_physiology0.69756280
81MP0003938_abnormal_ear_development0.67648781
82MP0001299_abnormal_eye_distance/0.67345119
83MP0000716_abnormal_immune_system0.67303657
84MP0000427_abnormal_hair_cycle0.66462570
85MP0002069_abnormal_eating/drinking_beha0.66070437
86MP0000462_abnormal_digestive_system0.65310739
87MP0005266_abnormal_metabolism0.65166178
88MP0009745_abnormal_behavioral_response0.64705026
89MP0005075_abnormal_melanosome_morpholog0.64495260
90MP0009250_abnormal_appendicular_skeleto0.64255725
91MP0002115_abnormal_skeleton_extremities0.62967145
92MP0009785_altered_susceptibility_to0.62196223
93MP0002078_abnormal_glucose_homeostasis0.61782855
94MP0009333_abnormal_splenocyte_physiolog0.61467179
95MP0000703_abnormal_thymus_morphology0.60931988
96MP0001986_abnormal_taste_sensitivity0.60421524
97MP0005025_abnormal_response_to0.60177212
98MP0002398_abnormal_bone_marrow0.59796093
99MP0002233_abnormal_nose_morphology0.59611989
100MP0001756_abnormal_urination0.59103004

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.33971947
2Birth length less than 3rd percentile (HP:0003561)4.65862588
3Bilateral sensorineural hearing impairment (HP:0008619)4.43711935
4Pigmentary retinal degeneration (HP:0001146)4.41666535
5Abnormality of the columella (HP:0009929)4.18713134
6Chorioretinal atrophy (HP:0000533)3.94850548
7Abnormality of incisor morphology (HP:0011063)3.92601590
8Clumsiness (HP:0002312)3.76172827
9Ulnar claw (HP:0001178)3.73875885
10True hermaphroditism (HP:0010459)3.65229570
11Aplasia/Hypoplasia of the tongue (HP:0010295)3.62015416
12Abnormality of the incisor (HP:0000676)3.55826405
13Chronic hepatic failure (HP:0100626)3.53422907
14Pancreatic fibrosis (HP:0100732)3.52378439
15Humeroradial synostosis (HP:0003041)3.49368551
16Synostosis involving the elbow (HP:0003938)3.49368551
17Abnormal biliary tract physiology (HP:0012439)3.48978171
18Bile duct proliferation (HP:0001408)3.48978171
19Relative macrocephaly (HP:0004482)3.42629381
20Molar tooth sign on MRI (HP:0002419)3.31582565
21Abnormality of midbrain morphology (HP:0002418)3.31582565
22Pancreatic cysts (HP:0001737)3.15232476
23Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.13186958
24Sensory axonal neuropathy (HP:0003390)3.09035884
25Nasolacrimal duct obstruction (HP:0000579)2.91349979
26Hypoplasia of the uterus (HP:0000013)2.90996368
27Choanal stenosis (HP:0000452)2.90271323
28Nephronophthisis (HP:0000090)2.83416756
29Abnormality of dentin (HP:0010299)2.82909918
30Broad ribs (HP:0000885)2.76813060
31Cystic liver disease (HP:0006706)2.74303024
32Abnormality of the frontal sinuses (HP:0002687)2.70513254
33Furrowed tongue (HP:0000221)2.67449590
34Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.63455413
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.60520682
36Anencephaly (HP:0002323)2.59171704
37Genetic anticipation (HP:0003743)2.58892695
38Abnormality of the lacrimal duct (HP:0011481)2.54496079
39Anteriorly placed anus (HP:0001545)2.54018659
40Abnormality of the dental pulp (HP:0006479)2.51942624
41Broad metatarsal (HP:0001783)2.50406341
42Occipital encephalocele (HP:0002085)2.46472218
43Aortic aneurysm (HP:0004942)2.42954097
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.39601022
45Male pseudohermaphroditism (HP:0000037)2.38426286
46Absent/shortened dynein arms (HP:0200106)2.31682641
47Dynein arm defect of respiratory motile cilia (HP:0012255)2.31682641
48Intellectual disability, moderate (HP:0002342)2.30503382
49Decreased electroretinogram (ERG) amplitude (HP:0000654)2.29124762
50Protruding tongue (HP:0010808)2.28247352
51Redundant skin (HP:0001582)2.25218685
52Microglossia (HP:0000171)2.24596380
53Increased neuronal autofluorescent lipopigment (HP:0002074)2.22926090
54Squamous cell carcinoma (HP:0002860)2.22861250
55Hypoplasia of the maxilla (HP:0000327)2.22729145
56Global brain atrophy (HP:0002283)2.20725445
57Abnormality of the nasolacrimal system (HP:0000614)2.20505169
58Pendular nystagmus (HP:0012043)2.17992421
59Conical tooth (HP:0000698)2.17861963
60Abnormal ciliary motility (HP:0012262)2.16929442
61Segmental peripheral demyelination/remyelination (HP:0003481)2.16533712
62Breast hypoplasia (HP:0003187)2.16484260
63Abnormality of the renal medulla (HP:0100957)2.15029893
64Premature skin wrinkling (HP:0100678)2.14109925
65Abnormal rod and cone electroretinograms (HP:0008323)2.13373961
66Epiphyseal dysplasia (HP:0002656)2.12682582
67Thyroiditis (HP:0100646)2.11914369
68Tinnitus (HP:0000360)2.11194606
69Progressive cerebellar ataxia (HP:0002073)2.10285660
70Mesangial abnormality (HP:0001966)2.10098401
71Decreased circulating renin level (HP:0003351)2.05090064
72Abnormal respiratory epithelium morphology (HP:0012253)2.04179182
73Abnormal respiratory motile cilium morphology (HP:0005938)2.04179182
74Tracheomalacia (HP:0002779)2.02800486
75Hypoplastic labia majora (HP:0000059)2.02332416
76Abnormality of the labia majora (HP:0012881)1.98196797
77Symphalangism affecting the phalanges of the hand (HP:0009773)1.95695067
78Stomatitis (HP:0010280)1.94141360
79Abnormality of T cell number (HP:0011839)1.93078619
80Metaphyseal dysplasia (HP:0100255)1.91468923
81Patellar aplasia (HP:0006443)1.91187069
82Knee flexion contracture (HP:0006380)1.90764983
83Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.89657168
84Panhypogammaglobulinemia (HP:0003139)1.89592396
85T lymphocytopenia (HP:0005403)1.89428999
86Hypoplastic ischia (HP:0003175)1.88761215
87Macular degeneration (HP:0000608)1.87388080
88Abnormality of the ischium (HP:0003174)1.87263647
89Cupped ear (HP:0000378)1.85913056
90Oculomotor apraxia (HP:0000657)1.84919636
91Preaxial foot polydactyly (HP:0001841)1.83424750
92Aplasia/hypoplasia of the uterus (HP:0008684)1.83154711
93Hypoproteinemia (HP:0003075)1.82902718
94Vitreoretinal degeneration (HP:0000655)1.82726657
95Aplasia cutis congenita (HP:0001057)1.80828558
96Scrotal hypoplasia (HP:0000046)1.78285842
97Recurrent bronchitis (HP:0002837)1.75681514
98Craniofacial hyperostosis (HP:0004493)1.74840782
99Supernumerary spleens (HP:0009799)1.74743868
100Hematochezia (HP:0002573)1.74268760

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B4.97380078
2BMPR1B4.18759406
3FRK3.78608608
4MARK33.67352798
5BRSK23.16275227
6CAMKK22.85197890
7NEK22.80205977
8FGFR22.78231837
9TGFBR12.53120554
10SIK22.19106150
11STK38L1.99800099
12SIK31.99650399
13TIE11.93085112
14MELK1.83760825
15BTK1.76263401
16WNK31.69383747
17TLK11.69195265
18PINK11.69189228
19LATS11.60317729
20MYLK1.59067407
21SIK11.57491694
22BLK1.57283595
23NLK1.55578064
24MST1R1.54771416
25TNIK1.53763888
26ADRBK21.44651830
27AKT31.41031273
28STK381.30955185
29MAP3K131.28240830
30TEC1.27050139
31ITK1.21778275
32CAMKK11.18850295
33PRKCQ1.18806918
34ZAK1.14266900
35JAK31.11869541
36MAPK151.10374130
37SGK4941.09099494
38SGK2231.09099494
39ICK1.06651887
40MARK21.04609845
41SGK21.02305435
42FGR1.01089489
43TNK20.97487104
44GRK10.94280385
45PRKG20.91934341
46CHUK0.88848600
47ADRBK10.80163054
48MAP4K10.78949020
49PIM10.76274759
50MAP2K10.72899329
51CDK30.71060728
52TXK0.70278200
53CAMK1D0.68711119
54MET0.68679222
55CDK190.64912556
56CSNK1A1L0.63562183
57CDC42BPA0.62696012
58OBSCN0.62646883
59RPS6KB20.61823471
60IKBKB0.56326344
61PRKAA10.52916870
62OXSR10.52556160
63CDK120.52240461
64TGFBR20.50192626
65EGFR0.49778888
66RPS6KB10.49688197
67PDGFRB0.49411382
68PTK2B0.48750766
69CASK0.48708159
70LCK0.47796392
71MAP4K20.46434118
72MAP3K90.44910148
73MAPKAPK30.43315243
74DYRK30.41649304
75BMX0.39979469
76KIT0.39671189
77ERBB20.38803579
78CSNK1G10.38395565
79CSNK1G30.37379340
80IKBKE0.36557713
81MAP3K20.35998707
82CSNK1D0.35004860
83JAK10.34376177
84SYK0.33753702
85BRSK10.33702271
86PAK20.32974201
87RPS6KA50.32132937
88MAP2K70.30766783
89MAPK120.30593606
90LYN0.29990770
91PRKAA20.29550497
92CAMK10.28900822
93MAP3K100.28586151
94WNK10.28482980
95SGK30.27448003
96GRK60.27342912
97STK110.27027301
98PKN10.23606156
99FGFR30.23000517
100CAMK40.22972068

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.84715701
2* Olfactory transduction_Homo sapiens_hsa047402.62624935
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.51214258
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.38599062
5Linoleic acid metabolism_Homo sapiens_hsa005912.23592834
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.18389124
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.17395099
8Circadian rhythm_Homo sapiens_hsa047101.86908772
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.71847809
10Nitrogen metabolism_Homo sapiens_hsa009101.68401234
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.63021181
12Primary immunodeficiency_Homo sapiens_hsa053401.54968622
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54626527
14Butanoate metabolism_Homo sapiens_hsa006501.51814484
15Vascular smooth muscle contraction_Homo sapiens_hsa042701.50843078
16ABC transporters_Homo sapiens_hsa020101.48528925
17Hedgehog signaling pathway_Homo sapiens_hsa043401.45694011
18Selenocompound metabolism_Homo sapiens_hsa004501.43609088
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39680386
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.35477998
21Fatty acid biosynthesis_Homo sapiens_hsa000611.34609363
22Caffeine metabolism_Homo sapiens_hsa002321.31790091
23Taste transduction_Homo sapiens_hsa047421.31303954
24Chemical carcinogenesis_Homo sapiens_hsa052041.30193112
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29381346
26Malaria_Homo sapiens_hsa051441.29111302
27RNA polymerase_Homo sapiens_hsa030201.26633347
28ECM-receptor interaction_Homo sapiens_hsa045121.20287588
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.17012900
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16794070
31Arachidonic acid metabolism_Homo sapiens_hsa005901.11683380
32FoxO signaling pathway_Homo sapiens_hsa040681.11009088
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04503402
34Small cell lung cancer_Homo sapiens_hsa052221.03067488
35Retinol metabolism_Homo sapiens_hsa008300.99416721
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99289120
37Lysine degradation_Homo sapiens_hsa003100.98478384
38Ether lipid metabolism_Homo sapiens_hsa005650.97223524
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95931842
40One carbon pool by folate_Homo sapiens_hsa006700.95055363
41Basal cell carcinoma_Homo sapiens_hsa052170.94053887
42Morphine addiction_Homo sapiens_hsa050320.93355283
43Tryptophan metabolism_Homo sapiens_hsa003800.91171386
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91131672
45Allograft rejection_Homo sapiens_hsa053300.89976035
46Calcium signaling pathway_Homo sapiens_hsa040200.89272809
47Herpes simplex infection_Homo sapiens_hsa051680.85508711
48T cell receptor signaling pathway_Homo sapiens_hsa046600.77523817
49Graft-versus-host disease_Homo sapiens_hsa053320.77454571
50Glycerophospholipid metabolism_Homo sapiens_hsa005640.75718623
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75705791
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74828157
53RNA degradation_Homo sapiens_hsa030180.74059169
54Autoimmune thyroid disease_Homo sapiens_hsa053200.73651501
55Ras signaling pathway_Homo sapiens_hsa040140.71911212
56Hippo signaling pathway_Homo sapiens_hsa043900.71041681
57Circadian entrainment_Homo sapiens_hsa047130.70841125
58Other glycan degradation_Homo sapiens_hsa005110.70694438
59Oxytocin signaling pathway_Homo sapiens_hsa049210.70301398
60Measles_Homo sapiens_hsa051620.68556128
61Systemic lupus erythematosus_Homo sapiens_hsa053220.68204727
62Insulin resistance_Homo sapiens_hsa049310.66615813
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65777698
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64054280
65Hematopoietic cell lineage_Homo sapiens_hsa046400.63942539
66Type I diabetes mellitus_Homo sapiens_hsa049400.63713828
67Chemokine signaling pathway_Homo sapiens_hsa040620.63417930
68Ovarian steroidogenesis_Homo sapiens_hsa049130.63133604
69Staphylococcus aureus infection_Homo sapiens_hsa051500.61346135
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61288301
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60772739
72Basal transcription factors_Homo sapiens_hsa030220.59856399
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.58808856
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56757581
75Pathways in cancer_Homo sapiens_hsa052000.56337523
76Peroxisome_Homo sapiens_hsa041460.56284495
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56004356
78Platelet activation_Homo sapiens_hsa046110.55929230
79p53 signaling pathway_Homo sapiens_hsa041150.54137500
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53893484
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53430964
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53285472
83Axon guidance_Homo sapiens_hsa043600.50598277
84Gastric acid secretion_Homo sapiens_hsa049710.50329002
85Glutamatergic synapse_Homo sapiens_hsa047240.50124946
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49727171
87Focal adhesion_Homo sapiens_hsa045100.49190144
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49058645
89B cell receptor signaling pathway_Homo sapiens_hsa046620.45562105
90Renin secretion_Homo sapiens_hsa049240.44965991
91Thyroid cancer_Homo sapiens_hsa052160.44712197
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43881651
93Wnt signaling pathway_Homo sapiens_hsa043100.43765501
94beta-Alanine metabolism_Homo sapiens_hsa004100.41914878
95TGF-beta signaling pathway_Homo sapiens_hsa043500.40874658
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37702536
97Protein digestion and absorption_Homo sapiens_hsa049740.37201428
98Dorso-ventral axis formation_Homo sapiens_hsa043200.36826295
99Glucagon signaling pathway_Homo sapiens_hsa049220.36379219
100Prostate cancer_Homo sapiens_hsa052150.35531627

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