OR2A7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of guanylate cyclase activity (GO:0031284)5.50991877
2regulation of guanylate cyclase activity (GO:0031282)5.33335448
3kynurenine metabolic process (GO:0070189)4.78625542
4glyoxylate metabolic process (GO:0046487)4.78260100
5indole-containing compound catabolic process (GO:0042436)4.73254578
6indolalkylamine catabolic process (GO:0046218)4.73254578
7tryptophan catabolic process (GO:0006569)4.73254578
8heparin biosynthetic process (GO:0030210)4.53051246
9heparin metabolic process (GO:0030202)4.53051246
10ER overload response (GO:0006983)4.46927842
11protein targeting to Golgi (GO:0000042)4.16693606
12sphingoid metabolic process (GO:0046519)4.15889293
13histone H3-K4 trimethylation (GO:0080182)4.13842394
14bundle of His cell to Purkinje myocyte communication (GO:0086069)4.11043404
15endothelial cell morphogenesis (GO:0001886)4.09506663
16sphingosine metabolic process (GO:0006670)4.06822839
17establishment of protein localization to Golgi (GO:0072600)4.06232280
18nephron tubule formation (GO:0072079)3.97879901
19retrograde transport, vesicle recycling within Golgi (GO:0000301)3.84550741
20aldehyde catabolic process (GO:0046185)3.73532925
21diol metabolic process (GO:0034311)3.65199993
22regulation of transforming growth factor beta2 production (GO:0032909)3.63409039
23negative regulation of metanephros development (GO:0072217)3.62854827
24tryptophan metabolic process (GO:0006568)3.57767025
25regulation of water loss via skin (GO:0033561)3.46498056
26desmosome organization (GO:0002934)3.42374192
27negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.41535127
28indolalkylamine metabolic process (GO:0006586)3.40984198
29multicellular organism reproduction (GO:0032504)3.40448361
30aromatic amino acid family catabolic process (GO:0009074)3.39458087
31regulation of cGMP biosynthetic process (GO:0030826)3.36688088
32positive regulation of cGMP biosynthetic process (GO:0030828)3.36553275
33NAD biosynthetic process (GO:0009435)3.35890788
34maintenance of gastrointestinal epithelium (GO:0030277)3.28290522
35establishment of skin barrier (GO:0061436)3.22099544
36auditory receptor cell differentiation (GO:0042491)3.18168694
37lactate metabolic process (GO:0006089)3.17312024
38negative regulation of T cell differentiation in thymus (GO:0033085)3.16805799
39keratinocyte development (GO:0003334)3.16067762
40regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.14499203
41protein-chromophore linkage (GO:0018298)3.03226285
42O-glycan processing (GO:0016266)3.02916633
43macroautophagy (GO:0016236)2.97554314
44cellular biogenic amine catabolic process (GO:0042402)2.96606570
45amine catabolic process (GO:0009310)2.96606570
46pyridine nucleotide biosynthetic process (GO:0019363)2.92217489
47nicotinamide nucleotide biosynthetic process (GO:0019359)2.92217489
48cellular ketone body metabolic process (GO:0046950)2.90288978
49protein localization to Golgi apparatus (GO:0034067)2.89916059
50oxidative demethylation (GO:0070989)2.89392457
51regulation of bile acid biosynthetic process (GO:0070857)2.89212153
52nephron tubule morphogenesis (GO:0072078)2.85293425
53nephron epithelium morphogenesis (GO:0072088)2.85293425
54regulation of mesenchymal cell apoptotic process (GO:2001053)2.85031055
55platelet dense granule organization (GO:0060155)2.82564085
56multicellular organismal water homeostasis (GO:0050891)2.82269245
57positive regulation of digestive system process (GO:0060456)2.80316445
58cellular glucuronidation (GO:0052695)2.79883950
59sphingomyelin metabolic process (GO:0006684)2.78186472
60regulation of cGMP metabolic process (GO:0030823)2.77001933
61response to growth hormone (GO:0060416)2.75946891
62positive regulation of cGMP metabolic process (GO:0030825)2.73260750
63regulation of glucokinase activity (GO:0033131)2.73078947
64regulation of hexokinase activity (GO:1903299)2.73078947
65uronic acid metabolic process (GO:0006063)2.72365104
66glucuronate metabolic process (GO:0019585)2.72365104
67regulation of keratinocyte proliferation (GO:0010837)2.71654825
68negative regulation of myotube differentiation (GO:0010832)2.68053729
69regulation of apoptotic process involved in morphogenesis (GO:1902337)2.66512133
70protein localization to cell surface (GO:0034394)2.66260100
71indole-containing compound metabolic process (GO:0042430)2.62827298
72reproduction (GO:0000003)2.62452338
73phosphate ion transmembrane transport (GO:0035435)2.61763174
74negative regulation of keratinocyte proliferation (GO:0010839)2.60932137
75ketone body metabolic process (GO:1902224)2.60845874
76nephron tubule development (GO:0072080)2.60460479
77keratinization (GO:0031424)2.59697360
78phosphate ion transport (GO:0006817)2.58828807
79pyridine-containing compound biosynthetic process (GO:0072525)2.58622803
80regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.57046657
81negative regulation of glycogen biosynthetic process (GO:0045719)2.55087205
82regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.54922048
83positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.54433642
84transepithelial transport (GO:0070633)2.51634655
85skin morphogenesis (GO:0043589)2.50548429
86coenzyme catabolic process (GO:0009109)2.48660184
87negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.47908271
88L-methionine salvage (GO:0071267)2.47361263
89L-methionine biosynthetic process (GO:0071265)2.47361263
90amino acid salvage (GO:0043102)2.47361263
91histone H3-K4 methylation (GO:0051568)2.46414534
92brain morphogenesis (GO:0048854)2.46013194
93negative regulation of glycogen metabolic process (GO:0070874)2.43536954
94renal tubule development (GO:0061326)2.43286907
95aromatic amino acid family metabolic process (GO:0009072)2.43032147
96cochlea development (GO:0090102)2.42163204
97regulation of type B pancreatic cell apoptotic process (GO:2000674)2.42071641
98growth hormone receptor signaling pathway (GO:0060396)2.42001618
99intra-Golgi vesicle-mediated transport (GO:0006891)2.39745225
100nucleotide transmembrane transport (GO:1901679)2.39314062

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD_19615063_ChIP-ChIP_OVARY_Human4.03930570
2ESR1_20079471_ChIP-ChIP_T-47D_Human2.83493018
3ZNF217_24962896_ChIP-Seq_MCF-7_Human2.64676961
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.57836593
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.40843352
6CJUN_26792858_Chip-Seq_BT549_Human2.17362887
7CDX2_20551321_ChIP-Seq_CACO-2_Human2.11031612
8AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.02918394
9ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.02896679
10ARNT_22903824_ChIP-Seq_MCF-7_Human1.99548964
11HIF1A_21447827_ChIP-Seq_MCF-7_Human1.99322459
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.98929236
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89192060
14AHR_22903824_ChIP-Seq_MCF-7_Human1.87318660
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.86889204
16ESR2_21235772_ChIP-Seq_MCF-7_Human1.86008386
17FOXM1_26456572_ChIP-Seq_MCF-7_Human1.79219986
18FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.78591370
19GBX2_23144817_ChIP-Seq_PC3_Human1.78367138
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77416967
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.75607894
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.71660640
23VDR_22108803_ChIP-Seq_LS180_Human1.70793544
24PPAR_26484153_Chip-Seq_NCI-H1993_Human1.67016953
25CDX2_22108803_ChIP-Seq_LS180_Human1.62685808
26GATA4_25053715_ChIP-Seq_YYC3_Human1.61067663
27TP63_23658742_ChIP-Seq_EP156T_Human1.59586376
28CBP_20019798_ChIP-Seq_JUKART_Human1.58792617
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58792617
30TP53_18474530_ChIP-ChIP_U2OS_Human1.57804471
31NR3C1_21868756_ChIP-Seq_MCF10A_Human1.53815805
32GATA6_25053715_ChIP-Seq_YYC3_Human1.51241205
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49376659
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48036154
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.47618667
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47216816
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.46865176
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46392974
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45735150
40TCF4_22108803_ChIP-Seq_LS180_Human1.44415366
41SOX2_20726797_ChIP-Seq_SW620_Human1.41754994
42SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.38230833
43SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.38230833
44AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.37503767
45LXR_22158963_ChIP-Seq_LIVER_Mouse1.37230687
46CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33836515
47SMAD4_21799915_ChIP-Seq_A2780_Human1.33743130
48ER_23166858_ChIP-Seq_MCF-7_Human1.32275129
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.32093379
50FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.31591855
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.30449130
52TCF4_23295773_ChIP-Seq_U87_Human1.28912897
53JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28883446
54BCAT_22108803_ChIP-Seq_LS180_Human1.27108833
55SOX2_27498859_Chip-Seq_STOMACH_Mouse1.26547041
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25454655
57GATA3_24758297_ChIP-Seq_MCF-7_Human1.22632892
58HNFA_21074721_ChIP-Seq_CACO-2_Human1.21974867
59IRF8_22096565_ChIP-ChIP_GC-B_Human1.21755871
60SMAD3_21741376_ChIP-Seq_HESCs_Human1.21663392
61FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.21172543
62FUS_26573619_Chip-Seq_HEK293_Human1.20380110
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19453344
64FOXA2_19822575_ChIP-Seq_HepG2_Human1.19262503
65CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.18465592
66* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18173017
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17606329
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17385461
69RXR_22108803_ChIP-Seq_LS180_Human1.16397787
70STAT3_23295773_ChIP-Seq_U87_Human1.15816045
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15493755
72* HOXB7_26014856_ChIP-Seq_BT474_Human1.15184752
73P63_26484246_Chip-Seq_KERATINOCYTES_Human1.14713545
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13822114
75PHF8_20622853_ChIP-Seq_HELA_Human1.13483122
76RUNX1_27514584_Chip-Seq_MCF-7_Human1.08483596
77ZNF274_21170338_ChIP-Seq_K562_Hela1.07470132
78SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06613254
79AR_25329375_ChIP-Seq_VCAP_Human1.06201562
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06089766
81KLF5_25053715_ChIP-Seq_YYC3_Human1.04530822
82TBL1_22424771_ChIP-Seq_293T_Human1.01821455
83SMAD4_21741376_ChIP-Seq_HESCs_Human1.01769940
84GATA6_21074721_ChIP-Seq_CACO-2_Human1.01476431
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00947546
86GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00254997
87JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99606307
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99413689
89TCF4_18268006_ChIP-ChIP_LS174T_Human0.98520571
90NFYB_21822215_ChIP-Seq_K562_Human0.97978573
91P300_19829295_ChIP-Seq_ESCs_Human0.97732553
92TP53_16413492_ChIP-PET_HCT116_Human0.97588724
93SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97565690
94RXR_22158963_ChIP-Seq_LIVER_Mouse0.97156782
95EP300_21415370_ChIP-Seq_HL-1_Mouse0.95933063
96FOXA1_25552417_ChIP-Seq_VCAP_Human0.95737224
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95347154
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95292018
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94967589
100CEBPB_22108803_ChIP-Seq_LS180_Human0.91237163

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.22657139
2MP0008875_abnormal_xenobiotic_pharmacok3.96143784
3MP0002138_abnormal_hepatobiliary_system3.95321681
4MP0010234_abnormal_vibrissa_follicle3.83315042
5MP0003195_calcinosis3.62917232
6MP0005503_abnormal_tendon_morphology3.42895916
7MP0003252_abnormal_bile_duct3.27436307
8MP0009780_abnormal_chondrocyte_physiolo2.76900070
9MP0010678_abnormal_skin_adnexa2.52886070
10MP0001666_abnormal_nutrient_absorption2.40519671
11MP0005085_abnormal_gallbladder_physiolo2.28679125
12MP0010386_abnormal_urinary_bladder2.28245313
13MP0003950_abnormal_plasma_membrane2.27575691
14MP0000427_abnormal_hair_cycle2.22814623
15MP0002254_reproductive_system_inflammat2.19993066
16MP0002796_impaired_skin_barrier2.04529546
17MP0000538_abnormal_urinary_bladder1.95336650
18MP0010352_gastrointestinal_tract_polyps1.91218487
19MP0001501_abnormal_sleep_pattern1.90358243
20MP0010329_abnormal_lipoprotein_level1.87830929
21MP0004264_abnormal_extraembryonic_tissu1.79188935
22MP0003183_abnormal_peptide_metabolism1.77567880
23MP0002928_abnormal_bile_duct1.68622334
24MP0004272_abnormal_basement_membrane1.67415378
25MP0005257_abnormal_intraocular_pressure1.63868752
26MP0004019_abnormal_vitamin_homeostasis1.59644648
27MP0005275_abnormal_skin_tensile1.50902367
28MP0001873_stomach_inflammation1.49725582
29MP0005365_abnormal_bile_salt1.49648903
30MP0005083_abnormal_biliary_tract1.48542388
31MP0004381_abnormal_hair_follicle1.47950614
32MP0000015_abnormal_ear_pigmentation1.47858102
33MP0001765_abnormal_ion_homeostasis1.44783649
34MP0005174_abnormal_tail_pigmentation1.43024795
35MP0000762_abnormal_tongue_morphology1.42071030
36MP0001348_abnormal_lacrimal_gland1.36803889
37MP0005023_abnormal_wound_healing1.32880101
38MP0000003_abnormal_adipose_tissue1.27833118
39MP0005360_urolithiasis1.27553516
40MP0001664_abnormal_digestion1.26197993
41MP0005409_darkened_coat_color1.23890626
42MP0009643_abnormal_urine_homeostasis1.22446541
43MP0002060_abnormal_skin_morphology1.19041692
44MP0005551_abnormal_eye_electrophysiolog1.15268826
45MP0003868_abnormal_feces_composition1.14279185
46MP0001851_eye_inflammation1.14084039
47MP0000647_abnormal_sebaceous_gland1.14063946
48MP0009697_abnormal_copulation1.13965643
49MP0001216_abnormal_epidermal_layer1.13672751
50MP0001756_abnormal_urination1.13020486
51MP0004134_abnormal_chest_morphology1.12103586
52MP0005164_abnormal_response_to1.11493562
53MP0002136_abnormal_kidney_physiology1.10486762
54MP0003878_abnormal_ear_physiology1.09672659
55MP0005377_hearing/vestibular/ear_phenot1.09672659
56MP0006054_spinal_hemorrhage1.09035583
57MP0009115_abnormal_fat_cell1.06226640
58MP0005410_abnormal_fertilization1.06216482
59MP0008004_abnormal_stomach_pH1.01860631
60MP0001270_distended_abdomen1.00317296
61MP0002108_abnormal_muscle_morphology1.00286111
62MP0005408_hypopigmentation0.99675350
63MP0002896_abnormal_bone_mineralization0.96905664
64MP0010155_abnormal_intestine_physiology0.96392754
65MP0004043_abnormal_pH_regulation0.94506108
66MP0000383_abnormal_hair_follicle0.90994640
67MP0001485_abnormal_pinna_reflex0.90406225
68MP0002118_abnormal_lipid_homeostasis0.89539838
69MP0002166_altered_tumor_susceptibility0.89112252
70MP0005332_abnormal_amino_acid0.88508461
71MP0002115_abnormal_skeleton_extremities0.86996660
72MP0000377_abnormal_hair_follicle0.83442608
73MP0009840_abnormal_foam_cell0.82218673
74MP0005448_abnormal_energy_balance0.81246664
75MP0006082_CNS_inflammation0.80717039
76MP0003763_abnormal_thymus_physiology0.79048990
77MP0009384_cardiac_valve_regurgitation0.77867021
78MP0005508_abnormal_skeleton_morphology0.77163035
79MP0000470_abnormal_stomach_morphology0.77098694
80MP0005670_abnormal_white_adipose0.76460877
81MP0010771_integument_phenotype0.76111072
82MP0000230_abnormal_systemic_arterial0.76052759
83MP0004782_abnormal_surfactant_physiolog0.75848426
84MP0003943_abnormal_hepatobiliary_system0.74583465
85MP0000367_abnormal_coat/_hair0.71485240
86MP0003566_abnormal_cell_adhesion0.70249978
87MP0004085_abnormal_heartbeat0.70236216
88MP0002693_abnormal_pancreas_physiology0.69635539
89MP0001502_abnormal_circadian_rhythm0.68167516
90MP0004484_altered_response_of0.67782081
91MP0003866_abnormal_defecation0.66990367
92MP0005636_abnormal_mineral_homeostasis0.66591671
93MP0003941_abnormal_skin_development0.64844669
94MP0009785_altered_susceptibility_to0.64261872
95MP0003191_abnormal_cellular_cholesterol0.63629167
96MP0000371_diluted_coat_color0.62139813
97MP0005647_abnormal_sex_gland0.61662364
98MP0002876_abnormal_thyroid_physiology0.61410619
99MP0000613_abnormal_salivary_gland0.61232582
100MP0002098_abnormal_vibrissa_morphology0.60846359

Predicted human phenotypes

RankGene SetZ-score
1Glucose intolerance (HP:0000833)5.04259171
2Abnormal pancreas size (HP:0012094)4.76020105
3Hypoplasia of the uterus (HP:0000013)4.10723193
4Abnormal glucose tolerance (HP:0001952)3.99325210
5Malnutrition (HP:0004395)3.90547660
6Abnormality of the nasal septum (HP:0000419)3.65048976
7Hyperkalemia (HP:0002153)3.64367826
8Abnormal tarsal ossification (HP:0008369)3.53769656
9Gout (HP:0001997)3.52790906
10Tetraparesis (HP:0002273)3.51838285
11Abnormality of proline metabolism (HP:0010907)3.46714974
12Hydroxyprolinuria (HP:0003080)3.46714974
13Hyperactive renin-angiotensin system (HP:0000841)3.43122659
14Right ventricular cardiomyopathy (HP:0011663)3.26968225
15Lip pit (HP:0100267)3.18370696
16Decreased circulating renin level (HP:0003351)3.07061998
17Shawl scrotum (HP:0000049)3.00664266
18Abnormality of macular pigmentation (HP:0008002)2.94592121
19Hypophosphatemic rickets (HP:0004912)2.93373477
20Congenital sensorineural hearing impairment (HP:0008527)2.91722154
21Abnormality of chloride homeostasis (HP:0011422)2.83148019
22Late onset (HP:0003584)2.62859086
23Tubular atrophy (HP:0000092)2.61647588
24Abnormality of the fingertips (HP:0001211)2.61611375
25Aplasia/hypoplasia of the uterus (HP:0008684)2.61314766
26Abnormal foot bone ossification (HP:0010675)2.60869259
27Dyschromatopsia (HP:0007641)2.59753126
28Abnormality of glutamine family amino acid metabolism (HP:0010902)2.59498010
29Severe visual impairment (HP:0001141)2.55325392
30Tubulointerstitial fibrosis (HP:0005576)2.52533853
31Hyperaldosteronism (HP:0000859)2.50939536
32Chronic bronchitis (HP:0004469)2.47072063
33Abnormality of renin-angiotensin system (HP:0000847)2.45146865
34Abnormality of incisor morphology (HP:0011063)2.41917954
35Posterior subcapsular cataract (HP:0007787)2.33310545
36Alopecia of scalp (HP:0002293)2.31774976
37Abnormality of calcium-phosphate metabolism (HP:0100530)2.30322204
38Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.28690592
39Enlarged epiphyses (HP:0010580)2.28165668
40Exocrine pancreatic insufficiency (HP:0001738)2.28051559
41Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.27405799
42Subcapsular cataract (HP:0000523)2.24495410
43Mitral stenosis (HP:0001718)2.22382749
44Attenuation of retinal blood vessels (HP:0007843)2.20636944
45Albinism (HP:0001022)2.19335890
46Tubulointerstitial nephritis (HP:0001970)2.16961988
47Tubulointerstitial abnormality (HP:0001969)2.15989542
48Villous atrophy (HP:0011473)2.13523722
49Abnormality of small intestinal villus morphology (HP:0011472)2.13523722
50Vascular calcification (HP:0004934)2.11519172
51Chorioretinal atrophy (HP:0000533)2.11429189
52Macular degeneration (HP:0000608)2.08185282
53Unilateral renal agenesis (HP:0000122)2.05635303
54Broad face (HP:0000283)2.04988425
55Decreased central vision (HP:0007663)2.04695033
56Tibial bowing (HP:0002982)2.04095526
57Woolly hair (HP:0002224)2.02839721
58Focal segmental glomerulosclerosis (HP:0000097)2.02520496
59Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.01816925
60Abnormality of potassium homeostasis (HP:0011042)2.01402560
61Osteomalacia (HP:0002749)1.99962967
62Dehydration (HP:0001944)1.97991382
63Chronic diarrhea (HP:0002028)1.97071701
64Abnormal hair laboratory examination (HP:0003328)1.95176291
65Palmar hyperkeratosis (HP:0010765)1.95070118
66Cone-rod dystrophy (HP:0000548)1.91935077
67Abnormality of the aortic arch (HP:0012303)1.91169199
68Plantar hyperkeratosis (HP:0007556)1.90139947
69Abnormality of vitamin metabolism (HP:0100508)1.86555137
70Metabolic alkalosis (HP:0200114)1.85618056
71Hypoplasia of dental enamel (HP:0006297)1.85614742
72Ileus (HP:0002595)1.85232081
73Cardiovascular calcification (HP:0011915)1.84550159
74Glomerulosclerosis (HP:0000096)1.82675584
75Bilateral sensorineural hearing impairment (HP:0008619)1.81347209
76Onycholysis (HP:0001806)1.81061852
77Milia (HP:0001056)1.80063197
78Hamartoma of the eye (HP:0010568)1.79956475
79Hemorrhage of the eye (HP:0011885)1.79601180
80Palmoplantar hyperkeratosis (HP:0000972)1.79424383
81Abnormality of the epiphyses of the hand (HP:0005924)1.79220275
82Hypoplastic labia majora (HP:0000059)1.79205440
83Oligodontia (HP:0000677)1.77063373
84Bronchitis (HP:0012387)1.76880599
85Increased CSF protein (HP:0002922)1.76547938
86Atrophic scars (HP:0001075)1.75133676
87Hypoplasia of the odontoid process (HP:0003311)1.74349540
88Sensory axonal neuropathy (HP:0003390)1.73755720
89Bronchomalacia (HP:0002780)1.73271306
90Rickets (HP:0002748)1.71924459
91Neonatal short-limb short stature (HP:0008921)1.71334272
92Abnormality of the labia majora (HP:0012881)1.71303603
93Popliteal pterygium (HP:0009756)1.71050956
94Pancreatic cysts (HP:0001737)1.70908616
95Pili torti (HP:0003777)1.70717642
96Hyponatremia (HP:0002902)1.69948606
97Stage 5 chronic kidney disease (HP:0003774)1.69558479
98Polar cataract (HP:0010696)1.69244872
99Abnormality of vitamin B metabolism (HP:0004340)1.68234344
100Increased purine levels (HP:0004368)1.67891321

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.35027339
2FRK5.16795940
3MST44.72512288
4EIF2AK33.91868625
5ACVR1B3.65590513
6MET3.63019631
7EPHA23.26854577
8NEK62.04809649
9PIK3CA1.97250498
10RIPK11.94199348
11WNK41.88140374
12MAP4K21.79777386
13STK391.69752289
14TNIK1.68196084
15STK38L1.64373390
16FER1.42852680
17BMX1.26342170
18FGFR21.26025468
19LMTK21.23043832
20TRPM71.22059847
21GRK11.19982139
22BMPR1B1.12437394
23PDGFRB1.09983971
24NLK1.09964243
25PDK21.03401230
26SIK31.01526227
27PRKCI1.01074195
28PAK30.97627855
29OXSR10.94604702
30MAPK150.94597635
31WNK10.92594570
32MAP3K20.90784106
33TRIM280.90760888
34CDK80.90736457
35STK380.89454718
36PRKCE0.87523008
37EPHA30.86717102
38MAP3K70.84982221
39PINK10.84505979
40MAP3K30.83623179
41CAMK1D0.82956722
42MKNK20.81324791
43FGFR30.78800219
44BRSK20.76007081
45TGFBR10.75277893
46CHUK0.73620401
47PRKD30.70245398
48PRKAA20.70199256
49EIF2AK10.67564576
50PDPK10.67261116
51MYLK0.67259218
52PDK10.65932683
53ERBB30.61892077
54CAMK1G0.61479053
55PTK20.61298479
56INSRR0.59553223
57CDK120.57585224
58TGFBR20.55588468
59DDR20.55288326
60JAK10.55151922
61BCR0.53943710
62PTK2B0.51350730
63MAP2K60.50967137
64PBK0.49978571
65ERBB20.48979055
66RAF10.48719398
67ROCK10.48580497
68RET0.48411347
69NUAK10.48088470
70IRAK10.47993116
71KSR10.47841180
72EPHB10.46968118
73TBK10.46716014
74MAP2K10.46693162
75FGFR10.46410058
76FGFR40.46036555
77STK100.42273540
78PRKG20.41975777
79STK30.41065574
80ADRBK10.40102707
81EPHA40.39641346
82ABL10.39219218
83MELK0.38849791
84PRKCH0.38720506
85ERN10.37990587
86PKN20.36923858
87HIPK20.33542962
88STK240.33093818
89MKNK10.32659818
90EIF2AK20.32168601
91IKBKB0.31189935
92KSR20.30160602
93MTOR0.30029170
94MAP3K120.28600079
95PRKCA0.24716270
96INSR0.24624027
97MAPKAPK50.24390290
98MAPK70.23637178
99YES10.23547832
100RPS6KA20.23524330

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.60697810
2Nitrogen metabolism_Homo sapiens_hsa009102.59751879
3Phototransduction_Homo sapiens_hsa047442.34636841
4Tryptophan metabolism_Homo sapiens_hsa003802.04897669
5Caffeine metabolism_Homo sapiens_hsa0023210.4482496
6Sphingolipid metabolism_Homo sapiens_hsa006001.95506367
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.89748564
8Primary bile acid biosynthesis_Homo sapiens_hsa001201.86809127
9Chemical carcinogenesis_Homo sapiens_hsa052041.85373193
10Drug metabolism - other enzymes_Homo sapiens_hsa009831.79025603
11Maturity onset diabetes of the young_Homo sapiens_hsa049501.65583139
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.64016289
13Histidine metabolism_Homo sapiens_hsa003401.42024367
14Selenocompound metabolism_Homo sapiens_hsa004501.38154563
15Circadian rhythm_Homo sapiens_hsa047101.37587332
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34314390
17Starch and sucrose metabolism_Homo sapiens_hsa005001.32512739
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.31583387
19Retinol metabolism_Homo sapiens_hsa008301.29826300
20Glycerolipid metabolism_Homo sapiens_hsa005611.29571617
21Adherens junction_Homo sapiens_hsa045201.29373140
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.26233365
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23311742
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17621388
25Fructose and mannose metabolism_Homo sapiens_hsa000511.17531017
26Linoleic acid metabolism_Homo sapiens_hsa005911.12861482
27Bile secretion_Homo sapiens_hsa049761.06937621
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05150507
29ABC transporters_Homo sapiens_hsa020101.04993895
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01049847
31Steroid hormone biosynthesis_Homo sapiens_hsa001400.99840897
32Mineral absorption_Homo sapiens_hsa049780.96360600
33Ether lipid metabolism_Homo sapiens_hsa005650.94176521
34Lysine degradation_Homo sapiens_hsa003100.90686828
35Arginine and proline metabolism_Homo sapiens_hsa003300.83733008
36Insulin secretion_Homo sapiens_hsa049110.81320854
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78764198
38Protein digestion and absorption_Homo sapiens_hsa049740.78698685
39Cyanoamino acid metabolism_Homo sapiens_hsa004600.78652266
40Glycerophospholipid metabolism_Homo sapiens_hsa005640.78590995
41Dorso-ventral axis formation_Homo sapiens_hsa043200.77777244
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.74740840
43Fatty acid degradation_Homo sapiens_hsa000710.73299354
44Fat digestion and absorption_Homo sapiens_hsa049750.71033671
45Thyroid hormone synthesis_Homo sapiens_hsa049180.68072082
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65435124
47Salivary secretion_Homo sapiens_hsa049700.63645600
48ECM-receptor interaction_Homo sapiens_hsa045120.60042217
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59659898
50Butanoate metabolism_Homo sapiens_hsa006500.59201806
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58439495
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58042789
53Arachidonic acid metabolism_Homo sapiens_hsa005900.57090719
54Phenylalanine metabolism_Homo sapiens_hsa003600.55368276
55Tyrosine metabolism_Homo sapiens_hsa003500.52314781
56Complement and coagulation cascades_Homo sapiens_hsa046100.47876477
57PPAR signaling pathway_Homo sapiens_hsa033200.47535368
58* Olfactory transduction_Homo sapiens_hsa047400.47290606
59Pancreatic secretion_Homo sapiens_hsa049720.46885646
60Insulin resistance_Homo sapiens_hsa049310.46499940
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46307105
62Glucagon signaling pathway_Homo sapiens_hsa049220.46093729
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43825389
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43391097
65Propanoate metabolism_Homo sapiens_hsa006400.42559045
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41882042
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41018188
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40630860
69Prostate cancer_Homo sapiens_hsa052150.39915087
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.38388313
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37331296
72Fatty acid biosynthesis_Homo sapiens_hsa000610.36827576
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.36789445
74Fatty acid metabolism_Homo sapiens_hsa012120.35660425
75Renin secretion_Homo sapiens_hsa049240.35534687
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35216337
77Vitamin digestion and absorption_Homo sapiens_hsa049770.35080910
78Serotonergic synapse_Homo sapiens_hsa047260.34909002
79Ovarian steroidogenesis_Homo sapiens_hsa049130.34207898
80African trypanosomiasis_Homo sapiens_hsa051430.33885018
81TNF signaling pathway_Homo sapiens_hsa046680.29119825
82Choline metabolism in cancer_Homo sapiens_hsa052310.28990251
83Peroxisome_Homo sapiens_hsa041460.28932694
84Renin-angiotensin system_Homo sapiens_hsa046140.27739504
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27320453
86Other glycan degradation_Homo sapiens_hsa005110.26536251
87Hepatitis C_Homo sapiens_hsa051600.26427701
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25688394
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25567004
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24735154
91beta-Alanine metabolism_Homo sapiens_hsa004100.24602886
92Thyroid cancer_Homo sapiens_hsa052160.24260981
93Influenza A_Homo sapiens_hsa051640.21697576
94Focal adhesion_Homo sapiens_hsa045100.21431559
95Cocaine addiction_Homo sapiens_hsa050300.20197220
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19933013
97Inositol phosphate metabolism_Homo sapiens_hsa005620.19097568
98Tight junction_Homo sapiens_hsa045300.19037426
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.18428144
100Glutathione metabolism_Homo sapiens_hsa004800.18293468

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