OR2A9P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tachykinin receptor signaling pathway (GO:0007217)4.72378503
2cilium or flagellum-dependent cell motility (GO:0001539)4.71434767
3regulation of gene silencing by RNA (GO:0060966)4.65790081
4regulation of posttranscriptional gene silencing (GO:0060147)4.65790081
5regulation of gene silencing by miRNA (GO:0060964)4.65790081
6signal peptide processing (GO:0006465)4.21873170
7positive regulation of catecholamine secretion (GO:0033605)4.04984838
8thyroid hormone metabolic process (GO:0042403)3.98122038
9positive regulation of uterine smooth muscle contraction (GO:0070474)3.97195846
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.85277971
11tryptophan catabolic process (GO:0006569)3.80922793
12indole-containing compound catabolic process (GO:0042436)3.80922793
13indolalkylamine catabolic process (GO:0046218)3.80922793
14negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.70501775
15negative regulation of translation, ncRNA-mediated (GO:0040033)3.70501775
16regulation of translation, ncRNA-mediated (GO:0045974)3.70501775
17L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.67994649
18photoreceptor cell maintenance (GO:0045494)3.63926699
19indolalkylamine metabolic process (GO:0006586)3.61106414
20detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.47860457
21prenylation (GO:0097354)3.39598974
22protein prenylation (GO:0018342)3.39598974
23L-methionine salvage (GO:0071267)3.39482724
24L-methionine biosynthetic process (GO:0071265)3.39482724
25amino acid salvage (GO:0043102)3.39482724
26xenobiotic catabolic process (GO:0042178)3.39078478
27regulation of hippo signaling (GO:0035330)3.32921409
28response to nitrosative stress (GO:0051409)3.30153023
29DNA double-strand break processing (GO:0000729)3.24735305
30axoneme assembly (GO:0035082)3.24114738
31multicellular organism reproduction (GO:0032504)3.22093308
32branched-chain amino acid catabolic process (GO:0009083)3.18988906
33positive regulation of amino acid transport (GO:0051957)3.16051364
34tryptophan metabolic process (GO:0006568)3.15858730
35cilium movement (GO:0003341)3.15422881
36phospholipid scrambling (GO:0017121)3.15020552
37regulation of uterine smooth muscle contraction (GO:0070472)3.12275674
38regulation of B cell receptor signaling pathway (GO:0050855)3.08555421
39benzene-containing compound metabolic process (GO:0042537)3.05391843
40methionine biosynthetic process (GO:0009086)3.03453703
41thyroid hormone generation (GO:0006590)3.02115227
42establishment of protein localization to Golgi (GO:0072600)2.99287007
43regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.97504444
44cellular response to sterol (GO:0036315)2.92757087
45detection of light stimulus involved in sensory perception (GO:0050962)2.91482264
46detection of light stimulus involved in visual perception (GO:0050908)2.91482264
47histone H3-K36 demethylation (GO:0070544)2.84626154
48kidney morphogenesis (GO:0060993)2.83644393
49reflex (GO:0060004)2.79985364
50retinal cone cell development (GO:0046549)2.79526406
51sulfation (GO:0051923)2.78601049
52negative regulation of complement activation (GO:0045916)2.72093177
53epithelial cilium movement (GO:0003351)2.71287510
54cellular glucuronidation (GO:0052695)2.70261918
55axonemal dynein complex assembly (GO:0070286)2.68986165
56UDP-N-acetylglucosamine metabolic process (GO:0006047)2.67969236
57cellular ketone body metabolic process (GO:0046950)2.67226542
58regulation of keratinocyte proliferation (GO:0010837)2.66939186
59branched-chain amino acid metabolic process (GO:0009081)2.63547420
60positive regulation of amine transport (GO:0051954)2.61336652
61coenzyme catabolic process (GO:0009109)2.57873652
62protein K11-linked deubiquitination (GO:0035871)2.57179771
63androgen biosynthetic process (GO:0006702)2.56719860
64positive regulation of granulocyte differentiation (GO:0030854)2.55500344
65serotonin receptor signaling pathway (GO:0007210)2.55183187
66fucose catabolic process (GO:0019317)2.53897504
67L-fucose metabolic process (GO:0042354)2.53897504
68L-fucose catabolic process (GO:0042355)2.53897504
69synapsis (GO:0007129)2.50916921
70ketone body metabolic process (GO:1902224)2.49488220
71NAD biosynthetic process (GO:0009435)2.49151195
72glutathione derivative metabolic process (GO:1901685)2.48779667
73glutathione derivative biosynthetic process (GO:1901687)2.48779667
74positive regulation of vasculogenesis (GO:2001214)2.48610001
75negative regulation of activin receptor signaling pathway (GO:0032926)2.48250023
76lipid translocation (GO:0034204)2.47771142
77phospholipid translocation (GO:0045332)2.47771142
78uronic acid metabolic process (GO:0006063)2.47741580
79glucuronate metabolic process (GO:0019585)2.47741580
80regulation of gene silencing (GO:0060968)2.47012473
81negative regulation of phagocytosis (GO:0050765)2.45997905
82neural tube formation (GO:0001841)2.45817346
83nodal signaling pathway (GO:0038092)2.45639510
84replicative senescence (GO:0090399)2.44977194
85flavonoid metabolic process (GO:0009812)2.44635581
86regulation of vasculogenesis (GO:2001212)2.44211808
87regulation of phospholipase A2 activity (GO:0032429)2.44191945
88indole-containing compound metabolic process (GO:0042430)2.43731613
89motile cilium assembly (GO:0044458)2.43402387
90toxin transport (GO:1901998)2.42155704
91positive regulation of developmental pigmentation (GO:0048087)2.41384386
92amino-acid betaine transport (GO:0015838)2.38425607
93carnitine transport (GO:0015879)2.38425607
94negative regulation of humoral immune response (GO:0002921)2.38298680
95quaternary ammonium group transport (GO:0015697)2.38248422
96early endosome to late endosome transport (GO:0045022)2.36865603
97cytokine biosynthetic process (GO:0042089)2.35577174
98protein targeting to Golgi (GO:0000042)2.33056396
99negative regulation of JUN kinase activity (GO:0043508)2.31524769
100dopamine transport (GO:0015872)2.31367841

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.80334583
2GBX2_23144817_ChIP-Seq_PC3_Human3.35452548
3VDR_22108803_ChIP-Seq_LS180_Human2.81323927
4IGF1R_20145208_ChIP-Seq_DFB_Human2.68924566
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.55856045
6ZNF274_21170338_ChIP-Seq_K562_Hela2.42578573
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33400145
8FUS_26573619_Chip-Seq_HEK293_Human2.22461056
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.19978923
10P300_19829295_ChIP-Seq_ESCs_Human2.11707616
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11490317
12AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.11144661
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05548578
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04564019
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.03224021
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00430828
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99199039
18ER_23166858_ChIP-Seq_MCF-7_Human1.97039598
19EWS_26573619_Chip-Seq_HEK293_Human1.96997830
20BCAT_22108803_ChIP-Seq_LS180_Human1.91818139
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.89302171
22TAF15_26573619_Chip-Seq_HEK293_Human1.87717447
23AR_21572438_ChIP-Seq_LNCaP_Human1.80856326
24SMAD4_21799915_ChIP-Seq_A2780_Human1.78717388
25IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.72662955
26CBP_20019798_ChIP-Seq_JUKART_Human1.72662955
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.70681123
28CDX2_22108803_ChIP-Seq_LS180_Human1.67976784
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66443539
30STAT3_23295773_ChIP-Seq_U87_Human1.64533065
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.62439868
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61463001
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61341484
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59146967
35FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.58309671
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.55057470
37TCF4_22108803_ChIP-Seq_LS180_Human1.54373808
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.52871234
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50506215
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47334145
41FOXM1_26456572_ChIP-Seq_MCF-7_Human1.46836244
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45166489
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.44313414
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44311714
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43793022
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.43641621
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43136091
48TCF4_23295773_ChIP-Seq_U87_Human1.43025266
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42437930
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41665578
51CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.41419336
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.40568950
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.40295564
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38577146
55AR_25329375_ChIP-Seq_VCAP_Human1.38408431
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38345821
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36835901
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34624950
59RUNX2_22187159_ChIP-Seq_PCA_Human1.34603227
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33315373
61SMAD4_21741376_ChIP-Seq_EPCs_Human1.32550297
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29781716
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.29401706
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29301558
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28446674
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.27965329
67AHR_22903824_ChIP-Seq_MCF-7_Human1.27521843
68EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27481254
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26778668
70RXR_22108803_ChIP-Seq_LS180_Human1.24474492
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24405301
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20765213
73* NANOG_19829295_ChIP-Seq_ESCs_Human1.19358060
74* SOX2_19829295_ChIP-Seq_ESCs_Human1.19358060
75* GATA3_26560356_Chip-Seq_TH2_Human1.18251742
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18106681
77CJUN_26792858_Chip-Seq_BT549_Human1.17322401
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17263581
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16626222
80CRX_20693478_ChIP-Seq_RETINA_Mouse1.16109578
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15145841
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15145841
83CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.14857437
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12503282
85FOXA1_25329375_ChIP-Seq_VCAP_Human1.12503282
86PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.12160753
87TBL1_22424771_ChIP-Seq_293T_Human1.10869283
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10051076
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09826715
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.09140750
91AR_20517297_ChIP-Seq_VCAP_Human1.08903635
92ETV1_20927104_ChIP-Seq_GIST48_Human1.07883422
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06974883
94OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06924967
95GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.06774712
96NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06455811
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06455811
98PHF8_20622853_ChIP-Seq_HELA_Human1.06314251
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05781375
100TP53_22573176_ChIP-Seq_HFKS_Human1.04732419

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis4.29029158
2MP0008057_abnormal_DNA_replication3.71896139
3MP0002254_reproductive_system_inflammat3.13138787
4MP0002138_abnormal_hepatobiliary_system2.96481406
5MP0003136_yellow_coat_color2.58524474
6MP0003646_muscle_fatigue2.52797883
7MP0001501_abnormal_sleep_pattern2.44310327
8MP0008961_abnormal_basal_metabolism2.42548700
9MP0000372_irregular_coat_pigmentation2.26101578
10MP0010386_abnormal_urinary_bladder2.17380729
11MP0004043_abnormal_pH_regulation2.08389967
12MP0002102_abnormal_ear_morphology2.03327634
13MP0003763_abnormal_thymus_physiology2.00717459
14MP0005075_abnormal_melanosome_morpholog1.99949830
15MP0002396_abnormal_hematopoietic_system1.99034880
16MP0004381_abnormal_hair_follicle1.98330191
17MP0005551_abnormal_eye_electrophysiolog1.93240626
18MP0008004_abnormal_stomach_pH1.83725277
19MP0001984_abnormal_olfaction1.78896583
20MP0002638_abnormal_pupillary_reflex1.75102361
21MP0002277_abnormal_respiratory_mucosa1.68276460
22MP0008877_abnormal_DNA_methylation1.66139292
23MP0001764_abnormal_homeostasis1.57148102
24MP0000230_abnormal_systemic_arterial1.53533199
25MP0009697_abnormal_copulation1.52855754
26MP0001664_abnormal_digestion1.51325095
27MP0003878_abnormal_ear_physiology1.50235993
28MP0005377_hearing/vestibular/ear_phenot1.50235993
29MP0002132_abnormal_respiratory_system1.49275244
30MP0008058_abnormal_DNA_repair1.45324610
31MP0003941_abnormal_skin_development1.44739062
32MP0005253_abnormal_eye_physiology1.43057410
33MP0001188_hyperpigmentation1.42012062
34MP0003806_abnormal_nucleotide_metabolis1.35363311
35MP0001485_abnormal_pinna_reflex1.32548209
36MP0004484_altered_response_of1.32006012
37MP0004782_abnormal_surfactant_physiolog1.30378726
38MP0001756_abnormal_urination1.28720797
39MP0005174_abnormal_tail_pigmentation1.28605040
40MP0000538_abnormal_urinary_bladder1.28493767
41MP0000427_abnormal_hair_cycle1.28106629
42MP0008995_early_reproductive_senescence1.27825505
43MP0008872_abnormal_physiological_respon1.27164367
44MP0004883_abnormal_blood_vessel1.25938616
45MP0006054_spinal_hemorrhage1.25467765
46MP0002009_preneoplasia1.23821955
47MP0005647_abnormal_sex_gland1.23167776
48MP0003252_abnormal_bile_duct1.20120685
49MP0005410_abnormal_fertilization1.19081016
50MP0010368_abnormal_lymphatic_system1.18501450
51MP0002693_abnormal_pancreas_physiology1.18326747
52MP0003828_pulmonary_edema1.17955897
53MP0004264_abnormal_extraembryonic_tissu1.15121771
54MP0003724_increased_susceptibility_to1.12169457
55MP0003718_maternal_effect1.10947343
56MP0005595_abnormal_vascular_smooth1.07998946
57MP0005085_abnormal_gallbladder_physiolo1.07406537
58MP0003045_fibrosis1.06229701
59MP0002168_other_aberrant_phenotype1.05514282
60MP0004215_abnormal_myocardial_fiber1.05070614
61MP0002933_joint_inflammation1.05017746
62MP0002160_abnormal_reproductive_system1.04259010
63MP0002876_abnormal_thyroid_physiology1.03077026
64MP0003950_abnormal_plasma_membrane1.01617177
65MP0005332_abnormal_amino_acid0.99748091
66MP0003890_abnormal_embryonic-extraembry0.99456226
67MP0000470_abnormal_stomach_morphology0.99343121
68MP0006072_abnormal_retinal_apoptosis0.98872501
69MP0002405_respiratory_system_inflammati0.98310355
70MP0005389_reproductive_system_phenotype0.97990166
71MP0005395_other_phenotype0.96475858
72MP0001661_extended_life_span0.92593592
73MP0005376_homeostasis/metabolism_phenot0.91631525
74MP0006082_CNS_inflammation0.90645692
75MP0001879_abnormal_lymphatic_vessel0.90597750
76MP0009643_abnormal_urine_homeostasis0.89826469
77MP0005671_abnormal_response_to0.89431960
78MP0002136_abnormal_kidney_physiology0.88676453
79MP0010329_abnormal_lipoprotein_level0.87982541
80MP0005670_abnormal_white_adipose0.86475264
81MP0001986_abnormal_taste_sensitivity0.84778175
82MP0004272_abnormal_basement_membrane0.83619120
83MP0003868_abnormal_feces_composition0.82161599
84MP0005310_abnormal_salivary_gland0.81887026
85MP0001800_abnormal_humoral_immune0.80467878
86MP0002736_abnormal_nociception_after0.80341402
87MP0001929_abnormal_gametogenesis0.75819033
88MP0010678_abnormal_skin_adnexa0.75151447
89MP0005266_abnormal_metabolism0.74253877
90MP0001968_abnormal_touch/_nociception0.74245845
91MP0000703_abnormal_thymus_morphology0.73908778
92MP0002166_altered_tumor_susceptibility0.73306047
93MP0005164_abnormal_response_to0.71828057
94MP0003698_abnormal_male_reproductive0.71802699
95MP0002928_abnormal_bile_duct0.71232519
96MP0005379_endocrine/exocrine_gland_phen0.70572288
97MP0001919_abnormal_reproductive_system0.67920042
98MP0001270_distended_abdomen0.67896492
99MP0002090_abnormal_vision0.67851781
100MP0005220_abnormal_exocrine_pancreas0.65196823

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.76618098
2Absent rod-and cone-mediated responses on ERG (HP:0007688)3.60058250
3Pancreatic fibrosis (HP:0100732)3.57388543
4Attenuation of retinal blood vessels (HP:0007843)3.44549641
5Dynein arm defect of respiratory motile cilia (HP:0012255)3.39063592
6Absent/shortened dynein arms (HP:0200106)3.39063592
7True hermaphroditism (HP:0010459)3.38560219
8Abnormal ciliary motility (HP:0012262)3.25776549
9Abnormal rod and cone electroretinograms (HP:0008323)3.17404213
10Chronic hepatic failure (HP:0100626)3.02512854
11Large for gestational age (HP:0001520)2.86705556
12Thyroiditis (HP:0100646)2.77646689
13Gaze-evoked nystagmus (HP:0000640)2.77117977
14Abolished electroretinogram (ERG) (HP:0000550)2.76561360
15Decreased circulating renin level (HP:0003351)2.71330562
16Abnormal respiratory motile cilium physiology (HP:0012261)2.71261128
17Short hallux (HP:0010109)2.68425743
18Chronic bronchitis (HP:0004469)2.67998661
19Ketosis (HP:0001946)2.67493945
20Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.67199290
21Abnormality of the renal collecting system (HP:0004742)2.61322477
22Hypothermia (HP:0002045)2.59965110
23Cystic liver disease (HP:0006706)2.58659403
24Congenital stationary night blindness (HP:0007642)2.54664966
25Congenital sensorineural hearing impairment (HP:0008527)2.51853315
26Stomach cancer (HP:0012126)2.45192478
27Aplasia/Hypoplasia of the hallux (HP:0008362)2.43068826
28Abnormality of midbrain morphology (HP:0002418)2.40158685
29Molar tooth sign on MRI (HP:0002419)2.40158685
30Pancreatic islet-cell hyperplasia (HP:0004510)2.40047293
31Medial flaring of the eyebrow (HP:0010747)2.36438362
32Bronchiectasis (HP:0002110)2.33299250
33Abnormality of the intrinsic pathway (HP:0010989)2.32652208
34Absent speech (HP:0001344)2.32357844
35Abnormal respiratory motile cilium morphology (HP:0005938)2.31433174
36Abnormal respiratory epithelium morphology (HP:0012253)2.31433174
37Abnormality of the renal medulla (HP:0100957)2.30601173
38Hyperactive renin-angiotensin system (HP:0000841)2.28521816
39Clumsiness (HP:0002312)2.28095980
40Bile duct proliferation (HP:0001408)2.26823313
41Abnormal biliary tract physiology (HP:0012439)2.26823313
42Furrowed tongue (HP:0000221)2.26762773
43Nephronophthisis (HP:0000090)2.25443348
44Bronchitis (HP:0012387)2.24930401
45Hyperinsulinemic hypoglycemia (HP:0000825)2.24848127
46Decreased central vision (HP:0007663)2.24660309
47Autoimmune hemolytic anemia (HP:0001890)2.20377561
48Hematochezia (HP:0002573)2.19599930
49Stomatitis (HP:0010280)2.18761461
50Lipid accumulation in hepatocytes (HP:0006561)2.16935334
51Constricted visual fields (HP:0001133)2.16534716
52Clubbing of toes (HP:0100760)2.16058672
53Abnormality of the pancreatic islet cells (HP:0006476)2.15050595
54Abnormality of endocrine pancreas physiology (HP:0012093)2.15050595
55Duplicated collecting system (HP:0000081)2.11486445
56Male pseudohermaphroditism (HP:0000037)2.07852064
57Bony spicule pigmentary retinopathy (HP:0007737)2.07254035
58Abnormality of renin-angiotensin system (HP:0000847)2.05154088
59Ketoacidosis (HP:0001993)2.04760789
60Hypokalemic alkalosis (HP:0001949)2.04093595
61Facial diplegia (HP:0001349)2.01485334
62Macular degeneration (HP:0000608)2.00840404
63Protruding tongue (HP:0010808)1.99029115
64Abnormality of vitamin B metabolism (HP:0004340)1.98731387
65Metabolic alkalosis (HP:0200114)1.98160857
66Rhinitis (HP:0012384)1.95936486
67Recurrent bronchitis (HP:0002837)1.95320973
68Abnormality of T cell number (HP:0011839)1.94982323
69Abnormality of the vitamin B12 metabolism (HP:0004341)1.93574955
70Intestinal atresia (HP:0011100)1.91974919
71Hyperkalemia (HP:0002153)1.90996970
72Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89473177
73Abnormal protein N-linked glycosylation (HP:0012347)1.89473177
74Abnormal protein glycosylation (HP:0012346)1.89473177
75Abnormal glycosylation (HP:0012345)1.89473177
76Polyuria (HP:0000103)1.86961763
77Congenital hepatic fibrosis (HP:0002612)1.86461463
78Aplasia/Hypoplasia of the tongue (HP:0010295)1.85714762
79Abnormal drinking behavior (HP:0030082)1.85498195
80Polydipsia (HP:0001959)1.85498195
81Widely spaced teeth (HP:0000687)1.84597888
82Abnormality of chromosome stability (HP:0003220)1.82071632
83Cupped ear (HP:0000378)1.80341215
84Tubular atrophy (HP:0000092)1.77491177
85Central scotoma (HP:0000603)1.76654358
86Anencephaly (HP:0002323)1.76019950
87Sloping forehead (HP:0000340)1.75988590
88Genetic anticipation (HP:0003743)1.74821904
89Reduced antithrombin III activity (HP:0001976)1.73966634
90Abnormality of macular pigmentation (HP:0008002)1.73792134
91Hyperglycinemia (HP:0002154)1.73591979
92Panhypogammaglobulinemia (HP:0003139)1.73496283
93Hyperaldosteronism (HP:0000859)1.73375317
94Biliary tract neoplasm (HP:0100574)1.73199149
95Chronic sinusitis (HP:0011109)1.72684887
96Congenital primary aphakia (HP:0007707)1.71982482
97Methylmalonic aciduria (HP:0012120)1.71833187
98Scotoma (HP:0000575)1.71796965
99Occipital encephalocele (HP:0002085)1.71643555
100Genital tract atresia (HP:0001827)1.70907384

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.68121976
2LATS13.42565523
3BCKDK3.08477516
4EIF2AK32.91264664
5MST42.70211822
6STK38L2.51850283
7NLK2.47846061
8NUAK12.27759305
9ACVR1B2.19335371
10PINK12.14717864
11MARK32.01894780
12WNK31.97675980
13BMPR1B1.93985793
14ADRBK21.91978867
15FGFR21.80910496
16TXK1.75605832
17MYLK1.70851408
18OXSR11.70198757
19GRK11.59253678
20AKT31.56132380
21MAPK151.51088980
22BRSK21.49973422
23ZAK1.39984951
24INSRR1.35375150
25TEC1.32987551
26TNIK1.29479405
27TAOK31.26588622
28TAF11.24380581
29TIE11.23142975
30STK31.17285828
31MKNK21.16800190
32STK381.13010532
33SGK21.10064279
34FER1.10015460
35CASK1.06595580
36ITK1.05657203
37TGFBR10.99502812
38CDK30.97840903
39MAP4K10.96444707
40PRKCQ0.92035711
41KIT0.90949680
42MELK0.85891748
43STK390.84414621
44IKBKE0.82748718
45PIK3CG0.80740821
46BTK0.78122038
47PTK2B0.77793757
48PRKCE0.77763255
49ADRBK10.74652159
50CSNK1G10.74640236
51IRAK10.72592107
52SGK2230.72049656
53SGK4940.72049656
54NEK20.68171283
55STK240.67107811
56KDR0.64597444
57GRK60.63943623
58TNK20.62870911
59PAK30.62142193
60MUSK0.61873822
61FGFR10.61115955
62ERBB30.57043164
63PBK0.55086831
64PRKG20.54137868
65VRK10.53836554
66TGFBR20.53682037
67TRPM70.53128448
68FGFR30.52036926
69IGF1R0.51220018
70CSNK1A1L0.47992096
71MAP3K40.47697397
72PLK30.45618324
73EGFR0.45087832
74MKNK10.43398272
75MST1R0.43123906
76PRKAA20.42996168
77OBSCN0.42626673
78JAK10.42225284
79LCK0.41467992
80MAPK70.40168210
81SGK30.40071169
82STK110.39760867
83MAP4K20.38227248
84SIK30.36384001
85IKBKB0.36366054
86PASK0.36125853
87PIK3CA0.34909361
88ABL10.34261730
89MAP3K70.31848254
90EIF2AK20.31664049
91ATM0.29790573
92GRK50.29784353
93MAP2K60.29479207
94PRKCH0.27160552
95CSNK1D0.26323854
96FLT30.26256876
97MAP2K70.23409266
98JAK30.23130327
99MAPK130.21349376
100TRIM280.21206842

Predicted pathways (KEGG)

RankGene SetZ-score
1Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.55222603
2Butanoate metabolism_Homo sapiens_hsa006502.54985237
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.23226991
4Linoleic acid metabolism_Homo sapiens_hsa005912.22781742
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.17880160
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.16072089
7Retinol metabolism_Homo sapiens_hsa008302.15649150
8Phototransduction_Homo sapiens_hsa047442.13077830
9Propanoate metabolism_Homo sapiens_hsa006402.12792107
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.12696187
11Chemical carcinogenesis_Homo sapiens_hsa052042.09613954
12ABC transporters_Homo sapiens_hsa020102.06882029
13Tryptophan metabolism_Homo sapiens_hsa003802.00098033
14Nitrogen metabolism_Homo sapiens_hsa009101.97644097
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.94280109
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.80550241
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77639221
18Olfactory transduction_Homo sapiens_hsa047401.68159947
19Primary immunodeficiency_Homo sapiens_hsa053401.68084991
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.64594289
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.63169732
22Circadian rhythm_Homo sapiens_hsa047101.58094720
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.53110221
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52121266
25Histidine metabolism_Homo sapiens_hsa003401.50896100
26Non-homologous end-joining_Homo sapiens_hsa034501.45707728
27Taste transduction_Homo sapiens_hsa047421.40170089
28Ether lipid metabolism_Homo sapiens_hsa005651.38059475
29Selenocompound metabolism_Homo sapiens_hsa004501.36879036
30Glycerolipid metabolism_Homo sapiens_hsa005611.35450319
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.34833673
32Vascular smooth muscle contraction_Homo sapiens_hsa042701.34338289
33Arachidonic acid metabolism_Homo sapiens_hsa005901.33409610
34beta-Alanine metabolism_Homo sapiens_hsa004101.26925735
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26198766
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15291834
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14426481
38Renin secretion_Homo sapiens_hsa049241.14120590
39Starch and sucrose metabolism_Homo sapiens_hsa005001.12654847
40Sulfur relay system_Homo sapiens_hsa041221.12489079
41Sphingolipid metabolism_Homo sapiens_hsa006001.08520630
42Fatty acid degradation_Homo sapiens_hsa000711.06976208
43Basal transcription factors_Homo sapiens_hsa030221.06493241
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04254509
45Ovarian steroidogenesis_Homo sapiens_hsa049131.01483077
46Vitamin digestion and absorption_Homo sapiens_hsa049770.98434971
47Salivary secretion_Homo sapiens_hsa049700.96224849
48Homologous recombination_Homo sapiens_hsa034400.94545785
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93618524
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93175966
51Glycerophospholipid metabolism_Homo sapiens_hsa005640.92971150
52Serotonergic synapse_Homo sapiens_hsa047260.91869375
53Lysine degradation_Homo sapiens_hsa003100.90485132
54Dorso-ventral axis formation_Homo sapiens_hsa043200.90039993
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88621885
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87005836
57RNA degradation_Homo sapiens_hsa030180.86683177
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82030608
59Platelet activation_Homo sapiens_hsa046110.81302794
60Graft-versus-host disease_Homo sapiens_hsa053320.79806509
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.79681744
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78888409
63Fanconi anemia pathway_Homo sapiens_hsa034600.74158551
64Peroxisome_Homo sapiens_hsa041460.73760269
65One carbon pool by folate_Homo sapiens_hsa006700.72128709
66Type I diabetes mellitus_Homo sapiens_hsa049400.65905341
67Autoimmune thyroid disease_Homo sapiens_hsa053200.65220184
68Pancreatic secretion_Homo sapiens_hsa049720.64387487
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63470503
70T cell receptor signaling pathway_Homo sapiens_hsa046600.62856353
71Glutathione metabolism_Homo sapiens_hsa004800.60904143
72Calcium signaling pathway_Homo sapiens_hsa040200.60867200
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60561794
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60332604
75RNA polymerase_Homo sapiens_hsa030200.56951914
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.54065835
77Circadian entrainment_Homo sapiens_hsa047130.52760077
78Regulation of autophagy_Homo sapiens_hsa041400.51812069
79Hematopoietic cell lineage_Homo sapiens_hsa046400.51361566
80Purine metabolism_Homo sapiens_hsa002300.50450848
81Fat digestion and absorption_Homo sapiens_hsa049750.48775172
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48585381
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.48000863
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47805687
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46813388
86Mineral absorption_Homo sapiens_hsa049780.46146721
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.44663919
88N-Glycan biosynthesis_Homo sapiens_hsa005100.44384897
89Tight junction_Homo sapiens_hsa045300.44305834
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40555361
91Metabolic pathways_Homo sapiens_hsa011000.40329722
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38279141
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35418704
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34407530
95Gastric acid secretion_Homo sapiens_hsa049710.33255503
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32828450
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.30830074
98Insulin resistance_Homo sapiens_hsa049310.30030389
99Caffeine metabolism_Homo sapiens_hsa002320.29462509
100Allograft rejection_Homo sapiens_hsa053300.27858159

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