OR2AD1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of RNA splicing (GO:0033120)9.65134546
2seminiferous tubule development (GO:0072520)9.57464979
3negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)9.22221224
4cAMP biosynthetic process (GO:0006171)8.83821256
5detection of chemical stimulus involved in sensory perception (GO:0050907)8.47146781
6negative regulation of alpha-beta T cell differentiation (GO:0046639)8.39522546
7enteric nervous system development (GO:0048484)7.86983394
8regulation of protein sumoylation (GO:0033233)7.53383988
9synaptic transmission, dopaminergic (GO:0001963)7.05632853
10positive regulation of mitochondrial fission (GO:0090141)6.99007033
11dendritic spine morphogenesis (GO:0060997)6.98114135
12righting reflex (GO:0060013)6.93934198
13heterotypic cell-cell adhesion (GO:0034113)6.52926310
14positive regulation of T-helper 1 type immune response (GO:0002827)6.32932417
15detection of chemical stimulus (GO:0009593)6.09884200
16hepatocyte apoptotic process (GO:0097284)6.06646454
17icosanoid secretion (GO:0032309)6.04938077
18arachidonic acid secretion (GO:0050482)6.04938077
19endothelial cell differentiation (GO:0045446)5.95182928
20positive regulation of T-helper cell differentiation (GO:0045624)5.82291089
21phosphatidylinositol acyl-chain remodeling (GO:0036149)5.49868543
22drug transmembrane transport (GO:0006855)5.24277929
23regulation of mitochondrial fission (GO:0090140)5.13928772
24phosphatidylserine acyl-chain remodeling (GO:0036150)5.13467479
25phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.02203865
26icosanoid transport (GO:0071715)5.01207543
27fatty acid derivative transport (GO:1901571)5.01207543
28neuronal ion channel clustering (GO:0045161)4.98211960
29negative regulation of alpha-beta T cell activation (GO:0046636)4.88025191
30chemosensory behavior (GO:0007635)4.77411454
31neural tube formation (GO:0001841)4.76534030
32hyaluronan catabolic process (GO:0030214)4.73359170
33regulation of T-helper 1 type immune response (GO:0002825)4.57775174
34cilium or flagellum-dependent cell motility (GO:0001539)4.54131901
35embryonic digestive tract morphogenesis (GO:0048557)4.49935930
36positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.44954775
37cyclic purine nucleotide metabolic process (GO:0052652)4.41274415
38nephron epithelium morphogenesis (GO:0072088)4.36630353
39nephron tubule morphogenesis (GO:0072078)4.36630353
40vocalization behavior (GO:0071625)4.32439285
41ATP hydrolysis coupled proton transport (GO:0015991)4.31072120
42energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.31072120
43retina layer formation (GO:0010842)4.30259842
44cyclic nucleotide biosynthetic process (GO:0009190)4.26816981
45positive regulation of membrane potential (GO:0045838)4.26502489
46regulation of T-helper cell differentiation (GO:0045622)4.24269432
47attachment of spindle microtubules to kinetochore (GO:0008608)4.23628690
48regulation of cAMP-mediated signaling (GO:0043949)4.21659517
49cellular response to glucagon stimulus (GO:0071377)4.19376108
50negative regulation of actin filament bundle assembly (GO:0032232)4.18956443
51regulation of type 2 immune response (GO:0002828)4.18836180
52response to dietary excess (GO:0002021)4.18533978
53water transport (GO:0006833)4.07908836
54mitochondrial fusion (GO:0008053)4.01100565
55cAMP metabolic process (GO:0046058)3.99886388
56dendritic spine organization (GO:0097061)3.97654104
57protein localization to synapse (GO:0035418)3.96536287
58positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.92212320
59cytoskeletal anchoring at plasma membrane (GO:0007016)3.85027725
60negative regulation of cytosolic calcium ion concentration (GO:0051481)3.83017586
61cellular zinc ion homeostasis (GO:0006882)3.73692734
62monoamine transport (GO:0015844)3.72191544
63negative regulation of T cell differentiation (GO:0045581)3.71354906
64fluid transport (GO:0042044)3.64269605
65phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.62712597
66leukotriene biosynthetic process (GO:0019370)3.60259756
67drug transport (GO:0015893)3.58049988
68positive regulation of protein targeting to membrane (GO:0090314)3.54457791
69pre-miRNA processing (GO:0031054)3.52231743
70cellular response to ATP (GO:0071318)3.50413262
71sulfur amino acid catabolic process (GO:0000098)3.48315762
72sequestering of metal ion (GO:0051238)3.44287072
73negative regulation of homotypic cell-cell adhesion (GO:0034111)3.41034740
74positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.37067320
75positive regulation of alpha-beta T cell differentiation (GO:0046638)3.36655282
76regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.35285561
77left/right axis specification (GO:0070986)3.30055262
78negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.16652431
79neurofilament cytoskeleton organization (GO:0060052)3.15211438
80neuromuscular process controlling posture (GO:0050884)3.14156848
81phosphatidylcholine acyl-chain remodeling (GO:0036151)3.14154244
82renal tubule morphogenesis (GO:0061333)3.14013716
83response to glucagon (GO:0033762)3.12716954
84positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.12286225
85negative regulation of astrocyte differentiation (GO:0048712)3.10689664
86prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.10275260
87exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07864969
88adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.07280405
89adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.06020204
90positive regulation of steroid hormone secretion (GO:2000833)3.04457483
91tooth mineralization (GO:0034505)14.3772480
92detection of chemical stimulus involved in sensory perception of smell (GO:0050911)13.6360666
93positive regulation of protein sumoylation (GO:0033235)11.9764404
94negative regulation of T-helper cell differentiation (GO:0045623)11.4671776
95negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)11.4671776
96protein K11-linked deubiquitination (GO:0035871)10.6434704
97regulation of T-helper 1 cell differentiation (GO:0045625)10.3294387
98regulation of T-helper 2 cell differentiation (GO:0045628)10.1663297
99negative regulation of type 2 immune response (GO:0002829)10.1119990
100activation of protein kinase A activity (GO:0034199)10.0771315

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.48761367
2EGR1_19374776_ChIP-ChIP_THP-1_Human5.61028774
3IGF1R_20145208_ChIP-Seq_DFB_Human4.76983308
4AR_21572438_ChIP-Seq_LNCaP_Human4.75571562
5VDR_22108803_ChIP-Seq_LS180_Human4.21807992
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.45965226
7TP53_16413492_ChIP-PET_HCT116_Human2.16191555
8PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.04958979
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse10.7157987
10YY1_22570637_ChIP-Seq_MALME-3M_Human1.90841221
11ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.88786664
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88553171
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.86498439
14TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86498439
15GATA1_19941826_ChIP-Seq_K562_Human1.80154749
16NR3C1_23031785_ChIP-Seq_PC12_Mouse1.66861913
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63790258
18DROSHA_22980978_ChIP-Seq_HELA_Human1.62888087
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.56907563
20RNF2_27304074_Chip-Seq_ESCs_Mouse1.55998042
21EGR1_19032775_ChIP-ChIP_M12_Human1.55494813
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.50996477
23SMAD3_21741376_ChIP-Seq_HESCs_Human1.45927781
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.44359364
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.43592882
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43243063
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39611670
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.38676834
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33845620
30SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33442585
31SMAD3_21741376_ChIP-Seq_EPCs_Human1.33217276
32RXR_22108803_ChIP-Seq_LS180_Human1.26134723
33RNF2_27304074_Chip-Seq_NSC_Mouse1.25285612
34NANOG_18555785_Chip-Seq_ESCs_Mouse1.23369661
35TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.22634127
36CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18394578
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17163990
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16796837
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.12195485
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11911134
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11262449
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11256693
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.08380818
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06432726
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05876739
46HNFA_21074721_ChIP-Seq_CACO-2_Human1.05663087
47GBX2_23144817_ChIP-Seq_PC3_Human1.05246099
48SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04229656
49SOX2_18555785_Chip-Seq_ESCs_Mouse1.04017357
50ER_23166858_ChIP-Seq_MCF-7_Human1.03986226
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03334388
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.03273213
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03088544
54EZH2_22144423_ChIP-Seq_EOC_Human1.02996696
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01020508
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01012046
57TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99577447
58ARNT_22903824_ChIP-Seq_MCF-7_Human0.99497791
59PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99492678
60PRDM14_20953172_ChIP-Seq_ESCs_Human0.99391892
61GATA6_21074721_ChIP-Seq_CACO-2_Human0.99275070
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98377807
63KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97163737
64SMAD4_21741376_ChIP-Seq_HESCs_Human0.96297940
65TBL1_22424771_ChIP-Seq_293T_Human0.95991274
66BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95900872
67CMYC_18555785_Chip-Seq_ESCs_Mouse0.95776909
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95477607
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93644103
70STAT3_23295773_ChIP-Seq_U87_Human0.91409043
71CJUN_26792858_Chip-Seq_BT549_Human0.90719423
72PHF8_20622853_ChIP-Seq_HELA_Human0.90294520
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89365313
74BCAT_22108803_ChIP-Seq_LS180_Human0.87931875
75GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.87811304
76TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87355644
77NANOG_16518401_ChIP-PET_MESCs_Mouse0.85684696
78SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85258766
79TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85218161
80CTCF_27219007_Chip-Seq_Bcells_Human0.84499994
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84247574
82CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.83576176
83PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.82380503
84E2F1_18555785_Chip-Seq_ESCs_Mouse0.82038524
85RNF2_18974828_ChIP-Seq_MESCs_Mouse0.82035163
86EZH2_18974828_ChIP-Seq_MESCs_Mouse0.82035163
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81830964
88NMYC_18555785_Chip-Seq_ESCs_Mouse0.81755821
89KLF4_18555785_Chip-Seq_ESCs_Mouse0.81607624
90ETV2_25802403_ChIP-Seq_MESCs_Mouse0.80711839
91REST_21632747_ChIP-Seq_MESCs_Mouse0.79327107
92EZH2_27294783_Chip-Seq_NPCs_Mouse0.78305921
93GATA2_19941826_ChIP-Seq_K562_Human0.77553516
94RING1B_27294783_Chip-Seq_ESCs_Mouse0.76111151
95SMAD4_21799915_ChIP-Seq_A2780_Human0.75334253
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74789519
97FOXO3_23340844_ChIP-Seq_DLD1_Human0.74701932
98CTBP2_25329375_ChIP-Seq_LNCAP_Human0.74331894
99P53_22387025_ChIP-Seq_ESCs_Mouse0.74257532
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.73750795

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism9.76538315
2MP0004130_abnormal_muscle_cell5.04110767
3MP0004264_abnormal_extraembryonic_tissu4.03221989
4MP0003252_abnormal_bile_duct3.62298163
5MP0004133_heterotaxia2.81654940
6MP0002928_abnormal_bile_duct2.73741847
7MP0006072_abnormal_retinal_apoptosis2.42299382
8MP0005448_abnormal_energy_balance2.32377567
9MP0005408_hypopigmentation2.24480536
10MP0002751_abnormal_autonomic_nervous2.22971331
11MP0003329_amyloid_beta_deposits2.12312137
12MP0001270_distended_abdomen2.11283206
13MP0004272_abnormal_basement_membrane2.09472649
14MP0005084_abnormal_gallbladder_morpholo12.6371675
15MP0003943_abnormal_hepatobiliary_system1.76160036
16MP0005220_abnormal_exocrine_pancreas1.65363848
17MP0005379_endocrine/exocrine_gland_phen1.64379076
18MP0005165_increased_susceptibility_to1.56469031
19MP0009764_decreased_sensitivity_to1.45679674
20MP0001958_emphysema1.39785607
21MP0000604_amyloidosis1.36317268
22MP0001529_abnormal_vocalization1.30439446
23MP0003718_maternal_effect1.22285688
24MP0005646_abnormal_pituitary_gland1.09109334
25MP0000465_gastrointestinal_hemorrhage1.08499968
26MP0000470_abnormal_stomach_morphology1.01904729
27MP0001905_abnormal_dopamine_level1.01801539
28MP0002909_abnormal_adrenal_gland0.99478112
29MP0001944_abnormal_pancreas_morphology0.99457115
30MP0002572_abnormal_emotion/affect_behav0.97631279
31MP0008569_lethality_at_weaning0.94541814
32MP0003638_abnormal_response/metabolism_0.93212430
33MP0008469_abnormal_protein_level0.79730291
34MP0001800_abnormal_humoral_immune0.79305921
35MP0005164_abnormal_response_to0.79273370
36MP0001915_intracranial_hemorrhage0.79104462
37MP0000371_diluted_coat_color0.78446661
38MP0002405_respiratory_system_inflammati0.77770407
39MP0003121_genomic_imprinting0.77230469
40MP0004019_abnormal_vitamin_homeostasis0.75526872
41MP0003866_abnormal_defecation0.72629294
42MP0002693_abnormal_pancreas_physiology0.72519563
43MP0000609_abnormal_liver_physiology0.71713085
44MP0000703_abnormal_thymus_morphology0.69080313
45MP0002098_abnormal_vibrissa_morphology0.68661891
46MP0008875_abnormal_xenobiotic_pharmacok0.65809362
47MP0001851_eye_inflammation0.65691538
48MP0005253_abnormal_eye_physiology0.65159498
49MP0001790_abnormal_immune_system0.64626856
50MP0005387_immune_system_phenotype0.64626856
51MP0004947_skin_inflammation0.63398686
52MP0001533_abnormal_skeleton_physiology0.63224570
53MP0002078_abnormal_glucose_homeostasis0.63039246
54MP0002136_abnormal_kidney_physiology0.62942632
55MP0003953_abnormal_hormone_level0.61797415
56MP0002998_abnormal_bone_remodeling0.57992983
57MP0001845_abnormal_inflammatory_respons0.51325479
58MP0002722_abnormal_immune_system0.48291018
59MP0009642_abnormal_blood_homeostasis0.47253866
60MP0003195_calcinosis0.47060698
61MP0005551_abnormal_eye_electrophysiolog0.40998851
62MP0005334_abnormal_fat_pad0.40438439
63MP0002419_abnormal_innate_immunity0.39912851
64MP0002822_catalepsy0.39140965
65MP0002429_abnormal_blood_cell0.39118590
66MP0005365_abnormal_bile_salt0.37774143
67MP0000920_abnormal_myelination0.37318808
68MP0000759_abnormal_skeletal_muscle0.36925263
69MP0002452_abnormal_antigen_presenting0.36821336
70MP0000477_abnormal_intestine_morphology0.36471340
71MP0000598_abnormal_liver_morphology0.36333907
72MP0008004_abnormal_stomach_pH0.35927199
73MP0004484_altered_response_of0.35792739
74MP0001501_abnormal_sleep_pattern0.34089717
75MP0009931_abnormal_skin_appearance0.34082968
76MP0002420_abnormal_adaptive_immunity0.33788037
77MP0000716_abnormal_immune_system0.33523464
78MP0002882_abnormal_neuron_morphology0.33363080
79MP0001819_abnormal_immune_cell0.33153990
80MP0005423_abnormal_somatic_nervous0.32712420
81MP0001986_abnormal_taste_sensitivity0.32372482
82MP0002398_abnormal_bone_marrow0.32142538
83MP0005390_skeleton_phenotype0.32091568
84MP0001835_abnormal_antigen_presentation0.31420184
85MP0002229_neurodegeneration0.30759721
86MP0002723_abnormal_immune_serum0.30663085
87MP0001299_abnormal_eye_distance/0.29948276
88MP0005000_abnormal_immune_tolerance0.28577428
89MP0005395_other_phenotype0.27671925
90MP0002735_abnormal_chemical_nociception0.26776666
91MP0001175_abnormal_lung_morphology0.26698316
92MP0000689_abnormal_spleen_morphology0.26503389
93MP0003136_yellow_coat_color0.23636796
94MP0009053_abnormal_anal_canal0.22720173
95MP0002066_abnormal_motor_capabilities/c0.22698851
96MP0002396_abnormal_hematopoietic_system0.21861676
97MP0002128_abnormal_blood_circulation0.21481222
98MP0000249_abnormal_blood_vessel0.20679994
99MP0005391_vision/eye_phenotype0.19625299
100MP0006276_abnormal_autonomic_nervous0.19264805

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of dental color (HP:0011073)8.29630294
2Abnormality of renal resorption (HP:0011038)8.10741963
3Osteomalacia (HP:0002749)7.87312484
4Polyuria (HP:0000103)7.63881411
5Abnormality of the dental pulp (HP:0006479)7.61374408
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.79332623
7Abnormal urine output (HP:0012590)6.53892014
8Abnormality of renal excretion (HP:0011036)5.70773763
9Round ear (HP:0100830)5.44763620
10Chronic bronchitis (HP:0004469)4.93357401
11Volvulus (HP:0002580)4.32121612
12Lip pit (HP:0100267)4.26422535
13IgM deficiency (HP:0002850)4.26054514
14Autoimmune thrombocytopenia (HP:0001973)4.08870468
15Toxemia of pregnancy (HP:0100603)4.00829411
16Nephrocalcinosis (HP:0000121)3.87842703
17Molar tooth sign on MRI (HP:0002419)3.87754315
18Abnormality of midbrain morphology (HP:0002418)3.87754315
19Esophageal varix (HP:0002040)3.86647162
20Lipoatrophy (HP:0100578)3.40704660
21Depressed nasal tip (HP:0000437)3.37407434
22Sparse lateral eyebrow (HP:0005338)3.34980025
23Large earlobe (HP:0009748)3.29691728
24Abnormal respiratory motile cilium physiology (HP:0012261)3.28875030
25Rhinitis (HP:0012384)3.25427534
26Tachypnea (HP:0002789)3.21983368
27Drooling (HP:0002307)3.18560646
28Hypoparathyroidism (HP:0000829)3.13193653
29Intestinal fistula (HP:0100819)3.09177399
30Excessive salivation (HP:0003781)3.05877185
31Panhypogammaglobulinemia (HP:0003139)3.04565486
32Thick eyebrow (HP:0000574)2.89496100
33Hyperphosphaturia (HP:0003109)2.87460545
34Personality changes (HP:0000751)2.87047282
35Petechiae (HP:0000967)2.70606669
36Nephronophthisis (HP:0000090)2.63924229
37Ureteral stenosis (HP:0000071)2.60369113
38Hepatitis (HP:0012115)2.55728103
39Dilated cardiomyopathy (HP:0001644)2.53555686
40Abnormality of the fingertips (HP:0001211)2.52441867
41Short 5th finger (HP:0009237)2.45122394
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.42721045
43Abnormal urine phosphate concentration (HP:0012599)2.42399975
44Ureteral obstruction (HP:0006000)2.39988959
45Chronic mucocutaneous candidiasis (HP:0002728)2.39494744
46Recurrent cutaneous fungal infections (HP:0011370)2.39494744
47Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.34276249
48Glycosuria (HP:0003076)2.32519094
49Abnormality of urine glucose concentration (HP:0011016)2.32519094
50Abnormality of transition element cation homeostasis (HP:0011030)2.32512197
51Striae distensae (HP:0001065)2.32175074
52Gingival overgrowth (HP:0000212)2.31541197
53Sudden cardiac death (HP:0001645)2.27728878
54Colitis (HP:0002583)2.26663298
55Nephropathy (HP:0000112)2.24170419
56Hypercalciuria (HP:0002150)2.19687132
57Preauricular pit (HP:0004467)2.15679860
58Periauricular skin pits (HP:0100277)2.15679860
59Bronchitis (HP:0012387)2.14770323
60Inability to walk (HP:0002540)2.13631363
61Recurrent otitis media (HP:0000403)2.10622347
62Agammaglobulinemia (HP:0004432)2.10106772
63Decreased muscle mass (HP:0003199)2.09589804
64Anal stenosis (HP:0002025)2.03584598
65Abnormality of salivation (HP:0100755)2.02317784
66Overgrowth (HP:0001548)12.2985175
67Amelogenesis imperfecta (HP:0000705)11.6923511
68Abnormality of calcium-phosphate metabolism (HP:0100530)10.1106494
69Delayed eruption of teeth (HP:0000684)1.99138541
70Abnormality of the renal medulla (HP:0100957)1.98976076
71Chondrocalcinosis (HP:0000934)1.96359119
72Abnormality of Sharpey fibers (HP:0100685)1.91688281
73Chorioretinal coloboma (HP:0000567)1.88406290
74Ectopic kidney (HP:0000086)1.86498412
75Truncal ataxia (HP:0002078)1.84072024
76Preauricular skin tag (HP:0000384)1.83817453
77Prominent supraorbital ridges (HP:0000336)1.82282399
78Renal tubular dysfunction (HP:0000124)1.77338074
79Stage 5 chronic kidney disease (HP:0003774)1.75119491
80Limited elbow extension (HP:0001377)1.73606184
81Abnormality of small intestinal villus morphology (HP:0011472)1.65737290
82Villous atrophy (HP:0011473)1.65737290
83Small hand (HP:0200055)1.64701508
84Torticollis (HP:0000473)1.61755438
85Oculomotor apraxia (HP:0000657)1.59424615
86Ectropion (HP:0000656)1.57581161
87Skin tags (HP:0010609)1.57078822
88Polyneuropathy (HP:0001271)1.56270400
89Palmoplantar keratoderma (HP:0000982)1.56259392
90Blepharitis (HP:0000498)1.52516368
91Bronchiectasis (HP:0002110)1.51639385
92Skin pits (HP:0100276)1.50120216
93Prenatal maternal abnormality (HP:0002686)1.48945781
94Viral hepatitis (HP:0006562)1.45492885
95Mask-like facies (HP:0000298)1.43073581
96Inflammation of the large intestine (HP:0002037)1.42800780
97Highly arched eyebrow (HP:0002553)1.42444314
98Proximal placement of thumb (HP:0009623)1.41687543
99Osteoarthritis (HP:0002758)1.37176836
100Aplasia/Hypoplasia of the earlobes (HP:0009906)1.29598665

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.70158258
2BLK4.34877126
3STK34.13551126
4RIPK43.22608670
5CDC42BPA2.17241747
6BMPR22.11945362
7NTRK214.1932195
8HIPK21.26801573
9FGFR10.91579677
10INSRR0.82413531
11ROCK20.78230896
12SYK0.69356250
13SRC0.63373905
14PRKCQ0.60060857
15OBSCN0.59909149
16PRKAA10.58000469
17MUSK0.55761532
18ROCK10.53855600
19TXK0.52210044
20MAP4K20.49466332
21GRK70.46619087
22PRKACG0.43855912
23WNK30.42967022
24ABL10.42237017
25MAPK150.42002153
26TIE10.40729625
27GRK10.40575356
28ADRBK20.38798255
29PRKACA0.36030531
30PRKACB0.35244859
31PIK3CG0.33827724
32CAMK2A0.32415233
33SRPK10.32114322
34ERBB40.28889567
35LYN0.26536068
36PLK10.23306512
37EPHA40.23175802
38MATK0.22868643
39PRKCA0.22426230
40MAPK140.22391153
41GSK3B0.21885306
42TEC0.21502495
43ITK0.21330736
44PRKCB0.20977496
45FRK0.20678919
46RPS6KA30.20529534
47PLK40.19535106
48KDR0.19366995
49MST1R0.19093062
50LMTK20.18991937
51KIT0.18776762
52FYN0.18145019
53TTN0.17545885
54GRK50.16807805
55DDR20.16470964
56PHKG20.15747270
57PHKG10.15747270
58TLK10.15402415
59PIM20.14305195
60CDK10.14107081
61GRK60.13806590
62CHUK0.13759197
63CSNK1A10.13564892
64PRKCD0.13190655
65BTK0.12553054
66MAP2K60.12507437
67EPHA20.12352560
68LCK0.11306394
69OXSR10.11265812
70HCK0.10228032
71ADRBK10.10189448
72MAPK90.10171121
73TNK20.09856082
74WNK40.09724747
75PRKDC0.09282154
76PRKCG0.08730848
77PIM10.08490039
78PKN10.07951342
79IGF1R0.07937260
80EGFR0.07251970
81AKT10.06024733
82TGFBR20.05970931
83PIK3CA0.05433779
84CAMK2G0.05043728
85IKBKE0.04880764
86TAOK20.04809976
87PRKG10.03631442
88INSR0.03582146
89MAP3K30.03113469
90PRKG20.03050313
91ABL20.03025440
92PRKCE0.02740753
93STK390.02421447
94MYLK0.02310034
95SGK10.02300334
96MAPK40.02286743
97ZAK0.02129585
98PINK10.01991705
99UHMK10.01988931
100NTRK10.01664055

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.27519932
2Sulfur relay system_Homo sapiens_hsa041223.72665549
3Sulfur metabolism_Homo sapiens_hsa009203.65996863
4Ovarian steroidogenesis_Homo sapiens_hsa049133.35244613
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.17666346
6Linoleic acid metabolism_Homo sapiens_hsa005912.91040205
7Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.88638898
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.74605164
9Collecting duct acid secretion_Homo sapiens_hsa049662.50762090
10Vibrio cholerae infection_Homo sapiens_hsa051102.38087224
11Bile secretion_Homo sapiens_hsa049762.37651647
12Thyroid hormone synthesis_Homo sapiens_hsa049182.21966217
13Pancreatic secretion_Homo sapiens_hsa049722.21391833
14Salivary secretion_Homo sapiens_hsa049702.13866666
15Fat digestion and absorption_Homo sapiens_hsa049752.11553187
16Gastric acid secretion_Homo sapiens_hsa049712.10108265
17Synaptic vesicle cycle_Homo sapiens_hsa047212.04306618
18Cocaine addiction_Homo sapiens_hsa050301.93567430
19Circadian entrainment_Homo sapiens_hsa047131.84982773
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.82638560
21Insulin secretion_Homo sapiens_hsa049111.79186738
22Vascular smooth muscle contraction_Homo sapiens_hsa042701.75431096
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74200822
24Taste transduction_Homo sapiens_hsa047421.72338822
25Glutamatergic synapse_Homo sapiens_hsa047241.72176785
26GABAergic synapse_Homo sapiens_hsa047271.68536879
27Morphine addiction_Homo sapiens_hsa050321.68386252
28Dilated cardiomyopathy_Homo sapiens_hsa054141.65947495
29Longevity regulating pathway - mammal_Homo sapiens_hsa042111.63506272
30Ether lipid metabolism_Homo sapiens_hsa005651.61180760
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56207861
32Gap junction_Homo sapiens_hsa045401.54467227
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.44819615
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44189397
35Amphetamine addiction_Homo sapiens_hsa050311.40694944
36GnRH signaling pathway_Homo sapiens_hsa049121.38569085
37Melanogenesis_Homo sapiens_hsa049161.34235035
38Arachidonic acid metabolism_Homo sapiens_hsa005901.30612825
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26141793
40Platelet activation_Homo sapiens_hsa046111.17575607
41Oxytocin signaling pathway_Homo sapiens_hsa049211.17304933
42Cholinergic synapse_Homo sapiens_hsa047251.14410952
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13740707
44Estrogen signaling pathway_Homo sapiens_hsa049151.07551590
45Calcium signaling pathway_Homo sapiens_hsa040201.06730950
46Circadian rhythm_Homo sapiens_hsa047101.00290025
47Dorso-ventral axis formation_Homo sapiens_hsa043200.87939633
48Pyruvate metabolism_Homo sapiens_hsa006200.79021026
49Serotonergic synapse_Homo sapiens_hsa047260.76747384
50ECM-receptor interaction_Homo sapiens_hsa045120.73490872
51Chemokine signaling pathway_Homo sapiens_hsa040620.73431958
52Oocyte meiosis_Homo sapiens_hsa041140.72673099
53Rheumatoid arthritis_Homo sapiens_hsa053230.69276343
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64154474
55RNA degradation_Homo sapiens_hsa030180.53940837
56cAMP signaling pathway_Homo sapiens_hsa040240.46950915
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46676645
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.43036191
59Alcoholism_Homo sapiens_hsa050340.39220609
60Primary immunodeficiency_Homo sapiens_hsa053400.38846953
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38646738
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34215466
63Dopaminergic synapse_Homo sapiens_hsa047280.33656886
64Staphylococcus aureus infection_Homo sapiens_hsa051500.33453247
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.33394785
66Parkinsons disease_Homo sapiens_hsa050120.29081658
67Prion diseases_Homo sapiens_hsa050200.27978538
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.27128259
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.24448080
70Rap1 signaling pathway_Homo sapiens_hsa040150.24262871
71Purine metabolism_Homo sapiens_hsa002300.23678906
72Retinol metabolism_Homo sapiens_hsa008300.20694558
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.19619732
74Hedgehog signaling pathway_Homo sapiens_hsa043400.17951994
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.16596443
76Glucagon signaling pathway_Homo sapiens_hsa049220.14531452
77Phagosome_Homo sapiens_hsa041450.14493664
78Tuberculosis_Homo sapiens_hsa051520.14421973
79Systemic lupus erythematosus_Homo sapiens_hsa053220.13631889
80Type I diabetes mellitus_Homo sapiens_hsa049400.13211082
81Ras signaling pathway_Homo sapiens_hsa040140.12970513
82Oxidative phosphorylation_Homo sapiens_hsa001900.12453912
83HTLV-I infection_Homo sapiens_hsa051660.11631375
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.10272475
85Caffeine metabolism_Homo sapiens_hsa002320.10166065
86Leishmaniasis_Homo sapiens_hsa051400.09660843
87African trypanosomiasis_Homo sapiens_hsa051430.09397463
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.07938924
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.07641212
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.06961027
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.06956110
92Hematopoietic cell lineage_Homo sapiens_hsa046400.06642180
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.05773790
94Chemical carcinogenesis_Homo sapiens_hsa052040.04818199
95Renin secretion_Homo sapiens_hsa049240.04597059
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.04279548
97Nicotine addiction_Homo sapiens_hsa050330.03269850
98Asthma_Homo sapiens_hsa053100.03065460
99Amoebiasis_Homo sapiens_hsa051460.00513067
100Autoimmune thyroid disease_Homo sapiens_hsa05320-0.0015234

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