OR2B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tooth mineralization (GO:0034505)8.67416055
2resolution of meiotic recombination intermediates (GO:0000712)7.90252654
3quaternary ammonium group transport (GO:0015697)7.77847184
4drug transmembrane transport (GO:0006855)7.66551172
5neurotransmitter biosynthetic process (GO:0042136)7.54952605
6organic cation transport (GO:0015695)7.45469152
7positive regulation of meiosis (GO:0045836)6.67804098
8bone trabecula formation (GO:0060346)6.66911167
9exogenous drug catabolic process (GO:0042738)6.46959255
10neurotransmitter metabolic process (GO:0042133)6.43409813
11fatty acid elongation (GO:0030497)6.27503094
12positive regulation of meiotic cell cycle (GO:0051446)6.20493789
13azole transport (GO:0045117)5.78116400
14positive regulation of immune response to tumor cell (GO:0002839)5.68216205
15regulation of immune response to tumor cell (GO:0002837)5.68216205
16regulation of response to tumor cell (GO:0002834)5.68216205
17positive regulation of response to tumor cell (GO:0002836)5.68216205
18synaptonemal complex assembly (GO:0007130)5.54301899
19histone H3-K36 demethylation (GO:0070544)5.49861116
20histone-serine phosphorylation (GO:0035404)5.47122428
21drug transport (GO:0015893)5.35117864
22positive regulation of hair cycle (GO:0042635)5.28835820
23positive regulation of hair follicle development (GO:0051798)5.28835820
24epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)5.10936803
25synaptonemal complex organization (GO:0070193)4.98466801
26drug catabolic process (GO:0042737)4.98423922
27pathway-restricted SMAD protein phosphorylation (GO:0060389)4.90363246
28positive regulation of protein homodimerization activity (GO:0090073)4.82576144
29reciprocal meiotic recombination (GO:0007131)4.75146408
30reciprocal DNA recombination (GO:0035825)4.75146408
31cilium or flagellum-dependent cell motility (GO:0001539)4.60534586
32rRNA catabolic process (GO:0016075)4.57532373
33negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.47379594
34regulation of mesenchymal cell apoptotic process (GO:2001053)4.43938466
35fatty acid transmembrane transport (GO:1902001)4.42296455
36negative regulation of epidermal cell differentiation (GO:0045605)4.41236658
37cranial suture morphogenesis (GO:0060363)4.38455427
38negative regulation of telomere maintenance (GO:0032205)4.30715987
39negative regulation of transcription regulatory region DNA binding (GO:2000678)4.29736735
40regulation of meiosis I (GO:0060631)4.26341389
41wound healing, spreading of epidermal cells (GO:0035313)4.24341959
42carnitine shuttle (GO:0006853)4.19939868
43behavioral response to nicotine (GO:0035095)4.16664572
44endothelium development (GO:0003158)4.13625926
45negative regulation of calcium ion transport into cytosol (GO:0010523)4.07135026
46protein neddylation (GO:0045116)3.98501236
47chromosome organization involved in meiosis (GO:0070192)3.92261694
48positive regulation of mast cell activation (GO:0033005)3.91144366
49positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.90936836
50L-phenylalanine catabolic process (GO:0006559)3.82112951
51erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.82112951
52histone phosphorylation (GO:0016572)3.61115488
53* detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.56835295
54arginine catabolic process (GO:0006527)3.54667091
55tyrosine metabolic process (GO:0006570)3.51668171
56negative regulation by host of viral transcription (GO:0043922)3.46649508
57regulation of hair follicle development (GO:0051797)3.38253486
58protein K6-linked ubiquitination (GO:0085020)3.37088218
59regulation of energy homeostasis (GO:2000505)3.35862227
60triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.35511250
61C4-dicarboxylate transport (GO:0015740)3.31264554
62secretory granule organization (GO:0033363)3.27030301
63negative regulation of epidermis development (GO:0045683)3.22359780
64regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.21695052
65outflow tract septum morphogenesis (GO:0003148)3.14612253
66erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.13875602
67L-phenylalanine metabolic process (GO:0006558)3.13875602
68regulation of hippo signaling (GO:0035330)3.12615925
69negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.09087557
70carnitine transmembrane transport (GO:1902603)3.08218876
71positive regulation of toll-like receptor signaling pathway (GO:0034123)3.03381731
72regulation of activation of Janus kinase activity (GO:0010533)3.00852881
73trabecula formation (GO:0060343)3.00730251
74negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.00701291
75activin receptor signaling pathway (GO:0032924)2.96477066
76aromatic amino acid family catabolic process (GO:0009074)2.89127496
77retinal cone cell development (GO:0046549)2.88359006
78thrombin receptor signaling pathway (GO:0070493)2.86045397
79leukocyte migration involved in inflammatory response (GO:0002523)2.83167598
80carnitine transport (GO:0015879)2.82608490
81amino-acid betaine transport (GO:0015838)2.82608490
82negative regulation of neurotransmitter transport (GO:0051589)2.80196440
83cellular response to estradiol stimulus (GO:0071392)2.79962915
84regulation of meiosis (GO:0040020)2.78604650
85negative regulation of neural precursor cell proliferation (GO:2000178)2.78239704
86negative regulation of TOR signaling (GO:0032007)2.78124038
87lysosome localization (GO:0032418)2.74288681
88nephron epithelium morphogenesis (GO:0072088)2.72884806
89nephron tubule morphogenesis (GO:0072078)2.72884806
90regulation of MHC class I biosynthetic process (GO:0045343)2.69517332
91synapsis (GO:0007129)2.68824303
92rRNA methylation (GO:0031167)2.66969467
93* detection of chemical stimulus involved in sensory perception (GO:0050907)2.66881173
94positive regulation by host of viral transcription (GO:0043923)2.66188065
95dopamine transport (GO:0015872)2.63729455
96positive regulation of natural killer cell mediated immunity (GO:0002717)2.61822329
97positive regulation of T cell mediated cytotoxicity (GO:0001916)2.59567640
98regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.58941903
99histamine transport (GO:0051608)10.3210866
100meiotic chromosome segregation (GO:0045132)10.0796981

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human9.00914408
2IRF1_19129219_ChIP-ChIP_H3396_Human3.79099938
3ZNF274_21170338_ChIP-Seq_K562_Hela3.62097225
4SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.69252511
5PCGF2_27294783_Chip-Seq_NPCs_Mouse2.56105067
6EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.42217962
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.42165938
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.33646148
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.33182761
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.06723889
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.05662094
12GBX2_23144817_ChIP-Seq_PC3_Human1.94066083
13EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.89419912
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.86119537
15NANOG_19829295_ChIP-Seq_ESCs_Human1.79593361
16SOX2_19829295_ChIP-Seq_ESCs_Human1.79593361
17* NANOG_20526341_ChIP-Seq_ESCs_Human1.74761325
18FOXH1_21741376_ChIP-Seq_ESCs_Human1.73061761
19TDRD3_21172665_ChIP-Seq_MCF-7_Human1.68326680
20EWS_26573619_Chip-Seq_HEK293_Human1.63222517
21LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.63118138
22FOXM1_23109430_ChIP-Seq_U2OS_Human1.57070164
23TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.51737772
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49387183
25* OCT1_27270436_Chip-Seq_PROSTATE_Human1.49155072
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46983788
27IGF1R_20145208_ChIP-Seq_DFB_Human1.45114488
28* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.43385615
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43377991
30EGR1_19032775_ChIP-ChIP_M12_Human1.40375365
31RAC3_21632823_ChIP-Seq_H3396_Human1.39323202
32GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39313716
33POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37688755
34TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37688755
35SMAD4_21741376_ChIP-Seq_EPCs_Human1.36606925
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35463245
37GATA1_19941826_ChIP-Seq_K562_Human1.34262900
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33530577
39RNF2_27304074_Chip-Seq_NSC_Mouse1.32920115
40JUN_21703547_ChIP-Seq_K562_Human1.32691106
41TCF4_23295773_ChIP-Seq_U87_Human1.32309662
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.27450794
43FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25983983
44STAT3_23295773_ChIP-Seq_U87_Human1.25004092
45GATA2_19941826_ChIP-Seq_K562_Human1.23417774
46AR_20517297_ChIP-Seq_VCAP_Human1.22744770
47P53_21459846_ChIP-Seq_SAOS-2_Human1.22624733
48GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.21545383
49EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21454514
50* E2F1_20622854_ChIP-Seq_HELA_Human1.18671213
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16673082
52TP53_22573176_ChIP-Seq_HFKS_Human1.16085822
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14102814
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13814576
55GATA3_26560356_Chip-Seq_TH1_Human1.13216275
56TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.12751300
57GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12557865
58SMAD4_21799915_ChIP-Seq_A2780_Human1.11876783
59P300_27268052_Chip-Seq_Bcells_Human1.11858409
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11528455
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11084695
62TAF2_19829295_ChIP-Seq_ESCs_Human1.10820108
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.09665881
64SPI1_23127762_ChIP-Seq_K562_Human1.08240724
65CEBPB_22108803_ChIP-Seq_LS180_Human1.06056262
66* BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.05815378
67FOXH1_21741376_ChIP-Seq_EPCs_Human1.05616394
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05448122
69HOXB7_26014856_ChIP-Seq_BT474_Human1.04578608
70MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01566142
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00602669
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99784595
73ERA_21632823_ChIP-Seq_H3396_Human0.99686230
74NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99335398
75OCT4_20526341_ChIP-Seq_ESCs_Human0.99135802
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98985046
77LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98655984
78NCOR_22424771_ChIP-Seq_293T_Human0.98564884
79CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98529438
80FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97141044
81PRDM14_20953172_ChIP-Seq_ESCs_Human0.96804067
82ETS1_22383799_ChIP-Seq_G1ME_Mouse0.96629772
83SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96314789
84NFE2_27457419_Chip-Seq_LIVER_Mouse0.95975702
85GATA3_26560356_Chip-Seq_TH2_Human0.94143955
86* AR_25329375_ChIP-Seq_VCAP_Human0.93965591
87ER_23166858_ChIP-Seq_MCF-7_Human0.93742367
88* PHF8_20622854_ChIP-Seq_HELA_Human0.92092101
89BCAT_22108803_ChIP-Seq_LS180_Human0.92053848
90TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.91551152
91IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91228125
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90013151
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89562530
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88985311
95CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88453591
96RUNX2_22187159_ChIP-Seq_PCA_Human0.87807018
97JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85104122
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84736480
99P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.84379109
100EZH2_27294783_Chip-Seq_NPCs_Mouse0.83825880

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis6.50330829
2MP0003646_muscle_fatigue6.24786793
3MP0005167_abnormal_blood-brain_barrier3.70884248
4MP0002837_dystrophic_cardiac_calcinosis2.99533354
5MP0004043_abnormal_pH_regulation2.86437705
6MP0005464_abnormal_platelet_physiology2.85490234
7MP0004130_abnormal_muscle_cell2.84151851
8MP0008872_abnormal_physiological_respon2.80202507
9MP0001919_abnormal_reproductive_system2.60324657
10MP0002160_abnormal_reproductive_system2.56937328
11MP0005645_abnormal_hypothalamus_physiol2.42857011
12MP0003136_yellow_coat_color2.41249768
13MP0004084_abnormal_cardiac_muscle2.33116860
14MP0004381_abnormal_hair_follicle2.28578304
15MP0003329_amyloid_beta_deposits2.24117731
16MP0005410_abnormal_fertilization2.13814530
17MP0008004_abnormal_stomach_pH2.12073815
18MP0001873_stomach_inflammation2.09408861
19MP0005389_reproductive_system_phenotype1.95289872
20MP0002163_abnormal_gland_morphology1.95035260
21MP0004147_increased_porphyrin_level1.90899529
22MP0000372_irregular_coat_pigmentation1.83487590
23MP0008775_abnormal_heart_ventricle1.82749559
24MP0010329_abnormal_lipoprotein_level1.76804631
25MP0005647_abnormal_sex_gland1.74654617
26MP0001440_abnormal_grooming_behavior1.66427934
27MP0006276_abnormal_autonomic_nervous1.66103733
28MP0002139_abnormal_hepatobiliary_system1.63899011
29MP0003045_fibrosis1.60117293
30MP0002138_abnormal_hepatobiliary_system1.58449099
31MP0008875_abnormal_xenobiotic_pharmacok1.53936413
32MP0005085_abnormal_gallbladder_physiolo1.53683027
33MP0004858_abnormal_nervous_system1.49141631
34MP0001664_abnormal_digestion1.46658694
35MP0003195_calcinosis1.41843148
36MP0005266_abnormal_metabolism1.37298263
37MP0004233_abnormal_muscle_weight1.37189554
38MP0008877_abnormal_DNA_methylation1.32879052
39MP0005084_abnormal_gallbladder_morpholo1.29327697
40MP0005551_abnormal_eye_electrophysiolog1.27919630
41MP0002733_abnormal_thermal_nociception1.27176733
42MP0004484_altered_response_of1.25440738
43MP0004883_abnormal_blood_vessel1.23254393
44MP0003718_maternal_effect1.13561743
45MP0005365_abnormal_bile_salt1.11454637
46MP0001835_abnormal_antigen_presentation1.11262577
47MP0006054_spinal_hemorrhage1.10500989
48MP0003566_abnormal_cell_adhesion1.06558702
49MP0002210_abnormal_sex_determination1.05351444
50MP0006036_abnormal_mitochondrial_physio1.02874748
51MP0009333_abnormal_splenocyte_physiolog1.01040513
52MP0000049_abnormal_middle_ear0.99537928
53MP0009643_abnormal_urine_homeostasis0.98145888
54MP0000470_abnormal_stomach_morphology0.96698374
55MP0005448_abnormal_energy_balance0.95768056
56MP0000230_abnormal_systemic_arterial0.95726852
57MP0001879_abnormal_lymphatic_vessel0.92331715
58MP0005360_urolithiasis0.91607203
59MP0009745_abnormal_behavioral_response0.91227783
60MP0002876_abnormal_thyroid_physiology0.91076358
61MP0000427_abnormal_hair_cycle0.90687843
62MP0004036_abnormal_muscle_relaxation0.89964706
63MP0003698_abnormal_male_reproductive0.89869771
64MP0003252_abnormal_bile_duct0.89134877
65MP0001663_abnormal_digestive_system0.88723732
66MP0001968_abnormal_touch/_nociception0.87819509
67MP0000604_amyloidosis0.84303143
68MP0003632_abnormal_nervous_system0.84157866
69MP0001790_abnormal_immune_system0.83722578
70MP0005387_immune_system_phenotype0.83722578
71MP0003186_abnormal_redox_activity0.83117975
72MP0010307_abnormal_tumor_latency0.81622139
73MP0003638_abnormal_response/metabolism_0.79891561
74MP0000858_altered_metastatic_potential0.78410387
75MP0004142_abnormal_muscle_tone0.76822310
76MP0002148_abnormal_hypersensitivity_rea0.74882223
77MP0002557_abnormal_social/conspecific_i0.74234599
78MP0004134_abnormal_chest_morphology0.73704050
79MP0003693_abnormal_embryo_hatching0.73266598
80MP0009697_abnormal_copulation0.73013395
81MP0006138_congestive_heart_failure0.72825776
82MP0005379_endocrine/exocrine_gland_phen0.72473303
83MP0004215_abnormal_myocardial_fiber0.69020502
84MP0005646_abnormal_pituitary_gland0.68152254
85MP0001970_abnormal_pain_threshold0.67324011
86MP0005332_abnormal_amino_acid0.66636784
87MP0001286_abnormal_eye_development0.66176102
88MP0000747_muscle_weakness0.65670506
89MP0004145_abnormal_muscle_electrophysio0.65261042
90MP0001986_abnormal_taste_sensitivity0.64635360
91MP0001929_abnormal_gametogenesis0.64216748
92MP0001145_abnormal_male_reproductive0.64216582
93MP0005671_abnormal_response_to0.61094517
94MP0000653_abnormal_sex_gland0.59223898
95MP0001346_abnormal_lacrimal_gland0.59164066
96MP0010368_abnormal_lymphatic_system0.59066925
97MP0009764_decreased_sensitivity_to0.58874031
98MP0002089_abnormal_postnatal_growth/wei0.58454182
99MP0006035_abnormal_mitochondrial_morpho0.57296485
100MP0002132_abnormal_respiratory_system0.57012423

Predicted human phenotypes

RankGene SetZ-score
1Unilateral renal agenesis (HP:0000122)9.41434314
2Hypoplasia of the fovea (HP:0007750)8.05658991
3Aplasia/Hypoplasia of the fovea (HP:0008060)8.05658991
4Bilateral microphthalmos (HP:0007633)7.36347799
5Conjugated hyperbilirubinemia (HP:0002908)6.90924756
6Abnormality of the fovea (HP:0000493)6.45702649
7Aplasia cutis congenita (HP:0001057)5.69048215
8Fused cervical vertebrae (HP:0002949)5.26381273
9Aplasia/Hypoplasia of the macula (HP:0008059)5.25619438
10Aplasia/Hypoplasia affecting the retina (HP:0008061)4.90880628
11Abnormality of the right ventricle (HP:0001707)4.77721787
12Abnormality of the parietal bone (HP:0002696)4.52177762
13Progressive inability to walk (HP:0002505)4.48861890
143-Methylglutaconic aciduria (HP:0003535)4.20355885
15Hyperlipoproteinemia (HP:0010980)4.14576912
16Widely patent fontanelles and sutures (HP:0004492)4.09120287
17Abnormality of transition element cation homeostasis (HP:0011030)4.08309184
18Mixed hearing impairment (HP:0000410)3.93542846
19Central scotoma (HP:0000603)3.70452747
20Prolonged bleeding time (HP:0003010)3.42654114
21Congenital stationary night blindness (HP:0007642)3.31650077
22Decreased central vision (HP:0007663)3.30050322
23Menorrhagia (HP:0000132)3.29171150
24Concave nail (HP:0001598)3.19012731
25Lissencephaly (HP:0001339)3.18750359
26Aplasia/Hypoplasia of the optic nerve (HP:0008058)3.15729807
27CNS hypomyelination (HP:0003429)3.07382058
28Inability to walk (HP:0002540)3.04185379
29Abnormality of iron homeostasis (HP:0011031)3.00266408
30Lower limb hyperreflexia (HP:0002395)2.80961288
31Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.63346446
32Hip dysplasia (HP:0001385)2.59037288
33Posterior subcapsular cataract (HP:0007787)2.56258173
34Tubular atrophy (HP:0000092)2.52390949
35Vertebral fusion (HP:0002948)2.43381472
36Abnormal delayed hypersensitivity skin test (HP:0002963)2.39735346
37Increased mean platelet volume (HP:0011877)2.37351143
38Increased neuronal autofluorescent lipopigment (HP:0002074)2.35051209
39Sensorimotor neuropathy (HP:0007141)2.33758052
40Clitoromegaly (HP:0000057)2.26893135
41Ulnar deviation of the wrist (HP:0003049)2.25007048
42Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.22553352
43Attenuation of retinal blood vessels (HP:0007843)2.21760118
44Bony spicule pigmentary retinopathy (HP:0007737)2.21317777
45Wide cranial sutures (HP:0010537)2.19091932
46Arthropathy (HP:0003040)2.18882237
47Metabolic alkalosis (HP:0200114)2.17600182
48Brushfield spots (HP:0001088)2.15624059
49Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12141619
50Bulbous nose (HP:0000414)2.11939048
51Stomatitis (HP:0010280)2.11012035
52Abnormal platelet volume (HP:0011876)2.10225950
53Scotoma (HP:0000575)2.07561352
54Increased serum ferritin (HP:0003281)2.00292326
55Abnormality of proline metabolism (HP:0010907)1.97687482
56Hydroxyprolinuria (HP:0003080)1.97687482
57Gaze-evoked nystagmus (HP:0000640)1.97211231
58Sprengel anomaly (HP:0000912)1.96468796
59Renal tubular acidosis (HP:0001947)1.96361569
60Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93547367
61Abnormality of midbrain morphology (HP:0002418)1.92257237
62Molar tooth sign on MRI (HP:0002419)1.92257237
63Tetraplegia (HP:0002445)1.92067064
64Abnormality of the renal cortex (HP:0011035)1.91006477
65Epistaxis (HP:0000421)1.90149344
66Birth length less than 3rd percentile (HP:0003561)1.88743483
67Progressive cerebellar ataxia (HP:0002073)1.86535928
68Severe muscular hypotonia (HP:0006829)1.86413554
69Hyperglycinuria (HP:0003108)1.85021876
70Petechiae (HP:0000967)1.83716223
71Triphalangeal thumb (HP:0001199)1.83601626
72Conical tooth (HP:0000698)1.83580227
73Hypoplasia of the uterus (HP:0000013)1.81391881
74Increased cerebral lipofuscin (HP:0011813)1.80994745
75Abnormality of the clitoris (HP:0000056)1.77928252
76Constricted visual fields (HP:0001133)1.77870939
77Hyperbilirubinemia (HP:0002904)1.75553966
78Cerebral palsy (HP:0100021)1.75544224
79Febrile seizures (HP:0002373)1.74433835
80Premature skin wrinkling (HP:0100678)1.72446427
81Partial agenesis of the corpus callosum (HP:0001338)1.72391348
82Dysmetric saccades (HP:0000641)1.68694647
83Purpura (HP:0000979)1.68135567
84Abnormality of alanine metabolism (HP:0010916)1.68106514
85Hyperalaninemia (HP:0003348)1.68106514
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68106514
87Multifactorial inheritance (HP:0001426)1.67750689
88Short clavicles (HP:0000894)1.66405617
89Hepatosplenomegaly (HP:0001433)1.64758836
90Autoimmune thrombocytopenia (HP:0001973)1.63712331
91Renal agenesis (HP:0000104)1.63193331
92Joint swelling (HP:0001386)1.63004608
93Prominent nose (HP:0000448)1.60592715
94Ectopic anus (HP:0004397)1.60340466
95Abnormality of polysaccharide metabolism (HP:0011012)1.59885553
96Abnormality of glycosaminoglycan metabolism (HP:0004371)1.59885553
97Abnormality of mucopolysaccharide metabolism (HP:0011020)1.59885553
98Decreased circulating renin level (HP:0003351)1.55765507
99Xanthomatosis (HP:0000991)1.54348286
100Poikilocytosis (HP:0004447)1.53086755

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK49.38190972
2BMPR25.57251061
3TLK14.71181046
4SIK33.70804387
5PINK13.30742413
6SIK23.20153949
7NEK22.34873312
8MAP3K72.26951141
9SIK12.26294420
10ADRBK22.03376443
11ERBB21.99142576
12MAP3K111.89157201
13ICK1.80324878
14MST41.68040772
15BTK1.64297226
16ACVR1B1.61366782
17STK111.57189149
18MARK31.52423755
19STK31.44521115
20TAOK31.39374587
21DAPK21.36158313
22MAPKAPK31.25213741
23TIE11.22674883
24MELK1.16353636
25FRK1.16291178
26PTK2B1.12376923
27TEC1.08193909
28PRKAA21.02929775
29EEF2K0.98065250
30BMPR1B0.92917198
31MAPKAPK50.92110153
32CAMK10.88286939
33SYK0.86219501
34ILK0.85461112
35STK380.83881621
36BMX0.83493355
37BCR0.78611566
38FLT30.74590417
39NUAK10.73778383
40TRPM70.72001791
41PRKAA10.68721287
42PRKCI0.67333837
43CDK120.62644153
44CAMK40.62260378
45ADRBK10.57185035
46GRK10.55561358
47IRAK10.52191028
48BRSK20.52030741
49GRK50.51555871
50MAP2K10.51460869
51CHEK20.50043882
52TXK0.47729278
53WNK30.46501945
54PRKCG0.43673116
55RPS6KA60.42470941
56MAPK130.41805018
57MATK0.41795560
58PLK40.40029019
59CAMK1D0.38940995
60MYLK0.37032482
61PIK3CA0.36978066
62MAP3K120.36395532
63MAP2K40.35934273
64PIK3CG0.35596242
65STK38L0.33875702
66DAPK10.33460423
67PRKACG0.32862719
68CAMK1G0.32749667
69PRKCZ0.30896817
70MAP3K30.30484779
71CDC42BPA0.29775377
72JAK30.28502262
73ZAP700.28247313
74ZAK0.28048751
75MAP3K10.27613053
76PKN10.26494015
77MARK20.26122926
78MET0.23862734
79HIPK20.23588400
80PRKCA0.23013210
81CAMKK20.22399461
82IGF1R0.21944418
83TRIM280.21685621
84MAP3K50.20866023
85CAMK2A0.20660303
86RET0.19954734
87ITK0.17919848
88PAK10.17676066
89TNK20.17272835
90PRKCB0.17021499
91CDK40.16750823
92NTRK10.16746261
93TAF10.15788716
94OXSR10.14752197
95TGFBR10.14438871
96ATR0.12626004
97EIF2AK10.12490195
98MAPK40.12072254
99RPS6KL10.11997047
100RPS6KC10.11997047

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.60630361
2* Olfactory transduction_Homo sapiens_hsa047403.35459871
3Fatty acid elongation_Homo sapiens_hsa000622.72099005
4Linoleic acid metabolism_Homo sapiens_hsa005912.51535089
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.41524818
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.39844776
7Choline metabolism in cancer_Homo sapiens_hsa052312.24958198
8Nitrogen metabolism_Homo sapiens_hsa009102.06521951
9Selenocompound metabolism_Homo sapiens_hsa004502.06076646
10Platelet activation_Homo sapiens_hsa046111.98341659
11African trypanosomiasis_Homo sapiens_hsa051431.95120933
12TGF-beta signaling pathway_Homo sapiens_hsa043501.89820989
13ABC transporters_Homo sapiens_hsa020101.89414908
14Long-term depression_Homo sapiens_hsa047301.87147144
15Arginine and proline metabolism_Homo sapiens_hsa003301.86786965
16Arachidonic acid metabolism_Homo sapiens_hsa005901.86046305
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.79962864
18Histidine metabolism_Homo sapiens_hsa003401.76748662
19Caffeine metabolism_Homo sapiens_hsa002321.76594624
20Circadian rhythm_Homo sapiens_hsa047101.68391517
21Morphine addiction_Homo sapiens_hsa050321.56068448
22Gastric acid secretion_Homo sapiens_hsa049711.53443223
23Vascular smooth muscle contraction_Homo sapiens_hsa042701.53226758
24Phototransduction_Homo sapiens_hsa047441.47899445
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46630470
26Fanconi anemia pathway_Homo sapiens_hsa034601.45285981
27Salivary secretion_Homo sapiens_hsa049701.34766045
28Glutamatergic synapse_Homo sapiens_hsa047241.27357908
29beta-Alanine metabolism_Homo sapiens_hsa004101.26042417
30Arginine biosynthesis_Homo sapiens_hsa002201.22346011
31Serotonergic synapse_Homo sapiens_hsa047261.21077468
32Circadian entrainment_Homo sapiens_hsa047131.20571287
33Chemical carcinogenesis_Homo sapiens_hsa052041.19462596
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.17110264
35Retinol metabolism_Homo sapiens_hsa008301.12004249
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.10750334
37Calcium signaling pathway_Homo sapiens_hsa040201.10267740
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.06622316
39Basal transcription factors_Homo sapiens_hsa030221.06145976
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03015863
41Fatty acid biosynthesis_Homo sapiens_hsa000611.01735272
42GABAergic synapse_Homo sapiens_hsa047270.97212597
43Regulation of autophagy_Homo sapiens_hsa041400.96082001
44Glycosaminoglycan degradation_Homo sapiens_hsa005310.92260369
45Butanoate metabolism_Homo sapiens_hsa006500.91213503
46Ether lipid metabolism_Homo sapiens_hsa005650.87737930
47Insulin resistance_Homo sapiens_hsa049310.87287616
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86823099
49Glycerolipid metabolism_Homo sapiens_hsa005610.85141819
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82547164
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81570906
52Tyrosine metabolism_Homo sapiens_hsa003500.77715663
53Allograft rejection_Homo sapiens_hsa053300.77579583
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77575545
55Pentose phosphate pathway_Homo sapiens_hsa000300.77331361
56Oxytocin signaling pathway_Homo sapiens_hsa049210.76485108
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75567801
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.74134013
59Fat digestion and absorption_Homo sapiens_hsa049750.72644222
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70981273
61Thyroid hormone synthesis_Homo sapiens_hsa049180.68406965
62Insulin secretion_Homo sapiens_hsa049110.67792765
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65062770
64Pancreatic secretion_Homo sapiens_hsa049720.64340685
65Chemokine signaling pathway_Homo sapiens_hsa040620.62228913
66Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60983077
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.59687268
68Bile secretion_Homo sapiens_hsa049760.59193002
69Ovarian steroidogenesis_Homo sapiens_hsa049130.56092392
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54625281
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54173183
72ECM-receptor interaction_Homo sapiens_hsa045120.53940445
73Lysosome_Homo sapiens_hsa041420.53762515
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.53474286
75Sulfur metabolism_Homo sapiens_hsa009200.52857762
76Cholinergic synapse_Homo sapiens_hsa047250.52596077
77PPAR signaling pathway_Homo sapiens_hsa033200.51183456
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49504737
79Vitamin digestion and absorption_Homo sapiens_hsa049770.43892786
80Autoimmune thyroid disease_Homo sapiens_hsa053200.43834719
81Hippo signaling pathway_Homo sapiens_hsa043900.43005814
82Homologous recombination_Homo sapiens_hsa034400.42482832
83Systemic lupus erythematosus_Homo sapiens_hsa053220.42017893
84mTOR signaling pathway_Homo sapiens_hsa041500.40734290
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38017595
86p53 signaling pathway_Homo sapiens_hsa041150.37313399
87Mineral absorption_Homo sapiens_hsa049780.36820595
88TNF signaling pathway_Homo sapiens_hsa046680.36746166
89Alcoholism_Homo sapiens_hsa050340.35134328
90Glutathione metabolism_Homo sapiens_hsa004800.32938234
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32862953
92Taste transduction_Homo sapiens_hsa047420.32050845
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.31557739
94AMPK signaling pathway_Homo sapiens_hsa041520.30333593
95Graft-versus-host disease_Homo sapiens_hsa053320.30255603
96Glucagon signaling pathway_Homo sapiens_hsa049220.28218859
97Peroxisome_Homo sapiens_hsa041460.28045071
98GnRH signaling pathway_Homo sapiens_hsa049120.26583878
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26348185
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26106301

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