OR2B6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histamine transport (GO:0051608)9.92267378
2meiotic chromosome segregation (GO:0045132)9.86319010
3tooth mineralization (GO:0034505)7.87567049
4resolution of meiotic recombination intermediates (GO:0000712)7.83848314
5fatty acid elongation (GO:0030497)7.66465719
6drug transmembrane transport (GO:0006855)7.30678073
7quaternary ammonium group transport (GO:0015697)7.02273250
8neurotransmitter biosynthetic process (GO:0042136)6.98649886
9organic cation transport (GO:0015695)6.97467892
10regulation of immune response to tumor cell (GO:0002837)6.28871088
11regulation of response to tumor cell (GO:0002834)6.28871088
12positive regulation of response to tumor cell (GO:0002836)6.28871088
13positive regulation of immune response to tumor cell (GO:0002839)6.28871088
14positive regulation of meiosis (GO:0045836)6.20718422
15bone trabecula formation (GO:0060346)5.94744274
16exogenous drug catabolic process (GO:0042738)5.94331679
17neurotransmitter metabolic process (GO:0042133)5.79504001
18positive regulation of meiotic cell cycle (GO:0051446)5.75136131
19synaptonemal complex assembly (GO:0007130)5.63048882
20azole transport (GO:0045117)5.45265566
21synaptonemal complex organization (GO:0070193)5.15198930
22positive regulation of hair follicle development (GO:0051798)5.02784015
23positive regulation of hair cycle (GO:0042635)5.02784015
24drug transport (GO:0015893)5.00415114
25histone H3-K36 demethylation (GO:0070544)4.99912498
26pathway-restricted SMAD protein phosphorylation (GO:0060389)4.81736729
27histone-serine phosphorylation (GO:0035404)4.78972196
28positive regulation of mast cell activation (GO:0033005)4.75627818
29positive regulation of protein homodimerization activity (GO:0090073)4.66975511
30rRNA catabolic process (GO:0016075)4.58788441
31drug catabolic process (GO:0042737)4.53130810
32reciprocal meiotic recombination (GO:0007131)4.44050473
33reciprocal DNA recombination (GO:0035825)4.44050473
34regulation of meiosis I (GO:0060631)4.43259237
35epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.27829342
36thrombin receptor signaling pathway (GO:0070493)4.25940985
37negative regulation of telomere maintenance (GO:0032205)4.22063199
38positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.18851999
39protein neddylation (GO:0045116)4.15573219
40chromosome organization involved in meiosis (GO:0070192)4.14073564
41negative regulation of calcium ion transport into cytosol (GO:0010523)4.10282986
42negative regulation of transcription regulatory region DNA binding (GO:2000678)4.07178648
43regulation of mesenchymal cell apoptotic process (GO:2001053)4.01835301
44negative regulation of epidermal cell differentiation (GO:0045605)3.98785391
45cranial suture morphogenesis (GO:0060363)3.96330734
46* detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.95051083
47endothelium development (GO:0003158)3.94438955
48cilium or flagellum-dependent cell motility (GO:0001539)3.88475762
49fatty acid transmembrane transport (GO:1902001)3.83113118
50negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.82948054
51L-phenylalanine catabolic process (GO:0006559)3.64576455
52erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.64576455
53wound healing, spreading of epidermal cells (GO:0035313)3.64069452
54carnitine shuttle (GO:0006853)3.58092611
55histone phosphorylation (GO:0016572)3.54263172
56tyrosine metabolic process (GO:0006570)3.46293018
57behavioral response to nicotine (GO:0035095)3.42894989
58triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.41945039
59protein K6-linked ubiquitination (GO:0085020)3.37907611
60arginine catabolic process (GO:0006527)3.30896887
61leukocyte migration involved in inflammatory response (GO:0002523)3.27801976
62regulation of memory T cell differentiation (GO:0043380)3.21712953
63synapsis (GO:0007129)3.21126041
64negative regulation by host of viral transcription (GO:0043922)3.06606679
65long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.05346766
66L-phenylalanine metabolic process (GO:0006558)3.05282105
67erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.05282105
68regulation of activation of Janus kinase activity (GO:0010533)3.04653421
69regulation of hair follicle development (GO:0051797)3.04550806
70polyamine biosynthetic process (GO:0006596)3.02404668
71secretory granule organization (GO:0033363)2.95512000
72positive regulation of natural killer cell mediated immunity (GO:0002717)2.95197703
73fatty-acyl-CoA biosynthetic process (GO:0046949)2.93244937
74* detection of chemical stimulus involved in sensory perception (GO:0050907)2.84574432
75C4-dicarboxylate transport (GO:0015740)2.84094547
76negative regulation of neural precursor cell proliferation (GO:2000178)2.83762013
77positive regulation of toll-like receptor signaling pathway (GO:0034123)2.82116667
78aromatic amino acid family catabolic process (GO:0009074)2.81965650
79negative regulation of epidermis development (GO:0045683)2.79873669
80negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.77452683
81regulation of energy homeostasis (GO:2000505)2.75785699
82rRNA methylation (GO:0031167)2.73957131
83regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.73830449
84positive regulation of viral genome replication (GO:0045070)2.70619587
85trabecula formation (GO:0060343)2.70398759
86regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.69309631
87regulation of meiosis (GO:0040020)2.68607728
88platelet formation (GO:0030220)2.68428109
89proline biosynthetic process (GO:0006561)2.68180639
90carnitine transmembrane transport (GO:1902603)2.66587582
91outflow tract septum morphogenesis (GO:0003148)2.65599623
92regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.65585724
93regulation of mast cell activation (GO:0033003)2.62891475
94positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.60491832
95lysosome localization (GO:0032418)2.59926787
96platelet aggregation (GO:0070527)2.59107116
97regulation of natural killer cell mediated immunity (GO:0002715)2.58327939
98regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.58327939
99positive regulation of T cell mediated cytotoxicity (GO:0001916)2.56096133
100positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.55994390

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.63855053
2IRF1_19129219_ChIP-ChIP_H3396_Human3.82614240
3ZNF274_21170338_ChIP-Seq_K562_Hela3.58788343
4SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.55757501
5LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.76306545
6GATA1_19941826_ChIP-Seq_K562_Human2.68465517
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.65335168
8LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.41024352
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.40557389
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.36975389
11NANOG_20526341_ChIP-Seq_ESCs_Human2.26037434
12EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.23683462
13SPI1_23127762_ChIP-Seq_K562_Human2.20564850
14GATA2_19941826_ChIP-Seq_K562_Human2.08021414
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00771483
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98850763
17EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.95964603
18E2F1_20622854_ChIP-Seq_HELA_Human1.88785327
19PCGF2_27294783_Chip-Seq_NPCs_Mouse1.81288070
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.80065614
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.75877470
22* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.75372724
23EGR1_23403033_ChIP-Seq_LIVER_Mouse1.74441460
24GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.62325194
25GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.56582847
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56239291
27PHF8_20622854_ChIP-Seq_HELA_Human1.55470007
28EWS_26573619_Chip-Seq_HEK293_Human1.53450737
29SCL_19346495_ChIP-Seq_HPC-7_Human1.53220067
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.52785356
31ETS1_22383799_ChIP-Seq_G1ME_Mouse1.51640009
32GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.50227986
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48339012
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47795830
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47253471
36RAC3_21632823_ChIP-Seq_H3396_Human1.44096663
37* OCT1_27270436_Chip-Seq_PROSTATE_Human1.43583156
38EGR1_19032775_ChIP-ChIP_M12_Human1.43115902
39* BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.39027711
40BCOR_27268052_Chip-Seq_Bcells_Human1.36620088
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33846786
42* FOXH1_21741376_ChIP-Seq_ESCs_Human1.32770841
43P53_21459846_ChIP-Seq_SAOS-2_Human1.31708222
44* NANOG_19829295_ChIP-Seq_ESCs_Human1.30965098
45* SOX2_19829295_ChIP-Seq_ESCs_Human1.30965098
46TP53_22573176_ChIP-Seq_HFKS_Human1.30953684
47ELF1_20517297_ChIP-Seq_JURKAT_Human1.30718212
48GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.30569760
49TAF2_19829295_ChIP-Seq_ESCs_Human1.30304298
50GATA3_21878914_ChIP-Seq_MCF-7_Human1.28798442
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.27851165
52TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27636645
53AR_20517297_ChIP-Seq_VCAP_Human1.25149551
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.24615554
55GATA1_19941827_ChIP-Seq_MEL_Mouse1.21574620
56P68_20966046_ChIP-Seq_HELA_Human1.21151368
57RNF2_27304074_Chip-Seq_NSC_Mouse1.18152409
58JUN_21703547_ChIP-Seq_K562_Human1.15543700
59CEBPB_22108803_ChIP-Seq_LS180_Human1.14927554
60CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14391119
61E2F7_22180533_ChIP-Seq_HELA_Human1.14269579
62LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13387948
63MYB_26560356_Chip-Seq_TH2_Human1.13330550
64IRF8_21731497_ChIP-ChIP_J774_Mouse1.12306386
65GATA3_26560356_Chip-Seq_TH2_Human1.12061865
66E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09611786
67NCOR1_26117541_ChIP-Seq_K562_Human1.08956373
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07759880
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05482352
70* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04887933
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04132876
72TCF4_23295773_ChIP-Seq_U87_Human1.03990870
73GBX2_23144817_ChIP-Seq_PC3_Human1.02063667
74HOXB7_26014856_ChIP-Seq_BT474_Human1.01041545
75OCT4_20526341_ChIP-Seq_ESCs_Human1.00767284
76FOXH1_21741376_ChIP-Seq_EPCs_Human1.00737467
77SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97813605
78* TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97645759
79RBPJ_21746931_ChIP-Seq_IB4_Human0.96967561
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96254504
81* P300_27268052_Chip-Seq_Bcells_Human0.96163733
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95626779
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95308866
84SMAD4_21741376_ChIP-Seq_EPCs_Human0.95172913
85SOX2_21211035_ChIP-Seq_LN229_Human0.94292553
86ERA_21632823_ChIP-Seq_H3396_Human0.93903057
87ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93782294
88NCOR_22424771_ChIP-Seq_293T_Human0.93414183
89GATA6_21074721_ChIP-Seq_CACO-2_Human0.91840284
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.91754245
91* GATA3_26560356_Chip-Seq_TH1_Human0.90996650
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89626290
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89626290
94GATA3_27048872_Chip-Seq_THYMUS_Human0.89138680
95SPI1_20517297_ChIP-Seq_HL60_Human0.88201541
96FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87446734
97GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87431185
98TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.87132867
99CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.86845331
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85767749

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis6.35207398
2MP0003646_muscle_fatigue5.37171510
3MP0005464_abnormal_platelet_physiology4.16739124
4MP0005167_abnormal_blood-brain_barrier3.82144204
5MP0008004_abnormal_stomach_pH3.06967747
6MP0004084_abnormal_cardiac_muscle2.91821549
7MP0004147_increased_porphyrin_level2.72398312
8MP0008872_abnormal_physiological_respon2.65258876
9MP0004130_abnormal_muscle_cell2.64511079
10MP0004381_abnormal_hair_follicle2.60782632
11MP0002837_dystrophic_cardiac_calcinosis2.50295020
12MP0004043_abnormal_pH_regulation2.48806062
13MP0002138_abnormal_hepatobiliary_system2.39403292
14MP0008775_abnormal_heart_ventricle2.32022575
15MP0001919_abnormal_reproductive_system2.22175830
16MP0002160_abnormal_reproductive_system2.19041540
17MP0008875_abnormal_xenobiotic_pharmacok2.10829841
18MP0001873_stomach_inflammation2.05259669
19MP0005645_abnormal_hypothalamus_physiol2.01228657
20MP0004858_abnormal_nervous_system1.95129388
21MP0005410_abnormal_fertilization1.87708862
22MP0006276_abnormal_autonomic_nervous1.85368633
23MP0000372_irregular_coat_pigmentation1.74089740
24MP0001835_abnormal_antigen_presentation1.73183584
25MP0010329_abnormal_lipoprotein_level1.68837527
26MP0003136_yellow_coat_color1.67468726
27MP0005389_reproductive_system_phenotype1.63887360
28MP0003329_amyloid_beta_deposits1.52768984
29MP0005647_abnormal_sex_gland1.52214301
30MP0002163_abnormal_gland_morphology1.50664264
31MP0003566_abnormal_cell_adhesion1.42104653
32MP0002139_abnormal_hepatobiliary_system1.39142658
33MP0004036_abnormal_muscle_relaxation1.36716420
34MP0001664_abnormal_digestion1.33937845
35MP0004484_altered_response_of1.29838465
36MP0009333_abnormal_splenocyte_physiolog1.29095594
37MP0005266_abnormal_metabolism1.27659062
38MP0006054_spinal_hemorrhage1.26893120
39MP0003718_maternal_effect1.26337879
40MP0004883_abnormal_blood_vessel1.26322115
41MP0005085_abnormal_gallbladder_physiolo1.25343223
42MP0003045_fibrosis1.23418705
43MP0001790_abnormal_immune_system1.20493269
44MP0005387_immune_system_phenotype1.20493269
45MP0002733_abnormal_thermal_nociception1.20106169
46MP0004233_abnormal_muscle_weight1.19315674
47MP0005084_abnormal_gallbladder_morpholo1.15305374
48MP0005365_abnormal_bile_salt1.14816015
49MP0001440_abnormal_grooming_behavior1.10730891
50MP0006036_abnormal_mitochondrial_physio1.10593635
51MP0002210_abnormal_sex_determination1.03763929
52MP0000230_abnormal_systemic_arterial1.03210519
53MP0009697_abnormal_copulation1.02434552
54MP0009643_abnormal_urine_homeostasis1.00417990
55MP0008877_abnormal_DNA_methylation0.99874287
56MP0002148_abnormal_hypersensitivity_rea0.97995333
57MP0000858_altered_metastatic_potential0.96830603
58MP0002132_abnormal_respiratory_system0.96250814
59MP0003693_abnormal_embryo_hatching0.94698049
60MP0005360_urolithiasis0.94374287
61MP0003638_abnormal_response/metabolism_0.91786602
62MP0001663_abnormal_digestive_system0.89549195
63MP0003698_abnormal_male_reproductive0.88124837
64MP0005551_abnormal_eye_electrophysiolog0.85083651
65MP0003186_abnormal_redox_activity0.85023695
66MP0005646_abnormal_pituitary_gland0.83633040
67MP0000470_abnormal_stomach_morphology0.82024372
68MP0003195_calcinosis0.81228453
69MP0004145_abnormal_muscle_electrophysio0.80647144
70MP0005448_abnormal_energy_balance0.79629631
71MP0008932_abnormal_embryonic_tissue0.79320886
72MP0009763_increased_sensitivity_to0.74171061
73MP0010307_abnormal_tumor_latency0.73705718
74MP0004957_abnormal_blastocyst_morpholog0.72855362
75MP0009764_decreased_sensitivity_to0.72417185
76MP0001929_abnormal_gametogenesis0.71140431
77MP0003879_abnormal_hair_cell0.69807610
78MP0001800_abnormal_humoral_immune0.68631440
79MP0006035_abnormal_mitochondrial_morpho0.68510250
80MP0001968_abnormal_touch/_nociception0.68164695
81MP0009745_abnormal_behavioral_response0.66206328
82MP0002398_abnormal_bone_marrow0.66169284
83MP0003724_increased_susceptibility_to0.65981481
84MP0008058_abnormal_DNA_repair0.64980613
85MP0000049_abnormal_middle_ear0.64708819
86MP0004142_abnormal_muscle_tone0.64466382
87MP0004215_abnormal_myocardial_fiber0.63868326
88MP0004510_myositis0.63833039
89MP0000747_muscle_weakness0.62812715
90MP0002723_abnormal_immune_serum0.61878075
91MP0001145_abnormal_male_reproductive0.61481550
92MP0002452_abnormal_antigen_presenting0.59807266
93MP0001879_abnormal_lymphatic_vessel0.58301589
94MP0000653_abnormal_sex_gland0.57845499
95MP0003950_abnormal_plasma_membrane0.57399490
96MP0008057_abnormal_DNA_replication0.57271820
97MP0000343_altered_response_to0.57132885
98MP0005671_abnormal_response_to0.56712760
99MP0003252_abnormal_bile_duct0.56502118
100MP0004134_abnormal_chest_morphology0.55327180

Predicted human phenotypes

RankGene SetZ-score
1Unilateral renal agenesis (HP:0000122)8.96545326
2Aplasia/Hypoplasia of the fovea (HP:0008060)7.60413087
3Hypoplasia of the fovea (HP:0007750)7.60413087
4Bilateral microphthalmos (HP:0007633)6.69564480
5Conjugated hyperbilirubinemia (HP:0002908)6.41305744
6Abnormality of the fovea (HP:0000493)6.07313812
7Prolonged bleeding time (HP:0003010)5.50505555
8Aplasia cutis congenita (HP:0001057)5.44831262
9Menorrhagia (HP:0000132)5.20209193
10Aplasia/Hypoplasia of the macula (HP:0008059)4.87947224
11Fused cervical vertebrae (HP:0002949)4.77816412
12Aplasia/Hypoplasia affecting the retina (HP:0008061)4.55706070
133-Methylglutaconic aciduria (HP:0003535)4.45855102
14Increased mean platelet volume (HP:0011877)4.28654633
15Hyperlipoproteinemia (HP:0010980)4.27913078
16Abnormality of the right ventricle (HP:0001707)4.25786607
17Petechiae (HP:0000967)4.20537122
18Abnormality of transition element cation homeostasis (HP:0011030)4.17015961
19Abnormality of the parietal bone (HP:0002696)4.00384611
20Abnormal platelet volume (HP:0011876)3.95007805
21Widely patent fontanelles and sutures (HP:0004492)3.81493904
22Progressive inability to walk (HP:0002505)3.70457531
23Purpura (HP:0000979)3.63168487
24Mixed hearing impairment (HP:0000410)3.41925214
25Epistaxis (HP:0000421)3.23233761
26Abnormality of iron homeostasis (HP:0011031)3.21580229
27Lissencephaly (HP:0001339)3.09612837
28Concave nail (HP:0001598)3.00484443
29CNS hypomyelination (HP:0003429)2.99305150
30Decreased central vision (HP:0007663)2.94321055
31Congenital stationary night blindness (HP:0007642)2.87896321
32Lower limb hyperreflexia (HP:0002395)2.87602371
33Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.86633596
34Abnormal platelet function (HP:0011869)2.77064781
35Impaired platelet aggregation (HP:0003540)2.77064781
36Central scotoma (HP:0000603)2.62775693
37Poikilocytosis (HP:0004447)2.53280478
38Inability to walk (HP:0002540)2.50467711
39Posterior subcapsular cataract (HP:0007787)2.40193600
40Gingival bleeding (HP:0000225)2.39923128
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.36483485
42Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.34153480
43Hip dysplasia (HP:0001385)2.31497146
44Increased serum ferritin (HP:0003281)2.29864467
45Stomatitis (HP:0010280)2.29249499
46Sensorimotor neuropathy (HP:0007141)2.15669704
47Abnormality of alanine metabolism (HP:0010916)2.14323477
48Hyperalaninemia (HP:0003348)2.14323477
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14323477
50Hyperbilirubinemia (HP:0002904)2.13646667
51Vertebral fusion (HP:0002948)2.12644302
52Brushfield spots (HP:0001088)2.12003528
53Arthropathy (HP:0003040)2.08201276
54Large eyes (HP:0001090)2.08028683
55Increased neuronal autofluorescent lipopigment (HP:0002074)2.06095084
56Hepatosplenomegaly (HP:0001433)2.05144965
57Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.01071792
58Acanthocytosis (HP:0001927)2.00347897
59Ulnar deviation of the wrist (HP:0003049)1.99504452
60Wide cranial sutures (HP:0010537)1.98227720
61Tinnitus (HP:0000360)1.96634727
62Cerebral palsy (HP:0100021)1.95855865
63Decreased electroretinogram (ERG) amplitude (HP:0000654)1.95682823
64Tubular atrophy (HP:0000092)1.95576411
65Metabolic alkalosis (HP:0200114)1.91113704
66Clitoromegaly (HP:0000057)1.90552869
67Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90303358
68Elevated erythrocyte sedimentation rate (HP:0003565)1.88612519
69Birth length less than 3rd percentile (HP:0003561)1.87797452
70Tetraplegia (HP:0002445)1.87549131
71Autoimmune thrombocytopenia (HP:0001973)1.85741900
72Severe muscular hypotonia (HP:0006829)1.82711218
73Hyperthyroidism (HP:0000836)1.80235823
74Constricted visual fields (HP:0001133)1.80110405
75Bulbous nose (HP:0000414)1.78564988
76Renal tubular acidosis (HP:0001947)1.77922152
77Hypoplasia of the uterus (HP:0000013)1.77409925
78Abnormality of proline metabolism (HP:0010907)1.76055045
79Hydroxyprolinuria (HP:0003080)1.76055045
80Sprengel anomaly (HP:0000912)1.75361097
81Abnormality of the heme biosynthetic pathway (HP:0010472)1.75340591
82Joint swelling (HP:0001386)1.70861187
83Gaze-evoked nystagmus (HP:0000640)1.70747283
84Hyperglycinuria (HP:0003108)1.70355080
85Increased IgM level (HP:0003496)1.70012912
86Xanthomatosis (HP:0000991)1.66051703
87Decreased circulating renin level (HP:0003351)1.63693774
88Premature skin wrinkling (HP:0100678)1.61233311
89Prominent nose (HP:0000448)1.60413283
90Partial agenesis of the corpus callosum (HP:0001338)1.59478129
91Ventricular fibrillation (HP:0001663)1.58716267
92Abnormality of the renal cortex (HP:0011035)1.57786739
93Autoimmune hemolytic anemia (HP:0001890)1.57497028
94Conical tooth (HP:0000698)1.56771541
95Increased cerebral lipofuscin (HP:0011813)1.56764217
96Triphalangeal thumb (HP:0001199)1.56116174
97Duplicated collecting system (HP:0000081)1.53879499
98Intrahepatic cholestasis (HP:0001406)1.51415751
99Attenuation of retinal blood vessels (HP:0007843)1.50018998
100Renal agenesis (HP:0000104)1.49612013

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK49.77673413
2BMPR25.55181648
3TLK14.27547942
4SIK33.67949692
5SIK23.31214531
6PINK13.13025904
7TAOK32.26721305
8SIK12.17174637
9NEK22.16629854
10MST42.08943677
11ADRBK22.03874939
12MAP3K72.01489757
13ERBB21.80120038
14STK31.75596342
15BTK1.73596520
16MARK31.58698271
17MAP3K111.55054509
18ICK1.53281314
19STK111.44244594
20TEC1.43919147
21EIF2AK11.34177751
22BMX1.27834686
23ACVR1B1.23627621
24EEF2K1.17392144
25MAPKAPK31.15507252
26DAPK21.15186681
27SYK1.09905674
28TIE11.09141734
29PTK2B1.05035435
30MELK0.96247104
31MAPKAPK50.91524378
32ILK0.90363739
33IRAK10.85387718
34PRKAA20.75342041
35FLT30.73657736
36PRKAA10.72159767
37MAP2K10.70109173
38NUAK10.69784022
39FRK0.66298852
40TRPM70.64990809
41CAMK10.64720655
42CHEK20.63743570
43PRKCI0.61165831
44PIK3CG0.58978406
45BCR0.58869225
46TXK0.55075841
47MATK0.54501123
48MAPK130.53531083
49MYLK0.51965629
50JAK30.49831619
51GRK50.49148000
52PLK40.49116007
53MAP3K50.46110797
54STK380.45275573
55ZAK0.44884989
56PAK10.44121662
57ADRBK10.43171624
58BRSK20.42719488
59DAPK10.40977496
60PDPK10.38886762
61PRKACG0.36491097
62PKN10.35669284
63HCK0.34283080
64CAMK40.33962166
65HIPK20.33558272
66GRK10.32060860
67PRKCG0.31885425
68MAP3K10.30842190
69ZAP700.30743519
70BMPR1B0.30602867
71TNK20.28628116
72WNK40.26689145
73CDC42BPA0.26611084
74ATR0.26284486
75PDK10.26164523
76MAP3K20.25021948
77MAPK120.24946800
78PRKCZ0.23144764
79PRKCA0.22891720
80CDK120.22505208
81RPS6KA60.21679460
82RPS6KA50.20564605
83ITK0.20161206
84TTK0.17707008
85PRKCB0.16752656
86MAP3K30.16118035
87RET0.14992443
88KSR20.14861489
89MAPK40.14581339
90CDK40.14226777
91PIK3CA0.13818921
92IGF1R0.13484123
93JAK20.11611515
94MAPK100.11158912
95PLK10.10807067
96CSNK1D0.10298039
97CAMK2A0.10263348
98IKBKB0.10163878
99MAPK110.10137460
100PAK60.09440983

Predicted pathways (KEGG)

RankGene SetZ-score
1* Olfactory transduction_Homo sapiens_hsa047403.79613490
2Fatty acid elongation_Homo sapiens_hsa000623.63254180
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.22605799
4Platelet activation_Homo sapiens_hsa046112.84154290
5Caffeine metabolism_Homo sapiens_hsa002322.63881437
6Nitrogen metabolism_Homo sapiens_hsa009102.41794265
7Choline metabolism in cancer_Homo sapiens_hsa052312.36914633
8Linoleic acid metabolism_Homo sapiens_hsa005912.35647021
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.14722437
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.13588679
11Long-term depression_Homo sapiens_hsa047302.00062010
12Arginine and proline metabolism_Homo sapiens_hsa003301.91746890
13Systemic lupus erythematosus_Homo sapiens_hsa053221.91730490
14African trypanosomiasis_Homo sapiens_hsa051431.91185151
15Arachidonic acid metabolism_Homo sapiens_hsa005901.83944794
16Selenocompound metabolism_Homo sapiens_hsa004501.83321472
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.75599509
18TGF-beta signaling pathway_Homo sapiens_hsa043501.71543507
19ABC transporters_Homo sapiens_hsa020101.51623873
20Circadian rhythm_Homo sapiens_hsa047101.50551127
21Vascular smooth muscle contraction_Homo sapiens_hsa042701.48225858
22Alcoholism_Homo sapiens_hsa050341.36739629
23Carbohydrate digestion and absorption_Homo sapiens_hsa049731.35079756
24Fanconi anemia pathway_Homo sapiens_hsa034601.31694357
25Morphine addiction_Homo sapiens_hsa050321.29051124
26beta-Alanine metabolism_Homo sapiens_hsa004101.24648565
27Serotonergic synapse_Homo sapiens_hsa047261.19469644
28Histidine metabolism_Homo sapiens_hsa003401.15167700
29Salivary secretion_Homo sapiens_hsa049701.15100065
30Basal transcription factors_Homo sapiens_hsa030221.13195938
31Gastric acid secretion_Homo sapiens_hsa049711.13131639
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12236115
33Phototransduction_Homo sapiens_hsa047441.12001992
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10935125
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09737311
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00134361
37Circadian entrainment_Homo sapiens_hsa047130.94184209
38Chemical carcinogenesis_Homo sapiens_hsa052040.93665374
39Allograft rejection_Homo sapiens_hsa053300.90477340
40Pentose phosphate pathway_Homo sapiens_hsa000300.90150999
41Calcium signaling pathway_Homo sapiens_hsa040200.89686910
42Retinol metabolism_Homo sapiens_hsa008300.87915168
43Glycosaminoglycan degradation_Homo sapiens_hsa005310.87297046
44Steroid hormone biosynthesis_Homo sapiens_hsa001400.86368959
45Arginine biosynthesis_Homo sapiens_hsa002200.82393300
46Viral carcinogenesis_Homo sapiens_hsa052030.82170374
47Fat digestion and absorption_Homo sapiens_hsa049750.82125244
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81440946
49Insulin resistance_Homo sapiens_hsa049310.81344204
50Chemokine signaling pathway_Homo sapiens_hsa040620.81254938
51Glycerolipid metabolism_Homo sapiens_hsa005610.80122912
52ECM-receptor interaction_Homo sapiens_hsa045120.78433604
53Hematopoietic cell lineage_Homo sapiens_hsa046400.77949071
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.76165433
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72654249
56Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71815580
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71652793
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70158158
59Glutamatergic synapse_Homo sapiens_hsa047240.68543749
60Homologous recombination_Homo sapiens_hsa034400.68421281
61Regulation of autophagy_Homo sapiens_hsa041400.67261139
62Pancreatic secretion_Homo sapiens_hsa049720.64265694
63mTOR signaling pathway_Homo sapiens_hsa041500.61076088
64Tyrosine metabolism_Homo sapiens_hsa003500.60996678
65Ether lipid metabolism_Homo sapiens_hsa005650.59933869
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58601105
67Oxytocin signaling pathway_Homo sapiens_hsa049210.58296461
68GABAergic synapse_Homo sapiens_hsa047270.57585364
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.57542565
70Autoimmune thyroid disease_Homo sapiens_hsa053200.56996615
71Thyroid hormone synthesis_Homo sapiens_hsa049180.56035606
72p53 signaling pathway_Homo sapiens_hsa041150.51953306
73Butanoate metabolism_Homo sapiens_hsa006500.49306673
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49056540
75B cell receptor signaling pathway_Homo sapiens_hsa046620.48928370
76Primary immunodeficiency_Homo sapiens_hsa053400.48143877
77Glutathione metabolism_Homo sapiens_hsa004800.47000165
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.46379535
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45580313
80Sulfur metabolism_Homo sapiens_hsa009200.44133012
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43691594
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42632966
83One carbon pool by folate_Homo sapiens_hsa006700.42306053
84Non-small cell lung cancer_Homo sapiens_hsa052230.42124982
85VEGF signaling pathway_Homo sapiens_hsa043700.42086991
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41341929
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.39181517
88Graft-versus-host disease_Homo sapiens_hsa053320.39124456
89Bile secretion_Homo sapiens_hsa049760.38936860
90AMPK signaling pathway_Homo sapiens_hsa041520.36036281
91Type II diabetes mellitus_Homo sapiens_hsa049300.35243561
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34543601
93Cholinergic synapse_Homo sapiens_hsa047250.34033023
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34011353
95Insulin secretion_Homo sapiens_hsa049110.33523853
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.33214136
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.32387607
98ErbB signaling pathway_Homo sapiens_hsa040120.30512226
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29144364
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28549503

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