OR2C1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of appetite (GO:0032099)8.61162686
2negative regulation of response to food (GO:0032096)8.61162686
3aggressive behavior (GO:0002118)7.56830416
4production of molecular mediator involved in inflammatory response (GO:0002532)7.29992084
5regulation of transmission of nerve impulse (GO:0051969)7.18855891
6mitochondrial calcium ion transport (GO:0006851)6.60130966
7negative regulation of cAMP-mediated signaling (GO:0043951)6.55954536
8regulation of female receptivity (GO:0045924)6.10598282
9cell wall macromolecule metabolic process (GO:0044036)6.09695917
10glucosamine-containing compound catabolic process (GO:1901072)6.09022083
11rRNA catabolic process (GO:0016075)5.60522500
12regulation of cilium movement (GO:0003352)5.58737844
13regulation of response to food (GO:0032095)5.37924664
14female mating behavior (GO:0060180)5.24995225
15cellular response to leptin stimulus (GO:0044320)5.12447644
16nonmotile primary cilium assembly (GO:0035058)5.10988334
17positive regulation of mitochondrial calcium ion concentration (GO:0051561)5.02269709
18drinking behavior (GO:0042756)4.94592736
19positive regulation of amino acid transport (GO:0051957)4.92913644
20artery smooth muscle contraction (GO:0014824)4.92067706
21mitochondrial calcium ion homeostasis (GO:0051560)4.84488542
22single strand break repair (GO:0000012)4.81073210
23peptidyl-histidine modification (GO:0018202)4.76382881
24purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)4.76339505
25positive regulation of chemokine secretion (GO:0090197)4.72545402
26regulation of appetite (GO:0032098)4.68413328
27regulation of glutamate secretion (GO:0014048)4.62460331
28positive regulation of vascular permeability (GO:0043117)4.52456552
29sodium-independent organic anion transport (GO:0043252)4.47116137
30hyperosmotic salinity response (GO:0042538)4.38585775
31metallo-sulfur cluster assembly (GO:0031163)4.35256013
32iron-sulfur cluster assembly (GO:0016226)4.35256013
33tonic smooth muscle contraction (GO:0014820)4.26641277
34negative regulation of neurological system process (GO:0031645)4.25543062
35deoxyribonucleoside triphosphate metabolic process (GO:0009200)4.18795483
36negative regulation of response to nutrient levels (GO:0032108)4.16330594
37negative regulation of response to extracellular stimulus (GO:0032105)4.16330594
38regulation of chemokine secretion (GO:0090196)4.15206254
39phosphatidylethanolamine metabolic process (GO:0046337)4.14566915
40basic amino acid transport (GO:0015802)4.14141971
41coenzyme catabolic process (GO:0009109)4.13620591
42response to leptin (GO:0044321)4.12965626
43activation of protein kinase A activity (GO:0034199)4.06864071
44cAMP catabolic process (GO:0006198)4.01327922
45phosphatidylethanolamine biosynthetic process (GO:0006646)3.95929173
46vascular smooth muscle contraction (GO:0014829)3.90745789
47maturation of 5.8S rRNA (GO:0000460)3.84882262
48maternal behavior (GO:0042711)3.83976545
49pentose metabolic process (GO:0019321)3.83213883
50positive regulation of fatty acid biosynthetic process (GO:0045723)3.79583142
51aerobic respiration (GO:0009060)3.75857564
52endocrine pancreas development (GO:0031018)3.74435061
53negative regulation of multicellular organism growth (GO:0040015)3.71525519
54negative regulation of digestive system process (GO:0060457)3.68064615
55vasoconstriction (GO:0042310)3.67584779
56DNA ligation (GO:0006266)3.62739276
57response to nitrosative stress (GO:0051409)3.58440404
58positive regulation of calcium ion import (GO:0090280)3.56879272
59nodal signaling pathway (GO:0038092)3.52401713
60positive regulation of systemic arterial blood pressure (GO:0003084)3.50412835
61negative regulation of cell size (GO:0045792)3.43075064
62amino sugar catabolic process (GO:0046348)3.38016609
63positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.37744835
64negative regulation of cytosolic calcium ion concentration (GO:0051481)3.37345449
65negative regulation of lipid catabolic process (GO:0050995)3.33926801
66protein kinase C signaling (GO:0070528)3.33363169
67antigen processing and presentation via MHC class Ib (GO:0002475)3.32094360
68cyclic nucleotide catabolic process (GO:0009214)3.31472182
69parental behavior (GO:0060746)3.31130460
70purine deoxyribonucleotide metabolic process (GO:0009151)3.23479393
71protein palmitoylation (GO:0018345)3.22570745
72negative regulation of necrotic cell death (GO:0060547)3.16944578
73protein localization to microtubule (GO:0035372)3.15497732
74oxidative phosphorylation (GO:0006119)3.05418689
75epithelial cell fate commitment (GO:0072148)3.02451752
76regulation of microtubule-based movement (GO:0060632)2.89749803
77axoneme assembly (GO:0035082)2.88794518
78positive regulation of amine transport (GO:0051954)2.88125837
79regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.87526021
80regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.87526021
81regulation of germinal center formation (GO:0002634)2.81402707
82negative regulation of Notch signaling pathway (GO:0045746)2.81314351
83response to methylmercury (GO:0051597)2.81151889
84receptor recycling (GO:0001881)2.80177717
85neuron fate specification (GO:0048665)2.78980938
86regulation of skeletal muscle contraction (GO:0014819)2.68411875
87negative regulation of translational initiation (GO:0045947)2.68268184
88interferon-gamma production (GO:0032609)2.67234553
89retinal rod cell development (GO:0046548)2.65670966
90glycerophospholipid catabolic process (GO:0046475)2.63850202
91negative regulation of peptide hormone secretion (GO:0090278)2.60942528
92regulation of histone deacetylation (GO:0031063)2.60878162
93positive regulation of histone H3-K4 methylation (GO:0051571)2.59997490
94glucosamine-containing compound metabolic process (GO:1901071)2.59147754
95grooming behavior (GO:0007625)2.58775139
96negative regulation of peptide secretion (GO:0002792)2.57687722
97negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.56600392
98cellular extravasation (GO:0045123)2.53945345
99positive regulation of heat generation (GO:0031652)2.53944384
100regulation of feeding behavior (GO:0060259)2.52903489

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat9.25386985
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.95155850
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.24676345
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.16249423
5TAF15_26573619_Chip-Seq_HEK293_Human2.98380918
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.62870290
7EZH2_22144423_ChIP-Seq_EOC_Human2.60879636
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35364637
9YY1_22570637_ChIP-Seq_MALME-3M_Human2.26437118
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.11000766
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.04963951
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.03891497
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00562189
14RBPJ_22232070_ChIP-Seq_NCS_Mouse1.85759493
15HTT_18923047_ChIP-ChIP_STHdh_Human1.80615001
16ZNF274_21170338_ChIP-Seq_K562_Hela1.68636062
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61274352
18HIF1A_21447827_ChIP-Seq_MCF-7_Human1.57846372
19* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.56289571
20EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.53652491
21ERA_21632823_ChIP-Seq_H3396_Human1.48905846
22CIITA_25753668_ChIP-Seq_RAJI_Human1.48590873
23IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46811597
24TP53_22573176_ChIP-Seq_HFKS_Human1.46232179
25CBP_20019798_ChIP-Seq_JUKART_Human1.45766849
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45766849
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.45096932
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40710602
29ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34610682
30SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33713020
31GATA3_27048872_Chip-Seq_THYMUS_Human1.31801704
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.31435339
33P300_27268052_Chip-Seq_Bcells_Human1.30690749
34E2F1_20622854_ChIP-Seq_HELA_Human1.28667729
35BCAT_22108803_ChIP-Seq_LS180_Human1.26101443
36PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.25761953
37IGF1R_20145208_ChIP-Seq_DFB_Human1.25315460
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23295044
39ERG_20517297_ChIP-Seq_VCAP_Human1.21731324
40STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.20626968
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20199441
42REST_21632747_ChIP-Seq_MESCs_Mouse1.19887384
43ELF1_20517297_ChIP-Seq_JURKAT_Human1.19624700
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18454654
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17516115
46FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15269508
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.14753159
48GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12441878
49BCL6_27268052_Chip-Seq_Bcells_Human1.12279605
50RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12034691
51REST_18959480_ChIP-ChIP_MESCs_Mouse1.09866692
52IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08812532
53KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08313646
54GATA3_26560356_Chip-Seq_TH2_Human1.07808097
55EWS_26573619_Chip-Seq_HEK293_Human1.06966829
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.04747451
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04747451
58FOXH1_21741376_ChIP-Seq_ESCs_Human1.03797751
59PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.03629915
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.02729714
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00798557
62TFEB_21752829_ChIP-Seq_HELA_Human1.00336758
63RBPJ_21746931_ChIP-Seq_IB4_Human0.98654121
64EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97709470
65KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97361162
66KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97361162
67KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97361162
68HNFA_21074721_ChIP-Seq_CACO-2_Human0.95160363
69AR_20517297_ChIP-Seq_VCAP_Human0.95079382
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94443600
71EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94440051
72YY1_21170310_ChIP-Seq_MESCs_Mouse0.94377378
73BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.93882800
74SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91779376
75KLF4_18555785_Chip-Seq_ESCs_Mouse0.89510174
76SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89303469
77FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89251978
78SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89121954
79FOXA1_25552417_ChIP-Seq_VCAP_Human0.89091621
80GATA1_19941826_ChIP-Seq_K562_Human0.87645979
81ELK4_26923725_Chip-Seq_MESODERM_Mouse0.87402761
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86975387
83EST1_17652178_ChIP-ChIP_JURKAT_Human0.86318916
84MAF_26560356_Chip-Seq_TH2_Human0.85994115
85FLI1_21867929_ChIP-Seq_TH2_Mouse0.85724614
86GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.84207031
87GATA6_21074721_ChIP-Seq_CACO-2_Human0.82719634
88POU3F2_20337985_ChIP-ChIP_501MEL_Human0.80623354
89HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.79876131
90NCOR_22424771_ChIP-Seq_293T_Human0.79832366
91SMRT_27268052_Chip-Seq_Bcells_Human0.79699592
92EED_16625203_ChIP-ChIP_MESCs_Mouse0.79370069
93NFYB_21822215_ChIP-Seq_K562_Human0.79053663
94MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.78913829
95KLF4_19829295_ChIP-Seq_ESCs_Human0.78522733
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.78476583
97MYB_26560356_Chip-Seq_TH1_Human0.77987739
98CSB_26484114_Chip-Seq_FIBROBLAST_Human0.76331115
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.75617954
100SOX2_22085726_ChIP-Seq_NPCs_Mouse0.75074393

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol7.66966460
2MP0001984_abnormal_olfaction4.07824361
3MP0009840_abnormal_foam_cell3.57899047
4MP0005670_abnormal_white_adipose3.54991054
5MP0003191_abnormal_cellular_cholesterol3.16306375
6MP0002909_abnormal_adrenal_gland2.86253644
7MP0002653_abnormal_ependyma_morphology2.61378030
8MP0002693_abnormal_pancreas_physiology2.54223262
9MP0005379_endocrine/exocrine_gland_phen2.34688927
10MP0005377_hearing/vestibular/ear_phenot2.23578451
11MP0003878_abnormal_ear_physiology2.23578451
12MP0003122_maternal_imprinting2.12579327
13MP0002102_abnormal_ear_morphology2.12520248
14MP0009278_abnormal_bone_marrow2.08353087
15MP0005671_abnormal_response_to1.93692149
16MP0003011_delayed_dark_adaptation1.84126259
17MP0009046_muscle_twitch1.80694811
18MP0002638_abnormal_pupillary_reflex1.78782891
19MP0002734_abnormal_mechanical_nocicepti1.78060993
20MP0003718_maternal_effect1.77137432
21MP0001970_abnormal_pain_threshold1.74554558
22MP0001764_abnormal_homeostasis1.72004158
23MP0005535_abnormal_body_temperature1.67826353
24MP0003787_abnormal_imprinting1.64821995
25MP0001529_abnormal_vocalization1.64309048
26MP0002837_dystrophic_cardiac_calcinosis1.62436889
27MP0008789_abnormal_olfactory_epithelium1.61114815
28MP0001486_abnormal_startle_reflex1.59613415
29MP0002272_abnormal_nervous_system1.53427687
30MP0005058_abnormal_lysosome_morphology1.50905824
31MP0002332_abnormal_exercise_endurance1.50330910
32MP0004142_abnormal_muscle_tone1.48209998
33MP0008872_abnormal_physiological_respon1.45775697
34MP0005551_abnormal_eye_electrophysiolog1.44223250
35MP0003300_gastrointestinal_ulcer1.43041006
36MP0009115_abnormal_fat_cell1.42833483
37MP0005332_abnormal_amino_acid1.41348914
38MP0008877_abnormal_DNA_methylation1.38469421
39MP0002733_abnormal_thermal_nociception1.37915273
40MP0005257_abnormal_intraocular_pressure1.36023095
41MP0005266_abnormal_metabolism1.34724408
42MP0001944_abnormal_pancreas_morphology1.33361058
43MP0005584_abnormal_enzyme/coenzyme_acti1.32536750
44MP0001270_distended_abdomen1.28752744
45MP0008004_abnormal_stomach_pH1.28483660
46MP0000631_abnormal_neuroendocrine_gland1.27331420
47MP0000013_abnormal_adipose_tissue1.24383204
48MP0002971_abnormal_brown_adipose1.23321821
49MP0003953_abnormal_hormone_level1.22314177
50MP0002163_abnormal_gland_morphology1.19569922
51MP0001968_abnormal_touch/_nociception1.19212455
52MP0005646_abnormal_pituitary_gland1.19096879
53MP0004147_increased_porphyrin_level1.17379310
54MP0002269_muscular_atrophy1.17174246
55MP0001963_abnormal_hearing_physiology1.16336389
56MP0001765_abnormal_ion_homeostasis1.13231911
57MP0002736_abnormal_nociception_after1.09562118
58MP0005636_abnormal_mineral_homeostasis1.07628291
59MP0005448_abnormal_energy_balance1.03846050
60MP0000465_gastrointestinal_hemorrhage1.02261170
61MP0005394_taste/olfaction_phenotype1.02185802
62MP0005499_abnormal_olfactory_system1.02185802
63MP0004270_analgesia1.01394506
64MP0003121_genomic_imprinting1.00600494
65MP0001664_abnormal_digestion1.00360703
66MP0002078_abnormal_glucose_homeostasis0.99253985
67MP0000026_abnormal_inner_ear0.99016810
68MP0002234_abnormal_pharynx_morphology0.97579816
69MP0005376_homeostasis/metabolism_phenot0.95757372
70MP0006036_abnormal_mitochondrial_physio0.90712640
71MP0002938_white_spotting0.90143756
72MP0004133_heterotaxia0.87778151
73MP0004145_abnormal_muscle_electrophysio0.84728645
74MP0005334_abnormal_fat_pad0.84058179
75MP0005253_abnormal_eye_physiology0.83661783
76MP0002877_abnormal_melanocyte_morpholog0.82572927
77MP0003959_abnormal_lean_body0.82504166
78MP0009785_altered_susceptibility_to0.79590052
79MP0004019_abnormal_vitamin_homeostasis0.79317237
80MP0006072_abnormal_retinal_apoptosis0.76685305
81MP0005360_urolithiasis0.75511664
82MP0005451_abnormal_body_composition0.75341947
83MP0009642_abnormal_blood_homeostasis0.74599943
84MP0005666_abnormal_adipose_tissue0.74312521
85MP0004924_abnormal_behavior0.71689523
86MP0005386_behavior/neurological_phenoty0.71689523
87MP0002572_abnormal_emotion/affect_behav0.70326561
88MP0005375_adipose_tissue_phenotype0.68889751
89MP0000639_abnormal_adrenal_gland0.66920023
90MP0006292_abnormal_olfactory_placode0.65585515
91MP0000230_abnormal_systemic_arterial0.64738312
92MP0002118_abnormal_lipid_homeostasis0.62389612
93MP0010155_abnormal_intestine_physiology0.61569375
94MP0005075_abnormal_melanosome_morpholog0.61215399
95MP0000003_abnormal_adipose_tissue0.61109526
96MP0008569_lethality_at_weaning0.60525473
97MP0003763_abnormal_thymus_physiology0.59256859
98MP0001485_abnormal_pinna_reflex0.59203563
99MP0005452_abnormal_adipose_tissue0.58559416
100MP0010386_abnormal_urinary_bladder0.57920755

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)6.39728794
2Hyperphosphatemia (HP:0002905)5.16384117
3Medial flaring of the eyebrow (HP:0010747)5.03743534
4Aplasia/Hypoplasia of the sacrum (HP:0008517)4.97751813
5Septate vagina (HP:0001153)4.89659303
6Rectal fistula (HP:0100590)4.45301051
7Rectovaginal fistula (HP:0000143)4.45301051
8Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.11933162
9Congenital primary aphakia (HP:0007707)4.11444097
10Gait imbalance (HP:0002141)4.07200899
11Unilateral renal agenesis (HP:0000122)3.96739113
12Congenital malformation of the right heart (HP:0011723)3.94238853
13Double outlet right ventricle (HP:0001719)3.94238853
14Vacuolated lymphocytes (HP:0001922)3.79230816
15Intestinal fistula (HP:0100819)3.75367198
16Dysautonomia (HP:0002459)3.69565600
17Vaginal fistula (HP:0004320)3.63450718
18Aplastic anemia (HP:0001915)3.61147771
19Nephrogenic diabetes insipidus (HP:0009806)3.57440854
20Poor speech (HP:0002465)3.53752412
21Metaphyseal dysplasia (HP:0100255)3.53385462
22Hypokinesia (HP:0002375)3.45195420
23Myoglobinuria (HP:0002913)3.43676709
24Rhabdomyolysis (HP:0003201)3.39042192
25Congenital stationary night blindness (HP:0007642)3.37481047
26Polyphagia (HP:0002591)3.26980999
27Abnormal hair whorl (HP:0010721)3.25796940
28Cardiomegaly (HP:0001640)3.23616878
29Growth hormone excess (HP:0000845)3.12563203
303-Methylglutaconic aciduria (HP:0003535)3.07599140
31Poor coordination (HP:0002370)3.06422066
32Orthostatic hypotension (HP:0001278)3.00730316
33Severe combined immunodeficiency (HP:0004430)2.90211402
34Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.89623301
35Abnormality of calcium-phosphate metabolism (HP:0100530)2.88992511
36Abnormality of abdominal situs (HP:0011620)2.85638118
37Abdominal situs inversus (HP:0003363)2.85638118
38Overlapping toe (HP:0001845)2.73872029
39Pigmentary retinal degeneration (HP:0001146)2.73685354
40Inability to walk (HP:0002540)2.71013619
41Vaginal atresia (HP:0000148)2.60178051
42Genital tract atresia (HP:0001827)2.55387054
43Diminished movement (HP:0002374)2.54995261
44Hypercholesterolemia (HP:0003124)2.52570426
45Atrioventricular canal defect (HP:0006695)2.50122182
46Insomnia (HP:0100785)2.46890979
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.34681150
48Abnormality of alanine metabolism (HP:0010916)2.34681150
49Hyperalaninemia (HP:0003348)2.34681150
50Failure to thrive in infancy (HP:0001531)2.34084875
51Acute necrotizing encephalopathy (HP:0006965)2.31476907
52Broad foot (HP:0001769)2.31434981
53Combined immunodeficiency (HP:0005387)2.28599881
54Abnormal autonomic nervous system physiology (HP:0012332)2.28549408
55Hyperglycemia (HP:0003074)2.28408024
56Upper limb muscle weakness (HP:0003484)2.27227110
57Ketosis (HP:0001946)2.23519135
58Hyperkalemia (HP:0002153)2.21673959
59Aplasia/Hypoplasia of the lens (HP:0008063)2.11682606
60Vertebral hypoplasia (HP:0008417)2.11113104
61Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.11113104
62Ketoacidosis (HP:0001993)2.10832793
63Attenuation of retinal blood vessels (HP:0007843)2.07458182
64Aplasia/Hypoplasia involving the vertebral column (HP:0008518)2.07235584
65Truncus arteriosus (HP:0001660)2.05448764
66Anxiety (HP:0000739)2.04391475
67Generalized amyotrophy (HP:0003700)2.02431980
68Intestinal atresia (HP:0011100)1.99821297
69Cerebral edema (HP:0002181)1.99309488
70Abnormal mitochondria in muscle tissue (HP:0008316)1.98734717
71Abnormal albumin level (HP:0012116)1.98548716
72Hypoalbuminemia (HP:0003073)1.98548716
73Epidermoid cyst (HP:0200040)1.97581529
74Chronic diarrhea (HP:0002028)1.95958169
75Gaze-evoked nystagmus (HP:0000640)1.95057586
76Bicornuate uterus (HP:0000813)1.95039712
77Left ventricular hypertrophy (HP:0001712)1.89458116
78Cerebral hypomyelination (HP:0006808)1.88771010
79Abnormality of the parietal bone (HP:0002696)1.87992702
80Abnormality of the aortic arch (HP:0012303)1.82970052
81Increased CSF protein (HP:0002922)1.82643542
82Agitation (HP:0000713)1.81413915
83Aplasia/Hypoplasia of the fovea (HP:0008060)1.80783117
84Hypoplasia of the fovea (HP:0007750)1.80783117
85Acute encephalopathy (HP:0006846)1.80390746
86Joint swelling (HP:0001386)1.80025453
87Abolished electroretinogram (ERG) (HP:0000550)1.78241035
88Long foot (HP:0001833)1.75822598
89Specific learning disability (HP:0001328)1.74863280
90Flat cornea (HP:0007720)1.74733346
91Hypercalciuria (HP:0002150)1.74186187
92Hydroureter (HP:0000072)1.74124311
93Limb-girdle muscle atrophy (HP:0003797)1.73708778
94Oligomenorrhea (HP:0000876)1.73097358
95Elfin facies (HP:0004428)1.71606648
96Limb ataxia (HP:0002070)1.70920252
97Progressive macrocephaly (HP:0004481)1.68858326
98Hypoproteinemia (HP:0003075)1.68776922
99Hyperammonemia (HP:0001987)1.66010125
100Beaking of vertebral bodies (HP:0004568)1.65520981

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K29.22310788
2LATS16.02987425
3MAP3K114.60718095
4MAP4K14.08054236
5NUAK13.35228417
6TXK3.08074005
7MAP3K122.51703151
8DYRK1B2.47770009
9DAPK22.34132748
10MAP2K62.19266229
11SCYL22.10551279
12BCKDK1.96452133
13PASK1.88139368
14MAP3K131.69888370
15TAOK31.66681398
16ZAK1.55012065
17NLK1.45001274
18STK31.26743969
19PIK3CG1.25433590
20CDK31.20741391
21WNK41.14886555
22RIPK11.05825555
23MAP3K71.04984347
24MAP3K91.01504504
25MAP3K10.93383457
26MAPKAPK30.93382786
27STK390.90429429
28CDK120.87260021
29GRK10.82656638
30ARAF0.80483490
31IKBKE0.78623604
32CASK0.77857914
33NME10.77046050
34CAMKK10.76820779
35PAK60.76057243
36MAP2K20.73719377
37PRKD20.64143032
38NEK10.62742391
39MAP2K40.57192118
40CSF1R0.56837998
41MAP3K50.56152791
42CAMK10.55099129
43KDR0.51828528
44VRK20.51823370
45IKBKB0.49538305
46MAP2K30.49063913
47CDC42BPA0.48586653
48ADRBK10.48059876
49TYRO30.47167625
50ABL20.45515984
51TNK20.44716424
52PAK30.43584692
53TAOK20.41070448
54ADRBK20.39005549
55PKN10.37244617
56NTRK20.35978699
57LRRK20.35674766
58VRK10.35506109
59RPS6KA60.33652196
60LIMK10.32801405
61PHKG20.31904783
62PHKG10.31904783
63PRKG10.31576335
64BTK0.31400656
65STK40.31239945
66RPS6KC10.31075415
67RPS6KL10.31075415
68NEK20.29558735
69PRKCQ0.28574458
70PRKAA20.27843437
71MAP3K30.27726441
72MAPK150.27554672
73MAP3K40.27448089
74JAK30.27192735
75BMPR1B0.27140467
76DAPK10.27032578
77CDK80.26758707
78CHEK20.26312133
79INSRR0.25891045
80CAMKK20.25748112
81PLK10.22593470
82FYN0.22590740
83CAMK40.22500335
84CAMK2D0.21736302
85TLK10.21561972
86DYRK1A0.21377711
87GRK60.20328842
88UHMK10.20032522
89STK380.17861348
90NEK90.16334219
91BRAF0.15337258
92PIM20.14877798
93OBSCN0.14822463
94SYK0.14504915
95HIPK20.13180892
96PRKCG0.12039622
97PRKACA0.11376664
98FGR0.10503095
99RAF10.10260277
100JAK20.09721283

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.44251408
2Pentose phosphate pathway_Homo sapiens_hsa000303.52882838
3Phototransduction_Homo sapiens_hsa047443.45773038
4Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.02212730
5Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.78640846
6Primary immunodeficiency_Homo sapiens_hsa053402.20575110
7Type I diabetes mellitus_Homo sapiens_hsa049402.19254219
8Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.18751669
9RNA polymerase_Homo sapiens_hsa030201.95174301
10RNA degradation_Homo sapiens_hsa030181.93557514
11Fatty acid elongation_Homo sapiens_hsa000621.90902586
12Arginine and proline metabolism_Homo sapiens_hsa003301.85845927
13Morphine addiction_Homo sapiens_hsa050321.82578537
14Oxidative phosphorylation_Homo sapiens_hsa001901.80070642
15Salivary secretion_Homo sapiens_hsa049701.76935089
16Purine metabolism_Homo sapiens_hsa002301.74880918
17Selenocompound metabolism_Homo sapiens_hsa004501.70946063
18Arginine biosynthesis_Homo sapiens_hsa002201.67238158
19Renin secretion_Homo sapiens_hsa049241.63629402
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61078277
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.58942204
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.57994418
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56550226
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.55608109
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.44454078
26Collecting duct acid secretion_Homo sapiens_hsa049661.43501021
27Sphingolipid metabolism_Homo sapiens_hsa006001.36689673
28Galactose metabolism_Homo sapiens_hsa000521.34166738
29* Olfactory transduction_Homo sapiens_hsa047401.14880549
30Lysosome_Homo sapiens_hsa041421.05157553
31Cardiac muscle contraction_Homo sapiens_hsa042601.03240029
32SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97955397
33Rheumatoid arthritis_Homo sapiens_hsa053230.95060463
34Ribosome_Homo sapiens_hsa030100.92598308
35Protein export_Homo sapiens_hsa030600.90195481
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89998237
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88715238
38Parkinsons disease_Homo sapiens_hsa050120.87579519
39Pyrimidine metabolism_Homo sapiens_hsa002400.86729562
40Phenylalanine metabolism_Homo sapiens_hsa003600.84597203
41Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84202448
42Oocyte meiosis_Homo sapiens_hsa041140.83868558
43Nicotine addiction_Homo sapiens_hsa050330.83742358
44Propanoate metabolism_Homo sapiens_hsa006400.80442904
45Dopaminergic synapse_Homo sapiens_hsa047280.78382241
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77969309
47GABAergic synapse_Homo sapiens_hsa047270.75304235
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75299142
49Peroxisome_Homo sapiens_hsa041460.74462472
50Carbon metabolism_Homo sapiens_hsa012000.74260668
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71417735
52Nitrogen metabolism_Homo sapiens_hsa009100.67983312
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.67707660
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67333684
55Malaria_Homo sapiens_hsa051440.65771186
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.63751712
57Fatty acid metabolism_Homo sapiens_hsa012120.62826566
58Insulin secretion_Homo sapiens_hsa049110.62458224
59Glycerophospholipid metabolism_Homo sapiens_hsa005640.60936427
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60550077
61beta-Alanine metabolism_Homo sapiens_hsa004100.60359279
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57518551
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57191459
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.56415519
65Huntingtons disease_Homo sapiens_hsa050160.56396257
66Ovarian steroidogenesis_Homo sapiens_hsa049130.56234044
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56181462
68Phagosome_Homo sapiens_hsa041450.56109485
69Vibrio cholerae infection_Homo sapiens_hsa051100.56041070
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55867149
71Tyrosine metabolism_Homo sapiens_hsa003500.55013188
72Ether lipid metabolism_Homo sapiens_hsa005650.54931163
73Tryptophan metabolism_Homo sapiens_hsa003800.54125272
74Salmonella infection_Homo sapiens_hsa051320.53456123
75T cell receptor signaling pathway_Homo sapiens_hsa046600.53131391
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52157598
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50629271
78Cocaine addiction_Homo sapiens_hsa050300.50362097
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.50033783
80Metabolic pathways_Homo sapiens_hsa011000.49079707
81Serotonergic synapse_Homo sapiens_hsa047260.48942970
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48850079
83cAMP signaling pathway_Homo sapiens_hsa040240.47724304
84Circadian entrainment_Homo sapiens_hsa047130.47661580
85Arachidonic acid metabolism_Homo sapiens_hsa005900.47027929
86Notch signaling pathway_Homo sapiens_hsa043300.46254906
87Dilated cardiomyopathy_Homo sapiens_hsa054140.43191241
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42276310
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41823313
90Retinol metabolism_Homo sapiens_hsa008300.41587647
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40734619
92Fructose and mannose metabolism_Homo sapiens_hsa000510.39159411
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.38504908
94Hematopoietic cell lineage_Homo sapiens_hsa046400.38124401
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38037137
96Starch and sucrose metabolism_Homo sapiens_hsa005000.37665298
97Synaptic vesicle cycle_Homo sapiens_hsa047210.35945497
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33864433
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32738168
100Alzheimers disease_Homo sapiens_hsa050100.30964790

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