OR2C3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to muscle activity (GO:0014850)4.94053229
2regulation of oxidative stress-induced neuron death (GO:1903203)4.85252403
3positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.64265067
4negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.49730785
5positive regulation of catecholamine secretion (GO:0033605)4.35816308
6histone H3-K36 demethylation (GO:0070544)4.00624859
7regulation of phosphoprotein phosphatase activity (GO:0043666)3.87477534
8protein localization to cell surface (GO:0034394)3.83142693
9barbed-end actin filament capping (GO:0051016)3.74574517
10COPII vesicle coating (GO:0048208)3.65755173
11relaxation of smooth muscle (GO:0044557)3.61885000
12coenzyme catabolic process (GO:0009109)3.57933392
13ADP metabolic process (GO:0046031)3.54804402
14muscle cell cellular homeostasis (GO:0046716)3.54029617
15regulation of autophagic vacuole assembly (GO:2000785)3.50737552
16myofibril assembly (GO:0030239)3.47363201
17regulation of myoblast differentiation (GO:0045661)3.46831624
18cytoplasmic mRNA processing body assembly (GO:0033962)3.44719282
19cGMP-mediated signaling (GO:0019934)3.44312803
20negative regulation of striated muscle cell apoptotic process (GO:0010664)3.38106529
21regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.27144357
22negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.21364059
23activation of protein kinase B activity (GO:0032148)3.19211798
24negative regulation of homotypic cell-cell adhesion (GO:0034111)3.15622992
25nucleoside diphosphate biosynthetic process (GO:0009133)3.15094209
26receptor recycling (GO:0001881)3.09768959
27muscle filament sliding (GO:0030049)3.08810363
28actin-myosin filament sliding (GO:0033275)3.08810363
29actin-mediated cell contraction (GO:0070252)3.06198746
30paraxial mesoderm development (GO:0048339)3.05681577
31regulation of transforming growth factor beta2 production (GO:0032909)2.99159827
32sarcomere organization (GO:0045214)2.95850218
33negative regulation of response to reactive oxygen species (GO:1901032)2.95298151
34regulation of vacuole organization (GO:0044088)2.93755027
35regulation of hydrogen peroxide-induced cell death (GO:1903205)2.88671236
36retina vasculature morphogenesis in camera-type eye (GO:0061299)2.88007613
37cellular response to osmotic stress (GO:0071470)2.84688523
38positive regulation of myoblast differentiation (GO:0045663)2.84610362
39regulation of NFAT protein import into nucleus (GO:0051532)2.84296883
40peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.82197889
41embryonic process involved in female pregnancy (GO:0060136)2.82149559
42protein retention in ER lumen (GO:0006621)2.81170618
43actin filament-based movement (GO:0030048)2.80776472
44regulation of skeletal muscle fiber development (GO:0048742)2.76347405
45positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.72079481
46cortical actin cytoskeleton organization (GO:0030866)2.70666546
47dicarboxylic acid biosynthetic process (GO:0043650)2.70591445
48TOR signaling (GO:0031929)2.70499369
49maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.69422721
50focal adhesion assembly (GO:0048041)2.68255313
51cell-substrate adherens junction assembly (GO:0007045)2.68255313
52cell adhesion mediated by integrin (GO:0033627)2.68068635
53negative regulation of fatty acid transport (GO:2000192)2.55216336
54regulation of phospholipase A2 activity (GO:0032429)2.53251798
55AMP metabolic process (GO:0046033)2.52429437
56Golgi transport vesicle coating (GO:0048200)2.51315387
57COPI coating of Golgi vesicle (GO:0048205)2.51315387
58peptidyl-threonine modification (GO:0018210)2.50922612
59regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.50873572
60diacylglycerol metabolic process (GO:0046339)2.47133996
61histone lysine demethylation (GO:0070076)2.46798102
62cellular zinc ion homeostasis (GO:0006882)2.46534205
63membrane tubulation (GO:0097320)2.44249060
64regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.42786571
65regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.41696582
66chondroitin sulfate catabolic process (GO:0030207)2.41647922
67protein localization to endosome (GO:0036010)2.40906990
68motile cilium assembly (GO:0044458)2.40842396
69negative regulation of norepinephrine secretion (GO:0010700)2.39451158
70adherens junction assembly (GO:0034333)2.39227742
71positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.38346679
72cytoskeletal anchoring at plasma membrane (GO:0007016)2.37407131
73regulation of synaptic vesicle transport (GO:1902803)2.35607185
74relaxation of muscle (GO:0090075)2.34144782
75endoplasmic reticulum organization (GO:0007029)2.34038349
76regulation of oxidative phosphorylation (GO:0002082)2.33950852
77definitive hemopoiesis (GO:0060216)2.33479293
78cortical cytoskeleton organization (GO:0030865)2.33004038
79cell-substrate junction assembly (GO:0007044)2.32728844
80cardiac muscle hypertrophy (GO:0003300)2.32112504
81polyamine biosynthetic process (GO:0006596)2.31519429
82histone demethylation (GO:0016577)2.31174389
83retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.31142705
84glycogen metabolic process (GO:0005977)2.30862521
85vesicle coating (GO:0006901)2.30333808
86nuclear pore complex assembly (GO:0051292)2.29587378
87glucan metabolic process (GO:0044042)2.29152325
88cellular glucan metabolic process (GO:0006073)2.29152325
89muscle fiber development (GO:0048747)2.27069718
90glutamine family amino acid catabolic process (GO:0009065)2.26199412
91regulation of cAMP-dependent protein kinase activity (GO:2000479)2.26119698
92cardiac myofibril assembly (GO:0055003)2.25968890
93negative regulation of muscle cell apoptotic process (GO:0010656)2.25945237
94histone H3-K9 demethylation (GO:0033169)2.24933067
95positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)2.23232183
96peptidyl-lysine dimethylation (GO:0018027)2.22323606
97regulation of ARF GTPase activity (GO:0032312)2.22004257
98iron ion import (GO:0097286)2.21924265
99regulation of relaxation of muscle (GO:1901077)2.21676603
100retrograde transport, endosome to Golgi (GO:0042147)2.20806894

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.77930293
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.29649157
3ESR1_20079471_ChIP-ChIP_T-47D_Human3.85082252
4IGF1R_20145208_ChIP-Seq_DFB_Human3.31120699
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.28133563
6WT1_19549856_ChIP-ChIP_CCG9911_Human2.97961356
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.78009442
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.77512172
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.71049878
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.68106027
11GBX2_23144817_ChIP-Seq_PC3_Human2.58441965
12CLOCK_20551151_ChIP-Seq_293T_Human2.51823645
13GATA1_22025678_ChIP-Seq_K562_Human2.39865871
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.31124592
15AR_21572438_ChIP-Seq_LNCaP_Human2.18077320
16EP300_21415370_ChIP-Seq_HL-1_Mouse1.96722281
17ZNF217_24962896_ChIP-Seq_MCF-7_Human1.92614488
18ZNF263_19887448_ChIP-Seq_K562_Human1.89790861
19SALL4_18804426_ChIP-ChIP_XEN_Mouse1.83909438
20* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.83652300
21NRF2_20460467_ChIP-Seq_MEFs_Mouse1.72794783
22NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.72794783
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67383794
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.64879453
25GATA2_21666600_ChIP-Seq_HMVEC_Human1.63893316
26AHR_22903824_ChIP-Seq_MCF-7_Human1.54460178
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51484393
28ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.51240033
29SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.48595247
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41859584
31CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.40980404
32ARNT_22903824_ChIP-Seq_MCF-7_Human1.39207140
33SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.37509125
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36503753
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.35712646
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35141098
37SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.33084886
38BRD4_25478319_ChIP-Seq_HGPS_Human1.32865786
39TBX20_22080862_ChIP-Seq_HEART_Mouse1.32839320
40TBX20_22328084_ChIP-Seq_HEART_Mouse1.32839320
41CJUN_26792858_Chip-Seq_BT549_Human1.32507205
42PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.31533850
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.30915463
44FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26523047
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24788238
46YAP1_20516196_ChIP-Seq_MESCs_Mouse1.24765059
47SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.21080023
48SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.21080023
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20739422
50PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20071725
51HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20011370
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18782922
53CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15947494
54TP53_18474530_ChIP-ChIP_U2OS_Human1.14755912
55ER_23166858_ChIP-Seq_MCF-7_Human1.14615212
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14404241
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11920194
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11653430
59RXR_22108803_ChIP-Seq_LS180_Human1.11156178
60SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10012319
61TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.09485975
62SMAD4_21799915_ChIP-Seq_A2780_Human1.06637238
63MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.05513641
64PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05229989
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05077245
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01363867
67CHD1_26751641_Chip-Seq_LNCaP_Human1.01153157
68CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00832927
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98339187
70GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98271033
71GATA2_19941826_ChIP-Seq_K562_Human0.96863927
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95938138
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94965461
74AR_21909140_ChIP-Seq_LNCAP_Human0.94294629
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93957465
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93091778
77TCF4_18268006_ChIP-ChIP_LS174T_Human0.92902819
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92597572
79NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90949557
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90786911
81TP53_16413492_ChIP-PET_HCT116_Human0.89928279
82NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89333182
83FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89066280
84SPI1_23127762_ChIP-Seq_K562_Human0.88167510
85FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87380311
86FOXO3_23340844_ChIP-Seq_DLD1_Human0.87252538
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86707254
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85737007
89KDM2B_26808549_Chip-Seq_DND41_Human0.84990843
90POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83770189
91LXR_22158963_ChIP-Seq_LIVER_Mouse0.83023603
92ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.81652399
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.80648490
94RBPJ_22232070_ChIP-Seq_NCS_Mouse0.78511744
95WDR5_24793694_ChIP-Seq_LNCAP_Human0.78297211
96NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78266792
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.77982821
98KDM2B_26808549_Chip-Seq_K562_Human0.76993738
99TP63_23658742_ChIP-Seq_EP156T_Human0.76733114
100UBF1/2_26484160_Chip-Seq_HMECs_Human0.76614619

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH3.80562179
2MP0004084_abnormal_cardiac_muscle3.69398744
3MP0004272_abnormal_basement_membrane3.52645345
4MP0000749_muscle_degeneration3.50072022
5MP0005451_abnormal_body_composition2.99260834
6MP0010368_abnormal_lymphatic_system2.88489649
7MP0009697_abnormal_copulation2.56543074
8MP0004036_abnormal_muscle_relaxation2.56242086
9MP0004233_abnormal_muscle_weight2.37587837
10MP0005248_abnormal_Harderian_gland2.28042464
11MP0002877_abnormal_melanocyte_morpholog2.24462412
12MP0003315_abnormal_perineum_morphology2.23521994
13MP0005058_abnormal_lysosome_morphology2.17733256
14MP0010234_abnormal_vibrissa_follicle2.13470537
15MP0008438_abnormal_cutaneous_collagen2.09083291
16MP0005409_darkened_coat_color2.05447560
17MP0005187_abnormal_penis_morphology2.05269968
18MP0001849_ear_inflammation2.03066226
19MP0003705_abnormal_hypodermis_morpholog1.97951059
20MP0002269_muscular_atrophy1.93044729
21MP0000465_gastrointestinal_hemorrhage1.91708026
22MP0009780_abnormal_chondrocyte_physiolo1.89736372
23MP0003566_abnormal_cell_adhesion1.84209360
24MP0003385_abnormal_body_wall1.82173400
25MP0004087_abnormal_muscle_fiber1.80024474
26MP0000747_muscle_weakness1.79530466
27MP0003828_pulmonary_edema1.74780542
28MP0003091_abnormal_cell_migration1.73926661
29MP0000537_abnormal_urethra_morphology1.71423556
30MP0000759_abnormal_skeletal_muscle1.71188553
31MP0004484_altered_response_of1.71071465
32MP0000751_myopathy1.65783221
33MP0003656_abnormal_erythrocyte_physiolo1.62761619
34MP0005330_cardiomyopathy1.60299695
35MP0006138_congestive_heart_failure1.56204902
36MP0001661_extended_life_span1.56197658
37MP0003806_abnormal_nucleotide_metabolis1.51539778
38MP0002108_abnormal_muscle_morphology1.51379671
39MP0002132_abnormal_respiratory_system1.50879705
40MP0002009_preneoplasia1.48641818
41MP0002127_abnormal_cardiovascular_syste1.48179388
42MP0003868_abnormal_feces_composition1.46254713
43MP0005620_abnormal_muscle_contractility1.44923577
44MP0003300_gastrointestinal_ulcer1.43251683
45MP0005623_abnormal_meninges_morphology1.41898132
46MP0010630_abnormal_cardiac_muscle1.38685040
47MP0004264_abnormal_extraembryonic_tissu1.37747524
48MP0010352_gastrointestinal_tract_polyps1.35318252
49MP0003221_abnormal_cardiomyocyte_apopto1.30568846
50MP0000013_abnormal_adipose_tissue1.26509962
51MP0000733_abnormal_muscle_development1.25295096
52MP0001879_abnormal_lymphatic_vessel1.19127539
53MP0001915_intracranial_hemorrhage1.16773853
54MP0005464_abnormal_platelet_physiology1.14926845
55MP0001299_abnormal_eye_distance/1.09634494
56MP0005275_abnormal_skin_tensile1.08220609
57MP0004215_abnormal_myocardial_fiber1.04955390
58MP0000343_altered_response_to1.03768774
59MP0002972_abnormal_cardiac_muscle1.03456811
60MP0005385_cardiovascular_system_phenoty0.99768080
61MP0001544_abnormal_cardiovascular_syste0.99768080
62MP0000767_abnormal_smooth_muscle0.97425947
63MP0004859_abnormal_synaptic_plasticity0.96029787
64MP0009840_abnormal_foam_cell0.95398978
65MP0005167_abnormal_blood-brain_barrier0.93707598
66MP0003632_abnormal_nervous_system0.91847874
67MP0000920_abnormal_myelination0.91185175
68MP0005369_muscle_phenotype0.89309745
69MP0001984_abnormal_olfaction0.88172018
70MP0005394_taste/olfaction_phenotype0.87972576
71MP0005499_abnormal_olfactory_system0.87972576
72MP0001529_abnormal_vocalization0.87685190
73MP0005410_abnormal_fertilization0.85855722
74MP0008775_abnormal_heart_ventricle0.85782734
75MP0002160_abnormal_reproductive_system0.82837285
76MP0002086_abnormal_extraembryonic_tissu0.81299488
77MP0003136_yellow_coat_color0.80688819
78MP0002128_abnormal_blood_circulation0.80410882
79MP0003935_abnormal_craniofacial_develop0.80264768
80MP0001270_distended_abdomen0.79401284
81MP0002106_abnormal_muscle_physiology0.77856764
82MP0002998_abnormal_bone_remodeling0.75686457
83MP0005621_abnormal_cell_physiology0.75324184
84MP0002332_abnormal_exercise_endurance0.75082452
85MP0005257_abnormal_intraocular_pressure0.74426376
86MP0004270_analgesia0.73671365
87MP0003941_abnormal_skin_development0.70971328
88MP0005388_respiratory_system_phenotype0.68261184
89MP0002133_abnormal_respiratory_system0.68261184
90MP0005595_abnormal_vascular_smooth0.67670699
91MP0002233_abnormal_nose_morphology0.67645522
92MP0004782_abnormal_surfactant_physiolog0.67606390
93MP0002896_abnormal_bone_mineralization0.66828202
94MP0006054_spinal_hemorrhage0.65888489
95MP0005076_abnormal_cell_differentiation0.64917300
96MP0003631_nervous_system_phenotype0.64432358
97MP0003950_abnormal_plasma_membrane0.62816976
98MP0001958_emphysema0.62782740
99MP0001614_abnormal_blood_vessel0.62136190
100MP0000750_abnormal_muscle_regeneration0.61840245

Predicted human phenotypes

RankGene SetZ-score
1Hyporeflexia of lower limbs (HP:0002600)4.69567741
2Exercise-induced myalgia (HP:0003738)4.18477575
3Exercise-induced muscle cramps (HP:0003710)4.09715982
4Centrally nucleated skeletal muscle fibers (HP:0003687)4.08343786
5Scapular winging (HP:0003691)3.97085337
6Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.54806890
7Increased variability in muscle fiber diameter (HP:0003557)3.50885268
8Resting tremor (HP:0002322)3.46242919
9Spinal rigidity (HP:0003306)3.44720677
10Rimmed vacuoles (HP:0003805)3.36865192
11Abnormality of the shoulder girdle musculature (HP:0001435)3.31607065
12Aortic aneurysm (HP:0004942)3.26568753
13Abnormality of skeletal muscle fiber size (HP:0012084)3.23055053
14Abnormality of the columella (HP:0009929)3.19217763
15EMG: myopathic abnormalities (HP:0003458)3.15363811
16Abnormality of the calf musculature (HP:0001430)3.02149754
17Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.99562531
18Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.97120031
19Abnormality of the intrinsic pathway (HP:0010989)2.93923547
20Muscle fiber inclusion bodies (HP:0100299)2.90222717
21Urinary urgency (HP:0000012)2.90089424
22Mitral stenosis (HP:0001718)2.85517981
23Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.80799732
24Difficulty running (HP:0009046)2.77487106
25Asymmetry of the thorax (HP:0001555)2.73393246
26Menorrhagia (HP:0000132)2.70571925
27Reduced antithrombin III activity (HP:0001976)2.64921678
28Papillary thyroid carcinoma (HP:0002895)2.63757609
29Right ventricular cardiomyopathy (HP:0011663)2.53005774
30Aortic dissection (HP:0002647)2.49025887
31Abnormality of the frontal sinuses (HP:0002687)2.47967253
32Syringomyelia (HP:0003396)2.42185018
33Spinal cord lesions (HP:0100561)2.42185018
34Neck muscle weakness (HP:0000467)2.39159063
35Increased mean platelet volume (HP:0011877)2.35248023
36Termporal pattern (HP:0011008)2.35130639
37Insidious onset (HP:0003587)2.35130639
38Arterial tortuosity (HP:0005116)2.26093741
39Thoracic kyphosis (HP:0002942)2.25903535
40Foot dorsiflexor weakness (HP:0009027)2.24226356
41Myoglobinuria (HP:0002913)2.23959890
42Proximal amyotrophy (HP:0007126)2.23591110
43Steppage gait (HP:0003376)2.23551497
44Hypoplasia of the iris (HP:0007676)2.19954541
45Frequent falls (HP:0002359)2.19499970
46Abnormality of the common coagulation pathway (HP:0010990)2.16770906
47Scanning speech (HP:0002168)2.16768362
48Muscular dystrophy (HP:0003560)2.15686479
49Premature rupture of membranes (HP:0001788)2.14886186
50Protrusio acetabuli (HP:0003179)2.12915730
51Ankyloglossia (HP:0010296)2.12345294
52Back pain (HP:0003418)2.11613612
53Deep venous thrombosis (HP:0002625)2.10747322
54Abnormality of the foot musculature (HP:0001436)2.08015063
55Clumsiness (HP:0002312)2.07494037
56Rhabdomyolysis (HP:0003201)2.06688136
57Abnormal platelet volume (HP:0011876)2.06301846
58Sudden death (HP:0001699)2.04615284
59Vascular tortuosity (HP:0004948)2.03213874
60Atonic seizures (HP:0010819)2.02959929
61Calf muscle hypertrophy (HP:0008981)2.01868271
62Capillary hemangiomas (HP:0005306)2.01006545
63Postural instability (HP:0002172)1.99164701
64Nemaline bodies (HP:0003798)1.97852069
65Subaortic stenosis (HP:0001682)1.97484059
66Abnormality of the left ventricular outflow tract (HP:0011103)1.97484059
67Limb-girdle muscle atrophy (HP:0003797)1.96666855
68Abnormality of the lumbar spine (HP:0100712)1.95842305
69Muscle fiber splitting (HP:0003555)1.95349794
70Eosinophilia (HP:0001880)1.94094657
71Malignant hyperthermia (HP:0002047)1.93602673
72Abnormality of the thoracic spine (HP:0100711)1.90651602
73Muscle hypertrophy of the lower extremities (HP:0008968)1.90466035
74Type 1 muscle fiber predominance (HP:0003803)1.90169578
75Thyroid carcinoma (HP:0002890)1.87657639
76Distal arthrogryposis (HP:0005684)1.85955888
77Pelvic girdle muscle weakness (HP:0003749)1.85741214
78Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.84745427
79Mitral valve prolapse (HP:0001634)1.80358272
80Self-mutilation (HP:0000742)1.80009558
81Cubitus valgus (HP:0002967)1.77582622
82Abnormality of the musculature of the pelvis (HP:0001469)1.76876957
83Abnormality of the hip-girdle musculature (HP:0001445)1.76876957
84Difficulty walking (HP:0002355)1.76210942
85Small epiphyses (HP:0010585)1.75486821
86Hammertoe (HP:0001765)1.74174650
87Bulbar palsy (HP:0001283)1.73524149
88Ventricular fibrillation (HP:0001663)1.73062590
89Aplasia cutis congenita (HP:0001057)1.72867766
90Hepatoblastoma (HP:0002884)1.72431113
91Cerebral aneurysm (HP:0004944)1.72343080
92Abnormality of pain sensation (HP:0010832)1.70930489
93Impaired pain sensation (HP:0007328)1.70930489
94Difficulty climbing stairs (HP:0003551)1.69742646
95Abnormality of oral frenula (HP:0000190)1.69030294
96Thoracolumbar scoliosis (HP:0002944)1.68340839
97Knee flexion contracture (HP:0006380)1.67840226
98Pulmonic stenosis (HP:0001642)1.64944421
99Popliteal pterygium (HP:0009756)1.62690479
100Curly hair (HP:0002212)1.62360094

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK16.58843186
2LATS14.16258843
3OBSCN3.95374566
4MARK33.06855916
5LATS23.02377675
6STK38L2.31615750
7MAP2K72.10286602
8ARAF2.01520828
9MAP3K101.90406377
10PDGFRA1.80572816
11NEK21.66983600
12PKN21.65482639
13MYLK1.65067905
14CSNK1A1L1.52267270
15CDK121.48557475
16SCYL21.48093093
17EEF2K1.46600520
18ICK1.45097203
19KSR21.44843164
20BCR1.44123255
21TTN1.42777580
22SGK2231.41933656
23SGK4941.41933656
24MAP3K11.39250726
25MOS1.38776590
26RET1.35264209
27RPS6KA41.32778299
28NEK91.28233353
29SGK21.26413628
30EPHA31.17187825
31STK381.16500884
32MAP3K91.16245720
33CCNB11.15019560
34SGK31.13677824
35TIE11.08941750
36CSNK1G31.05751080
37RPS6KB11.04965220
38MAP3K131.04317577
39BRD41.02494026
40NTRK11.00610506
41MAP3K50.99953144
42CDK60.97613042
43PRPF4B0.97517767
44EIF2AK30.92024718
45FGFR30.90546071
46CDK30.89832964
47RAF10.89283217
48CSNK1G10.88427195
49AKT30.86523200
50DYRK30.86174301
51CSNK1G20.85928104
52MAPK120.84207087
53CLK10.84162585
54KSR10.80343358
55PDGFRB0.79105634
56MTOR0.73112554
57MAP3K60.72785460
58CDK140.70701172
59PRKG20.65444210
60IRAK20.64438326
61MAP3K20.63076335
62RIPK10.61424503
63FGR0.61099751
64TRIB30.60974668
65FGFR40.60609936
66PAK20.60485628
67PDPK10.59036006
68NLK0.58607148
69EPHB10.56812083
70AKT20.51479958
71ERBB30.50902907
72RPS6KA50.50597522
73CAMK40.49734587
74PIK3CA0.46381486
75MAP3K70.45792359
76STK30.45543178
77MELK0.44393085
78JAK20.44171327
79MAPK100.43592139
80TRPM70.43354889
81EGFR0.43093931
82NEK60.42485474
83BTK0.41573218
84MAP3K40.41088480
85BMPR20.40060067
86PDK10.39881977
87PAK10.38352815
88DYRK1B0.37887585
89MET0.37461841
90JAK10.36311181
91MST1R0.34837020
92CDK50.34347322
93ROCK10.33204023
94BMX0.31938594
95CASK0.30792972
96BRAF0.30558425
97TGFBR20.29791603
98ROCK20.28216546
99PRKAA10.25390771
100DDR20.24622589

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.34585057
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.33003555
3Gap junction_Homo sapiens_hsa045401.89632796
4Endometrial cancer_Homo sapiens_hsa052131.81100304
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.67809120
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.64745899
7Dilated cardiomyopathy_Homo sapiens_hsa054141.57551717
8Focal adhesion_Homo sapiens_hsa045101.52523459
9Circadian rhythm_Homo sapiens_hsa047101.50247435
10ECM-receptor interaction_Homo sapiens_hsa045121.46598727
11Alcoholism_Homo sapiens_hsa050341.43228187
12Platelet activation_Homo sapiens_hsa046111.40100760
13Adherens junction_Homo sapiens_hsa045201.38854671
14Non-small cell lung cancer_Homo sapiens_hsa052231.34212787
15Thyroid cancer_Homo sapiens_hsa052161.32121342
16cGMP-PKG signaling pathway_Homo sapiens_hsa040221.30928244
17Glioma_Homo sapiens_hsa052141.30822503
18Insulin signaling pathway_Homo sapiens_hsa049101.24896825
19Long-term potentiation_Homo sapiens_hsa047201.22257355
20mTOR signaling pathway_Homo sapiens_hsa041501.21047071
21AMPK signaling pathway_Homo sapiens_hsa041521.19448049
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17074407
23Central carbon metabolism in cancer_Homo sapiens_hsa052301.14533220
24Oxytocin signaling pathway_Homo sapiens_hsa049211.12608775
25Neurotrophin signaling pathway_Homo sapiens_hsa047221.11547519
26Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09971949
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08568879
28ErbB signaling pathway_Homo sapiens_hsa040121.08386693
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07665304
30Chronic myeloid leukemia_Homo sapiens_hsa052201.07137259
31Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06695025
32Arginine biosynthesis_Homo sapiens_hsa002201.05980163
33Renin secretion_Homo sapiens_hsa049241.05128876
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04885152
35Systemic lupus erythematosus_Homo sapiens_hsa053221.03351375
36Renal cell carcinoma_Homo sapiens_hsa052111.00960887
37FoxO signaling pathway_Homo sapiens_hsa040681.00123449
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99690195
39Choline metabolism in cancer_Homo sapiens_hsa052310.99480346
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98542790
41Proteoglycans in cancer_Homo sapiens_hsa052050.97662329
42Complement and coagulation cascades_Homo sapiens_hsa046100.97001720
43Vascular smooth muscle contraction_Homo sapiens_hsa042700.95837024
44Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95120210
45Prostate cancer_Homo sapiens_hsa052150.92787441
46Glucagon signaling pathway_Homo sapiens_hsa049220.89896310
47TGF-beta signaling pathway_Homo sapiens_hsa043500.89644685
48Sphingolipid signaling pathway_Homo sapiens_hsa040710.88439362
49Pancreatic cancer_Homo sapiens_hsa052120.87873712
50Apoptosis_Homo sapiens_hsa042100.82918840
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82486380
52Estrogen signaling pathway_Homo sapiens_hsa049150.81911524
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81735189
54Fatty acid biosynthesis_Homo sapiens_hsa000610.79782930
55HIF-1 signaling pathway_Homo sapiens_hsa040660.77083964
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.77009841
57Colorectal cancer_Homo sapiens_hsa052100.76437476
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75974134
59Acute myeloid leukemia_Homo sapiens_hsa052210.75547742
60VEGF signaling pathway_Homo sapiens_hsa043700.75444779
61PPAR signaling pathway_Homo sapiens_hsa033200.73581991
62Small cell lung cancer_Homo sapiens_hsa052220.73359677
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73234622
64Melanoma_Homo sapiens_hsa052180.72362288
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72277618
66Gastric acid secretion_Homo sapiens_hsa049710.72106981
67Insulin resistance_Homo sapiens_hsa049310.71675001
68Phagosome_Homo sapiens_hsa041450.71255244
69Melanogenesis_Homo sapiens_hsa049160.69239597
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68816614
71Inositol phosphate metabolism_Homo sapiens_hsa005620.67441104
72PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67278760
73Hepatitis B_Homo sapiens_hsa051610.64445530
74Type II diabetes mellitus_Homo sapiens_hsa049300.63944003
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63349287
76GnRH signaling pathway_Homo sapiens_hsa049120.63039040
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61637207
78GABAergic synapse_Homo sapiens_hsa047270.61163890
79Amoebiasis_Homo sapiens_hsa051460.60955052
80Hedgehog signaling pathway_Homo sapiens_hsa043400.59473597
81Rap1 signaling pathway_Homo sapiens_hsa040150.59128046
82Circadian entrainment_Homo sapiens_hsa047130.58708752
83* Olfactory transduction_Homo sapiens_hsa047400.57796506
84Axon guidance_Homo sapiens_hsa043600.57235321
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.56515312
86Hippo signaling pathway_Homo sapiens_hsa043900.56152813
87MicroRNAs in cancer_Homo sapiens_hsa052060.55736918
88Calcium signaling pathway_Homo sapiens_hsa040200.54890921
89Long-term depression_Homo sapiens_hsa047300.54616891
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54376800
91Viral carcinogenesis_Homo sapiens_hsa052030.54186371
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54002673
93beta-Alanine metabolism_Homo sapiens_hsa004100.53110866
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53018256
95B cell receptor signaling pathway_Homo sapiens_hsa046620.52826064
96Endocytosis_Homo sapiens_hsa041440.52404026
97Pentose phosphate pathway_Homo sapiens_hsa000300.51749513
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51692309
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51541100
100Oocyte meiosis_Homo sapiens_hsa041140.51465689

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