OR2D3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of glucose import (GO:0046325)8.37854603
2synapsis (GO:0007129)7.31970260
3regulation of glucose import in response to insulin stimulus (GO:2001273)6.97382078
4negative regulation of glucose transport (GO:0010829)6.93644731
5regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.33223901
6interleukin-6-mediated signaling pathway (GO:0070102)5.26154200
7chromosome organization involved in meiosis (GO:0070192)5.21966392
8male meiosis I (GO:0007141)5.14537702
9male meiosis (GO:0007140)5.08678798
10DNA synthesis involved in DNA repair (GO:0000731)4.84230413
11piRNA metabolic process (GO:0034587)4.74903558
12protein maturation by protein folding (GO:0022417)4.67486893
13histone-serine phosphorylation (GO:0035404)4.36147779
14ER overload response (GO:0006983)4.30080841
15rRNA methylation (GO:0031167)4.28456641
16RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.27526654
17tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.27526654
18meiotic chromosome segregation (GO:0045132)4.23919688
19reciprocal DNA recombination (GO:0035825)4.14576991
20reciprocal meiotic recombination (GO:0007131)4.14576991
21synaptonemal complex assembly (GO:0007130)4.13860201
22nephron epithelium morphogenesis (GO:0072088)4.13352008
23nephron tubule morphogenesis (GO:0072078)4.13352008
24pseudouridine synthesis (GO:0001522)4.02763161
25synaptonemal complex organization (GO:0070193)3.93273800
26DNA methylation involved in gamete generation (GO:0043046)3.92364147
27meiosis I (GO:0007127)3.86879385
28intraciliary transport (GO:0042073)3.82402686
29GDP-mannose metabolic process (GO:0019673)3.81411236
30meiotic nuclear division (GO:0007126)3.80711658
31negative regulation of glycogen biosynthetic process (GO:0045719)3.73708663
32rRNA modification (GO:0000154)3.71059644
33acrosome assembly (GO:0001675)3.69157351
34regulation of DNA endoreduplication (GO:0032875)3.59113606
35RNA destabilization (GO:0050779)3.57911278
36meiotic cell cycle process (GO:1903046)3.46322104
37ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.42916916
38cellular response to ethanol (GO:0071361)3.35063555
39glyoxylate metabolic process (GO:0046487)3.35014903
40somatic hypermutation of immunoglobulin genes (GO:0016446)3.32391925
41somatic diversification of immune receptors via somatic mutation (GO:0002566)3.32391925
42snRNA transcription (GO:0009301)3.30776006
43positive regulation of histone H3-K4 methylation (GO:0051571)3.28139062
44cellular response to glucose starvation (GO:0042149)3.23659282
45cytochrome complex assembly (GO:0017004)3.23322864
46spermatid nucleus differentiation (GO:0007289)3.23241145
47RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.15043456
48glycosphingolipid biosynthetic process (GO:0006688)3.13207716
49DNA catabolic process, exonucleolytic (GO:0000738)3.12135710
50L-fucose catabolic process (GO:0042355)3.11276738
51fucose catabolic process (GO:0019317)3.11276738
52L-fucose metabolic process (GO:0042354)3.11276738
53positive regulation of mitochondrial fission (GO:0090141)3.08829409
54labyrinthine layer development (GO:0060711)3.08112489
55DNA double-strand break processing (GO:0000729)3.07448102
56mannosylation (GO:0097502)3.05678227
57nephron tubule formation (GO:0072079)3.05233333
58proteasome assembly (GO:0043248)3.03530333
59response to caffeine (GO:0031000)3.01698650
60negative regulation of DNA-dependent DNA replication (GO:2000104)3.00975808
61nucleotide-sugar biosynthetic process (GO:0009226)2.99422790
62behavioral response to nicotine (GO:0035095)2.94565221
63DNA replication checkpoint (GO:0000076)2.94201136
64regulation of type B pancreatic cell apoptotic process (GO:2000674)2.94094071
65regulation of nuclear cell cycle DNA replication (GO:0033262)2.92766818
66regulation of meiosis I (GO:0060631)2.91509443
67negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.88131310
68negative regulation of cellular response to insulin stimulus (GO:1900077)2.86860131
69rRNA catabolic process (GO:0016075)2.85408192
70regulation of energy homeostasis (GO:2000505)2.84471711
71histone exchange (GO:0043486)2.81370467
72intra-S DNA damage checkpoint (GO:0031573)2.77216898
73positive regulation of mitotic sister chromatid separation (GO:1901970)2.75567178
74positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.75567178
75positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.75567178
76negative regulation of glycogen metabolic process (GO:0070874)2.74093529
77indolalkylamine metabolic process (GO:0006586)2.73228008
78renal tubule morphogenesis (GO:0061333)2.72763841
79aldehyde catabolic process (GO:0046185)2.70374445
80signal peptide processing (GO:0006465)2.70158330
81spermatid development (GO:0007286)2.68462838
82peptidyl-histidine modification (GO:0018202)2.67364815
83protein complex biogenesis (GO:0070271)2.64883702
84dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.62433743
85negative regulation by host of viral transcription (GO:0043922)2.61509132
86telomere maintenance via recombination (GO:0000722)2.61098536
87dorsal/ventral axis specification (GO:0009950)2.59941976
88fatty acid homeostasis (GO:0055089)2.59730914
89DNA replication initiation (GO:0006270)2.59300585
90cell fate commitment involved in formation of primary germ layer (GO:0060795)2.56181589
91nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.54792580
92UDP-N-acetylglucosamine metabolic process (GO:0006047)2.54712127
93embryonic foregut morphogenesis (GO:0048617)2.54623567
94positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.52408546
95regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.52408546
96response to nitrosative stress (GO:0051409)2.51697357
97mitochondrial respiratory chain complex assembly (GO:0033108)2.50120494
98glycosylceramide metabolic process (GO:0006677)2.49716608
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.49273682
100response to pheromone (GO:0019236)13.1053390

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.46381792
2IGF1R_20145208_ChIP-Seq_DFB_Human3.54363165
3VDR_22108803_ChIP-Seq_LS180_Human3.18441140
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.14180349
5ZNF274_21170338_ChIP-Seq_K562_Hela2.90154114
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.86680868
7IRF1_19129219_ChIP-ChIP_H3396_Human2.76178441
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.66530536
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.58771834
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.52495690
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.48696321
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.37141434
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.25262921
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.21431905
15FUS_26573619_Chip-Seq_HEK293_Human2.19764434
16PADI4_21655091_ChIP-ChIP_MCF-7_Human2.12800893
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.04037477
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02506634
19ELK1_19687146_ChIP-ChIP_HELA_Human2.00115796
20VDR_23849224_ChIP-Seq_CD4+_Human1.99388691
21ER_23166858_ChIP-Seq_MCF-7_Human1.98604798
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89888530
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.89494159
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88873265
25P300_19829295_ChIP-Seq_ESCs_Human1.80559110
26MYC_18940864_ChIP-ChIP_HL60_Human1.80069075
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75935078
28FOXP3_21729870_ChIP-Seq_TREG_Human1.73862391
29YY1_21170310_ChIP-Seq_MESCs_Mouse1.68681437
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65496823
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.65090015
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64998096
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64910936
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.62944585
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55904913
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52232034
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50858191
38GATA3_21878914_ChIP-Seq_MCF-7_Human1.44172840
39AR_21572438_ChIP-Seq_LNCaP_Human1.44093254
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.41206519
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.40489027
42CBP_20019798_ChIP-Seq_JUKART_Human1.40467955
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40467955
44PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.39270377
45TAF15_26573619_Chip-Seq_HEK293_Human1.38979001
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38641045
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38315815
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34137313
49KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32067465
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30041622
51HOXB7_26014856_ChIP-Seq_BT474_Human1.27829947
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.25794954
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23999787
54EWS_26573619_Chip-Seq_HEK293_Human1.22408540
55TCF4_23295773_ChIP-Seq_U87_Human1.19889079
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.19505392
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19408858
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19408704
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18708552
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.18708552
61TP53_22573176_ChIP-Seq_HFKS_Human1.18630725
62FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16235145
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15789227
64AR_25329375_ChIP-Seq_VCAP_Human1.15307750
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13957844
66CEBPB_22108803_ChIP-Seq_LS180_Human1.13381333
67RUNX2_22187159_ChIP-Seq_PCA_Human1.11909580
68DCP1A_22483619_ChIP-Seq_HELA_Human1.10302260
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10036515
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07174275
71ERA_21632823_ChIP-Seq_H3396_Human1.07148413
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06931186
73TCF4_22108803_ChIP-Seq_LS180_Human1.05842648
74AR_20517297_ChIP-Seq_VCAP_Human1.02430491
75P53_21459846_ChIP-Seq_SAOS-2_Human1.02233454
76CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00118271
77SOX2_16153702_ChIP-ChIP_HESCs_Human0.99788483
78THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99663282
79CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99232140
80STAT3_23295773_ChIP-Seq_U87_Human0.99148874
81NANOG_19829295_ChIP-Seq_ESCs_Human0.97208018
82SOX2_19829295_ChIP-Seq_ESCs_Human0.97208018
83BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96472794
84YY1_22570637_ChIP-Seq_MALME-3M_Human0.95970919
85MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95615443
86PRDM14_20953172_ChIP-Seq_ESCs_Human0.95610400
87SALL4_22934838_ChIP-ChIP_CD34+_Human0.95386546
88FOXH1_21741376_ChIP-Seq_EPCs_Human0.93835546
89ETV1_20927104_ChIP-Seq_GIST48_Human0.93335591
90GATA3_26560356_Chip-Seq_TH2_Human0.91295446
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91098471
92SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90216470
93POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90133617
94SMAD4_21741376_ChIP-Seq_EPCs_Human0.90077668
95CDX2_22108803_ChIP-Seq_LS180_Human0.89841114
96CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89745480
97PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89436400
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89152922
99TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88682703
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.87734496

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system3.87107328
2MP0002653_abnormal_ependyma_morphology3.81046739
3MP0001529_abnormal_vocalization3.74294118
4MP0002132_abnormal_respiratory_system3.63669259
5MP0008877_abnormal_DNA_methylation3.17531081
6MP0002139_abnormal_hepatobiliary_system3.02628422
7MP0003718_maternal_effect2.93499163
8MP0003693_abnormal_embryo_hatching2.68269013
9MP0000015_abnormal_ear_pigmentation2.63382736
10MP0004145_abnormal_muscle_electrophysio2.55198163
11MP0008058_abnormal_DNA_repair2.46171123
12MP0003950_abnormal_plasma_membrane2.38534460
13MP0002102_abnormal_ear_morphology2.35590236
14MP0002254_reproductive_system_inflammat2.33988570
15MP0002210_abnormal_sex_determination2.28080137
16MP0001293_anophthalmia2.20250273
17MP0002234_abnormal_pharynx_morphology2.14803023
18MP0004036_abnormal_muscle_relaxation2.11530984
19MP0003283_abnormal_digestive_organ2.04537142
20MP0004270_analgesia1.96183777
21MP0001929_abnormal_gametogenesis1.88407975
22MP0003646_muscle_fatigue1.83912431
23MP0001188_hyperpigmentation1.80709362
24MP0010094_abnormal_chromosome_stability1.78832547
25MP0010386_abnormal_urinary_bladder1.76460900
26MP0003567_abnormal_fetal_cardiomyocyte1.75593505
27MP0001145_abnormal_male_reproductive1.69965861
28MP0003698_abnormal_male_reproductive1.63468053
29MP0002160_abnormal_reproductive_system1.60648539
30MP0004084_abnormal_cardiac_muscle1.57800218
31MP0005410_abnormal_fertilization1.54691958
32MP0004957_abnormal_blastocyst_morpholog1.49700452
33MP0001986_abnormal_taste_sensitivity1.49257737
34MP0008057_abnormal_DNA_replication1.49107168
35MP0000569_abnormal_digit_pigmentation1.48968729
36MP0000383_abnormal_hair_follicle1.44797768
37MP0002736_abnormal_nociception_after1.44492190
38MP0000653_abnormal_sex_gland1.43391026
39MP0002282_abnormal_trachea_morphology1.40903899
40MP0003941_abnormal_skin_development1.34806381
41MP0001299_abnormal_eye_distance/1.32012900
42MP0005084_abnormal_gallbladder_morpholo1.27710664
43MP0005389_reproductive_system_phenotype1.27026866
44MP0002127_abnormal_cardiovascular_syste1.20894851
45MP0002751_abnormal_autonomic_nervous1.20603900
46MP0005395_other_phenotype1.19788382
47MP0005551_abnormal_eye_electrophysiolog1.19127800
48MP0003656_abnormal_erythrocyte_physiolo1.15125602
49MP0002095_abnormal_skin_pigmentation1.14107714
50MP0001919_abnormal_reproductive_system1.11190866
51MP0008872_abnormal_physiological_respon1.10875922
52MP0003119_abnormal_digestive_system1.10314671
53MP0001119_abnormal_female_reproductive1.09099324
54MP0003786_premature_aging1.07676003
55MP0001968_abnormal_touch/_nociception1.07484749
56MP0008875_abnormal_xenobiotic_pharmacok1.04147998
57MP0008007_abnormal_cellular_replicative1.03630894
58MP0000631_abnormal_neuroendocrine_gland1.03388246
59MP0005645_abnormal_hypothalamus_physiol0.99862672
60MP0005386_behavior/neurological_phenoty0.99033233
61MP0004924_abnormal_behavior0.99033233
62MP0001764_abnormal_homeostasis0.96970530
63MP0000678_abnormal_parathyroid_gland0.96713841
64MP0002295_abnormal_pulmonary_circulatio0.96068539
65MP0005332_abnormal_amino_acid0.96021745
66MP0008775_abnormal_heart_ventricle0.95844133
67MP0010678_abnormal_skin_adnexa0.94821130
68MP0005670_abnormal_white_adipose0.92963784
69MP0006036_abnormal_mitochondrial_physio0.92374510
70MP0001984_abnormal_olfaction0.87222357
71MP0008995_early_reproductive_senescence0.86453689
72MP0001324_abnormal_eye_pigmentation0.85728701
73MP0004885_abnormal_endolymph0.85477097
74MP0001286_abnormal_eye_development0.85352455
75MP0002277_abnormal_respiratory_mucosa0.85295695
76MP0003937_abnormal_limbs/digits/tail_de0.84298229
77MP0005195_abnormal_posterior_eye0.84233676
78MP0000516_abnormal_urinary_system0.83859323
79MP0005367_renal/urinary_system_phenotyp0.83859323
80MP0006035_abnormal_mitochondrial_morpho0.81001570
81MP0003045_fibrosis0.80721315
82MP0004142_abnormal_muscle_tone0.80418394
83MP0002161_abnormal_fertility/fecundity0.80075439
84MP0003183_abnormal_peptide_metabolism0.79521745
85MP0001348_abnormal_lacrimal_gland0.77572439
86MP0005174_abnormal_tail_pigmentation0.77030537
87MP0009384_cardiac_valve_regurgitation0.72842038
88MP0003123_paternal_imprinting0.71678651
89MP0003880_abnormal_central_pattern0.71472845
90MP0003755_abnormal_palate_morphology0.70197175
91MP0002734_abnormal_mechanical_nocicepti0.68854308
92MP0002109_abnormal_limb_morphology0.68837802
93MP0001486_abnormal_startle_reflex0.67286281
94MP0001485_abnormal_pinna_reflex0.66824392
95MP0001270_distended_abdomen0.65546225
96MP0003943_abnormal_hepatobiliary_system0.64189928
97MP0003936_abnormal_reproductive_system0.62996483
98MP0003699_abnormal_female_reproductive0.62417417
99MP0005671_abnormal_response_to0.62251930
100MP0009703_decreased_birth_body0.55613901

Predicted human phenotypes

RankGene SetZ-score
1Nonimmune hydrops fetalis (HP:0001790)6.01192686
2Glucose intolerance (HP:0000833)4.87879277
3Type I transferrin isoform profile (HP:0003642)4.39984701
4Hypoplasia of the pons (HP:0012110)4.09967234
5Testicular atrophy (HP:0000029)3.97579676
6Abnormality of the pons (HP:0007361)3.93475765
7Reduced antithrombin III activity (HP:0001976)3.82360144
8Megaloblastic anemia (HP:0001889)3.78264978
9Spastic paraparesis (HP:0002313)3.76125306
10Cerebellar dysplasia (HP:0007033)3.52619257
11Abnormal glucose tolerance (HP:0001952)3.39806112
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.19804077
13Abnormal protein glycosylation (HP:0012346)3.18479419
14Abnormal glycosylation (HP:0012345)3.18479419
15Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.18479419
16Abnormal protein N-linked glycosylation (HP:0012347)3.18479419
17Hyperglycinuria (HP:0003108)3.07604067
18Thrombocytosis (HP:0001894)2.98984578
19Prolonged partial thromboplastin time (HP:0003645)2.95852356
20Pancreatic cysts (HP:0001737)2.94668183
21Spontaneous abortion (HP:0005268)2.91208012
22Hyperventilation (HP:0002883)2.89304705
23Abnormality of homocysteine metabolism (HP:0010919)2.85439650
24Homocystinuria (HP:0002156)2.85439650
25True hermaphroditism (HP:0010459)2.84822078
26Absent/shortened dynein arms (HP:0200106)2.71622668
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.71622668
28Hypoalbuminemia (HP:0003073)2.66652128
29Abnormal albumin level (HP:0012116)2.66652128
30Pancreatic fibrosis (HP:0100732)2.63975307
31Type II lissencephaly (HP:0007260)2.60979048
32Curly hair (HP:0002212)2.57081431
33Abnormality of methionine metabolism (HP:0010901)2.51802227
34Cutaneous melanoma (HP:0012056)2.46317997
35Hypoplasia of the uterus (HP:0000013)2.41327292
36Decreased circulating renin level (HP:0003351)2.40965158
37Abnormal number of erythroid precursors (HP:0012131)2.37229907
38Increased corneal curvature (HP:0100692)2.35774555
39Keratoconus (HP:0000563)2.35774555
40Gout (HP:0001997)2.32767840
41Cystic liver disease (HP:0006706)2.32331621
42Colon cancer (HP:0003003)2.29992016
43Global brain atrophy (HP:0002283)2.29494063
44Chronic sinusitis (HP:0011109)2.20354349
45Abnormality of glycine metabolism (HP:0010895)2.19788336
46Abnormality of serine family amino acid metabolism (HP:0010894)2.19788336
47Bilateral microphthalmos (HP:0007633)2.18457434
48Azoospermia (HP:0000027)2.16538756
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.15435971
50IgA deficiency (HP:0002720)2.14082390
51Abnormality of the vitamin B12 metabolism (HP:0004341)2.12929044
52Postaxial foot polydactyly (HP:0001830)2.11388553
53Anterior segment dysgenesis (HP:0007700)2.10911204
54Abnormality of cells of the erythroid lineage (HP:0012130)2.07627926
55Abnormal ciliary motility (HP:0012262)2.06563571
56Abnormality of the intrinsic pathway (HP:0010989)2.03542826
57Myelodysplasia (HP:0002863)2.02738427
58Hypokinesia (HP:0002375)2.01916815
59Chromsome breakage (HP:0040012)1.97981813
60Hyperglycinemia (HP:0002154)1.97959194
61Dysphonia (HP:0001618)1.97865996
62Sclerocornea (HP:0000647)1.95769210
63Microvesicular hepatic steatosis (HP:0001414)1.95074179
64Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.94827674
65Ependymoma (HP:0002888)1.94669573
66Abnormality of vitamin B metabolism (HP:0004340)1.93828961
67Stenosis of the external auditory canal (HP:0000402)1.93238783
68Hematochezia (HP:0002573)1.92802881
69Horseshoe kidney (HP:0000085)1.92090022
70Ectopic kidney (HP:0000086)1.92057875
71Central scotoma (HP:0000603)1.92031815
72Bifid tongue (HP:0010297)1.91051353
73Nuclear cataract (HP:0100018)1.90512922
74Abnormal pancreas size (HP:0012094)1.90283023
75Congenital stationary night blindness (HP:0007642)1.89004044
76Bicornuate uterus (HP:0000813)1.88264336
77Synostosis of carpal bones (HP:0005048)1.87851416
78Poor eye contact (HP:0000817)1.85496236
79Abnormality of midbrain morphology (HP:0002418)1.85299320
80Molar tooth sign on MRI (HP:0002419)1.85299320
81Anophthalmia (HP:0000528)1.84588732
82Multiple enchondromatosis (HP:0005701)1.81394499
83Small intestinal stenosis (HP:0012848)1.79696129
84Duodenal stenosis (HP:0100867)1.79696129
85Volvulus (HP:0002580)1.79679357
86Shawl scrotum (HP:0000049)1.79341908
87Aplasia/Hypoplasia of the spleen (HP:0010451)1.77775854
88Dandy-Walker malformation (HP:0001305)1.77041787
89Abnormality of the ileum (HP:0001549)1.76410655
90Tubulointerstitial nephritis (HP:0001970)1.73892844
91Chromosomal breakage induced by crosslinking agents (HP:0003221)1.73789074
92Abnormal spermatogenesis (HP:0008669)1.73445320
93Acute hepatic failure (HP:0006554)1.72932349
94Anencephaly (HP:0002323)1.71161826
95Albinism (HP:0001022)1.71006027
96Macrocytic anemia (HP:0001972)1.70849167
97Neutropenia (HP:0001875)1.70366749
98Abnormal lung lobation (HP:0002101)1.70346547
99Aplasia/hypoplasia of the uterus (HP:0008684)1.70254524
100Abnormal respiratory motile cilium physiology (HP:0012261)1.69997989

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRSK26.43671449
2CAMKK25.74399109
3PKN24.18454211
4FLT33.80568657
5MUSK3.31656622
6BRSK13.22488061
7AKT32.92379039
8TNIK2.87273275
9CAMKK12.72844852
10BMPR1B2.05853657
11IRAK41.98785796
12EEF2K1.92475046
13MKNK21.84935798
14IRAK11.83048429
15IRAK21.82666856
16EIF2AK31.77670072
17MAPKAPK51.71052727
18MET1.70751147
19STK38L1.49991547
20BUB11.41756787
21SRPK11.41596016
22MKNK11.40765079
23BCKDK1.39292508
24MAPKAPK31.38723667
25TLK11.35986210
26PASK1.34077744
27ACVR1B1.32706095
28PIK3CG1.26888651
29MAP3K91.23017799
30CDK191.22566840
31TEC1.20662104
32LATS11.05531325
33WNK41.01150832
34PLK20.98429913
35EPHA30.98001533
36GRK10.92026006
37RPS6KB20.89979133
38TESK20.87795702
39MAP4K20.85167697
40NUAK10.85019052
41OXSR10.81728484
42TIE10.81500823
43ITK0.77423203
44CDC70.76724701
45PAK30.69492213
46BRAF0.67086581
47PRKAA20.63472104
48ZAK0.62040910
49VRK20.61458134
50CHEK10.59378825
51PLK40.55722590
52MAPK110.55683661
53STK390.55665201
54WNK30.55222196
55TGFBR10.54903606
56STK110.52638105
57MAPK130.51254254
58VRK10.50514625
59TRPM70.50387385
60CSNK1G20.50212910
61BTK0.48365420
62PDK20.45263675
63IGF1R0.44285595
64ERBB30.44178853
65HCK0.43606511
66DYRK20.43444896
67PLK30.42875413
68IKBKE0.40339160
69CASK0.39554439
70PLK10.38076831
71TTK0.36900200
72ALK0.36247500
73DAPK20.36167729
74TAF10.34918741
75EPHA40.32707819
76ADRBK20.32149778
77TYK20.30745159
78NME10.29389192
79CAMK2B0.28740213
80ATR0.26569524
81TXK0.26020858
82CSNK1G10.25899012
83TRIM280.24784778
84JAK30.24689496
85CDK30.24336052
86WNK10.24214489
87STK40.23990845
88FGFR10.23953847
89STK30.23234970
90PRKAA10.22786714
91SIK20.22678088
92PRKACB0.21924632
93CSNK2A20.21433255
94EIF2AK10.21325760
95CSNK1A10.21152125
96ATM0.20936949
97CDK70.18691629
98PBK0.17908918
99INSRR0.17893450
100CSNK1A1L0.17208908

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.37072078
2Mismatch repair_Homo sapiens_hsa034303.02968124
3DNA replication_Homo sapiens_hsa030302.86119232
4Caffeine metabolism_Homo sapiens_hsa002322.72262451
5Propanoate metabolism_Homo sapiens_hsa006402.69914372
6Basal transcription factors_Homo sapiens_hsa030222.67739423
7RNA polymerase_Homo sapiens_hsa030202.65645007
8RNA degradation_Homo sapiens_hsa030182.60608442
9Homologous recombination_Homo sapiens_hsa034402.47012588
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.23104422
11Proteasome_Homo sapiens_hsa030502.17789495
12Fanconi anemia pathway_Homo sapiens_hsa034601.96210941
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.89977665
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.89001835
15Regulation of autophagy_Homo sapiens_hsa041401.88368843
16One carbon pool by folate_Homo sapiens_hsa006701.74087770
17Nucleotide excision repair_Homo sapiens_hsa034201.73988290
18Non-homologous end-joining_Homo sapiens_hsa034501.65573871
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.64257637
20Ribosome_Homo sapiens_hsa030101.64095853
21Tryptophan metabolism_Homo sapiens_hsa003801.62860398
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61326505
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.60214351
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.48078327
25RNA transport_Homo sapiens_hsa030131.47496320
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40974219
27Ether lipid metabolism_Homo sapiens_hsa005651.39782356
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36745746
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32578723
30Fatty acid degradation_Homo sapiens_hsa000711.29104285
31Pyrimidine metabolism_Homo sapiens_hsa002401.28763159
32Linoleic acid metabolism_Homo sapiens_hsa005911.28335943
33beta-Alanine metabolism_Homo sapiens_hsa004101.24559476
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23064656
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20741359
36Parkinsons disease_Homo sapiens_hsa050121.18756096
37Spliceosome_Homo sapiens_hsa030401.13961369
38Base excision repair_Homo sapiens_hsa034101.11390333
39Primary immunodeficiency_Homo sapiens_hsa053401.11268613
40Vitamin digestion and absorption_Homo sapiens_hsa049771.07987973
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.03703880
42Purine metabolism_Homo sapiens_hsa002300.97078787
43Arginine and proline metabolism_Homo sapiens_hsa003300.96343622
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95932512
45Huntingtons disease_Homo sapiens_hsa050160.94565184
46Hedgehog signaling pathway_Homo sapiens_hsa043400.92713339
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91025678
48N-Glycan biosynthesis_Homo sapiens_hsa005100.90741084
49Selenocompound metabolism_Homo sapiens_hsa004500.90659359
50Glycerolipid metabolism_Homo sapiens_hsa005610.87748729
51Phototransduction_Homo sapiens_hsa047440.85467902
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.83633527
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.81336973
54mRNA surveillance pathway_Homo sapiens_hsa030150.79317622
55Pyruvate metabolism_Homo sapiens_hsa006200.78480319
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.78002464
57Fat digestion and absorption_Homo sapiens_hsa049750.74732540
58Retinol metabolism_Homo sapiens_hsa008300.73638094
59Cell cycle_Homo sapiens_hsa041100.73427303
60Butanoate metabolism_Homo sapiens_hsa006500.73393218
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72549539
62Sulfur metabolism_Homo sapiens_hsa009200.70919641
63Oxidative phosphorylation_Homo sapiens_hsa001900.69394754
64Metabolic pathways_Homo sapiens_hsa011000.68002242
65Taste transduction_Homo sapiens_hsa047420.66311873
66Histidine metabolism_Homo sapiens_hsa003400.64983646
67Chemical carcinogenesis_Homo sapiens_hsa052040.61409653
68Peroxisome_Homo sapiens_hsa041460.61246422
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.61148284
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59946900
71Fructose and mannose metabolism_Homo sapiens_hsa000510.59502474
72Sulfur relay system_Homo sapiens_hsa041220.58140139
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57084331
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54884843
75Glutathione metabolism_Homo sapiens_hsa004800.52714034
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52286890
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51377525
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47252477
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45918298
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44797108
81Starch and sucrose metabolism_Homo sapiens_hsa005000.44236664
82Alzheimers disease_Homo sapiens_hsa050100.43585610
83Steroid biosynthesis_Homo sapiens_hsa001000.43380366
84Basal cell carcinoma_Homo sapiens_hsa052170.42068010
85Sphingolipid metabolism_Homo sapiens_hsa006000.40999287
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38694718
87* Olfactory transduction_Homo sapiens_hsa047400.37530467
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36932282
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34499392
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34306296
91Tyrosine metabolism_Homo sapiens_hsa003500.33060926
92Arachidonic acid metabolism_Homo sapiens_hsa005900.33006795
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31100021
94TGF-beta signaling pathway_Homo sapiens_hsa043500.29574812
95Oocyte meiosis_Homo sapiens_hsa041140.28770288
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.26769198
97Dorso-ventral axis formation_Homo sapiens_hsa043200.26701416
98Salivary secretion_Homo sapiens_hsa049700.25971992
99Systemic lupus erythematosus_Homo sapiens_hsa053220.25956263
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24750373

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