OR2H1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)9.60863497
2chromosome condensation (GO:0030261)9.48710532
3sperm capacitation (GO:0048240)9.29363499
4DNA packaging (GO:0006323)9.09030259
5plasma membrane fusion (GO:0045026)8.77669695
6single strand break repair (GO:0000012)8.36149789
7microtubule depolymerization (GO:0007019)8.33339720
8spermatid nucleus differentiation (GO:0007289)7.97421158
9spermatid development (GO:0007286)7.93038744
10sperm-egg recognition (GO:0035036)7.48952104
11multicellular organism reproduction (GO:0032504)6.98045490
12microtubule polymerization or depolymerization (GO:0031109)6.89328764
13binding of sperm to zona pellucida (GO:0007339)6.88526744
14sexual reproduction (GO:0019953)6.74115058
15calcium ion-dependent exocytosis (GO:0017156)6.70861150
16reproduction (GO:0000003)6.67315651
17rRNA methylation (GO:0031167)6.63805666
18protein polyglutamylation (GO:0018095)6.58347081
19negative regulation of inclusion body assembly (GO:0090084)6.53500563
20protein targeting to Golgi (GO:0000042)6.45702436
21phosphatidylethanolamine biosynthetic process (GO:0006646)6.28386959
22establishment of protein localization to Golgi (GO:0072600)6.28194505
23cell-cell recognition (GO:0009988)6.16284642
24axonemal dynein complex assembly (GO:0070286)6.10205510
25spermatogenesis (GO:0007283)6.07831522
26male gamete generation (GO:0048232)6.05685302
27retrograde transport, vesicle recycling within Golgi (GO:0000301)5.99605166
28phosphatidylethanolamine metabolic process (GO:0046337)5.79012832
29centriole replication (GO:0007099)5.63601222
30microtubule severing (GO:0051013)5.60064481
31rRNA modification (GO:0000154)5.57446130
32gamete generation (GO:0007276)5.53091361
33cellular ketone body metabolic process (GO:0046950)5.51939408
34positive regulation of Rab GTPase activity (GO:0032851)5.33689770
35regulation of Rab GTPase activity (GO:0032313)5.33689770
36antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.29620336
37regulation of cilium movement (GO:0003352)4.96401830
38centriole assembly (GO:0098534)4.92770254
39ketone body metabolic process (GO:1902224)4.86914000
40motile cilium assembly (GO:0044458)4.86773634
41regulation of transcription involved in cell fate commitment (GO:0060850)4.82752694
42single fertilization (GO:0007338)4.82446358
43cilium or flagellum-dependent cell motility (GO:0001539)4.75318041
44chromatin silencing (GO:0006342)4.65269943
45regulation of inclusion body assembly (GO:0090083)4.63146602
46protein localization to Golgi apparatus (GO:0034067)4.59788176
47cell wall macromolecule catabolic process (GO:0016998)4.53952074
48RNA destabilization (GO:0050779)4.49602638
49germ cell development (GO:0007281)4.44728005
50multicellular organismal reproductive process (GO:0048609)4.43420179
51cell wall macromolecule metabolic process (GO:0044036)4.41455296
52regulation of centriole replication (GO:0046599)4.33046315
53cellular process involved in reproduction in multicellular organism (GO:0022412)4.28575405
54seminiferous tubule development (GO:0072520)4.06405014
55coenzyme catabolic process (GO:0009109)4.03009420
56nucleus organization (GO:0006997)4.01661596
57fertilization (GO:0009566)4.00575802
58musculoskeletal movement (GO:0050881)3.81796714
59multicellular organismal movement (GO:0050879)3.81796714
60negative regulation of Rho protein signal transduction (GO:0035024)3.81498906
61epithelial cilium movement (GO:0003351)3.81089208
62glycerol ether metabolic process (GO:0006662)3.75430790
63organic cation transport (GO:0015695)3.58804613
64ether metabolic process (GO:0018904)3.47339376
65cilium movement (GO:0003341)3.43222609
66cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.41155771
67regulation of microtubule-based movement (GO:0060632)3.40299006
68cerebral cortex neuron differentiation (GO:0021895)3.37174727
69response to acidic pH (GO:0010447)3.35220951
70peptidyl-threonine dephosphorylation (GO:0035970)3.32001509
71polyamine biosynthetic process (GO:0006596)3.24107358
72cellular response to pH (GO:0071467)3.23755601
73regulation of interleukin-13 production (GO:0032656)3.21032582
74cranial nerve morphogenesis (GO:0021602)3.17405394
75negative regulation of gene expression, epigenetic (GO:0045814)3.14682532
76glomerular visceral epithelial cell development (GO:0072015)3.14576818
77mesenchymal cell differentiation involved in kidney development (GO:0072161)3.12049755
78mesenchymal cell differentiation involved in renal system development (GO:2001012)3.12049755
79membrane protein intracellular domain proteolysis (GO:0031293)3.10857219
80protein-DNA complex disassembly (GO:0032986)3.10072007
81nucleosome disassembly (GO:0006337)3.10072007
82protein depolymerization (GO:0051261)3.09749234
83histone H3-K9 demethylation (GO:0033169)3.09201836
84regulation of T-helper 2 cell differentiation (GO:0045628)3.08705014
85glomerular epithelial cell development (GO:0072310)3.05464222
86homeostasis of number of cells within a tissue (GO:0048873)3.03622725
87NAD biosynthetic process (GO:0009435)3.02180574
88cell differentiation involved in metanephros development (GO:0072202)3.01872786
89multicellular organismal development (GO:0007275)2.97277203
90cell recognition (GO:0008037)2.96495458
91regulation of somitogenesis (GO:0014807)2.95975965
92negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.95358824
93microtubule nucleation (GO:0007020)2.93710591
94DNA conformation change (GO:0071103)2.88822025
95pattern specification involved in kidney development (GO:0061004)2.78396783
96Golgi to endosome transport (GO:0006895)2.74587018
97metanephric mesenchyme development (GO:0072075)2.72480043
98acrosome reaction (GO:0007340)12.2450496
99fusion of sperm to egg plasma membrane (GO:0007342)11.5816424
100sperm motility (GO:0030317)11.5695443

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.86454530
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.74868283
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.73654779
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.41338887
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.41338887
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21961424
7IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.17203024
8CBP_20019798_ChIP-Seq_JUKART_Human2.17203024
9ELF1_20517297_ChIP-Seq_JURKAT_Human2.10193224
10EZH2_22144423_ChIP-Seq_EOC_Human2.03873937
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03515668
12VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.03416667
13ERA_21632823_ChIP-Seq_H3396_Human1.96321178
14DROSHA_22980978_ChIP-Seq_HELA_Human1.95967043
15RAC3_21632823_ChIP-Seq_H3396_Human1.85065943
16NANOG_20526341_ChIP-Seq_ESCs_Human1.82219619
17RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.81759127
18EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.81229163
19EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.81144498
20FUS_26573619_Chip-Seq_HEK293_Human1.80572614
21WDR5_24793694_ChIP-Seq_LNCAP_Human1.79917516
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74575551
23BCL6_27268052_Chip-Seq_Bcells_Human1.67294670
24UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66611227
25* CTCF_27219007_Chip-Seq_Bcells_Human1.64463866
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64230200
27E2F1_20622854_ChIP-Seq_HELA_Human1.62640059
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62601610
29TAF2_19829295_ChIP-Seq_ESCs_Human1.59963986
30TDRD3_21172665_ChIP-Seq_MCF-7_Human1.57800053
31YY1_22570637_ChIP-Seq_MALME-3M_Human1.57046417
32SMC4_20622854_ChIP-Seq_HELA_Human1.57010443
33ER_23166858_ChIP-Seq_MCF-7_Human1.56835892
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55540999
35BCOR_27268052_Chip-Seq_Bcells_Human1.52276025
36SMAD4_21741376_ChIP-Seq_EPCs_Human1.50798091
37PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.50583240
38CTCF_20526341_ChIP-Seq_ESCs_Human1.50477671
39* MYC_19829295_ChIP-Seq_ESCs_Human1.49183335
40P68_20966046_ChIP-Seq_HELA_Human1.49170409
41ARNT_22903824_ChIP-Seq_MCF-7_Human1.47767773
42PHF8_20622854_ChIP-Seq_HELA_Human1.47526519
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44612091
44ETV2_25802403_ChIP-Seq_MESCs_Mouse1.43664340
45OCT4_20526341_ChIP-Seq_ESCs_Human1.43651294
46TP63_22573176_ChIP-Seq_HFKS_Human1.42243104
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39029948
48AR_25329375_ChIP-Seq_VCAP_Human1.36643973
49LXR_22292898_ChIP-Seq_THP-1_Human1.36378959
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36163408
51TP53_18474530_ChIP-ChIP_U2OS_Human1.35361218
52SMAD3_21741376_ChIP-Seq_ESCs_Human1.34484241
53P300_27268052_Chip-Seq_Bcells_Human1.34329045
54HNFA_21074721_ChIP-Seq_CACO-2_Human1.33529099
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.31810511
56SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.31154529
57RBPJ_21746931_ChIP-Seq_IB4_Human1.30394965
58CBX2_22325352_ChIP-Seq_293T-Rex_Human1.30320927
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30259630
60ERG_20517297_ChIP-Seq_VCAP_Human1.29680116
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29240600
62* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.29161988
63CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.27680524
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.26745985
65ETV1_20927104_ChIP-Seq_GIST48_Human1.24517852
66TAF15_26573619_Chip-Seq_HEK293_Human1.24413836
67CEBPB_22108803_ChIP-Seq_LS180_Human1.23691475
68P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.23543373
69P300_19829295_ChIP-Seq_ESCs_Human1.23331039
70SOX2_22085726_ChIP-Seq_NPCs_Mouse1.21898514
71P53_21459846_ChIP-Seq_SAOS-2_Human1.21421592
72KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.18940468
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.17794721
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16371520
75NFYB_21822215_ChIP-Seq_K562_Human1.15034098
76EZH2_27294783_Chip-Seq_ESCs_Mouse1.14376074
77ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14261239
78ZNF274_21170338_ChIP-Seq_K562_Hela1.13894970
79NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13596495
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13316429
81TBL1_22424771_ChIP-Seq_293T_Human1.13265823
82SMRT_27268052_Chip-Seq_Bcells_Human1.12960918
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12800515
84SMAD4_21741376_ChIP-Seq_HESCs_Human1.12400644
85RUNX_20019798_ChIP-Seq_JUKART_Human1.12043264
86RUNX1_26923725_Chip-Seq_HPCs_Mouse1.11442167
87SA1_27219007_Chip-Seq_Bcells_Human1.09875663
88PHF8_20622853_ChIP-Seq_HELA_Human1.08708504
89AR_21572438_ChIP-Seq_LNCaP_Human1.06619515
90RUNX2_22187159_ChIP-Seq_PCA_Human1.06231585
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04998310
92GATA6_21074721_ChIP-Seq_CACO-2_Human1.04469587
93OCT1_27270436_Chip-Seq_PROSTATE_Human0.98441865
94NFYA_21822215_ChIP-Seq_K562_Human0.98381822
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98092238
96HOXB7_26014856_ChIP-Seq_BT474_Human0.97328203
97SPI1_20517297_ChIP-Seq_HL60_Human0.95931987
98PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.95844464
99CBX2_27304074_Chip-Seq_ESCs_Mouse0.95004125
100KLF5_25053715_ChIP-Seq_YYC3_Human0.94879537

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.11833235
2MP0003878_abnormal_ear_physiology5.11833235
3MP0005670_abnormal_white_adipose4.55263903
4MP0003698_abnormal_male_reproductive4.39194265
5MP0001929_abnormal_gametogenesis3.75834477
6MP0001348_abnormal_lacrimal_gland3.64809762
7MP0000678_abnormal_parathyroid_gland2.61975033
8MP0002161_abnormal_fertility/fecundity2.44379389
9MP0003718_maternal_effect2.16904075
10MP0003011_delayed_dark_adaptation2.11889188
11MP0002132_abnormal_respiratory_system2.11847045
12MP0005410_abnormal_fertilization12.2548490
13MP0003646_muscle_fatigue1.90405303
14MP0002234_abnormal_pharynx_morphology1.80615055
15MP0002249_abnormal_larynx_morphology1.77963798
16MP0005379_endocrine/exocrine_gland_phen1.72962766
17MP0005423_abnormal_somatic_nervous1.65824080
18MP0002210_abnormal_sex_determination1.60869222
19MP0001485_abnormal_pinna_reflex1.59026632
20MP0002282_abnormal_trachea_morphology1.47805540
21MP0004510_myositis1.44610133
22MP0001486_abnormal_startle_reflex1.44357921
23MP0005310_abnormal_salivary_gland1.41902534
24MP0009053_abnormal_anal_canal1.39192295
25MP0002735_abnormal_chemical_nociception1.37385105
26MP0002822_catalepsy1.34469093
27MP0001145_abnormal_male_reproductive1.33449261
28MP0004742_abnormal_vestibular_system1.31368809
29MP0000653_abnormal_sex_gland1.27606544
30MP0000534_abnormal_ureter_morphology1.26315699
31MP0005451_abnormal_body_composition1.25488397
32MP0001765_abnormal_ion_homeostasis1.22380149
33MP0002127_abnormal_cardiovascular_syste1.20062154
34MP0004859_abnormal_synaptic_plasticity1.18191880
35MP0002138_abnormal_hepatobiliary_system1.17043742
36MP0001968_abnormal_touch/_nociception1.16599531
37MP0001963_abnormal_hearing_physiology1.13671868
38MP0000026_abnormal_inner_ear1.09178132
39MP0003879_abnormal_hair_cell1.04339156
40MP0005248_abnormal_Harderian_gland1.00334735
41MP0005395_other_phenotype0.97699639
42MP0000049_abnormal_middle_ear0.90699312
43MP0002733_abnormal_thermal_nociception0.90367697
44MP0002229_neurodegeneration0.90253004
45MP0000955_abnormal_spinal_cord0.88705223
46MP0008569_lethality_at_weaning0.86850026
47MP0000681_abnormal_thyroid_gland0.85523777
48MP0000566_synostosis0.83386537
49MP0005551_abnormal_eye_electrophysiolog0.82493880
50MP0009115_abnormal_fat_cell0.81899210
51MP0002067_abnormal_sensory_capabilities0.79036208
52MP0005367_renal/urinary_system_phenotyp0.78482209
53MP0000516_abnormal_urinary_system0.78482209
54MP0005083_abnormal_biliary_tract0.74974027
55MP0005666_abnormal_adipose_tissue0.73070667
56MP0001905_abnormal_dopamine_level0.72360620
57MP0004085_abnormal_heartbeat0.71031600
58MP0005167_abnormal_blood-brain_barrier0.70369622
59MP0005253_abnormal_eye_physiology0.68876579
60MP0002557_abnormal_social/conspecific_i0.68126366
61MP0001666_abnormal_nutrient_absorption0.66823006
62MP0002572_abnormal_emotion/affect_behav0.66676892
63MP0005636_abnormal_mineral_homeostasis0.66293354
64MP0004484_altered_response_of0.63235668
65MP0005375_adipose_tissue_phenotype0.62402829
66MP0008877_abnormal_DNA_methylation0.60878444
67MP0001970_abnormal_pain_threshold0.59780922
68MP0001879_abnormal_lymphatic_vessel0.57159164
69MP0002734_abnormal_mechanical_nocicepti0.57119806
70MP0008961_abnormal_basal_metabolism0.56832576
71MP0002272_abnormal_nervous_system0.53330700
72MP0000003_abnormal_adipose_tissue0.52263350
73MP0001440_abnormal_grooming_behavior0.51312007
74MP0001501_abnormal_sleep_pattern0.50340502
75MP0009745_abnormal_behavioral_response0.49277667
76MP0009697_abnormal_copulation0.49103466
77MP0003283_abnormal_digestive_organ0.47898844
78MP0008995_early_reproductive_senescence0.46032817
79MP0003119_abnormal_digestive_system0.45792752
80MP0002653_abnormal_ependyma_morphology0.45683042
81MP0003137_abnormal_impulse_conducting0.44547975
82MP0005535_abnormal_body_temperature0.44334820
83MP0000249_abnormal_blood_vessel0.43410999
84MP0005623_abnormal_meninges_morphology0.42069437
85MP0000470_abnormal_stomach_morphology0.40276400
86MP0003880_abnormal_central_pattern0.40267651
87MP0003699_abnormal_female_reproductive0.39972738
88MP0003635_abnormal_synaptic_transmissio0.39244681
89MP0003936_abnormal_reproductive_system0.39241139
90MP0001984_abnormal_olfaction0.38730922
91MP0000230_abnormal_systemic_arterial0.38216877
92MP0003077_abnormal_cell_cycle0.37479953
93MP0002928_abnormal_bile_duct0.37141452
94MP0003631_nervous_system_phenotype0.36104986
95MP0006292_abnormal_olfactory_placode0.34842041
96MP0005084_abnormal_gallbladder_morpholo0.34782883
97MP0009046_muscle_twitch0.34777097
98MP0004036_abnormal_muscle_relaxation0.34600915
99MP0000613_abnormal_salivary_gland0.34584121
100MP0002882_abnormal_neuron_morphology0.32826664

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.81324922
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.05663532
3Absent/shortened dynein arms (HP:0200106)6.05663532
4Asymmetric septal hypertrophy (HP:0001670)5.40648911
5Bony spicule pigmentary retinopathy (HP:0007737)5.22966832
6Attenuation of retinal blood vessels (HP:0007843)5.22309093
7Abnormal ciliary motility (HP:0012262)4.77624586
8Bell-shaped thorax (HP:0001591)4.59745633
9Abnormal respiratory motile cilium physiology (HP:0012261)4.56726678
10Abnormal respiratory epithelium morphology (HP:0012253)4.45575310
11Abnormal respiratory motile cilium morphology (HP:0005938)4.45575310
12Tubulointerstitial nephritis (HP:0001970)4.40169130
13Male infertility (HP:0003251)4.34287119
14Chronic hepatic failure (HP:0100626)4.33004643
15Resting tremor (HP:0002322)4.30927264
16Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.25252375
17Hypoplastic ischia (HP:0003175)4.25056411
18Abnormal rod and cone electroretinograms (HP:0008323)4.24067207
19Hyperkalemia (HP:0002153)4.18560510
20Abnormality of macular pigmentation (HP:0008002)4.13784559
21Infertility (HP:0000789)4.06085444
22Nasal polyposis (HP:0100582)3.94172579
23Potter facies (HP:0002009)3.93212778
24Facial shape deformation (HP:0011334)3.93212778
25Enlarged epiphyses (HP:0010580)3.91683029
26Abnormality of the ischium (HP:0003174)3.77687903
27Aplasia/Hypoplasia of the earlobes (HP:0009906)3.67453158
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.65423157
29Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.55729761
30Cone-rod dystrophy (HP:0000548)3.55171957
31Azoospermia (HP:0000027)3.42570808
32Abnormal spermatogenesis (HP:0008669)3.39354946
33Impulsivity (HP:0100710)3.28059110
34Abnormality of the nasal mucosa (HP:0000433)3.17162524
35Hypoplasia of the thymus (HP:0000778)3.09772631
36Unilateral renal agenesis (HP:0000122)3.03296627
37Postural instability (HP:0002172)2.93997741
38Rhinitis (HP:0012384)2.89456441
39Abnormal urine output (HP:0012590)2.81480838
40Congenital malformation of the right heart (HP:0011723)2.77594936
41Double outlet right ventricle (HP:0001719)2.77594936
42Nephronophthisis (HP:0000090)2.76806554
43Abnormality of the aortic arch (HP:0012303)2.70130247
44Epiphyseal dysplasia (HP:0002656)2.68047747
45Progressive sensorineural hearing impairment (HP:0000408)2.67028397
46Abnormality of the costochondral junction (HP:0000919)2.66482817
47Generalized aminoaciduria (HP:0002909)2.62940696
48Hypoalphalipoproteinemia (HP:0003233)2.60118543
49Stage 5 chronic kidney disease (HP:0003774)2.58841356
50Progressive cerebellar ataxia (HP:0002073)2.56108390
51Truncal obesity (HP:0001956)2.50401332
52Renal dysplasia (HP:0000110)2.49419642
53Abnormality of potassium homeostasis (HP:0011042)2.45698424
54Absent epiphyses (HP:0010577)2.45498811
55Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.45498811
56Abnormality of renal excretion (HP:0011036)2.40816352
57Amelogenesis imperfecta (HP:0000705)2.40663677
58Polydipsia (HP:0001959)2.40601335
59Abnormal drinking behavior (HP:0030082)2.40601335
60Portal hypertension (HP:0001409)2.36677030
61Abnormality of the renal medulla (HP:0100957)2.30736614
62Abnormality of dental color (HP:0011073)2.29295920
63Flattened epiphyses (HP:0003071)2.29041544
64Polyuria (HP:0000103)2.24162957
65Abnormality of the parathyroid morphology (HP:0011766)2.23337817
66Ventricular tachycardia (HP:0004756)2.21403653
67Abnormality of the pubic bones (HP:0003172)2.20688145
68Abnormality of the hepatic vasculature (HP:0006707)2.16904192
69Abnormality of the epiphysis of the femoral head (HP:0010574)2.14076177
70Tetany (HP:0001281)2.10759521
71Tubulointerstitial abnormality (HP:0001969)2.09277860
72Insulin-resistant diabetes mellitus (HP:0000831)2.09052569
73Bronchiectasis (HP:0002110)2.08275750
74Decreased central vision (HP:0007663)2.08201590
75Renovascular hypertension (HP:0100817)2.04296983
76Recurrent corneal erosions (HP:0000495)2.04104533
77Abnormality of femoral epiphyses (HP:0006499)1.99922904
78Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.99922904
79Menstrual irregularities (HP:0000858)1.99724813
80Spastic paraparesis (HP:0002313)1.99519692
81Hyponatremia (HP:0002902)1.99322141
82Mixed hearing impairment (HP:0000410)1.98814821
83Aplasia/Hypoplasia of the sacrum (HP:0008517)1.94613186
84Hypophosphatemic rickets (HP:0004912)1.94343231
85Widely patent fontanelles and sutures (HP:0004492)1.93712167
86Osteomalacia (HP:0002749)1.91305694
87Abnormality of the femoral head (HP:0003368)1.90591267
88Recurrent pneumonia (HP:0006532)1.89726636
89Failure to thrive in infancy (HP:0001531)1.85282682
90Focal segmental glomerulosclerosis (HP:0000097)1.82856614
91Short ribs (HP:0000773)1.81887184
92Chronic bronchitis (HP:0004469)1.79982253
93Increased purine levels (HP:0004368)1.77258664
94Hyperuricemia (HP:0002149)1.77258664
95Intellectual disability, moderate (HP:0002342)1.75923875
96Flat capital femoral epiphysis (HP:0003370)1.74266922
97Hyperthyroidism (HP:0000836)1.74146659
98Renal Fanconi syndrome (HP:0001994)1.73758974
99Abnormal ventriculo-arterial connection (HP:0011563)1.72990669
100Abnormal connection of the cardiac segments (HP:0011545)1.72990669

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.41302882
2TESK16.14807896
3DDR25.47141385
4INSRR4.27151190
5MAP4K23.45884236
6PLK23.14361238
7STK383.06285845
8BRD43.00277159
9PNCK2.87310698
10MAPK152.45431183
11PRKD32.17695264
12STK38L2.11414203
13CAMK1G2.10423071
14PIK3CG1.72223458
15MST1R1.72200942
16WNK11.69916447
17PDPK11.51764082
18PDK11.43521340
19CDK71.34308966
20DYRK1B1.34272420
21CDK121.17388240
22PTK2B1.15168359
23NEK61.05037400
24KSR20.98097177
25MAP3K90.96145031
26AKT30.74951019
27UHMK10.74443570
28PRKG20.73120342
29CAMK1D0.72982639
30MAP3K20.71923608
31RPS6KA20.71909568
32LATS20.70135553
33MAP3K110.67704716
34LATS10.67159741
35PRKG10.67152655
36MAP2K20.67038431
37STK390.64339017
38PRKAA20.61646717
39RPS6KA10.61381825
40TYRO30.57964135
41SIK20.57790106
42WNK40.57589909
43BRAF0.54976046
44CAMK10.52406061
45ROCK10.52234593
46MAP3K80.51875105
47MUSK0.48657373
48NTRK30.47599765
49CDK30.46831073
50GSK3B0.43340137
51RPS6KC10.43091403
52RPS6KL10.43091403
53CDK20.41995136
54CDK40.41578983
55RPS6KA60.40987929
56MAPK10.39433864
57ADRBK20.38693057
58PRKCG0.38117239
59CDK10.37302864
60FRK0.37242649
61TESK20.37073391
62CAMK40.36304511
63SGK2230.35455952
64SGK4940.35455952
65MTOR0.32266691
66MAPK80.31286801
67MAP3K10.30454684
68MARK10.30230052
69MAP3K40.30167510
70PRKCZ0.29313749
71CHEK10.27924458
72TIE10.27904792
73BMPR1B0.26277000
74SGK10.25299181
75OXSR10.24913744
76PRKCB0.24300530
77MAPK100.23627459
78DYRK30.23053217
79PKN10.21802872
80MAPK140.21340703
81MARK20.20434100
82ARAF0.19683505
83MAPK110.17806763
84RIPK40.17555329
85AKT10.16810537
86MET0.14857189
87FER0.14273733
88BLK0.13561452
89JAK30.13270954
90PRKCE0.12685300
91CHUK0.12516073
92PRKACA0.12314986
93PRKACB0.11266287
94IKBKB0.11231847
95BRSK10.09958777
96FGFR30.09824212
97PINK10.09016946
98TNIK0.08807521
99CAMK2A0.08170319
100KIT0.06929025

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.87223106
2Fatty acid biosynthesis_Homo sapiens_hsa000615.80707374
3Butanoate metabolism_Homo sapiens_hsa006502.72687723
4* Olfactory transduction_Homo sapiens_hsa047402.64648821
5Glycerophospholipid metabolism_Homo sapiens_hsa005642.12790397
6Allograft rejection_Homo sapiens_hsa053302.09717043
7Autoimmune thyroid disease_Homo sapiens_hsa053202.03671080
8Type I diabetes mellitus_Homo sapiens_hsa049402.01198982
9Taste transduction_Homo sapiens_hsa047421.91197472
10Graft-versus-host disease_Homo sapiens_hsa053321.90259648
11Antigen processing and presentation_Homo sapiens_hsa046121.73252906
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.70576974
13Dorso-ventral axis formation_Homo sapiens_hsa043201.66724873
14Fatty acid degradation_Homo sapiens_hsa000711.59627354
15Type II diabetes mellitus_Homo sapiens_hsa049301.56533180
16Phenylalanine metabolism_Homo sapiens_hsa003601.54344182
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.50353672
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.42886567
19Viral myocarditis_Homo sapiens_hsa054161.37711356
20Fatty acid metabolism_Homo sapiens_hsa012121.35123242
21Protein digestion and absorption_Homo sapiens_hsa049741.30807643
22Arginine and proline metabolism_Homo sapiens_hsa003301.29105521
23RNA transport_Homo sapiens_hsa030131.26078860
24Phototransduction_Homo sapiens_hsa047441.19744918
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18601868
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18026029
27Salivary secretion_Homo sapiens_hsa049701.17883865
28Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.17739518
29Endocytosis_Homo sapiens_hsa041441.08806665
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07863403
31Adipocytokine signaling pathway_Homo sapiens_hsa049201.05599178
32PPAR signaling pathway_Homo sapiens_hsa033201.03293155
33Renin-angiotensin system_Homo sapiens_hsa046141.00568816
34Calcium signaling pathway_Homo sapiens_hsa040200.96023344
35Morphine addiction_Homo sapiens_hsa050320.95969810
36Arginine biosynthesis_Homo sapiens_hsa002200.94445530
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92262716
38Cardiac muscle contraction_Homo sapiens_hsa042600.89810262
39Primary bile acid biosynthesis_Homo sapiens_hsa001200.89274311
40ABC transporters_Homo sapiens_hsa020100.88570756
41cAMP signaling pathway_Homo sapiens_hsa040240.87420635
42Fat digestion and absorption_Homo sapiens_hsa049750.86246084
43Synaptic vesicle cycle_Homo sapiens_hsa047210.84617421
44Circadian entrainment_Homo sapiens_hsa047130.80391373
45Inositol phosphate metabolism_Homo sapiens_hsa005620.79384934
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78175038
47Nicotine addiction_Homo sapiens_hsa050330.77594303
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77271951
49Glycerolipid metabolism_Homo sapiens_hsa005610.76803673
50Oocyte meiosis_Homo sapiens_hsa041140.76528019
51Influenza A_Homo sapiens_hsa051640.75915729
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.70594076
53Retinol metabolism_Homo sapiens_hsa008300.69807784
54Estrogen signaling pathway_Homo sapiens_hsa049150.69710839
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67161258
56Hedgehog signaling pathway_Homo sapiens_hsa043400.66806968
57Tyrosine metabolism_Homo sapiens_hsa003500.65540401
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64988805
59Glutamatergic synapse_Homo sapiens_hsa047240.62343645
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59581499
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58514006
62Bile secretion_Homo sapiens_hsa049760.58019610
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57556682
64Gastric acid secretion_Homo sapiens_hsa049710.56077887
65Selenocompound metabolism_Homo sapiens_hsa004500.55959250
66Renin secretion_Homo sapiens_hsa049240.53766652
67Insulin secretion_Homo sapiens_hsa049110.49418314
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48159991
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.47793100
70Purine metabolism_Homo sapiens_hsa002300.47730202
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45853365
72Tight junction_Homo sapiens_hsa045300.45019798
73MAPK signaling pathway_Homo sapiens_hsa040100.44503084
74Serotonergic synapse_Homo sapiens_hsa047260.44072470
75Pancreatic secretion_Homo sapiens_hsa049720.40678618
76Cholinergic synapse_Homo sapiens_hsa047250.39722659
77Basal transcription factors_Homo sapiens_hsa030220.35016175
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.33139139
79ECM-receptor interaction_Homo sapiens_hsa045120.32921432
80GABAergic synapse_Homo sapiens_hsa047270.32233705
81VEGF signaling pathway_Homo sapiens_hsa043700.32017345
82Nitrogen metabolism_Homo sapiens_hsa009100.27718892
83mRNA surveillance pathway_Homo sapiens_hsa030150.27604704
84Acute myeloid leukemia_Homo sapiens_hsa052210.26704270
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26240866
86Viral carcinogenesis_Homo sapiens_hsa052030.25231006
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.25169403
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.24649186
89Oxytocin signaling pathway_Homo sapiens_hsa049210.23981397
90Linoleic acid metabolism_Homo sapiens_hsa005910.22720482
91Herpes simplex infection_Homo sapiens_hsa051680.21954891
92Prolactin signaling pathway_Homo sapiens_hsa049170.21407877
93Histidine metabolism_Homo sapiens_hsa003400.20411299
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19693999
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19509437
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.18466875
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18306046
98Long-term potentiation_Homo sapiens_hsa047200.16840523
99Huntingtons disease_Homo sapiens_hsa050160.15707859
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.15177409

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