OR2H2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.69360368
2fusion of sperm to egg plasma membrane (GO:0007342)8.83687021
3chromosome condensation (GO:0030261)7.96233199
4DNA packaging (GO:0006323)7.73027879
5sperm capacitation (GO:0048240)7.59232264
6negative regulation of inclusion body assembly (GO:0090084)7.55578082
7spermatid development (GO:0007286)7.18321771
8single strand break repair (GO:0000012)6.88884846
9plasma membrane fusion (GO:0045026)6.86660718
10protein polyglutamylation (GO:0018095)6.82315388
11microtubule depolymerization (GO:0007019)6.78159348
12rRNA methylation (GO:0031167)6.60473950
13response to pheromone (GO:0019236)6.58772372
14sperm-egg recognition (GO:0035036)6.28198808
15protein targeting to Golgi (GO:0000042)6.26103654
16microtubule polymerization or depolymerization (GO:0031109)6.24361163
17spermatid nucleus differentiation (GO:0007289)6.18206120
18axonemal dynein complex assembly (GO:0070286)6.17630512
19multicellular organism reproduction (GO:0032504)6.05619392
20establishment of protein localization to Golgi (GO:0072600)5.96006215
21binding of sperm to zona pellucida (GO:0007339)5.86797508
22rRNA modification (GO:0000154)5.76661197
23retrograde transport, vesicle recycling within Golgi (GO:0000301)5.74362879
24calcium ion-dependent exocytosis (GO:0017156)5.56399328
25reproduction (GO:0000003)5.54026651
26phosphatidylethanolamine metabolic process (GO:0046337)5.42576829
27establishment of protein localization to mitochondrial membrane (GO:0090151)5.37309386
28spermatogenesis (GO:0007283)5.36398234
29male gamete generation (GO:0048232)5.35970752
30phosphatidylethanolamine biosynthetic process (GO:0006646)5.33092915
31centriole replication (GO:0007099)5.31920780
32regulation of inclusion body assembly (GO:0090083)5.18085897
33chaperone-mediated protein complex assembly (GO:0051131)5.11519916
34regulation of transcription involved in cell fate commitment (GO:0060850)5.08265983
35cell-cell recognition (GO:0009988)5.07574648
36gamete generation (GO:0007276)4.95210575
37sexual reproduction (GO:0019953)4.93041681
38microtubule severing (GO:0051013)4.81848805
39RNA destabilization (GO:0050779)4.74012646
40regulation of centriole replication (GO:0046599)4.60774009
41protein localization to Golgi apparatus (GO:0034067)4.57149128
42cilium or flagellum-dependent cell motility (GO:0001539)4.54974082
43seminiferous tubule development (GO:0072520)4.47768482
44centriole assembly (GO:0098534)4.45960854
45motile cilium assembly (GO:0044458)4.40197658
46single fertilization (GO:0007338)4.35660933
47regulation of cilium movement (GO:0003352)4.34104580
48musculoskeletal movement (GO:0050881)4.21515699
49multicellular organismal movement (GO:0050879)4.21515699
50regulation of Rab GTPase activity (GO:0032313)4.16323912
51positive regulation of Rab GTPase activity (GO:0032851)4.16323912
52epithelial cilium movement (GO:0003351)4.13633946
53pattern specification involved in kidney development (GO:0061004)4.11847149
54germ cell development (GO:0007281)4.01953905
55cilium movement (GO:0003341)4.01469880
56multicellular organismal reproductive process (GO:0048609)3.92208991
57icosanoid secretion (GO:0032309)3.92103589
58arachidonic acid secretion (GO:0050482)3.92103589
59negative regulation of Rho protein signal transduction (GO:0035024)3.86411517
60cellular ketone body metabolic process (GO:0046950)3.72119375
61cellular process involved in reproduction in multicellular organism (GO:0022412)3.72079134
62fertilization (GO:0009566)3.67975259
63chromatin silencing (GO:0006342)3.64097576
64nucleus organization (GO:0006997)3.53216086
65positive regulation of skeletal muscle tissue development (GO:0048643)3.43395400
66regulation of microtubule-based movement (GO:0060632)3.43382576
67behavioral response to nicotine (GO:0035095)3.38128017
68cell wall macromolecule catabolic process (GO:0016998)3.34675833
69cell wall macromolecule metabolic process (GO:0044036)3.31005663
70ketone body metabolic process (GO:1902224)3.25652110
71microtubule nucleation (GO:0007020)3.21890876
72positive regulation of action potential (GO:0045760)3.19485538
73fatty acid derivative transport (GO:1901571)3.13322447
74icosanoid transport (GO:0071715)3.13322447
75nucleosome disassembly (GO:0006337)3.12646752
76protein-DNA complex disassembly (GO:0032986)3.12646752
77tooth mineralization (GO:0034505)3.05496997
78limb development (GO:0060173)3.00186714
79appendage development (GO:0048736)3.00186714
80histone exchange (GO:0043486)3.00102814
81male meiosis I (GO:0007141)2.97996405
82regulation of mesoderm development (GO:2000380)2.95536412
83epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.94039515
84cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.92719770
85negative regulation of organelle assembly (GO:1902116)2.86691097
86glycerol ether metabolic process (GO:0006662)2.84920939
87spinal cord motor neuron differentiation (GO:0021522)2.84867987
88RNA localization (GO:0006403)2.76392115
89multicellular organismal development (GO:0007275)2.73099195
90glomerular epithelial cell development (GO:0072310)2.72866583
91organic cation transport (GO:0015695)2.72040271
92regulation of somitogenesis (GO:0014807)2.70536003
93cell recognition (GO:0008037)2.69983418
94centrosome duplication (GO:0051298)2.68462238
95protein refolding (GO:0042026)2.66566970
96homeostasis of number of cells within a tissue (GO:0048873)2.65905757
97glomerular visceral epithelial cell development (GO:0072015)2.65701861
98DNA conformation change (GO:0071103)2.64642087
99grooming behavior (GO:0007625)2.63917142
100sperm motility (GO:0030317)10.1765768

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.61827111
2EZH2_22144423_ChIP-Seq_EOC_Human4.56439755
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.48701008
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.83473382
5TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.47779312
6POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.47779312
7CTBP1_25329375_ChIP-Seq_LNCAP_Human2.43827755
8* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.37033156
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.25004513
10FUS_26573619_Chip-Seq_HEK293_Human2.23631370
11* CBP_20019798_ChIP-Seq_JUKART_Human1.98003123
12* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.98003123
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85840829
14EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.83220770
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77551971
16ERA_21632823_ChIP-Seq_H3396_Human1.76148310
17VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.68829291
18SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68514956
19UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.67746285
20EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.66282544
21TDRD3_21172665_ChIP-Seq_MCF-7_Human1.64197438
22CTCF_27219007_Chip-Seq_Bcells_Human1.63896446
23MYC_19829295_ChIP-Seq_ESCs_Human1.60781616
24RAC3_21632823_ChIP-Seq_H3396_Human1.59914217
25EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.59379294
26TAF2_19829295_ChIP-Seq_ESCs_Human1.59227401
27YY1_22570637_ChIP-Seq_MALME-3M_Human1.59004886
28RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.55270203
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54400872
30SMAD3_21741376_ChIP-Seq_EPCs_Human1.54060896
31SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52923775
32SMAD4_21741376_ChIP-Seq_EPCs_Human1.52320462
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.50066040
34P53_22127205_ChIP-Seq_FIBROBLAST_Human1.49179410
35NANOG_20526341_ChIP-Seq_ESCs_Human1.48914772
36ER_23166858_ChIP-Seq_MCF-7_Human1.48374738
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.48204875
38P300_19829295_ChIP-Seq_ESCs_Human1.46212423
39E2F1_20622854_ChIP-Seq_HELA_Human1.44864839
40GATA1_26923725_Chip-Seq_HPCs_Mouse1.41737533
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41339120
42SMAD3_21741376_ChIP-Seq_ESCs_Human1.40818746
43TP53_18474530_ChIP-ChIP_U2OS_Human1.39944263
44P68_20966046_ChIP-Seq_HELA_Human1.39685083
45CTCF_20526341_ChIP-Seq_ESCs_Human1.39065087
46RUNX1_26923725_Chip-Seq_HPCs_Mouse1.38985435
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.38902663
48WDR5_24793694_ChIP-Seq_LNCAP_Human1.38646057
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.37596799
50AUTS2_25519132_ChIP-Seq_293T-REX_Human1.36618372
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36200075
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.35685589
53SMC4_20622854_ChIP-Seq_HELA_Human1.34568014
54REST_21632747_ChIP-Seq_MESCs_Mouse1.33357102
55DROSHA_22980978_ChIP-Seq_HELA_Human1.33293072
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32474335
57TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31722232
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30944275
59AR_25329375_ChIP-Seq_VCAP_Human1.30915073
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30785033
61PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.30200680
62BCL6_27268052_Chip-Seq_Bcells_Human1.25592373
63ZNF274_21170338_ChIP-Seq_K562_Hela1.24455605
64RBPJ_21746931_ChIP-Seq_IB4_Human1.23239032
65IRF1_19129219_ChIP-ChIP_H3396_Human1.20562857
66CBX2_22325352_ChIP-Seq_293T-Rex_Human1.20153082
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19217834
68TAF15_26573619_Chip-Seq_HEK293_Human1.19002002
69PHF8_20622854_ChIP-Seq_HELA_Human1.18346257
70* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16484770
71SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16410401
72RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15890519
73EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15890519
74P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.15644725
75JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15525783
76ETV1_20927104_ChIP-Seq_GIST48_Human1.15360321
77HNFA_21074721_ChIP-Seq_CACO-2_Human1.14940628
78ERG_20517297_ChIP-Seq_VCAP_Human1.14345248
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13651478
80BCOR_27268052_Chip-Seq_Bcells_Human1.13270758
81NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13249574
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12880850
83SMAD4_21741376_ChIP-Seq_HESCs_Human1.12072395
84OCT4_20526341_ChIP-Seq_ESCs_Human1.11061205
85RUNX2_22187159_ChIP-Seq_PCA_Human1.10397121
86REST_18959480_ChIP-ChIP_MESCs_Mouse1.10342921
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09286769
88CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09060879
89P53_21459846_ChIP-Seq_SAOS-2_Human1.08982836
90P300_27268052_Chip-Seq_Bcells_Human1.08185755
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.06815768
92KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.06715826
93SA1_27219007_Chip-Seq_Bcells_Human1.06453341
94GATA3_21878914_ChIP-Seq_MCF-7_Human1.05536563
95CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.04842744
96SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04664958
97E2F1_17053090_ChIP-ChIP_MCF-7_Human1.04309940
98TP63_22573176_ChIP-Seq_HFKS_Human1.02574545
99LXR_22292898_ChIP-Seq_THP-1_Human1.01021820
100FOXH1_21741376_ChIP-Seq_EPCs_Human1.00780226

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.59412401
2MP0005377_hearing/vestibular/ear_phenot4.86729522
3MP0003878_abnormal_ear_physiology4.86729522
4MP0005670_abnormal_white_adipose3.87734988
5MP0003698_abnormal_male_reproductive3.30252304
6MP0001929_abnormal_gametogenesis2.94060057
7MP0003646_muscle_fatigue2.87926766
8MP0001348_abnormal_lacrimal_gland2.82871817
9MP0004233_abnormal_muscle_weight2.59969363
10MP0002735_abnormal_chemical_nociception2.35889864
11MP0004742_abnormal_vestibular_system2.28368230
12MP0006292_abnormal_olfactory_placode2.15484782
13MP0002249_abnormal_larynx_morphology1.88947872
14MP0002161_abnormal_fertility/fecundity1.88425281
15MP0003879_abnormal_hair_cell1.85764810
16MP0004859_abnormal_synaptic_plasticity1.84526370
17MP0001486_abnormal_startle_reflex1.79553066
18MP0001485_abnormal_pinna_reflex1.72726405
19MP0005423_abnormal_somatic_nervous1.68282371
20MP0001440_abnormal_grooming_behavior1.63689595
21MP0009053_abnormal_anal_canal1.62577913
22MP0002837_dystrophic_cardiac_calcinosis1.61831128
23MP0003718_maternal_effect1.59236738
24MP0002210_abnormal_sex_determination1.52466863
25MP0001984_abnormal_olfaction1.48867438
26MP0005084_abnormal_gallbladder_morpholo1.44610161
27MP0002822_catalepsy1.39987855
28MP0002282_abnormal_trachea_morphology1.35739339
29MP0002733_abnormal_thermal_nociception1.34677072
30MP0003011_delayed_dark_adaptation1.33550315
31MP0005367_renal/urinary_system_phenotyp1.33115409
32MP0000516_abnormal_urinary_system1.33115409
33MP0000566_synostosis1.30663447
34MP0001293_anophthalmia1.29946921
35MP0001963_abnormal_hearing_physiology1.28661093
36MP0001986_abnormal_taste_sensitivity1.25457647
37MP0009745_abnormal_behavioral_response1.24107745
38MP0001968_abnormal_touch/_nociception1.23399347
39MP0000026_abnormal_inner_ear1.22594149
40MP0001145_abnormal_male_reproductive1.18360201
41MP0002638_abnormal_pupillary_reflex1.18211958
42MP0002272_abnormal_nervous_system1.15626757
43MP0002928_abnormal_bile_duct1.15488210
44MP0000678_abnormal_parathyroid_gland1.15421481
45MP0002132_abnormal_respiratory_system1.15019846
46MP0000653_abnormal_sex_gland1.12712197
47MP0002067_abnormal_sensory_capabilities1.11913892
48MP0003136_yellow_coat_color1.10590662
49MP0000955_abnormal_spinal_cord1.10503098
50MP0008058_abnormal_DNA_repair1.05740782
51MP0003880_abnormal_central_pattern1.04916485
52MP0003119_abnormal_digestive_system1.03078920
53MP0001905_abnormal_dopamine_level1.01287336
54MP0002572_abnormal_emotion/affect_behav0.99823963
55MP0000049_abnormal_middle_ear0.99676171
56MP0000534_abnormal_ureter_morphology0.95586347
57MP0003635_abnormal_synaptic_transmissio0.94877071
58MP0002557_abnormal_social/conspecific_i0.94460850
59MP0002734_abnormal_mechanical_nocicepti0.93986472
60MP0001970_abnormal_pain_threshold0.92642967
61MP0009379_abnormal_foot_pigmentation0.92474748
62MP0002229_neurodegeneration0.92039033
63MP0003959_abnormal_lean_body0.91697910
64MP0004142_abnormal_muscle_tone0.91226260
65MP0008877_abnormal_DNA_methylation0.90582950
66MP0005551_abnormal_eye_electrophysiolog0.89855149
67MP0004085_abnormal_heartbeat0.86028458
68MP0010030_abnormal_orbit_morphology0.84841178
69MP0008775_abnormal_heart_ventricle0.83695153
70MP0008007_abnormal_cellular_replicative0.83173306
71MP0008789_abnormal_olfactory_epithelium0.82532563
72MP0002064_seizures0.81161753
73MP0005248_abnormal_Harderian_gland0.80497559
74MP0002653_abnormal_ependyma_morphology0.79892161
75MP0008569_lethality_at_weaning0.78038345
76MP0002184_abnormal_innervation0.77525320
77MP0004510_myositis0.77106299
78MP0009115_abnormal_fat_cell0.75677268
79MP0002234_abnormal_pharynx_morphology0.74871262
80MP0005083_abnormal_biliary_tract0.74742627
81MP0005379_endocrine/exocrine_gland_phen0.74215551
82MP0009046_muscle_twitch0.73698014
83MP0004957_abnormal_blastocyst_morpholog0.72446610
84MP0005253_abnormal_eye_physiology0.72327153
85MP0002063_abnormal_learning/memory/cond0.71983421
86MP0005666_abnormal_adipose_tissue0.70807243
87MP0002752_abnormal_somatic_nervous0.68283969
88MP0005499_abnormal_olfactory_system0.66356881
89MP0005394_taste/olfaction_phenotype0.66356881
90MP0001765_abnormal_ion_homeostasis0.66141472
91MP0002882_abnormal_neuron_morphology0.64402664
92MP0002127_abnormal_cardiovascular_syste0.63874376
93MP0005391_vision/eye_phenotype0.63668997
94MP0003077_abnormal_cell_cycle0.61022477
95MP0003638_abnormal_response/metabolism_0.60997173
96MP0003861_abnormal_nervous_system0.60867059
97MP0003137_abnormal_impulse_conducting0.59643836
98MP0003937_abnormal_limbs/digits/tail_de0.59499502
99MP0002138_abnormal_hepatobiliary_system0.59224859
100MP0003693_abnormal_embryo_hatching0.56414785

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)5.96560208
2Tubulointerstitial nephritis (HP:0001970)5.28425374
3Bony spicule pigmentary retinopathy (HP:0007737)5.21302020
4Chronic hepatic failure (HP:0100626)4.52876375
5Dynein arm defect of respiratory motile cilia (HP:0012255)4.40734215
6Absent/shortened dynein arms (HP:0200106)4.40734215
7Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.28060619
8Abnormal respiratory motile cilium physiology (HP:0012261)4.23873544
9Abnormal rod and cone electroretinograms (HP:0008323)4.23106103
10Abnormal ciliary motility (HP:0012262)4.18264763
11Progressive cerebellar ataxia (HP:0002073)4.04776927
12Hyperkalemia (HP:0002153)3.99383494
13Aplasia/Hypoplasia of the sacrum (HP:0008517)3.84041040
14Type 2 muscle fiber atrophy (HP:0003554)3.76876964
15Myokymia (HP:0002411)3.74991720
16Attenuation of retinal blood vessels (HP:0007843)3.72376319
17Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.67312424
18Muscle fiber atrophy (HP:0100295)3.66278611
19Infertility (HP:0000789)3.58554305
20Resting tremor (HP:0002322)3.48441418
21Asymmetric septal hypertrophy (HP:0001670)3.29010610
22Male infertility (HP:0003251)3.28748613
23Abnormal respiratory motile cilium morphology (HP:0005938)3.23088762
24Abnormal respiratory epithelium morphology (HP:0012253)3.23088762
25Aplasia/Hypoplasia of the earlobes (HP:0009906)3.08102131
26Menstrual irregularities (HP:0000858)2.99394099
27Bell-shaped thorax (HP:0001591)2.97958594
28Nephronophthisis (HP:0000090)2.95167425
29Cone-rod dystrophy (HP:0000548)2.91764945
30Abnormality of the neuromuscular junction (HP:0003398)2.91386173
31Fatigable weakness (HP:0003473)2.91386173
32Nasal polyposis (HP:0100582)2.82782659
33Abnormality of cochlea (HP:0000375)2.74596406
34Impulsivity (HP:0100710)2.73239749
35Renovascular hypertension (HP:0100817)2.63687531
36Facial shape deformation (HP:0011334)2.60207808
37Potter facies (HP:0002009)2.60207808
38Abnormality of macular pigmentation (HP:0008002)2.57540360
39Abnormality of the aortic arch (HP:0012303)2.56789895
40Absent rod-and cone-mediated responses on ERG (HP:0007688)2.54456314
41Hypoalphalipoproteinemia (HP:0003233)2.49643074
42Abnormal spermatogenesis (HP:0008669)2.48299340
43Abnormality of the renal medulla (HP:0100957)2.46664824
44Amelogenesis imperfecta (HP:0000705)2.40574214
45Esophageal atresia (HP:0002032)2.40148777
46Poor suck (HP:0002033)2.40007910
47Enlarged epiphyses (HP:0010580)2.39429909
48Hypoplastic ischia (HP:0003175)2.39148104
49Abnormality of dental color (HP:0011073)2.36267898
50Weak cry (HP:0001612)2.34500250
51Stage 5 chronic kidney disease (HP:0003774)2.32278310
52Abnormality of the ischium (HP:0003174)2.30147063
53Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.29596431
54Short 4th metacarpal (HP:0010044)2.29596431
55Optic nerve hypoplasia (HP:0000609)2.28893960
56Renal dysplasia (HP:0000110)2.28736337
57Tubulointerstitial abnormality (HP:0001969)2.26632716
58Rhinitis (HP:0012384)2.26174401
59Abnormality of the nasal mucosa (HP:0000433)2.25634404
60Progressive sensorineural hearing impairment (HP:0000408)2.20249932
61Subcapsular cataract (HP:0000523)2.19509867
62Postural instability (HP:0002172)2.19348372
63Hyperthyroidism (HP:0000836)2.15136830
64Hypoplasia of the thymus (HP:0000778)2.15021705
65Morphological abnormality of the inner ear (HP:0011390)2.14776250
66Truncal obesity (HP:0001956)2.13696298
67Renal Fanconi syndrome (HP:0001994)2.12389804
68Ventricular tachycardia (HP:0004756)2.11443498
69Abnormality of the 4th metacarpal (HP:0010012)2.11241237
70Chronic bronchitis (HP:0004469)2.09061901
71Nonprogressive disorder (HP:0003680)2.08700019
72Osteomalacia (HP:0002749)2.05383562
73Short femoral neck (HP:0100864)2.05050210
74Azoospermia (HP:0000027)2.04181982
75Abnormality of potassium homeostasis (HP:0011042)2.00562065
76Failure to thrive in infancy (HP:0001531)2.00096875
77Decreased muscle mass (HP:0003199)1.98622216
78Rib fusion (HP:0000902)1.96329796
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.95294497
80Anophthalmia (HP:0000528)1.93681189
81Abnormal urine output (HP:0012590)1.89019214
82Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.88291901
83Decreased central vision (HP:0007663)1.86168527
84Intellectual disability, moderate (HP:0002342)1.84731267
85Synostosis of carpal bones (HP:0005048)1.81281991
86Amblyopia (HP:0000646)1.80828882
87Genetic anticipation (HP:0003743)1.80332121
88Atonic seizures (HP:0010819)1.78253810
89Obsessive-compulsive behavior (HP:0000722)1.77992714
90Abnormality of renal excretion (HP:0011036)1.77124554
91Abnormality of renal resorption (HP:0011038)1.77080887
92Abnormality of the costochondral junction (HP:0000919)1.72945198
93Portal hypertension (HP:0001409)1.71606923
94Fibular hypoplasia (HP:0003038)1.71599872
95Gastrointestinal atresia (HP:0002589)1.69864787
96Hypolipoproteinemia (HP:0010981)1.69517875
97Sclerocornea (HP:0000647)1.68246544
98Abnormality of the parathyroid morphology (HP:0011766)1.66915231
99Increased purine levels (HP:0004368)1.65367755
100Hyperuricemia (HP:0002149)1.65367755

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.57923695
2MAPK153.82127325
3TESK13.70944221
4TSSK63.51114717
5DDR23.48207813
6BRD43.26220898
7INSRR3.21458535
8PLK23.08301928
9MAP4K22.93196797
10STK38L2.66479953
11CDC72.57112446
12PNCK2.46585346
13STK382.42513048
14PRKD32.00699071
15PIK3CA1.99678922
16CAMK1G1.92307697
17DYRK1B1.68961834
18TYRO31.59278282
19MAP3K41.48232348
20WNK11.43780335
21BMPR1B1.38355786
22NME11.32883624
23PIK3CG1.31417269
24TESK21.24785686
25TIE11.15646669
26MAP2K71.12206536
27CAMK1D1.11051092
28NEK61.00780811
29MARK10.98065810
30RPS6KA20.96039529
31WNK40.92420411
32MAP3K110.92093448
33LATS20.91177094
34PDK10.90823265
35CDK70.90820192
36PRKCG0.85919060
37CDK120.84988733
38PDPK10.82595658
39SIK20.80869825
40CDK30.78712226
41CASK0.76999029
42MAP3K90.75672473
43CAMK10.74469789
44UHMK10.74141517
45DYRK30.71081307
46FGFR20.64061113
47MST1R0.59899652
48RPS6KA10.58968399
49VRK10.58708224
50PRKG10.54364635
51NTRK30.54252833
52CHEK10.52096955
53AKT30.51908413
54CDK20.51143991
55NTRK20.49971523
56GSK3B0.49836617
57PLK10.49824409
58FRK0.49663125
59DYRK20.48727990
60CDK10.47311528
61TAF10.46883585
62MAPKAPK50.46655594
63RPS6KL10.46022087
64RPS6KC10.46022087
65RPS6KA60.45289208
66TRIM280.44849994
67MARK20.42581655
68BRSK10.42572390
69MTOR0.42443556
70MAPK10.41418052
71MAPK140.40366197
72PRKCZ0.38953245
73PTK2B0.38428958
74SGK2230.37887630
75SGK4940.37887630
76PRKG20.37013723
77MAPK100.31443194
78STK390.31251349
79MAPK80.31131829
80PIM20.29895537
81CHEK20.28620062
82CAMK40.28322197
83TNIK0.28235639
84ERBB40.27848210
85MINK10.26336893
86SGK10.25782704
87BRAF0.25316581
88BRSK20.25240421
89PRKCE0.24348078
90PRKACA0.24045656
91AKT10.21767188
92SGK20.20541355
93ROCK10.20273989
94OBSCN0.20015164
95PRKCB0.19987428
96MUSK0.19584805
97AURKA0.18861014
98CDK50.18765122
99RPS6KA30.18498953
100PLK30.18196956

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.61084480
2Fatty acid biosynthesis_Homo sapiens_hsa000614.23771126
3* Olfactory transduction_Homo sapiens_hsa047402.89148290
4Nicotine addiction_Homo sapiens_hsa050332.80982180
5Cardiac muscle contraction_Homo sapiens_hsa042602.66080210
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.51939165
7Fanconi anemia pathway_Homo sapiens_hsa034602.28542789
8Taste transduction_Homo sapiens_hsa047422.13349304
9Butanoate metabolism_Homo sapiens_hsa006502.02400826
10Morphine addiction_Homo sapiens_hsa050321.91196946
11RNA transport_Homo sapiens_hsa030131.86846060
12GABAergic synapse_Homo sapiens_hsa047271.75863064
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.73720996
14Huntingtons disease_Homo sapiens_hsa050161.71257986
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.69254362
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.59970675
17Type II diabetes mellitus_Homo sapiens_hsa049301.54476436
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52948614
19Homologous recombination_Homo sapiens_hsa034401.46844783
20Nitrogen metabolism_Homo sapiens_hsa009101.45020007
21DNA replication_Homo sapiens_hsa030301.43937046
22Hedgehog signaling pathway_Homo sapiens_hsa043401.34634682
23Phototransduction_Homo sapiens_hsa047441.31231201
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.29735662
25Antigen processing and presentation_Homo sapiens_hsa046121.26584144
26Synaptic vesicle cycle_Homo sapiens_hsa047211.25194124
27Glutamatergic synapse_Homo sapiens_hsa047241.25169583
28Fatty acid metabolism_Homo sapiens_hsa012121.19828265
29Circadian entrainment_Homo sapiens_hsa047131.18942412
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.18891281
31RNA polymerase_Homo sapiens_hsa030201.16820919
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.11147243
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10925977
34Purine metabolism_Homo sapiens_hsa002301.09567836
35Calcium signaling pathway_Homo sapiens_hsa040201.05328516
36Fatty acid degradation_Homo sapiens_hsa000711.04086508
37Ribosome_Homo sapiens_hsa030100.99772866
38Arginine and proline metabolism_Homo sapiens_hsa003300.97589853
39Pyrimidine metabolism_Homo sapiens_hsa002400.97313235
40Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96449090
41Cholinergic synapse_Homo sapiens_hsa047250.94336671
42Parkinsons disease_Homo sapiens_hsa050120.94303525
43Dorso-ventral axis formation_Homo sapiens_hsa043200.92188210
44Base excision repair_Homo sapiens_hsa034100.91807051
45Basal cell carcinoma_Homo sapiens_hsa052170.91360372
46Serotonergic synapse_Homo sapiens_hsa047260.89058158
47Adipocytokine signaling pathway_Homo sapiens_hsa049200.88941405
48Estrogen signaling pathway_Homo sapiens_hsa049150.88373011
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87493726
50cAMP signaling pathway_Homo sapiens_hsa040240.84666519
51Spliceosome_Homo sapiens_hsa030400.82824970
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82579062
53Oxidative phosphorylation_Homo sapiens_hsa001900.81967148
54Vitamin B6 metabolism_Homo sapiens_hsa007500.81565912
55Salivary secretion_Homo sapiens_hsa049700.79259771
56Oocyte meiosis_Homo sapiens_hsa041140.78971334
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.77874794
58Endocytosis_Homo sapiens_hsa041440.76621930
59MAPK signaling pathway_Homo sapiens_hsa040100.75731242
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74993289
61Insulin secretion_Homo sapiens_hsa049110.69456079
62Selenocompound metabolism_Homo sapiens_hsa004500.68312396
63Protein digestion and absorption_Homo sapiens_hsa049740.66282628
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62877414
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62080851
66Hippo signaling pathway_Homo sapiens_hsa043900.61593546
67Amphetamine addiction_Homo sapiens_hsa050310.61217060
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61134852
69Inositol phosphate metabolism_Homo sapiens_hsa005620.60606244
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60126936
71Dopaminergic synapse_Homo sapiens_hsa047280.59121185
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58444667
73Phenylalanine metabolism_Homo sapiens_hsa003600.55817398
74Type I diabetes mellitus_Homo sapiens_hsa049400.55249285
75Gastric acid secretion_Homo sapiens_hsa049710.54826927
76RNA degradation_Homo sapiens_hsa030180.54189229
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52279057
78Glycerolipid metabolism_Homo sapiens_hsa005610.52151602
79Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52008207
80Wnt signaling pathway_Homo sapiens_hsa043100.49287142
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46214047
82Nucleotide excision repair_Homo sapiens_hsa034200.45866416
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45115378
84Alzheimers disease_Homo sapiens_hsa050100.45058352
85mRNA surveillance pathway_Homo sapiens_hsa030150.44229866
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44045249
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43778864
88Renin secretion_Homo sapiens_hsa049240.41966834
89Retinol metabolism_Homo sapiens_hsa008300.40872762
90Long-term potentiation_Homo sapiens_hsa047200.40417863
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39635882
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39273488
93Oxytocin signaling pathway_Homo sapiens_hsa049210.38841472
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38812873
95Metabolic pathways_Homo sapiens_hsa011000.34193711
96Dilated cardiomyopathy_Homo sapiens_hsa054140.33160718
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31021856
98Tight junction_Homo sapiens_hsa045300.28490864
99Thyroid hormone synthesis_Homo sapiens_hsa049180.28271632
100Basal transcription factors_Homo sapiens_hsa030220.28261974

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