ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of fibrinolysis (GO:0051918)	6.70706480
2	complement activation, classical pathway (GO:0006958)	6.59872057
3	regulation of fibrinolysis (GO:0051917)	6.42697077
4	drug catabolic process (GO:0042737)	6.27658583
5	exogenous drug catabolic process (GO:0042738)	6.22533909
6	urea metabolic process (GO:0019627)	5.72812383
7	complement activation (GO:0006956)	5.71575547
8	regulation of protein activation cascade (GO:2000257)	5.71192727
9	glyoxylate metabolic process (GO:0046487)	5.60989727
10	peptidyl-glutamic acid carboxylation (GO:0017187)	5.55408905
11	protein carboxylation (GO:0018214)	5.55408905
12	fibrinolysis (GO:0042730)	5.55365606
13	negative regulation of sterol transport (GO:0032372)	5.53802604
14	negative regulation of cholesterol transport (GO:0032375)	5.53802604
15	complement activation, alternative pathway (GO:0006957)	5.49430330
16	regulation of complement activation (GO:0030449)	5.48248745
17	protein activation cascade (GO:0072376)	5.42217633
18	nitrogen cycle metabolic process (GO:0071941)	5.26089644
19	L-phenylalanine catabolic process (GO:0006559)	5.25975749
20	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.25975749
21	urea cycle (GO:0000050)	5.25729078
22	phospholipid efflux (GO:0033700)	5.19552495
23	epoxygenase P450 pathway (GO:0019373)	5.15150027
24	cellular glucuronidation (GO:0052695)	5.10481844
25	L-phenylalanine metabolic process (GO:0006558)	4.96682085
26	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.96682085
27	uronic acid metabolic process (GO:0006063)	4.92778095
28	glucuronate metabolic process (GO:0019585)	4.92778095
29	ethanol oxidation (GO:0006069)	4.83534315
30	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	4.73549369
31	regulation of cholesterol esterification (GO:0010872)	4.71412857
32	drug metabolic process (GO:0017144)	4.45541619
33	protein-lipid complex remodeling (GO:0034368)	4.42836430
34	macromolecular complex remodeling (GO:0034367)	4.42836430
35	plasma lipoprotein particle remodeling (GO:0034369)	4.42836430
36	phenylpropanoid metabolic process (GO:0009698)	4.36794976
37	regulation of triglyceride catabolic process (GO:0010896)	4.35698306
38	blood coagulation, intrinsic pathway (GO:0007597)	4.32692856
39	very-low-density lipoprotein particle assembly (GO:0034379)	4.30204623
40	positive regulation of triglyceride lipase activity (GO:0061365)	4.29653716
41	positive regulation of lipoprotein lipase activity (GO:0051006)	4.29653716
42	regulation of apoptotic cell clearance (GO:2000425)	4.28648055
43	negative regulation of blood coagulation (GO:0030195)	4.28629186
44	negative regulation of hemostasis (GO:1900047)	4.28629186
45	regulation of plasminogen activation (GO:0010755)	4.26425305
46	high-density lipoprotein particle remodeling (GO:0034375)	4.16392957
47	acute-phase response (GO:0006953)	3.95359649
48	negative regulation of coagulation (GO:0050819)	3.94765196
49	alkaloid metabolic process (GO:0009820)	3.91703051
50	positive regulation of blood coagulation (GO:0030194)	3.91180525
51	positive regulation of hemostasis (GO:1900048)	3.91180525
52	aromatic amino acid family catabolic process (GO:0009074)	3.90164234
53	omega-hydroxylase P450 pathway (GO:0097267)	3.88157190
54	ethanol metabolic process (GO:0006067)	3.83830848
55	hormone catabolic process (GO:0042447)	3.82224120
56	plasma lipoprotein particle assembly (GO:0034377)	3.81633858
57	low-density lipoprotein particle remodeling (GO:0034374)	3.80846936
58	negative regulation of wound healing (GO:0061045)	3.78915382
59	bile acid metabolic process (GO:0008206)	3.77161149
60	regulation of humoral immune response (GO:0002920)	3.74850719
61	cholesterol efflux (GO:0033344)	3.72519922
62	arginine metabolic process (GO:0006525)	3.70430073
63	positive regulation of respiratory burst (GO:0060267)	3.68974141
64	positive regulation of coagulation (GO:0050820)	3.65033766
65	bile acid and bile salt transport (GO:0015721)	3.65005450
66	acylglycerol homeostasis (GO:0055090)	3.61510385
67	triglyceride homeostasis (GO:0070328)	3.61510385
68	fat-soluble vitamin biosynthetic process (GO:0042362)	3.60841078
69	serine family amino acid catabolic process (GO:0009071)	3.58001547
70	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	3.55740763
71	oxidative demethylation (GO:0070989)	3.53934958
72	negative regulation of lipase activity (GO:0060192)	3.53105841
73	primary alcohol catabolic process (GO:0034310)	3.52965463
74	bile acid biosynthetic process (GO:0006699)	3.49233342
75	plasma lipoprotein particle organization (GO:0071827)	3.49184434
76	protein-lipid complex assembly (GO:0065005)	3.46220377
77	lipoprotein metabolic process (GO:0042157)	3.45498119
78	polyketide metabolic process (GO:0030638)	3.44856618
79	doxorubicin metabolic process (GO:0044598)	3.44856618
80	daunorubicin metabolic process (GO:0044597)	3.44856618
81	reverse cholesterol transport (GO:0043691)	3.43699530
82	arginine catabolic process (GO:0006527)	3.43083095
83	flavonoid metabolic process (GO:0009812)	3.38311583
84	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	3.37628542
85	regulation of dendritic cell antigen processing and presentation (GO:0002604)	3.35332697
86	protein-lipid complex subunit organization (GO:0071825)	3.31834622
87	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	3.24847087
88	negative regulation of fatty acid biosynthetic process (GO:0045717)	3.23342340
89	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.20495058
90	intestinal absorption (GO:0050892)	3.18244323
91	negative regulation of lipid transport (GO:0032369)	3.16836328
92	antigen processing and presentation of endogenous antigen (GO:0019883)	3.15932277
93	intestinal cholesterol absorption (GO:0030299)	3.14070931
94	plasma lipoprotein particle clearance (GO:0034381)	3.12223491
95	acute inflammatory response (GO:0002526)	3.11704945
96	S-adenosylmethionine metabolic process (GO:0046500)	3.03169233
97	aminoglycoside antibiotic metabolic process (GO:0030647)	3.02280881
98	regulation of lipoprotein particle clearance (GO:0010984)	2.99314489
99	amino-acid betaine metabolic process (GO:0006577)	2.97034361
100	negative regulation of protein activation cascade (GO:2000258)	2.96508919

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	7.03561041
2	RXR_22158963_ChIP-Seq_LIVER_Mouse	4.57830560
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	4.38330435
4	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.15730152
5	PPARA_22158963_ChIP-Seq_LIVER_Mouse	4.00133792
6	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.99021864
7	LXR_22158963_ChIP-Seq_LIVER_Mouse	3.59553852
8	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.51108654
9	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	3.33649295
10	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	2.71194698
11	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.68441312
12	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.51135479
13	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.46114166
14	LXR_22292898_ChIP-Seq_THP-1_Human	2.27292546
15	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.27200829
16	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.12740778
17	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.09892065
18	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.89558905
19	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.83658914
20	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.81876492
21	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.77846495
22	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.68570979
23	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.66635491
24	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.59196960
25	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.54810404
26	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.53379320
27	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.52170067
28	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.47912091
29	RACK7_27058665_Chip-Seq_MCF-7_Human	1.41353528
30	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.40134789
31	CLOCK_20551151_ChIP-Seq_293T_Human	1.38876142
32	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.38632675
33	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.35399657
34	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.30250599
35	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.29267608
36	GATA6_25053715_ChIP-Seq_YYC3_Human	1.26161092
37	GATA4_25053715_ChIP-Seq_YYC3_Human	1.25514357
38	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.19712379
39	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.19605195
40	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.17430687
41	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.17126786
42	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.17000555
43	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.16950604
44	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.16434959
45	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.16131113
46	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.15291960
47	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.15198226
48	VDR_21846776_ChIP-Seq_THP-1_Human	1.15113025
49	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.12153081
50	SOX2_20726797_ChIP-Seq_SW620_Human	1.09034732
51	SMC4_20622854_ChIP-Seq_HELA_Human	1.08885467
52	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.07967094
53	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.07282175
54	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.06878847
55	BCOR_27268052_Chip-Seq_Bcells_Human	1.05932221
56	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.05867016
57	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.04930763
58	BCL6_27268052_Chip-Seq_Bcells_Human	1.04640726
59	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.02886665
60	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.02047296
61	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.00353214
62	IRF8_27001747_Chip-Seq_BMDM_Mouse	0.99804320
63	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.98632124
64	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.98369283
65	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.97653186
66	SA1_27219007_Chip-Seq_Bcells_Human	0.96538784
67	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.96451105
68	CTCF_27219007_Chip-Seq_Bcells_Human	0.95514961
69	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.95047321
70	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.93965727
71	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.93421483
72	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.92195980
73	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.91225525
74	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.91189779
75	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.90544288
76	VDR_24763502_ChIP-Seq_THP-1_Human	0.89277439
77	TCF7_22412390_ChIP-Seq_EML_Mouse	0.87527667
78	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.87392288
79	P68_20966046_ChIP-Seq_HELA_Human	0.87229982
80	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.87005085
81	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.86126077
82	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.82933939
83	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.82174757
84	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.82058731
85	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.81666607
86	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.81569497
87	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.80754144
88	GATA1_19941826_ChIP-Seq_K562_Human	0.80230799
89	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.80205430
90	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.79371820
91	E2F1_20622854_ChIP-Seq_HELA_Human	0.78843167
92	GATA2_22383799_ChIP-Seq_G1ME_Mouse	0.78770905
93	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.78247430
94	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.78043451
95	TP63_22573176_ChIP-Seq_HFKS_Human	0.77662425
96	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.77235053
97	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.77061903
98	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.76712831
99	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.76317272
100	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.76062974

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	8.02857824
2	MP0005360_urolithiasis	5.75517654
3	MP0002138_abnormal_hepatobiliary_system	4.65805141
4	MP0005365_abnormal_bile_salt	4.54050241
5	MP0005085_abnormal_gallbladder_physiolo	4.24839527
6	MP0003195_calcinosis	3.70920660
7	MP0009840_abnormal_foam_cell	3.68259872
8	MP0001666_abnormal_nutrient_absorption	3.18609177
9	MP0008875_abnormal_xenobiotic_pharmacok	2.81567989
10	MP0003252_abnormal_bile_duct	2.46341547
11	MP0003868_abnormal_feces_composition	2.37690862
12	MP0000685_abnormal_immune_system	2.32023488
13	MP0010329_abnormal_lipoprotein_level	2.15604213
14	MP0005451_abnormal_body_composition	2.08120822
15	MP0003806_abnormal_nucleotide_metabolis	1.98784608
16	MP0003191_abnormal_cellular_cholesterol	1.93930932
17	MP0002254_reproductive_system_inflammat	1.81509287
18	MP0010155_abnormal_intestine_physiology	1.78835045
19	MP0005332_abnormal_amino_acid	1.77946238
20	MP0004510_myositis	1.77848587
21	MP0003724_increased_susceptibility_to	1.71186861
22	MP0002876_abnormal_thyroid_physiology	1.68835315
23	MP0000604_amyloidosis	1.66013866
24	MP0003436_decreased_susceptibility_to	1.62834846
25	MP0009785_altered_susceptibility_to	1.62098739
26	MP0001873_stomach_inflammation	1.60744076
27	MP0000609_abnormal_liver_physiology	1.53969304
28	MP0001790_abnormal_immune_system	1.50061583
29	MP0005387_immune_system_phenotype	1.50061583
30	MP0001835_abnormal_antigen_presentation	1.47859440
31	MP0004019_abnormal_vitamin_homeostasis	1.41383612
32	MP0005025_abnormal_response_to	1.38852625
33	MP0005058_abnormal_lysosome_morphology	1.34658329
34	MP0004858_abnormal_nervous_system	1.29826391
35	MP0005166_decreased_susceptibility_to	1.29581708
36	MP0001764_abnormal_homeostasis	1.26766441
37	MP0002118_abnormal_lipid_homeostasis	1.23278370
38	MP0008469_abnormal_protein_level	1.22721908
39	MP0010234_abnormal_vibrissa_follicle	1.20959990
40	MP0005319_abnormal_enzyme/_coenzyme	1.18762140
41	MP0003303_peritoneal_inflammation	1.17435162
42	MP0009643_abnormal_urine_homeostasis	1.17262938
43	MP0003300_gastrointestinal_ulcer	1.17062254
44	MP0005671_abnormal_response_to	1.14414390
45	MP0000566_synostosis	1.13384661
46	MP0003329_amyloid_beta_deposits	1.06517759
47	MP0001800_abnormal_humoral_immune	1.05761126
48	MP0004782_abnormal_surfactant_physiolog	1.04845915
49	MP0004947_skin_inflammation	1.04267615
50	MP0000858_altered_metastatic_potential	1.01692833
51	MP0003075_altered_response_to	1.00561441
52	MP0001845_abnormal_inflammatory_respons	0.99547702
53	MP0001533_abnormal_skeleton_physiology	0.96784757
54	MP0005023_abnormal_wound_healing	0.95210101
55	MP0003866_abnormal_defecation	0.94503220
56	MP0002148_abnormal_hypersensitivity_rea	0.93741314
57	MP0003183_abnormal_peptide_metabolism	0.93296567
58	MP0010368_abnormal_lymphatic_system	0.93202244
59	MP0005584_abnormal_enzyme/coenzyme_acti	0.92794711
60	MP0006082_CNS_inflammation	0.90601929
61	MP0009333_abnormal_splenocyte_physiolog	0.90127803
62	MP0004264_abnormal_extraembryonic_tissu	0.87704056
63	MP0002419_abnormal_innate_immunity	0.87212478
64	MP0003453_abnormal_keratinocyte_physiol	0.82269784
65	MP0001663_abnormal_digestive_system	0.81584510
66	MP0009764_decreased_sensitivity_to	0.80977644
67	MP0005000_abnormal_immune_tolerance	0.80926519
68	MP0003879_abnormal_hair_cell	0.79783300
69	MP0009763_increased_sensitivity_to	0.78988681
70	MP0002277_abnormal_respiratory_mucosa	0.76908306
71	MP0002136_abnormal_kidney_physiology	0.75904950
72	MP0005464_abnormal_platelet_physiology	0.75679087
73	MP0000249_abnormal_blood_vessel	0.75335439
74	MP0000598_abnormal_liver_morphology	0.73484365
75	MP0010352_gastrointestinal_tract_polyps	0.73193432
76	MP0009642_abnormal_blood_homeostasis	0.71721410
77	MP0003638_abnormal_response/metabolism_	0.71639393
78	MP0002452_abnormal_antigen_presenting	0.71124325
79	MP0003705_abnormal_hypodermis_morpholog	0.70584113
80	MP0002796_impaired_skin_barrier	0.70461440
81	MP0002971_abnormal_brown_adipose	0.69411571
82	MP0009697_abnormal_copulation	0.68692845
83	MP0002723_abnormal_immune_serum	0.68601585
84	MP0005409_darkened_coat_color	0.67129241
85	MP0000465_gastrointestinal_hemorrhage	0.65233734
86	MP0002168_other_aberrant_phenotype	0.64329118
87	MP0003763_abnormal_thymus_physiology	0.61836161
88	MP0005381_digestive/alimentary_phenotyp	0.61068847
89	MP0005636_abnormal_mineral_homeostasis	0.60934514
90	MP0005164_abnormal_response_to	0.58650851
91	MP0003566_abnormal_cell_adhesion	0.58543905
92	MP0002098_abnormal_vibrissa_morphology	0.58228085
93	MP0002166_altered_tumor_susceptibility	0.57960231
94	MP0000477_abnormal_intestine_morphology	0.54944949
95	MP0005376_homeostasis/metabolism_phenot	0.54624141
96	MP0005670_abnormal_white_adipose	0.54175255
97	MP0008874_decreased_physiological_sensi	0.53366762
98	MP0001851_eye_inflammation	0.53209224
99	MP0000678_abnormal_parathyroid_gland	0.52667232
100	MP0002132_abnormal_respiratory_system	0.52044449

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of monocarboxylic acid metabolism (HP:0010996)	8.37386488
2	Systemic lupus erythematosus (HP:0002725)	7.85388909
3	Deep venous thrombosis (HP:0002625)	7.42488667
4	Complement deficiency (HP:0004431)	7.24748569
5	Abnormality of complement system (HP:0005339)	6.40677907
6	Hypobetalipoproteinemia (HP:0003563)	6.28579777
7	Glomerulonephritis (HP:0000099)	6.01832811
8	Abnormality of aromatic amino acid family metabolism (HP:0004338)	5.65943594
9	Prolonged partial thromboplastin time (HP:0003645)	5.62221626
10	Abnormality of glutamine family amino acid metabolism (HP:0010902)	5.41399945
11	Joint hemorrhage (HP:0005261)	5.28529816
12	Nephritis (HP:0000123)	4.58910618
13	Xanthomatosis (HP:0000991)	4.46127056
14	Malnutrition (HP:0004395)	4.34568174
15	Hyperlipoproteinemia (HP:0010980)	4.16303843
16	Hemorrhage of the eye (HP:0011885)	3.88457726
17	Abnormality of pyrimidine metabolism (HP:0004353)	3.77298295
18	Abnormality of proline metabolism (HP:0010907)	3.59598229
19	Hydroxyprolinuria (HP:0003080)	3.59598229
20	Conjugated hyperbilirubinemia (HP:0002908)	3.57740148
21	Intrahepatic cholestasis (HP:0001406)	3.51344268
22	Hypolipoproteinemia (HP:0010981)	3.46646611
23	Fat malabsorption (HP:0002630)	3.38765015
24	Purpura (HP:0000979)	3.13717451
25	Menorrhagia (HP:0000132)	2.96985606
26	Abnormality of the common coagulation pathway (HP:0010990)	2.86211752
27	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.80679297
28	Recurrent gram-negative bacterial infections (HP:0005420)	2.79791224
29	Steatorrhea (HP:0002570)	2.76895853
30	Gingival bleeding (HP:0000225)	2.70679218
31	Vascular calcification (HP:0004934)	2.58694358
32	Mitral stenosis (HP:0001718)	2.56659516
33	Hyperammonemia (HP:0001987)	2.45720395
34	Hypercholesterolemia (HP:0003124)	2.41689543
35	Pulmonary embolism (HP:0002204)	2.41147314
36	Rickets (HP:0002748)	2.38109779
37	Myocardial infarction (HP:0001658)	2.28140807
38	Cardiovascular calcification (HP:0011915)	2.27974508
39	Thrombophlebitis (HP:0004418)	2.26520234
40	Eczematoid dermatitis (HP:0000976)	2.23414555
41	Polygenic inheritance (HP:0010982)	2.22730597
42	Spontaneous abortion (HP:0005268)	2.20536742
43	Hypoalphalipoproteinemia (HP:0003233)	2.20240750
44	Cerebral palsy (HP:0100021)	2.19880043
45	Abnormality of nucleobase metabolism (HP:0010932)	2.19652161
46	Abnormality of the intrinsic pathway (HP:0010989)	2.09570367
47	Polycythemia (HP:0001901)	2.09546694
48	Abnormality of the nasal mucosa (HP:0000433)	2.07983948
49	Joint swelling (HP:0001386)	2.06117267
50	Hyperglycinuria (HP:0003108)	2.05408850
51	Ileus (HP:0002595)	1.99573539
52	Focal segmental glomerulosclerosis (HP:0000097)	1.97565011
53	Abnormality of the Achilles tendon (HP:0005109)	1.97238750
54	Gangrene (HP:0100758)	1.97182788
55	Abnormality of glycine metabolism (HP:0010895)	1.96348997
56	Abnormality of serine family amino acid metabolism (HP:0010894)	1.96348997
57	Abnormality of small intestinal villus morphology (HP:0011472)	1.95791936
58	Villous atrophy (HP:0011473)	1.95791936
59	Increased IgE level (HP:0003212)	1.91356868
60	Gastrointestinal stroma tumor (HP:0100723)	1.91252890
61	Colitis (HP:0002583)	1.90962040
62	Hypophosphatemia (HP:0002148)	1.89285423
63	Emphysema (HP:0002097)	1.88875499
64	Delayed CNS myelination (HP:0002188)	1.86237591
65	Epistaxis (HP:0000421)	1.86173087
66	Elevated alkaline phosphatase (HP:0003155)	1.84409440
67	Hepatocellular carcinoma (HP:0001402)	1.81628906
68	Periodontitis (HP:0000704)	1.79889822
69	Urinary glycosaminoglycan excretion (HP:0003541)	1.79794079
70	Mucopolysacchariduria (HP:0008155)	1.79794079
71	Amyloidosis (HP:0011034)	1.79359561
72	Chronic otitis media (HP:0000389)	1.78296496
73	Alkalosis (HP:0001948)	1.77897157
74	Vasculitis (HP:0002633)	1.76899360
75	Hypochromic anemia (HP:0001931)	1.75334264
76	Abnormality of vitamin metabolism (HP:0100508)	1.75212023
77	Abnormal enzyme/coenzyme activity (HP:0012379)	1.73541947
78	Skin rash (HP:0000988)	1.73467984
79	Increased serum ferritin (HP:0003281)	1.73051031
80	Bone pain (HP:0002653)	1.72469568
81	Abnormality of alkaline phosphatase activity (HP:0004379)	1.71363701
82	Gingivitis (HP:0000230)	1.71147273
83	Abnormal gallbladder physiology (HP:0012438)	1.70969495
84	Cholecystitis (HP:0001082)	1.70969495
85	Pancreatitis (HP:0001733)	1.70662838
86	Gout (HP:0001997)	1.70524035
87	Generalized aminoaciduria (HP:0002909)	1.69542648
88	Nasal polyposis (HP:0100582)	1.69484234
89	Epidermoid cyst (HP:0200040)	1.69279277
90	Orchitis (HP:0100796)	1.66436679
91	Recurrent bronchitis (HP:0002837)	1.65818916
92	Stroke (HP:0001297)	1.65750595
93	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.63631202
94	Abnormality of polysaccharide metabolism (HP:0011012)	1.63631202
95	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.63631202
96	Glomerulosclerosis (HP:0000096)	1.61564347
97	Abdominal distention (HP:0003270)	1.60262689
98	Acne (HP:0001061)	1.59862880
99	Pulmonary infiltrates (HP:0002113)	1.59732482
100	Late onset (HP:0003584)	1.56846005

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ERN1	5.52451476
2	FGFR4	4.99115910
3	RIPK1	4.46867782
4	MST1R	4.13165864
5	TYK2	3.55956986
6	SMG1	2.85461512
7	EPHA3	2.77614549
8	FGFR3	2.49792878
9	TRIB3	2.41988857
10	MAP4K1	2.15143737
11	TBK1	2.14662255
12	EPHA2	2.13765391
13	PRPF4B	2.04082874
14	JAK1	2.02555076
15	EPHB1	1.85544537
16	IRAK3	1.82647301
17	IKBKE	1.73522956
18	MAP3K14	1.72488032
19	CDC42BPA	1.58380761
20	JAK3	1.48971435
21	MET	1.41937852
22	PTK6	1.30505838
23	MAP3K3	1.27947869
24	SIK1	1.16229545
25	KIT	1.15450946
26	ZAP70	1.13890280
27	TGFBR2	1.13320540
28	EPHB2	1.11285513
29	MAP3K1	1.10761493
30	FER	1.05319380
31	PDK2	1.02521994
32	DDR2	0.99914958
33	ICK	0.99220608
34	PDGFRA	0.98883787
35	MAPK11	0.98105638
36	MATK	0.97749517
37	IRAK1	0.95287382
38	BLK	0.93095408
39	KDR	0.91928688
40	HIPK2	0.89910721
41	MAP3K11	0.89221619
42	PRKG2	0.87580639
43	NLK	0.84945346
44	CHUK	0.80876138
45	CSF1R	0.80831223
46	MAP3K10	0.80170045
47	IKBKB	0.79465049
48	JAK2	0.78331111
49	PIK3CA	0.77861258
50	PDPK1	0.74306895
51	PKN2	0.74103558
52	ACVR1B	0.72597621
53	TAOK1	0.72582180
54	MAP3K2	0.72450768
55	MAP3K13	0.72327599
56	ERBB2	0.67338671
57	MAPK7	0.67177306
58	RET	0.64072990
59	MAP3K12	0.63535113
60	MAPKAPK3	0.62440616
61	LRRK2	0.61279252
62	TIE1	0.59661778
63	GRK6	0.58540070
64	PRKAA2	0.51427653
65	PRKACG	0.50966214
66	IGF1R	0.46865782
67	LCK	0.46803005
68	TESK2	0.45821601
69	CSK	0.45570738
70	SRC	0.43801199
71	IRAK4	0.42124539
72	MAP3K7	0.41938106
73	PRKD2	0.41105007
74	MAP2K2	0.40931475
75	PDK1	0.40628178
76	RIPK4	0.40286090
77	PTK2	0.39917114
78	DYRK1B	0.39846415
79	CDK12	0.38567207
80	FES	0.37990612
81	CDK9	0.36830576
82	MYLK	0.36233511
83	LYN	0.35782303
84	MAPKAPK2	0.35491842
85	PAK4	0.32696813
86	FYN	0.32677295
87	TESK1	0.32139688
88	MTOR	0.31871358
89	MAP3K6	0.30647900
90	PRKCZ	0.29867010
91	DMPK	0.28786594
92	DAPK1	0.27379641
93	SIK2	0.26608581
94	MAPK4	0.25696878
95	MAPK3	0.25500951
96	NME1	0.24954105
97	NEK6	0.24743847
98	SYK	0.24195541
99	ABL2	0.23536876
100	SIK3	0.22752607

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Complement and coagulation cascades_Homo sapiens_hsa04610	3.82667241
2	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.81556508
3	Caffeine metabolism_Homo sapiens_hsa00232	3.60437842
4	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.23246139
5	Arginine biosynthesis_Homo sapiens_hsa00220	2.89079657
6	Retinol metabolism_Homo sapiens_hsa00830	2.84157850
7	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.76741309
8	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.72983829
9	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.64697385
10	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.63205313
11	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.57547471
12	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.54549882
13	Chemical carcinogenesis_Homo sapiens_hsa05204	2.46974801
14	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.39484454
15	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.30540056
16	Phenylalanine metabolism_Homo sapiens_hsa00360	2.14495335
17	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.05887372
18	Histidine metabolism_Homo sapiens_hsa00340	2.05207530
19	Fatty acid degradation_Homo sapiens_hsa00071	1.94996274
20	Fat digestion and absorption_Homo sapiens_hsa04975	1.92207689
21	Bile secretion_Homo sapiens_hsa04976	1.72932816
22	Tyrosine metabolism_Homo sapiens_hsa00350	1.64179871
23	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.61830057
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.60022490
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.54838824
26	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.54661497
27	PPAR signaling pathway_Homo sapiens_hsa03320	1.52602521
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.32211608
29	Butanoate metabolism_Homo sapiens_hsa00650	1.31891629
30	Arginine and proline metabolism_Homo sapiens_hsa00330	1.25187081
31	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.12519314
32	Asthma_Homo sapiens_hsa05310	1.12256237
33	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.07882604
34	Pertussis_Homo sapiens_hsa05133	1.07390352
35	Sulfur metabolism_Homo sapiens_hsa00920	1.04222379
36	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.02549711
37	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.01783502
38	Other glycan degradation_Homo sapiens_hsa00511	1.00131137
39	Allograft rejection_Homo sapiens_hsa05330	0.99032988
40	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.98373342
41	Prion diseases_Homo sapiens_hsa05020	0.94820155
42	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.92507343
43	Peroxisome_Homo sapiens_hsa04146	0.92239452
44	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.91444628
45	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.90252272
46	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.88258826
47	Renin-angiotensin system_Homo sapiens_hsa04614	0.86593607
48	ABC transporters_Homo sapiens_hsa02010	0.84384936
49	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.82173613
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.80779913
51	Graft-versus-host disease_Homo sapiens_hsa05332	0.80283434
52	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.79292248
53	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.78214075
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.76370125
55	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.74762374
56	beta-Alanine metabolism_Homo sapiens_hsa00410	0.73353845
57	Galactose metabolism_Homo sapiens_hsa00052	0.70920073
58	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.69210524
59	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.68672058
60	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.68068952
61	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.66202640
62	Carbon metabolism_Homo sapiens_hsa01200	0.63991420
63	Glycerolipid metabolism_Homo sapiens_hsa00561	0.62288209
64	Antigen processing and presentation_Homo sapiens_hsa04612	0.62222596
65	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.59648453
66	Type I diabetes mellitus_Homo sapiens_hsa04940	0.59296651
67	Leishmaniasis_Homo sapiens_hsa05140	0.58703070
68	Pyruvate metabolism_Homo sapiens_hsa00620	0.55423570
69	Fatty acid metabolism_Homo sapiens_hsa01212	0.51468066
70	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.50218141
71	Hepatitis C_Homo sapiens_hsa05160	0.47041360
72	Influenza A_Homo sapiens_hsa05164	0.44318270
73	Toxoplasmosis_Homo sapiens_hsa05145	0.39906015
74	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.38159466
75	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.37229562
76	Glutathione metabolism_Homo sapiens_hsa00480	0.34934327
77	African trypanosomiasis_Homo sapiens_hsa05143	0.33989609
78	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.32456625
79	Protein digestion and absorption_Homo sapiens_hsa04974	0.31795408
80	Viral myocarditis_Homo sapiens_hsa05416	0.31750778
81	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.29233961
82	Insulin resistance_Homo sapiens_hsa04931	0.29172458
83	Herpes simplex infection_Homo sapiens_hsa05168	0.27215902
84	Pentose phosphate pathway_Homo sapiens_hsa00030	0.26609324
85	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.24565369
86	Mineral absorption_Homo sapiens_hsa04978	0.24550334
87	Sulfur relay system_Homo sapiens_hsa04122	0.24172995
88	Lysine degradation_Homo sapiens_hsa00310	0.23588354
89	Primary immunodeficiency_Homo sapiens_hsa05340	0.22727798
90	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.19576068
91	TNF signaling pathway_Homo sapiens_hsa04668	0.19525296
92	Metabolic pathways_Homo sapiens_hsa01100	0.18547945
93	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.17420081
94	Tuberculosis_Homo sapiens_hsa05152	0.16790648
95	Amoebiasis_Homo sapiens_hsa05146	0.15755337
96	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.15036423
97	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.14422058
98	Ether lipid metabolism_Homo sapiens_hsa00565	0.13718323
99	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.13033776
100	Lysosome_Homo sapiens_hsa04142	0.09939762

OR2I1P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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