OR2L13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)5.24735644
2synaptic vesicle maturation (GO:0016188)5.08894639
3synaptic vesicle docking involved in exocytosis (GO:0016081)4.89076913
4thrombin receptor signaling pathway (GO:0070493)4.73308540
5dopamine transport (GO:0015872)4.69780235
6regulation of female receptivity (GO:0045924)4.63961042
7regulation of short-term neuronal synaptic plasticity (GO:0048172)4.56839538
8regulation of synaptic vesicle exocytosis (GO:2000300)4.47708939
9membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.44042178
10adenosine receptor signaling pathway (GO:0001973)4.41228773
11monoamine transport (GO:0015844)4.41098778
12glutamate secretion (GO:0014047)4.34161552
13synaptic vesicle exocytosis (GO:0016079)4.32587896
14neutrophil activation involved in immune response (GO:0002283)4.08725591
15negative regulation of heart rate (GO:0010459)4.05223698
16neuronal action potential propagation (GO:0019227)3.97294884
17female mating behavior (GO:0060180)3.96886713
18regulation of dopamine metabolic process (GO:0042053)3.93749019
19regulation of catecholamine metabolic process (GO:0042069)3.93749019
20regulation of long-term neuronal synaptic plasticity (GO:0048169)3.79924746
21regulation of synaptic vesicle transport (GO:1902803)3.79190942
22regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.61628477
23synaptic transmission, glutamatergic (GO:0035249)3.58629692
24regulation of platelet aggregation (GO:0090330)3.57314419
25positive regulation of mast cell activation (GO:0033005)3.56841257
26catecholamine transport (GO:0051937)3.50987899
27regulation of sensory perception of pain (GO:0051930)3.43797881
28regulation of sensory perception (GO:0051931)3.43797881
29dopamine biosynthetic process (GO:0042416)3.39182585
30regulation of neuronal synaptic plasticity (GO:0048168)3.37435317
31vesicle docking involved in exocytosis (GO:0006904)3.35385431
32ionotropic glutamate receptor signaling pathway (GO:0035235)3.34623132
33purinergic nucleotide receptor signaling pathway (GO:0035590)3.28307033
34regulation of norepinephrine secretion (GO:0014061)3.27957835
35negative regulation of heart contraction (GO:0045822)3.27453964
36neurotransmitter secretion (GO:0007269)3.26588720
37neuron-neuron synaptic transmission (GO:0007270)3.25498381
38regulation of penile erection (GO:0060405)3.24306835
39synaptic vesicle endocytosis (GO:0048488)3.21167013
40negative regulation of response to food (GO:0032096)3.18699034
41negative regulation of appetite (GO:0032099)3.18699034
42negative regulation of norepinephrine secretion (GO:0010700)3.18613939
43negative regulation of stress fiber assembly (GO:0051497)3.15439853
44positive regulation of neurotransmitter secretion (GO:0001956)3.12939484
45megakaryocyte development (GO:0035855)3.12194625
46activation of protein kinase A activity (GO:0034199)3.08213322
47positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.07930130
48relaxation of smooth muscle (GO:0044557)3.07295227
49sleep (GO:0030431)3.06807298
50G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.06327851
51regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.05401612
52long-chain fatty acid biosynthetic process (GO:0042759)3.04974913
53neurotransmitter transport (GO:0006836)3.04797973
54negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04156989
55vesicle docking (GO:0048278)3.03965289
56neurotransmitter uptake (GO:0001504)3.03178825
57cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.95779499
58purinergic receptor signaling pathway (GO:0035587)2.95442335
59blood coagulation, intrinsic pathway (GO:0007597)2.92715628
60regulation of platelet activation (GO:0010543)2.92606399
61regulation of voltage-gated calcium channel activity (GO:1901385)2.91807698
62regulation of inositol phosphate biosynthetic process (GO:0010919)2.91212793
63negative regulation of actin filament bundle assembly (GO:0032232)2.90853882
64positive regulation of mast cell degranulation (GO:0043306)2.89650309
65positive regulation of mast cell activation involved in immune response (GO:0033008)2.89650309
66gamma-aminobutyric acid signaling pathway (GO:0007214)2.86782302
67glutamate receptor signaling pathway (GO:0007215)2.86197148
68regulation of neurotransmitter levels (GO:0001505)2.83413373
69cerebellar granule cell differentiation (GO:0021707)2.83303098
70positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.82045765
71positive regulation of neurotransmitter transport (GO:0051590)2.81844253
72L-amino acid import (GO:0043092)2.80800256
73regulation of cAMP-dependent protein kinase activity (GO:2000479)2.80025750
74endothelium development (GO:0003158)2.78434374
75sodium ion export (GO:0071436)2.78232967
76platelet aggregation (GO:0070527)2.77579387
77membrane depolarization during action potential (GO:0086010)2.76765377
78regulation of exocytosis (GO:0017157)2.74962350
79gamma-aminobutyric acid transport (GO:0015812)2.74778268
80negative regulation of calcium ion transmembrane transport (GO:1903170)2.72648275
81negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.72648275
82exploration behavior (GO:0035640)2.72437357
83negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.72039765
84cyclooxygenase pathway (GO:0019371)2.70552384
85negative regulation of neurotransmitter transport (GO:0051589)2.70065713
86negative regulation of cation channel activity (GO:2001258)2.69673133
87regulation of glutamate secretion (GO:0014048)2.69202752
88low-density lipoprotein particle remodeling (GO:0034374)2.68510329
89response to cocaine (GO:0042220)2.68027873
90response to amphetamine (GO:0001975)2.66816423
91G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.65272997
92positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.65194048
93cellular potassium ion homeostasis (GO:0030007)2.60769989
94regulation of excitatory postsynaptic membrane potential (GO:0060079)2.60438485
95synaptic transmission, dopaminergic (GO:0001963)2.59045781
96long term synaptic depression (GO:0060292)2.58480504
97regulation of neurotransmitter secretion (GO:0046928)2.58433029
98response to gravity (GO:0009629)2.57349078
99neuronal action potential (GO:0019228)2.56710191
100triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.55306710

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.91526467
2SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.67529611
3LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.37793345
4GBX2_23144817_ChIP-Seq_PC3_Human3.19155387
5SCL_19346495_ChIP-Seq_HPC-7_Human3.02542365
6DROSHA_22980978_ChIP-Seq_HELA_Human2.57937816
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.41112989
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31698816
9GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.31110730
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.25244743
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.16636622
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14871386
13REST_18959480_ChIP-ChIP_MESCs_Mouse2.13950527
14REST_21632747_ChIP-Seq_MESCs_Mouse2.13431539
15GATA1_19941826_ChIP-Seq_K562_Human2.07736756
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.01320875
17IKZF1_21737484_ChIP-ChIP_HCT116_Human1.92506552
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.89882417
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89565121
20GATA1_22025678_ChIP-Seq_K562_Human1.88740387
21GATA1_19941827_ChIP-Seq_MEL_Mouse1.86781502
22RARB_27405468_Chip-Seq_BRAIN_Mouse1.86030265
23MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84199288
24LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.84070327
25TAF15_26573619_Chip-Seq_HEK293_Human1.82817067
26HTT_18923047_ChIP-ChIP_STHdh_Human1.77206735
27IGF1R_20145208_ChIP-Seq_DFB_Human1.71332597
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71125404
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.69041373
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.68396207
31GATA2_21666600_ChIP-Seq_HMVEC_Human1.57636551
32GATA2_19941826_ChIP-Seq_K562_Human1.52706548
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.50440001
34GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.47221516
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.46816685
36TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44297374
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42417224
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41928711
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40797536
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.39783369
41* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37627232
42VDR_22108803_ChIP-Seq_LS180_Human1.37102938
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.35182186
44SPI1_23127762_ChIP-Seq_K562_Human1.32634364
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31524502
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29048254
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28550438
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25645495
49SMAD4_21799915_ChIP-Seq_A2780_Human1.24189166
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16904922
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16322073
52RNF2_27304074_Chip-Seq_NSC_Mouse1.15710407
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15165902
54TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11238484
55AR_21572438_ChIP-Seq_LNCaP_Human1.06843858
56KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.06612312
57AR_25329375_ChIP-Seq_VCAP_Human1.03833780
58P300_19829295_ChIP-Seq_ESCs_Human1.03696461
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03408315
60GATA1_19941827_ChIP-Seq_MEL86_Mouse1.02307733
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01786487
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.00094994
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.00094994
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98885407
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98847867
66ELK4_26923725_Chip-Seq_MESODERM_Mouse0.97064521
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96712914
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94632109
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93725844
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93006390
71FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92277686
72STAT3_23295773_ChIP-Seq_U87_Human0.91054067
73RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90977919
74OCT1_27270436_Chip-Seq_PROSTATE_Human0.89981253
75RNF2_27304074_Chip-Seq_ESCs_Mouse0.87813772
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87729783
77* TCF4_23295773_ChIP-Seq_U87_Human0.87089221
78EED_16625203_ChIP-ChIP_MESCs_Mouse0.86566098
79* SOX2_21211035_ChIP-Seq_LN229_Gbm0.85803498
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84193840
81SPI1_20517297_ChIP-Seq_HL60_Human0.83948542
82FLI1_27457419_Chip-Seq_LIVER_Mouse0.83370436
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82689399
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82426427
85E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.81870909
86DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81748345
87MYB_21317192_ChIP-Seq_ERMYB_Mouse0.81267716
88PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80944757
89SOX2_19829295_ChIP-Seq_ESCs_Human0.80046578
90NANOG_19829295_ChIP-Seq_ESCs_Human0.80046578
91PRDM14_20953172_ChIP-Seq_ESCs_Human0.79269305
92P53_22387025_ChIP-Seq_ESCs_Mouse0.79161011
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.78867503
94P53_22127205_ChIP-Seq_FIBROBLAST_Human0.78318971
95LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.76078356
96FLI1_21867929_ChIP-Seq_TH2_Mouse0.75801116
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.75673117
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.75646822
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.75279682
100CTCF_20526341_ChIP-Seq_ESCs_Human0.75155946

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.12555889
2MP0005464_abnormal_platelet_physiology4.98184253
3MP0003880_abnormal_central_pattern3.43771864
4MP0001968_abnormal_touch/_nociception3.33814490
5MP0003635_abnormal_synaptic_transmissio3.07091635
6MP0002736_abnormal_nociception_after3.04508826
7MP0008004_abnormal_stomach_pH2.81013019
8MP0009046_muscle_twitch2.77464608
9MP0005646_abnormal_pituitary_gland2.76652527
10MP0002064_seizures2.65723990
11MP0002735_abnormal_chemical_nociception2.65171121
12MP0009745_abnormal_behavioral_response2.57682695
13MP0002733_abnormal_thermal_nociception2.54127196
14MP0002272_abnormal_nervous_system2.39532846
15MP0002063_abnormal_learning/memory/cond2.36133660
16MP0005423_abnormal_somatic_nervous2.33311602
17MP0006276_abnormal_autonomic_nervous2.26219340
18MP0004270_analgesia2.16181128
19MP0001486_abnormal_startle_reflex2.15438415
20MP0001970_abnormal_pain_threshold2.12702079
21MP0000465_gastrointestinal_hemorrhage2.04068472
22MP0002572_abnormal_emotion/affect_behav2.02253852
23MP0005167_abnormal_blood-brain_barrier1.98265916
24MP0003879_abnormal_hair_cell1.97586029
25MP0001905_abnormal_dopamine_level1.95962524
26MP0008872_abnormal_physiological_respon1.94436127
27MP0005645_abnormal_hypothalamus_physiol1.84314190
28MP0002734_abnormal_mechanical_nocicepti1.68263211
29MP0009780_abnormal_chondrocyte_physiolo1.67362946
30MP0000230_abnormal_systemic_arterial1.67045134
31MP0001501_abnormal_sleep_pattern1.64814395
32MP0008569_lethality_at_weaning1.63890452
33MP0003183_abnormal_peptide_metabolism1.63567493
34MP0003724_increased_susceptibility_to1.56432950
35MP0001502_abnormal_circadian_rhythm1.49413460
36MP0001440_abnormal_grooming_behavior1.47063561
37MP0004215_abnormal_myocardial_fiber1.39640659
38MP0001986_abnormal_taste_sensitivity1.39340024
39MP0004147_increased_porphyrin_level1.38770429
40MP0003122_maternal_imprinting1.38725540
41MP0008874_decreased_physiological_sensi1.34598076
42MP0003329_amyloid_beta_deposits1.31856015
43MP0001984_abnormal_olfaction1.30507493
44MP0003638_abnormal_response/metabolism_1.26110694
45MP0002067_abnormal_sensory_capabilities1.25771166
46MP0003633_abnormal_nervous_system1.23913415
47MP0005410_abnormal_fertilization1.23325004
48MP0004142_abnormal_muscle_tone1.21285652
49MP0002822_catalepsy1.16303071
50MP0002557_abnormal_social/conspecific_i1.15626493
51MP0003787_abnormal_imprinting1.15341595
52MP0003631_nervous_system_phenotype1.10914912
53MP0004811_abnormal_neuron_physiology1.08732456
54MP0004885_abnormal_endolymph1.04347552
55MP0008775_abnormal_heart_ventricle1.03953535
56MP0006036_abnormal_mitochondrial_physio1.03551308
57MP0001188_hyperpigmentation1.02381873
58MP0004130_abnormal_muscle_cell1.01939726
59MP0004510_myositis0.99488665
60MP0002876_abnormal_thyroid_physiology0.97262439
61MP0004484_altered_response_of0.96965054
62MP0001835_abnormal_antigen_presentation0.96539991
63MP0005448_abnormal_energy_balance0.92922107
64MP0002066_abnormal_motor_capabilities/c0.92215225
65MP0001664_abnormal_digestion0.92090372
66MP0005535_abnormal_body_temperature0.90752958
67MP0001545_abnormal_hematopoietic_system0.90248170
68MP0005397_hematopoietic_system_phenotyp0.90248170
69MP0005551_abnormal_eye_electrophysiolog0.89366788
70MP0003690_abnormal_glial_cell0.88589575
71MP0002229_neurodegeneration0.88248774
72MP0003656_abnormal_erythrocyte_physiolo0.87715047
73MP0004924_abnormal_behavior0.85817989
74MP0005386_behavior/neurological_phenoty0.85817989
75MP0010386_abnormal_urinary_bladder0.84270921
76MP0003172_abnormal_lysosome_physiology0.83547511
77MP0006035_abnormal_mitochondrial_morpho0.83521083
78MP0004043_abnormal_pH_regulation0.81320699
79MP0004084_abnormal_cardiac_muscle0.80782500
80MP0000343_altered_response_to0.79151987
81MP0000604_amyloidosis0.77919512
82MP0000920_abnormal_myelination0.77865020
83MP0003303_peritoneal_inflammation0.76395088
84MP0008877_abnormal_DNA_methylation0.75915850
85MP0005165_increased_susceptibility_to0.75446712
86MP0000015_abnormal_ear_pigmentation0.75341268
87MP0009278_abnormal_bone_marrow0.75173933
88MP0002882_abnormal_neuron_morphology0.74891638
89MP0003075_altered_response_to0.74424387
90MP0004085_abnormal_heartbeat0.73198319
91MP0001765_abnormal_ion_homeostasis0.72137536
92MP0002148_abnormal_hypersensitivity_rea0.71150131
93MP0005058_abnormal_lysosome_morphology0.70469262
94MP0003632_abnormal_nervous_system0.67405992
95MP0001963_abnormal_hearing_physiology0.66353742
96MP0002069_abnormal_eating/drinking_beha0.64020745
97MP0005000_abnormal_immune_tolerance0.62519801
98MP0001756_abnormal_urination0.59270345
99MP0000681_abnormal_thyroid_gland0.58079725
100MP0005084_abnormal_gallbladder_morpholo0.58049188

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)7.75222373
2Menorrhagia (HP:0000132)6.61299172
3Increased mean platelet volume (HP:0011877)6.14994363
4Petechiae (HP:0000967)5.86055137
5Abnormal platelet volume (HP:0011876)5.77732182
6Purpura (HP:0000979)5.28630768
7Focal motor seizures (HP:0011153)5.24337930
8Epistaxis (HP:0000421)5.22855283
9Myokymia (HP:0002411)4.86844041
10Limb dystonia (HP:0002451)4.59649857
11Gingival bleeding (HP:0000225)4.41519375
12Febrile seizures (HP:0002373)4.27362241
13Diplopia (HP:0000651)3.96913044
14Abnormality of binocular vision (HP:0011514)3.96913044
15Focal seizures (HP:0007359)3.65386862
16Polyphagia (HP:0002591)3.51524360
17Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.50630897
18Degeneration of the lateral corticospinal tracts (HP:0002314)3.50630897
19Hyperlipoproteinemia (HP:0010980)3.50398955
20Abnormal eating behavior (HP:0100738)3.42351203
21Atonic seizures (HP:0010819)3.38753396
22Epileptic encephalopathy (HP:0200134)3.34820632
23Visual hallucinations (HP:0002367)3.29333438
24Abnormality of the heme biosynthetic pathway (HP:0010472)3.26482121
25Delusions (HP:0000746)3.22884206
26Supranuclear gaze palsy (HP:0000605)3.21886499
27Abnormality of the corticospinal tract (HP:0002492)3.07159017
28Impaired vibration sensation in the lower limbs (HP:0002166)3.02319071
29Spastic gait (HP:0002064)2.99509926
30Impaired platelet aggregation (HP:0003540)2.99097488
31Abnormal platelet function (HP:0011869)2.99097488
32Ankle clonus (HP:0011448)2.91711096
33Decreased central vision (HP:0007663)2.80518375
34Urinary bladder sphincter dysfunction (HP:0002839)2.80430688
35Generalized tonic-clonic seizures (HP:0002069)2.72296010
36Poor eye contact (HP:0000817)2.70748374
37Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.68553668
38Poikilocytosis (HP:0004447)2.58045735
39Action tremor (HP:0002345)2.54398074
40Acanthocytosis (HP:0001927)2.49906258
41Mutism (HP:0002300)2.47688307
42Urinary urgency (HP:0000012)2.47435027
43Morphological abnormality of the pyramidal tract (HP:0002062)2.46759003
44Postural instability (HP:0002172)2.44585969
45Thyroid-stimulating hormone excess (HP:0002925)2.44510795
46Dialeptic seizures (HP:0011146)2.44189501
47Spontaneous abortion (HP:0005268)2.43051417
48Failure to thrive in infancy (HP:0001531)2.39855475
49Progressive cerebellar ataxia (HP:0002073)2.37488733
50Papilledema (HP:0001085)2.28910717
51Cerebral hypomyelination (HP:0006808)2.28809330
52Conjunctival telangiectasia (HP:0000524)2.27205872
53Abnormal pupillary function (HP:0007686)2.27072643
54Ventricular fibrillation (HP:0001663)2.25608302
55Torticollis (HP:0000473)2.25589882
56Hemiplegia (HP:0002301)2.25576643
57Absence seizures (HP:0002121)2.22508037
58Lower limb muscle weakness (HP:0007340)2.22231998
59Spontaneous hematomas (HP:0007420)2.18297698
60Paralysis (HP:0003470)2.18146031
61Abnormality of the vasculature of the conjunctiva (HP:0008054)2.15671706
62Dyschromatopsia (HP:0007641)2.14337428
63Focal dystonia (HP:0004373)2.13180702
64Impaired vibratory sensation (HP:0002495)2.12712510
65Craniofacial dystonia (HP:0012179)2.11669987
66Truncal ataxia (HP:0002078)2.07971262
67Bradykinesia (HP:0002067)2.06748232
68Hyperthyroidism (HP:0000836)2.03189940
69Abnormality of iron homeostasis (HP:0011031)2.02701740
70Agitation (HP:0000713)2.01723680
71Bruising susceptibility (HP:0000978)2.01418127
72Memory impairment (HP:0002354)2.00265386
73Cerebral inclusion bodies (HP:0100314)2.00048312
74Impaired social interactions (HP:0000735)1.99826388
75Abnormal social behavior (HP:0012433)1.99826388
76Termporal pattern (HP:0011008)1.96842003
77Insidious onset (HP:0003587)1.96842003
78Split foot (HP:0001839)1.94003999
79Scanning speech (HP:0002168)1.92460913
80Hemiparesis (HP:0001269)1.88394172
81Rigidity (HP:0002063)1.88045587
82Neurofibrillary tangles (HP:0002185)1.85239930
83Autoimmune hemolytic anemia (HP:0001890)1.84191384
84Hypokinesia (HP:0002375)1.83868734
85Autoamputation (HP:0001218)1.83047417
86Clonus (HP:0002169)1.79337350
87Acute lymphatic leukemia (HP:0006721)1.78904185
88Status epilepticus (HP:0002133)1.74113401
893-Methylglutaconic aciduria (HP:0003535)1.73387448
90Abnormality of transition element cation homeostasis (HP:0011030)1.73376668
91Dyskinesia (HP:0100660)1.73330227
92Joint swelling (HP:0001386)1.71177344
93Stomatitis (HP:0010280)1.69259367
94Anxiety (HP:0000739)1.68254128
95Lower limb amyotrophy (HP:0007210)1.65657395
96Tetraplegia (HP:0002445)1.64029926
97Diminished movement (HP:0002374)1.60318808
98Episodic fever (HP:0001954)1.60294156
99Akinesia (HP:0002304)1.60178348
100Abnormal EKG (HP:0003115)1.58398627

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DAPK23.88094772
2MST43.45817965
3RIPK43.36695159
4GRK73.14500926
5FES2.85954062
6EPHA42.85455383
7GRK52.67884317
8TAOK32.62725753
9NTRK32.10078342
10CAMKK22.05827805
11SIK22.02890903
12BMX1.99582364
13DAPK11.91884866
14TEC1.90071587
15CAMKK11.73392857
16MAP2K71.69177036
17BMPR21.67409354
18PAK61.63963464
19PTK2B1.63096683
20SYK1.62237998
21MINK11.59846438
22TNK21.55028172
23NTRK21.54295621
24MYLK1.53588697
25PLK21.49260633
26MARK11.47549035
27MAP3K121.46270769
28MAPK131.43359623
29BTK1.43249938
30PKN11.36194284
31CDK191.31009978
32DAPK31.28806568
33CAMK2B1.27653986
34CSF1R1.20745276
35ADRBK11.13289398
36CAMK11.09936227
37TLK11.08781665
38CAMK2A1.08320301
39HCK1.04257539
40PNCK1.04143271
41MAPKAPK51.02484093
42PHKG11.02356489
43PHKG21.02356489
44PRKD30.97445719
45FGR0.97439949
46EPHA30.95052593
47CDK50.91229387
48RET0.88748442
49PINK10.87883845
50CAMK2G0.86125636
51MARK20.85752441
52PAK30.85378294
53MAP3K40.84403233
54CCNB10.82319521
55UHMK10.82303863
56KIT0.81551625
57CAMK2D0.78619955
58CSNK1G20.77741721
59FER0.77717719
60PRKCG0.76375078
61ADRBK20.75534560
62GRK60.75514776
63MAPK120.73193018
64LYN0.72774488
65CSNK1G30.70922789
66MAP3K10.70013989
67ILK0.69872983
68MAP3K50.69720026
69CDK140.69348311
70MAP3K60.67846592
71ITK0.67565336
72PBK0.65138423
73MAP2K40.63178111
74IRAK10.61416427
75CDK150.58706201
76TXK0.57606248
77PDK10.57445946
78CDK180.57402657
79BRSK20.57282421
80DYRK1A0.57054087
81ERBB20.57019640
82NME10.55641676
83PIK3CG0.55093809
84MAPKAPK30.54911961
85PRKCA0.54054391
86ZAP700.52441195
87PAK10.50461540
88CDK11A0.50326112
89PRKACG0.50143812
90ARAF0.49470875
91JAK20.49045393
92FYN0.48673380
93OXSR10.47822811
94PRKD10.45200710
95SIK30.45045561
96TNIK0.41662611
97LMTK20.40176624
98MATK0.38512091
99PRKACA0.37961292
100MAPK100.34381368

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.44643536
2Synaptic vesicle cycle_Homo sapiens_hsa047213.43486869
3Platelet activation_Homo sapiens_hsa046113.06453712
4SNARE interactions in vesicular transport_Homo sapiens_hsa041302.69051860
5Circadian entrainment_Homo sapiens_hsa047132.66629221
6Amphetamine addiction_Homo sapiens_hsa050312.61374884
7GABAergic synapse_Homo sapiens_hsa047272.53120365
8Morphine addiction_Homo sapiens_hsa050322.53028354
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.43792243
10Collecting duct acid secretion_Homo sapiens_hsa049662.33264661
11Glutamatergic synapse_Homo sapiens_hsa047242.29737502
12Cocaine addiction_Homo sapiens_hsa050302.22706346
13Long-term potentiation_Homo sapiens_hsa047202.17997861
14Serotonergic synapse_Homo sapiens_hsa047261.94464655
15Dopaminergic synapse_Homo sapiens_hsa047281.91970180
16* Olfactory transduction_Homo sapiens_hsa047401.85781613
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.80662678
18Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.75431849
19Gastric acid secretion_Homo sapiens_hsa049711.73321225
20Salivary secretion_Homo sapiens_hsa049701.68130018
21Insulin secretion_Homo sapiens_hsa049111.64995464
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60389197
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.59825713
24Taste transduction_Homo sapiens_hsa047421.55733275
25Calcium signaling pathway_Homo sapiens_hsa040201.53502503
26Gap junction_Homo sapiens_hsa045401.51585601
27Long-term depression_Homo sapiens_hsa047301.50451136
28Renin secretion_Homo sapiens_hsa049241.49659496
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.45593033
30Cholinergic synapse_Homo sapiens_hsa047251.44411948
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33669138
32Oxytocin signaling pathway_Homo sapiens_hsa049211.30467852
33Vascular smooth muscle contraction_Homo sapiens_hsa042701.29939670
34Pancreatic secretion_Homo sapiens_hsa049721.28537618
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26303907
36Asthma_Homo sapiens_hsa053101.22668434
37Arachidonic acid metabolism_Homo sapiens_hsa005901.12223563
38Alcoholism_Homo sapiens_hsa050341.11579643
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06456850
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.05656288
41Hematopoietic cell lineage_Homo sapiens_hsa046401.02750007
42Phospholipase D signaling pathway_Homo sapiens_hsa040721.01235235
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97428850
44cAMP signaling pathway_Homo sapiens_hsa040240.97210263
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90568738
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89639859
47Nitrogen metabolism_Homo sapiens_hsa009100.85718565
48Endocytosis_Homo sapiens_hsa041440.85560930
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85407577
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82833286
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81866469
52ECM-receptor interaction_Homo sapiens_hsa045120.78470153
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76245503
54Regulation of autophagy_Homo sapiens_hsa041400.73195117
55GnRH signaling pathway_Homo sapiens_hsa049120.72397080
56Chemokine signaling pathway_Homo sapiens_hsa040620.69222015
57Rheumatoid arthritis_Homo sapiens_hsa053230.68411841
58Oocyte meiosis_Homo sapiens_hsa041140.65545091
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64771156
60Ras signaling pathway_Homo sapiens_hsa040140.64308424
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62985130
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61475690
63Choline metabolism in cancer_Homo sapiens_hsa052310.60954184
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.60511310
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60251302
66Phototransduction_Homo sapiens_hsa047440.58522973
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56705380
68Phagosome_Homo sapiens_hsa041450.53322454
69Circadian rhythm_Homo sapiens_hsa047100.53184567
70Type I diabetes mellitus_Homo sapiens_hsa049400.52993673
71Ovarian steroidogenesis_Homo sapiens_hsa049130.51976264
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51847454
73Glycerolipid metabolism_Homo sapiens_hsa005610.51662203
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.49953633
75Vibrio cholerae infection_Homo sapiens_hsa051100.48912183
76Graft-versus-host disease_Homo sapiens_hsa053320.48764593
77Parkinsons disease_Homo sapiens_hsa050120.47931771
78Rap1 signaling pathway_Homo sapiens_hsa040150.47641200
79Allograft rejection_Homo sapiens_hsa053300.46338466
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43208624
81Systemic lupus erythematosus_Homo sapiens_hsa053220.43124319
82Autoimmune thyroid disease_Homo sapiens_hsa053200.42888736
83Shigellosis_Homo sapiens_hsa051310.42571898
84ABC transporters_Homo sapiens_hsa020100.37993254
85Bile secretion_Homo sapiens_hsa049760.37890148
86Estrogen signaling pathway_Homo sapiens_hsa049150.37863096
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37565269
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34748486
89Glioma_Homo sapiens_hsa052140.34527063
90MAPK signaling pathway_Homo sapiens_hsa040100.34381353
91Sphingolipid metabolism_Homo sapiens_hsa006000.31982492
92Linoleic acid metabolism_Homo sapiens_hsa005910.31909314
93Dilated cardiomyopathy_Homo sapiens_hsa054140.31080865
94Peroxisome_Homo sapiens_hsa041460.30217537
95Salmonella infection_Homo sapiens_hsa051320.29793321
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.29756642
97Inositol phosphate metabolism_Homo sapiens_hsa005620.29363681
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28667431
99B cell receptor signaling pathway_Homo sapiens_hsa046620.28553814
100beta-Alanine metabolism_Homo sapiens_hsa004100.26293390

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