ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	6.83333841
2	purine nucleotide salvage (GO:0032261)	6.26979872
3	viral mRNA export from host cell nucleus (GO:0046784)	5.89370014
4	regulation of mitochondrial translation (GO:0070129)	5.73050925
5	autophagic vacuole fusion (GO:0000046)	5.61915650
6	pyrimidine nucleotide catabolic process (GO:0006244)	5.60413254
7	deoxyribonucleotide catabolic process (GO:0009264)	5.56379189
8	negative regulation of erythrocyte differentiation (GO:0045647)	5.45492929
9	deoxyribose phosphate catabolic process (GO:0046386)	5.22716987
10	nucleotide salvage (GO:0043173)	5.19334954
11	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	5.06378304
12	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.98595705
13	purine deoxyribonucleotide catabolic process (GO:0009155)	4.97990716
14	erythrocyte maturation (GO:0043249)	4.82600247
15	hemoglobin metabolic process (GO:0020027)	4.75122141
16	protoporphyrinogen IX metabolic process (GO:0046501)	4.72631886
17	purine-containing compound salvage (GO:0043101)	4.70271350
18	definitive hemopoiesis (GO:0060216)	4.65619229
19	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	4.63606307
20	negative regulation of telomere maintenance (GO:0032205)	4.52356333
21	positive regulation of megakaryocyte differentiation (GO:0045654)	4.51447126
22	porphyrin-containing compound biosynthetic process (GO:0006779)	4.39937822
23	organelle membrane fusion (GO:0090174)	4.32842254
24	mitochondrial calcium ion transport (GO:0006851)	4.28336813
25	negative regulation of B cell apoptotic process (GO:0002903)	4.27632777
26	UV protection (GO:0009650)	4.27136312
27	heme biosynthetic process (GO:0006783)	4.21179014
28	positive regulation of B cell differentiation (GO:0045579)	4.20195060
29	sexual reproduction (GO:0019953)	4.18735070
30	regulation of hydrogen peroxide metabolic process (GO:0010310)	4.14784903
31	valine metabolic process (GO:0006573)	4.04442109
32	oxygen transport (GO:0015671)	4.00410688
33	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.99627811
34	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.99627811
35	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.98214363
36	mucosal-associated lymphoid tissue development (GO:0048537)	3.98081041
37	Peyers patch development (GO:0048541)	3.98081041
38	protoporphyrinogen IX biosynthetic process (GO:0006782)	3.96224236
39	seminiferous tubule development (GO:0072520)	3.90325428
40	2-deoxyribonucleotide metabolic process (GO:0009394)	3.87081025
41	positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)	3.86489423
42	tetrapyrrole biosynthetic process (GO:0033014)	3.81196152
43	purine deoxyribonucleotide metabolic process (GO:0009151)	3.78035188
44	regulation of penile erection (GO:0060405)	3.76825639
45	regulation of erythrocyte differentiation (GO:0045646)	3.63408203
46	deoxyribose phosphate metabolic process (GO:0019692)	3.61560816
47	protein complex biogenesis (GO:0070271)	3.61287853
48	protein maturation by protein folding (GO:0022417)	3.59493014
49	porphyrin-containing compound metabolic process (GO:0006778)	3.58782533
50	regulation of monocyte differentiation (GO:0045655)	3.53956553
51	regulation of telomere maintenance (GO:0032204)	3.53418218
52	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	3.47814246
53	sequestering of actin monomers (GO:0042989)	3.45967434
54	heme metabolic process (GO:0042168)	3.43454939
55	mast cell degranulation (GO:0043303)	3.43342633
56	mast cell activation involved in immune response (GO:0002279)	3.43342633
57	erythrocyte development (GO:0048821)	3.42175642
58	positive regulation of granulocyte differentiation (GO:0030854)	3.40465510
59	mitochondrial respiratory chain complex assembly (GO:0033108)	3.40011006
60	NADH dehydrogenase complex assembly (GO:0010257)	3.38573417
61	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.38573417
62	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.38573417
63	estrogen biosynthetic process (GO:0006703)	3.36782554
64	gas transport (GO:0015669)	3.35559116
65	ribosomal small subunit assembly (GO:0000028)	3.29479208
66	positive regulation of prostaglandin secretion (GO:0032308)	3.29435153
67	purine nucleobase metabolic process (GO:0006144)	3.28849057
68	modulation by virus of host process (GO:0019054)	3.22595656
69	pseudouridine synthesis (GO:0001522)	3.16508625
70	positive regulation of protein homodimerization activity (GO:0090073)	3.10352775
71	negative regulation of mRNA processing (GO:0050686)	3.03596920
72	deoxyribonucleotide metabolic process (GO:0009262)	3.02077774
73	granulocyte differentiation (GO:0030851)	2.99800372
74	NIK/NF-kappaB signaling (GO:0038061)	2.97888880
75	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.94930381
76	lipopolysaccharide biosynthetic process (GO:0009103)	2.93816737
77	response to vitamin E (GO:0033197)	2.93116756
78	branched-chain amino acid metabolic process (GO:0009081)	2.93041864
79	regulation of B cell apoptotic process (GO:0002902)	2.91302404
80	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.87220474
81	DNA deamination (GO:0045006)	2.86802491
82	pyrimidine nucleoside catabolic process (GO:0046135)	2.85153899
83	response to misfolded protein (GO:0051788)	2.85107893
84	regulation of dopamine metabolic process (GO:0042053)	2.85060035
85	regulation of catecholamine metabolic process (GO:0042069)	2.85060035
86	regulation of megakaryocyte differentiation (GO:0045652)	2.82774329
87	hydrogen peroxide catabolic process (GO:0042744)	2.82043884
88	mitochondrial calcium ion homeostasis (GO:0051560)	2.81700443
89	purine nucleobase biosynthetic process (GO:0009113)	2.77786164
90	establishment of integrated proviral latency (GO:0075713)	2.75730827
91	grooming behavior (GO:0007625)	2.74713322
92	DNA topological change (GO:0006265)	2.73224958
93	regulation of hypersensitivity (GO:0002883)	2.72814803
94	mannosylation (GO:0097502)	2.72689574
95	negative regulation of macrophage differentiation (GO:0045650)	2.69283324
96	positive regulation of natural killer cell differentiation (GO:0032825)	2.68709122
97	lipopolysaccharide metabolic process (GO:0008653)	2.67855694
98	iron-sulfur cluster assembly (GO:0016226)	2.67787672
99	metallo-sulfur cluster assembly (GO:0031163)	2.67787672
100	negative regulation of RNA splicing (GO:0033119)	2.67484771

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.96192250
2	SCL_19346495_ChIP-Seq_HPC-7_Human	4.85141657
3	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.42465046
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.14958115
5	GATA1_19941826_ChIP-Seq_K562_Human	3.04585168
6	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.02817052
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.97527143
8	VDR_21846776_ChIP-Seq_THP-1_Human	2.95529097
9	GATA1_22025678_ChIP-Seq_K562_Human	2.68256212
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.58648583
11	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	2.55501659
12	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.48501876
13	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.34947117
14	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	2.32909200
15	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.31070531
16	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	2.24130143
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.17821171
18	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	2.16482852
19	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.09740969
20	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.07919617
21	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	2.05627384
22	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.03842346
23	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.95454704
24	CIITA_25753668_ChIP-Seq_RAJI_Human	1.90566612
25	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.89360227
26	VDR_24763502_ChIP-Seq_THP-1_Human	1.89013977
27	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.85128312
28	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.84255150
29	BCL6_27268052_Chip-Seq_Bcells_Human	1.80707959
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.79680700
31	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.76710029
32	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.73492539
33	UTX_26944678_Chip-Seq_JUKART_Human	1.71836066
34	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.70859631
35	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.67983524
36	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.67503210
37	MYC_22102868_ChIP-Seq_BL_Human	1.65874913
38	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.65367517
39	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.63546337
40	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.61035066
41	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.53188806
42	VDR_23849224_ChIP-Seq_CD4+_Human	1.49395491
43	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.48761627
44	P300_27268052_Chip-Seq_Bcells_Human	1.46935394
45	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.46294028
46	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.46233183
47	FOXP3_21729870_ChIP-Seq_TREG_Human	1.46168056
48	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.44889135
49	MYB_26560356_Chip-Seq_TH2_Human	1.43906092
50	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.43513772
51	BCOR_27268052_Chip-Seq_Bcells_Human	1.42165074
52	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.41607823
53	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.39415177
54	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.38986497
55	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.38712902
56	SPI1_23547873_ChIP-Seq_NB4_Human	1.38256876
57	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.37369267
58	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.34144249
59	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.33817823
60	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.32356164
61	P68_20966046_ChIP-Seq_HELA_Human	1.32309303
62	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.31957611
63	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.31469106
64	GABP_19822575_ChIP-Seq_HepG2_Human	1.29990794
65	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.28872359
66	XRN2_22483619_ChIP-Seq_HELA_Human	1.27159446
67	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.27050741
68	KDM5A_27292631_Chip-Seq_BREAST_Human	1.26129363
69	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.26127219
70	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.26045980
71	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.24442099
72	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.24320614
73	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.19806938
74	MYB_26560356_Chip-Seq_TH1_Human	1.19651653
75	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.18486869
76	GATA2_19941826_ChIP-Seq_K562_Human	1.17932449
77	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.17453554
78	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.14071800
79	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.13979527
80	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.13842085
81	RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.13500590
82	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.13230347
83	NCOR1_26117541_ChIP-Seq_K562_Human	1.11510467
84	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.11274659
85	TTF2_22483619_ChIP-Seq_HELA_Human	1.11257340
86	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.11016074
87	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.08603132
88	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.07206223
89	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.07057239
90	PHF8_20622854_ChIP-Seq_HELA_Human	1.06740711
91	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.06139215
92	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.05504738
93	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.03980331
94	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.03375897
95	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.01081499
96	MAF_26560356_Chip-Seq_TH1_Human	1.00723860
97	DCP1A_22483619_ChIP-Seq_HELA_Human	1.00413270
98	MYC_18940864_ChIP-ChIP_HL60_Human	0.99983425
99	CTCF_21964334_Chip-Seq_Bcells_Human	0.99918890
100	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.99416905

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001545_abnormal_hematopoietic_system	5.31596968
2	MP0005397_hematopoietic_system_phenotyp	5.31596968
3	MP0003656_abnormal_erythrocyte_physiolo	5.11625681
4	MP0004147_increased_porphyrin_level	4.41265459
5	MP0002396_abnormal_hematopoietic_system	3.39568421
6	MP0005451_abnormal_body_composition	3.08861097
7	MP0005083_abnormal_biliary_tract	3.01520596
8	MP0009278_abnormal_bone_marrow	2.92997278
9	MP0000465_gastrointestinal_hemorrhage	2.71522614
10	MP0002822_catalepsy	2.60374310
11	MP0005464_abnormal_platelet_physiology	2.58133225
12	MP0000372_irregular_coat_pigmentation	2.48184808
13	MP0005084_abnormal_gallbladder_morpholo	2.46459693
14	MP0005075_abnormal_melanosome_morpholog	2.29516848
15	MP0002653_abnormal_ependyma_morphology	2.24164172
16	MP0003806_abnormal_nucleotide_metabolis	2.11687368
17	MP0009384_cardiac_valve_regurgitation	2.11363804
18	MP0008058_abnormal_DNA_repair	2.04280637
19	MP0009697_abnormal_copulation	1.94671734
20	MP0003011_delayed_dark_adaptation	1.90978659
21	MP0004808_abnormal_hematopoietic_stem	1.67365712
22	MP0006276_abnormal_autonomic_nervous	1.66936942
23	MP0005367_renal/urinary_system_phenotyp	1.66474118
24	MP0000516_abnormal_urinary_system	1.66474118
25	MP0005410_abnormal_fertilization	1.59846877
26	MP0003315_abnormal_perineum_morphology	1.58520131
27	MP0005636_abnormal_mineral_homeostasis	1.56851409
28	MP0001873_stomach_inflammation	1.55135365
29	MP0002132_abnormal_respiratory_system	1.51583868
30	MP0000689_abnormal_spleen_morphology	1.47327928
31	MP0002398_abnormal_bone_marrow	1.45797082
32	MP0006036_abnormal_mitochondrial_physio	1.43663210
33	MP0003186_abnormal_redox_activity	1.38782796
34	MP0002722_abnormal_immune_system	1.38396496
35	MP0005646_abnormal_pituitary_gland	1.30522176
36	MP0008789_abnormal_olfactory_epithelium	1.29112914
37	MP0008961_abnormal_basal_metabolism	1.26231057
38	MP0000015_abnormal_ear_pigmentation	1.24037032
39	MP0003786_premature_aging	1.21131611
40	MP0003763_abnormal_thymus_physiology	1.16846383
41	MP0002019_abnormal_tumor_incidence	1.16033269
42	MP0003787_abnormal_imprinting	1.14880191
43	MP0008995_early_reproductive_senescence	1.14480500
44	MP0003646_muscle_fatigue	1.13479178
45	MP0005220_abnormal_exocrine_pancreas	1.10866033
46	MP0002638_abnormal_pupillary_reflex	1.10286800
47	MP0002429_abnormal_blood_cell	1.10037098
48	MP0009765_abnormal_xenobiotic_induced	1.08738972
49	MP0005394_taste/olfaction_phenotype	1.08370579
50	MP0005499_abnormal_olfactory_system	1.08370579
51	MP0002419_abnormal_innate_immunity	1.06203217
52	MP0003436_decreased_susceptibility_to	1.02526786
53	MP0009764_decreased_sensitivity_to	1.01587621
54	MP0010094_abnormal_chromosome_stability	1.01269957
55	MP0005025_abnormal_response_to	1.01266404
56	MP0001663_abnormal_digestive_system	1.00141241
57	MP0003866_abnormal_defecation	0.99708474
58	MP0003718_maternal_effect	0.99652355
59	MP0002420_abnormal_adaptive_immunity	0.97268367
60	MP0002148_abnormal_hypersensitivity_rea	0.96782013
61	MP0003724_increased_susceptibility_to	0.96293114
62	MP0004043_abnormal_pH_regulation	0.94708277
63	MP0000716_abnormal_immune_system	0.94365572
64	MP0001819_abnormal_immune_cell	0.94132890
65	MP0001905_abnormal_dopamine_level	0.92729998
66	MP0005000_abnormal_immune_tolerance	0.89086568
67	MP0002452_abnormal_antigen_presenting	0.88560040
68	MP0002723_abnormal_immune_serum	0.84582718
69	MP0001835_abnormal_antigen_presentation	0.82507826
70	MP0001800_abnormal_humoral_immune	0.81833322
71	MP0000230_abnormal_systemic_arterial	0.80988137
72	MP0008877_abnormal_DNA_methylation	0.80392737
73	MP0008770_decreased_survivor_rate	0.79857183
74	MP0008872_abnormal_physiological_respon	0.79660486
75	MP0002405_respiratory_system_inflammati	0.78952464
76	MP0009379_abnormal_foot_pigmentation	0.75617886
77	MP0003698_abnormal_male_reproductive	0.75272867
78	MP0005310_abnormal_salivary_gland	0.73567910
79	MP0008469_abnormal_protein_level	0.73500362
80	MP0005645_abnormal_hypothalamus_physiol	0.72853248
81	MP0000538_abnormal_urinary_bladder	0.71915771
82	MP0003121_genomic_imprinting	0.71700394
83	MP0010386_abnormal_urinary_bladder	0.71541496
84	MP0005165_increased_susceptibility_to	0.67736068
85	MP0008873_increased_physiological_sensi	0.67563031
86	MP0008007_abnormal_cellular_replicative	0.66883078
87	MP0000681_abnormal_thyroid_gland	0.65223807
88	MP0000703_abnormal_thymus_morphology	0.64755828
89	MP0004142_abnormal_muscle_tone	0.63366518
90	MP0003303_peritoneal_inflammation	0.63204478
91	MP0002095_abnormal_skin_pigmentation	0.62206851
92	MP0009763_increased_sensitivity_to	0.61320447
93	MP0001881_abnormal_mammary_gland	0.60737580
94	MP0001764_abnormal_homeostasis	0.60422394
95	MP0000598_abnormal_liver_morphology	0.60353036
96	MP0008875_abnormal_xenobiotic_pharmacok	0.60352915
97	MP0005381_digestive/alimentary_phenotyp	0.59747953
98	MP0005535_abnormal_body_temperature	0.57164281
99	MP0006292_abnormal_olfactory_placode	0.56852452
100	MP0005266_abnormal_metabolism	0.55901659

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the heme biosynthetic pathway (HP:0010472)	7.42444993
2	Prolonged bleeding time (HP:0003010)	5.89618907
3	Hyperthyroidism (HP:0000836)	4.49308285
4	Visual hallucinations (HP:0002367)	4.42274317
5	Thrombocytosis (HP:0001894)	4.40943657
6	Hypertensive crisis (HP:0100735)	4.35099686
7	Petechiae (HP:0000967)	4.26984939
8	Agammaglobulinemia (HP:0004432)	4.19196211
9	Aplastic anemia (HP:0001915)	4.16770350
10	Reticulocytosis (HP:0001923)	4.10784555
11	Purpura (HP:0000979)	3.86539808
12	Failure to thrive in infancy (HP:0001531)	3.76496569
13	Elevated erythrocyte sedimentation rate (HP:0003565)	3.58329710
14	Cerebral palsy (HP:0100021)	3.43663523
15	Epistaxis (HP:0000421)	3.39135044
16	Poikilocytosis (HP:0004447)	3.38970764
17	Increased intramyocellular lipid droplets (HP:0012240)	3.38401085
18	Abnormal number of erythroid precursors (HP:0012131)	3.35821153
19	Increased IgE level (HP:0003212)	3.22685443
20	Severe combined immunodeficiency (HP:0004430)	3.14380554
21	Chronic obstructive pulmonary disease (HP:0006510)	3.00010801
22	Obstructive lung disease (HP:0006536)	3.00010801
23	Acanthocytosis (HP:0001927)	2.98452738
24	Increased muscle lipid content (HP:0009058)	2.95806065
25	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.90994257
26	Abnormality of reticulocytes (HP:0004312)	2.90160899
27	Increased mean platelet volume (HP:0011877)	2.86890962
28	Abnormal mitochondria in muscle tissue (HP:0008316)	2.79988157
29	Abnormality of cells of the erythroid lineage (HP:0012130)	2.77100098
30	Granulocytopenia (HP:0001913)	2.76501109
31	Cellulitis (HP:0100658)	2.73882244
32	Abnormal platelet volume (HP:0011876)	2.67931273
33	Atelectasis (HP:0100750)	2.67439225
34	Seborrheic dermatitis (HP:0001051)	2.65516583
35	Progressive microcephaly (HP:0000253)	2.58993167
36	Oligomenorrhea (HP:0000876)	2.57508506
37	Truncus arteriosus (HP:0001660)	2.56189868
38	Cholecystitis (HP:0001082)	2.55937802
39	Abnormal gallbladder physiology (HP:0012438)	2.55937802
40	Cholelithiasis (HP:0001081)	2.55834389
41	Leukocytosis (HP:0001974)	2.55614166
42	Menorrhagia (HP:0000132)	2.54365840
43	B lymphocytopenia (HP:0010976)	2.52730858
44	Autoimmune thrombocytopenia (HP:0001973)	2.42881403
45	Recurrent fungal infections (HP:0002841)	2.42092231
46	Acute necrotizing encephalopathy (HP:0006965)	2.39553630
47	Combined immunodeficiency (HP:0005387)	2.38074211
48	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.37799719
49	Acute encephalopathy (HP:0006846)	2.35649175
50	Hyperbilirubinemia (HP:0002904)	2.30603143
51	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.27742598
52	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.27742598
53	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.27372080
54	Abnormal gallbladder morphology (HP:0012437)	2.26791048
55	Abnormality of B cell number (HP:0010975)	2.26175990
56	Abnormal hair whorl (HP:0010721)	2.21104942
57	Panhypogammaglobulinemia (HP:0003139)	2.18610405
58	Cutaneous photosensitivity (HP:0000992)	2.17290883
59	Abnormality of iron homeostasis (HP:0011031)	2.16903191
60	Paralysis (HP:0003470)	2.16805847
61	Type I transferrin isoform profile (HP:0003642)	2.16498705
62	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.16471818
63	Aplasia/Hypoplasia of the thymus (HP:0010515)	2.13961596
64	Mitochondrial inheritance (HP:0001427)	2.13672161
65	Microvesicular hepatic steatosis (HP:0001414)	2.13277429
66	Hypergammaglobulinemia (HP:0010702)	2.12992667
67	Microcytic anemia (HP:0001935)	2.08461844
68	Pallor (HP:0000980)	2.07621044
69	Abnormality of lateral ventricle (HP:0030047)	2.06816943
70	Generalized aminoaciduria (HP:0002909)	2.05542625
71	Vertebral compression fractures (HP:0002953)	2.05271701
72	Severe visual impairment (HP:0001141)	2.04381520
73	Increased serum ferritin (HP:0003281)	2.01586314
74	Eosinophilia (HP:0001880)	2.01327090
75	Abnormality of the columella (HP:0009929)	2.01228766
76	Erythema (HP:0010783)	2.00308186
77	Myositis (HP:0100614)	1.98613409
78	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.97186512
79	Muscle fiber atrophy (HP:0100295)	1.96994794
80	Gingival bleeding (HP:0000225)	1.96879716
81	Increased cerebral lipofuscin (HP:0011813)	1.95539753
82	Hepatocellular necrosis (HP:0001404)	1.95506691
83	Sepsis (HP:0100806)	1.95185087
84	Abnormality of transition element cation homeostasis (HP:0011030)	1.95106791
85	Growth hormone excess (HP:0000845)	1.94733183
86	Progressive macrocephaly (HP:0004481)	1.94448058
87	Increased CSF lactate (HP:0002490)	1.93622371
88	Acute lymphatic leukemia (HP:0006721)	1.92517422
89	Hypoparathyroidism (HP:0000829)	1.92488611
90	Brushfield spots (HP:0001088)	1.92299233
91	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.89802657
92	Abnormal protein N-linked glycosylation (HP:0012347)	1.89802657
93	Abnormal protein glycosylation (HP:0012346)	1.89802657
94	Abnormal glycosylation (HP:0012345)	1.89802657
95	Lactic acidosis (HP:0003128)	1.88035302
96	Focal motor seizures (HP:0011153)	1.86920643
97	Tubulointerstitial nephritis (HP:0001970)	1.82360413
98	High anterior hairline (HP:0009890)	1.82185455
99	Acne (HP:0001061)	1.81668491
100	Amyotrophic lateral sclerosis (HP:0007354)	1.81305213

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	7.58263512
2	VRK2	6.00782119
3	BCKDK	5.20966744
4	PIM2	4.44275674
5	KIT	3.31019876
6	KDR	2.75681634
7	MAP4K2	2.66995083
8	TESK2	2.56008645
9	NUAK1	2.11781946
10	ZAK	1.94167879
11	VRK1	1.88491518
12	TAOK3	1.74908355
13	JAK3	1.73066663
14	GRK6	1.68303202
15	ABL2	1.66429428
16	IRAK3	1.61425022
17	TAOK1	1.57023422
18	RAF1	1.50330728
19	MAP4K1	1.41364111
20	SYK	1.40519521
21	MAP3K11	1.35469026
22	ERN1	1.24865917
23	EIF2AK1	1.22544338
24	ARAF	1.17210697
25	FLT3	1.15811836
26	MAP2K3	1.14366431
27	PIM1	1.14122919
28	SCYL2	1.10430159
29	DYRK2	1.07420010
30	DYRK3	1.07220823
31	TESK1	1.04055436
32	PBK	0.99849065
33	MAP2K2	0.95072465
34	CDC7	0.93351014
35	EPHA3	0.87253429
36	TLK1	0.86984778
37	TNK2	0.86377433
38	IKBKB	0.76447905
39	RPS6KA5	0.75288272
40	MAPK13	0.74500784
41	CSNK1G3	0.72199122
42	MAP3K1	0.70264507
43	PRKCQ	0.67710042
44	CSNK1G2	0.66380064
45	BLK	0.63724096
46	MATK	0.62180824
47	PIK3CG	0.61996699
48	LYN	0.61901874
49	TBK1	0.60880528
50	TAOK2	0.58999235
51	RIPK4	0.57514137
52	NLK	0.56339696
53	FES	0.55309771
54	CSNK1G1	0.54237809
55	PAK2	0.52395565
56	TRIM28	0.52112147
57	PTK2B	0.49833764
58	CSF1R	0.49793925
59	INSRR	0.46169631
60	BTK	0.45995409
61	CSNK1A1L	0.45773102
62	HIPK2	0.45538303
63	LCK	0.44913943
64	ATR	0.41491228
65	DYRK1B	0.40961589
66	MAP2K6	0.38618569
67	RPS6KA6	0.38383426
68	RPS6KC1	0.36848576
69	RPS6KL1	0.36848576
70	RPS6KA4	0.36595411
71	MAP3K5	0.35767474
72	DAPK1	0.35139502
73	CCNB1	0.34610086
74	MELK	0.33630641
75	PINK1	0.30200537
76	GRK5	0.29403042
77	SRPK1	0.28451770
78	MAPK3	0.27534929
79	BMPR1B	0.27467377
80	CSNK1A1	0.26853705
81	CSNK2A1	0.26531721
82	ATM	0.25997402
83	CSNK2A2	0.25834316
84	JAK2	0.25368435
85	CLK1	0.25017237
86	CHEK2	0.23488067
87	ZAP70	0.22800865
88	CDK2	0.22662407
89	PRKCZ	0.20953665
90	MAPK12	0.20329480
91	MAPK4	0.20131901
92	MAPK11	0.16537521
93	PRKACA	0.15936843
94	DAPK3	0.15528262
95	PRKCD	0.15298327
96	BMPR2	0.14682976
97	CDK7	0.14302391
98	PRKCI	0.14146183
99	CAMK2G	0.13428562
100	GSK3A	0.13258787

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	3.99999287
2	DNA replication_Homo sapiens_hsa03030	2.88304038
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.83692049
4	Primary immunodeficiency_Homo sapiens_hsa05340	2.46303688
5	Parkinsons disease_Homo sapiens_hsa05012	2.46142575
6	Homologous recombination_Homo sapiens_hsa03440	2.42336620
7	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.41238347
8	Proteasome_Homo sapiens_hsa03050	2.38673932
9	Non-homologous end-joining_Homo sapiens_hsa03450	2.30908745
10	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	2.28404663
11	Asthma_Homo sapiens_hsa05310	2.09157149
12	Fanconi anemia pathway_Homo sapiens_hsa03460	2.06997488
13	Ribosome_Homo sapiens_hsa03010	2.04231428
14	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.99610853
15	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.89047127
16	Oxidative phosphorylation_Homo sapiens_hsa00190	1.82698048
17	Spliceosome_Homo sapiens_hsa03040	1.80826922
18	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.78175152
19	Sulfur relay system_Homo sapiens_hsa04122	1.71602393
20	Allograft rejection_Homo sapiens_hsa05330	1.71011983
21	Renin-angiotensin system_Homo sapiens_hsa04614	1.70110961
22	Peroxisome_Homo sapiens_hsa04146	1.67762363
23	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.65843208
24	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.55208427
25	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.53610444
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.51143767
27	Purine metabolism_Homo sapiens_hsa00230	1.50152043
28	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.49900502
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.46785018
30	Platelet activation_Homo sapiens_hsa04611	1.42507467
31	Base excision repair_Homo sapiens_hsa03410	1.38163703
32	Graft-versus-host disease_Homo sapiens_hsa05332	1.35700304
33	Type I diabetes mellitus_Homo sapiens_hsa04940	1.34910324
34	Mismatch repair_Homo sapiens_hsa03430	1.33286504
35	Huntingtons disease_Homo sapiens_hsa05016	1.31081065
36	Glutathione metabolism_Homo sapiens_hsa00480	1.30360245
37	Propanoate metabolism_Homo sapiens_hsa00640	1.27472361
38	Acute myeloid leukemia_Homo sapiens_hsa05221	1.25510817
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.19452803
40	Antigen processing and presentation_Homo sapiens_hsa04612	1.18945782
41	Nucleotide excision repair_Homo sapiens_hsa03420	1.13011892
42	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.12655753
43	Carbon metabolism_Homo sapiens_hsa01200	1.12329998
44	Viral myocarditis_Homo sapiens_hsa05416	1.11615046
45	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.11311017
46	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.00271164
47	Herpes simplex infection_Homo sapiens_hsa05168	0.99037032
48	Leishmaniasis_Homo sapiens_hsa05140	0.98664405
49	Regulation of autophagy_Homo sapiens_hsa04140	0.91670830
50	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.91363347
51	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.90022529
52	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.89025715
53	African trypanosomiasis_Homo sapiens_hsa05143	0.86778646
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.86162779
55	RNA polymerase_Homo sapiens_hsa03020	0.85332755
56	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.82290603
57	Pentose phosphate pathway_Homo sapiens_hsa00030	0.81852497
58	RNA transport_Homo sapiens_hsa03013	0.80731332
59	Metabolic pathways_Homo sapiens_hsa01100	0.79043167
60	Alzheimers disease_Homo sapiens_hsa05010	0.78221978
61	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.78029440
62	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.77562948
63	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.74094735
64	Fatty acid elongation_Homo sapiens_hsa00062	0.71745577
65	Olfactory transduction_Homo sapiens_hsa04740	0.71272757
66	Sulfur metabolism_Homo sapiens_hsa00920	0.69907778
67	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.69870024
68	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.68997345
69	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.66538726
70	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.66267118
71	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.65328127
72	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.63180318
73	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.62087581
74	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.61663908
75	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.58935539
76	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.58195799
77	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.57641980
78	Fatty acid metabolism_Homo sapiens_hsa01212	0.56454712
79	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.51913663
80	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.51672816
81	Cardiac muscle contraction_Homo sapiens_hsa04260	0.50002192
82	Salivary secretion_Homo sapiens_hsa04970	0.48300822
83	Tyrosine metabolism_Homo sapiens_hsa00350	0.45460630
84	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.43863298
85	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.43699828
86	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.40316609
87	Tuberculosis_Homo sapiens_hsa05152	0.39604771
88	Chemical carcinogenesis_Homo sapiens_hsa05204	0.38791318
89	Influenza A_Homo sapiens_hsa05164	0.37586620
90	Measles_Homo sapiens_hsa05162	0.35062345
91	Rheumatoid arthritis_Homo sapiens_hsa05323	0.33975423
92	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.33359889
93	Toxoplasmosis_Homo sapiens_hsa05145	0.30339575
94	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.29785916
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.26544996
96	p53 signaling pathway_Homo sapiens_hsa04115	0.26299422
97	Folate biosynthesis_Homo sapiens_hsa00790	0.25974531
98	Calcium signaling pathway_Homo sapiens_hsa04020	0.25408013
99	ABC transporters_Homo sapiens_hsa02010	0.23077464
100	Protein digestion and absorption_Homo sapiens_hsa04974	0.23027873

OR2T32P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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