OR2W3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oxygen transport (GO:0015671)6.75771820
2hemoglobin metabolic process (GO:0020027)6.64685292
3protoporphyrinogen IX metabolic process (GO:0046501)6.51680549
4neutrophil activation involved in immune response (GO:0002283)6.09208067
5gas transport (GO:0015669)5.57345142
6protoporphyrinogen IX biosynthetic process (GO:0006782)5.14819776
7regulation of platelet aggregation (GO:0090330)5.10869869
8positive regulation of gamma-delta T cell activation (GO:0046645)4.90507463
9positive regulation by symbiont of host defense response (GO:0052509)4.89222642
10modulation by symbiont of host defense response (GO:0052031)4.89222642
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.89222642
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.89222642
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.89222642
14modulation by symbiont of host immune response (GO:0052553)4.89222642
15erythrocyte development (GO:0048821)4.87722297
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.86643069
17negative regulation of cell killing (GO:0031342)4.86643069
18erythrocyte maturation (GO:0043249)4.62973047
19heme biosynthetic process (GO:0006783)4.54665739
20regulation of B cell receptor signaling pathway (GO:0050855)4.50582074
21positive regulation of granulocyte differentiation (GO:0030854)4.45819064
22porphyrin-containing compound biosynthetic process (GO:0006779)4.44472278
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.38599342
24negative regulation of erythrocyte differentiation (GO:0045647)4.27161423
25positive regulation of fibroblast migration (GO:0010763)4.26596064
26myeloid cell development (GO:0061515)4.20654791
27neutrophil activation (GO:0042119)4.16013622
283-UTR-mediated mRNA stabilization (GO:0070935)3.96300261
29positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.93718071
30modulation by virus of host process (GO:0019054)3.86085952
31tetrapyrrole biosynthetic process (GO:0033014)3.83532493
32regulation of mast cell degranulation (GO:0043304)3.83078398
33detection of other organism (GO:0098543)3.82377103
34granulocyte activation (GO:0036230)3.81154031
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.81066113
36microglial cell activation (GO:0001774)3.78943741
37detection of bacterium (GO:0016045)3.73679176
38hepatocyte apoptotic process (GO:0097284)3.71779719
39porphyrin-containing compound metabolic process (GO:0006778)3.71446388
40antigen processing and presentation of endogenous antigen (GO:0019883)3.67617129
41response to peptidoglycan (GO:0032494)3.66037229
42megakaryocyte development (GO:0035855)3.64696869
43heme metabolic process (GO:0042168)3.64449751
44positive regulation of mast cell activation (GO:0033005)3.56326218
45regulation of mast cell activation involved in immune response (GO:0033006)3.52000751
46response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.49952211
47response to host immune response (GO:0052572)3.49952211
48leukocyte migration involved in inflammatory response (GO:0002523)3.49389253
49macrophage activation involved in immune response (GO:0002281)3.48295417
50leukocyte degranulation (GO:0043299)3.47357295
51regulation of myeloid leukocyte mediated immunity (GO:0002886)3.43461816
52negative regulation of phagocytosis (GO:0050765)3.42167304
53positive regulation of B cell differentiation (GO:0045579)3.39878040
54cellular extravasation (GO:0045123)3.39220068
55myeloid cell activation involved in immune response (GO:0002275)3.36835775
56modulation by symbiont of host cellular process (GO:0044068)3.36112012
57negative regulation of lymphocyte mediated immunity (GO:0002707)3.33224246
58negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.30916421
59negative regulation of interleukin-12 production (GO:0032695)3.29684076
60leukocyte aggregation (GO:0070486)3.29158898
61regulation of leukocyte degranulation (GO:0043300)3.27464065
62regulation of gamma-delta T cell activation (GO:0046643)3.26667535
63response to interleukin-15 (GO:0070672)3.21984690
64regulation of mast cell activation (GO:0033003)3.21579232
65definitive hemopoiesis (GO:0060216)3.19853003
66regulation of granulocyte differentiation (GO:0030852)3.19805095
67response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.18264668
68response to host (GO:0075136)3.18264668
69response to host defenses (GO:0052200)3.18264668
70cellular response to virus (GO:0098586)3.17479332
71antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.15184832
72regulation of platelet activation (GO:0010543)3.12957702
73detection of external biotic stimulus (GO:0098581)3.12566652
74respiratory burst (GO:0045730)3.10042182
75positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.07721274
76negative regulation of leukocyte mediated immunity (GO:0002704)3.05965848
77neutrophil mediated immunity (GO:0002446)3.05903245
78negative regulation of execution phase of apoptosis (GO:1900118)3.05493636
79regulation of interferon-beta biosynthetic process (GO:0045357)3.04601150
80B cell receptor signaling pathway (GO:0050853)3.03361077
81regulation of B cell differentiation (GO:0045577)3.02421396
82regulation of gamma-delta T cell differentiation (GO:0045586)2.96230922
83macrophage activation (GO:0042116)2.95769508
84negative regulation of T cell mediated immunity (GO:0002710)2.95393904
85regulation of response to osmotic stress (GO:0047484)2.94516853
86detection of molecule of bacterial origin (GO:0032490)2.86795518
87regulation of erythrocyte differentiation (GO:0045646)2.86063655
88immunoglobulin mediated immune response (GO:0016064)2.85608558
89negative regulation of glial cell proliferation (GO:0060253)2.84137008
90regulation of regulated secretory pathway (GO:1903305)2.81506228
91negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.80215320
92tolerance induction (GO:0002507)2.78982302
93viral protein processing (GO:0019082)2.77568993
94regulation of homotypic cell-cell adhesion (GO:0034110)2.76029860
95cellular response to interleukin-15 (GO:0071350)2.75638904
96positive thymic T cell selection (GO:0045059)2.73371035
97platelet formation (GO:0030220)2.71540083
98positive regulation of interleukin-17 production (GO:0032740)2.70376249
99granulocyte differentiation (GO:0030851)2.70309273
100negative regulation of stress fiber assembly (GO:0051497)2.68846721

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human4.71401921
2SCL_19346495_ChIP-Seq_HPC-7_Human4.10793750
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.88009488
4GATA1_19941826_ChIP-Seq_K562_Human3.84666236
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.39236958
6RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.95297399
7MYB_21317192_ChIP-Seq_ERMYB_Mouse2.93091345
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.82364222
9TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.80730586
10GATA1_19941827_ChIP-Seq_MEL_Mouse2.80103433
11GATA2_19941826_ChIP-Seq_K562_Human2.67369241
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.66827288
13VDR_21846776_ChIP-Seq_THP-1_Human2.63737703
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.61623645
15SPI1_23127762_ChIP-Seq_K562_Human2.55428322
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.51398776
17MYC_22102868_ChIP-Seq_BL_Human2.50407322
18RUNX1_22412390_ChIP-Seq_EML_Mouse2.49213561
19SPI1_23547873_ChIP-Seq_NB4_Human2.43118200
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.42148923
21VDR_24763502_ChIP-Seq_THP-1_Human2.38514057
22SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.37571933
23MAF_26560356_Chip-Seq_TH1_Human2.36428978
24UTX_26944678_Chip-Seq_JUKART_Human2.30083623
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.25313757
26GATA1_22383799_ChIP-Seq_G1ME_Mouse2.24250782
27TCF7_22412390_ChIP-Seq_EML_Mouse2.22317710
28MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.21897116
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.18334002
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.14527693
31RUNX_20019798_ChIP-Seq_JUKART_Human2.13055084
32LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.11904645
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.11072091
34MYB_26560356_Chip-Seq_TH2_Human2.08861534
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.06624247
36BRD4_27068464_Chip-Seq_AML-cells_Mouse2.05977194
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.05425526
38* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.02999463
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.98606590
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.89887421
41MYB_26560356_Chip-Seq_TH1_Human1.89413336
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.89321253
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.88244092
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.85483902
45KDM2B_26808549_Chip-Seq_DND41_Human1.84899877
46KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.84861201
47* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.81295900
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.80472219
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.80231983
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78378858
51GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.69956532
52NCOR1_26117541_ChIP-Seq_K562_Human1.67262143
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.65743554
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65625613
55MAF_26560356_Chip-Seq_TH2_Human1.65266011
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64611961
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.63778135
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.61732117
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.59069336
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56142882
61GATA3_27048872_Chip-Seq_THYMUS_Human1.55112194
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.55071759
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52326533
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41102439
65CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35583576
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31886985
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29078993
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28910258
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27216250
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.25129706
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24795202
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.24056723
73BCL6_27268052_Chip-Seq_Bcells_Human1.20252479
74NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16571594
75PU_27001747_Chip-Seq_BMDM_Mouse1.16459196
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16264539
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15212637
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15176447
79PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14314576
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.13866137
81CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13202505
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.12932928
83BCOR_27268052_Chip-Seq_Bcells_Human1.10849759
84RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10798486
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06822462
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06025791
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05320099
88LXR_22292898_ChIP-Seq_THP-1_Human1.05080052
89GATA1_19941827_ChIP-Seq_MEL86_Mouse1.03757389
90FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.03513847
91CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00131841
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97550609
93SPI1_20517297_ChIP-Seq_HL60_Human0.95516960
94CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95350384
95PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95070284
96IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92949230
97SA1_27219007_Chip-Seq_ERYTHROID_Human0.91320642
98VDR_24787735_ChIP-Seq_THP-1_Human0.90038920
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89439495
100GATA3_26560356_Chip-Seq_TH2_Human0.87289086

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology4.53254589
2MP0003656_abnormal_erythrocyte_physiolo4.39554363
3MP0003724_increased_susceptibility_to3.99169404
4MP0003303_peritoneal_inflammation3.75316877
5MP0003436_decreased_susceptibility_to3.43442587
6MP0005083_abnormal_biliary_tract3.27059638
7MP0004147_increased_porphyrin_level2.89742246
8MP0001835_abnormal_antigen_presentation2.77921410
9MP0008260_abnormal_autophagy2.52397771
10MP0002419_abnormal_innate_immunity2.49175048
11MP0005397_hematopoietic_system_phenotyp2.46699980
12MP0001545_abnormal_hematopoietic_system2.46699980
13MP0002132_abnormal_respiratory_system2.38358553
14MP0005025_abnormal_response_to2.33217482
15MP0005000_abnormal_immune_tolerance2.27212249
16MP0000685_abnormal_immune_system2.27017753
17MP0000465_gastrointestinal_hemorrhage2.26530696
18MP0002398_abnormal_bone_marrow2.18301389
19MP0001800_abnormal_humoral_immune2.17694453
20MP0001790_abnormal_immune_system2.16712543
21MP0005387_immune_system_phenotype2.16712543
22MP0005671_abnormal_response_to2.13596063
23MP0002420_abnormal_adaptive_immunity2.13303132
24MP0001819_abnormal_immune_cell2.10577109
25MP0003300_gastrointestinal_ulcer2.06426849
26MP0003172_abnormal_lysosome_physiology2.02578106
27MP0002723_abnormal_immune_serum2.01054133
28MP0003763_abnormal_thymus_physiology2.00028107
29MP0008004_abnormal_stomach_pH1.97843577
30MP0002405_respiratory_system_inflammati1.94705609
31MP0003191_abnormal_cellular_cholesterol1.94413471
32MP0009278_abnormal_bone_marrow1.94188173
33MP0009785_altered_susceptibility_to1.91923378
34MP0002452_abnormal_antigen_presenting1.90850496
35MP0002148_abnormal_hypersensitivity_rea1.82746338
36MP0006082_CNS_inflammation1.79919061
37MP0000689_abnormal_spleen_morphology1.78644991
38MP0002722_abnormal_immune_system1.77939327
39MP0003866_abnormal_defecation1.68815368
40MP0000716_abnormal_immune_system1.68025669
41MP0010155_abnormal_intestine_physiology1.67360208
42MP0002429_abnormal_blood_cell1.63477408
43MP0002396_abnormal_hematopoietic_system1.62206928
44MP0004947_skin_inflammation1.59077663
45MP0001533_abnormal_skeleton_physiology1.57448480
46MP0005075_abnormal_melanosome_morpholog1.51261826
47MP0000703_abnormal_thymus_morphology1.49206602
48MP0009333_abnormal_splenocyte_physiolog1.48924831
49MP0003828_pulmonary_edema1.46154520
50MP0004808_abnormal_hematopoietic_stem1.43055941
51MP0001851_eye_inflammation1.40950152
52MP0000015_abnormal_ear_pigmentation1.37548372
53MP0001845_abnormal_inflammatory_respons1.37006775
54MP0009764_decreased_sensitivity_to1.34240697
55MP0005310_abnormal_salivary_gland1.30426816
56MP0005451_abnormal_body_composition1.28039588
57MP0004510_myositis1.22486914
58MP0001663_abnormal_digestive_system1.17221365
59MP0000858_altered_metastatic_potential1.14957803
60MP0004381_abnormal_hair_follicle1.13729229
61MP0000343_altered_response_to1.13200262
62MP0000490_abnormal_crypts_of1.12116059
63MP0008469_abnormal_protein_level1.07909952
64MP0005377_hearing/vestibular/ear_phenot1.06497624
65MP0003878_abnormal_ear_physiology1.06497624
66MP0005058_abnormal_lysosome_morphology0.99840723
67MP0009763_increased_sensitivity_to0.98835886
68MP0001873_stomach_inflammation0.96085161
69MP0004130_abnormal_muscle_cell0.95801617
70MP0003566_abnormal_cell_adhesion0.93868747
71MP0009765_abnormal_xenobiotic_induced0.92810101
72MP0003806_abnormal_nucleotide_metabolis0.91835350
73MP0002332_abnormal_exercise_endurance0.91832025
74MP0008874_decreased_physiological_sensi0.90998173
75MP0002653_abnormal_ependyma_morphology0.90455276
76MP0003075_altered_response_to0.87207541
77MP0004883_abnormal_blood_vessel0.86491175
78MP0003186_abnormal_redox_activity0.81613339
79MP0005174_abnormal_tail_pigmentation0.80735532
80MP0003453_abnormal_keratinocyte_physiol0.79384496
81MP0006035_abnormal_mitochondrial_morpho0.76938566
82MP0002998_abnormal_bone_remodeling0.75163973
83MP0003183_abnormal_peptide_metabolism0.74642595
84MP0002019_abnormal_tumor_incidence0.70318603
85MP0005636_abnormal_mineral_homeostasis0.69282350
86MP0009931_abnormal_skin_appearance0.68791689
87MP0005381_digestive/alimentary_phenotyp0.68311903
88MP0005164_abnormal_response_to0.66843121
89MP0003943_abnormal_hepatobiliary_system0.64293488
90MP0000249_abnormal_blood_vessel0.62667410
91MP0003045_fibrosis0.60984059
92MP0005166_decreased_susceptibility_to0.58162823
93MP0003795_abnormal_bone_structure0.55327165
94MP0002166_altered_tumor_susceptibility0.54725197
95MP0005084_abnormal_gallbladder_morpholo0.52872380
96MP0000313_abnormal_cell_death0.52391498
97MP0008995_early_reproductive_senescence0.51814178
98MP0005319_abnormal_enzyme/_coenzyme0.51140651
99MP0001915_intracranial_hemorrhage0.50953441
100MP0005390_skeleton_phenotype0.50861866

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)8.89988553
2Prolonged bleeding time (HP:0003010)6.89843848
3Hypochromic anemia (HP:0001931)6.27312008
4Microcytic anemia (HP:0001935)5.78674280
5Poikilocytosis (HP:0004447)5.29247086
6Petechiae (HP:0000967)5.19913691
7Abnormal platelet volume (HP:0011876)4.86371396
8Eczematoid dermatitis (HP:0000976)4.75974659
9Epistaxis (HP:0000421)4.53604986
10Recurrent abscess formation (HP:0002722)4.49843978
11Gingival bleeding (HP:0000225)4.27215178
12Abnormal hemoglobin (HP:0011902)4.27207420
13Recurrent bacterial skin infections (HP:0005406)4.25342355
14Increased mean platelet volume (HP:0011877)4.24087117
15Stomatitis (HP:0010280)4.23479137
16Purpura (HP:0000979)4.13932101
17Abnormality of macrophages (HP:0004311)4.11271720
18Myositis (HP:0100614)3.91039229
19Spontaneous hematomas (HP:0007420)3.89185922
20Menorrhagia (HP:0000132)3.86212396
21Urticaria (HP:0001025)3.62137893
22Obstructive lung disease (HP:0006536)3.59423713
23Chronic obstructive pulmonary disease (HP:0006510)3.59423713
24Polycythemia (HP:0001901)3.57417225
25Cholelithiasis (HP:0001081)3.56285108
26Elevated erythrocyte sedimentation rate (HP:0003565)3.51625568
27Acanthocytosis (HP:0001927)3.42664938
28Gastrointestinal infarctions (HP:0005244)3.39481130
29Orchitis (HP:0100796)3.39357800
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.33223797
31Reticulocytosis (HP:0001923)3.27000219
32Abnormal delayed hypersensitivity skin test (HP:0002963)3.22694229
33Recurrent gram-negative bacterial infections (HP:0005420)3.17532701
34Abnormal gallbladder morphology (HP:0012437)3.16818332
35Encephalitis (HP:0002383)3.03031456
36Optic neuritis (HP:0100653)2.99683186
37Retrobulbar optic neuritis (HP:0100654)2.99683186
38Episodic fever (HP:0001954)2.97921258
39Abnormal platelet function (HP:0011869)2.92849980
40Impaired platelet aggregation (HP:0003540)2.92849980
41Inflammation of the large intestine (HP:0002037)2.90241074
42Recurrent fungal infections (HP:0002841)2.88999053
43Toxemia of pregnancy (HP:0100603)2.88516187
44Abnormality of iron homeostasis (HP:0011031)2.84948662
45Meningitis (HP:0001287)2.84825696
46Gastrointestinal inflammation (HP:0004386)2.84603363
47Increased IgE level (HP:0003212)2.79923377
48Recurrent skin infections (HP:0001581)2.74687876
49Pustule (HP:0200039)2.72640658
50Increased serum ferritin (HP:0003281)2.59370646
51Cellulitis (HP:0100658)2.58289713
52Gingivitis (HP:0000230)2.58283859
53Slow saccadic eye movements (HP:0000514)2.57611211
54Increased IgM level (HP:0003496)2.56042221
55Chest pain (HP:0100749)2.53615918
56Mediastinal lymphadenopathy (HP:0100721)2.50505268
57Vasculitis (HP:0002633)2.49387381
58Paralysis (HP:0003470)2.45527941
59Panhypogammaglobulinemia (HP:0003139)2.43702017
60Leukocytosis (HP:0001974)2.43470683
61Keratoconjunctivitis sicca (HP:0001097)2.41305319
62Abnormality of transition element cation homeostasis (HP:0011030)2.40269100
63Cholecystitis (HP:0001082)2.38128166
64Abnormal gallbladder physiology (HP:0012438)2.38128166
65Chronic mucocutaneous candidiasis (HP:0002728)2.35063798
66Recurrent cutaneous fungal infections (HP:0011370)2.35063798
67Osteomyelitis (HP:0002754)2.33803783
68Bruising susceptibility (HP:0000978)2.25649800
69Anorexia (HP:0002039)2.23199433
70Keratoconjunctivitis (HP:0001096)2.22452793
71Abnormality of the gallbladder (HP:0005264)2.20401199
72Hematochezia (HP:0002573)2.17851443
73Arterial thrombosis (HP:0004420)2.16985516
74Granulocytopenia (HP:0001913)2.13647617
75Recurrent viral infections (HP:0004429)2.10788623
76Severe visual impairment (HP:0001141)2.04384339
77Abnormality of T cells (HP:0002843)2.03379708
78Hypochromic microcytic anemia (HP:0004840)10.0588878
79Hepatosplenomegaly (HP:0001433)1.99908421
80Cutaneous photosensitivity (HP:0000992)1.97950030
81T lymphocytopenia (HP:0005403)1.97771548
82Abnormality of T cell physiology (HP:0011840)1.96194017
83Peritonitis (HP:0002586)1.95933155
84Autoimmune hemolytic anemia (HP:0001890)1.95505012
85Abnormality of T cell number (HP:0011839)1.89674552
86Abnormality of the fingertips (HP:0001211)1.89433023
87Increased density of long bones (HP:0006392)1.89254024
88Abnormality of reticulocytes (HP:0004312)1.87955548
89Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.87815762
90Pulmonary embolism (HP:0002204)1.85523143
91Ileus (HP:0002595)1.81226370
92Hypergammaglobulinemia (HP:0010702)1.80034150
93Pulmonary infiltrates (HP:0002113)1.79369127
94Visual hallucinations (HP:0002367)1.77695832
95Nasal polyposis (HP:0100582)1.74790715
96Diplopia (HP:0000651)1.71498599
97Abnormality of binocular vision (HP:0011514)1.71498599
98Postural instability (HP:0002172)1.71203182
99Colitis (HP:0002583)1.70720715
100Albinism (HP:0001022)1.68925377

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.84034667
2MAP2K34.01545812
3GRK63.41112599
4TAOK13.28906407
5EIF2AK13.22707416
6MAP4K12.86860903
7TAOK22.78758958
8MAP3K112.76709092
9MAP3K32.75863726
10TNK22.49846290
11FES2.43786398
12ERN12.30896652
13IRAK42.12475142
14FGR2.00540066
15PRPF4B1.99500413
16BTK1.99018884
17BLK1.96812462
18SYK1.96279630
19ZAP701.92648637
20CSK1.84898453
21HCK1.84203374
22PTK2B1.80380102
23BMX1.78533312
24MAP3K11.55941806
25TYK21.46417618
26EPHB11.42465323
27SIK31.35024025
28MARK31.31380070
29JAK31.31151899
30LYN1.28188405
31TAOK31.23787974
32TEC1.23297405
33TXK1.21946909
34IKBKE1.19642327
35PIM11.10545832
36JAK21.08094469
37TBK11.02446531
38KSR21.01588471
39HIPK21.00582159
40PRKD21.00224956
41GRK50.98071812
42CSF1R0.97026064
43BMPR20.96446200
44DYRK30.96219974
45MARK20.94934702
46LCK0.90155307
47MAP3K50.90012846
48YES10.86025910
49PTK60.84678903
50IKBKB0.84188544
51MATK0.83522968
52ITK0.81909767
53TESK20.81493132
54SGK30.78839885
55PDK10.76401558
56TRIB30.74106152
57KIT0.70554009
58STK40.70279440
59DYRK1B0.68932634
60CLK10.68119845
61PDPK10.67305949
62CDK190.64486959
63SMG10.64456448
64SGK20.60319742
65STK110.60225802
66JAK10.55993233
67WNK10.55853189
68FYN0.54626629
69KSR10.53408157
70SIK20.53360266
71STK100.52895292
72MAP3K80.52575701
73PIK3CG0.52571591
74IRAK10.51337066
75IRAK20.50192302
76MAPK120.50030853
77STK380.46205821
78MAPKAPK20.45521221
79RPS6KC10.44046520
80RPS6KL10.44046520
81MAP3K70.42429266
82RAF10.39804338
83PRKCQ0.39716902
84RET0.37722042
85MAP3K20.37258025
86ICK0.37245426
87MAP3K60.36610468
88MAP2K40.36065975
89RPS6KA60.34226371
90LRRK20.34112627
91DAPK20.33333899
92MAP3K140.33012096
93TRPM70.24580018
94GSK3A0.23484207
95PRKG20.22966624
96MAP3K130.21745010
97MAPK70.21085712
98SIK10.20949073
99SGK4940.20006609
100SGK2230.20006609

Predicted pathways (KEGG)

RankGene SetZ-score
1Malaria_Homo sapiens_hsa051443.11407427
2Osteoclast differentiation_Homo sapiens_hsa043802.59628762
3Platelet activation_Homo sapiens_hsa046112.29277888
4Leishmaniasis_Homo sapiens_hsa051402.25796238
5B cell receptor signaling pathway_Homo sapiens_hsa046622.25169781
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.15656799
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.13994647
8Acute myeloid leukemia_Homo sapiens_hsa052212.05990786
9Hematopoietic cell lineage_Homo sapiens_hsa046402.05246426
10Primary immunodeficiency_Homo sapiens_hsa053401.96002964
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.90282114
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.86883133
13Non-small cell lung cancer_Homo sapiens_hsa052231.85571916
14African trypanosomiasis_Homo sapiens_hsa051431.85311377
15Pancreatic cancer_Homo sapiens_hsa052121.80483830
16Chemokine signaling pathway_Homo sapiens_hsa040621.76897840
17Staphylococcus aureus infection_Homo sapiens_hsa051501.76586675
18Tuberculosis_Homo sapiens_hsa051521.73146310
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.71811744
20Chronic myeloid leukemia_Homo sapiens_hsa052201.64883572
21T cell receptor signaling pathway_Homo sapiens_hsa046601.61950428
22Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.58531242
23Measles_Homo sapiens_hsa051621.57053376
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.49697623
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.44248843
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39250106
27Graft-versus-host disease_Homo sapiens_hsa053321.39091554
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.38998401
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.38106859
30Allograft rejection_Homo sapiens_hsa053301.36220570
31Toxoplasmosis_Homo sapiens_hsa051451.34682877
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.27551249
33Herpes simplex infection_Homo sapiens_hsa051681.24317500
34Regulation of autophagy_Homo sapiens_hsa041401.23489834
35Autoimmune thyroid disease_Homo sapiens_hsa053201.21044174
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.19547388
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19044102
38Influenza A_Homo sapiens_hsa051641.18885828
39Glycerophospholipid metabolism_Homo sapiens_hsa005641.11533211
40Phagosome_Homo sapiens_hsa041451.09001612
41Shigellosis_Homo sapiens_hsa051311.08923655
42VEGF signaling pathway_Homo sapiens_hsa043701.08922970
43Apoptosis_Homo sapiens_hsa042101.07005126
44Hepatitis B_Homo sapiens_hsa051611.05904379
45Adipocytokine signaling pathway_Homo sapiens_hsa049201.05479167
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05138033
47Renal cell carcinoma_Homo sapiens_hsa052111.04600208
48Endocytosis_Homo sapiens_hsa041441.04071408
49Legionellosis_Homo sapiens_hsa051341.02383052
50Hepatitis C_Homo sapiens_hsa051601.00338771
51Collecting duct acid secretion_Homo sapiens_hsa049660.99017744
52TNF signaling pathway_Homo sapiens_hsa046680.97354113
53Endometrial cancer_Homo sapiens_hsa052130.96735320
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95946047
55Choline metabolism in cancer_Homo sapiens_hsa052310.94300952
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90521813
57Antigen processing and presentation_Homo sapiens_hsa046120.88715198
58FoxO signaling pathway_Homo sapiens_hsa040680.87767355
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87621154
60Salmonella infection_Homo sapiens_hsa051320.84431838
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83618045
62Type I diabetes mellitus_Homo sapiens_hsa049400.82062800
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.80892589
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79906266
65Inositol phosphate metabolism_Homo sapiens_hsa005620.79548345
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.78032687
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75979966
68Viral myocarditis_Homo sapiens_hsa054160.75180772
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73845381
70Viral carcinogenesis_Homo sapiens_hsa052030.72505126
71mTOR signaling pathway_Homo sapiens_hsa041500.72339489
72Prolactin signaling pathway_Homo sapiens_hsa049170.71088883
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.70843966
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68423253
75Notch signaling pathway_Homo sapiens_hsa043300.65358390
76Thyroid cancer_Homo sapiens_hsa052160.64652008
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63712534
78Small cell lung cancer_Homo sapiens_hsa052220.62922157
79Glioma_Homo sapiens_hsa052140.61345380
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61209407
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60604104
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60323516
83HIF-1 signaling pathway_Homo sapiens_hsa040660.59346729
84Colorectal cancer_Homo sapiens_hsa052100.58099399
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57198334
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.55483994
87Rap1 signaling pathway_Homo sapiens_hsa040150.54730131
88HTLV-I infection_Homo sapiens_hsa051660.54070329
89Epstein-Barr virus infection_Homo sapiens_hsa051690.53183161
90MAPK signaling pathway_Homo sapiens_hsa040100.53056237
91Other glycan degradation_Homo sapiens_hsa005110.51947933
92Amoebiasis_Homo sapiens_hsa051460.51592600
93GnRH signaling pathway_Homo sapiens_hsa049120.50743601
94Rheumatoid arthritis_Homo sapiens_hsa053230.50427865
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48427914
96ErbB signaling pathway_Homo sapiens_hsa040120.48102914
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46006036
98Asthma_Homo sapiens_hsa053100.45977511
99AMPK signaling pathway_Homo sapiens_hsa041520.44595597
100Pertussis_Homo sapiens_hsa051330.43508118

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