OR2W5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1seminiferous tubule development (GO:0072520)9.86272750
2positive regulation of RNA splicing (GO:0033120)9.83706674
3negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)9.19518428
4cAMP biosynthetic process (GO:0006171)8.84331865
5negative regulation of alpha-beta T cell differentiation (GO:0046639)8.38588931
6enteric nervous system development (GO:0048484)8.03355056
7regulation of protein sumoylation (GO:0033233)7.57678827
8synaptic transmission, dopaminergic (GO:0001963)7.33959665
9* detection of chemical stimulus involved in sensory perception (GO:0050907)7.02606183
10righting reflex (GO:0060013)6.97602136
11positive regulation of mitochondrial fission (GO:0090141)6.97272145
12dendritic spine morphogenesis (GO:0060997)6.96733683
13heterotypic cell-cell adhesion (GO:0034113)6.60294499
14positive regulation of T-helper 1 type immune response (GO:0002827)6.43981849
15hepatocyte apoptotic process (GO:0097284)6.15600693
16arachidonic acid secretion (GO:0050482)6.09884057
17icosanoid secretion (GO:0032309)6.09884057
18endothelial cell differentiation (GO:0045446)6.01286634
19positive regulation of T-helper cell differentiation (GO:0045624)5.91517088
20phosphatidylinositol acyl-chain remodeling (GO:0036149)5.70755793
21drug transmembrane transport (GO:0006855)5.27999484
22phosphatidylserine acyl-chain remodeling (GO:0036150)5.26051914
23phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.17365259
24regulation of mitochondrial fission (GO:0090140)5.12971095
25icosanoid transport (GO:0071715)5.04371777
26fatty acid derivative transport (GO:1901571)5.04371777
27* detection of chemical stimulus (GO:0009593)5.02397201
28neuronal ion channel clustering (GO:0045161)5.01639697
29neural tube formation (GO:0001841)4.91021557
30negative regulation of alpha-beta T cell activation (GO:0046636)4.84593397
31hyaluronan catabolic process (GO:0030214)4.79410526
32chemosensory behavior (GO:0007635)4.75768716
33regulation of T-helper 1 type immune response (GO:0002825)4.62648390
34embryonic digestive tract morphogenesis (GO:0048557)4.54125764
35energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.52967522
36ATP hydrolysis coupled proton transport (GO:0015991)4.52967522
37positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.51973330
38cilium or flagellum-dependent cell motility (GO:0001539)4.46013256
39cyclic purine nucleotide metabolic process (GO:0052652)4.43394211
40nephron tubule morphogenesis (GO:0072078)4.36126744
41nephron epithelium morphogenesis (GO:0072088)4.36126744
42positive regulation of membrane potential (GO:0045838)4.33305414
43vocalization behavior (GO:0071625)4.31976133
44retina layer formation (GO:0010842)4.31060934
45cyclic nucleotide biosynthetic process (GO:0009190)4.30973487
46attachment of spindle microtubules to kinetochore (GO:0008608)4.29432870
47regulation of T-helper cell differentiation (GO:0045622)4.27804213
48negative regulation of actin filament bundle assembly (GO:0032232)4.23757023
49cellular response to glucagon stimulus (GO:0071377)4.18921465
50regulation of type 2 immune response (GO:0002828)4.17815631
51response to dietary excess (GO:0002021)4.17731639
52regulation of cAMP-mediated signaling (GO:0043949)4.13669747
53mitochondrial fusion (GO:0008053)4.11458932
54water transport (GO:0006833)4.08002090
55cAMP metabolic process (GO:0046058)4.01070423
56positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.96233816
57protein localization to synapse (GO:0035418)3.93548106
58dendritic spine organization (GO:0097061)3.92980964
59negative regulation of cytosolic calcium ion concentration (GO:0051481)3.90420113
60monoamine transport (GO:0015844)3.78274075
61cellular zinc ion homeostasis (GO:0006882)3.78261525
62cytoskeletal anchoring at plasma membrane (GO:0007016)3.72982587
63negative regulation of T cell differentiation (GO:0045581)3.71876248
64phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.69429091
65leukotriene biosynthetic process (GO:0019370)3.68008404
66fluid transport (GO:0042044)3.64194103
67drug transport (GO:0015893)3.61733131
68cellular response to ATP (GO:0071318)3.54365328
69positive regulation of protein targeting to membrane (GO:0090314)3.52517172
70sequestering of metal ion (GO:0051238)3.49173765
71positive regulation of alpha-beta T cell differentiation (GO:0046638)3.48095162
72pre-miRNA processing (GO:0031054)3.44514575
73sulfur amino acid catabolic process (GO:0000098)3.42247008
74regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.37726365
75negative regulation of homotypic cell-cell adhesion (GO:0034111)3.32269889
76positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.31797926
77left/right axis specification (GO:0070986)3.30483126
78negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.28622335
79neuromuscular process controlling posture (GO:0050884)3.26723798
80exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.23798450
81negative regulation of astrocyte differentiation (GO:0048712)3.19869519
82phosphatidylcholine acyl-chain remodeling (GO:0036151)3.19681610
83neurofilament cytoskeleton organization (GO:0060052)3.15705905
84prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.13270203
85renal tubule morphogenesis (GO:0061333)3.12351348
86response to glucagon (GO:0033762)3.11236532
87positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.10273316
88adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.08104398
89positive regulation of steroid hormone secretion (GO:2000833)3.08028402
90adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.06579952
91tooth mineralization (GO:0034505)14.4471889
92positive regulation of protein sumoylation (GO:0033235)11.9705267
93negative regulation of T-helper cell differentiation (GO:0045623)11.4482438
94negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)11.4482438
95* detection of chemical stimulus involved in sensory perception of smell (GO:0050911)11.3411452
96protein K11-linked deubiquitination (GO:0035871)10.5955912
97regulation of T-helper 1 cell differentiation (GO:0045625)10.3324204
98regulation of T-helper 2 cell differentiation (GO:0045628)10.2026605
99negative regulation of type 2 immune response (GO:0002829)10.1738970
100activation of protein kinase A activity (GO:0034199)10.0683920

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.65164515
2EGR1_19374776_ChIP-ChIP_THP-1_Human5.69182207
3IGF1R_20145208_ChIP-Seq_DFB_Human4.83383795
4AR_21572438_ChIP-Seq_LNCaP_Human4.82437255
5VDR_22108803_ChIP-Seq_LS180_Human4.24100194
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.61943693
7YY1_22570637_ChIP-Seq_MALME-3M_Human2.08787736
8TP53_16413492_ChIP-PET_HCT116_Human2.06527959
9PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.02223734
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse10.7763354
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89823656
12ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.89349129
13GATA1_19941826_ChIP-Seq_K562_Human1.86792917
14TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85695251
15POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.85695251
16DROSHA_22980978_ChIP-Seq_HELA_Human1.65314254
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62419233
18NR3C1_23031785_ChIP-Seq_PC12_Mouse1.61867032
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.59949345
20RNF2_27304074_Chip-Seq_ESCs_Mouse1.56640658
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.56158828
22EGR1_19032775_ChIP-ChIP_M12_Human1.52804630
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.52629872
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.43934100
25SMAD3_21741376_ChIP-Seq_HESCs_Human1.42547276
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.37473311
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35694447
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31904504
29SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31120091
30SMAD3_21741376_ChIP-Seq_EPCs_Human1.31070387
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28968134
32RNF2_27304074_Chip-Seq_NSC_Mouse1.24387513
33TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.22707326
34NANOG_18555785_Chip-Seq_ESCs_Mouse1.19881109
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15302608
36CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15061131
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14666868
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.14621978
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14345037
40EZH2_22144423_ChIP-Seq_EOC_Human1.13767844
41RXR_22108803_ChIP-Seq_LS180_Human1.13144279
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12423187
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12358000
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10939803
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.10322306
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.09262849
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08690910
48PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08339324
49HNFA_21074721_ChIP-Seq_CACO-2_Human1.07454921
50SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06132892
51GATA6_21074721_ChIP-Seq_CACO-2_Human1.04587060
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04304577
53SOX2_18555785_Chip-Seq_ESCs_Mouse1.02811823
54VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02526666
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01464408
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99484187
57NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99408861
58TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98956390
59PRDM14_20953172_ChIP-Seq_ESCs_Human0.98425979
60BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98194270
61ER_23166858_ChIP-Seq_MCF-7_Human0.96156210
62KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95398100
63CTCF_27219007_Chip-Seq_Bcells_Human0.94454746
64TBL1_22424771_ChIP-Seq_293T_Human0.94413607
65GBX2_23144817_ChIP-Seq_PC3_Human0.93826570
66CMYC_18555785_Chip-Seq_ESCs_Mouse0.93733831
67BCAT_22108803_ChIP-Seq_LS180_Human0.93213438
68ARNT_22903824_ChIP-Seq_MCF-7_Human0.92586164
69ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92329581
70PHF8_20622853_ChIP-Seq_HELA_Human0.92136291
71SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89380751
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88958530
73SMAD4_21741376_ChIP-Seq_HESCs_Human0.88283695
74TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87844689
75CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.87195039
76GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.86677707
77STAT3_23295773_ChIP-Seq_U87_Human0.86274919
78CJUN_26792858_Chip-Seq_BT549_Human0.85683165
79STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.84359871
80NANOG_16518401_ChIP-PET_MESCs_Mouse0.83862051
81TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.83100942
82SUZ12_18555785_Chip-Seq_ESCs_Mouse0.81910656
83RNF2_18974828_ChIP-Seq_MESCs_Mouse0.81813212
84EZH2_18974828_ChIP-Seq_MESCs_Mouse0.81813212
85PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.81684883
86NANOG_20526341_ChIP-Seq_ESCs_Human0.80783653
87NMYC_18555785_Chip-Seq_ESCs_Mouse0.80175907
88REST_21632747_ChIP-Seq_MESCs_Mouse0.79771171
89KLF4_18555785_Chip-Seq_ESCs_Mouse0.79580239
90GATA2_19941826_ChIP-Seq_K562_Human0.79395802
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.78769701
92E2F1_18555785_Chip-Seq_ESCs_Mouse0.78263089
93CTCF_21964334_ChIP-Seq_BJAB-B_Human0.77391793
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76754376
95RING1B_27294783_Chip-Seq_ESCs_Mouse0.76747583
96GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.76311105
97ZNF274_21170338_ChIP-Seq_K562_Hela0.74807556
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.74056656
99REST_18959480_ChIP-ChIP_MESCs_Mouse0.72839546
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.72764929

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism9.70426664
2MP0004130_abnormal_muscle_cell5.11911829
3MP0004264_abnormal_extraembryonic_tissu4.00759065
4MP0003252_abnormal_bile_duct3.58384894
5MP0004133_heterotaxia2.80418773
6MP0002928_abnormal_bile_duct2.70760644
7MP0006072_abnormal_retinal_apoptosis2.46303238
8MP0005448_abnormal_energy_balance2.33583808
9MP0005408_hypopigmentation2.20717852
10MP0002751_abnormal_autonomic_nervous2.18444102
11MP0001270_distended_abdomen2.12642451
12MP0004272_abnormal_basement_membrane2.07517153
13MP0003329_amyloid_beta_deposits2.03776877
14MP0005084_abnormal_gallbladder_morpholo12.5995561
15MP0003943_abnormal_hepatobiliary_system1.82062269
16MP0005220_abnormal_exocrine_pancreas1.65324447
17MP0005165_increased_susceptibility_to1.65006181
18MP0005379_endocrine/exocrine_gland_phen1.59615780
19MP0009764_decreased_sensitivity_to1.43497772
20MP0001958_emphysema1.36463800
21MP0003718_maternal_effect1.31942099
22MP0000604_amyloidosis1.28206793
23MP0001529_abnormal_vocalization1.26690400
24MP0002909_abnormal_adrenal_gland1.20372968
25MP0001905_abnormal_dopamine_level1.06844023
26MP0005646_abnormal_pituitary_gland1.05835019
27MP0000470_abnormal_stomach_morphology1.01344623
28MP0002572_abnormal_emotion/affect_behav0.98815580
29MP0000465_gastrointestinal_hemorrhage0.98230763
30MP0003638_abnormal_response/metabolism_0.97228693
31MP0001944_abnormal_pancreas_morphology0.92133209
32MP0008569_lethality_at_weaning0.92051430
33MP0001851_eye_inflammation0.89599213
34MP0003121_genomic_imprinting0.86376294
35MP0005164_abnormal_response_to0.85143269
36MP0002405_respiratory_system_inflammati0.84058725
37MP0004019_abnormal_vitamin_homeostasis0.82026240
38MP0008469_abnormal_protein_level0.81844734
39MP0001790_abnormal_immune_system0.77971868
40MP0005387_immune_system_phenotype0.77971868
41MP0000371_diluted_coat_color0.77806970
42MP0001800_abnormal_humoral_immune0.77665430
43MP0001915_intracranial_hemorrhage0.76796219
44MP0001533_abnormal_skeleton_physiology0.72198230
45MP0002693_abnormal_pancreas_physiology0.71036660
46MP0003866_abnormal_defecation0.69845034
47MP0000609_abnormal_liver_physiology0.69723331
48MP0002098_abnormal_vibrissa_morphology0.67725516
49MP0002136_abnormal_kidney_physiology0.65614325
50MP0000703_abnormal_thymus_morphology0.64444035
51MP0002078_abnormal_glucose_homeostasis0.63071592
52MP0003953_abnormal_hormone_level0.63027659
53MP0008875_abnormal_xenobiotic_pharmacok0.61368296
54MP0005253_abnormal_eye_physiology0.60547744
55MP0001845_abnormal_inflammatory_respons0.55763922
56MP0004947_skin_inflammation0.54524420
57MP0003195_calcinosis0.53808766
58MP0002722_abnormal_immune_system0.52588989
59MP0002419_abnormal_innate_immunity0.49809560
60MP0009642_abnormal_blood_homeostasis0.47549946
61MP0002998_abnormal_bone_remodeling0.46167907
62MP0005551_abnormal_eye_electrophysiolog0.45190875
63MP0002429_abnormal_blood_cell0.42460103
64MP0004484_altered_response_of0.41333779
65MP0003303_peritoneal_inflammation0.41029218
66MP0002822_catalepsy0.40501645
67MP0000759_abnormal_skeletal_muscle0.39790451
68MP0002452_abnormal_antigen_presenting0.38032416
69MP0001501_abnormal_sleep_pattern0.37899978
70MP0002420_abnormal_adaptive_immunity0.37629926
71MP0005390_skeleton_phenotype0.37476458
72MP0005360_urolithiasis0.37273527
73MP0000477_abnormal_intestine_morphology0.37253062
74MP0005334_abnormal_fat_pad0.37187238
75MP0001819_abnormal_immune_cell0.37012495
76MP0000716_abnormal_immune_system0.35391445
77MP0002398_abnormal_bone_marrow0.35215851
78MP0009931_abnormal_skin_appearance0.35102795
79MP0000598_abnormal_liver_morphology0.34562657
80MP0005395_other_phenotype0.32645770
81MP0002723_abnormal_immune_serum0.32051040
82MP0000920_abnormal_myelination0.31476405
83MP0001986_abnormal_taste_sensitivity0.31143182
84MP0002882_abnormal_neuron_morphology0.29959460
85MP0002229_neurodegeneration0.29127059
86MP0005332_abnormal_amino_acid0.28325482
87MP0008004_abnormal_stomach_pH0.27561556
88MP0003315_abnormal_perineum_morphology0.27421288
89MP0005423_abnormal_somatic_nervous0.26802853
90MP0001299_abnormal_eye_distance/0.26374605
91MP0000639_abnormal_adrenal_gland0.26260528
92MP0000689_abnormal_spleen_morphology0.26239976
93MP0001175_abnormal_lung_morphology0.25661245
94MP0005365_abnormal_bile_salt0.24641319
95MP0005193_abnormal_anterior_eye0.24541673
96MP0009053_abnormal_anal_canal0.24469629
97MP0008932_abnormal_embryonic_tissue0.23891015
98MP0000372_irregular_coat_pigmentation0.23533229
99MP0006276_abnormal_autonomic_nervous0.23472981
100MP0005000_abnormal_immune_tolerance0.23362934

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of calcium-phosphate metabolism (HP:0100530)9.92107279
2Abnormality of renal resorption (HP:0011038)8.10477401
3Abnormality of dental color (HP:0011073)8.08296475
4Osteomalacia (HP:0002749)8.01205769
5Polyuria (HP:0000103)7.65686522
6Abnormality of the dental pulp (HP:0006479)7.35755005
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.83471773
8Abnormal urine output (HP:0012590)6.54247816
9Abnormality of renal excretion (HP:0011036)5.70586714
10Round ear (HP:0100830)5.50064426
11Chronic bronchitis (HP:0004469)4.96756728
12Volvulus (HP:0002580)4.42026968
13IgM deficiency (HP:0002850)4.22479218
14Lip pit (HP:0100267)4.12096149
15Abnormality of midbrain morphology (HP:0002418)4.03984978
16Molar tooth sign on MRI (HP:0002419)4.03984978
17Nephrocalcinosis (HP:0000121)3.95547203
18Autoimmune thrombocytopenia (HP:0001973)3.94067340
19Toxemia of pregnancy (HP:0100603)3.93430278
20Esophageal varix (HP:0002040)3.65700911
21Panhypogammaglobulinemia (HP:0003139)3.56440821
22Lipoatrophy (HP:0100578)3.48013153
23Depressed nasal tip (HP:0000437)3.43669990
24Rhinitis (HP:0012384)3.29109512
25Sparse lateral eyebrow (HP:0005338)3.26782486
26Abnormal respiratory motile cilium physiology (HP:0012261)3.26699402
27Tachypnea (HP:0002789)3.25099334
28Large earlobe (HP:0009748)3.20443549
29Intestinal fistula (HP:0100819)3.07733525
30Hyperphosphaturia (HP:0003109)2.98503231
31Hypoparathyroidism (HP:0000829)2.96174707
32Drooling (HP:0002307)2.93924002
33Agammaglobulinemia (HP:0004432)2.92821347
34Thick eyebrow (HP:0000574)2.89840904
35Chronic mucocutaneous candidiasis (HP:0002728)2.87175239
36Recurrent cutaneous fungal infections (HP:0011370)2.87175239
37Excessive salivation (HP:0003781)2.82122274
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.80269234
39Nephronophthisis (HP:0000090)2.78310088
40Personality changes (HP:0000751)2.69406798
41Colitis (HP:0002583)2.63364442
42Hepatitis (HP:0012115)2.59593737
43Glycosuria (HP:0003076)2.53715578
44Abnormality of urine glucose concentration (HP:0011016)2.53715578
45Dilated cardiomyopathy (HP:0001644)2.53369229
46Abnormal urine phosphate concentration (HP:0012599)2.51252919
47Ureteral stenosis (HP:0000071)2.50516465
48Petechiae (HP:0000967)2.47435324
49Abnormality of transition element cation homeostasis (HP:0011030)2.42855630
50Abnormality of the fingertips (HP:0001211)2.39841271
51Striae distensae (HP:0001065)2.39176522
52Short 5th finger (HP:0009237)2.38603219
53Ureteral obstruction (HP:0006000)2.31456128
54Gingival overgrowth (HP:0000212)2.30591120
55Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.27910479
56Inability to walk (HP:0002540)2.27793708
57Sudden cardiac death (HP:0001645)2.26288563
58Nephropathy (HP:0000112)2.26216104
59Hypercalciuria (HP:0002150)2.24822961
60Decreased muscle mass (HP:0003199)2.11736198
61Recurrent otitis media (HP:0000403)2.08300836
62Abnormality of the renal medulla (HP:0100957)2.05718190
63Bronchitis (HP:0012387)2.05167458
64Preauricular pit (HP:0004467)2.04469711
65Periauricular skin pits (HP:0100277)2.04469711
66Overgrowth (HP:0001548)12.0246016
67Amelogenesis imperfecta (HP:0000705)11.5897623
68Prominent supraorbital ridges (HP:0000336)1.96785797
69Villous atrophy (HP:0011473)1.92672292
70Abnormality of small intestinal villus morphology (HP:0011472)1.92672292
71Chondrocalcinosis (HP:0000934)1.92601534
72Abnormality of Sharpey fibers (HP:0100685)1.87564533
73Abnormality of salivation (HP:0100755)1.86617770
74Truncal ataxia (HP:0002078)1.84945692
75Stage 5 chronic kidney disease (HP:0003774)1.83848895
76Anal stenosis (HP:0002025)1.83795420
77Chorioretinal coloboma (HP:0000567)1.83277979
78Delayed eruption of teeth (HP:0000684)1.82190991
79Ectopic kidney (HP:0000086)1.81431221
80Renal tubular dysfunction (HP:0000124)1.78742898
81Preauricular skin tag (HP:0000384)1.78288172
82Small hand (HP:0200055)1.76639451
83Viral hepatitis (HP:0006562)1.75004322
84Inflammation of the large intestine (HP:0002037)1.70315483
85Limited elbow extension (HP:0001377)1.69161121
86Mask-like facies (HP:0000298)1.59877936
87Oculomotor apraxia (HP:0000657)1.58783594
88Palmoplantar keratoderma (HP:0000982)1.57145173
89Polyneuropathy (HP:0001271)1.55499382
90Gastrointestinal inflammation (HP:0004386)1.54397785
91Blepharitis (HP:0000498)1.53070677
92Torticollis (HP:0000473)1.49685991
93Skin tags (HP:0010609)1.49366851
94Ectropion (HP:0000656)1.46714678
95Bronchiectasis (HP:0002110)1.46442166
96Prenatal maternal abnormality (HP:0002686)1.44680760
97Highly arched eyebrow (HP:0002553)1.42828166
98Osteoarthritis (HP:0002758)1.39507346
99Skin pits (HP:0100276)1.34336850
100Aplasia/Hypoplasia of the earlobes (HP:0009906)1.31377723

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.61722002
2BLK4.38583206
3STK34.03553312
4RIPK43.17388873
5CDC42BPA2.20220729
6BMPR22.09461160
7NTRK214.1768216
8HIPK21.21612553
9FGFR10.84744338
10ROCK20.78199100
11VRK20.72709708
12SYK0.71668748
13INSRR0.60714625
14SRC0.60523934
15OBSCN0.59794830
16PRKAA10.59479735
17GRK10.59086347
18PRKCQ0.56579008
19ROCK10.55920415
20MUSK0.53884073
21TIE10.47452071
22MAP4K20.47434757
23ADRBK20.44989040
24GRK70.44656049
25MAPK150.44320405
26PRKACG0.43498146
27DDR20.43330904
28WNK30.40402880
29ABL10.39931941
30MAPKAPK50.39618740
31TXK0.37784284
32PRKACA0.36753111
33GRK60.34167039
34PIK3CG0.33895929
35VRK10.33763250
36PRKACB0.33493246
37PLK10.33249735
38CAMK2A0.29965814
39SRPK10.29933690
40KDR0.28558295
41PIM20.25817427
42MAPK40.24818838
43GRK50.24761754
44ERBB40.24741006
45LYN0.24041941
46PLK40.23192675
47MAPK140.22244649
48PRKCA0.21908902
49GSK3B0.21106468
50PRKCB0.20430229
51MATK0.19880265
52KIT0.18875003
53RPS6KA30.17771623
54OXSR10.15837435
55EPHA40.15722978
56PASK0.15355935
57TEC0.15184295
58IRAK40.15102761
59CDK10.14672564
60PRKCD0.13901688
61ABL20.13040902
62TTN0.12210527
63ITK0.11951204
64PIM10.11925316
65LMTK20.11857646
66ZAK0.11663852
67ADRBK10.10982875
68MST1R0.10981203
69FYN0.10735727
70BMPR1B0.10650794
71PRKCG0.10560023
72CSNK1A10.10469152
73EPHA20.10270385
74PRKDC0.10211470
75DAPK30.09765028
76PHKG20.08780396
77PHKG10.08780396
78TNK20.08439334
79HCK0.08184147
80TAOK20.08091670
81CAMK2G0.07339198
82CHUK0.07185171
83STK390.07160332
84MAPK90.06916063
85AKT10.06716433
86LCK0.06712766
87FLT30.06527675
88MAP2K60.06363553
89TLK10.05913796
90WNK40.05877935
91RPS6KA50.05832659
92MAPK130.05552544
93ERN10.05058315
94CAMK2B0.04377058
95BTK0.04149350
96EGFR0.03939468
97PKN10.03229154
98IGF1R0.03114609
99PIK3CA0.02667288
100CDK80.01853286

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.27414941
2Sulfur relay system_Homo sapiens_hsa041223.93118688
3Sulfur metabolism_Homo sapiens_hsa009203.71263556
4Ovarian steroidogenesis_Homo sapiens_hsa049133.36210755
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.20776351
6Linoleic acid metabolism_Homo sapiens_hsa005912.95400144
7Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.85402678
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.69359345
9Collecting duct acid secretion_Homo sapiens_hsa049662.50233724
10Bile secretion_Homo sapiens_hsa049762.37283715
11Vibrio cholerae infection_Homo sapiens_hsa051102.37106902
12Pancreatic secretion_Homo sapiens_hsa049722.23150843
13Thyroid hormone synthesis_Homo sapiens_hsa049182.21008161
14Salivary secretion_Homo sapiens_hsa049702.12942808
15Fat digestion and absorption_Homo sapiens_hsa049752.10645260
16Gastric acid secretion_Homo sapiens_hsa049712.07116365
17Synaptic vesicle cycle_Homo sapiens_hsa047212.04296960
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.01383636
19Cocaine addiction_Homo sapiens_hsa050301.94343643
20Circadian entrainment_Homo sapiens_hsa047131.81771856
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81132787
22Insulin secretion_Homo sapiens_hsa049111.77120620
23Vascular smooth muscle contraction_Homo sapiens_hsa042701.71762631
24Taste transduction_Homo sapiens_hsa047421.71292165
25Glutamatergic synapse_Homo sapiens_hsa047241.69713068
26Morphine addiction_Homo sapiens_hsa050321.66740142
27Longevity regulating pathway - mammal_Homo sapiens_hsa042111.65952310
28Dilated cardiomyopathy_Homo sapiens_hsa054141.63820909
29GABAergic synapse_Homo sapiens_hsa047271.63602683
30Ether lipid metabolism_Homo sapiens_hsa005651.61592756
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55262926
32Gap junction_Homo sapiens_hsa045401.48295377
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.40868004
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.37631285
35Amphetamine addiction_Homo sapiens_hsa050311.35912625
36Arachidonic acid metabolism_Homo sapiens_hsa005901.34740680
37GnRH signaling pathway_Homo sapiens_hsa049121.31699527
38Melanogenesis_Homo sapiens_hsa049161.27461192
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.20810695
40Oxytocin signaling pathway_Homo sapiens_hsa049211.15574984
41Platelet activation_Homo sapiens_hsa046111.14872501
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12597937
43Cholinergic synapse_Homo sapiens_hsa047251.11089677
44Calcium signaling pathway_Homo sapiens_hsa040201.06197365
45Estrogen signaling pathway_Homo sapiens_hsa049151.01786766
46Circadian rhythm_Homo sapiens_hsa047100.91205104
47Dorso-ventral axis formation_Homo sapiens_hsa043200.79164903
48Serotonergic synapse_Homo sapiens_hsa047260.75801498
49Pyruvate metabolism_Homo sapiens_hsa006200.73179870
50ECM-receptor interaction_Homo sapiens_hsa045120.69477950
51Rheumatoid arthritis_Homo sapiens_hsa053230.68536313
52Oocyte meiosis_Homo sapiens_hsa041140.68352011
53Chemokine signaling pathway_Homo sapiens_hsa040620.65150340
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62779913
55Primary immunodeficiency_Homo sapiens_hsa053400.61642582
56Parkinsons disease_Homo sapiens_hsa050120.59196835
57RNA degradation_Homo sapiens_hsa030180.56486383
58Oxidative phosphorylation_Homo sapiens_hsa001900.46573591
59cAMP signaling pathway_Homo sapiens_hsa040240.46218018
60Alcoholism_Homo sapiens_hsa050340.41563130
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39634564
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38802886
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.37218027
64Staphylococcus aureus infection_Homo sapiens_hsa051500.36830093
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.33935489
66Purine metabolism_Homo sapiens_hsa002300.33672935
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31437841
68Dopaminergic synapse_Homo sapiens_hsa047280.31042142
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.23501790
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.23183325
71Systemic lupus erythematosus_Homo sapiens_hsa053220.23068686
72Retinol metabolism_Homo sapiens_hsa008300.23059787
73Prion diseases_Homo sapiens_hsa050200.22416158
74African trypanosomiasis_Homo sapiens_hsa051430.20685078
75Rap1 signaling pathway_Homo sapiens_hsa040150.17876271
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17339422
77Tuberculosis_Homo sapiens_hsa051520.17253342
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.17096024
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15212241
80Phagosome_Homo sapiens_hsa041450.14873804
81Glucagon signaling pathway_Homo sapiens_hsa049220.13386103
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.12087572
83Type I diabetes mellitus_Homo sapiens_hsa049400.11128564
84Hedgehog signaling pathway_Homo sapiens_hsa043400.11089000
85Leishmaniasis_Homo sapiens_hsa051400.10908041
86Caffeine metabolism_Homo sapiens_hsa002320.09281296
87Asthma_Homo sapiens_hsa053100.09005196
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.08998061
89Ras signaling pathway_Homo sapiens_hsa040140.08707765
90HTLV-I infection_Homo sapiens_hsa051660.08177964
91Chemical carcinogenesis_Homo sapiens_hsa052040.07482597
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.06646404
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.05084102
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.04086771
95Malaria_Homo sapiens_hsa051440.02645900
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.02213690
97Hematopoietic cell lineage_Homo sapiens_hsa046400.01829303
98Nicotine addiction_Homo sapiens_hsa050330.00242949
99Renin secretion_Homo sapiens_hsa04924-0.0069246
100Antigen processing and presentation_Homo sapiens_hsa04612-0.0041692

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »