ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cellular response to cadmium ion (GO:0071276)	9.87618860
2	monoubiquitinated protein deubiquitination (GO:0035520)	6.13241885
3	cytoplasmic mRNA processing body assembly (GO:0033962)	6.04038391
4	regulation of hippo signaling (GO:0035330)	5.63827969
5	regulation of posttranscriptional gene silencing (GO:0060147)	5.50510661
6	regulation of gene silencing by miRNA (GO:0060964)	5.50510661
7	regulation of gene silencing by RNA (GO:0060966)	5.50510661
8	negative regulation of neurotransmitter secretion (GO:0046929)	5.45733574
9	mesenchymal-epithelial cell signaling (GO:0060638)	5.45692678
10	branching involved in labyrinthine layer morphogenesis (GO:0060670)	5.30763950
11	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	5.27363362
12	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	5.27026837
13	negative regulation of B cell apoptotic process (GO:0002903)	4.89820972
14	negative regulation of lipase activity (GO:0060192)	4.82310769
15	UDP-N-acetylglucosamine metabolic process (GO:0006047)	4.71596189
16	attachment of spindle microtubules to kinetochore (GO:0008608)	4.66111465
17	positive regulation of vasculogenesis (GO:2001214)	4.61512125
18	negative regulation of fatty acid transport (GO:2000192)	4.60362811
19	response to cadmium ion (GO:0046686)	4.57455101
20	homocysteine metabolic process (GO:0050667)	4.45465397
21	protein-cofactor linkage (GO:0018065)	4.31612173
22	COPII vesicle coating (GO:0048208)	4.29015492
23	G-protein coupled receptor internalization (GO:0002031)	4.21588270
24	regulation of cholesterol homeostasis (GO:2000188)	4.20086259
25	linoleic acid metabolic process (GO:0043651)	4.10028231
26	negative regulation of neurotransmitter transport (GO:0051589)	4.07250224
27	response to zinc ion (GO:0010043)	4.04227657
28	zinc ion homeostasis (GO:0055069)	3.92878937
29	response to redox state (GO:0051775)	3.89568016
30	resolution of meiotic recombination intermediates (GO:0000712)	3.88474288
31	positive regulation of sodium ion transmembrane transport (GO:1902307)	3.87886978
32	cellular zinc ion homeostasis (GO:0006882)	3.87503936
33	negative regulation of endothelial cell apoptotic process (GO:2000352)	3.86763944
34	nucleotide-sugar biosynthetic process (GO:0009226)	3.81053097
35	embryonic viscerocranium morphogenesis (GO:0048703)	3.79701913
36	cell fate commitment involved in formation of primary germ layer (GO:0060795)	3.79470551
37	lung vasculature development (GO:0060426)	3.77010181
38	regulation of B cell apoptotic process (GO:0002902)	3.56718962
39	regulation of apoptotic process involved in morphogenesis (GO:1902337)	3.56439518
40	regulation of prostaglandin secretion (GO:0032306)	3.56260053
41	negative regulation of axon extension involved in axon guidance (GO:0048843)	3.55507969
42	regulation of vasculogenesis (GO:2001212)	3.53838834
43	lung epithelium development (GO:0060428)	3.44233892
44	ER overload response (GO:0006983)	3.41444262
45	epithelial cell differentiation involved in kidney development (GO:0035850)	3.39011588
46	cysteine metabolic process (GO:0006534)	3.38829314
47	snRNA transcription (GO:0009301)	3.38327391
48	DNA damage induced protein phosphorylation (GO:0006975)	3.35840398
49	negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)	3.34333947
50	embryonic process involved in female pregnancy (GO:0060136)	3.33853645
51	DNA topological change (GO:0006265)	3.32452127
52	microtubule anchoring (GO:0034453)	3.24195153
53	DNA replication checkpoint (GO:0000076)	3.17074606
54	DNA replication initiation (GO:0006270)	3.13875306
55	regulation of cell migration involved in sprouting angiogenesis (GO:0090049)	3.11315834
56	triglyceride homeostasis (GO:0070328)	3.10160920
57	acylglycerol homeostasis (GO:0055090)	3.10160920
58	anterior/posterior axis specification, embryo (GO:0008595)	3.09837209
59	regulation of gene silencing (GO:0060968)	3.01188927
60	intra-S DNA damage checkpoint (GO:0031573)	2.99603853
61	positive regulation of lipid storage (GO:0010884)	2.98144413
62	regulation of centriole replication (GO:0046599)	2.93611802
63	negative regulation of fatty acid biosynthetic process (GO:0045717)	2.92974487
64	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.90588149
65	synapsis (GO:0007129)	2.89470077
66	C21-steroid hormone biosynthetic process (GO:0006700)	2.88805895
67	positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:0061081	2.86860758
68	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	2.86747769
69	negative regulation of mast cell activation (GO:0033004)	2.83119827
70	microtubule nucleation (GO:0007020)	2.81800133
71	lymphangiogenesis (GO:0001946)	2.80911886
72	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	2.80191648
73	prenylation (GO:0097354)	2.78815011
74	protein prenylation (GO:0018342)	2.78815011
75	endothelium development (GO:0003158)	2.78671238
76	positive regulation of tolerance induction (GO:0002645)	2.77010273
77	zinc ion transmembrane transport (GO:0071577)	2.76715605
78	sister chromatid segregation (GO:0000819)	2.76534616
79	diterpenoid biosynthetic process (GO:0016102)	2.74598546
80	nuclear pore complex assembly (GO:0051292)	2.74538750
81	phenol-containing compound catabolic process (GO:0019336)	2.72793909
82	branching involved in salivary gland morphogenesis (GO:0060445)	2.70346883
83	progesterone metabolic process (GO:0042448)	2.70188222
84	skin morphogenesis (GO:0043589)	2.67080925
85	regulation of interleukin-8 biosynthetic process (GO:0045414)	2.65572116
86	long-chain fatty acid transport (GO:0015909)	2.65174967
87	alanine transport (GO:0032328)	2.64397314
88	regulation of endothelial cell apoptotic process (GO:2000351)	2.64218951
89	nucleobase-containing small molecule interconversion (GO:0015949)	2.64019144
90	fatty acid transport (GO:0015908)	2.61363806
91	recombinational repair (GO:0000725)	2.60976871
92	forebrain neuron development (GO:0021884)	2.60259504
93	negative regulation of vascular permeability (GO:0043116)	2.60057107
94	negative regulation of macrophage differentiation (GO:0045650)	2.59014744
95	mitotic sister chromatid segregation (GO:0000070)	2.58377967
96	face development (GO:0060324)	2.58372174
97	double-strand break repair via homologous recombination (GO:0000724)	2.55935318
98	neuronal ion channel clustering (GO:0045161)	2.55562898
99	nuclear pore organization (GO:0006999)	2.55010028
100	cellular response to zinc ion (GO:0071294)	12.2081392

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	9.49137252
2	E2F7_22180533_ChIP-Seq_HELA_Human	6.37964513
3	HIF1A_21447827_ChIP-Seq_MCF-7_Human	4.77281526
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.79492162
5	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	3.12592531
6	AR_21572438_ChIP-Seq_LNCaP_Human	3.07291288
7	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.76615717
8	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.75891727
9	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.57588075
10	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.57588075
11	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.57588075
12	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.46266469
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.32738046
14	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.25952996
15	VDR_22108803_ChIP-Seq_LS180_Human	2.15701629
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.14574863
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.11155085
18	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.91125893
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.87887334
20	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.76646766
21	AR_21909140_ChIP-Seq_LNCAP_Human	1.72578717
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.68305097
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.58512590
24	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.56482197
25	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.48431767
26	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.46224913
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.44022939
28	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.41465423
29	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.40068658
30	EWS_26573619_Chip-Seq_HEK293_Human	1.39349871
31	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.36301374
32	HOXB7_26014856_ChIP-Seq_BT474_Human	1.35764184
33	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.34661702
34	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.34016973
35	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.33919632
36	DCP1A_22483619_ChIP-Seq_HELA_Human	1.31948034
37	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.28567781
38	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.22393922
39	FUS_26573619_Chip-Seq_HEK293_Human	1.22257350
40	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.17853468
41	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.17138687
42	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	1.15500080
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.14315629
44	BRD4_25478319_ChIP-Seq_HGPS_Human	1.09940178
45	STAT3_23295773_ChIP-Seq_U87_Human	1.08572067
46	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.08149798
47	NCOR1_26117541_ChIP-Seq_K562_Human	1.06900144
48	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.06533498
49	MYC_18940864_ChIP-ChIP_HL60_Human	1.06345434
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.05423704
51	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.04039677
52	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03886401
53	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01918086
54	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.00994900
55	GATA1_19941826_ChIP-Seq_K562_Human	0.99293721
56	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.98139122
57	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.95476194
58	EGR1_19374776_ChIP-ChIP_THP-1_Human	0.94865101
59	GBX2_23144817_ChIP-Seq_PC3_Human	0.94169691
60	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.93908741
61	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.93770377
62	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.92370481
63	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.92361042
64	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.90134458
65	P300_19829295_ChIP-Seq_ESCs_Human	0.89566452
66	ETV1_20927104_ChIP-Seq_GIST48_Human	0.88862189
67	SMAD4_21799915_ChIP-Seq_A2780_Human	0.88663125
68	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.84734478
69	NFYB_21822215_ChIP-Seq_K562_Human	0.84063561
70	NANOG_19829295_ChIP-Seq_ESCs_Human	0.83992311
71	SOX2_19829295_ChIP-Seq_ESCs_Human	0.83992311
72	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.83534542
73	CHD1_26751641_Chip-Seq_LNCaP_Human	0.83353137
74	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.83242037
75	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.82148778
76	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.81872644
77	PHF8_20622853_ChIP-Seq_HELA_Human	0.81721666
78	TBL1_22424771_ChIP-Seq_293T_Human	0.80919247
79	IRF1_19129219_ChIP-ChIP_H3396_Human	0.80672028
80	CJUN_26792858_Chip-Seq_BT549_Human	0.80469063
81	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.80009608
82	VDR_23849224_ChIP-Seq_CD4+_Human	0.79222990
83	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.78984388
84	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.78599493
85	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.77843775
86	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.76191345
87	TCF4_23295773_ChIP-Seq_U87_Human	0.75308055
88	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.74784973
89	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.74577218
90	RXR_22108803_ChIP-Seq_LS180_Human	0.73922280
91	RBPJ_21746931_ChIP-Seq_IB4_Human	0.73664047
92	SOX9_26525672_Chip-Seq_HEART_Mouse	0.73064078
93	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.72456150
94	RUNX2_22187159_ChIP-Seq_PCA_Human	0.72190067
95	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.71742494
96	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.71712165
97	TP53_16413492_ChIP-PET_HCT116_Human	0.71280608
98	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.71183238
99	TP53_22573176_ChIP-Seq_HFKS_Human	0.70893688
100	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.70705014

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003950_abnormal_plasma_membrane	8.93996729
2	MP0003011_delayed_dark_adaptation	7.57871518
3	MP0008438_abnormal_cutaneous_collagen	3.69850817
4	MP0002254_reproductive_system_inflammat	3.23135489
5	MP0008057_abnormal_DNA_replication	2.91448343
6	MP0004233_abnormal_muscle_weight	2.83212727
7	MP0001879_abnormal_lymphatic_vessel	2.81027895
8	MP0003186_abnormal_redox_activity	2.44609903
9	MP0004019_abnormal_vitamin_homeostasis	2.18334079
10	MP0002295_abnormal_pulmonary_circulatio	2.18328118
11	MP0004147_increased_porphyrin_level	2.16281812
12	MP0005275_abnormal_skin_tensile	2.12600866
13	MP0010368_abnormal_lymphatic_system	2.01608407
14	MP0009697_abnormal_copulation	1.99647898
15	MP0005666_abnormal_adipose_tissue	1.87598392
16	MP0000427_abnormal_hair_cycle	1.73415836
17	MP0009278_abnormal_bone_marrow	1.58953759
18	MP0003786_premature_aging	1.58679365
19	MP0001764_abnormal_homeostasis	1.54770096
20	MP0003656_abnormal_erythrocyte_physiolo	1.48594682
21	MP0002876_abnormal_thyroid_physiology	1.46166785
22	MP0008058_abnormal_DNA_repair	1.44454505
23	MP0001502_abnormal_circadian_rhythm	1.40867407
24	MP0003693_abnormal_embryo_hatching	1.37577394
25	MP0010030_abnormal_orbit_morphology	1.33711586
26	MP0003646_muscle_fatigue	1.32907219
27	MP0001177_atelectasis	1.30195659
28	MP0001727_abnormal_embryo_implantation	1.28357485
29	MP0003221_abnormal_cardiomyocyte_apopto	1.25649044
30	MP0003718_maternal_effect	1.23421221
31	MP0005360_urolithiasis	1.21714244
32	MP0001545_abnormal_hematopoietic_system	1.19954980
33	MP0005397_hematopoietic_system_phenotyp	1.19954980
34	MP0003111_abnormal_nucleus_morphology	1.17376819
35	MP0005551_abnormal_eye_electrophysiolog	1.17020907
36	MP0005076_abnormal_cell_differentiation	1.10647641
37	MP0008995_early_reproductive_senescence	1.08401063
38	MP0010094_abnormal_chromosome_stability	1.08393671
39	MP0001881_abnormal_mammary_gland	1.04763320
40	MP0010329_abnormal_lipoprotein_level	1.01996228
41	MP0005083_abnormal_biliary_tract	1.01947535
42	MP0008932_abnormal_embryonic_tissue	1.01559759
43	MP0002138_abnormal_hepatobiliary_system	1.00981612
44	MP0005253_abnormal_eye_physiology	0.98898198
45	MP0005375_adipose_tissue_phenotype	0.98247807
46	MP0001501_abnormal_sleep_pattern	0.97610441
47	MP0000613_abnormal_salivary_gland	0.97461373
48	MP0004043_abnormal_pH_regulation	0.97012594
49	MP0004957_abnormal_blastocyst_morpholog	0.95513938
50	MP0003942_abnormal_urinary_system	0.94944222
51	MP0009384_cardiac_valve_regurgitation	0.92471711
52	MP0002160_abnormal_reproductive_system	0.92114437
53	MP0010234_abnormal_vibrissa_follicle	0.91018804
54	MP0003828_pulmonary_edema	0.89595521
55	MP0005389_reproductive_system_phenotype	0.89284387
56	MP0001929_abnormal_gametogenesis	0.87342673
57	MP0005623_abnormal_meninges_morphology	0.85461993
58	MP0003699_abnormal_female_reproductive	0.84187865
59	MP0001299_abnormal_eye_distance/	0.83774882
60	MP0000383_abnormal_hair_follicle	0.81581062
61	MP0004272_abnormal_basement_membrane	0.80977826
62	MP0002210_abnormal_sex_determination	0.80289949
63	MP0001119_abnormal_female_reproductive	0.80176922
64	MP0003279_aneurysm	0.80033986
65	MP0005410_abnormal_fertilization	0.79589302
66	MP0002735_abnormal_chemical_nociception	0.77800251
67	MP0010678_abnormal_skin_adnexa	0.77385462
68	MP0010307_abnormal_tumor_latency	0.77038539
69	MP0002736_abnormal_nociception_after	0.76951493
70	MP0002282_abnormal_trachea_morphology	0.76313781
71	MP0000653_abnormal_sex_gland	0.75071137
72	MP0005409_darkened_coat_color	0.73895479
73	MP0003936_abnormal_reproductive_system	0.73063828
74	MP0008775_abnormal_heart_ventricle	0.73038274
75	MP0001784_abnormal_fluid_regulation	0.67492605
76	MP0001968_abnormal_touch/_nociception	0.66147919
77	MP0003698_abnormal_male_reproductive	0.66103347
78	MP0005167_abnormal_blood-brain_barrier	0.65113877
79	MP0000377_abnormal_hair_follicle	0.65026731
80	MP0001919_abnormal_reproductive_system	0.62817369
81	MP0003937_abnormal_limbs/digits/tail_de	0.62605914
82	MP0003091_abnormal_cell_migration	0.62236451
83	MP0005452_abnormal_adipose_tissue	0.60177105
84	MP0005334_abnormal_fat_pad	0.60091596
85	MP0000350_abnormal_cell_proliferation	0.59876894
86	MP0002970_abnormal_white_adipose	0.59700130
87	MP0001145_abnormal_male_reproductive	0.59138957
88	MP0009763_increased_sensitivity_to	0.58929482
89	MP0000467_abnormal_esophagus_morphology	0.58536295
90	MP0000313_abnormal_cell_death	0.58455948
91	MP0005391_vision/eye_phenotype	0.58425647
92	MP0005376_homeostasis/metabolism_phenot	0.58415945
93	MP0005647_abnormal_sex_gland	0.57757181
94	MP0006054_spinal_hemorrhage	0.57533888
95	MP0000631_abnormal_neuroendocrine_gland	0.57167367
96	MP0005386_behavior/neurological_phenoty	0.56920096
97	MP0004924_abnormal_behavior	0.56920096
98	MP0000372_irregular_coat_pigmentation	0.56348628
99	MP0005164_abnormal_response_to	0.56270408
100	MP0003959_abnormal_lean_body	0.55291293

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased serum pyruvate (HP:0003542)	5.65145562
2	Abnormality of glycolysis (HP:0004366)	4.71029246
3	Increased number of teeth (HP:0011069)	4.47779441
4	Short middle phalanx of the 5th finger (HP:0004220)	4.27964183
5	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.27667795
6	Renal duplication (HP:0000075)	3.94956792
7	Chromsome breakage (HP:0040012)	3.87788648
8	Duplicated collecting system (HP:0000081)	3.82602633
9	Birth length less than 3rd percentile (HP:0003561)	3.52339678
10	Abnormality of the renal collecting system (HP:0004742)	3.51217420
11	Mesomelia (HP:0003027)	3.48233397
12	Sparse lateral eyebrow (HP:0005338)	3.22301856
13	Hypoplastic labia majora (HP:0000059)	3.08710098
14	Upper limb muscle weakness (HP:0003484)	3.07695450
15	Abnormality of DNA repair (HP:0003254)	3.02398225
16	Abnormality of the pons (HP:0007361)	2.90308677
17	Abnormality of the labia majora (HP:0012881)	2.88995840
18	Abnormality of alanine metabolism (HP:0010916)	2.87739511
19	Hyperalaninemia (HP:0003348)	2.87739511
20	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.87739511
21	Recurrent corneal erosions (HP:0000495)	2.81105032
22	Truncus arteriosus (HP:0001660)	2.79285599
23	Ileus (HP:0002595)	2.76671370
24	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	2.72863937
25	Relative macrocephaly (HP:0004482)	2.70495549
26	Small hand (HP:0200055)	2.65560133
27	Abnormality of chromosome stability (HP:0003220)	2.63370682
28	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.61758889
29	Poikiloderma (HP:0001029)	2.58738638
30	Follicular hyperkeratosis (HP:0007502)	2.53924945
31	Thick nail (HP:0001805)	2.51897455
32	Cone-rod dystrophy (HP:0000548)	2.48372841
33	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	2.39171273
34	Narrow palate (HP:0000189)	2.38646126
35	Hyperventilation (HP:0002883)	2.38408201
36	Ectropion (HP:0000656)	2.35224727
37	Febrile seizures (HP:0002373)	2.33710531
38	Clubbing of toes (HP:0100760)	2.30280591
39	Abnormality of dental color (HP:0011073)	2.30079968
40	Short 5th finger (HP:0009237)	2.29177209
41	Chorioretinal atrophy (HP:0000533)	2.29164793
42	Ankyloglossia (HP:0010296)	2.28583791
43	Male infertility (HP:0003251)	2.22698797
44	Type II lissencephaly (HP:0007260)	2.21848226
45	Abnormality of the preputium (HP:0100587)	2.21715108
46	Peripheral hypomyelination (HP:0007182)	2.21123013
47	Myoglobinuria (HP:0002913)	2.20632889
48	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	2.20354540
49	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.19905937
50	Meckel diverticulum (HP:0002245)	2.19521947
51	Central scotoma (HP:0000603)	2.17183950
52	Abnormal large intestine physiology (HP:0012700)	2.16039497
53	Hyperthyroidism (HP:0000836)	2.15686861
54	Midline defect of the nose (HP:0004122)	2.15052433
55	Tubulointerstitial nephritis (HP:0001970)	2.14405092
56	Scotoma (HP:0000575)	2.13471696
57	Absent radius (HP:0003974)	2.11032237
58	Bony spicule pigmentary retinopathy (HP:0007737)	2.08067361
59	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.07406887
60	Hypoplasia of the pons (HP:0012110)	2.06388130
61	True hermaphroditism (HP:0010459)	2.05981843
62	Absent forearm bone (HP:0003953)	2.05841552
63	Aplasia involving forearm bones (HP:0009822)	2.05841552
64	Cutaneous melanoma (HP:0012056)	2.05044652
65	Abnormality of cochlea (HP:0000375)	2.04703044
66	Duodenal stenosis (HP:0100867)	2.02861115
67	Small intestinal stenosis (HP:0012848)	2.02861115
68	Myelodysplasia (HP:0002863)	2.01287551
69	Tubular atrophy (HP:0000092)	2.00885038
70	Protruding tongue (HP:0010808)	1.99853873
71	Broad-based gait (HP:0002136)	1.99820758
72	Gaze-evoked nystagmus (HP:0000640)	1.96183688
73	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.95276552
74	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.94809225
75	Concave nail (HP:0001598)	1.94771930
76	Bowel incontinence (HP:0002607)	1.93139137
77	Short chin (HP:0000331)	1.91487668
78	Abnormality of the ileum (HP:0001549)	1.91373064
79	Hypokalemic alkalosis (HP:0001949)	1.89265507
80	Diaphragmatic weakness (HP:0009113)	1.88483924
81	Absent thumb (HP:0009777)	1.88445363
82	Cerebellar dysplasia (HP:0007033)	1.88043559
83	Ectopic kidney (HP:0000086)	1.87738472
84	Long palpebral fissure (HP:0000637)	1.86325947
85	Prostate neoplasm (HP:0100787)	1.84418171
86	Thin upper lip vermilion (HP:0000219)	1.83975503
87	Abnormality of the carotid arteries (HP:0005344)	1.82530887
88	Rhabdomyolysis (HP:0003201)	1.81388516
89	Hypoplastic iliac wings (HP:0002866)	1.80264253
90	Arteriovenous malformation (HP:0100026)	1.80135093
91	Increased serum ferritin (HP:0003281)	1.78545513
92	Pancreatic fibrosis (HP:0100732)	1.78313130
93	Morphological abnormality of the inner ear (HP:0011390)	1.78057530
94	Absent septum pellucidum (HP:0001331)	1.77960537
95	Sloping forehead (HP:0000340)	1.77458473
96	Venous insufficiency (HP:0005293)	1.77428760
97	Squamous cell carcinoma (HP:0002860)	1.76973040
98	Nephroblastoma (Wilms tumor) (HP:0002667)	1.75050352
99	Attenuation of retinal blood vessels (HP:0007843)	1.74187709
100	Obsessive-compulsive behavior (HP:0000722)	1.72913531

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK24	8.05971923
2	MAP4K2	7.57193584
3	FRK	3.19260397
4	CASK	2.99442451
5	AKT3	2.72302924
6	CAMK1D	2.35776802
7	CLK1	2.20530162
8	ILK	2.15911360
9	DYRK3	2.00646304
10	CAMK1G	1.97866714
11	EIF2AK1	1.75907017
12	NUAK1	1.75548859
13	WNK4	1.56815876
14	TTK	1.50485641
15	PNCK	1.46068049
16	BRSK2	1.41930224
17	TAOK3	1.39460773
18	ARAF	1.31486913
19	DDR2	1.30903969
20	CCNB1	1.27888187
21	WEE1	1.18747932
22	RAF1	1.12936650
23	ACVR1B	1.11207505
24	MAP3K13	1.06677428
25	GRK1	1.05709588
26	LATS2	1.05186500
27	ADRBK2	0.99844378
28	BMPR2	0.97818823
29	TRPM7	0.93615525
30	KSR2	0.91486599
31	STK39	0.90698258
32	PDGFRB	0.89923423
33	RIPK4	0.89821649
34	LATS1	0.89195008
35	MKNK2	0.88085555
36	TAF1	0.87600200
37	BRD4	0.87093028
38	PRKCQ	0.86429230
39	BCKDK	0.84345559
40	PBK	0.79960184
41	SGK3	0.79135494
42	BUB1	0.78744667
43	MAP3K9	0.77166442
44	ZAK	0.76137824
45	CDC7	0.75365580
46	BRAF	0.75177285
47	RPS6KA5	0.74593514
48	RPS6KA4	0.74589543
49	TRIM28	0.70611141
50	CAMK1	0.70331329
51	FGFR1	0.69304568
52	CHEK2	0.65096800
53	PLK4	0.63122631
54	KSR1	0.62461198
55	IRAK1	0.59846425
56	EIF2AK3	0.59090839
57	PLK3	0.58617048
58	BRSK1	0.58509776
59	FGFR2	0.58183149
60	MARK3	0.57453463
61	VRK1	0.56216272
62	NTRK3	0.55874600
63	ATM	0.55538948
64	IKBKB	0.55406451
65	STK4	0.53441979
66	TSSK6	0.53319613
67	STK3	0.52461203
68	MELK	0.50638394
69	CDK12	0.46811420
70	ATR	0.46212887
71	SGK2	0.45366498
72	PLK2	0.44806182
73	PKN1	0.44150724
74	BMPR1B	0.43935681
75	NLK	0.43639618
76	TYRO3	0.41957276
77	WNK1	0.39869034
78	PIK3CA	0.36843826
79	PIM1	0.35584487
80	MAP3K2	0.35278214
81	MAP2K3	0.34882517
82	IRAK3	0.34518625
83	CAMKK2	0.33810795
84	JAK2	0.32501598
85	SIK2	0.32317566
86	MAP3K10	0.31628930
87	PLK1	0.31624440
88	CHEK1	0.31301791
89	NEK6	0.30906983
90	SRPK1	0.30264087
91	MAP2K1	0.29828062
92	TNIK	0.29791058
93	MKNK1	0.29363673
94	CDK1	0.25646162
95	ALK	0.23548572
96	PIK3CG	0.21268632
97	JAK3	0.19676800
98	MAPK11	0.19633601
99	NEK1	0.18523677
100	MAPK8	0.16982214

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Mineral absorption_Homo sapiens_hsa04978	5.76709325
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	4.04388856
3	Nitrogen metabolism_Homo sapiens_hsa00910	3.81685252
4	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.38169179
5	Circadian rhythm_Homo sapiens_hsa04710	3.05954107
6	Selenocompound metabolism_Homo sapiens_hsa00450	2.75835996
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.53190819
8	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.49371951
9	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.22501476
10	Homologous recombination_Homo sapiens_hsa03440	2.19118016
11	Alcoholism_Homo sapiens_hsa05034	2.17416433
12	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.94183410
13	PPAR signaling pathway_Homo sapiens_hsa03320	1.79082387
14	Basal transcription factors_Homo sapiens_hsa03022	1.76645965
15	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.63785909
16	Propanoate metabolism_Homo sapiens_hsa00640	1.60579695
17	One carbon pool by folate_Homo sapiens_hsa00670	1.60328700
18	RNA degradation_Homo sapiens_hsa03018	1.51279788
19	Viral carcinogenesis_Homo sapiens_hsa05203	1.46925200
20	RNA polymerase_Homo sapiens_hsa03020	1.41962243
21	DNA replication_Homo sapiens_hsa03030	1.36518283
22	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.35144861
23	p53 signaling pathway_Homo sapiens_hsa04115	1.33448819
24	Fatty acid metabolism_Homo sapiens_hsa01212	1.31532897
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.29476739
26	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.29463195
27	Olfactory transduction_Homo sapiens_hsa04740	1.21151297
28	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.19021917
29	Base excision repair_Homo sapiens_hsa03410	1.18075310
30	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.16288584
31	mRNA surveillance pathway_Homo sapiens_hsa03015	1.14479793
32	Steroid biosynthesis_Homo sapiens_hsa00100	1.13751975
33	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.12540979
34	Caffeine metabolism_Homo sapiens_hsa00232	1.11024402
35	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.08772067
36	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.05098870
37	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.04108686
38	Pyruvate metabolism_Homo sapiens_hsa00620	1.02789423
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.01988291
40	Nicotine addiction_Homo sapiens_hsa05033	0.95961938
41	Cell cycle_Homo sapiens_hsa04110	0.95287593
42	Ether lipid metabolism_Homo sapiens_hsa00565	0.94826016
43	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.91538214
44	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.90212078
45	RNA transport_Homo sapiens_hsa03013	0.86872597
46	Chemical carcinogenesis_Homo sapiens_hsa05204	0.82338249
47	Mismatch repair_Homo sapiens_hsa03430	0.80252110
48	Butanoate metabolism_Homo sapiens_hsa00650	0.80099895
49	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.78392611
50	Linoleic acid metabolism_Homo sapiens_hsa00591	0.76226781
51	MicroRNAs in cancer_Homo sapiens_hsa05206	0.75673978
52	Retinol metabolism_Homo sapiens_hsa00830	0.75533983
53	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.72845912
54	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.72545536
55	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.70229246
56	Phototransduction_Homo sapiens_hsa04744	0.66476904
57	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.64235094
58	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.63622833
59	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.63373360
60	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.60326564
61	Peroxisome_Homo sapiens_hsa04146	0.60090137
62	ABC transporters_Homo sapiens_hsa02010	0.59968624
63	Taste transduction_Homo sapiens_hsa04742	0.56218303
64	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.55029313
65	Fatty acid degradation_Homo sapiens_hsa00071	0.54872413
66	Oocyte meiosis_Homo sapiens_hsa04114	0.53058925
67	ErbB signaling pathway_Homo sapiens_hsa04012	0.52284822
68	Melanoma_Homo sapiens_hsa05218	0.51099654
69	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.47800272
70	Insulin resistance_Homo sapiens_hsa04931	0.46961990
71	Regulation of autophagy_Homo sapiens_hsa04140	0.46680791
72	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.46469268
73	Glutathione metabolism_Homo sapiens_hsa00480	0.46009202
74	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.45640974
75	FoxO signaling pathway_Homo sapiens_hsa04068	0.43312379
76	Glycerolipid metabolism_Homo sapiens_hsa00561	0.42541579
77	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.40479689
78	Fat digestion and absorption_Homo sapiens_hsa04975	0.37864080
79	Arginine and proline metabolism_Homo sapiens_hsa00330	0.37026976
80	Complement and coagulation cascades_Homo sapiens_hsa04610	0.36415399
81	Purine metabolism_Homo sapiens_hsa00230	0.35707065
82	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.35647573
83	Choline metabolism in cancer_Homo sapiens_hsa05231	0.35261316
84	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.35247545
85	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.34276143
86	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.34274114
87	Insulin signaling pathway_Homo sapiens_hsa04910	0.34146400
88	Serotonergic synapse_Homo sapiens_hsa04726	0.33223992
89	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.32268387
90	Protein export_Homo sapiens_hsa03060	0.29987580
91	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.29881056
92	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.29384544
93	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.28892915
94	Pyrimidine metabolism_Homo sapiens_hsa00240	0.28425119
95	Amphetamine addiction_Homo sapiens_hsa05031	0.24890404
96	MAPK signaling pathway_Homo sapiens_hsa04010	0.23719938
97	Non-homologous end-joining_Homo sapiens_hsa03450	0.23385231
98	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.22497641
99	Cocaine addiction_Homo sapiens_hsa05030	0.20190056
100	Dopaminergic synapse_Homo sapiens_hsa04728	0.19016023

OR2W6P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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