OR3A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sleep (GO:0030431)9.06456590
2deoxyribonucleoside monophosphate metabolic process (GO:0009162)6.54961549
3adenosine metabolic process (GO:0046085)5.80395732
4GDP-mannose metabolic process (GO:0019673)4.45979522
5pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.45952604
6tolerance induction (GO:0002507)4.34613583
7cellular response to prostaglandin stimulus (GO:0071379)4.31784795
8male sex determination (GO:0030238)4.24648710
9negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.12150695
10glyoxylate metabolic process (GO:0046487)3.98202884
11regulation of cilium movement (GO:0003352)3.90806295
12fusion of sperm to egg plasma membrane (GO:0007342)3.82493467
13negative regulation of phagocytosis (GO:0050765)3.70530823
14regulation of B cell receptor signaling pathway (GO:0050855)3.64545352
15dosage compensation (GO:0007549)3.62626969
16response to gravity (GO:0009629)3.53641983
17chaperone mediated protein folding requiring cofactor (GO:0051085)3.53414360
18pyrimidine nucleotide catabolic process (GO:0006244)3.49751759
19piRNA metabolic process (GO:0034587)3.48249108
20phosphatidylglycerol biosynthetic process (GO:0006655)3.48129687
21positive regulation of prostaglandin secretion (GO:0032308)3.45750676
22rRNA modification (GO:0000154)3.45423376
23cellular response to interferon-beta (GO:0035458)3.44756040
24somatic hypermutation of immunoglobulin genes (GO:0016446)3.41859505
25somatic diversification of immune receptors via somatic mutation (GO:0002566)3.41859505
26response to muramyl dipeptide (GO:0032495)3.41446601
27natural killer cell activation involved in immune response (GO:0002323)3.41037756
28negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.30548884
29protein complex biogenesis (GO:0070271)3.29655883
30arginine catabolic process (GO:0006527)3.26318610
31regulation of germinal center formation (GO:0002634)3.24401640
32negative regulation of interleukin-1 beta production (GO:0032691)3.21795946
33negative regulation of interleukin-2 production (GO:0032703)3.21253993
34iron-sulfur cluster assembly (GO:0016226)3.17115412
35metallo-sulfur cluster assembly (GO:0031163)3.17115412
36mast cell degranulation (GO:0043303)3.15936837
37mast cell activation involved in immune response (GO:0002279)3.15936837
38S-adenosylmethionine metabolic process (GO:0046500)3.14641196
39pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.12346114
40positive regulation of odontogenesis (GO:0042482)3.12258747
41male meiosis I (GO:0007141)3.12030098
42xenobiotic catabolic process (GO:0042178)3.11913409
43plasma membrane fusion (GO:0045026)3.09990021
44DNA deamination (GO:0045006)3.08019958
45mitochondrial respiratory chain complex assembly (GO:0033108)3.04150513
46Arp2/3 complex-mediated actin nucleation (GO:0034314)3.03230011
47response to interferon-beta (GO:0035456)3.03044470
48dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.02908493
49regulation of prostaglandin secretion (GO:0032306)3.00143614
50L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.96955196
51positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.96212498
52ribosomal small subunit assembly (GO:0000028)2.93043836
53negative regulation of DNA-templated transcription, elongation (GO:0032785)2.92620289
54tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.88659837
55RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.88659837
56positive regulation of megakaryocyte differentiation (GO:0045654)2.86573850
57ubiquinone biosynthetic process (GO:0006744)2.85698839
58DNA strand elongation involved in DNA replication (GO:0006271)2.83692525
59cytochrome complex assembly (GO:0017004)2.83685347
60mannosylation (GO:0097502)2.82569906
61deoxyribose phosphate biosynthetic process (GO:0046385)2.81782638
622-deoxyribonucleotide biosynthetic process (GO:0009265)2.81782638
63positive regulation of microtubule polymerization (GO:0031116)2.81498427
64valine metabolic process (GO:0006573)2.80336396
65lymph vessel development (GO:0001945)2.78247404
66mucosal-associated lymphoid tissue development (GO:0048537)2.77803292
67Peyers patch development (GO:0048541)2.77803292
68deoxyribose phosphate catabolic process (GO:0046386)2.77378147
69negative regulation of Notch signaling pathway (GO:0045746)2.77255028
70oxidative demethylation (GO:0070989)2.74072715
71negative regulation of cell cycle arrest (GO:0071157)2.73425452
72positive regulation of B cell differentiation (GO:0045579)2.73342234
73organelle membrane fusion (GO:0090174)2.71780096
74DNA strand elongation (GO:0022616)2.70898802
75RNA destabilization (GO:0050779)2.70598033
76regulation of microtubule-based movement (GO:0060632)2.67016693
77multicellular organism reproduction (GO:0032504)2.65120063
78lysosome localization (GO:0032418)2.64148235
79respiratory chain complex IV assembly (GO:0008535)2.63753585
80histone H4-K12 acetylation (GO:0043983)2.62977199
81amino acid salvage (GO:0043102)2.62235796
82L-methionine salvage (GO:0071267)2.62235796
83L-methionine biosynthetic process (GO:0071265)2.62235796
84deoxyribonucleotide catabolic process (GO:0009264)2.59047531
85rRNA methylation (GO:0031167)2.55487059
86DNA methylation involved in gamete generation (GO:0043046)2.55316161
87actin nucleation (GO:0045010)2.55103102
88interkinetic nuclear migration (GO:0022027)2.54284688
89preassembly of GPI anchor in ER membrane (GO:0016254)2.52855132
90maturation of 5.8S rRNA (GO:0000460)2.51356337
91regulation of mitochondrial translation (GO:0070129)2.51168714
92regulation of mast cell degranulation (GO:0043304)2.50422737
93polyketide metabolic process (GO:0030638)2.49631563
94doxorubicin metabolic process (GO:0044598)2.49631563
95daunorubicin metabolic process (GO:0044597)2.49631563
96mast cell activation (GO:0045576)2.48470059
97transcription elongation from RNA polymerase III promoter (GO:0006385)2.48148084
98termination of RNA polymerase III transcription (GO:0006386)2.48148084
99positive regulation of transforming growth factor beta production (GO:0071636)2.47168204
100heme metabolic process (GO:0042168)2.46263050

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.40644970
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.76901381
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.21677319
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.00477429
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.63047882
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.58660856
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.56309579
8SCL_19346495_ChIP-Seq_HPC-7_Human2.54882815
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48092983
10CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.42472298
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35603170
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.25791142
13LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.23389980
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.22995470
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.10754659
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.98418454
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.96869270
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.96012452
19VDR_23849224_ChIP-Seq_CD4+_Human1.92853120
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92286962
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76424351
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.75730649
23RUNX_20019798_ChIP-Seq_JUKART_Human1.72060162
24BCL6_27268052_Chip-Seq_Bcells_Human1.71221031
25EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.69699341
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.69158938
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68540972
28ELF1_20517297_ChIP-Seq_JURKAT_Human1.68158944
29GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.67569538
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.65989605
31CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.64935624
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.64857897
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64124439
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63986548
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.61907079
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.60747818
37IRF1_19129219_ChIP-ChIP_H3396_Human1.60183257
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59500474
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.58082993
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56860201
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56098060
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.55378240
43E2F1_20622854_ChIP-Seq_HELA_Human1.55051536
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.53538027
45STAT1_20625510_ChIP-Seq_HELA_Human1.52731332
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51601981
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51139089
48VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.50816031
49FOXP3_21729870_ChIP-Seq_TREG_Human1.50100120
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49959132
51RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.48670782
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.47771928
53PHF8_20622854_ChIP-Seq_HELA_Human1.47405753
54EST1_17652178_ChIP-ChIP_JURKAT_Human1.46818263
55MYB_26560356_Chip-Seq_TH2_Human1.46289921
56SPI1_23547873_ChIP-Seq_NB4_Human1.44549001
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42310580
58P300_27268052_Chip-Seq_Bcells_Human1.42297213
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.37898387
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37279282
61CIITA_25753668_ChIP-Seq_RAJI_Human1.34729469
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33413325
63BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31458800
64P68_20966046_ChIP-Seq_HELA_Human1.31028557
65FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.29573890
66GABP_19822575_ChIP-Seq_HepG2_Human1.27744709
67BP1_19119308_ChIP-ChIP_Hs578T_Human1.27687795
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.27117775
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25925929
70MAF_26560356_Chip-Seq_TH2_Human1.25170971
71GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24223990
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23935038
73ERA_21632823_ChIP-Seq_H3396_Human1.23415323
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22070413
75GATA3_27048872_Chip-Seq_THYMUS_Human1.21824949
76GATA3_26560356_Chip-Seq_TH2_Human1.20572208
77CTCF_26484167_Chip-Seq_Bcells_Mouse1.19729175
78YY1_22570637_ChIP-Seq_MALME-3M_Human1.13488140
79UTX_26944678_Chip-Seq_JUKART_Human1.12821172
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11115841
81FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09393720
82SA1_27219007_Chip-Seq_Bcells_Human1.07472167
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07450061
84KDM5A_27292631_Chip-Seq_BREAST_Human1.06824896
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05655507
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05080792
87CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04976874
88PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04798701
89SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04184295
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03911503
91TET1_21451524_ChIP-Seq_MESCs_Mouse1.03639791
92CTCF_21964334_ChIP-Seq_BJAB-B_Human1.02946368
93ERG_20517297_ChIP-Seq_VCAP_Human0.98809709
94PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98462872
95IGF1R_20145208_ChIP-Seq_DFB_Human0.98244110
96VDR_21846776_ChIP-Seq_THP-1_Human0.97912046
97BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.97156402
98BCOR_27268052_Chip-Seq_Bcells_Human0.95296362
99CTCF_20526341_ChIP-Seq_ESCs_Human0.92926590
100CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92896826

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002876_abnormal_thyroid_physiology4.07007284
2MP0000465_gastrointestinal_hemorrhage3.82730227
3MP0002254_reproductive_system_inflammat3.40074715
4MP0008058_abnormal_DNA_repair3.24239769
5MP0005645_abnormal_hypothalamus_physiol3.21938249
6MP0003724_increased_susceptibility_to2.83081894
7MP0005451_abnormal_body_composition2.72338090
8MP0003436_decreased_susceptibility_to2.61402547
9MP0002160_abnormal_reproductive_system2.46301982
10MP0005646_abnormal_pituitary_gland2.30349385
11MP0008877_abnormal_DNA_methylation2.22370314
12MP0003183_abnormal_peptide_metabolism2.16461756
13MP0005671_abnormal_response_to2.09931989
14MP0004147_increased_porphyrin_level2.03484448
15MP0010094_abnormal_chromosome_stability2.02951948
16MP0005000_abnormal_immune_tolerance1.94756953
17MP0004133_heterotaxia1.88973585
18MP0005464_abnormal_platelet_physiology1.86734621
19MP0002139_abnormal_hepatobiliary_system1.85710710
20MP0001853_heart_inflammation1.78654080
21MP0003252_abnormal_bile_duct1.78401995
22MP0005389_reproductive_system_phenotype1.70146566
23MP0000383_abnormal_hair_follicle1.66867177
24MP0002405_respiratory_system_inflammati1.64634773
25MP0002909_abnormal_adrenal_gland1.64531336
26MP0003195_calcinosis1.60077753
27MP0005410_abnormal_fertilization1.57004545
28MP0005084_abnormal_gallbladder_morpholo1.56759667
29MP0001986_abnormal_taste_sensitivity1.55393473
30MP0000685_abnormal_immune_system1.54666887
31MP0003763_abnormal_thymus_physiology1.51230057
32MP0002723_abnormal_immune_serum1.50861997
33MP0003718_maternal_effect1.47889145
34MP0002419_abnormal_innate_immunity1.45352967
35MP0001819_abnormal_immune_cell1.44914056
36MP0001835_abnormal_antigen_presentation1.44822267
37MP0004145_abnormal_muscle_electrophysio1.43881490
38MP0005075_abnormal_melanosome_morpholog1.40610779
39MP0002420_abnormal_adaptive_immunity1.40346615
40MP0002148_abnormal_hypersensitivity_rea1.39151597
41MP0004019_abnormal_vitamin_homeostasis1.38161892
42MP0002452_abnormal_antigen_presenting1.36066692
43MP0003075_altered_response_to1.35668239
44MP0009785_altered_susceptibility_to1.33247511
45MP0000689_abnormal_spleen_morphology1.31657006
46MP0002102_abnormal_ear_morphology1.31156458
47MP0001851_eye_inflammation1.30084767
48MP0000013_abnormal_adipose_tissue1.29687141
49MP0005025_abnormal_response_to1.29663019
50MP0006036_abnormal_mitochondrial_physio1.26044140
51MP0002933_joint_inflammation1.24980244
52MP0002722_abnormal_immune_system1.23759654
53MP0002398_abnormal_bone_marrow1.22049044
54MP0003186_abnormal_redox_activity1.19108275
55MP0001533_abnormal_skeleton_physiology1.18295656
56MP0008872_abnormal_physiological_respon1.16406413
57MP0000003_abnormal_adipose_tissue1.15928725
58MP0000716_abnormal_immune_system1.15623394
59MP0002693_abnormal_pancreas_physiology1.14448553
60MP0003787_abnormal_imprinting1.13711422
61MP0001800_abnormal_humoral_immune1.13279787
62MP0005379_endocrine/exocrine_gland_phen1.10461033
63MP0005085_abnormal_gallbladder_physiolo1.09332418
64MP0000703_abnormal_thymus_morphology1.06739049
65MP0002019_abnormal_tumor_incidence1.05549995
66MP0001929_abnormal_gametogenesis1.03658658
67MP0002429_abnormal_blood_cell1.02869588
68MP0008789_abnormal_olfactory_epithelium1.00037705
69MP0005220_abnormal_exocrine_pancreas0.99625213
70MP0003638_abnormal_response/metabolism_0.98323087
71MP0001765_abnormal_ion_homeostasis0.95996291
72MP0003806_abnormal_nucleotide_metabolis0.94218323
73MP0002396_abnormal_hematopoietic_system0.93200520
74MP0005165_increased_susceptibility_to0.93078407
75MP0001119_abnormal_female_reproductive0.92648211
76MP0001845_abnormal_inflammatory_respons0.91903380
77MP0005395_other_phenotype0.89413366
78MP0005584_abnormal_enzyme/coenzyme_acti0.87930318
79MP0005397_hematopoietic_system_phenotyp0.85986485
80MP0001545_abnormal_hematopoietic_system0.85986485
81MP0002166_altered_tumor_susceptibility0.85080604
82MP0001501_abnormal_sleep_pattern0.84550720
83MP0008469_abnormal_protein_level0.84414011
84MP0003959_abnormal_lean_body0.83997481
85MP0010678_abnormal_skin_adnexa0.83306551
86MP0003879_abnormal_hair_cell0.83025330
87MP0000653_abnormal_sex_gland0.82907994
88MP0003698_abnormal_male_reproductive0.81641653
89MP0002998_abnormal_bone_remodeling0.80937989
90MP0008995_early_reproductive_senescence0.80918944
91MP0003283_abnormal_digestive_organ0.80747196
92MP0009763_increased_sensitivity_to0.80306261
93MP0009764_decreased_sensitivity_to0.77905320
94MP0003121_genomic_imprinting0.77791867
95MP0002210_abnormal_sex_determination0.77744804
96MP0009278_abnormal_bone_marrow0.77541976
97MP0001873_stomach_inflammation0.77495378
98MP0001145_abnormal_male_reproductive0.77234170
99MP0002006_tumorigenesis0.76443723
100MP0003172_abnormal_lysosome_physiology0.75933694

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.19795906
2Abnormality of the prostate (HP:0008775)4.29051615
3Visual hallucinations (HP:0002367)4.25955927
4Stomatitis (HP:0010280)3.94333085
5Hypoplasia of the pons (HP:0012110)3.81458471
6Abnormal protein glycosylation (HP:0012346)3.79657708
7Abnormal glycosylation (HP:0012345)3.79657708
8Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.79657708
9Abnormal protein N-linked glycosylation (HP:0012347)3.79657708
10Type I transferrin isoform profile (HP:0003642)3.66735756
11Pulmonary fibrosis (HP:0002206)3.46624209
12Abnormality of male internal genitalia (HP:0000022)3.30189858
13Abnormality of the pons (HP:0007361)3.20079660
14Fatigue (HP:0012378)3.16767504
15Abnormality of pyrimidine metabolism (HP:0004353)3.15593415
16Panhypogammaglobulinemia (HP:0003139)3.14647142
17Chronic obstructive pulmonary disease (HP:0006510)3.11784048
18Obstructive lung disease (HP:0006536)3.11784048
19Severe combined immunodeficiency (HP:0004430)3.02079676
20Poor head control (HP:0002421)2.90132310
21Focal motor seizures (HP:0011153)2.87155240
22Abnormality of dicarboxylic acid metabolism (HP:0010995)2.85888957
23Dicarboxylic aciduria (HP:0003215)2.85888957
24B lymphocytopenia (HP:0010976)2.78293762
25Ureteral stenosis (HP:0000071)2.75922163
263-Methylglutaconic aciduria (HP:0003535)2.74820895
27Reduced antithrombin III activity (HP:0001976)2.68665646
28Hepatocellular necrosis (HP:0001404)2.68427952
29Methylmalonic aciduria (HP:0012120)2.63000121
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.59276828
31Abnormality of alanine metabolism (HP:0010916)2.59276828
32Hyperalaninemia (HP:0003348)2.59276828
33Abnormality of liposaccharide metabolism (HP:0010968)2.59018872
34Abnormality of glycosphingolipid metabolism (HP:0004343)2.59018872
35Abnormality of glycolipid metabolism (HP:0010969)2.59018872
36Abnormality of B cell number (HP:0010975)2.57860727
37IgG deficiency (HP:0004315)2.56622238
38Metaphyseal dysplasia (HP:0100255)2.54828753
39Male infertility (HP:0003251)2.51570898
40Ureteral obstruction (HP:0006000)2.48547548
41Reticulocytopenia (HP:0001896)2.48262904
42Myopathic facies (HP:0002058)2.47514977
43Pancytopenia (HP:0001876)2.46880682
44Hypergonadotropic hypogonadism (HP:0000815)2.45494820
45Combined immunodeficiency (HP:0005387)2.45025841
46Recurrent fungal infections (HP:0002841)2.44351221
47Congenital stationary night blindness (HP:0007642)2.43165345
48Increased neuronal autofluorescent lipopigment (HP:0002074)2.35275358
49Chest pain (HP:0100749)2.29246272
50Hepatic necrosis (HP:0002605)2.27741628
51Abnormal spermatogenesis (HP:0008669)2.26025291
52Increased muscle lipid content (HP:0009058)2.25460158
53Pulmonary infiltrates (HP:0002113)2.23550788
54Abnormal rod and cone electroretinograms (HP:0008323)2.23119025
55Increased serum lactate (HP:0002151)2.22864239
56Increased intramyocellular lipid droplets (HP:0012240)2.18461353
57Lipid accumulation in hepatocytes (HP:0006561)2.12875747
58Ragged-red muscle fibers (HP:0003200)2.12012670
59Polyneuropathy (HP:0001271)2.10236534
60Clumsiness (HP:0002312)2.09814262
61Thrombocytosis (HP:0001894)2.08033202
62Aplastic anemia (HP:0001915)2.04112665
63Eczematoid dermatitis (HP:0000976)2.03071917
64Dry hair (HP:0011359)2.02454440
65Abnormal hair laboratory examination (HP:0003328)2.00034197
66Abnormality of the pericardium (HP:0001697)1.97805366
67Flat capital femoral epiphysis (HP:0003370)1.97744734
68Increased cerebral lipofuscin (HP:0011813)1.97109905
69Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.96687492
70Petechiae (HP:0000967)1.96032365
71Abnormality of T cell physiology (HP:0011840)1.95762059
72Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92406462
73Gangrene (HP:0100758)1.91957323
74Restrictive lung disease (HP:0002091)1.90493906
75Hepatosplenomegaly (HP:0001433)1.89213429
76Epistaxis (HP:0000421)1.88790347
77Abnormality of the lower motor neuron (HP:0002366)1.88100132
78Short middle phalanx of the 5th finger (HP:0004220)1.86436474
79Vasculitis (HP:0002633)1.85847555
80Agammaglobulinemia (HP:0004432)1.84320389
81Progressive muscle weakness (HP:0003323)1.81690816
82Pancreatic cysts (HP:0001737)1.81219424
83Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.79867015
84Abnormality of midbrain morphology (HP:0002418)1.78943078
85Molar tooth sign on MRI (HP:0002419)1.78943078
86Hemoptysis (HP:0002105)1.78895059
87Absent thumb (HP:0009777)1.78369785
88Abnormality of the pleura (HP:0002103)1.78183489
89Abnormality of the phalanges of the 2nd finger (HP:0009541)1.77496690
90Granulocytopenia (HP:0001913)1.77212358
91Severe global developmental delay (HP:0011344)1.76478090
92Neutropenia (HP:0001875)1.76005886
93Skin rash (HP:0000988)1.74776730
94Abnormality of DNA repair (HP:0003254)1.74656169
95Abnormal biliary tract physiology (HP:0012439)1.74064466
96Bile duct proliferation (HP:0001408)1.74064466
97Leukocytosis (HP:0001974)1.73483017
98Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.72036733
99Methylmalonic acidemia (HP:0002912)1.71020211
100Lactic acidosis (HP:0003128)1.70484743

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.71597991
2FES3.47711683
3ERN13.16438903
4ARAF2.86922714
5MUSK2.64705319
6GRK62.51532172
7MAP3K142.48177514
8IKBKE2.48085835
9TBK12.34822666
10NUAK12.27697388
11ZAK2.23920701
12TESK22.15079935
13IKBKB2.13496605
14WNK42.12898908
15SCYL22.08810467
16VRK22.01471057
17TXK2.00392901
18KIT1.89961074
19MAP2K21.86467969
20GRK71.86093977
21MAP3K111.84935980
22KDR1.82707658
23STK391.80454231
24EPHA31.80447105
25MOS1.74271224
26BCKDK1.72204549
27PIM21.67495360
28ABL21.66603287
29CCNB11.65999543
30TGFBR21.47945238
31RPS6KA41.39178861
32MAP4K21.38292281
33DYRK31.32833301
34PDK21.30008157
35CDC71.23961866
36ATR1.19290477
37JAK31.13650635
38CDK71.12599645
39IRAK11.09337716
40EIF2AK21.06940868
41TESK11.04327512
42OXSR11.04249511
43PIM11.00009400
44AURKA0.97809886
45ITK0.96787730
46TLK10.86908609
47TEC0.84224698
48GRK50.82105543
49RPS6KA50.81893876
50GRK10.81434573
51MAPK110.80639868
52BTK0.79997092
53EPHB10.78121043
54LYN0.78067332
55MAP3K40.73808000
56RPS6KA20.70530539
57BRAF0.67224709
58LRRK20.66472016
59STK100.65779836
60PRKCQ0.65681643
61TIE10.65427508
62SYK0.64347497
63IRAK30.64325336
64LCK0.64001850
65TAOK20.62858253
66JAK10.59529471
67RPS6KA60.58337035
68RAF10.58160447
69RPS6KA10.57915739
70RPS6KC10.57494512
71RPS6KL10.57494512
72ZAP700.57295470
73TNK20.56596540
74FRK0.56427528
75MAP4K10.55609914
76CHEK20.53390013
77BMX0.52615928
78ADRBK20.52595252
79BMPR20.50763915
80AKT20.49129410
81NME10.48944642
82DYRK20.45825457
83NEK10.43777484
84NME20.43687070
85PHKG20.40796359
86PHKG10.40796359
87IGF1R0.39898776
88MAPK30.39452498
89DAPK10.37342461
90VRK10.36930619
91MAP3K10.36029444
92PRKCD0.35969851
93CAMK2D0.35899731
94MAPKAPK20.33779457
95INSRR0.32113204
96MAP2K30.31765860
97MARK30.31333209
98HIPK20.31049305
99LIMK10.30718221
100CDK40.30648619

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004005.30395004
2DNA replication_Homo sapiens_hsa030303.50947450
3Primary immunodeficiency_Homo sapiens_hsa053402.91461430
4Non-homologous end-joining_Homo sapiens_hsa034502.61102705
5Phenylalanine metabolism_Homo sapiens_hsa003602.35600851
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.26301294
7Base excision repair_Homo sapiens_hsa034102.09934119
8RNA polymerase_Homo sapiens_hsa030202.08281500
9Homologous recombination_Homo sapiens_hsa034402.01640612
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.99932168
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.96031319
12One carbon pool by folate_Homo sapiens_hsa006701.92061269
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.84169716
14Sulfur metabolism_Homo sapiens_hsa009201.79072481
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.77272769
16Mismatch repair_Homo sapiens_hsa034301.63354340
17Oxidative phosphorylation_Homo sapiens_hsa001901.51555069
18Type I diabetes mellitus_Homo sapiens_hsa049401.49699123
19Pyrimidine metabolism_Homo sapiens_hsa002401.49363485
20Parkinsons disease_Homo sapiens_hsa050121.48542909
21Fatty acid elongation_Homo sapiens_hsa000621.47478826
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47218078
23Graft-versus-host disease_Homo sapiens_hsa053321.46790229
24Fanconi anemia pathway_Homo sapiens_hsa034601.43506055
25Antigen processing and presentation_Homo sapiens_hsa046121.42072218
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.41905695
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.34269716
28Selenocompound metabolism_Homo sapiens_hsa004501.33297859
29Arachidonic acid metabolism_Homo sapiens_hsa005901.31941908
30Asthma_Homo sapiens_hsa053101.31190526
31Ribosome_Homo sapiens_hsa030101.29790225
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28838944
33Peroxisome_Homo sapiens_hsa041461.28654168
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21671909
35Tryptophan metabolism_Homo sapiens_hsa003801.20887874
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18694106
37Purine metabolism_Homo sapiens_hsa002301.16722020
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16721828
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15832198
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.15596079
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12676837
42Phototransduction_Homo sapiens_hsa047441.11643948
43Sulfur relay system_Homo sapiens_hsa041221.07966665
44Tyrosine metabolism_Homo sapiens_hsa003501.07905853
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07172874
46Proteasome_Homo sapiens_hsa030501.05976050
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05591868
48Allograft rejection_Homo sapiens_hsa053301.04971411
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03349062
50Huntingtons disease_Homo sapiens_hsa050161.02564411
51Glutathione metabolism_Homo sapiens_hsa004801.02540000
52Arginine biosynthesis_Homo sapiens_hsa002201.00560437
53Fructose and mannose metabolism_Homo sapiens_hsa000510.97407450
54Autoimmune thyroid disease_Homo sapiens_hsa053200.92291045
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91008906
56Chemical carcinogenesis_Homo sapiens_hsa052040.90797194
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.81698855
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81249670
59Pentose phosphate pathway_Homo sapiens_hsa000300.77938584
60Linoleic acid metabolism_Homo sapiens_hsa005910.75851595
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75650595
62Vitamin digestion and absorption_Homo sapiens_hsa049770.75513092
63Renin-angiotensin system_Homo sapiens_hsa046140.72870505
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70917728
65N-Glycan biosynthesis_Homo sapiens_hsa005100.70306349
66Protein export_Homo sapiens_hsa030600.70161609
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68646719
68Glycerolipid metabolism_Homo sapiens_hsa005610.67614661
69Metabolic pathways_Homo sapiens_hsa011000.66165350
70Leishmaniasis_Homo sapiens_hsa051400.65903147
71Rheumatoid arthritis_Homo sapiens_hsa053230.63624257
72Herpes simplex infection_Homo sapiens_hsa051680.63084695
73Butanoate metabolism_Homo sapiens_hsa006500.61642448
74Biosynthesis of amino acids_Homo sapiens_hsa012300.60605531
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59858052
76Alzheimers disease_Homo sapiens_hsa050100.59367170
77Renin secretion_Homo sapiens_hsa049240.59064282
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58721716
79Carbon metabolism_Homo sapiens_hsa012000.53060874
80Sphingolipid metabolism_Homo sapiens_hsa006000.48639189
81Cardiac muscle contraction_Homo sapiens_hsa042600.47084967
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46420082
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46368417
84RNA degradation_Homo sapiens_hsa030180.45543704
85Hematopoietic cell lineage_Homo sapiens_hsa046400.41688249
86Retinol metabolism_Homo sapiens_hsa008300.40034376
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.38832347
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37461127
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37411479
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36130770
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35545788
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.34941931
93Pertussis_Homo sapiens_hsa051330.33850950
94Ether lipid metabolism_Homo sapiens_hsa005650.33320767
95Legionellosis_Homo sapiens_hsa051340.33258858
96Lysosome_Homo sapiens_hsa041420.32861408
97Spliceosome_Homo sapiens_hsa030400.32672747
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.32240115
99Starch and sucrose metabolism_Homo sapiens_hsa005000.30533403
100ABC transporters_Homo sapiens_hsa020100.28876617

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