ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.79893345
2	fucose catabolic process (GO:0019317)	4.32192298
3	L-fucose metabolic process (GO:0042354)	4.32192298
4	L-fucose catabolic process (GO:0042355)	4.32192298
5	platelet dense granule organization (GO:0060155)	3.75980095
6	response to pheromone (GO:0019236)	3.74520397
7	DNA deamination (GO:0045006)	3.71936414
8	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.71816470
9	cellular ketone body metabolic process (GO:0046950)	3.67961018
10	preassembly of GPI anchor in ER membrane (GO:0016254)	3.63120525
11	protein localization to cilium (GO:0061512)	3.57183338
12	cornea development in camera-type eye (GO:0061303)	3.51200601
13	protein polyglutamylation (GO:0018095)	3.47462908
14	neural tube formation (GO:0001841)	3.44425248
15	indolalkylamine metabolic process (GO:0006586)	3.41088345
16	tryptophan catabolic process (GO:0006569)	3.33583770
17	indole-containing compound catabolic process (GO:0042436)	3.33583770
18	indolalkylamine catabolic process (GO:0046218)	3.33583770
19	axoneme assembly (GO:0035082)	3.30794987
20	ketone body metabolic process (GO:1902224)	3.29859559
21	nonmotile primary cilium assembly (GO:0035058)	3.27908147
22	retinal cone cell development (GO:0046549)	3.17935835
23	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.14760495
24	negative regulation of mast cell activation (GO:0033004)	3.14690468
25	epithelial cilium movement (GO:0003351)	3.12420229
26	photoreceptor cell maintenance (GO:0045494)	3.10946564
27	respiratory chain complex IV assembly (GO:0008535)	3.10304139
28	kynurenine metabolic process (GO:0070189)	3.07715403
29	cilium morphogenesis (GO:0060271)	3.07546799
30	detection of light stimulus involved in sensory perception (GO:0050962)	3.04850831
31	detection of light stimulus involved in visual perception (GO:0050908)	3.04850831
32	regulation of cilium movement (GO:0003352)	3.04611006
33	synaptic transmission, cholinergic (GO:0007271)	3.03647537
34	regulation of hexokinase activity (GO:1903299)	2.96383812
35	regulation of glucokinase activity (GO:0033131)	2.96383812
36	water-soluble vitamin biosynthetic process (GO:0042364)	2.93528679
37	adaptation of signaling pathway (GO:0023058)	2.92889708
38	S-adenosylmethionine metabolic process (GO:0046500)	2.90596802
39	tryptophan metabolic process (GO:0006568)	2.89527765
40	regulation of action potential (GO:0098900)	2.88076813
41	glycerophospholipid catabolic process (GO:0046475)	2.87114174
42	GPI anchor metabolic process (GO:0006505)	2.86917672
43	cilium organization (GO:0044782)	2.86868219
44	neuronal action potential (GO:0019228)	2.86837063
45	photoreceptor cell development (GO:0042461)	2.85641334
46	pyrimidine nucleobase catabolic process (GO:0006208)	2.82692770
47	indole-containing compound metabolic process (GO:0042430)	2.82527856
48	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.80681265
49	cilium assembly (GO:0042384)	2.80233305
50	behavioral response to ethanol (GO:0048149)	2.76303374
51	protein complex biogenesis (GO:0070271)	2.75009086
52	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.73927020
53	NADH dehydrogenase complex assembly (GO:0010257)	2.73927020
54	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.73927020
55	establishment of protein localization to Golgi (GO:0072600)	2.73264389
56	nucleobase catabolic process (GO:0046113)	2.70031692
57	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.69797486
58	piRNA metabolic process (GO:0034587)	2.67538233
59	somite development (GO:0061053)	2.66759383
60	reflex (GO:0060004)	2.64989747
61	transmission of nerve impulse (GO:0019226)	2.63255877
62	cytochrome complex assembly (GO:0017004)	2.62767989
63	primary amino compound metabolic process (GO:1901160)	2.62700876
64	negative regulation of heart rate (GO:0010459)	2.62209721
65	serotonin metabolic process (GO:0042428)	2.60074633
66	DNA double-strand break processing (GO:0000729)	2.59159258
67	cilium movement (GO:0003341)	2.57712384
68	neuronal action potential propagation (GO:0019227)	2.55765871
69	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.55665909
70	startle response (GO:0001964)	2.53988249
71	negative regulation of telomere maintenance (GO:0032205)	2.52948395
72	dopamine transport (GO:0015872)	2.51790808
73	intraciliary transport (GO:0042073)	2.51298531
74	mitochondrial respiratory chain complex assembly (GO:0033108)	2.50461234
75	GPI anchor biosynthetic process (GO:0006506)	2.50340475
76	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.49372999
77	eye photoreceptor cell development (GO:0042462)	2.48645791
78	mannosylation (GO:0097502)	2.48562728
79	inositol phosphate catabolic process (GO:0071545)	2.48391753
80	auditory receptor cell stereocilium organization (GO:0060088)	2.48147618
81	C-terminal protein lipidation (GO:0006501)	2.46373612
82	C-terminal protein amino acid modification (GO:0018410)	2.44420321
83	protein-cofactor linkage (GO:0018065)	2.44007959
84	benzene-containing compound metabolic process (GO:0042537)	2.43296268
85	thyroid hormone metabolic process (GO:0042403)	2.43270034
86	signal peptide processing (GO:0006465)	2.42509046
87	anterograde synaptic vesicle transport (GO:0048490)	2.41189941
88	dendritic spine morphogenesis (GO:0060997)	2.41040072
89	retinal ganglion cell axon guidance (GO:0031290)	2.40950656
90	prenylation (GO:0097354)	2.39862239
91	protein prenylation (GO:0018342)	2.39862239
92	reciprocal DNA recombination (GO:0035825)	2.39856164
93	reciprocal meiotic recombination (GO:0007131)	2.39856164
94	kidney morphogenesis (GO:0060993)	2.39406565
95	parental behavior (GO:0060746)	2.39372005
96	regulation of timing of cell differentiation (GO:0048505)	2.39280452
97	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.38958727
98	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.36841057
99	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.36841057
100	parturition (GO:0007567)	2.35481444

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.65227888
2	VDR_22108803_ChIP-Seq_LS180_Human	3.18634208
3	IGF1R_20145208_ChIP-Seq_DFB_Human	2.99811961
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.98199962
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.82984011
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.81173106
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.60787598
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.45124223
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.44117161
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.42866454
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.34623240
12	FUS_26573619_Chip-Seq_HEK293_Human	2.31820510
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.31344720
14	EWS_26573619_Chip-Seq_HEK293_Human	2.21331788
15	P300_19829295_ChIP-Seq_ESCs_Human	2.16809050
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.11980817
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.03794084
18	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.96913660
19	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.94975946
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.94117255
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.84177557
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.73850133
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.68764023
24	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.66620489
25	CBP_20019798_ChIP-Seq_JUKART_Human	1.65310030
26	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.65310030
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.63229051
28	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.60568729
29	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.59895406
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.58905667
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.58550229
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.56106278
33	STAT3_23295773_ChIP-Seq_U87_Human	1.55003457
34	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.53520529
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.52726674
36	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.51734272
37	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.49274625
38	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.49095483
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.48319192
40	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.48316647
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.47789501
42	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.47595490
43	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.47003067
44	TCF4_23295773_ChIP-Seq_U87_Human	1.45440208
45	AR_25329375_ChIP-Seq_VCAP_Human	1.43971820
46	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42865754
47	BCAT_22108803_ChIP-Seq_LS180_Human	1.42346007
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.41713618
49	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.41067981
50	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.40862871
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.40826186
52	TP53_22573176_ChIP-Seq_HFKS_Human	1.36094294
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35650159
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35650159
55	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.34397294
56	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.33597208
57	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.33233050
58	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.33021064
59	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31822031
60	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.31822031
61	RUNX2_22187159_ChIP-Seq_PCA_Human	1.30602696
62	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.29294272
63	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.29294272
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.29291981
65	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.27202906
66	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.27117749
67	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.27014585
68	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.26911721
69	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.26795913
70	RNF2_27304074_Chip-Seq_NSC_Mouse	1.26115001
71	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.25728135
72	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.23376551
73	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.22844479
74	MYC_18940864_ChIP-ChIP_HL60_Human	1.21943054
75	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21319599
76	P53_22387025_ChIP-Seq_ESCs_Mouse	1.19984168
77	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.18482927
78	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.18401122
79	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.18239568
80	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.17991436
81	REST_21632747_ChIP-Seq_MESCs_Mouse	1.17331187
82	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.16969118
83	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.13828502
84	ELK1_19687146_ChIP-ChIP_HELA_Human	1.10711674
85	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10305509
86	NCOR_22424771_ChIP-Seq_293T_Human	1.08727274
87	AR_21572438_ChIP-Seq_LNCaP_Human	1.08122899
88	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.07768823
89	AR_20517297_ChIP-Seq_VCAP_Human	1.06075166
90	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.06023457
91	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05671325
92	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.05031762
93	CDX2_22108803_ChIP-Seq_LS180_Human	1.04560645
94	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.03511111
95	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02594542
96	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.01534874
97	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.00458882
98	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.00331728
99	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.99807309
100	P300_18555785_Chip-Seq_ESCs_Mouse	0.98129379

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	2.92816112
2	MP0003880_abnormal_central_pattern	2.92590693
3	MP0008877_abnormal_DNA_methylation	2.85859848
4	MP0002102_abnormal_ear_morphology	2.60474515
5	MP0003787_abnormal_imprinting	2.58157604
6	MP0006292_abnormal_olfactory_placode	2.57261444
7	MP0005551_abnormal_eye_electrophysiolog	2.40102234
8	MP0006072_abnormal_retinal_apoptosis	2.37445738
9	MP0001968_abnormal_touch/_nociception	2.26392248
10	MP0002736_abnormal_nociception_after	2.18755464
11	MP0003195_calcinosis	2.16249149
12	MP0002638_abnormal_pupillary_reflex	2.10280373
13	MP0001984_abnormal_olfaction	2.03533887
14	MP0005253_abnormal_eye_physiology	2.02707973
15	MP0009046_muscle_twitch	2.01723854
16	MP0005645_abnormal_hypothalamus_physiol	1.98471712
17	MP0006276_abnormal_autonomic_nervous	1.96986374
18	MP0002876_abnormal_thyroid_physiology	1.93052725
19	MP0005646_abnormal_pituitary_gland	1.89469260
20	MP0000372_irregular_coat_pigmentation	1.88257641
21	MP0002837_dystrophic_cardiac_calcinosis	1.85760994
22	MP0004142_abnormal_muscle_tone	1.80080351
23	MP0001501_abnormal_sleep_pattern	1.75634695
24	MP0004885_abnormal_endolymph	1.71340671
25	MP0001529_abnormal_vocalization	1.71004207
26	MP0009745_abnormal_behavioral_response	1.68931798
27	MP0008872_abnormal_physiological_respon	1.67341529
28	MP0002272_abnormal_nervous_system	1.63808857
29	MP0004147_increased_porphyrin_level	1.61706319
30	MP0010386_abnormal_urinary_bladder	1.60200681
31	MP0008875_abnormal_xenobiotic_pharmacok	1.59505206
32	MP0001986_abnormal_taste_sensitivity	1.59317840
33	MP0004133_heterotaxia	1.56888518
34	MP0003011_delayed_dark_adaptation	1.56091930
35	MP0000427_abnormal_hair_cycle	1.53550573
36	MP0000631_abnormal_neuroendocrine_gland	1.50338956
37	MP0003646_muscle_fatigue	1.46799112
38	MP0005379_endocrine/exocrine_gland_phen	1.41737824
39	MP0002163_abnormal_gland_morphology	1.41629424
40	MP0004043_abnormal_pH_regulation	1.41526418
41	MP0002938_white_spotting	1.40808883
42	MP0001486_abnormal_startle_reflex	1.40504876
43	MP0005084_abnormal_gallbladder_morpholo	1.35595264
44	MP0002928_abnormal_bile_duct	1.29109277
45	MP0002254_reproductive_system_inflammat	1.28660230
46	MP0002557_abnormal_social/conspecific_i	1.27623185
47	MP0001970_abnormal_pain_threshold	1.27258941
48	MP0002572_abnormal_emotion/affect_behav	1.26561257
49	MP0005174_abnormal_tail_pigmentation	1.25008309
50	MP0002751_abnormal_autonomic_nervous	1.23715479
51	MP0002234_abnormal_pharynx_morphology	1.23425479
52	MP0001485_abnormal_pinna_reflex	1.20936790
53	MP0008995_early_reproductive_senescence	1.20572272
54	MP0008789_abnormal_olfactory_epithelium	1.18118502
55	MP0002095_abnormal_skin_pigmentation	1.17567294
56	MP0004924_abnormal_behavior	1.14075729
57	MP0005386_behavior/neurological_phenoty	1.14075729
58	MP0005389_reproductive_system_phenotype	1.13532326
59	MP0005075_abnormal_melanosome_morpholog	1.12816052
60	MP0002909_abnormal_adrenal_gland	1.11324464
61	MP0002067_abnormal_sensory_capabilities	1.10277345
62	MP0002733_abnormal_thermal_nociception	1.09966168
63	MP0003121_genomic_imprinting	1.09828636
64	MP0002064_seizures	1.09485045
65	MP0004742_abnormal_vestibular_system	1.08221795
66	MP0003890_abnormal_embryonic-extraembry	1.07724224
67	MP0004215_abnormal_myocardial_fiber	1.06922696
68	MP0005187_abnormal_penis_morphology	1.06189135
69	MP0002160_abnormal_reproductive_system	1.05652576
70	MP0001764_abnormal_homeostasis	1.05209757
71	MP0003136_yellow_coat_color	1.02834453
72	MP0002063_abnormal_learning/memory/cond	1.00977426
73	MP0000647_abnormal_sebaceous_gland	1.00750743
74	MP0003635_abnormal_synaptic_transmissio	0.99541811
75	MP0005195_abnormal_posterior_eye	0.99159961
76	MP0002735_abnormal_chemical_nociception	0.97415577
77	MP0000778_abnormal_nervous_system	0.97238909
78	MP0001905_abnormal_dopamine_level	0.96513675
79	MP0001919_abnormal_reproductive_system	0.95352845
80	MP0002184_abnormal_innervation	0.94202806
81	MP0000383_abnormal_hair_follicle	0.93045917
82	MP0002752_abnormal_somatic_nervous	0.88322197
83	MP0002229_neurodegeneration	0.88014054
84	MP0005394_taste/olfaction_phenotype	0.87142313
85	MP0005499_abnormal_olfactory_system	0.87142313
86	MP0004145_abnormal_muscle_electrophysio	0.84657296
87	MP0005423_abnormal_somatic_nervous	0.84605102
88	MP0000230_abnormal_systemic_arterial	0.82725167
89	MP0001188_hyperpigmentation	0.82458816
90	MP0003122_maternal_imprinting	0.82069621
91	MP0002734_abnormal_mechanical_nocicepti	0.81231218
92	MP0001324_abnormal_eye_pigmentation	0.80619156
93	MP0000015_abnormal_ear_pigmentation	0.79095371
94	MP0002822_catalepsy	0.78769655
95	MP0003137_abnormal_impulse_conducting	0.78156810
96	MP0008775_abnormal_heart_ventricle	0.76411392
97	MP0005391_vision/eye_phenotype	0.74627340
98	MP0001963_abnormal_hearing_physiology	0.73487558
99	MP0003698_abnormal_male_reproductive	0.73419603
100	MP0005167_abnormal_blood-brain_barrier	0.73406492

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.11001081
2	Pancreatic fibrosis (HP:0100732)	4.04554383
3	Abnormality of midbrain morphology (HP:0002418)	3.73070329
4	Molar tooth sign on MRI (HP:0002419)	3.73070329
5	True hermaphroditism (HP:0010459)	3.70267165
6	Nephronophthisis (HP:0000090)	3.58536147
7	Congenital stationary night blindness (HP:0007642)	3.50076710
8	Medial flaring of the eyebrow (HP:0010747)	3.46241619
9	Abnormality of the renal cortex (HP:0011035)	3.32488552
10	Abnormality of the renal medulla (HP:0100957)	3.14287600
11	Renal cortical cysts (HP:0000803)	3.00285012
12	Type II lissencephaly (HP:0007260)	2.95406378
13	Gait imbalance (HP:0002141)	2.92016846
14	Methylmalonic acidemia (HP:0002912)	2.88079509
15	Congenital primary aphakia (HP:0007707)	2.87083629
16	Attenuation of retinal blood vessels (HP:0007843)	2.82117475
17	Abolished electroretinogram (ERG) (HP:0000550)	2.74235741
18	Nephrogenic diabetes insipidus (HP:0009806)	2.62488402
19	Cystic liver disease (HP:0006706)	2.53807154
20	Chronic hepatic failure (HP:0100626)	2.53551870
21	Abnormal rod and cone electroretinograms (HP:0008323)	2.52286233
22	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.48063309
23	Hypoplasia of the fovea (HP:0007750)	2.48063309
24	Hyperventilation (HP:0002883)	2.46882253
25	Progressive inability to walk (HP:0002505)	2.46485191
26	Tubular atrophy (HP:0000092)	2.41955967
27	Pendular nystagmus (HP:0012043)	2.38765414
28	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.38246333
29	Hypothermia (HP:0002045)	2.36634351
30	Genital tract atresia (HP:0001827)	2.36547426
31	Intestinal atresia (HP:0011100)	2.34749260
32	Sclerocornea (HP:0000647)	2.32640266
33	Decreased central vision (HP:0007663)	2.32162903
34	Postaxial foot polydactyly (HP:0001830)	2.30413932
35	Inability to walk (HP:0002540)	2.26731593
36	Vaginal atresia (HP:0000148)	2.25961745
37	Congenital hepatic fibrosis (HP:0002612)	2.22343370
38	Acute necrotizing encephalopathy (HP:0006965)	2.21263154
39	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.20629783
40	Keratoconus (HP:0000563)	2.19307445
41	Increased corneal curvature (HP:0100692)	2.19307445
42	Congenital, generalized hypertrichosis (HP:0004540)	2.17796381
43	Broad-based gait (HP:0002136)	2.16544047
44	Optic nerve hypoplasia (HP:0000609)	2.14266885
45	Lissencephaly (HP:0001339)	2.13753829
46	Methylmalonic aciduria (HP:0012120)	2.12494594
47	Progressive macrocephaly (HP:0004481)	2.09870547
48	Abnormality of the fovea (HP:0000493)	2.09853716
49	Postaxial hand polydactyly (HP:0001162)	2.09251620
50	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.09242726
51	Increased CSF lactate (HP:0002490)	2.08640971
52	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.08381662
53	Acute encephalopathy (HP:0006846)	2.07223724
54	Stomatitis (HP:0010280)	2.03828384
55	Mitochondrial inheritance (HP:0001427)	2.02428395
56	Median cleft lip (HP:0000161)	2.01623107
57	Polydipsia (HP:0001959)	2.01518447
58	Abnormal drinking behavior (HP:0030082)	2.01518447
59	Febrile seizures (HP:0002373)	2.01465925
60	Hyperglycinemia (HP:0002154)	1.99608197
61	Thyroiditis (HP:0100646)	1.98339831
62	Bony spicule pigmentary retinopathy (HP:0007737)	1.95774375
63	Poor coordination (HP:0002370)	1.93302166
64	Absent/shortened dynein arms (HP:0200106)	1.92992801
65	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.92992801
66	Pachygyria (HP:0001302)	1.92586690
67	Abnormal biliary tract physiology (HP:0012439)	1.92263316
68	Bile duct proliferation (HP:0001408)	1.92263316
69	Abnormality of vitamin B metabolism (HP:0004340)	1.91717933
70	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.91164717
71	Anencephaly (HP:0002323)	1.90589067
72	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.90176651
73	Tubulointerstitial nephritis (HP:0001970)	1.90052400
74	Male pseudohermaphroditism (HP:0000037)	1.89665716
75	Optic disc pallor (HP:0000543)	1.88666728
76	Cerebellar dysplasia (HP:0007033)	1.88578088
77	Gaze-evoked nystagmus (HP:0000640)	1.87621745
78	Short tibia (HP:0005736)	1.85719282
79	Thyroid-stimulating hormone excess (HP:0002925)	1.84316609
80	Preaxial hand polydactyly (HP:0001177)	1.84060400
81	Focal motor seizures (HP:0011153)	1.83232317
82	Asplenia (HP:0001746)	1.83153199
83	Large for gestational age (HP:0001520)	1.82462353
84	Abnormality of alanine metabolism (HP:0010916)	1.81962064
85	Hyperalaninemia (HP:0003348)	1.81962064
86	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.81962064
87	Abnormality of macular pigmentation (HP:0008002)	1.80081684
88	Progressive cerebellar ataxia (HP:0002073)	1.79791620
89	Abnormal respiratory motile cilium morphology (HP:0005938)	1.78898014
90	Abnormal respiratory epithelium morphology (HP:0012253)	1.78898014
91	Stomach cancer (HP:0012126)	1.78629435
92	Volvulus (HP:0002580)	1.78217646
93	Constricted visual fields (HP:0001133)	1.76889356
94	Furrowed tongue (HP:0000221)	1.75137191
95	Abnormal mitochondria in muscle tissue (HP:0008316)	1.74574446
96	Congenital sensorineural hearing impairment (HP:0008527)	1.74536574
97	Ketoacidosis (HP:0001993)	1.73631429
98	Chorioretinal atrophy (HP:0000533)	1.72529075
99	Hemiparesis (HP:0001269)	1.72118577
100	Oligodactyly (hands) (HP:0001180)	1.72107786

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.25740794
2	MAP4K2	3.40892389
3	ADRBK2	2.70868699
4	NUAK1	2.64565073
5	TAOK3	2.52732271
6	WNK3	2.45318172
7	BMPR1B	2.43254477
8	GRK1	2.36523600
9	ACVR1B	2.30224563
10	ZAK	2.12859208
11	MAPK13	2.06913452
12	MAP3K4	1.96233122
13	WNK4	1.95191865
14	TXK	1.78857991
15	ERBB3	1.67379696
16	PINK1	1.63927584
17	TNIK	1.57711016
18	INSRR	1.56044070
19	CASK	1.53889931
20	TRIM28	1.50916213
21	TLK1	1.50249296
22	MKNK2	1.40482015
23	BCKDK	1.35876778
24	OXSR1	1.32729875
25	BCR	1.32692278
26	PAK3	1.23631717
27	CSNK1G2	1.22418735
28	MAP2K7	1.21516919
29	MARK1	1.20002674
30	DYRK2	1.18313052
31	PLK2	1.18102722
32	MKNK1	1.13500940
33	CSNK1G3	1.12465263
34	CSNK1A1L	1.10947152
35	STK38L	1.05856147
36	PRKCE	1.05153210
37	TIE1	1.04173635
38	CSNK1G1	1.03210125
39	DAPK2	0.96226174
40	MST4	0.94465256
41	TEC	0.93800226
42	PRKCG	0.93276916
43	STK39	0.92790083
44	NTRK3	0.88270713
45	ADRBK1	0.87581319
46	EPHA4	0.84261323
47	FGFR2	0.83756355
48	CDK19	0.77949221
49	PHKG1	0.74764356
50	PHKG2	0.74764356
51	TGFBR1	0.74119937
52	CAMKK2	0.69152774
53	STK3	0.66817704
54	PLK3	0.66075126
55	PTK2B	0.63646209
56	FER	0.62383951
57	AKT3	0.60697452
58	VRK1	0.56886908
59	SRPK1	0.55735641
60	PIK3CA	0.55372661
61	CAMK2A	0.55274474
62	ITK	0.55098357
63	IRAK1	0.54089609
64	MAPKAPK3	0.52089597
65	PRKCQ	0.49731115
66	DYRK3	0.48625875
67	STK16	0.48387596
68	PRKACA	0.47985626
69	RPS6KA4	0.47827655
70	PNCK	0.47093670
71	MAP2K6	0.45741498
72	EPHA3	0.45411817
73	NTRK2	0.45263252
74	FLT3	0.45051516
75	IKBKB	0.44502716
76	MAPKAPK5	0.44494509
77	CSNK1A1	0.43920497
78	BRSK2	0.41976653
79	EIF2AK3	0.41376500
80	PLK4	0.39484626
81	NEK1	0.39114824
82	OBSCN	0.38692765
83	RPS6KA5	0.38490868
84	STK11	0.37113933
85	CSNK1D	0.36065112
86	MINK1	0.35464212
87	PRKACB	0.35275744
88	STK24	0.34726805
89	PRKG1	0.34488801
90	PKN1	0.34156669
91	PRKCA	0.34148007
92	NME1	0.33831125
93	DYRK1A	0.31805560
94	CHUK	0.31643156
95	NLK	0.30715093
96	ERBB2	0.29808116
97	IGF1R	0.29780464
98	PRKAA1	0.29156183
99	HIPK2	0.28178542
100	CDK3	0.27824315

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.14460928
2	Phototransduction_Homo sapiens_hsa04744	2.88975908
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.85909857
4	Protein export_Homo sapiens_hsa03060	2.83689665
5	Butanoate metabolism_Homo sapiens_hsa00650	2.58068534
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.50097952
7	Nicotine addiction_Homo sapiens_hsa05033	2.36829942
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.32743382
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.24529616
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.20242625
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.00203028
12	Caffeine metabolism_Homo sapiens_hsa00232	1.97945460
13	Nitrogen metabolism_Homo sapiens_hsa00910	1.94156799
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.91146901
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.90690989
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.87968512
17	Propanoate metabolism_Homo sapiens_hsa00640	1.87872299
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.73923260
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.67811285
20	Basal transcription factors_Homo sapiens_hsa03022	1.65347984
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.53326609
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.52907442
23	Parkinsons disease_Homo sapiens_hsa05012	1.52347430
24	Homologous recombination_Homo sapiens_hsa03440	1.49210632
25	Taste transduction_Homo sapiens_hsa04742	1.48657848
26	Olfactory transduction_Homo sapiens_hsa04740	1.45098173
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.43982183
28	Morphine addiction_Homo sapiens_hsa05032	1.42644152
29	Peroxisome_Homo sapiens_hsa04146	1.24553184
30	Regulation of autophagy_Homo sapiens_hsa04140	1.20563322
31	Selenocompound metabolism_Homo sapiens_hsa00450	1.19689905
32	Chemical carcinogenesis_Homo sapiens_hsa05204	1.18540019
33	GABAergic synapse_Homo sapiens_hsa04727	1.18057139
34	RNA degradation_Homo sapiens_hsa03018	1.17149751
35	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.15662217
36	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.13077450
37	Cardiac muscle contraction_Homo sapiens_hsa04260	1.12965780
38	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.12654161
39	Circadian entrainment_Homo sapiens_hsa04713	1.12280132
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.10714572
41	Serotonergic synapse_Homo sapiens_hsa04726	1.09749298
42	Asthma_Homo sapiens_hsa05310	1.08244649
43	Glutamatergic synapse_Homo sapiens_hsa04724	1.05533244
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.04856512
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.04745968
46	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.98737506
47	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.98517167
48	Insulin secretion_Homo sapiens_hsa04911	0.97985409
49	Retinol metabolism_Homo sapiens_hsa00830	0.97533057
50	ABC transporters_Homo sapiens_hsa02010	0.96294888
51	Steroid biosynthesis_Homo sapiens_hsa00100	0.95740821
52	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.92765812
53	Huntingtons disease_Homo sapiens_hsa05016	0.91207412
54	Alzheimers disease_Homo sapiens_hsa05010	0.90690286
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.90550238
56	RNA polymerase_Homo sapiens_hsa03020	0.90549327
57	Primary immunodeficiency_Homo sapiens_hsa05340	0.87130516
58	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.85183542
59	Salivary secretion_Homo sapiens_hsa04970	0.84578070
60	Type I diabetes mellitus_Homo sapiens_hsa04940	0.80846652
61	Dopaminergic synapse_Homo sapiens_hsa04728	0.78564584
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.76956560
63	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.75180392
64	Collecting duct acid secretion_Homo sapiens_hsa04966	0.73539580
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.72815740
66	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.72815453
67	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.66578572
68	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.66326879
69	Sulfur metabolism_Homo sapiens_hsa00920	0.63782128
70	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.61686335
71	Non-homologous end-joining_Homo sapiens_hsa03450	0.60785837
72	Calcium signaling pathway_Homo sapiens_hsa04020	0.60518464
73	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.60340349
74	Proteasome_Homo sapiens_hsa03050	0.59125938
75	Metabolic pathways_Homo sapiens_hsa01100	0.58848266
76	Purine metabolism_Homo sapiens_hsa00230	0.58643416
77	Fat digestion and absorption_Homo sapiens_hsa04975	0.58314216
78	One carbon pool by folate_Homo sapiens_hsa00670	0.55727300
79	Circadian rhythm_Homo sapiens_hsa04710	0.55145237
80	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.54416429
81	Allograft rejection_Homo sapiens_hsa05330	0.53283065
82	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.52869169
83	Fatty acid elongation_Homo sapiens_hsa00062	0.52774668
84	Long-term depression_Homo sapiens_hsa04730	0.52503745
85	Glycerolipid metabolism_Homo sapiens_hsa00561	0.51436296
86	Graft-versus-host disease_Homo sapiens_hsa05332	0.51247406
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.50366168
88	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.49792186
89	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.48013623
90	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.47265472
91	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.43281590
92	Amphetamine addiction_Homo sapiens_hsa05031	0.42727879
93	Renin secretion_Homo sapiens_hsa04924	0.39703125
94	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.36090455
95	Histidine metabolism_Homo sapiens_hsa00340	0.35767479
96	Cocaine addiction_Homo sapiens_hsa05030	0.34385995
97	Cholinergic synapse_Homo sapiens_hsa04725	0.31675131
98	cAMP signaling pathway_Homo sapiens_hsa04024	0.31034707
99	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.30147775
100	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.30013464

OR4A14P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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