OR4A19P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of RNA splicing (GO:0033120)9.68941833
2seminiferous tubule development (GO:0072520)9.57508700
3negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)9.21527233
4cAMP biosynthetic process (GO:0006171)8.87528637
5detection of chemical stimulus involved in sensory perception (GO:0050907)8.46692284
6negative regulation of alpha-beta T cell differentiation (GO:0046639)8.38759628
7enteric nervous system development (GO:0048484)7.88584427
8regulation of protein sumoylation (GO:0033233)7.56331520
9synaptic transmission, dopaminergic (GO:0001963)7.06327769
10dendritic spine morphogenesis (GO:0060997)7.01298356
11positive regulation of mitochondrial fission (GO:0090141)7.00846061
12righting reflex (GO:0060013)6.96555057
13heterotypic cell-cell adhesion (GO:0034113)6.54952700
14positive regulation of T-helper 1 type immune response (GO:0002827)6.33363335
15detection of chemical stimulus (GO:0009593)6.09274322
16arachidonic acid secretion (GO:0050482)6.04823753
17icosanoid secretion (GO:0032309)6.04823753
18hepatocyte apoptotic process (GO:0097284)6.03201876
19endothelial cell differentiation (GO:0045446)5.96085041
20positive regulation of T-helper cell differentiation (GO:0045624)5.82486472
21phosphatidylinositol acyl-chain remodeling (GO:0036149)5.48254210
22drug transmembrane transport (GO:0006855)5.25926371
23regulation of mitochondrial fission (GO:0090140)5.15601365
24phosphatidylserine acyl-chain remodeling (GO:0036150)5.11449650
25neuronal ion channel clustering (GO:0045161)5.01873562
26icosanoid transport (GO:0071715)5.01359314
27fatty acid derivative transport (GO:1901571)5.01359314
28phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.00960004
29negative regulation of alpha-beta T cell activation (GO:0046636)4.87060476
30chemosensory behavior (GO:0007635)4.78753290
31hyaluronan catabolic process (GO:0030214)4.75969728
32neural tube formation (GO:0001841)4.73433149
33regulation of T-helper 1 type immune response (GO:0002825)4.56441938
34cilium or flagellum-dependent cell motility (GO:0001539)4.49527568
35embryonic digestive tract morphogenesis (GO:0048557)4.48505842
36positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.44187204
37cyclic purine nucleotide metabolic process (GO:0052652)4.43216499
38nephron epithelium morphogenesis (GO:0072088)4.37803770
39nephron tubule morphogenesis (GO:0072078)4.37803770
40vocalization behavior (GO:0071625)4.35121569
41ATP hydrolysis coupled proton transport (GO:0015991)4.33546429
42energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.33546429
43retina layer formation (GO:0010842)4.30411683
44cyclic nucleotide biosynthetic process (GO:0009190)4.28578885
45positive regulation of membrane potential (GO:0045838)4.27222785
46attachment of spindle microtubules to kinetochore (GO:0008608)4.24976940
47regulation of T-helper cell differentiation (GO:0045622)4.23634783
48cellular response to glucagon stimulus (GO:0071377)4.22770267
49response to dietary excess (GO:0002021)4.20215438
50regulation of type 2 immune response (GO:0002828)4.19963257
51negative regulation of actin filament bundle assembly (GO:0032232)4.19158735
52regulation of cAMP-mediated signaling (GO:0043949)4.19021033
53water transport (GO:0006833)4.10127523
54mitochondrial fusion (GO:0008053)4.04906475
55dendritic spine organization (GO:0097061)4.01275884
56cAMP metabolic process (GO:0046058)3.99632825
57protein localization to synapse (GO:0035418)3.97097627
58positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.90471428
59cytoskeletal anchoring at plasma membrane (GO:0007016)3.89975981
60negative regulation of cytosolic calcium ion concentration (GO:0051481)3.83241185
61cellular zinc ion homeostasis (GO:0006882)3.77276841
62monoamine transport (GO:0015844)3.71152859
63negative regulation of T cell differentiation (GO:0045581)3.70607899
64fluid transport (GO:0042044)3.66431133
65phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.60717205
66drug transport (GO:0015893)3.59836246
67leukotriene biosynthetic process (GO:0019370)3.59184396
68positive regulation of protein targeting to membrane (GO:0090314)3.56990715
69pre-miRNA processing (GO:0031054)3.51737994
70cellular response to ATP (GO:0071318)3.50978943
71sulfur amino acid catabolic process (GO:0000098)3.49559606
72sequestering of metal ion (GO:0051238)3.48198123
73negative regulation of homotypic cell-cell adhesion (GO:0034111)3.42383183
74positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.36090645
75positive regulation of alpha-beta T cell differentiation (GO:0046638)3.35068294
76regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.34021843
77left/right axis specification (GO:0070986)3.30825602
78negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.21320612
79response to glucagon (GO:0033762)3.15709449
80neuromuscular process controlling posture (GO:0050884)3.15553330
81renal tubule morphogenesis (GO:0061333)3.15157654
82positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.13973341
83neurofilament cytoskeleton organization (GO:0060052)3.12969698
84phosphatidylcholine acyl-chain remodeling (GO:0036151)3.12719296
85negative regulation of astrocyte differentiation (GO:0048712)3.10992913
86prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.10929941
87exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07732430
88adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.07018698
89adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.05514700
90positive regulation of steroid hormone secretion (GO:2000833)3.03381068
91tooth mineralization (GO:0034505)14.3925566
92detection of chemical stimulus involved in sensory perception of smell (GO:0050911)13.6391073
93positive regulation of protein sumoylation (GO:0033235)12.0049938
94negative regulation of T-helper cell differentiation (GO:0045623)11.4575432
95negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)11.4575432
96protein K11-linked deubiquitination (GO:0035871)10.6336760
97regulation of T-helper 1 cell differentiation (GO:0045625)10.3311015
98regulation of T-helper 2 cell differentiation (GO:0045628)10.1930229
99negative regulation of type 2 immune response (GO:0002829)10.1539523
100activation of protein kinase A activity (GO:0034199)10.1252262

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.58589653
2EGR1_19374776_ChIP-ChIP_THP-1_Human5.66227897
3IGF1R_20145208_ChIP-Seq_DFB_Human4.77295729
4AR_21572438_ChIP-Seq_LNCaP_Human4.74241632
5VDR_22108803_ChIP-Seq_LS180_Human4.19723200
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.53153332
7TP53_16413492_ChIP-PET_HCT116_Human2.15811513
8PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.03430822
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse10.7492386
10YY1_22570637_ChIP-Seq_MALME-3M_Human1.93176645
11ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.89465995
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88627951
13TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86055191
14POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.86055191
15GATA1_19941826_ChIP-Seq_K562_Human1.80468408
16NR3C1_23031785_ChIP-Seq_PC12_Mouse1.67255597
17DROSHA_22980978_ChIP-Seq_HELA_Human1.62216436
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59057770
19RNF2_27304074_Chip-Seq_ESCs_Mouse1.56770287
20EGR1_23403033_ChIP-Seq_LIVER_Mouse1.56249058
21EGR1_19032775_ChIP-ChIP_M12_Human1.56073506
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.51200494
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.47766773
24SMAD3_21741376_ChIP-Seq_HESCs_Human1.45899012
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.44265391
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42214913
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.37958708
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37703854
29SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32703798
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32241293
31SMAD3_21741376_ChIP-Seq_EPCs_Human1.32078017
32RXR_22108803_ChIP-Seq_LS180_Human1.25079961
33RNF2_27304074_Chip-Seq_NSC_Mouse1.24675934
34NANOG_18555785_Chip-Seq_ESCs_Mouse1.22509624
35TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.22035979
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19194994
37CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18465181
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15720582
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.12983134
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12805122
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12108382
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11640895
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08867752
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.08431442
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06865845
46HNFA_21074721_ChIP-Seq_CACO-2_Human1.05796419
47SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04368851
48SOX2_18555785_Chip-Seq_ESCs_Mouse1.03580629
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03304336
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.03226822
51GBX2_23144817_ChIP-Seq_PC3_Human1.02348852
52ER_23166858_ChIP-Seq_MCF-7_Human1.01677418
53EZH2_22144423_ChIP-Seq_EOC_Human1.01480250
54SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01163320
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00980967
56NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99343038
57GATA6_21074721_ChIP-Seq_CACO-2_Human0.99328875
58ARNT_22903824_ChIP-Seq_MCF-7_Human0.99086483
59PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99000033
60TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98048681
61PRDM14_20953172_ChIP-Seq_ESCs_Human0.97282993
62KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97179658
63SMAD4_21741376_ChIP-Seq_HESCs_Human0.96187403
64TBL1_22424771_ChIP-Seq_293T_Human0.95545174
65BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95173800
66CMYC_18555785_Chip-Seq_ESCs_Mouse0.95026974
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94686553
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.92575165
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91711575
70CJUN_26792858_Chip-Seq_BT549_Human0.91045207
71PHF8_20622853_ChIP-Seq_HELA_Human0.90155616
72SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89866855
73GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.89661887
74STAT3_23295773_ChIP-Seq_U87_Human0.89287573
75TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87629095
76NANOG_16518401_ChIP-PET_MESCs_Mouse0.86944696
77CTCF_27219007_Chip-Seq_Bcells_Human0.86190492
78BCAT_22108803_ChIP-Seq_LS180_Human0.86036551
79SUZ12_18555785_Chip-Seq_ESCs_Mouse0.84467655
80TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84441571
81CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.83544636
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83001947
83EZH2_18974828_ChIP-Seq_MESCs_Mouse0.82585261
84RNF2_18974828_ChIP-Seq_MESCs_Mouse0.82585261
85PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.81705101
86KLF4_18555785_Chip-Seq_ESCs_Mouse0.81116655
87NMYC_18555785_Chip-Seq_ESCs_Mouse0.81093338
88ETV2_25802403_ChIP-Seq_MESCs_Mouse0.80934085
89E2F1_18555785_Chip-Seq_ESCs_Mouse0.80913706
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.80565800
91REST_21632747_ChIP-Seq_MESCs_Mouse0.78990984
92GATA2_19941826_ChIP-Seq_K562_Human0.77129127
93RING1B_27294783_Chip-Seq_ESCs_Mouse0.76453236
94EZH2_27294783_Chip-Seq_NPCs_Mouse0.76071565
95FOXO3_23340844_ChIP-Seq_DLD1_Human0.74944118
96ISL1_27105846_Chip-Seq_CPCs_Mouse0.74484361
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.74403891
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73613961
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.73363256
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.73303932

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism9.75145426
2MP0004130_abnormal_muscle_cell5.00446336
3MP0004264_abnormal_extraembryonic_tissu4.02971328
4MP0003252_abnormal_bile_duct3.63032758
5MP0004133_heterotaxia2.83392277
6MP0002928_abnormal_bile_duct2.73321276
7MP0006072_abnormal_retinal_apoptosis2.44268641
8MP0005448_abnormal_energy_balance2.31027026
9MP0005408_hypopigmentation2.25091952
10MP0002751_abnormal_autonomic_nervous2.23419906
11MP0003329_amyloid_beta_deposits2.17468558
12MP0004272_abnormal_basement_membrane2.14549668
13MP0001270_distended_abdomen2.13092237
14MP0005084_abnormal_gallbladder_morpholo12.6776526
15MP0003943_abnormal_hepatobiliary_system1.76302561
16MP0005220_abnormal_exocrine_pancreas1.66481551
17MP0005379_endocrine/exocrine_gland_phen1.61304829
18MP0005165_increased_susceptibility_to1.58805445
19MP0009764_decreased_sensitivity_to1.45510090
20MP0001958_emphysema1.43621018
21MP0000604_amyloidosis1.39960168
22MP0001529_abnormal_vocalization1.32235337
23MP0003718_maternal_effect1.23637311
24MP0005646_abnormal_pituitary_gland1.08936718
25MP0000465_gastrointestinal_hemorrhage1.05150506
26MP0002909_abnormal_adrenal_gland1.01857010
27MP0000470_abnormal_stomach_morphology1.01332169
28MP0001905_abnormal_dopamine_level1.00532269
29MP0001944_abnormal_pancreas_morphology0.99313945
30MP0002572_abnormal_emotion/affect_behav0.96980845
31MP0008569_lethality_at_weaning0.93901531
32MP0003638_abnormal_response/metabolism_0.90578600
33MP0001915_intracranial_hemorrhage0.81097698
34MP0005164_abnormal_response_to0.80600469
35MP0008469_abnormal_protein_level0.79881807
36MP0000371_diluted_coat_color0.79024268
37MP0003121_genomic_imprinting0.78725807
38MP0001800_abnormal_humoral_immune0.76369345
39MP0004019_abnormal_vitamin_homeostasis0.75988262
40MP0002405_respiratory_system_inflammati0.75766396
41MP0000609_abnormal_liver_physiology0.72118389
42MP0002693_abnormal_pancreas_physiology0.72004475
43MP0003866_abnormal_defecation0.71417108
44MP0002098_abnormal_vibrissa_morphology0.68724532
45MP0008875_abnormal_xenobiotic_pharmacok0.66400874
46MP0000703_abnormal_thymus_morphology0.65179069
47MP0005253_abnormal_eye_physiology0.64651436
48MP0001851_eye_inflammation0.63586302
49MP0005387_immune_system_phenotype0.63379285
50MP0001790_abnormal_immune_system0.63379285
51MP0002136_abnormal_kidney_physiology0.63118207
52MP0004947_skin_inflammation0.63055725
53MP0002078_abnormal_glucose_homeostasis0.62719393
54MP0001533_abnormal_skeleton_physiology0.62558820
55MP0003953_abnormal_hormone_level0.60884313
56MP0002998_abnormal_bone_remodeling0.57791824
57MP0001845_abnormal_inflammatory_respons0.50727174
58MP0009642_abnormal_blood_homeostasis0.46870935
59MP0002722_abnormal_immune_system0.46136452
60MP0003195_calcinosis0.40965030
61MP0002822_catalepsy0.39626032
62MP0002419_abnormal_innate_immunity0.39525631
63MP0005334_abnormal_fat_pad0.39081381
64MP0005551_abnormal_eye_electrophysiolog0.38883686
65MP0000920_abnormal_myelination0.38293396
66MP0000759_abnormal_skeletal_muscle0.38114321
67MP0002429_abnormal_blood_cell0.37483915
68MP0000477_abnormal_intestine_morphology0.36640128
69MP0000598_abnormal_liver_morphology0.36148519
70MP0005365_abnormal_bile_salt0.35699110
71MP0004484_altered_response_of0.35380010
72MP0002452_abnormal_antigen_presenting0.34960172
73MP0009931_abnormal_skin_appearance0.34924623
74MP0005423_abnormal_somatic_nervous0.33876122
75MP0001299_abnormal_eye_distance/0.33500776
76MP0002882_abnormal_neuron_morphology0.33484587
77MP0008004_abnormal_stomach_pH0.32940466
78MP0001986_abnormal_taste_sensitivity0.32191113
79MP0005390_skeleton_phenotype0.32187101
80MP0001501_abnormal_sleep_pattern0.32017706
81MP0002420_abnormal_adaptive_immunity0.31459562
82MP0000716_abnormal_immune_system0.31141537
83MP0001819_abnormal_immune_cell0.30849736
84MP0002229_neurodegeneration0.30661540
85MP0001835_abnormal_antigen_presentation0.30156359
86MP0002398_abnormal_bone_marrow0.29255342
87MP0005395_other_phenotype0.28174758
88MP0002723_abnormal_immune_serum0.28171537
89MP0001175_abnormal_lung_morphology0.27742537
90MP0002735_abnormal_chemical_nociception0.27027445
91MP0005000_abnormal_immune_tolerance0.26197022
92MP0000689_abnormal_spleen_morphology0.23895860
93MP0009053_abnormal_anal_canal0.23451504
94MP0002066_abnormal_motor_capabilities/c0.22982088
95MP0002128_abnormal_blood_circulation0.21755177
96MP0003634_abnormal_glial_cell0.20924445
97MP0002396_abnormal_hematopoietic_system0.20265359
98MP0005391_vision/eye_phenotype0.20017549
99MP0000249_abnormal_blood_vessel0.19915683
100MP0002113_abnormal_skeleton_development0.19736273

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of dental color (HP:0011073)8.30707011
2Abnormality of renal resorption (HP:0011038)8.13182787
3Osteomalacia (HP:0002749)7.92945640
4Polyuria (HP:0000103)7.62855513
5Abnormality of the dental pulp (HP:0006479)7.60206697
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.81313498
7Abnormal urine output (HP:0012590)6.53244569
8Abnormality of renal excretion (HP:0011036)5.70343634
9Round ear (HP:0100830)5.51069217
10Chronic bronchitis (HP:0004469)4.94086921
11Volvulus (HP:0002580)4.31810057
12IgM deficiency (HP:0002850)4.25680352
13Lip pit (HP:0100267)4.24714146
14Autoimmune thrombocytopenia (HP:0001973)4.06322189
15Toxemia of pregnancy (HP:0100603)4.01263490
16Nephrocalcinosis (HP:0000121)3.90715076
17Esophageal varix (HP:0002040)3.88486142
18Abnormality of midbrain morphology (HP:0002418)3.81893318
19Molar tooth sign on MRI (HP:0002419)3.81893318
20Lipoatrophy (HP:0100578)3.44449663
21Sparse lateral eyebrow (HP:0005338)3.38187893
22Depressed nasal tip (HP:0000437)3.35643068
23Large earlobe (HP:0009748)3.32527484
24Abnormal respiratory motile cilium physiology (HP:0012261)3.27607496
25Rhinitis (HP:0012384)3.26047270
26Tachypnea (HP:0002789)3.23674662
27Drooling (HP:0002307)3.19185217
28Hypoparathyroidism (HP:0000829)3.15376430
29Intestinal fistula (HP:0100819)3.10463291
30Excessive salivation (HP:0003781)3.06557952
31Panhypogammaglobulinemia (HP:0003139)3.02430274
32Hyperphosphaturia (HP:0003109)2.88554705
33Personality changes (HP:0000751)2.88553750
34Thick eyebrow (HP:0000574)2.87527124
35Petechiae (HP:0000967)2.69789083
36Nephronophthisis (HP:0000090)2.62180565
37Ureteral stenosis (HP:0000071)2.58011415
38Hepatitis (HP:0012115)2.57110430
39Dilated cardiomyopathy (HP:0001644)2.56397965
40Abnormality of the fingertips (HP:0001211)2.46547830
41Short 5th finger (HP:0009237)2.44420235
42Abnormal urine phosphate concentration (HP:0012599)2.43857211
43Abnormal delayed hypersensitivity skin test (HP:0002963)2.39255329
44Ureteral obstruction (HP:0006000)2.37817263
45Chronic mucocutaneous candidiasis (HP:0002728)2.37503062
46Recurrent cutaneous fungal infections (HP:0011370)2.37503062
47Gingival overgrowth (HP:0000212)2.33727921
48Striae distensae (HP:0001065)2.33460261
49Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.33108063
50Glycosuria (HP:0003076)2.32441331
51Abnormality of urine glucose concentration (HP:0011016)2.32441331
52Abnormality of transition element cation homeostasis (HP:0011030)2.32230577
53Sudden cardiac death (HP:0001645)2.30761482
54Colitis (HP:0002583)2.27879440
55Nephropathy (HP:0000112)2.25144514
56Hypercalciuria (HP:0002150)2.23510847
57Preauricular pit (HP:0004467)2.17056470
58Periauricular skin pits (HP:0100277)2.17056470
59Inability to walk (HP:0002540)2.12755669
60Bronchitis (HP:0012387)2.12340998
61Decreased muscle mass (HP:0003199)2.11075459
62Recurrent otitis media (HP:0000403)2.10809716
63Agammaglobulinemia (HP:0004432)2.09457680
64Anal stenosis (HP:0002025)2.03202886
65Abnormality of salivation (HP:0100755)2.02762650
66Delayed eruption of teeth (HP:0000684)2.00352276
67Overgrowth (HP:0001548)12.3581309
68Amelogenesis imperfecta (HP:0000705)11.7342770
69Abnormality of calcium-phosphate metabolism (HP:0100530)10.1439088
70Chondrocalcinosis (HP:0000934)1.99780559
71Abnormality of the renal medulla (HP:0100957)1.95478501
72Abnormality of Sharpey fibers (HP:0100685)1.94948495
73Chorioretinal coloboma (HP:0000567)1.88507933
74Ectopic kidney (HP:0000086)1.86482531
75Truncal ataxia (HP:0002078)1.84472830
76Preauricular skin tag (HP:0000384)1.84138857
77Prominent supraorbital ridges (HP:0000336)1.81172032
78Renal tubular dysfunction (HP:0000124)1.78814063
79Stage 5 chronic kidney disease (HP:0003774)1.75410133
80Limited elbow extension (HP:0001377)1.75085010
81Abnormality of small intestinal villus morphology (HP:0011472)1.68994002
82Villous atrophy (HP:0011473)1.68994002
83Torticollis (HP:0000473)1.63857425
84Small hand (HP:0200055)1.60854942
85Palmoplantar keratoderma (HP:0000982)1.58383394
86Oculomotor apraxia (HP:0000657)1.58137917
87Ectropion (HP:0000656)1.57801324
88Polyneuropathy (HP:0001271)1.55762871
89Skin tags (HP:0010609)1.54768955
90Blepharitis (HP:0000498)1.53795399
91Prenatal maternal abnormality (HP:0002686)1.50429106
92Bronchiectasis (HP:0002110)1.49148089
93Viral hepatitis (HP:0006562)1.47418736
94Skin pits (HP:0100276)1.47299097
95Mask-like facies (HP:0000298)1.43783546
96Proximal placement of thumb (HP:0009623)1.42152375
97Inflammation of the large intestine (HP:0002037)1.41755114
98Highly arched eyebrow (HP:0002553)1.40333601
99Osteoarthritis (HP:0002758)1.39987066
100Aplasia/Hypoplasia of the earlobes (HP:0009906)1.29798120

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.66839866
2BLK4.36677084
3STK34.12309528
4RIPK43.22802879
5CDC42BPA2.19537733
6BMPR22.12094214
7NTRK214.2357703
8HIPK21.23782882
9FGFR10.92998548
10ROCK20.80911287
11INSRR0.67977200
12SYK0.67235294
13SRC0.64167694
14OBSCN0.59968156
15PRKCQ0.58804469
16PRKAA10.57643084
17ROCK10.55975734
18MUSK0.55787971
19MAP4K20.49340235
20GRK70.46403480
21PRKACG0.44243739
22WNK30.42682363
23ABL10.42428367
24TIE10.41845580
25TXK0.41100252
26MAPK150.40786978
27GRK10.40078204
28ADRBK20.37032314
29PRKACA0.36234119
30PRKACB0.35959287
31SRPK10.35436991
32CAMK2A0.31986548
33ERBB40.31432806
34PIK3CG0.29203314
35PLK10.25424461
36LYN0.25240882
37EPHA40.24085728
38MATK0.23769499
39PRKCA0.22527585
40MAPK140.22496191
41MST1R0.22362384
42GSK3B0.21710365
43TTN0.21444812
44LMTK20.21070180
45PLK40.20596119
46PRKCB0.20261107
47RPS6KA30.19937611
48DDR20.19388716
49KIT0.18800003
50KDR0.18712905
51FYN0.17942474
52PHKG20.17281178
53PHKG10.17281178
54GRK50.16781512
55TEC0.16291495
56EPHA20.16240886
57TLK10.15688825
58ITK0.14460683
59CSNK1A10.14370695
60CDK10.14361811
61PIM20.14030800
62PRKCD0.13665261
63CHUK0.12903282
64GRK60.11885770
65OXSR10.11313563
66WNK40.10746734
67PRKDC0.10358362
68MAPK90.10352300
69MAP2K60.10332850
70TNK20.10069828
71PKN10.09194153
72LCK0.09076380
73BTK0.08968105
74HCK0.08409984
75ADRBK10.08134986
76PRKCG0.08120426
77IGF1R0.07587264
78TAOK20.07076396
79EGFR0.06921223
80CAMK2G0.06726677
81ABL20.06292102
82AKT10.06180947
83TGFBR20.05381273
84PIM10.04987622
85NTRK10.04557651
86PRKG20.04418538
87INSR0.03826288
88STK390.03493240
89PRKCE0.03466581
90IKBKE0.03409978
91MYLK0.03341693
92PIK3CA0.03297377
93MOS0.02889072
94ZAK0.02634247
95MAP2K70.02587544
96PRKG10.02510827
97CAMK2B0.02109108
98MAPK40.02076216
99PINK10.01942378
100SGK10.01229096

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.26243923
2Sulfur relay system_Homo sapiens_hsa041223.75346395
3Sulfur metabolism_Homo sapiens_hsa009203.68769110
4Ovarian steroidogenesis_Homo sapiens_hsa049133.35341583
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.15547311
6Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.89259007
7Linoleic acid metabolism_Homo sapiens_hsa005912.88553885
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.74633098
9Collecting duct acid secretion_Homo sapiens_hsa049662.51888295
10Vibrio cholerae infection_Homo sapiens_hsa051102.41141999
11Bile secretion_Homo sapiens_hsa049762.38746941
12Thyroid hormone synthesis_Homo sapiens_hsa049182.23458642
13Pancreatic secretion_Homo sapiens_hsa049722.21532031
14Salivary secretion_Homo sapiens_hsa049702.13451550
15Fat digestion and absorption_Homo sapiens_hsa049752.11694627
16Gastric acid secretion_Homo sapiens_hsa049712.10821449
17Synaptic vesicle cycle_Homo sapiens_hsa047212.06059560
18Cocaine addiction_Homo sapiens_hsa050301.94148142
19Circadian entrainment_Homo sapiens_hsa047131.85019937
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83167708
21Insulin secretion_Homo sapiens_hsa049111.79803070
22Vascular smooth muscle contraction_Homo sapiens_hsa042701.75205224
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74916129
24Glutamatergic synapse_Homo sapiens_hsa047241.72646566
25Taste transduction_Homo sapiens_hsa047421.70736566
26GABAergic synapse_Homo sapiens_hsa047271.68734870
27Dilated cardiomyopathy_Homo sapiens_hsa054141.67588903
28Morphine addiction_Homo sapiens_hsa050321.67583597
29Longevity regulating pathway - mammal_Homo sapiens_hsa042111.64239384
30Ether lipid metabolism_Homo sapiens_hsa005651.59966541
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58704103
32Gap junction_Homo sapiens_hsa045401.55547912
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44470484
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.43790311
35Amphetamine addiction_Homo sapiens_hsa050311.40635736
36GnRH signaling pathway_Homo sapiens_hsa049121.38940221
37Melanogenesis_Homo sapiens_hsa049161.34380948
38Arachidonic acid metabolism_Homo sapiens_hsa005901.29326478
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28162890
40Oxytocin signaling pathway_Homo sapiens_hsa049211.17158420
41Platelet activation_Homo sapiens_hsa046111.16210786
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14330113
43Cholinergic synapse_Homo sapiens_hsa047251.14150643
44Estrogen signaling pathway_Homo sapiens_hsa049151.08465283
45Calcium signaling pathway_Homo sapiens_hsa040201.05612226
46Circadian rhythm_Homo sapiens_hsa047100.98336661
47Dorso-ventral axis formation_Homo sapiens_hsa043200.87583174
48Pyruvate metabolism_Homo sapiens_hsa006200.82186028
49Serotonergic synapse_Homo sapiens_hsa047260.76160251
50ECM-receptor interaction_Homo sapiens_hsa045120.74269362
51Oocyte meiosis_Homo sapiens_hsa041140.74024939
52Chemokine signaling pathway_Homo sapiens_hsa040620.72465893
53Rheumatoid arthritis_Homo sapiens_hsa053230.68631154
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64655497
55RNA degradation_Homo sapiens_hsa030180.53221381
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47866018
57cAMP signaling pathway_Homo sapiens_hsa040240.46365862
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.42879062
59Alcoholism_Homo sapiens_hsa050340.39663065
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39584991
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34362562
62Primary immunodeficiency_Homo sapiens_hsa053400.34143391
63Dopaminergic synapse_Homo sapiens_hsa047280.34138774
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.33130510
65Staphylococcus aureus infection_Homo sapiens_hsa051500.32617313
66Parkinsons disease_Homo sapiens_hsa050120.30952021
67Prion diseases_Homo sapiens_hsa050200.30620923
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.28729591
69Rap1 signaling pathway_Homo sapiens_hsa040150.24254360
70Purine metabolism_Homo sapiens_hsa002300.23192929
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.23002904
72Retinol metabolism_Homo sapiens_hsa008300.19761218
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.19697616
74Hedgehog signaling pathway_Homo sapiens_hsa043400.17861570
75Phagosome_Homo sapiens_hsa041450.15489291
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15460323
77Glucagon signaling pathway_Homo sapiens_hsa049220.14946282
78Tuberculosis_Homo sapiens_hsa051520.14176582
79Oxidative phosphorylation_Homo sapiens_hsa001900.14135926
80Systemic lupus erythematosus_Homo sapiens_hsa053220.13237207
81Ras signaling pathway_Homo sapiens_hsa040140.12111664
82Type I diabetes mellitus_Homo sapiens_hsa049400.11054080
83HTLV-I infection_Homo sapiens_hsa051660.10956726
84Caffeine metabolism_Homo sapiens_hsa002320.09938692
85African trypanosomiasis_Homo sapiens_hsa051430.09262162
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.08900213
87Leishmaniasis_Homo sapiens_hsa051400.08898311
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.07271640
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.06006114
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.05976377
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.05360089
92Renin secretion_Homo sapiens_hsa049240.04276369
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.03975131
94Hematopoietic cell lineage_Homo sapiens_hsa046400.03908932
95Chemical carcinogenesis_Homo sapiens_hsa052040.03727499
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.01893541
97Nicotine addiction_Homo sapiens_hsa050330.01786777
98Amoebiasis_Homo sapiens_hsa051460.01555931
99Asthma_Homo sapiens_hsa053100.00751024
100Autoimmune thyroid disease_Homo sapiens_hsa05320-0.0313126

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