OR4A4P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of RNA splicing (GO:0033120)9.79661488
2seminiferous tubule development (GO:0072520)9.67710249
3negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)9.31715245
4cAMP biosynthetic process (GO:0006171)8.96545335
5negative regulation of alpha-beta T cell differentiation (GO:0046639)8.47951042
6enteric nervous system development (GO:0048484)7.96803951
7regulation of protein sumoylation (GO:0033233)7.64963370
8synaptic transmission, dopaminergic (GO:0001963)7.13348437
9positive regulation of mitochondrial fission (GO:0090141)7.07748628
10dendritic spine morphogenesis (GO:0060997)7.07626988
11righting reflex (GO:0060013)7.02399360
12* detection of chemical stimulus involved in sensory perception (GO:0050907)6.97082504
13heterotypic cell-cell adhesion (GO:0034113)6.62016665
14positive regulation of T-helper 1 type immune response (GO:0002827)6.39729209
15arachidonic acid secretion (GO:0050482)6.10742045
16icosanoid secretion (GO:0032309)6.10742045
17hepatocyte apoptotic process (GO:0097284)6.09776559
18endothelial cell differentiation (GO:0045446)6.02071938
19positive regulation of T-helper cell differentiation (GO:0045624)5.88633205
20phosphatidylinositol acyl-chain remodeling (GO:0036149)5.52514122
21drug transmembrane transport (GO:0006855)5.31306243
22regulation of mitochondrial fission (GO:0090140)5.20548857
23phosphatidylserine acyl-chain remodeling (GO:0036150)5.15751252
24neuronal ion channel clustering (GO:0045161)5.07146810
25fatty acid derivative transport (GO:1901571)5.06236735
26icosanoid transport (GO:0071715)5.06236735
27phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.05237781
28* detection of chemical stimulus (GO:0009593)4.99997444
29negative regulation of alpha-beta T cell activation (GO:0046636)4.92544990
30chemosensory behavior (GO:0007635)4.83170586
31hyaluronan catabolic process (GO:0030214)4.81440417
32neural tube formation (GO:0001841)4.77782782
33regulation of T-helper 1 type immune response (GO:0002825)4.61113111
34embryonic digestive tract morphogenesis (GO:0048557)4.53345389
35cilium or flagellum-dependent cell motility (GO:0001539)4.51958126
36positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.48958899
37cyclic purine nucleotide metabolic process (GO:0052652)4.47755919
38nephron epithelium morphogenesis (GO:0072088)4.42659524
39nephron tubule morphogenesis (GO:0072078)4.42659524
40vocalization behavior (GO:0071625)4.38670643
41ATP hydrolysis coupled proton transport (GO:0015991)4.37940575
42energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.37940575
43retina layer formation (GO:0010842)4.34577374
44cyclic nucleotide biosynthetic process (GO:0009190)4.32951171
45positive regulation of membrane potential (GO:0045838)4.31070062
46attachment of spindle microtubules to kinetochore (GO:0008608)4.29602842
47regulation of T-helper cell differentiation (GO:0045622)4.28217386
48cellular response to glucagon stimulus (GO:0071377)4.27660401
49regulation of type 2 immune response (GO:0002828)4.24748016
50response to dietary excess (GO:0002021)4.24540673
51regulation of cAMP-mediated signaling (GO:0043949)4.23092885
52negative regulation of actin filament bundle assembly (GO:0032232)4.22977410
53water transport (GO:0006833)4.14553377
54mitochondrial fusion (GO:0008053)4.09624990
55dendritic spine organization (GO:0097061)4.05166738
56cAMP metabolic process (GO:0046058)4.03226171
57protein localization to synapse (GO:0035418)3.99475081
58positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.94729918
59cytoskeletal anchoring at plasma membrane (GO:0007016)3.93746126
60negative regulation of cytosolic calcium ion concentration (GO:0051481)3.86178728
61cellular zinc ion homeostasis (GO:0006882)3.81596131
62monoamine transport (GO:0015844)3.74761394
63negative regulation of T cell differentiation (GO:0045581)3.74629290
64fluid transport (GO:0042044)3.70427430
65phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.63758644
66drug transport (GO:0015893)3.63558833
67leukotriene biosynthetic process (GO:0019370)3.62128618
68positive regulation of protein targeting to membrane (GO:0090314)3.60869195
69pre-miRNA processing (GO:0031054)3.56017679
70cellular response to ATP (GO:0071318)3.54242045
71sulfur amino acid catabolic process (GO:0000098)3.53141771
72sequestering of metal ion (GO:0051238)3.52502495
73negative regulation of homotypic cell-cell adhesion (GO:0034111)3.46551344
74positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.39554864
75positive regulation of alpha-beta T cell differentiation (GO:0046638)3.38825402
76regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.37710899
77left/right axis specification (GO:0070986)3.34171784
78negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.25174940
79response to glucagon (GO:0033762)3.19550514
80renal tubule morphogenesis (GO:0061333)3.18646098
81neuromuscular process controlling posture (GO:0050884)3.18147350
82positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.16348443
83phosphatidylcholine acyl-chain remodeling (GO:0036151)3.15375790
84neurofilament cytoskeleton organization (GO:0060052)3.14434145
85negative regulation of astrocyte differentiation (GO:0048712)3.13843455
86prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.13599168
87exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11663601
88adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.09674797
89adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.08209680
90positive regulation of steroid hormone secretion (GO:2000833)3.06327900
91tooth mineralization (GO:0034505)14.5306132
92positive regulation of protein sumoylation (GO:0033235)12.1367214
93negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)11.5828178
94negative regulation of T-helper cell differentiation (GO:0045623)11.5828178
95* detection of chemical stimulus involved in sensory perception of smell (GO:0050911)11.2641939
96protein K11-linked deubiquitination (GO:0035871)10.7449146
97regulation of T-helper 1 cell differentiation (GO:0045625)10.4437149
98regulation of T-helper 2 cell differentiation (GO:0045628)10.3061175
99negative regulation of type 2 immune response (GO:0002829)10.2639986
100activation of protein kinase A activity (GO:0034199)10.2325912

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.60478367
2EGR1_19374776_ChIP-ChIP_THP-1_Human5.70130575
3IGF1R_20145208_ChIP-Seq_DFB_Human4.77294330
4AR_21572438_ChIP-Seq_LNCaP_Human4.74536478
5VDR_22108803_ChIP-Seq_LS180_Human4.18769818
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.54429733
7TP53_16413492_ChIP-PET_HCT116_Human2.16161581
8PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.03129096
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse10.7708851
10YY1_22570637_ChIP-Seq_MALME-3M_Human1.93750220
11ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.89300200
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88069441
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.86113744
14TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86113744
15GATA1_19941826_ChIP-Seq_K562_Human1.81345891
16NR3C1_23031785_ChIP-Seq_PC12_Mouse1.67373319
17DROSHA_22980978_ChIP-Seq_HELA_Human1.61234536
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57898920
19RNF2_27304074_Chip-Seq_ESCs_Mouse1.56613127
20EGR1_23403033_ChIP-Seq_LIVER_Mouse1.56459301
21EGR1_19032775_ChIP-ChIP_M12_Human1.56084620
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.50953211
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.48280750
24SMAD3_21741376_ChIP-Seq_HESCs_Human1.45624622
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.43617868
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41936314
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.37454372
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36769404
29SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32270328
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31572675
31SMAD3_21741376_ChIP-Seq_EPCs_Human1.31506948
32RNF2_27304074_Chip-Seq_NSC_Mouse1.24592802
33RXR_22108803_ChIP-Seq_LS180_Human1.24415912
34NANOG_18555785_Chip-Seq_ESCs_Mouse1.22367975
35TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.22151063
36CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18634848
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18530639
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15527659
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12532833
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.12474388
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11811263
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11290338
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09946655
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.07960292
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06502627
46HNFA_21074721_ChIP-Seq_CACO-2_Human1.05849625
47SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03741716
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03692032
49SOX2_18555785_Chip-Seq_ESCs_Mouse1.03542082
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.02968245
51ER_23166858_ChIP-Seq_MCF-7_Human1.01222124
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00681025
53GBX2_23144817_ChIP-Seq_PC3_Human1.00606200
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00493444
55NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99792866
56GATA6_21074721_ChIP-Seq_CACO-2_Human0.99458121
57EZH2_22144423_ChIP-Seq_EOC_Human0.99391367
58PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98876177
59ARNT_22903824_ChIP-Seq_MCF-7_Human0.98840922
60TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97681321
61KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97053894
62PRDM14_20953172_ChIP-Seq_ESCs_Human0.96885268
63SMAD4_21741376_ChIP-Seq_HESCs_Human0.95849632
64TBL1_22424771_ChIP-Seq_293T_Human0.95277871
65CMYC_18555785_Chip-Seq_ESCs_Mouse0.94972025
66BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94859035
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94589698
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.92621536
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91420776
70CJUN_26792858_Chip-Seq_BT549_Human0.90725085
71GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.90250546
72PHF8_20622853_ChIP-Seq_HELA_Human0.90008931
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89280864
74STAT3_23295773_ChIP-Seq_U87_Human0.88524129
75TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87565985
76NANOG_16518401_ChIP-PET_MESCs_Mouse0.87403917
77CTCF_27219007_Chip-Seq_Bcells_Human0.86430090
78BCAT_22108803_ChIP-Seq_LS180_Human0.85535349
79TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84455249
80SUZ12_18555785_Chip-Seq_ESCs_Mouse0.84367897
81CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.83490558
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.82827174
83RNF2_18974828_ChIP-Seq_MESCs_Mouse0.82198266
84EZH2_18974828_ChIP-Seq_MESCs_Mouse0.82198266
85PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.81579770
86NMYC_18555785_Chip-Seq_ESCs_Mouse0.81049427
87KLF4_18555785_Chip-Seq_ESCs_Mouse0.81012079
88ETV2_25802403_ChIP-Seq_MESCs_Mouse0.80895233
89E2F1_18555785_Chip-Seq_ESCs_Mouse0.80704312
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.80151112
91REST_21632747_ChIP-Seq_MESCs_Mouse0.78284711
92GATA2_19941826_ChIP-Seq_K562_Human0.77524970
93RING1B_27294783_Chip-Seq_ESCs_Mouse0.76368519
94EZH2_27294783_Chip-Seq_NPCs_Mouse0.75668563
95FOXO3_23340844_ChIP-Seq_DLD1_Human0.75431373
96ISL1_27105846_Chip-Seq_CPCs_Mouse0.74861375
97SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.74241006
98KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.74153083
99KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.74153083
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.74153083

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism9.75473862
2MP0004130_abnormal_muscle_cell5.00251719
3MP0004264_abnormal_extraembryonic_tissu4.02899570
4MP0003252_abnormal_bile_duct3.62990725
5MP0004133_heterotaxia2.83864157
6MP0002928_abnormal_bile_duct2.72768117
7MP0006072_abnormal_retinal_apoptosis2.44453679
8MP0005448_abnormal_energy_balance2.30799653
9MP0005408_hypopigmentation2.25363808
10MP0002751_abnormal_autonomic_nervous2.23644717
11MP0003329_amyloid_beta_deposits2.17966428
12MP0004272_abnormal_basement_membrane2.15091963
13MP0001270_distended_abdomen2.13354923
14MP0005084_abnormal_gallbladder_morpholo12.6849972
15MP0003943_abnormal_hepatobiliary_system1.75994324
16MP0005220_abnormal_exocrine_pancreas1.66538433
17MP0005379_endocrine/exocrine_gland_phen1.61191084
18MP0005165_increased_susceptibility_to1.59233450
19MP0009764_decreased_sensitivity_to1.45592842
20MP0001958_emphysema1.43883347
21MP0000604_amyloidosis1.40335244
22MP0001529_abnormal_vocalization1.32329181
23MP0003718_maternal_effect1.23713518
24MP0005646_abnormal_pituitary_gland1.08620861
25MP0000465_gastrointestinal_hemorrhage1.03745558
26MP0002909_abnormal_adrenal_gland1.02131336
27MP0000470_abnormal_stomach_morphology1.01150821
28MP0001905_abnormal_dopamine_level0.99867687
29MP0001944_abnormal_pancreas_morphology0.99259152
30MP0002572_abnormal_emotion/affect_behav0.96220074
31MP0008569_lethality_at_weaning0.93692363
32MP0003638_abnormal_response/metabolism_0.90449034
33MP0001915_intracranial_hemorrhage0.81942052
34MP0005164_abnormal_response_to0.81121454
35MP0008469_abnormal_protein_level0.80013609
36MP0003121_genomic_imprinting0.79391006
37MP0000371_diluted_coat_color0.78875520
38MP0001800_abnormal_humoral_immune0.76676124
39MP0002405_respiratory_system_inflammati0.75678712
40MP0004019_abnormal_vitamin_homeostasis0.74828686
41MP0000609_abnormal_liver_physiology0.72132377
42MP0002693_abnormal_pancreas_physiology0.71743187
43MP0003866_abnormal_defecation0.71522612
44MP0002098_abnormal_vibrissa_morphology0.69054797
45MP0008875_abnormal_xenobiotic_pharmacok0.66711310
46MP0000703_abnormal_thymus_morphology0.65718312
47MP0005253_abnormal_eye_physiology0.64398042
48MP0001851_eye_inflammation0.63959921
49MP0001790_abnormal_immune_system0.63706198
50MP0005387_immune_system_phenotype0.63706198
51MP0004947_skin_inflammation0.63402690
52MP0002136_abnormal_kidney_physiology0.62983551
53MP0001533_abnormal_skeleton_physiology0.62976983
54MP0002078_abnormal_glucose_homeostasis0.62604477
55MP0003953_abnormal_hormone_level0.60605908
56MP0002998_abnormal_bone_remodeling0.58079658
57MP0001845_abnormal_inflammatory_respons0.50957516
58MP0009642_abnormal_blood_homeostasis0.46858474
59MP0002722_abnormal_immune_system0.46423564
60MP0002419_abnormal_innate_immunity0.39875492
61MP0002822_catalepsy0.39699674
62MP0003195_calcinosis0.39398192
63MP0005334_abnormal_fat_pad0.38979623
64MP0000759_abnormal_skeletal_muscle0.38266102
65MP0000920_abnormal_myelination0.38006259
66MP0002429_abnormal_blood_cell0.37787076
67MP0005551_abnormal_eye_electrophysiolog0.37648930
68MP0000477_abnormal_intestine_morphology0.36879776
69MP0000598_abnormal_liver_morphology0.36183626
70MP0005365_abnormal_bile_salt0.35645517
71MP0004484_altered_response_of0.35422126
72MP0002452_abnormal_antigen_presenting0.35280425
73MP0009931_abnormal_skin_appearance0.35236830
74MP0001299_abnormal_eye_distance/0.33957013
75MP0002882_abnormal_neuron_morphology0.33097996
76MP0005423_abnormal_somatic_nervous0.33058772
77MP0008004_abnormal_stomach_pH0.32509307
78MP0005390_skeleton_phenotype0.32490260
79MP0001986_abnormal_taste_sensitivity0.31872182
80MP0002420_abnormal_adaptive_immunity0.31783630
81MP0000716_abnormal_immune_system0.31408644
82MP0001819_abnormal_immune_cell0.31167883
83MP0001835_abnormal_antigen_presentation0.30782978
84MP0001501_abnormal_sleep_pattern0.30632634
85MP0002229_neurodegeneration0.30033623
86MP0002398_abnormal_bone_marrow0.29600901
87MP0002723_abnormal_immune_serum0.28394560
88MP0005395_other_phenotype0.27983587
89MP0001175_abnormal_lung_morphology0.27931042
90MP0005000_abnormal_immune_tolerance0.26655115
91MP0002735_abnormal_chemical_nociception0.26639432
92MP0000689_abnormal_spleen_morphology0.24104579
93MP0009053_abnormal_anal_canal0.23483381
94MP0002066_abnormal_motor_capabilities/c0.22710023
95MP0002128_abnormal_blood_circulation0.21951036
96MP0003634_abnormal_glial_cell0.20861639
97MP0002396_abnormal_hematopoietic_system0.20414350
98MP0005391_vision/eye_phenotype0.20165152
99MP0000249_abnormal_blood_vessel0.20129594
100MP0002113_abnormal_skeleton_development0.19801102

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of dental color (HP:0011073)8.30367501
2Abnormality of renal resorption (HP:0011038)8.14109759
3Osteomalacia (HP:0002749)7.93736342
4Polyuria (HP:0000103)7.61869831
5Abnormality of the dental pulp (HP:0006479)7.60284897
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.81196721
7Abnormal urine output (HP:0012590)6.52490758
8Abnormality of renal excretion (HP:0011036)5.69536118
9Round ear (HP:0100830)5.51876030
10Chronic bronchitis (HP:0004469)4.94305399
11Volvulus (HP:0002580)4.32503204
12IgM deficiency (HP:0002850)4.26752645
13Lip pit (HP:0100267)4.24102998
14Autoimmune thrombocytopenia (HP:0001973)4.06415852
15Toxemia of pregnancy (HP:0100603)4.01475675
16Nephrocalcinosis (HP:0000121)3.91154710
17Esophageal varix (HP:0002040)3.87835131
18Molar tooth sign on MRI (HP:0002419)3.80256639
19Abnormality of midbrain morphology (HP:0002418)3.80256639
20Lipoatrophy (HP:0100578)3.45010622
21Sparse lateral eyebrow (HP:0005338)3.39376546
22Depressed nasal tip (HP:0000437)3.36215987
23Large earlobe (HP:0009748)3.33078055
24Abnormal respiratory motile cilium physiology (HP:0012261)3.26714984
25Rhinitis (HP:0012384)3.25842380
26Tachypnea (HP:0002789)3.24288998
27Drooling (HP:0002307)3.19368645
28Hypoparathyroidism (HP:0000829)3.15914349
29Intestinal fistula (HP:0100819)3.10714354
30Excessive salivation (HP:0003781)3.06772887
31Panhypogammaglobulinemia (HP:0003139)3.03167886
32Personality changes (HP:0000751)2.89512152
33Hyperphosphaturia (HP:0003109)2.89194259
34Thick eyebrow (HP:0000574)2.86895437
35Petechiae (HP:0000967)2.70335358
36Nephronophthisis (HP:0000090)2.61560731
37Ureteral stenosis (HP:0000071)2.58071054
38Hepatitis (HP:0012115)2.57792974
39Dilated cardiomyopathy (HP:0001644)2.56890091
40Abnormality of the fingertips (HP:0001211)2.47474990
41Abnormal urine phosphate concentration (HP:0012599)2.44371421
42Short 5th finger (HP:0009237)2.44198200
43Abnormal delayed hypersensitivity skin test (HP:0002963)2.39566415
44Ureteral obstruction (HP:0006000)2.37936105
45Chronic mucocutaneous candidiasis (HP:0002728)2.37867693
46Recurrent cutaneous fungal infections (HP:0011370)2.37867693
47Striae distensae (HP:0001065)2.33552709
48Gingival overgrowth (HP:0000212)2.33403793
49Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.32827376
50Abnormality of urine glucose concentration (HP:0011016)2.32636845
51Glycosuria (HP:0003076)2.32636845
52Abnormality of transition element cation homeostasis (HP:0011030)2.32374743
53Sudden cardiac death (HP:0001645)2.31353377
54Colitis (HP:0002583)2.28593210
55Nephropathy (HP:0000112)2.25355575
56Hypercalciuria (HP:0002150)2.23587015
57Preauricular pit (HP:0004467)2.16137735
58Periauricular skin pits (HP:0100277)2.16137735
59Bronchitis (HP:0012387)2.12377868
60Inability to walk (HP:0002540)2.11558829
61Decreased muscle mass (HP:0003199)2.11293183
62Recurrent otitis media (HP:0000403)2.11240735
63Agammaglobulinemia (HP:0004432)2.10108437
64Anal stenosis (HP:0002025)2.03434434
65Abnormality of salivation (HP:0100755)2.02887076
66Delayed eruption of teeth (HP:0000684)2.00776445
67Chondrocalcinosis (HP:0000934)2.00442268
68Overgrowth (HP:0001548)12.3690175
69Amelogenesis imperfecta (HP:0000705)11.7331950
70Abnormality of calcium-phosphate metabolism (HP:0100530)10.1542570
71Abnormality of Sharpey fibers (HP:0100685)1.95589071
72Abnormality of the renal medulla (HP:0100957)1.94610563
73Chorioretinal coloboma (HP:0000567)1.88530604
74Ectopic kidney (HP:0000086)1.87169594
75Truncal ataxia (HP:0002078)1.84593438
76Preauricular skin tag (HP:0000384)1.84503762
77Prominent supraorbital ridges (HP:0000336)1.81183610
78Renal tubular dysfunction (HP:0000124)1.79348735
79Limited elbow extension (HP:0001377)1.75770981
80Stage 5 chronic kidney disease (HP:0003774)1.75298608
81Abnormality of small intestinal villus morphology (HP:0011472)1.69948075
82Villous atrophy (HP:0011473)1.69948075
83Torticollis (HP:0000473)1.63962831
84Palmoplantar keratoderma (HP:0000982)1.58532314
85Small hand (HP:0200055)1.58318661
86Ectropion (HP:0000656)1.58275807
87Oculomotor apraxia (HP:0000657)1.57709592
88Polyneuropathy (HP:0001271)1.55738652
89Skin tags (HP:0010609)1.55149666
90Blepharitis (HP:0000498)1.54210130
91Prenatal maternal abnormality (HP:0002686)1.50588447
92Bronchiectasis (HP:0002110)1.48787093
93Viral hepatitis (HP:0006562)1.48201178
94Skin pits (HP:0100276)1.46459440
95Mask-like facies (HP:0000298)1.44359600
96Inflammation of the large intestine (HP:0002037)1.42009400
97Proximal placement of thumb (HP:0009623)1.41356381
98Osteoarthritis (HP:0002758)1.40407905
99Highly arched eyebrow (HP:0002553)1.39815930
100Aplasia/Hypoplasia of the earlobes (HP:0009906)1.30042748

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.67441394
2BLK4.36844559
3STK34.10934916
4RIPK43.23127349
5CDC42BPA2.19931315
6BMPR22.12305098
7NTRK214.2441691
8HIPK21.24160324
9FGFR10.93311877
10ROCK20.81163818
11SYK0.67373407
12SRC0.64196885
13OBSCN0.59906509
14INSRR0.58983544
15PRKCQ0.58751030
16PRKAA10.57598407
17ROCK10.56136583
18MUSK0.55395710
19MAP4K20.49446269
20GRK70.46478607
21PRKACG0.44125883
22ABL10.42487239
23WNK30.42149353
24TIE10.41617125
25TXK0.40986546
26MAPK150.40885548
27GRK10.39930662
28SRPK10.36485545
29ADRBK20.36093256
30PRKACA0.36050014
31PRKACB0.35764277
32CAMK2A0.31622559
33ERBB40.31602829
34PIK3CG0.29021367
35PLK10.25628159
36LYN0.25354073
37EPHA40.24233269
38MATK0.23709804
39MAPK140.22527401
40MST1R0.22415315
41PRKCA0.22361438
42TTN0.21857897
43GSK3B0.21635887
44LMTK20.21189527
45PLK40.20728626
46PRKCB0.20084631
47RPS6KA30.19761999
48DDR20.19344565
49KIT0.18396855
50KDR0.18099052
51FYN0.17949318
52PHKG20.17063026
53PHKG10.17063026
54GRK50.16733011
55EPHA20.16572994
56TEC0.16237557
57TLK10.15711564
58PIM20.14445729
59CDK10.14360384
60ITK0.14345072
61CSNK1A10.14289125
62PRKCD0.13673692
63CHUK0.12986995
64GRK60.12181606
65WNK40.10947070
66OXSR10.10920412
67PRKDC0.10481030
68MAPK90.10440511
69MAP2K60.10104768
70TNK20.09619110
71BTK0.09246558
72LCK0.09114659
73PKN10.08743833
74HCK0.08272785
75ADRBK10.07655696
76IGF1R0.07587772
77PRKCG0.07546827
78TAOK20.07037122
79EGFR0.07006100
80CAMK2G0.06683735
81ABL20.06255870
82AKT10.06186335
83TGFBR20.05783791
84PIM10.05106611
85NTRK10.04593269
86PRKG20.04235807
87INSR0.03788587
88IKBKE0.03604469
89MOS0.03319073
90STK390.03281285
91PIK3CA0.03233707
92PRKCE0.03193989
93MYLK0.03095428
94ZAK0.02790213
95MAP2K70.02589424
96PRKG10.02332528
97CAMK2B0.01907706
98MAPK40.01891755
99PINK10.01586848
100SGK10.01219971

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.26439142
2Sulfur relay system_Homo sapiens_hsa041223.76059026
3Sulfur metabolism_Homo sapiens_hsa009203.69432815
4Ovarian steroidogenesis_Homo sapiens_hsa049133.35416314
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.15055681
6Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.89866859
7Linoleic acid metabolism_Homo sapiens_hsa005912.88111374
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.75041826
9Collecting duct acid secretion_Homo sapiens_hsa049662.52135312
10Vibrio cholerae infection_Homo sapiens_hsa051102.41733000
11Bile secretion_Homo sapiens_hsa049762.38786374
12Thyroid hormone synthesis_Homo sapiens_hsa049182.23795628
13Pancreatic secretion_Homo sapiens_hsa049722.21579410
14Salivary secretion_Homo sapiens_hsa049702.13249232
15Fat digestion and absorption_Homo sapiens_hsa049752.11726294
16Gastric acid secretion_Homo sapiens_hsa049712.10642141
17Synaptic vesicle cycle_Homo sapiens_hsa047212.06067885
18Cocaine addiction_Homo sapiens_hsa050301.94133791
19Circadian entrainment_Homo sapiens_hsa047131.84641039
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83305966
21Insulin secretion_Homo sapiens_hsa049111.79514094
22Vascular smooth muscle contraction_Homo sapiens_hsa042701.74983556
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74766498
24Glutamatergic synapse_Homo sapiens_hsa047241.72187943
25Taste transduction_Homo sapiens_hsa047421.69971548
26GABAergic synapse_Homo sapiens_hsa047271.68395615
27Dilated cardiomyopathy_Homo sapiens_hsa054141.67644941
28Morphine addiction_Homo sapiens_hsa050321.67048391
29Longevity regulating pathway - mammal_Homo sapiens_hsa042111.64642713
30Ether lipid metabolism_Homo sapiens_hsa005651.59525453
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.59443744
32Gap junction_Homo sapiens_hsa045401.55886417
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44021195
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.43899719
35Amphetamine addiction_Homo sapiens_hsa050311.40559746
36GnRH signaling pathway_Homo sapiens_hsa049121.39151423
37Melanogenesis_Homo sapiens_hsa049161.34696752
38Arachidonic acid metabolism_Homo sapiens_hsa005901.28800421
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28280654
40Oxytocin signaling pathway_Homo sapiens_hsa049211.16946413
41Platelet activation_Homo sapiens_hsa046111.16400867
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14652516
43Cholinergic synapse_Homo sapiens_hsa047251.13912872
44Estrogen signaling pathway_Homo sapiens_hsa049151.08577519
45Calcium signaling pathway_Homo sapiens_hsa040201.05166255
46Circadian rhythm_Homo sapiens_hsa047100.98516704
47Dorso-ventral axis formation_Homo sapiens_hsa043200.87623192
48Pyruvate metabolism_Homo sapiens_hsa006200.82752205
49Serotonergic synapse_Homo sapiens_hsa047260.75562352
50Oocyte meiosis_Homo sapiens_hsa041140.74408615
51ECM-receptor interaction_Homo sapiens_hsa045120.74251818
52Chemokine signaling pathway_Homo sapiens_hsa040620.72618530
53Rheumatoid arthritis_Homo sapiens_hsa053230.68748313
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64685179
55RNA degradation_Homo sapiens_hsa030180.53889426
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47999755
57cAMP signaling pathway_Homo sapiens_hsa040240.45973454
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.42711878
59Alcoholism_Homo sapiens_hsa050340.39908444
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39374589
61Primary immunodeficiency_Homo sapiens_hsa053400.34425260
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34275761
63Dopaminergic synapse_Homo sapiens_hsa047280.33934711
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.32979390
65Staphylococcus aureus infection_Homo sapiens_hsa051500.32783936
66Parkinsons disease_Homo sapiens_hsa050120.31623104
67Prion diseases_Homo sapiens_hsa050200.31146244
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.28931372
69Rap1 signaling pathway_Homo sapiens_hsa040150.24160478
70Purine metabolism_Homo sapiens_hsa002300.22985683
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.22574399
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.19674172
73Retinol metabolism_Homo sapiens_hsa008300.19123485
74Hedgehog signaling pathway_Homo sapiens_hsa043400.18001008
75Phagosome_Homo sapiens_hsa041450.15613235
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15412008
77Glucagon signaling pathway_Homo sapiens_hsa049220.15105512
78Oxidative phosphorylation_Homo sapiens_hsa001900.14602414
79Tuberculosis_Homo sapiens_hsa051520.14385800
80Systemic lupus erythematosus_Homo sapiens_hsa053220.13449577
81Ras signaling pathway_Homo sapiens_hsa040140.11836909
82HTLV-I infection_Homo sapiens_hsa051660.11187729
83Type I diabetes mellitus_Homo sapiens_hsa049400.11185925
84Caffeine metabolism_Homo sapiens_hsa002320.09918589
85Leishmaniasis_Homo sapiens_hsa051400.09286822
86African trypanosomiasis_Homo sapiens_hsa051430.09261036
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.08471569
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.06874534
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.06302548
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.05767029
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.05574852
92Hematopoietic cell lineage_Homo sapiens_hsa046400.04078648
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.04013451
94Renin secretion_Homo sapiens_hsa049240.03804639
95Chemical carcinogenesis_Homo sapiens_hsa052040.03446688
96Amoebiasis_Homo sapiens_hsa051460.01753446
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.00978569
98Asthma_Homo sapiens_hsa053100.00806935
99Nicotine addiction_Homo sapiens_hsa050330.00628669
100Autoimmune thyroid disease_Homo sapiens_hsa05320-0.0300555

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