ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.78462269
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.69119598
3	epithelial cilium movement (GO:0003351)	4.35483334
4	ATP synthesis coupled proton transport (GO:0015986)	4.32756261
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.32756261
6	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.12017816
7	axonemal dynein complex assembly (GO:0070286)	4.06767909
8	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.91671955
9	hindbrain development (GO:0030902)	3.87733820
10	cilium movement (GO:0003341)	3.71393956
11	electron transport chain (GO:0022900)	3.62436417
12	respiratory electron transport chain (GO:0022904)	3.56602868
13	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.51586221
14	postsynaptic membrane organization (GO:0001941)	3.48861676
15	sequestering of actin monomers (GO:0042989)	3.48631780
16	neuronal action potential (GO:0019228)	3.43295106
17	protein complex biogenesis (GO:0070271)	3.31723202
18	positive regulation of gastrulation (GO:2000543)	3.29997114
19	dopamine biosynthetic process (GO:0042416)	3.27134460
20	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.26051977
21	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.26051977
22	NADH dehydrogenase complex assembly (GO:0010257)	3.26051977
23	regulation of action potential (GO:0098900)	3.13186007
24	protein localization to synapse (GO:0035418)	3.12941999
25	DNA deamination (GO:0045006)	3.09974551
26	mitochondrial respiratory chain complex assembly (GO:0033108)	3.08228803
27	indolalkylamine metabolic process (GO:0006586)	3.06733157
28	nonmotile primary cilium assembly (GO:0035058)	3.01959965
29	presynaptic membrane assembly (GO:0097105)	3.00884550
30	cilium or flagellum-dependent cell motility (GO:0001539)	3.00330337
31	viral transcription (GO:0019083)	2.97399862
32	cellular response to nicotine (GO:0071316)	2.94014968
33	synaptic transmission, cholinergic (GO:0007271)	2.92934203
34	regulation of cilium movement (GO:0003352)	2.92599463
35	auditory behavior (GO:0031223)	2.92177214
36	translational termination (GO:0006415)	2.91825360
37	neuron fate determination (GO:0048664)	2.90713873
38	protein polyglutamylation (GO:0018095)	2.90222336
39	kynurenine metabolic process (GO:0070189)	2.88617921
40	cilium morphogenesis (GO:0060271)	2.87364667
41	regulation of dopamine secretion (GO:0014059)	2.85911160
42	protein-cofactor linkage (GO:0018065)	2.82855342
43	intracellular protein transmembrane import (GO:0044743)	2.82377139
44	water-soluble vitamin biosynthetic process (GO:0042364)	2.79940539
45	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.79879602
46	cytidine deamination (GO:0009972)	2.79029068
47	cytidine metabolic process (GO:0046087)	2.79029068
48	cytidine catabolic process (GO:0006216)	2.79029068
49	somite rostral/caudal axis specification (GO:0032525)	2.78604590
50	tryptophan catabolic process (GO:0006569)	2.78117722
51	indole-containing compound catabolic process (GO:0042436)	2.78117722
52	indolalkylamine catabolic process (GO:0046218)	2.78117722
53	hydrogen ion transmembrane transport (GO:1902600)	2.77719695
54	transmission of nerve impulse (GO:0019226)	2.77447618
55	kidney morphogenesis (GO:0060993)	2.77392061
56	neural tube formation (GO:0001841)	2.75504923
57	fucose catabolic process (GO:0019317)	2.74604124
58	L-fucose metabolic process (GO:0042354)	2.74604124
59	L-fucose catabolic process (GO:0042355)	2.74604124
60	negative regulation of mast cell activation (GO:0033004)	2.74328586
61	sulfation (GO:0051923)	2.74249858
62	dopamine transport (GO:0015872)	2.71892753
63	platelet dense granule organization (GO:0060155)	2.71520496
64	response to pheromone (GO:0019236)	2.67083030
65	spinal cord motor neuron differentiation (GO:0021522)	2.66292055
66	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.65312033
67	proton transport (GO:0015992)	2.64969711
68	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.62386989
69	cilium organization (GO:0044782)	2.61316669
70	indole-containing compound metabolic process (GO:0042430)	2.60402113
71	axoneme assembly (GO:0035082)	2.60277800
72	pyrimidine nucleobase catabolic process (GO:0006208)	2.59832828
73	hydrogen transport (GO:0006818)	2.59196218
74	membrane depolarization during action potential (GO:0086010)	2.58775330
75	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.58702578
76	midbrain development (GO:0030901)	2.56467892
77	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.55997121
78	serotonin metabolic process (GO:0042428)	2.55633639
79	cilium assembly (GO:0042384)	2.55202910
80	protein neddylation (GO:0045116)	2.54227662
81	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.52991187
82	determination of left/right symmetry (GO:0007368)	2.52842962
83	GTP biosynthetic process (GO:0006183)	2.51818909
84	protein import into peroxisome matrix (GO:0016558)	2.51572425
85	gamma-aminobutyric acid transport (GO:0015812)	2.51490624
86	tryptophan metabolic process (GO:0006568)	2.51049069
87	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.49718202
88	positive regulation of meiosis (GO:0045836)	2.49158681
89	presynaptic membrane organization (GO:0097090)	2.48251966
90	primary amino compound metabolic process (GO:1901160)	2.47086904
91	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.46704940
92	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.45677800
93	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.45096318
94	ATP biosynthetic process (GO:0006754)	2.45090003
95	spinal cord development (GO:0021510)	2.44686098
96	negative regulation of telomere maintenance (GO:0032205)	2.44385928
97	nephron epithelium morphogenesis (GO:0072088)	2.43817847
98	nephron tubule morphogenesis (GO:0072078)	2.43817847
99	regulation of microtubule-based movement (GO:0060632)	2.43753834
100	mechanosensory behavior (GO:0007638)	2.42096413

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.10007982
2	VDR_22108803_ChIP-Seq_LS180_Human	3.24377294
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.19221880
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.00280701
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.81474874
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.73431179
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.34052618
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.29757241
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.29102295
10	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.27169844
11	P300_19829295_ChIP-Seq_ESCs_Human	2.01687442
12	FUS_26573619_Chip-Seq_HEK293_Human	2.01609663
13	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.99232041
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.95813135
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.94956688
16	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.91508752
17	EWS_26573619_Chip-Seq_HEK293_Human	1.91219834
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.88893825
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.85893475
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.78455766
21	IGF1R_20145208_ChIP-Seq_DFB_Human	1.76990215
22	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.73168698
23	REST_21632747_ChIP-Seq_MESCs_Mouse	1.69988990
24	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.67401784
25	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.66941355
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.66637805
27	AR_21572438_ChIP-Seq_LNCaP_Human	1.60783452
28	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.58486899
29	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.55412681
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.54962755
31	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.51676477
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.51089063
33	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.49660205
34	RNF2_27304074_Chip-Seq_NSC_Mouse	1.49640875
35	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.48950812
36	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.42433483
37	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.42225628
38	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.41655048
39	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.41655048
40	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.40496470
41	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.39115026
42	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.38733057
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.38237949
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.37723758
45	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.37313280
46	BCAT_22108803_ChIP-Seq_LS180_Human	1.36699752
47	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.36663789
48	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.35369729
49	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.34242859
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.32567093
51	CBP_20019798_ChIP-Seq_JUKART_Human	1.32567093
52	MYC_18940864_ChIP-ChIP_HL60_Human	1.31873380
53	SMAD4_21799915_ChIP-Seq_A2780_Human	1.31223442
54	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.30337947
55	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.28913704
56	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.28593362
57	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.27971700
58	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.27925648
59	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.27009296
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.24020207
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.24020207
62	STAT3_23295773_ChIP-Seq_U87_Human	1.23723000
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23661204
64	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.22198723
65	AR_25329375_ChIP-Seq_VCAP_Human	1.22031722
66	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.20488038
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.18862595
68	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.18801148
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.16855466
70	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.15788237
71	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.15255136
72	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.15111928
73	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.14584219
74	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.13404470
75	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.13347006
76	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.12400093
77	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.12072937
78	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.11280963
79	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.11280963
80	IRF1_19129219_ChIP-ChIP_H3396_Human	1.11138663
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.10405122
82	TCF4_23295773_ChIP-Seq_U87_Human	1.10340830
83	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.08493929
84	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08450194
85	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.08377895
86	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.08377895
87	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07742976
88	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07123509
89	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.06754882
90	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.05160720
91	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.04440204
92	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.03166495
93	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.01763303
94	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.01290347
95	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01164203
96	NCOR_22424771_ChIP-Seq_293T_Human	1.01005686
97	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.00936705
98	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.00834997
99	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.00499576
100	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.00093750

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.32514554
2	MP0009379_abnormal_foot_pigmentation	2.71987768
3	MP0000566_synostosis	2.59293482
4	MP0004133_heterotaxia	2.53844307
5	MP0003880_abnormal_central_pattern	2.25022260
6	MP0001968_abnormal_touch/_nociception	2.23709101
7	MP0002938_white_spotting	2.15154646
8	MP0006292_abnormal_olfactory_placode	2.10039814
9	MP0004742_abnormal_vestibular_system	2.07408892
10	MP0003136_yellow_coat_color	2.05344165
11	MP0003195_calcinosis	2.05158427
12	MP0005551_abnormal_eye_electrophysiolog	2.04473596
13	MP0002102_abnormal_ear_morphology	2.03969258
14	MP0004885_abnormal_endolymph	1.98555093
15	MP0004142_abnormal_muscle_tone	1.96245954
16	MP0001529_abnormal_vocalization	1.94705096
17	MP0001986_abnormal_taste_sensitivity	1.91660857
18	MP0009745_abnormal_behavioral_response	1.90582743
19	MP0001485_abnormal_pinna_reflex	1.86230930
20	MP0002272_abnormal_nervous_system	1.85763647
21	MP0008877_abnormal_DNA_methylation	1.84507996
22	MP0005423_abnormal_somatic_nervous	1.84383622
23	MP0002653_abnormal_ependyma_morphology	1.79531203
24	MP0003283_abnormal_digestive_organ	1.77674486
25	MP0002735_abnormal_chemical_nociception	1.77103088
26	MP0006276_abnormal_autonomic_nervous	1.70877853
27	MP0006072_abnormal_retinal_apoptosis	1.69894667
28	MP0001486_abnormal_startle_reflex	1.69454491
29	MP0009046_muscle_twitch	1.65181826
30	MP0002277_abnormal_respiratory_mucosa	1.64863245
31	MP0000778_abnormal_nervous_system	1.63176646
32	MP0002734_abnormal_mechanical_nocicepti	1.61570637
33	MP0002736_abnormal_nociception_after	1.61264611
34	MP0000631_abnormal_neuroendocrine_gland	1.60628288
35	MP0002557_abnormal_social/conspecific_i	1.57527797
36	MP0003122_maternal_imprinting	1.57387534
37	MP0008872_abnormal_physiological_respon	1.56384263
38	MP0002572_abnormal_emotion/affect_behav	1.52856722
39	MP0001501_abnormal_sleep_pattern	1.51739470
40	MP0002064_seizures	1.46980769
41	MP0002733_abnormal_thermal_nociception	1.46961680
42	MP0003635_abnormal_synaptic_transmissio	1.46338179
43	MP0004924_abnormal_behavior	1.38108592
44	MP0005386_behavior/neurological_phenoty	1.38108592
45	MP0002095_abnormal_skin_pigmentation	1.35773019
46	MP0001970_abnormal_pain_threshold	1.34961023
47	MP0000026_abnormal_inner_ear	1.34754430
48	MP0005084_abnormal_gallbladder_morpholo	1.34479664
49	MP0002067_abnormal_sensory_capabilities	1.31753422
50	MP0001984_abnormal_olfaction	1.31246635
51	MP0008875_abnormal_xenobiotic_pharmacok	1.30293057
52	MP0002063_abnormal_learning/memory/cond	1.30146623
53	MP0003890_abnormal_embryonic-extraembry	1.28856782
54	MP0005377_hearing/vestibular/ear_phenot	1.27518822
55	MP0003878_abnormal_ear_physiology	1.27518822
56	MP0000427_abnormal_hair_cycle	1.23584713
57	MP0003121_genomic_imprinting	1.20865537
58	MP0005253_abnormal_eye_physiology	1.20215668
59	MP0001905_abnormal_dopamine_level	1.18382888
60	MP0005389_reproductive_system_phenotype	1.15712198
61	MP0004145_abnormal_muscle_electrophysio	1.14969049
62	MP0001919_abnormal_reproductive_system	1.13615468
63	MP0001963_abnormal_hearing_physiology	1.10252755
64	MP0000049_abnormal_middle_ear	1.10128168
65	MP0002234_abnormal_pharynx_morphology	1.09993463
66	MP0003937_abnormal_limbs/digits/tail_de	1.08927710
67	MP0005195_abnormal_posterior_eye	1.08920915
68	MP0001293_anophthalmia	1.08820092
69	MP0002928_abnormal_bile_duct	1.08188353
70	MP0003567_abnormal_fetal_cardiomyocyte	1.06298617
71	MP0001440_abnormal_grooming_behavior	1.04657902
72	MP0003646_muscle_fatigue	1.04361876
73	MP0005646_abnormal_pituitary_gland	1.01661690
74	MP0008995_early_reproductive_senescence	1.01502567
75	MP0002751_abnormal_autonomic_nervous	1.00490280
76	MP0002752_abnormal_somatic_nervous	1.00421674
77	MP0003119_abnormal_digestive_system	0.99916120
78	MP0002160_abnormal_reproductive_system	0.99444826
79	MP0004043_abnormal_pH_regulation	0.98488384
80	MP0002876_abnormal_thyroid_physiology	0.97216137
81	MP0000372_irregular_coat_pigmentation	0.96563355
82	MP0005645_abnormal_hypothalamus_physiol	0.96050246
83	MP0005174_abnormal_tail_pigmentation	0.94677994
84	MP0003787_abnormal_imprinting	0.94154329
85	MP0001324_abnormal_eye_pigmentation	0.90819703
86	MP0002184_abnormal_innervation	0.90572216
87	MP0000383_abnormal_hair_follicle	0.89671546
88	MP0008789_abnormal_olfactory_epithelium	0.89397799
89	MP0000955_abnormal_spinal_cord	0.89105575
90	MP0000647_abnormal_sebaceous_gland	0.88683678
91	MP0003718_maternal_effect	0.88467764
92	MP0005187_abnormal_penis_morphology	0.88329043
93	MP0002909_abnormal_adrenal_gland	0.88092035
94	MP0002837_dystrophic_cardiac_calcinosis	0.86536200
95	MP0002882_abnormal_neuron_morphology	0.86061427
96	MP0002822_catalepsy	0.85272261
97	MP0003938_abnormal_ear_development	0.84888486
98	MP0002638_abnormal_pupillary_reflex	0.83848564
99	MP0003698_abnormal_male_reproductive	0.79894747
100	MP0005394_taste/olfaction_phenotype	0.76885557

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of midbrain morphology (HP:0002418)	4.00204565
2	Molar tooth sign on MRI (HP:0002419)	4.00204565
3	Pancreatic fibrosis (HP:0100732)	3.92856243
4	Pancreatic cysts (HP:0001737)	3.79311989
5	Abnormal respiratory motile cilium morphology (HP:0005938)	3.77775677
6	Abnormal respiratory epithelium morphology (HP:0012253)	3.77775677
7	True hermaphroditism (HP:0010459)	3.61100911
8	Concave nail (HP:0001598)	3.52935651
9	Nephronophthisis (HP:0000090)	3.49600693
10	Congenital stationary night blindness (HP:0007642)	3.38302324
11	Abnormal number of erythroid precursors (HP:0012131)	3.34377627
12	Hyperventilation (HP:0002883)	3.30088514
13	Absent/shortened dynein arms (HP:0200106)	3.24888973
14	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.24888973
15	Abnormality of cells of the erythroid lineage (HP:0012130)	3.06335151
16	Abnormal ciliary motility (HP:0012262)	3.02459077
17	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.00877121
18	Abnormal respiratory motile cilium physiology (HP:0012261)	3.00796516
19	Congenital, generalized hypertrichosis (HP:0004540)	2.96533624
20	Acute necrotizing encephalopathy (HP:0006965)	2.92520391
21	Limb dystonia (HP:0002451)	2.88292883
22	Abnormality of the renal medulla (HP:0100957)	2.79501602
23	Medial flaring of the eyebrow (HP:0010747)	2.79466552
24	Birth length less than 3rd percentile (HP:0003561)	2.77854469
25	Abnormality of the renal cortex (HP:0011035)	2.76154813
26	Type II lissencephaly (HP:0007260)	2.58039775
27	Acute encephalopathy (HP:0006846)	2.56440856
28	Mitochondrial inheritance (HP:0001427)	2.56170928
29	Increased hepatocellular lipid droplets (HP:0006565)	2.53474246
30	Rib fusion (HP:0000902)	2.50863261
31	Focal motor seizures (HP:0011153)	2.50367891
32	Broad-based gait (HP:0002136)	2.49511167
33	Protruding tongue (HP:0010808)	2.49268642
34	Progressive macrocephaly (HP:0004481)	2.49092987
35	Pendular nystagmus (HP:0012043)	2.48509530
36	Abnormality of the labia minora (HP:0012880)	2.46515842
37	Sclerocornea (HP:0000647)	2.45547007
38	Renal cortical cysts (HP:0000803)	2.45021421
39	Lipid accumulation in hepatocytes (HP:0006561)	2.41342946
40	Rhinitis (HP:0012384)	2.38602004
41	Abnormal mitochondria in muscle tissue (HP:0008316)	2.37775177
42	Cystic liver disease (HP:0006706)	2.33833641
43	Chronic hepatic failure (HP:0100626)	2.32724837
44	Patellar aplasia (HP:0006443)	2.30535465
45	Gait imbalance (HP:0002141)	2.30321498
46	Inability to walk (HP:0002540)	2.29735230
47	Oligodactyly (hands) (HP:0001180)	2.28702307
48	Furrowed tongue (HP:0000221)	2.27640716
49	Optic disc pallor (HP:0000543)	2.27588539
50	Hypothermia (HP:0002045)	2.27106022
51	Tubular atrophy (HP:0000092)	2.22899166
52	Male pseudohermaphroditism (HP:0000037)	2.22631086
53	Increased CSF lactate (HP:0002490)	2.18283900
54	Large for gestational age (HP:0001520)	2.17062558
55	Anencephaly (HP:0002323)	2.16585819
56	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.15794509
57	Genital tract atresia (HP:0001827)	2.14248604
58	Bilateral microphthalmos (HP:0007633)	2.14020080
59	Aplasia/Hypoplasia of the patella (HP:0006498)	2.12986138
60	Congenital primary aphakia (HP:0007707)	2.10696615
61	Decreased central vision (HP:0007663)	2.10519766
62	Optic nerve hypoplasia (HP:0000609)	2.08883237
63	Septo-optic dysplasia (HP:0100842)	2.07504497
64	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.07340782
65	Abnormality of alanine metabolism (HP:0010916)	2.07225553
66	Hyperalaninemia (HP:0003348)	2.07225553
67	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.07225553
68	Lissencephaly (HP:0001339)	2.06234685
69	Renal Fanconi syndrome (HP:0001994)	2.05778537
70	Progressive cerebellar ataxia (HP:0002073)	2.04092995
71	Vaginal atresia (HP:0000148)	2.02548637
72	Supernumerary spleens (HP:0009799)	2.00629066
73	Nephrogenic diabetes insipidus (HP:0009806)	1.99677259
74	Attenuation of retinal blood vessels (HP:0007843)	1.99569362
75	Abnormal rod and cone electroretinograms (HP:0008323)	1.98523040
76	Chronic sinusitis (HP:0011109)	1.98175702
77	Cerebellar dysplasia (HP:0007033)	1.95884076
78	Confusion (HP:0001289)	1.93055134
79	Polydipsia (HP:0001959)	1.92705620
80	Abnormal drinking behavior (HP:0030082)	1.92705620
81	Keratoconus (HP:0000563)	1.90407646
82	Increased corneal curvature (HP:0100692)	1.90407646
83	Febrile seizures (HP:0002373)	1.88614465
84	Thyroid-stimulating hormone excess (HP:0002925)	1.87915915
85	3-Methylglutaconic aciduria (HP:0003535)	1.86897395
86	Postaxial foot polydactyly (HP:0001830)	1.84616493
87	Abolished electroretinogram (ERG) (HP:0000550)	1.84443789
88	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.84251983
89	Fair hair (HP:0002286)	1.83950772
90	Congenital hepatic fibrosis (HP:0002612)	1.82572079
91	Hemiparesis (HP:0001269)	1.82520537
92	Chronic otitis media (HP:0000389)	1.79933801
93	Hepatocellular necrosis (HP:0001404)	1.78693832
94	Chorioretinal atrophy (HP:0000533)	1.76537758
95	Dialeptic seizures (HP:0011146)	1.76101828
96	Focal seizures (HP:0007359)	1.75310973
97	Macrocytic anemia (HP:0001972)	1.71321657
98	Occipital encephalocele (HP:0002085)	1.71316214
99	Glycosuria (HP:0003076)	1.70724316
100	Abnormality of urine glucose concentration (HP:0011016)	1.70724316

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	INSRR	4.97256817
2	CASK	3.60886815
3	PNCK	3.50456675
4	ADRBK2	2.96279024
5	FRK	2.88129468
6	WNK4	2.86582992
7	WNK3	2.55222825
8	TAOK3	2.38761726
9	TNIK	2.29686670
10	TLK1	2.19637749
11	MARK1	2.17931717
12	BMPR1B	2.15596697
13	GRK1	2.12575329
14	PINK1	2.06292055
15	MAPK13	1.91399438
16	ZAK	1.72693567
17	DYRK2	1.65444132
18	NTRK2	1.61087721
19	MAPK15	1.55826823
20	STK39	1.51333875
21	MAP3K4	1.35690092
22	OXSR1	1.32053138
23	MAP4K2	1.32005156
24	PRKCG	1.29332478
25	STK16	1.23583598
26	ADRBK1	1.18002940
27	NUAK1	1.15467491
28	DAPK2	1.14901312
29	VRK1	1.14649536
30	ACVR1B	1.14454506
31	DYRK3	1.12715138
32	NME1	1.11647239
33	PAK3	1.07091022
34	EPHB2	1.06411731
35	VRK2	0.92419824
36	NTRK3	0.91872749
37	WEE1	0.90670438
38	MKNK2	0.84964624
39	CAMK2A	0.84483972
40	MST4	0.81365514
41	CAMKK2	0.81303445
42	FGFR2	0.80110986
43	MAPKAPK5	0.78734487
44	TGFBR1	0.77715583
45	PLK4	0.75334104
46	PRKCE	0.74031797
47	BRSK2	0.69961178
48	PHKG2	0.66375908
49	PHKG1	0.66375908
50	PASK	0.66137406
51	TIE1	0.65363737
52	CAMK1G	0.64034118
53	NEK2	0.63192559
54	CHUK	0.62926676
55	MUSK	0.62666427
56	PKN1	0.61721072
57	RPS6KA5	0.59971868
58	STK38L	0.59885745
59	PTK2B	0.59677485
60	TYRO3	0.59626687
61	EPHA4	0.59539842
62	TXK	0.58073068
63	PLK2	0.56839114
64	PRKACA	0.56690345
65	MKNK1	0.56521589
66	MAP2K7	0.55487772
67	MATK	0.54992213
68	CSNK1G2	0.54433377
69	PRKCQ	0.54005142
70	PRKCZ	0.52821002
71	CDK3	0.52190521
72	PRKG1	0.50532297
73	NEK9	0.49328658
74	PLK3	0.48693167
75	CAMK2B	0.48606324
76	TEC	0.47390571
77	PIK3CA	0.47370046
78	STK24	0.47181158
79	MINK1	0.46753436
80	UHMK1	0.46102283
81	STK3	0.45391718
82	GRK7	0.44998922
83	SGK2	0.44798244
84	CAMK1	0.44769858
85	RPS6KA6	0.42820835
86	STK11	0.41637270
87	ERBB2	0.41114737
88	ITK	0.40972050
89	SGK223	0.40602352
90	SGK494	0.40602352
91	DYRK1A	0.39856228
92	OBSCN	0.39376674
93	IRAK2	0.38761667
94	BCKDK	0.38374950
95	SIK2	0.37866511
96	CAMK2D	0.37714567
97	WNK1	0.37499756
98	PRKCA	0.35541497
99	CAMKK1	0.35384357
100	IKBKB	0.35288573

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.80209737
2	Parkinsons disease_Homo sapiens_hsa05012	3.38200161
3	Nicotine addiction_Homo sapiens_hsa05033	3.08089096
4	Ribosome_Homo sapiens_hsa03010	3.07246627
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.83454559
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.76166622
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.56379453
8	Huntingtons disease_Homo sapiens_hsa05016	2.38531031
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.35699321
10	Alzheimers disease_Homo sapiens_hsa05010	2.30869702
11	Phototransduction_Homo sapiens_hsa04744	2.06792913
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.00383150
13	RNA polymerase_Homo sapiens_hsa03020	1.98075415
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.97708032
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.86792032
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.78517941
17	Butanoate metabolism_Homo sapiens_hsa00650	1.77851274
18	Protein export_Homo sapiens_hsa03060	1.77366052
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.74580512
20	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.73663022
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.73111887
22	Taste transduction_Homo sapiens_hsa04742	1.69442916
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.68852583
24	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.53596320
25	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.52412639
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.50007953
27	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.48201256
28	Homologous recombination_Homo sapiens_hsa03440	1.45203668
29	Basal transcription factors_Homo sapiens_hsa03022	1.44692233
30	Caffeine metabolism_Homo sapiens_hsa00232	1.40421169
31	Olfactory transduction_Homo sapiens_hsa04740	1.35421270
32	Tryptophan metabolism_Homo sapiens_hsa00380	1.28543125
33	Morphine addiction_Homo sapiens_hsa05032	1.28348893
34	Serotonergic synapse_Homo sapiens_hsa04726	1.22372379
35	GABAergic synapse_Homo sapiens_hsa04727	1.16669326
36	Chemical carcinogenesis_Homo sapiens_hsa05204	1.16386678
37	Glutamatergic synapse_Homo sapiens_hsa04724	1.15480584
38	Fanconi anemia pathway_Homo sapiens_hsa03460	1.14319784
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.11098223
40	Cocaine addiction_Homo sapiens_hsa05030	1.07884057
41	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.05729570
42	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.03776569
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.98688797
44	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.98520099
45	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.97239319
46	Peroxisome_Homo sapiens_hsa04146	0.97198482
47	RNA degradation_Homo sapiens_hsa03018	0.96505248
48	Circadian entrainment_Homo sapiens_hsa04713	0.94576072
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.92131170
50	One carbon pool by folate_Homo sapiens_hsa00670	0.89825056
51	Basal cell carcinoma_Homo sapiens_hsa05217	0.87327569
52	Insulin secretion_Homo sapiens_hsa04911	0.83688456
53	Amphetamine addiction_Homo sapiens_hsa05031	0.80910641
54	Fat digestion and absorption_Homo sapiens_hsa04975	0.80762739
55	Propanoate metabolism_Homo sapiens_hsa00640	0.78734696
56	Dopaminergic synapse_Homo sapiens_hsa04728	0.78732731
57	Retinol metabolism_Homo sapiens_hsa00830	0.73959610
58	Proteasome_Homo sapiens_hsa03050	0.73523140
59	Steroid biosynthesis_Homo sapiens_hsa00100	0.70435772
60	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.69678507
61	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.68805274
62	Calcium signaling pathway_Homo sapiens_hsa04020	0.67336198
63	Sulfur relay system_Homo sapiens_hsa04122	0.64400776
64	Purine metabolism_Homo sapiens_hsa00230	0.63705397
65	Histidine metabolism_Homo sapiens_hsa00340	0.63607452
66	Metabolic pathways_Homo sapiens_hsa01100	0.60769201
67	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.60016900
68	ABC transporters_Homo sapiens_hsa02010	0.58364996
69	Cholinergic synapse_Homo sapiens_hsa04725	0.58039825
70	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.56440814
71	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.53139196
72	Folate biosynthesis_Homo sapiens_hsa00790	0.52817753
73	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.52312691
74	Pyrimidine metabolism_Homo sapiens_hsa00240	0.51123765
75	Mineral absorption_Homo sapiens_hsa04978	0.48370237
76	Collecting duct acid secretion_Homo sapiens_hsa04966	0.45324964
77	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.43525933
78	Long-term depression_Homo sapiens_hsa04730	0.40583324
79	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.39614077
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.39462276
81	Primary immunodeficiency_Homo sapiens_hsa05340	0.39322634
82	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.36152352
83	Axon guidance_Homo sapiens_hsa04360	0.35872042
84	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.35855327
85	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.34968311
86	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.34657391
87	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.34207156
88	Salivary secretion_Homo sapiens_hsa04970	0.33243102
89	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.32931566
90	cAMP signaling pathway_Homo sapiens_hsa04024	0.32436539
91	Tyrosine metabolism_Homo sapiens_hsa00350	0.32235882
92	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.31144219
93	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.30807848
94	beta-Alanine metabolism_Homo sapiens_hsa00410	0.30748730
95	Nucleotide excision repair_Homo sapiens_hsa03420	0.28703303
96	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.26595743
97	Gastric acid secretion_Homo sapiens_hsa04971	0.25071267
98	Hippo signaling pathway_Homo sapiens_hsa04390	0.24442677
99	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.22980322
100	Glutathione metabolism_Homo sapiens_hsa00480	0.22428133

OR4F13P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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