OR4F17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular ketone body metabolic process (GO:0046950)9.91761008
2ketone body metabolic process (GO:1902224)8.77977046
3* detection of chemical stimulus involved in sensory perception of smell (GO:0050911)8.62058595
4regulation of memory T cell differentiation (GO:0043380)7.98073629
5proteasome assembly (GO:0043248)7.44778433
6DNA topological change (GO:0006265)6.93887637
7DNA replication checkpoint (GO:0000076)5.79492918
8sensory perception of chemical stimulus (GO:0007606)5.73492427
9synapsis (GO:0007129)5.49598057
10erythrocyte maturation (GO:0043249)5.47182915
11* detection of chemical stimulus involved in sensory perception (GO:0050907)5.40653527
12peptidyl-histidine modification (GO:0018202)5.33717404
13rRNA methylation (GO:0031167)5.29171743
14positive regulation of interleukin-17 production (GO:0032740)5.18600441
15regulation of activation of Janus kinase activity (GO:0010533)5.07219905
16regulation of translational fidelity (GO:0006450)4.44516392
17rRNA modification (GO:0000154)4.42909558
18positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.32469804
19positive regulation of dendritic spine morphogenesis (GO:0061003)4.31660279
20mannose metabolic process (GO:0006013)4.19140468
21inner mitochondrial membrane organization (GO:0007007)4.17911408
22chromosome organization involved in meiosis (GO:0070192)4.01151766
23centriole replication (GO:0007099)3.96025791
24nuclear pore complex assembly (GO:0051292)3.94560331
25regulation of centriole replication (GO:0046599)3.93630464
26definitive hemopoiesis (GO:0060216)3.90510952
27regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.88299605
28heparin metabolic process (GO:0030202)3.87191819
29heparin biosynthetic process (GO:0030210)3.87191819
30* detection of chemical stimulus (GO:0009593)3.85162337
31histone H2A acetylation (GO:0043968)3.83350790
32protoporphyrinogen IX metabolic process (GO:0046501)3.80720499
33embryonic placenta development (GO:0001892)3.78956701
34mitochondrial RNA metabolic process (GO:0000959)3.76075942
35tRNA aminoacylation for protein translation (GO:0006418)3.76062444
36positive regulation of natural killer cell activation (GO:0032816)3.72692181
37male meiosis I (GO:0007141)3.70344910
38resolution of meiotic recombination intermediates (GO:0000712)3.67439036
39protein localization to kinetochore (GO:0034501)3.65303237
40double-strand break repair via homologous recombination (GO:0000724)3.59274396
41amino acid activation (GO:0043038)3.57407381
42tRNA aminoacylation (GO:0043039)3.57407381
43granulocyte differentiation (GO:0030851)3.57012269
44meiotic chromosome segregation (GO:0045132)3.55061034
45recombinational repair (GO:0000725)3.51667128
46DNA replication initiation (GO:0006270)3.47469149
47erythrocyte development (GO:0048821)3.43330210
48hematopoietic stem cell differentiation (GO:0060218)3.41246932
49mitotic nuclear envelope disassembly (GO:0007077)3.38425750
50mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.33390609
51positive regulation of cell cycle G2/M phase transition (GO:1902751)3.32130014
52positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.32130014
53regulation of double-strand break repair via homologous recombination (GO:0010569)3.32047400
54regulation of histone H3-K4 methylation (GO:0051569)3.28569916
55DNA damage induced protein phosphorylation (GO:0006975)3.28327194
56positive regulation of T-helper 1 type immune response (GO:0002827)3.26949746
57pore complex assembly (GO:0046931)3.21425290
58nuclear pore organization (GO:0006999)3.18477010
59negative regulation of DNA-dependent DNA replication (GO:2000104)3.17209037
60meiosis I (GO:0007127)3.16731397
61membrane disassembly (GO:0030397)3.12234390
62nuclear envelope disassembly (GO:0051081)3.12234390
63negative regulation of histone acetylation (GO:0035067)3.09721815
64cellular response to cholesterol (GO:0071397)3.07868147
65protoporphyrinogen IX biosynthetic process (GO:0006782)3.06850800
66oligosaccharide catabolic process (GO:0009313)3.02451773
67positive regulation of cell fate commitment (GO:0010455)3.00445326
68regulation of nuclear cell cycle DNA replication (GO:0033262)2.98798728
69negative regulation of fatty acid biosynthetic process (GO:0045717)2.98702327
70ADP metabolic process (GO:0046031)2.98284936
71negative regulation of appetite (GO:0032099)2.98038482
72negative regulation of response to food (GO:0032096)2.98038482
73centriole assembly (GO:0098534)2.97238977
74platelet formation (GO:0030220)2.95028206
75positive regulation of T-helper cell differentiation (GO:0045624)2.93450694
76negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.91736467
77telomere maintenance via recombination (GO:0000722)2.91519485
78positive regulation of erythrocyte differentiation (GO:0045648)2.90447594
79misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.89486547
80negative regulation of interleukin-10 production (GO:0032693)2.89299785
81positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.87837661
82ubiquinone biosynthetic process (GO:0006744)2.84669597
83negative regulation of heart rate (GO:0010459)2.84463420
84nucleobase biosynthetic process (GO:0046112)2.83421073
85DNA strand elongation involved in DNA replication (GO:0006271)2.81412652
86cellular response to sterol (GO:0036315)2.80729906
87purine nucleobase biosynthetic process (GO:0009113)2.79857225
88regulation of natural killer cell activation (GO:0032814)2.78359963
89negative regulation of protein acetylation (GO:1901984)2.77987715
90positive regulation of defense response to virus by host (GO:0002230)2.77476696
91telomere maintenance via semi-conservative replication (GO:0032201)2.75927977
92IMP biosynthetic process (GO:0006188)2.75363593
93reciprocal meiotic recombination (GO:0007131)2.75149465
94reciprocal DNA recombination (GO:0035825)2.75149465
95embryonic hemopoiesis (GO:0035162)2.75045971
96mitotic G2/M transition checkpoint (GO:0044818)2.71445822
97DNA strand elongation (GO:0022616)2.70377012
98poly(A)+ mRNA export from nucleus (GO:0016973)2.70215313
99regulation of penile erection (GO:0060405)2.70092818
100sensory perception of smell (GO:0007608)10.6206147

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse9.14919586
2E2F7_22180533_ChIP-Seq_HELA_Human7.56849890
3ESR1_15608294_ChIP-ChIP_MCF-7_Human4.36103035
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.02057794
5VDR_22108803_ChIP-Seq_LS180_Human3.44850001
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.35175075
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.11721935
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.87209777
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.86168685
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.84885511
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.78787356
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.73650601
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.59167304
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.37366786
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.29750890
16NCOR1_26117541_ChIP-Seq_K562_Human2.27527260
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.26137578
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10939750
19GATA1_19941826_ChIP-Seq_K562_Human2.00841135
20DCP1A_22483619_ChIP-Seq_HELA_Human1.97189653
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.95123778
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.89988763
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.88666068
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.84863749
25ZNF274_21170338_ChIP-Seq_K562_Hela1.82295161
26GATA1_22025678_ChIP-Seq_K562_Human1.73219991
27KDM5A_27292631_Chip-Seq_BREAST_Human1.69054533
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68275097
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.63870810
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.57050420
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52029781
32VDR_23849224_ChIP-Seq_CD4+_Human1.48909435
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47922866
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46894320
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.43619716
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.42380809
37FOXP3_21729870_ChIP-Seq_TREG_Human1.39158341
38SPI1_23127762_ChIP-Seq_K562_Human1.35122669
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.34345634
40GATA2_19941826_ChIP-Seq_K562_Human1.33597066
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32939567
42SCL_19346495_ChIP-Seq_HPC-7_Human1.32752890
43CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29452421
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28398786
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28091839
46ER_23166858_ChIP-Seq_MCF-7_Human1.23714565
47XRN2_22483619_ChIP-Seq_HELA_Human1.23197503
48PHF8_20622853_ChIP-Seq_HELA_Human1.21836172
49CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.20313193
50GABP_19822575_ChIP-Seq_HepG2_Human1.19345029
51MYC_18940864_ChIP-ChIP_HL60_Human1.19204086
52GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.18310632
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17869764
54GATA6_21074721_ChIP-Seq_CACO-2_Human1.15057139
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14889171
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13780397
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.13019638
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12746165
59ELK1_19687146_ChIP-ChIP_HELA_Human1.09262322
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06434757
61E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05990764
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.04784699
63E2F1_17053090_ChIP-ChIP_MCF-7_Human1.04351634
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04124800
65ZNF263_19887448_ChIP-Seq_K562_Human1.03093262
66TDRD3_21172665_ChIP-Seq_MCF-7_Human1.01496795
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99874518
68HNFA_21074721_ChIP-Seq_CACO-2_Human0.99757865
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99286806
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99275812
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98970680
72E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98862451
73TFEB_21752829_ChIP-Seq_HELA_Human0.98694600
74TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98394894
75ETV1_20927104_ChIP-Seq_GIST48_Human0.97705111
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96090905
77PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.95698230
78PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94720752
79NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93951823
80RBPJ_21746931_ChIP-Seq_IB4_Human0.92951856
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92410519
82TTF2_22483619_ChIP-Seq_HELA_Human0.91653806
83CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90150072
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90133649
85THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89256276
86YY1_21170310_ChIP-Seq_MESCs_Mouse0.88994003
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.88878486
88CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87929256
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87368467
90FOXA1_25329375_ChIP-Seq_VCAP_Human0.85069597
91FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85069597
92CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83334817
93CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.82494984
94NFYB_21822215_ChIP-Seq_K562_Human0.81409116
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.80045251
96NFYA_21822215_ChIP-Seq_K562_Human0.79445171
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.79363014
98CBX2_22325352_ChIP-Seq_293T-Rex_Human0.78900722
99STAT1_20625510_ChIP-Seq_HELA_Human0.78614163
100P53_21459846_ChIP-Seq_SAOS-2_Human0.78097669

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence6.34824760
2MP0004885_abnormal_endolymph5.49851445
3MP0005083_abnormal_biliary_tract4.84076062
4MP0004147_increased_porphyrin_level4.57176415
5MP0003786_premature_aging4.20669794
6MP0003950_abnormal_plasma_membrane3.58742471
7MP0008057_abnormal_DNA_replication3.56968895
8MP0008058_abnormal_DNA_repair3.14521055
9MP0002132_abnormal_respiratory_system3.03272146
10MP0010094_abnormal_chromosome_stability2.99011741
11MP0001873_stomach_inflammation2.79695749
12MP0003111_abnormal_nucleus_morphology2.49607230
13MP0000015_abnormal_ear_pigmentation2.48571456
14MP0003656_abnormal_erythrocyte_physiolo2.42654298
15MP0003183_abnormal_peptide_metabolism2.34586305
16MP0009840_abnormal_foam_cell2.29428706
17MP0005174_abnormal_tail_pigmentation2.28977391
18MP0005397_hematopoietic_system_phenotyp2.26432008
19MP0001545_abnormal_hematopoietic_system2.26432008
20MP0004957_abnormal_blastocyst_morpholog2.13945620
21MP0005408_hypopigmentation2.04256824
22MP0003646_muscle_fatigue2.04074188
23MP0005075_abnormal_melanosome_morpholog1.98614394
24MP0006036_abnormal_mitochondrial_physio1.97044232
25MP0002095_abnormal_skin_pigmentation1.63733774
26MP0002160_abnormal_reproductive_system1.62425411
27MP0001929_abnormal_gametogenesis1.57668380
28MP0008007_abnormal_cellular_replicative1.56894185
29MP0003172_abnormal_lysosome_physiology1.56790162
30MP0001919_abnormal_reproductive_system1.53372763
31MP0000678_abnormal_parathyroid_gland1.51280350
32MP0008872_abnormal_physiological_respon1.46810540
33MP0005670_abnormal_white_adipose1.41181980
34MP0008875_abnormal_xenobiotic_pharmacok1.40406857
35MP0002210_abnormal_sex_determination1.38968766
36MP0009697_abnormal_copulation1.38003745
37MP0005410_abnormal_fertilization1.33360255
38MP0004019_abnormal_vitamin_homeostasis1.32342633
39MP0001697_abnormal_embryo_size1.23579177
40MP0009278_abnormal_bone_marrow1.22254641
41MP0006035_abnormal_mitochondrial_morpho1.17901890
42MP0003077_abnormal_cell_cycle1.17877579
43MP0003698_abnormal_male_reproductive1.14642119
44MP0003123_paternal_imprinting1.14633326
45MP0005389_reproductive_system_phenotype1.08725094
46MP0000313_abnormal_cell_death1.06149878
47MP0004134_abnormal_chest_morphology1.05672379
48MP0005646_abnormal_pituitary_gland1.03207162
49MP0001145_abnormal_male_reproductive1.00295963
50MP0005636_abnormal_mineral_homeostasis0.97775418
51MP0003984_embryonic_growth_retardation0.95228793
52MP0000371_diluted_coat_color0.92812149
53MP0005464_abnormal_platelet_physiology0.92784677
54MP0005360_urolithiasis0.92324622
55MP0002088_abnormal_embryonic_growth/wei0.91149887
56MP0000653_abnormal_sex_gland0.90245580
57MP0001501_abnormal_sleep_pattern0.89059812
58MP0005380_embryogenesis_phenotype0.88606337
59MP0001672_abnormal_embryogenesis/_devel0.88606337
60MP0009046_muscle_twitch0.85797113
61MP0000613_abnormal_salivary_gland0.85723336
62MP0000569_abnormal_digit_pigmentation0.85364881
63MP0005332_abnormal_amino_acid0.84502721
64MP0003699_abnormal_female_reproductive0.83625544
65MP0010307_abnormal_tumor_latency0.82607933
66MP0001486_abnormal_startle_reflex0.82361363
67MP0006292_abnormal_olfactory_placode0.81830453
68MP0001529_abnormal_vocalization0.78908305
69MP0003806_abnormal_nucleotide_metabolis0.77233753
70MP0004043_abnormal_pH_regulation0.76085337
71MP0001661_extended_life_span0.74995811
72MP0004142_abnormal_muscle_tone0.73583344
73MP0002075_abnormal_coat/hair_pigmentati0.70292667
74MP0001119_abnormal_female_reproductive0.70200228
75MP0005647_abnormal_sex_gland0.70077395
76MP0000358_abnormal_cell_content/0.68996007
77MP0008932_abnormal_embryonic_tissue0.68441712
78MP0003693_abnormal_embryo_hatching0.66331288
79MP0001186_pigmentation_phenotype0.66261784
80MP0008770_decreased_survivor_rate0.65776020
81MP0002161_abnormal_fertility/fecundity0.65652438
82MP0004947_skin_inflammation0.65195627
83MP0003718_maternal_effect0.64652519
84MP0009764_decreased_sensitivity_to0.62853151
85MP0001663_abnormal_digestive_system0.61647055
86MP0002080_prenatal_lethality0.61609585
87MP0008775_abnormal_heart_ventricle0.59903618
88MP0004233_abnormal_muscle_weight0.56993064
89MP0001764_abnormal_homeostasis0.56673433
90MP0002086_abnormal_extraembryonic_tissu0.56356748
91MP0003943_abnormal_hepatobiliary_system0.55966473
92MP0000427_abnormal_hair_cycle0.55920033
93MP0006072_abnormal_retinal_apoptosis0.48982604
94MP0002638_abnormal_pupillary_reflex0.48590825
95MP0005365_abnormal_bile_salt0.47311054
96MP0002722_abnormal_immune_system0.46375744
97MP0000350_abnormal_cell_proliferation0.45844725
98MP0002229_neurodegeneration0.45685607
99MP0001666_abnormal_nutrient_absorption0.45490940
100MP0005266_abnormal_metabolism0.44782460

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.29823935
2Chromsome breakage (HP:0040012)6.04052605
3Aplasia/Hypoplasia of the uvula (HP:0010293)5.17940004
4Abnormality of DNA repair (HP:0003254)4.99003384
5Hyperthyroidism (HP:0000836)4.92853389
6Ragged-red muscle fibers (HP:0003200)4.83933951
7Abnormality of the preputium (HP:0100587)4.65227738
8Meckel diverticulum (HP:0002245)4.61528421
9Truncus arteriosus (HP:0001660)4.58145514
10Duplicated collecting system (HP:0000081)4.48291099
11Severe visual impairment (HP:0001141)4.43274004
12Abnormality of chromosome stability (HP:0003220)4.33849921
13Abnormality of the ileum (HP:0001549)4.33676387
14Acute necrotizing encephalopathy (HP:0006965)4.27700311
15Acute encephalopathy (HP:0006846)4.24422870
16Small intestinal stenosis (HP:0012848)4.22679565
17Duodenal stenosis (HP:0100867)4.22679565
18Abnormal mitochondria in muscle tissue (HP:0008316)4.17082482
19Abnormality of the renal collecting system (HP:0004742)3.96621584
20Acanthocytosis (HP:0001927)3.85347355
21Clubbing of toes (HP:0100760)3.63990055
22Progressive macrocephaly (HP:0004481)3.63111987
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.58386145
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.58386145
25Abnormality of the carotid arteries (HP:0005344)3.56457965
26Absent thumb (HP:0009777)3.55607495
27Reticulocytopenia (HP:0001896)3.54110713
28Abnormality of the heme biosynthetic pathway (HP:0010472)3.41630034
29Hypertensive crisis (HP:0100735)3.27524370
30Abnormality of the duodenum (HP:0002246)3.26526651
31Abnormality of reticulocytes (HP:0004312)3.15150685
32Albinism (HP:0001022)3.06719258
33Seborrheic dermatitis (HP:0001051)3.01907420
34Type II lissencephaly (HP:0007260)3.01846569
35Reticulocytosis (HP:0001923)2.96695934
36Atelectasis (HP:0100750)2.95560004
37Supernumerary spleens (HP:0009799)2.87510987
383-Methylglutaconic aciduria (HP:0003535)2.86203846
39Abnormality of pyrimidine metabolism (HP:0004353)2.85964585
40Abnormal lung lobation (HP:0002101)2.84647207
41Poikilocytosis (HP:0004447)2.80062438
42Complete atrioventricular canal defect (HP:0001674)2.79108730
43Short middle phalanx of the 5th finger (HP:0004220)2.76889498
44Myelodysplasia (HP:0002863)2.76459006
45Abnormality of the tricuspid valve (HP:0001702)2.76303854
46Atrioventricular canal defect (HP:0006695)2.74819208
47Aplasia/Hypoplasia of the earlobes (HP:0009906)2.70992253
48Bowel incontinence (HP:0002607)2.67414340
49Abnormality of cochlea (HP:0000375)2.61049030
50Abnormal large intestine physiology (HP:0012700)2.57337623
51Poikiloderma (HP:0001029)2.57133250
52Increased CSF lactate (HP:0002490)2.50491906
53Spastic tetraparesis (HP:0001285)2.49015669
54Cerebral edema (HP:0002181)2.46547634
55Short thumb (HP:0009778)2.40075894
56Overlapping toe (HP:0001845)2.39737466
57Hypoparathyroidism (HP:0000829)2.38124163
58Short 5th finger (HP:0009237)2.37439857
59Hypergonadotropic hypogonadism (HP:0000815)2.33756106
60Protruding tongue (HP:0010808)2.32130216
61Entropion (HP:0000621)2.31914695
62Abnormality of the phalanges of the hallux (HP:0010057)2.29452913
63Arteriovenous malformation (HP:0100026)2.28562009
64Mitochondrial inheritance (HP:0001427)2.28246537
65Aplasia/Hypoplasia of the thymus (HP:0010515)2.24699535
66Aplasia/Hypoplasia of the tibia (HP:0005772)2.24603277
67Ectopic kidney (HP:0000086)2.20655919
68Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.19826056
69Tracheal stenosis (HP:0002777)2.19786266
70Prolonged bleeding time (HP:0003010)2.14955284
71Triphalangeal thumb (HP:0001199)2.13982210
72Ureteral duplication (HP:0000073)2.13265545
73Short tibia (HP:0005736)2.10483326
74Sloping forehead (HP:0000340)2.09693303
75Ventricular fibrillation (HP:0001663)2.09661955
76Retinal dysplasia (HP:0007973)2.07892584
77Pallor (HP:0000980)2.06252824
78Limb hypertonia (HP:0002509)2.05378467
79Upslanted palpebral fissure (HP:0000582)2.04459758
80Bone marrow hypocellularity (HP:0005528)2.04202571
81Hypoplastic pelvis (HP:0008839)2.03470485
82Hepatocellular necrosis (HP:0001404)2.02492316
83Duplication of thumb phalanx (HP:0009942)2.01555973
84Polycythemia (HP:0001901)2.00715184
85Increased serum lactate (HP:0002151)2.00292766
86Patellar dislocation (HP:0002999)2.00047214
87Acute myeloid leukemia (HP:0004808)1.99269551
88Fatigue (HP:0012378)1.97916024
89Abnormal number of erythroid precursors (HP:0012131)1.93371005
90Hepatic necrosis (HP:0002605)1.92666151
91Progressive muscle weakness (HP:0003323)1.91431750
92Morphological abnormality of the inner ear (HP:0011390)1.89219344
93Oligohydramnios (HP:0001562)1.89008894
94Aganglionic megacolon (HP:0002251)1.87617727
95Type I transferrin isoform profile (HP:0003642)1.85273139
96Cafe-au-lait spot (HP:0000957)1.84056538
97Hypoplasia of the pons (HP:0012110)1.83529730
98Paralysis (HP:0003470)1.80188186
99Ileus (HP:0002595)1.79557687
100Heterotopia (HP:0002282)1.76692546

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK15.39502939
2BRSK24.68745329
3PLK44.49987684
4CDC74.14801623
5NTRK33.26504595
6NUAK13.11186344
7WEE12.98404794
8TTK2.93434723
9KSR22.64204641
10ZAK2.60825403
11RAF12.54287510
12RIPK42.42338244
13NEK12.36712246
14MAPK112.36110149
15BRSK12.04975606
16CCNB11.99194761
17CLK11.96974191
18WNK41.82419726
19MAP4K21.78483557
20FRK1.66109660
21CHEK21.65473769
22TEC1.49955041
23MAP3K21.47105056
24BMPR21.45367219
25KSR11.43027371
26MAP2K11.37912105
27PRKAA11.27009276
28EPHA31.21321801
29MAP3K81.19447684
30ATR1.16780714
31TYK21.14952124
32YES11.14852609
33NEK21.05445258
34PDK21.04311548
35MARK31.01534106
36PLK10.98912329
37SRPK10.94193839
38IRAK30.91809621
39NME10.90435838
40MAP3K90.85299110
41ATM0.78994653
42TNIK0.78635645
43ADRBK20.77936378
44PLK20.75428855
45MAP2K30.63259515
46MAPK120.62887825
47PLK30.62459476
48CHEK10.61022873
49RPS6KA50.60267140
50TAOK30.55201334
51CDK10.54481502
52INSRR0.54280821
53MAP3K130.54090436
54MAPK100.53227135
55JAK10.51905361
56ERBB40.49350074
57SGK10.47057972
58MAP2K60.45378108
59BMPR1B0.45233128
60ERBB30.40864134
61FGFR40.40131458
62CDK40.39824759
63MAP3K40.38234484
64PINK10.37907675
65MAPK140.37003280
66BRD40.35444178
67ALK0.35074568
68CDK20.34793918
69DAPK10.33573048
70JAK20.33563395
71WNK10.33118572
72MST40.33116718
73RPS6KA40.33062245
74GSK3B0.31816783
75CAMK40.30977482
76PIK3CG0.29120518
77ITK0.28553651
78CSNK2A20.28202099
79PKN10.28190751
80MAPK30.28164020
81STK40.27346518
82MAP2K40.26015821
83PRKDC0.25184155
84EPHB10.24338771
85HIPK20.23899620
86BMX0.23319408
87CSNK2A10.22862412
88FGR0.22799074
89IRAK10.22697411
90AURKB0.22599481
91BTK0.22238052
92EIF2AK20.21616167
93MAPK10.21156407
94NEK60.19109238
95PRKCQ0.18585951
96MTOR0.18577886
97MAPKAPK20.18270248
98ERBB20.17244674
99AURKA0.16940938
100VRK10.16683631

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.46431475
2Homologous recombination_Homo sapiens_hsa034405.57477624
3Fanconi anemia pathway_Homo sapiens_hsa034605.03690947
4Butanoate metabolism_Homo sapiens_hsa006504.77369414
5* Olfactory transduction_Homo sapiens_hsa047404.42780595
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.71636710
7Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.72545458
8Steroid biosynthesis_Homo sapiens_hsa001002.56231094
9DNA replication_Homo sapiens_hsa030302.21890875
10One carbon pool by folate_Homo sapiens_hsa006702.14353095
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92193905
12RNA polymerase_Homo sapiens_hsa030201.73369473
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65213325
14Mismatch repair_Homo sapiens_hsa034301.53223818
15RNA transport_Homo sapiens_hsa030131.52889606
16Oxidative phosphorylation_Homo sapiens_hsa001901.32304738
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.28719225
18Cell cycle_Homo sapiens_hsa041101.27287204
19Nucleotide excision repair_Homo sapiens_hsa034201.15916914
20Selenocompound metabolism_Homo sapiens_hsa004501.13882359
21Base excision repair_Homo sapiens_hsa034101.13824495
22Basal transcription factors_Homo sapiens_hsa030221.10392652
23Spliceosome_Homo sapiens_hsa030401.07657975
24Parkinsons disease_Homo sapiens_hsa050121.03386539
25N-Glycan biosynthesis_Homo sapiens_hsa005100.95009974
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92212492
27Huntingtons disease_Homo sapiens_hsa050160.86883668
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83558749
29Fructose and mannose metabolism_Homo sapiens_hsa000510.82353004
30Ribosome_Homo sapiens_hsa030100.78690253
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78554903
32Fatty acid metabolism_Homo sapiens_hsa012120.76833984
33mRNA surveillance pathway_Homo sapiens_hsa030150.70997561
34NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70941482
35Lysine degradation_Homo sapiens_hsa003100.70564522
36Alzheimers disease_Homo sapiens_hsa050100.70424574
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69031188
38Pyrimidine metabolism_Homo sapiens_hsa002400.67604573
39Purine metabolism_Homo sapiens_hsa002300.65042768
40Vitamin B6 metabolism_Homo sapiens_hsa007500.62343882
41Taste transduction_Homo sapiens_hsa047420.61895721
42Nitrogen metabolism_Homo sapiens_hsa009100.60373640
43Oocyte meiosis_Homo sapiens_hsa041140.59341724
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55117656
45Arginine biosynthesis_Homo sapiens_hsa002200.53636331
46Other glycan degradation_Homo sapiens_hsa005110.51412405
47Metabolic pathways_Homo sapiens_hsa011000.50556014
48Retinol metabolism_Homo sapiens_hsa008300.49461369
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48918338
50Non-homologous end-joining_Homo sapiens_hsa034500.48507860
51RNA degradation_Homo sapiens_hsa030180.47037331
52Linoleic acid metabolism_Homo sapiens_hsa005910.44861888
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44802216
54ABC transporters_Homo sapiens_hsa020100.43849971
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.43130850
56Fat digestion and absorption_Homo sapiens_hsa049750.41582355
57Ether lipid metabolism_Homo sapiens_hsa005650.41366788
58Thyroid hormone synthesis_Homo sapiens_hsa049180.39210982
59Sphingolipid metabolism_Homo sapiens_hsa006000.36196341
60Caffeine metabolism_Homo sapiens_hsa002320.33120041
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31538187
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.28675696
63Propanoate metabolism_Homo sapiens_hsa006400.27582835
64Cardiac muscle contraction_Homo sapiens_hsa042600.27248043
65Glycerolipid metabolism_Homo sapiens_hsa005610.27230156
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25766588
67Acute myeloid leukemia_Homo sapiens_hsa052210.23917994
68HIF-1 signaling pathway_Homo sapiens_hsa040660.19927380
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19802145
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18816614
71Apoptosis_Homo sapiens_hsa042100.18626307
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.18256422
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18075013
74Dorso-ventral axis formation_Homo sapiens_hsa043200.16695565
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.16485708
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16089277
77Viral carcinogenesis_Homo sapiens_hsa052030.15568158
78Nicotine addiction_Homo sapiens_hsa050330.15158213
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.14472720
80Chemical carcinogenesis_Homo sapiens_hsa052040.13924240
81Alcoholism_Homo sapiens_hsa050340.11680883
82Prolactin signaling pathway_Homo sapiens_hsa049170.11380522
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.11138945
84Pyruvate metabolism_Homo sapiens_hsa006200.10971508
85Biosynthesis of amino acids_Homo sapiens_hsa012300.10226082
86Fatty acid elongation_Homo sapiens_hsa000620.09795800
87p53 signaling pathway_Homo sapiens_hsa041150.09677741
88TNF signaling pathway_Homo sapiens_hsa046680.09396039
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.07876865
90Tyrosine metabolism_Homo sapiens_hsa003500.07593035
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.07499659
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.06467462
93Tryptophan metabolism_Homo sapiens_hsa003800.05806610
94Insulin secretion_Homo sapiens_hsa049110.05666557
95Dopaminergic synapse_Homo sapiens_hsa047280.04341890
96Cocaine addiction_Homo sapiens_hsa050300.04330897
97Mineral absorption_Homo sapiens_hsa049780.03766955
98Estrogen signaling pathway_Homo sapiens_hsa049150.02874424
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.02182745
100Hepatitis B_Homo sapiens_hsa051610.01066913

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