OR4F3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of uterine smooth muscle contraction (GO:0070474)8.09300570
2acrosome assembly (GO:0001675)7.80766273
3cellular extravasation (GO:0045123)7.80240223
4negative regulation of stress fiber assembly (GO:0051497)6.77023582
5positive regulation of inositol phosphate biosynthetic process (GO:0060732)6.75364778
6regulation of uterine smooth muscle contraction (GO:0070472)6.37565945
7rRNA methylation (GO:0031167)6.30176904
8corticosteroid receptor signaling pathway (GO:0031958)6.19755621
9auditory receptor cell differentiation (GO:0042491)6.07329343
10negative regulation of Rho protein signal transduction (GO:0035024)5.94856437
11positive regulation of mast cell activation involved in immune response (GO:0033008)5.93921191
12positive regulation of mast cell degranulation (GO:0043306)5.93921191
13rRNA modification (GO:0000154)5.71335753
14negative regulation of actin filament bundle assembly (GO:0032232)5.25674553
15regulation of DNA methylation (GO:0044030)5.20057562
16regulation of DNA damage checkpoint (GO:2000001)5.18296085
17regulation of inositol phosphate biosynthetic process (GO:0010919)5.17865804
18positive regulation of phosphoprotein phosphatase activity (GO:0032516)5.06707389
19phagocytosis, recognition (GO:0006910)5.05233782
20regulation of hippo signaling (GO:0035330)4.86512528
21regulation of gene silencing by RNA (GO:0060966)4.86430151
22regulation of posttranscriptional gene silencing (GO:0060147)4.86430151
23regulation of gene silencing by miRNA (GO:0060964)4.86430151
24negative regulation of smooth muscle cell migration (GO:0014912)4.84436843
25positive regulation of mast cell activation (GO:0033005)4.68468825
26positive regulation of endothelial cell apoptotic process (GO:2000353)4.61903349
27phosphorelay signal transduction system (GO:0000160)4.60178976
28positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.59183194
29ventricular system development (GO:0021591)4.54701577
30centriole replication (GO:0007099)4.50361715
31TOR signaling (GO:0031929)4.41661560
32cardiac right ventricle morphogenesis (GO:0003215)4.36190586
33interkinetic nuclear migration (GO:0022027)4.29258055
34nuclear pore complex assembly (GO:0051292)4.26652244
35positive regulation of neurotransmitter secretion (GO:0001956)4.22029194
36phosphatidylinositol dephosphorylation (GO:0046856)4.19185362
37cell-substrate adherens junction assembly (GO:0007045)4.11851343
38focal adhesion assembly (GO:0048041)4.11851343
39regulation of female gonad development (GO:2000194)4.05975320
40negative regulation of cell cycle arrest (GO:0071157)4.04425153
41Notch signaling involved in heart development (GO:0061314)4.02878307
42DNA methylation involved in gamete generation (GO:0043046)3.99410668
43positive regulation of smooth muscle cell migration (GO:0014911)3.97431221
44nuclear pore organization (GO:0006999)3.96914465
45positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.93592673
46phospholipid dephosphorylation (GO:0046839)3.93312615
47cAMP catabolic process (GO:0006198)3.92041542
48nodal signaling pathway (GO:0038092)3.89357223
49retinal cone cell development (GO:0046549)3.89034344
50relaxation of smooth muscle (GO:0044557)3.88389062
51piRNA metabolic process (GO:0034587)3.82659820
52replicative senescence (GO:0090399)3.80527726
53regulation of meiosis I (GO:0060631)3.76759909
54positive regulation of leukocyte degranulation (GO:0043302)3.75954363
55gene silencing by RNA (GO:0031047)3.74732487
56positive regulation of ERBB signaling pathway (GO:1901186)3.72280388
57positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.71511459
58mitochondrial RNA metabolic process (GO:0000959)3.69613939
59positive regulation of histone H3-K4 methylation (GO:0051571)3.66899473
60hair cell differentiation (GO:0035315)3.62892352
61inner ear receptor cell differentiation (GO:0060113)3.62776035
62pore complex assembly (GO:0046931)3.61799186
63cyclic nucleotide catabolic process (GO:0009214)3.59054268
64regulation of execution phase of apoptosis (GO:1900117)3.57620778
65DNA damage response, detection of DNA damage (GO:0042769)3.54004973
66positive regulation of protein dephosphorylation (GO:0035307)3.52218860
67positive regulation of icosanoid secretion (GO:0032305)3.51656737
68positive regulation of fatty acid transport (GO:2000193)3.38124036
69centriole assembly (GO:0098534)3.37812866
70negative regulation of macroautophagy (GO:0016242)3.33558957
71meiotic cell cycle (GO:0051321)3.32392591
72chromosome condensation (GO:0030261)3.29283698
73negative regulation of epidermal cell differentiation (GO:0045605)3.26736719
74viral mRNA export from host cell nucleus (GO:0046784)3.23231268
75regulation of acrosome reaction (GO:0060046)3.13619347
76regulation of NFAT protein import into nucleus (GO:0051532)3.13095074
77regulation of histone H3-K4 methylation (GO:0051569)3.10036429
78male meiosis (GO:0007140)3.09924555
79regulation of G0 to G1 transition (GO:0070316)3.08073687
80synapsis (GO:0007129)3.07273465
81binding of sperm to zona pellucida (GO:0007339)3.04729762
82antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.03980457
83regulation of timing of cell differentiation (GO:0048505)3.02695315
84positive regulation of dephosphorylation (GO:0035306)2.89629769
85positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.89138247
86embryonic process involved in female pregnancy (GO:0060136)2.88171692
87mismatch repair (GO:0006298)2.86418107
88regulation of cell cycle checkpoint (GO:1901976)2.86192021
89DNA damage induced protein phosphorylation (GO:0006975)2.85999793
90regulation of histone H3-K9 methylation (GO:0051570)2.85571649
91regulation of development, heterochronic (GO:0040034)2.84862065
92female gamete generation (GO:0007292)2.84623354
93positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.83945446
94branching involved in prostate gland morphogenesis (GO:0060442)2.83876250
95regulation of RNA export from nucleus (GO:0046831)2.83578920
96regulation of cell maturation (GO:1903429)2.80635369
97neuronal stem cell maintenance (GO:0097150)2.79076152
98multicellular organism reproduction (GO:0032504)2.77847523
99cellular response to estradiol stimulus (GO:0071392)2.77656077
100cellular response to corticosteroid stimulus (GO:0071384)2.76476196

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse8.15892203
2EZH2_22144423_ChIP-Seq_EOC_Human6.24252411
3E2F7_22180533_ChIP-Seq_HELA_Human4.25187314
4GBX2_23144817_ChIP-Seq_PC3_Human3.77596077
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.66931356
6HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse3.43782069
7VDR_22108803_ChIP-Seq_LS180_Human3.24602914
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.21779511
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.60930897
10EWS_26573619_Chip-Seq_HEK293_Human2.48178318
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.45331066
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26322901
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24251259
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.23296372
15FUS_26573619_Chip-Seq_HEK293_Human2.17289901
16GATA1_22025678_ChIP-Seq_K562_Human2.11017764
17TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.96139821
18ZNF274_21170338_ChIP-Seq_K562_Hela1.87698153
19ER_23166858_ChIP-Seq_MCF-7_Human1.86918542
20IRF1_19129219_ChIP-ChIP_H3396_Human1.82620372
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70215577
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63577591
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61992122
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55479875
25VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.53667205
26GATA1_26923725_Chip-Seq_HPCs_Mouse1.50802637
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50802395
28LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50265760
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49560637
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49490213
31TCF4_23295773_ChIP-Seq_U87_Human1.44675288
32RNF2_27304074_Chip-Seq_NSC_Mouse1.42990857
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42076259
34STAT3_23295773_ChIP-Seq_U87_Human1.40335078
35TP53_16413492_ChIP-PET_HCT116_Human1.39103449
36BCAT_22108803_ChIP-Seq_LS180_Human1.38869294
37AR_20517297_ChIP-Seq_VCAP_Human1.34941926
38PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.34437116
39CBP_20019798_ChIP-Seq_JUKART_Human1.33299850
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33299850
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31519063
42FOXP3_21729870_ChIP-Seq_TREG_Human1.31123695
43CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30728862
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.30699813
45KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.30699813
46KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.30699813
47AR_21909140_ChIP-Seq_LNCAP_Human1.30273856
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25270575
49SMAD4_21799915_ChIP-Seq_A2780_Human1.24922492
50RUNX2_22187159_ChIP-Seq_PCA_Human1.20520344
51TAF15_26573619_Chip-Seq_HEK293_Human1.20004458
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16657278
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11774837
54P300_19829295_ChIP-Seq_ESCs_Human1.09908730
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09817741
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09641830
57ETS1_20019798_ChIP-Seq_JURKAT_Human1.05457287
58DROSHA_22980978_ChIP-Seq_HELA_Human1.04281765
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03373423
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.03138400
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02823206
62E2F1_18555785_Chip-Seq_ESCs_Mouse1.01483880
63CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98888417
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98484427
65* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97795211
66SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97625845
67EST1_17652178_ChIP-ChIP_JURKAT_Human0.94409011
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94301712
69PRDM14_20953172_ChIP-Seq_ESCs_Human0.94279574
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94149677
71FLI1_27457419_Chip-Seq_LIVER_Mouse0.93808900
72FLI1_21867929_ChIP-Seq_TH2_Mouse0.93044316
73MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92906542
74TBX3_20139965_ChIP-Seq_ESCs_Mouse0.91619686
75FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91576287
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91543245
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91543245
78CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.90640176
79PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90628053
80PIAS1_25552417_ChIP-Seq_VCAP_Human0.89975917
81TBX3_20139965_ChIP-Seq_MESCs_Mouse0.89147747
82NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88496611
83CBP_21632823_ChIP-Seq_H3396_Human0.88467887
84VDR_23849224_ChIP-Seq_CD4+_Human0.88036395
85NANOG_18555785_Chip-Seq_ESCs_Mouse0.87174165
86P53_22387025_ChIP-Seq_ESCs_Mouse0.86064349
87WDR5_24793694_ChIP-Seq_LNCAP_Human0.85485458
88HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.84917289
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.84108358
90FOXH1_21741376_ChIP-Seq_EPCs_Human0.82341311
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.82114282
92AR_25329375_ChIP-Seq_VCAP_Human0.81413780
93SMAD4_21741376_ChIP-Seq_EPCs_Human0.81096840
94NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.80786433
95TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.80759718
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.80318463
97GATA3_21878914_ChIP-Seq_MCF-7_Human0.79868210
98RXR_22108803_ChIP-Seq_LS180_Human0.79386425
99TAL1_26923725_Chip-Seq_HPCs_Mouse0.78728917
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78190355

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.01915815
2MP0003718_maternal_effect4.76292363
3MP0000569_abnormal_digit_pigmentation4.14453878
4MP0001661_extended_life_span4.06397698
5MP0004233_abnormal_muscle_weight3.33948155
6MP0008789_abnormal_olfactory_epithelium3.32220990
7MP0003252_abnormal_bile_duct3.12026062
8MP0008057_abnormal_DNA_replication2.93392243
9MP0005394_taste/olfaction_phenotype2.73840479
10MP0005499_abnormal_olfactory_system2.73840479
11MP0004147_increased_porphyrin_level2.73624788
12MP0004133_heterotaxia2.72377030
13MP0003121_genomic_imprinting2.70422104
14MP0006292_abnormal_olfactory_placode2.56175562
15MP0003122_maternal_imprinting2.53637052
16MP0008877_abnormal_DNA_methylation2.46642826
17MP0005085_abnormal_gallbladder_physiolo2.32824798
18MP0002928_abnormal_bile_duct1.98293931
19MP0010094_abnormal_chromosome_stability1.84868683
20MP0009046_muscle_twitch1.84211871
21MP0004957_abnormal_blastocyst_morpholog1.81503903
22MP0005408_hypopigmentation1.79387164
23MP0000749_muscle_degeneration1.78937647
24MP0005395_other_phenotype1.73027329
25MP0008058_abnormal_DNA_repair1.68880990
26MP0003566_abnormal_cell_adhesion1.67139950
27MP0001929_abnormal_gametogenesis1.66320834
28MP0003693_abnormal_embryo_hatching1.54124557
29MP0005360_urolithiasis1.53261875
30MP0005075_abnormal_melanosome_morpholog1.53081153
31MP0003656_abnormal_erythrocyte_physiolo1.51248421
32MP0002210_abnormal_sex_determination1.49687665
33MP0003699_abnormal_female_reproductive1.44541069
34MP0010234_abnormal_vibrissa_follicle1.43347368
35MP0006035_abnormal_mitochondrial_morpho1.41374340
36MP0003890_abnormal_embryonic-extraembry1.38899300
37MP0000653_abnormal_sex_gland1.38508194
38MP0001666_abnormal_nutrient_absorption1.38349214
39MP0008932_abnormal_embryonic_tissue1.36531117
40MP0003111_abnormal_nucleus_morphology1.36038626
41MP0008875_abnormal_xenobiotic_pharmacok1.34419134
42MP0002938_white_spotting1.32881348
43MP0000566_synostosis1.31773602
44MP0005174_abnormal_tail_pigmentation1.28853243
45MP0005410_abnormal_fertilization1.26554448
46MP0004036_abnormal_muscle_relaxation1.24921307
47MP0005332_abnormal_amino_acid1.23773237
48MP0001145_abnormal_male_reproductive1.23507582
49MP0009384_cardiac_valve_regurgitation1.23049591
50MP0002234_abnormal_pharynx_morphology1.22700865
51MP0002269_muscular_atrophy1.21747544
52MP0000015_abnormal_ear_pigmentation1.17884959
53MP0003698_abnormal_male_reproductive1.17218538
54MP0002160_abnormal_reproductive_system1.10546526
55MP0002139_abnormal_hepatobiliary_system1.08454479
56MP0000428_abnormal_craniofacial_morphol1.05551806
57MP0003950_abnormal_plasma_membrane1.04678828
58MP0010030_abnormal_orbit_morphology0.99150672
59MP0000465_gastrointestinal_hemorrhage0.95946110
60MP0002233_abnormal_nose_morphology0.95742351
61MP0002272_abnormal_nervous_system0.95483235
62MP0002161_abnormal_fertility/fecundity0.94400016
63MP0008995_early_reproductive_senescence0.92818962
64MP0003868_abnormal_feces_composition0.91012684
65MP0000427_abnormal_hair_cycle0.90733530
66MP0001730_embryonic_growth_arrest0.90656730
67MP0005551_abnormal_eye_electrophysiolog0.89915836
68MP0002108_abnormal_muscle_morphology0.89502618
69MP0004142_abnormal_muscle_tone0.85825581
70MP0002084_abnormal_developmental_patter0.84895672
71MP0005197_abnormal_uvea_morphology0.84055851
72MP0005670_abnormal_white_adipose0.83336761
73MP0002102_abnormal_ear_morphology0.82012532
74MP0000762_abnormal_tongue_morphology0.81515498
75MP0001915_intracranial_hemorrhage0.81379229
76MP0003195_calcinosis0.80753608
77MP0004742_abnormal_vestibular_system0.80187244
78MP0005319_abnormal_enzyme/_coenzyme0.79034864
79MP0003077_abnormal_cell_cycle0.78024805
80MP0003879_abnormal_hair_cell0.77868840
81MP0010307_abnormal_tumor_latency0.75528997
82MP0004043_abnormal_pH_regulation0.72892658
83MP0005380_embryogenesis_phenotype0.71335782
84MP0001672_abnormal_embryogenesis/_devel0.71335782
85MP0004272_abnormal_basement_membrane0.70952606
86MP0000631_abnormal_neuroendocrine_gland0.69533583
87MP0002086_abnormal_extraembryonic_tissu0.64739185
88MP0002085_abnormal_embryonic_tissue0.63639672
89MP0003935_abnormal_craniofacial_develop0.62673648
90MP0005389_reproductive_system_phenotype0.61342689
91MP0008007_abnormal_cellular_replicative0.59364247
92MP0005645_abnormal_hypothalamus_physiol0.59172610
93MP0010678_abnormal_skin_adnexa0.58790092
94MP0002127_abnormal_cardiovascular_syste0.58785582
95MP0003119_abnormal_digestive_system0.56979551
96MP0005220_abnormal_exocrine_pancreas0.55483630
97MP0002095_abnormal_skin_pigmentation0.55364903
98MP0000751_myopathy0.54939877
99MP0001664_abnormal_digestion0.54664161
100MP0001324_abnormal_eye_pigmentation0.54002122

Predicted human phenotypes

RankGene SetZ-score
1Short tibia (HP:0005736)4.97068026
2Aplasia/Hypoplasia of the tibia (HP:0005772)4.69343749
3Metaphyseal dysplasia (HP:0100255)4.64415471
4Anterior segment dysgenesis (HP:0007700)4.55203240
5Papillary thyroid carcinoma (HP:0002895)4.19433465
6Chorioretinal atrophy (HP:0000533)4.10968495
7Abdominal situs inversus (HP:0003363)4.10800451
8Abnormality of abdominal situs (HP:0011620)4.10800451
9Microglossia (HP:0000171)4.05359590
10Median cleft lip (HP:0000161)4.03834606
11Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.75952675
12Pulmonary artery stenosis (HP:0004415)3.68852453
13Abnormality of lateral ventricle (HP:0030047)3.68678596
14Subcapsular cataract (HP:0000523)3.64731769
15Vertebral arch anomaly (HP:0008438)3.59726535
16Fair hair (HP:0002286)3.57863485
17Prolonged neonatal jaundice (HP:0006579)3.51976033
18Facial hemangioma (HP:0000329)3.48041040
19Lip pit (HP:0100267)3.45859190
20Gaze-evoked nystagmus (HP:0000640)3.45589154
21Hypophosphatemic rickets (HP:0004912)3.44239860
22Chromosomal breakage induced by crosslinking agents (HP:0003221)3.40450962
23Supernumerary spleens (HP:0009799)3.24139600
24Chromsome breakage (HP:0040012)3.20419795
25Abnormality of the anterior horn cell (HP:0006802)3.18001261
26Degeneration of anterior horn cells (HP:0002398)3.18001261
27Type I transferrin isoform profile (HP:0003642)3.09223820
28Periodontitis (HP:0000704)3.06181872
29Long nose (HP:0003189)3.05331486
30Thyroid carcinoma (HP:0002890)3.03220855
31Retinal dysplasia (HP:0007973)3.02479899
32Impaired proprioception (HP:0010831)3.01752730
33Conjunctival telangiectasia (HP:0000524)3.00716973
34Abnormal biliary tract morphology (HP:0012440)2.97399231
35Biliary tract neoplasm (HP:0100574)2.97052446
36Skin pits (HP:0100276)2.95314372
37Type II lissencephaly (HP:0007260)2.89709447
38Ankyloglossia (HP:0010296)2.89632438
39Capillary hemangiomas (HP:0005306)2.88878576
40Hypoplasia of the pons (HP:0012110)2.82986177
41Impulsivity (HP:0100710)2.80276252
42Duplicated collecting system (HP:0000081)2.66350902
43Abnormality of the pons (HP:0007361)2.65046817
44Abnormal glycosylation (HP:0012345)2.63601264
45Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.63601264
46Abnormal protein N-linked glycosylation (HP:0012347)2.63601264
47Abnormal protein glycosylation (HP:0012346)2.63601264
48Bifid tongue (HP:0010297)2.60391144
49Focal segmental glomerulosclerosis (HP:0000097)2.58462912
50Reduced antithrombin III activity (HP:0001976)2.54912467
51Glomerulosclerosis (HP:0000096)2.54164928
52Pancreatic fibrosis (HP:0100732)2.49410035
53Generalized aminoaciduria (HP:0002909)2.44524197
54Generalized hypopigmentation of hair (HP:0011358)2.42114083
55Medulloblastoma (HP:0002885)2.39939337
56Abnormality of the renal collecting system (HP:0004742)2.36634376
57Aplasia/Hypoplasia of the tongue (HP:0010295)2.32435494
58Abnormality of the vasculature of the conjunctiva (HP:0008054)2.29425965
59Diminished movement (HP:0002374)2.26992576
60Hypercholesterolemia (HP:0003124)2.26159361
61Gonadotropin excess (HP:0000837)2.26018221
62Male infertility (HP:0003251)2.21490536
63Hepatocellular carcinoma (HP:0001402)2.20212852
64Exocrine pancreatic insufficiency (HP:0001738)2.16758131
65Neoplasm of the rectum (HP:0100743)2.15412262
66Genital tract atresia (HP:0001827)2.14645401
67Abnormality of the lower motor neuron (HP:0002366)2.14184189
68Abnormal gallbladder physiology (HP:0012438)2.13083978
69Cholecystitis (HP:0001082)2.13083978
70Abnormality of the labia minora (HP:0012880)2.09596334
71Mutism (HP:0002300)2.09213581
72Congenital sensorineural hearing impairment (HP:0008527)2.08122228
73Abnormal ventriculo-arterial connection (HP:0011563)2.03833658
74Transposition of the great arteries (HP:0001669)2.03833658
75Abnormal connection of the cardiac segments (HP:0011545)2.03833658
76Preauricular pit (HP:0004467)2.03530235
77Periauricular skin pits (HP:0100277)2.03530235
78Oculomotor apraxia (HP:0000657)2.02291924
79Premature ovarian failure (HP:0008209)1.99173799
80Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.98682552
81Bradykinesia (HP:0002067)1.97862843
82Broad-based gait (HP:0002136)1.97346490
83Posterior subcapsular cataract (HP:0007787)1.96085799
84Prolonged partial thromboplastin time (HP:0003645)1.95799045
85Cone-rod dystrophy (HP:0000548)1.94978697
86Cortical visual impairment (HP:0100704)1.89799804
87Abnormality of chromosome stability (HP:0003220)1.89567464
88Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.89485942
89Akinesia (HP:0002304)1.88785827
90Non-midline cleft lip (HP:0100335)1.88325277
91Scotoma (HP:0000575)1.88055482
92Neoplasm of the small intestine (HP:0100833)1.87380814
93Neoplasm of the oral cavity (HP:0100649)1.84821113
94Aplasia/Hypoplasia of the fovea (HP:0008060)1.84015744
95Hypoplasia of the fovea (HP:0007750)1.84015744
96Abnormality of the anterior chamber (HP:0000593)1.81667441
97Lower limb hyperreflexia (HP:0002395)1.81620815
98Mask-like facies (HP:0000298)1.81338975
99Flat occiput (HP:0005469)1.78702109
100CNS hypomyelination (HP:0003429)1.73821382

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAF18.78133654
2NTRK16.13002867
3NTRK24.70115180
4NTRK32.84511368
5KSR22.76105207
6ZAP702.42458605
7NME12.39048525
8RAF12.16852231
9FRK2.15998027
10MAP3K22.14012301
11ARAF2.10988778
12MAP4K22.03538451
13STK391.69449493
14CCNB11.60702778
15CDK91.50343698
16TTK1.47438111
17PLK41.45919432
18MAP3K91.45751155
19KSR11.37445104
20EPHA41.35344352
21WNK41.32634610
22MAP3K131.32330040
23MET1.29242999
24STK241.26410917
25TAOK31.24952475
26SRPK11.23468983
27ZAK1.23139280
28LMTK21.14379648
29OXSR11.09312507
30MAPK121.06185052
31MST1R1.05093093
32NUAK11.04667448
33BCKDK0.97938634
34NEK60.88070547
35ERN10.84955123
36AURKA0.83095238
37BRAF0.82140237
38PLK10.81665951
39TIE10.81009561
40STK110.80971536
41EIF2AK30.75714438
42PRKCI0.71926974
43CDK120.66870520
44PRKD10.65169415
45WNK10.63901243
46MAPKAPK30.61698081
47KIT0.60227224
48AURKB0.58172714
49MAP3K40.58082025
50MAPK130.56123630
51CDK80.55338995
52MAP2K10.54558892
53JAK20.54186352
54RPS6KB10.51948883
55TRPM70.51642925
56MAP3K80.51608719
57AKT10.51258660
58ATR0.50338222
59MAP3K70.49336675
60PLK30.48738757
61STK30.48529365
62FGFR20.47591646
63PRKG10.47334061
64AKT20.45179942
65ACVR1B0.44092671
66PRKAA10.43592228
67PLK20.41968952
68VRK10.41337254
69BMPR1B0.40815368
70TNIK0.40368637
71CDC70.39458733
72CDK10.39438938
73EEF2K0.37596230
74NEK90.36768914
75PHKG20.36477393
76PHKG10.36477393
77CSNK1E0.35554390
78CDK70.35179030
79PIK3CG0.35138903
80MTOR0.34652575
81EGFR0.33933269
82CHEK10.33486998
83CDK20.32914759
84RET0.30421242
85NEK20.29312916
86MAP2K70.27964672
87MOS0.27571445
88ATM0.25688723
89MAPK10.25385228
90MAP3K10.24842024
91LATS10.24450016
92PINK10.24058730
93EIF2AK10.23238680
94CAMK1D0.21834202
95MST40.21647671
96MARK30.20680773
97MAPK30.19322510
98BMX0.19289842
99CDC42BPA0.16278802
100ERBB40.16016986

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030225.32355938
2ABC transporters_Homo sapiens_hsa020103.59011350
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.27701836
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.99394928
5Homologous recombination_Homo sapiens_hsa034402.91162153
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.80882126
7Mismatch repair_Homo sapiens_hsa034302.74461450
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.52153614
9Fanconi anemia pathway_Homo sapiens_hsa034602.51432168
10Oocyte meiosis_Homo sapiens_hsa041142.25990161
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.95537518
12Inositol phosphate metabolism_Homo sapiens_hsa005621.89706428
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.78115419
14Phosphatidylinositol signaling system_Homo sapiens_hsa040701.75825655
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.70442349
16RNA transport_Homo sapiens_hsa030131.69809207
17DNA replication_Homo sapiens_hsa030301.68548209
18Cell cycle_Homo sapiens_hsa041101.67044947
19Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.64551891
20Caffeine metabolism_Homo sapiens_hsa002321.56786945
21Nucleotide excision repair_Homo sapiens_hsa034201.53403457
22Dorso-ventral axis formation_Homo sapiens_hsa043201.49551678
23ECM-receptor interaction_Homo sapiens_hsa045121.46252804
24Histidine metabolism_Homo sapiens_hsa003401.45205533
25RNA degradation_Homo sapiens_hsa030181.43889021
26Linoleic acid metabolism_Homo sapiens_hsa005911.42603939
27Base excision repair_Homo sapiens_hsa034101.38897053
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.38735165
29Estrogen signaling pathway_Homo sapiens_hsa049151.36903910
30Glioma_Homo sapiens_hsa052141.34172475
31* Olfactory transduction_Homo sapiens_hsa047401.32416488
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.23124231
33Non-homologous end-joining_Homo sapiens_hsa034501.17087498
34Ovarian steroidogenesis_Homo sapiens_hsa049131.10377945
35TGF-beta signaling pathway_Homo sapiens_hsa043501.10295654
36mTOR signaling pathway_Homo sapiens_hsa041501.06448951
37Purine metabolism_Homo sapiens_hsa002301.05918253
38Chronic myeloid leukemia_Homo sapiens_hsa052201.05426226
39ErbB signaling pathway_Homo sapiens_hsa040120.98727221
40Long-term depression_Homo sapiens_hsa047300.96606984
41Lysine degradation_Homo sapiens_hsa003100.95960219
42Phospholipase D signaling pathway_Homo sapiens_hsa040720.94035607
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92761830
44Pyruvate metabolism_Homo sapiens_hsa006200.91969026
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91955394
46Spliceosome_Homo sapiens_hsa030400.88157750
47Taste transduction_Homo sapiens_hsa047420.85161002
48N-Glycan biosynthesis_Homo sapiens_hsa005100.85082018
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.83709456
50RNA polymerase_Homo sapiens_hsa030200.78981932
51Phototransduction_Homo sapiens_hsa047440.78569067
52Ether lipid metabolism_Homo sapiens_hsa005650.76594063
53Fat digestion and absorption_Homo sapiens_hsa049750.76487943
54Thyroid hormone synthesis_Homo sapiens_hsa049180.70169676
55Salivary secretion_Homo sapiens_hsa049700.69565402
56Morphine addiction_Homo sapiens_hsa050320.69273588
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.68624544
58Gap junction_Homo sapiens_hsa045400.67254286
59Selenocompound metabolism_Homo sapiens_hsa004500.66647850
60mRNA surveillance pathway_Homo sapiens_hsa030150.60205477
61Type II diabetes mellitus_Homo sapiens_hsa049300.59544125
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59257820
63Retinol metabolism_Homo sapiens_hsa008300.57468436
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.56908693
65Arginine and proline metabolism_Homo sapiens_hsa003300.53442070
66Vitamin digestion and absorption_Homo sapiens_hsa049770.52660797
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48751034
68Sulfur relay system_Homo sapiens_hsa041220.45946247
69Folate biosynthesis_Homo sapiens_hsa007900.43977397
70Glycerolipid metabolism_Homo sapiens_hsa005610.43180163
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40699791
72Glucagon signaling pathway_Homo sapiens_hsa049220.40096914
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39819222
74Viral carcinogenesis_Homo sapiens_hsa052030.39640637
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.39378320
76Insulin signaling pathway_Homo sapiens_hsa049100.38477580
77p53 signaling pathway_Homo sapiens_hsa041150.38213986
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38140570
79Huntingtons disease_Homo sapiens_hsa050160.36238259
80Chemical carcinogenesis_Homo sapiens_hsa052040.35811598
81Mineral absorption_Homo sapiens_hsa049780.34046558
82Propanoate metabolism_Homo sapiens_hsa006400.33764582
83One carbon pool by folate_Homo sapiens_hsa006700.32376482
84Serotonergic synapse_Homo sapiens_hsa047260.32260591
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31982716
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31316958
87Prostate cancer_Homo sapiens_hsa052150.28972006
88Nicotine addiction_Homo sapiens_hsa050330.28610395
89Choline metabolism in cancer_Homo sapiens_hsa052310.28068139
90Long-term potentiation_Homo sapiens_hsa047200.27397978
91Metabolic pathways_Homo sapiens_hsa011000.26510663
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.25272443
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.24559265
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24539014
95Pyrimidine metabolism_Homo sapiens_hsa002400.24104282
96Dilated cardiomyopathy_Homo sapiens_hsa054140.23590984
97Prolactin signaling pathway_Homo sapiens_hsa049170.22865397
98Insulin resistance_Homo sapiens_hsa049310.22176242
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21602108
100Acute myeloid leukemia_Homo sapiens_hsa052210.21560250

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