ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	outflow tract septum morphogenesis (GO:0003148)	8.17936837
2	striatum development (GO:0021756)	8.05534053
3	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	7.88527310
4	nucleoside transport (GO:0015858)	6.94036390
5	embryonic digestive tract development (GO:0048566)	6.80480193
6	negative regulation of execution phase of apoptosis (GO:1900118)	6.77099856
7	platelet dense granule organization (GO:0060155)	6.69208902
8	glandular epithelial cell development (GO:0002068)	6.35975611
9	glucosamine-containing compound catabolic process (GO:1901072)	5.96324825
10	glycine transport (GO:0015816)	5.88926559
11	cell wall macromolecule metabolic process (GO:0044036)	5.88908984
12	phospholipid scrambling (GO:0017121)	5.69555660
13	positive regulation of chemokine secretion (GO:0090197)	5.37793132
14	retinoic acid receptor signaling pathway (GO:0048384)	5.37296905
15	negative regulation of chondrocyte differentiation (GO:0032331)	5.33346435
16	thrombin receptor signaling pathway (GO:0070493)	5.23104453
17	T cell migration (GO:0072678)	4.79839737
18	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	4.75057782
19	regulation of female gonad development (GO:2000194)	4.65602149
20	regulation of chemokine secretion (GO:0090196)	4.53309956
21	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.49210855
22	neuronal action potential (GO:0019228)	4.31563423
23	positive regulation of action potential (GO:0045760)	4.24431311
24	positive regulation of interleukin-4 production (GO:0032753)	4.23953445
25	positive regulation of prostaglandin secretion (GO:0032308)	4.20372103
26	negative regulation of stress fiber assembly (GO:0051497)	4.19360495
27	regulation of DNA methylation (GO:0044030)	4.11424119
28	cardiac muscle cell differentiation (GO:0055007)	4.10815358
29	proteasome assembly (GO:0043248)	4.10458311
30	negative regulation of actin filament bundle assembly (GO:0032232)	4.01337451
31	regulation of meiosis I (GO:0060631)	4.01114504
32	negative T cell selection (GO:0043383)	3.96353445
33	male meiosis I (GO:0007141)	3.91307172
34	positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)	3.89602037
35	negative regulation of cartilage development (GO:0061037)	3.88347567
36	regulation of cell maturation (GO:1903429)	3.86472653
37	production of molecular mediator involved in inflammatory response (GO:0002532)	3.86368451
38	glomerular filtration (GO:0003094)	3.81786886
39	positive regulation of calcium-mediated signaling (GO:0050850)	3.80018674
40	regulation of histone H3-K9 methylation (GO:0051570)	3.76283817
41	cilium or flagellum-dependent cell motility (GO:0001539)	3.74492909
42	piRNA metabolic process (GO:0034587)	3.73739809
43	columnar/cuboidal epithelial cell development (GO:0002066)	3.72361302
44	serotonin metabolic process (GO:0042428)	3.63419049
45	embryonic eye morphogenesis (GO:0048048)	3.63199919
46	synapsis (GO:0007129)	3.62364922
47	positive regulation of cAMP-mediated signaling (GO:0043950)	3.60791101
48	cytolysis (GO:0019835)	3.60299993
49	glomerular basement membrane development (GO:0032836)	3.50955046
50	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.48559323
51	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.47701183
52	positive regulation of tolerance induction (GO:0002645)	3.44265114
53	cysteine metabolic process (GO:0006534)	3.38842480
54	cellular response to ATP (GO:0071318)	3.37657059
55	regulation of interleukin-2 biosynthetic process (GO:0045076)	3.37428356
56	regulation of prostaglandin secretion (GO:0032306)	3.31737940
57	renal filtration (GO:0097205)	3.26548681
58	positive regulation of calcium ion transport into cytosol (GO:0010524)	3.20899148
59	amino sugar catabolic process (GO:0046348)	3.20517923
60	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.16223839
61	regulation of acrosome reaction (GO:0060046)	3.16025796
62	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.15946814
63	interkinetic nuclear migration (GO:0022027)	3.14989469
64	behavioral response to nicotine (GO:0035095)	3.13214482
65	centriole replication (GO:0007099)	3.11087623
66	meiotic cell cycle (GO:0051321)	3.09887064
67	regulation of myelination (GO:0031641)	3.05030746
68	negative regulation of telomere maintenance (GO:0032205)	3.03622430
69	cardiocyte differentiation (GO:0035051)	2.99589534
70	primary amino compound metabolic process (GO:1901160)	2.99041166
71	DNA deamination (GO:0045006)	2.98268273
72	negative regulation of cardiac muscle hypertrophy (GO:0010614)	2.97847554
73	multicellular organism reproduction (GO:0032504)	2.97234913
74	oocyte development (GO:0048599)	2.97201114
75	regulation of T cell tolerance induction (GO:0002664)	2.94087511
76	positive regulation of fatty acid transport (GO:2000193)	2.92104846
77	positive regulation of smooth muscle contraction (GO:0045987)	2.89880250
78	positive regulation of protein kinase C signaling (GO:0090037)	2.89111328
79	thymic T cell selection (GO:0045061)	2.86785798
80	negative regulation of reproductive process (GO:2000242)	2.86712715
81	positive regulation of icosanoid secretion (GO:0032305)	2.86321697
82	regulation of chemokine-mediated signaling pathway (GO:0070099)	2.86023645
83	positive regulation of gamma-delta T cell activation (GO:0046645)	2.85953359
84	negative thymic T cell selection (GO:0045060)	2.85870021
85	regulation of gamma-delta T cell differentiation (GO:0045586)	2.84525219
86	phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200)	2.83182578
87	regulation of penile erection (GO:0060405)	2.82819337
88	signal complex assembly (GO:0007172)	2.82418030
89	meiosis I (GO:0007127)	2.81334103
90	regulation of cAMP-mediated signaling (GO:0043949)	2.78251397
91	gene silencing by RNA (GO:0031047)	2.77552260
92	intestinal cholesterol absorption (GO:0030299)	2.75956020
93	positive regulation of interleukin-17 production (GO:0032740)	2.75693706
94	dopamine biosynthetic process (GO:0042416)	2.75424495
95	DNA methylation involved in gamete generation (GO:0043046)	2.74785833
96	photoreceptor cell maintenance (GO:0045494)	2.73759899
97	response to misfolded protein (GO:0051788)	2.73504199
98	cerebral cortex neuron differentiation (GO:0021895)	2.72413020
99	female gamete generation (GO:0007292)	2.71416646
100	nucleoside transmembrane transport (GO:1901642)	10.3347619

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	8.50126992
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	7.65037845
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	5.50710571
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.20624471
5	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	4.00898070
6	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.50269213
7	GBX2_23144817_ChIP-Seq_PC3_Human	3.25540271
8	ZNF274_21170338_ChIP-Seq_K562_Hela	3.02257795
9	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.97985848
10	VDR_22108803_ChIP-Seq_LS180_Human	2.76548191
11	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.57066363
12	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.10241155
13	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.06806533
14	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	2.06333199
15	DROSHA_22980978_ChIP-Seq_HELA_Human	1.94086298
16	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.74324276
17	IRF1_19129219_ChIP-ChIP_H3396_Human	1.73943372
18	BCAT_22108803_ChIP-Seq_LS180_Human	1.73529957
19	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.67257487
20	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.67028904
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.64481621
22	NANOG_20526341_ChIP-Seq_ESCs_Human	1.57752868
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.44970069
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.44373503
25	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.42118667
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.42118442
27	AR_20517297_ChIP-Seq_VCAP_Human	1.33318288
28	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30506475
29	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.26991087
30	TAF2_19829295_ChIP-Seq_ESCs_Human	1.26844325
31	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.25739403
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.25414784
33	ERG_20517297_ChIP-Seq_VCAP_Human	1.23917657
34	AR_25329375_ChIP-Seq_VCAP_Human	1.22656862
35	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.20070276
36	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.19093735
37	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.18521423
38	TAF15_26573619_Chip-Seq_HEK293_Human	1.17452972
39	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.17125505
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16663568
41	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.16617270
42	RUNX_20019798_ChIP-Seq_JUKART_Human	1.15990318
43	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.15068357
44	TCF4_23295773_ChIP-Seq_U87_Human	1.14534589
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.13694702
46	OCT4_20526341_ChIP-Seq_ESCs_Human	1.12770672
47	GATA1_22025678_ChIP-Seq_K562_Human	1.12503465
48	ERA_21632823_ChIP-Seq_H3396_Human	1.11231673
49	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.11175701
50	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.11044226
51	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.09750270
52	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.08163694
53	STAT3_23295773_ChIP-Seq_U87_Human	1.07250403
54	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.06423140
55	NCOR_22424771_ChIP-Seq_293T_Human	1.06354604
56	EWS_26573619_Chip-Seq_HEK293_Human	1.06047536
57	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.06037778
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04841034
59	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04841034
60	P53_21459846_ChIP-Seq_SAOS-2_Human	1.02993429
61	AHR_22903824_ChIP-Seq_MCF-7_Human	1.01786620
62	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00380856
63	RXR_22108803_ChIP-Seq_LS180_Human	0.99862772
64	SCL_19346495_ChIP-Seq_HPC-7_Human	0.99071900
65	CTCF_20526341_ChIP-Seq_ESCs_Human	0.98663584
66	HTT_18923047_ChIP-ChIP_STHdh_Human	0.98288827
67	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.98277110
68	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.97688484
69	GATA3_26560356_Chip-Seq_TH1_Human	0.97597466
70	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.97065930
71	TCF4_22108803_ChIP-Seq_LS180_Human	0.97013106
72	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.96045777
73	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.95207066
74	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.94308240
75	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.94249600
76	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.93794017
77	P300_19829295_ChIP-Seq_ESCs_Human	0.93067467
78	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.89801156
79	NANOG_19829295_ChIP-Seq_ESCs_Human	0.89570290
80	SOX2_19829295_ChIP-Seq_ESCs_Human	0.89570290
81	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.89527505
82	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.89189960
83	HOXB7_26014856_ChIP-Seq_BT474_Human	0.88040518
84	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.86814371
85	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.84442926
86	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.83463957
87	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.82971071
88	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.82930937
89	MYC_19829295_ChIP-Seq_ESCs_Human	0.81442100
90	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.79783447
91	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.79584110
92	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.78928045
93	JUN_21703547_ChIP-Seq_K562_Human	0.78778430
94	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.78281684
95	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.77656136
96	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.77330731
97	REST_21632747_ChIP-Seq_MESCs_Mouse	0.76998233
98	SPI1_20517297_ChIP-Seq_HL60_Human	0.76407444
99	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.76405690
100	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.76153707

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010030_abnormal_orbit_morphology	9.70723023
2	MP0005248_abnormal_Harderian_gland	6.06545873
3	MP0002249_abnormal_larynx_morphology	3.42300873
4	MP0003880_abnormal_central_pattern	3.30547448
5	MP0003718_maternal_effect	3.24885007
6	MP0002102_abnormal_ear_morphology	3.21029013
7	MP0005377_hearing/vestibular/ear_phenot	2.72557594
8	MP0003878_abnormal_ear_physiology	2.72557594
9	MP0000613_abnormal_salivary_gland	2.52137659
10	MP0009840_abnormal_foam_cell	2.51117489
11	MP0002282_abnormal_trachea_morphology	2.48545936
12	MP0003136_yellow_coat_color	2.48493149
13	MP0005671_abnormal_response_to	2.45270678
14	MP0002653_abnormal_ependyma_morphology	2.38111427
15	MP0003879_abnormal_hair_cell	2.36194512
16	MP0003045_fibrosis	2.15987905
17	MP0005083_abnormal_biliary_tract	2.08858991
18	MP0001984_abnormal_olfaction	1.83452489
19	MP0005395_other_phenotype	1.83276045
20	MP0000534_abnormal_ureter_morphology	1.82119837
21	MP0008057_abnormal_DNA_replication	1.81841255
22	MP0005171_absent_coat_pigmentation	1.77947176
23	MP0001661_extended_life_span	1.74354053
24	MP0009379_abnormal_foot_pigmentation	1.70520507
25	MP0004885_abnormal_endolymph	1.60590399
26	MP0005551_abnormal_eye_electrophysiolog	1.50515266
27	MP0005197_abnormal_uvea_morphology	1.49401546
28	MP0003866_abnormal_defecation	1.45981316
29	MP0009785_altered_susceptibility_to	1.32712966
30	MP0003890_abnormal_embryonic-extraembry	1.29499834
31	MP0003950_abnormal_plasma_membrane	1.23014519
32	MP0002138_abnormal_hepatobiliary_system	1.17818109
33	MP0003011_delayed_dark_adaptation	1.16866173
34	MP0010368_abnormal_lymphatic_system	1.15258086
35	MP0003959_abnormal_lean_body	1.14981618
36	MP0004742_abnormal_vestibular_system	1.10117963
37	MP0002233_abnormal_nose_morphology	1.09257247
38	MP0001835_abnormal_antigen_presentation	1.04119124
39	MP0005508_abnormal_skeleton_morphology	1.02910542
40	MP0002932_abnormal_joint_morphology	1.02589370
41	MP0005410_abnormal_fertilization	1.01667283
42	MP0002876_abnormal_thyroid_physiology	1.01561182
43	MP0000647_abnormal_sebaceous_gland	0.98135371
44	MP0003195_calcinosis	0.97563754
45	MP0001485_abnormal_pinna_reflex	0.95305072
46	MP0001929_abnormal_gametogenesis	0.94241871
47	MP0005645_abnormal_hypothalamus_physiol	0.93018491
48	MP0005595_abnormal_vascular_smooth	0.92901116
49	MP0001905_abnormal_dopamine_level	0.92478401
50	MP0002210_abnormal_sex_determination	0.89964732
51	MP0002168_other_aberrant_phenotype	0.89473629
52	MP0000678_abnormal_parathyroid_gland	0.88768064
53	MP0003329_amyloid_beta_deposits	0.84353798
54	MP0005389_reproductive_system_phenotype	0.83424258
55	MP0000685_abnormal_immune_system	0.82261159
56	MP0002160_abnormal_reproductive_system	0.80928321
57	MP0004134_abnormal_chest_morphology	0.79335455
58	MP0006292_abnormal_olfactory_placode	0.78120445
59	MP0005332_abnormal_amino_acid	0.76634205
60	MP0005174_abnormal_tail_pigmentation	0.75330726
61	MP0008877_abnormal_DNA_methylation	0.75057821
62	MP0003111_abnormal_nucleus_morphology	0.70636472
63	MP0000230_abnormal_systemic_arterial	0.70310583
64	MP0001529_abnormal_vocalization	0.70287977
65	MP0000026_abnormal_inner_ear	0.69115807
66	MP0005647_abnormal_sex_gland	0.68242490
67	MP0000163_abnormal_cartilage_morphology	0.67886338
68	MP0003699_abnormal_female_reproductive	0.67787060
69	MP0005334_abnormal_fat_pad	0.64566486
70	MP0004142_abnormal_muscle_tone	0.64175190
71	MP0001986_abnormal_taste_sensitivity	0.63197205
72	MP0005253_abnormal_eye_physiology	0.62884569
73	MP0002234_abnormal_pharynx_morphology	0.61896426
74	MP0002272_abnormal_nervous_system	0.61618282
75	MP0006138_congestive_heart_failure	0.60295719
76	MP0003283_abnormal_digestive_organ	0.59937010
77	MP0005266_abnormal_metabolism	0.59617264
78	MP0005365_abnormal_bile_salt	0.59506152
79	MP0001764_abnormal_homeostasis	0.58689023
80	MP0002405_respiratory_system_inflammati	0.57908328
81	MP0001919_abnormal_reproductive_system	0.57490116
82	MP0006276_abnormal_autonomic_nervous	0.55956190
83	MP0001970_abnormal_pain_threshold	0.55788627
84	MP0002733_abnormal_thermal_nociception	0.53619953
85	MP0008872_abnormal_physiological_respon	0.53447746
86	MP0006036_abnormal_mitochondrial_physio	0.52631863
87	MP0001286_abnormal_eye_development	0.52437279
88	MP0001486_abnormal_startle_reflex	0.52309340
89	MP0001664_abnormal_digestion	0.51585574
90	MP0003252_abnormal_bile_duct	0.51431022
91	MP0003632_abnormal_nervous_system	0.50945449
92	MP0005360_urolithiasis	0.50418235
93	MP0003698_abnormal_male_reproductive	0.50160100
94	MP0009643_abnormal_urine_homeostasis	0.49518611
95	MP0002420_abnormal_adaptive_immunity	0.48972736
96	MP0001963_abnormal_hearing_physiology	0.48826554
97	MP0002752_abnormal_somatic_nervous	0.48778067
98	MP0000427_abnormal_hair_cycle	0.47228887
99	MP0002161_abnormal_fertility/fecundity	0.47188554
100	MP0002751_abnormal_autonomic_nervous	0.46451972

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Bicornuate uterus (HP:0000813)	6.75130387
2	Male infertility (HP:0003251)	5.58113671
3	Hypophosphatemic rickets (HP:0004912)	5.57716149
4	Abnormal lung lobation (HP:0002101)	5.19952837
5	Anophthalmia (HP:0000528)	5.18761734
6	Congenital sensorineural hearing impairment (HP:0008527)	4.45832087
7	Recurrent corneal erosions (HP:0000495)	4.43553732
8	Generalized aminoaciduria (HP:0002909)	4.31235048
9	Aplastic anemia (HP:0001915)	4.30707564
10	Attenuation of retinal blood vessels (HP:0007843)	4.11107924
11	Tubular atrophy (HP:0000092)	4.08905208
12	Small intestinal stenosis (HP:0012848)	4.05925131
13	Duodenal stenosis (HP:0100867)	4.05925131
14	Abnormal drinking behavior (HP:0030082)	4.03059853
15	Polydipsia (HP:0001959)	4.03059853
16	Spastic paraparesis (HP:0002313)	3.42094020
17	Pancreatic cysts (HP:0001737)	3.18443410
18	Abnormality of the duodenum (HP:0002246)	3.18262358
19	Polyuria (HP:0000103)	3.16236646
20	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.10762340
21	Broad nasal tip (HP:0000455)	3.06277204
22	Abnormality of glycolipid metabolism (HP:0010969)	3.01295172
23	Abnormality of liposaccharide metabolism (HP:0010968)	3.01295172
24	Abnormality of glycosphingolipid metabolism (HP:0004343)	3.01295172
25	Abnormality of alanine metabolism (HP:0010916)	2.88994951
26	Hyperalaninemia (HP:0003348)	2.88994951
27	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.88994951
28	Mesangial abnormality (HP:0001966)	2.85732972
29	Abnormal urine output (HP:0012590)	2.63306969
30	T lymphocytopenia (HP:0005403)	2.62789901
31	Abnormality of T cell number (HP:0011839)	2.59455543
32	Stomatitis (HP:0010280)	2.58091052
33	Facial hemangioma (HP:0000329)	2.55812718
34	Abnormality of midbrain morphology (HP:0002418)	2.54247969
35	Molar tooth sign on MRI (HP:0002419)	2.54247969
36	Epidermoid cyst (HP:0200040)	2.53679133
37	Lip pit (HP:0100267)	2.53504286
38	Amyotrophic lateral sclerosis (HP:0007354)	2.49381128
39	Abnormality of the renal cortex (HP:0011035)	2.48274938
40	Medial flaring of the eyebrow (HP:0010747)	2.46116266
41	Infertility (HP:0000789)	2.42226500
42	Hyponatremia (HP:0002902)	2.37388627
43	Horizontal nystagmus (HP:0000666)	2.35055715
44	Genetic anticipation (HP:0003743)	2.34687684
45	Abnormal respiratory motile cilium physiology (HP:0012261)	2.34045490
46	Toxemia of pregnancy (HP:0100603)	2.33399250
47	Hypokalemia (HP:0002900)	2.33026222
48	Tubulointerstitial fibrosis (HP:0005576)	2.26026429
49	Rickets (HP:0002748)	2.26000773
50	Abnormality of the costochondral junction (HP:0000919)	2.25831878
51	Abnormality of renal excretion (HP:0011036)	2.23603388
52	Corneal erosion (HP:0200020)	2.07865483
53	Congenital primary aphakia (HP:0007707)	2.02605851
54	Hypoproteinemia (HP:0003075)	2.02484480
55	Renal Fanconi syndrome (HP:0001994)	2.02289820
56	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.01724572
57	Focal dystonia (HP:0004373)	2.01592574
58	Abnormal pancreas size (HP:0012094)	10.3352193
59	Annular pancreas (HP:0001734)	10.1343406
60	Progressive cerebellar ataxia (HP:0002073)	1.98761494
61	Hydroxyprolinuria (HP:0003080)	1.98104021
62	Abnormality of proline metabolism (HP:0010907)	1.98104021
63	Increased IgM level (HP:0003496)	1.95620885
64	Craniofacial dystonia (HP:0012179)	1.95320049
65	Gait imbalance (HP:0002141)	1.95117262
66	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.94124822
67	Abnormality of DNA repair (HP:0003254)	1.93069329
68	Supernumerary spleens (HP:0009799)	1.90291029
69	Abnormality of potassium homeostasis (HP:0011042)	1.90272982
70	Rhinitis (HP:0012384)	1.88882400
71	Type I diabetes mellitus (HP:0100651)	1.87872378
72	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.87694815
73	Paraparesis (HP:0002385)	1.85533024
74	Abnormal ciliary motility (HP:0012262)	1.83666470
75	Decreased circulating renin level (HP:0003351)	1.83372531
76	Abnormal auditory evoked potentials (HP:0006958)	1.82784737
77	Bronchiectasis (HP:0002110)	1.81216337
78	Torticollis (HP:0000473)	1.80226062
79	Anterior segment dysgenesis (HP:0007700)	1.80179783
80	Failure to thrive in infancy (HP:0001531)	1.77141325
81	Osteomalacia (HP:0002749)	1.76967786
82	Abnormality of sodium homeostasis (HP:0010931)	1.74717331
83	Poor coordination (HP:0002370)	1.74602273
84	Exocrine pancreatic insufficiency (HP:0001738)	1.74164598
85	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.73562070
86	Photophobia (HP:0000613)	1.73278404
87	Pulmonary hypoplasia (HP:0002089)	1.72761875
88	Nephrogenic diabetes insipidus (HP:0009806)	1.69498727
89	Stomach cancer (HP:0012126)	1.66614932
90	Abnormality of dental color (HP:0011073)	1.66168221
91	Polycythemia (HP:0001901)	1.66035061
92	Metabolic alkalosis (HP:0200114)	1.63554452
93	Neonatal respiratory distress (HP:0002643)	1.63435279
94	Tubulointerstitial abnormality (HP:0001969)	1.62210359
95	Median cleft lip (HP:0000161)	1.61258211
96	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.59839571
97	Abnormality of the renal medulla (HP:0100957)	1.57755776
98	Hypoplasia of the uterus (HP:0000013)	1.53780566
99	Cystic liver disease (HP:0006706)	1.53641363
100	Nasal polyposis (HP:0100582)	1.52582611

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K1	5.76213205
2	MAPKAPK3	3.68107362
3	KDR	3.61811406
4	PINK1	3.52127680
5	NME1	3.23997735
6	TAOK3	2.82597076
7	SCYL2	2.64267843
8	TNIK	2.45756131
9	TYRO3	2.38871987
10	TESK2	2.27185435
11	TEC	2.17559962
12	ACVR1B	2.17070894
13	ADRBK2	2.13203442
14	PIK3CG	2.10446690
15	MAP3K5	2.06752885
16	MAP3K9	2.02468454
17	WNK4	1.92547365
18	TLK1	1.79460209
19	PRKCQ	1.64349323
20	MAP3K13	1.63593555
21	BMPR1B	1.62916781
22	NEK6	1.61534695
23	MAP3K11	1.58816523
24	STK24	1.52480302
25	CAMKK2	1.44620925
26	ADRBK1	1.39825073
27	MAP3K12	1.35268637
28	CAMKK1	1.29959938
29	TAOK2	1.25390299
30	TRPM7	1.21042876
31	ITK	1.20214834
32	BRSK2	1.16268254
33	ARAF	1.12552375
34	WNK1	1.06345248
35	PTK2B	1.04654964
36	NTRK3	1.02129248
37	CSF1R	1.01262979
38	NEK2	0.99418761
39	MET	0.98818666
40	MAP3K7	0.92074484
41	MELK	0.88653962
42	AURKA	0.87150787
43	SYK	0.84443383
44	TGFBR1	0.84282878
45	BTK	0.84266503
46	TTK	0.81834675
47	GRK6	0.79290112
48	GRK1	0.79122687
49	DYRK2	0.78331172
50	NTRK2	0.77813009
51	MAPK15	0.75897298
52	LIMK1	0.74101652
53	STK10	0.70324354
54	ZAK	0.69907664
55	MOS	0.69721108
56	MAPK13	0.68910757
57	MAP3K1	0.66985732
58	MAP3K4	0.66926589
59	LCK	0.66886263
60	MAP4K2	0.64390408
61	INSRR	0.63971760
62	IGF1R	0.61951674
63	PASK	0.57161622
64	BRSK1	0.56239793
65	CHEK2	0.55551301
66	EPHA3	0.54453939
67	PIM1	0.54252602
68	IRAK4	0.52747168
69	MATK	0.51347033
70	LMTK2	0.49168032
71	ROCK1	0.47335912
72	SIK2	0.44671117
73	INSR	0.44079015
74	CAMK2A	0.43643821
75	MARK3	0.43483103
76	CSK	0.37251199
77	ZAP70	0.37227632
78	TESK1	0.36397697
79	MAP3K8	0.36310869
80	MUSK	0.34215457
81	PRKG1	0.33278844
82	DAPK1	0.31496149
83	PLK4	0.30140765
84	DYRK1A	0.29818934
85	MST1R	0.29799633
86	ERBB2	0.29510128
87	TIE1	0.29448248
88	KSR2	0.28745889
89	CSNK1G2	0.28744300
90	BCKDK	0.28602782
91	PDK1	0.27761179
92	HCK	0.27548614
93	PLK1	0.27103134
94	BRAF	0.26293494
95	BMPR2	0.26061054
96	FRK	0.25016600
97	DYRK3	0.23776490
98	ATR	0.23123917
99	PRKACA	0.23024891
100	RIPK4	0.22905213

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	5.80188823
2	Selenocompound metabolism_Homo sapiens_hsa00450	4.29283305
3	Phototransduction_Homo sapiens_hsa04744	3.69836778
4	T cell receptor signaling pathway_Homo sapiens_hsa04660	2.63217927
5	Olfactory transduction_Homo sapiens_hsa04740	2.38225549
6	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.32367144
7	Ovarian steroidogenesis_Homo sapiens_hsa04913	2.19904742
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.16953054
9	Antigen processing and presentation_Homo sapiens_hsa04612	2.10080758
10	Nicotine addiction_Homo sapiens_hsa05033	2.01908751
11	Sulfur relay system_Homo sapiens_hsa04122	1.84377353
12	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.55330849
13	ABC transporters_Homo sapiens_hsa02010	1.52768006
14	Steroid biosynthesis_Homo sapiens_hsa00100	1.48377090
15	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.46566778
16	Non-small cell lung cancer_Homo sapiens_hsa05223	1.45949480
17	Basal transcription factors_Homo sapiens_hsa03022	1.45145952
18	Salivary secretion_Homo sapiens_hsa04970	1.42429449
19	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.35828310
20	Morphine addiction_Homo sapiens_hsa05032	1.32345719
21	African trypanosomiasis_Homo sapiens_hsa05143	1.32179790
22	Oocyte meiosis_Homo sapiens_hsa04114	1.31212766
23	Mismatch repair_Homo sapiens_hsa03430	1.28869021
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.28352260
25	Taste transduction_Homo sapiens_hsa04742	1.27264331
26	Calcium signaling pathway_Homo sapiens_hsa04020	1.26006901
27	Homologous recombination_Homo sapiens_hsa03440	1.20339994
28	Bile secretion_Homo sapiens_hsa04976	1.19766624
29	Caffeine metabolism_Homo sapiens_hsa00232	1.19346802
30	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.17411694
31	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.15962215
32	RNA polymerase_Homo sapiens_hsa03020	1.15773563
33	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.12645081
34	Linoleic acid metabolism_Homo sapiens_hsa00591	1.12539075
35	GABAergic synapse_Homo sapiens_hsa04727	1.11256154
36	Insulin secretion_Homo sapiens_hsa04911	1.03308958
37	Cell cycle_Homo sapiens_hsa04110	1.02424781
38	Nucleotide excision repair_Homo sapiens_hsa03420	1.01257486
39	Malaria_Homo sapiens_hsa05144	0.98700907
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.96926797
41	Circadian entrainment_Homo sapiens_hsa04713	0.93418623
42	Base excision repair_Homo sapiens_hsa03410	0.88669992
43	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.87838062
44	Cocaine addiction_Homo sapiens_hsa05030	0.87762042
45	Amphetamine addiction_Homo sapiens_hsa05031	0.84920789
46	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.82543349
47	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.82203379
48	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.81854102
49	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.80237837
50	Cardiac muscle contraction_Homo sapiens_hsa04260	0.79907589
51	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.79393511
52	Histidine metabolism_Homo sapiens_hsa00340	0.78728155
53	Gastric acid secretion_Homo sapiens_hsa04971	0.77991684
54	Tryptophan metabolism_Homo sapiens_hsa00380	0.76665813
55	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.76273204
56	Purine metabolism_Homo sapiens_hsa00230	0.75793156
57	Measles_Homo sapiens_hsa05162	0.72262290
58	Regulation of autophagy_Homo sapiens_hsa04140	0.70232686
59	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.69642221
60	RNA degradation_Homo sapiens_hsa03018	0.68760956
61	Small cell lung cancer_Homo sapiens_hsa05222	0.67924122
62	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.66413779
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.64859345
64	Parkinsons disease_Homo sapiens_hsa05012	0.64765725
65	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.63344962
66	Oxidative phosphorylation_Homo sapiens_hsa00190	0.63168711
67	Serotonergic synapse_Homo sapiens_hsa04726	0.62468701
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.59534462
69	Mineral absorption_Homo sapiens_hsa04978	0.53952983
70	Shigellosis_Homo sapiens_hsa05131	0.52065720
71	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.51940905
72	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.49849724
73	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.47973858
74	Glutamatergic synapse_Homo sapiens_hsa04724	0.47052442
75	Cholinergic synapse_Homo sapiens_hsa04725	0.47030727
76	Complement and coagulation cascades_Homo sapiens_hsa04610	0.46287562
77	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.45821472
78	Rap1 signaling pathway_Homo sapiens_hsa04015	0.45625454
79	Retinol metabolism_Homo sapiens_hsa00830	0.45111541
80	Chemokine signaling pathway_Homo sapiens_hsa04062	0.42581462
81	Platelet activation_Homo sapiens_hsa04611	0.41987592
82	Pancreatic secretion_Homo sapiens_hsa04972	0.40387972
83	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.39403881
84	One carbon pool by folate_Homo sapiens_hsa00670	0.37941875
85	Dopaminergic synapse_Homo sapiens_hsa04728	0.37101850
86	Fanconi anemia pathway_Homo sapiens_hsa03460	0.35919503
87	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.35715708
88	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.34576016
89	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.34250076
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.32043850
91	DNA replication_Homo sapiens_hsa03030	0.29074130
92	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.28454185
93	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.27977860
94	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.27100961
95	Graft-versus-host disease_Homo sapiens_hsa05332	0.25663155
96	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.24743774
97	Allograft rejection_Homo sapiens_hsa05330	0.24681626
98	Huntingtons disease_Homo sapiens_hsa05016	0.24623956
99	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.24321205
100	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.23051087

OR4F7P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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