ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	8.02993152
2	DNA topological change (GO:0006265)	7.73176107
3	sensory perception of smell (GO:0007608)	6.52551519
4	regulation of memory T cell differentiation (GO:0043380)	5.41079516
5	purine nucleobase biosynthetic process (GO:0009113)	5.29625349
6	detection of chemical stimulus involved in sensory perception (GO:0050907)	5.21827426
7	nuclear pore complex assembly (GO:0051292)	4.99744820
8	resolution of meiotic recombination intermediates (GO:0000712)	4.87513061
9	replication fork processing (GO:0031297)	4.85334456
10	centriole replication (GO:0007099)	4.84665161
11	DNA replication checkpoint (GO:0000076)	4.81739077
12	nucleobase biosynthetic process (GO:0046112)	4.60160179
13	cellular ketone body metabolic process (GO:0046950)	4.58204080
14	meiotic chromosome segregation (GO:0045132)	4.54315175
15	synapsis (GO:0007129)	4.51821790
16	nuclear pore organization (GO:0006999)	4.33443656
17	protoporphyrinogen IX metabolic process (GO:0046501)	4.22045098
18	pore complex assembly (GO:0046931)	4.14381964
19	protoporphyrinogen IX biosynthetic process (GO:0006782)	4.14313771
20	folic acid metabolic process (GO:0046655)	4.13904060
21	DNA strand renaturation (GO:0000733)	4.11014515
22	signal peptide processing (GO:0006465)	4.05348827
23	diterpenoid biosynthetic process (GO:0016102)	4.03930431
24	ketone body metabolic process (GO:1902224)	4.03822101
25	regulation of histone H3-K4 methylation (GO:0051569)	4.03588093
26	DNA synthesis involved in DNA repair (GO:0000731)	4.01049920
27	erythrocyte development (GO:0048821)	4.00949710
28	DNA replication initiation (GO:0006270)	3.90251725
29	terpenoid biosynthetic process (GO:0016114)	3.89798254
30	rRNA methylation (GO:0031167)	3.72698099
31	detection of chemical stimulus (GO:0009593)	3.65101053
32	pyrimidine dimer repair (GO:0006290)	3.64016982
33	sensory perception of chemical stimulus (GO:0007606)	3.60628703
34	regulation of centriole replication (GO:0046599)	3.58465293
35	mitotic nuclear envelope disassembly (GO:0007077)	3.53951630
36	centriole assembly (GO:0098534)	3.50086959
37	tetrahydrofolate metabolic process (GO:0046653)	3.46800927
38	cell wall macromolecule catabolic process (GO:0016998)	3.45050447
39	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.41707443
40	kinetochore organization (GO:0051383)	3.37981726
41	negative regulation of phosphoprotein phosphatase activity (GO:0032515)	3.37930454
42	kinetochore assembly (GO:0051382)	3.37360073
43	regulation of activation of Janus kinase activity (GO:0010533)	3.36263990
44	granulocyte differentiation (GO:0030851)	3.33743494
45	IMP biosynthetic process (GO:0006188)	3.31121195
46	tRNA aminoacylation for protein translation (GO:0006418)	3.29761398
47	rRNA modification (GO:0000154)	3.28525045
48	reciprocal DNA recombination (GO:0035825)	3.26736641
49	reciprocal meiotic recombination (GO:0007131)	3.26736641
50	regulation of translational fidelity (GO:0006450)	3.23961344
51	membrane disassembly (GO:0030397)	3.21883299
52	nuclear envelope disassembly (GO:0051081)	3.21883299
53	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.12846939
54	amino acid activation (GO:0043038)	3.12300445
55	tRNA aminoacylation (GO:0043039)	3.12300445
56	mitotic sister chromatid segregation (GO:0000070)	3.09499864
57	positive regulation of histone H3-K4 methylation (GO:0051571)	3.08947329
58	COPI coating of Golgi vesicle (GO:0048205)	3.08146705
59	Golgi transport vesicle coating (GO:0048200)	3.08146705
60	recombinational repair (GO:0000725)	3.07899989
61	double-strand break repair via homologous recombination (GO:0000724)	3.07375277
62	ribosomal small subunit assembly (GO:0000028)	3.07256324
63	positive regulation of interleukin-17 production (GO:0032740)	3.06284993
64	DNA unwinding involved in DNA replication (GO:0006268)	3.05510552
65	chromosome segregation (GO:0007059)	3.03260883
66	methionine biosynthetic process (GO:0009086)	3.02160426
67	S-adenosylmethionine metabolic process (GO:0046500)	3.01051050
68	sister chromatid segregation (GO:0000819)	2.99605015
69	definitive hemopoiesis (GO:0060216)	2.96797535
70	chromosome organization involved in meiosis (GO:0070192)	2.94220653
71	erythrocyte maturation (GO:0043249)	2.93290071
72	aspartate family amino acid biosynthetic process (GO:0009067)	2.92856582
73	male meiosis I (GO:0007141)	2.92581527
74	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	2.92313741
75	mitochondrial RNA metabolic process (GO:0000959)	2.92147474
76	telomere maintenance via semi-conservative replication (GO:0032201)	2.91588084
77	viral mRNA export from host cell nucleus (GO:0046784)	2.90774219
78	folic acid-containing compound metabolic process (GO:0006760)	2.89408470
79	proteasome assembly (GO:0043248)	2.87542160
80	gas transport (GO:0015669)	2.86603093
81	cell wall macromolecule metabolic process (GO:0044036)	2.85984897
82	mitotic recombination (GO:0006312)	2.85368671
83	piRNA metabolic process (GO:0034587)	2.83026319
84	negative regulation of DNA recombination (GO:0045910)	2.81124577
85	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.81116889
86	ribosome biogenesis (GO:0042254)	2.81014124
87	poly(A)+ mRNA export from nucleus (GO:0016973)	2.80501191
88	regulation of retinoic acid receptor signaling pathway (GO:0048385)	2.73489939
89	regulation of translation in response to stress (GO:0043555)	2.71248123
90	mast cell activation involved in immune response (GO:0002279)	2.70729895
91	mast cell degranulation (GO:0043303)	2.70729895
92	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	2.69325349
93	DNA strand elongation involved in DNA replication (GO:0006271)	2.69258216
94	homocysteine metabolic process (GO:0050667)	2.68966577
95	telomere maintenance via recombination (GO:0000722)	2.67952322
96	IMP metabolic process (GO:0046040)	2.64632282
97	DNA conformation change (GO:0071103)	2.62475270
98	protein K11-linked deubiquitination (GO:0035871)	2.60972185
99	response to vitamin A (GO:0033189)	2.60893982
100	regulation of histone H3-K9 methylation (GO:0051570)	2.60483249

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.69968275
2	VDR_22108803_ChIP-Seq_LS180_Human	6.10395097
3	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.96490630
4	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.84619614
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.59593003
6	GATA1_22025678_ChIP-Seq_K562_Human	3.56156695
7	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.33810906
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.67941888
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.57440037
10	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.51374776
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.44565245
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.38770219
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.33248739
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.27397484
15	GATA1_19941826_ChIP-Seq_K562_Human	2.22418236
16	NCOR1_26117541_ChIP-Seq_K562_Human	2.21549733
17	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.13445471
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.12865220
19	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.05347673
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.01340739
21	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.97203877
22	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.93172602
23	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.83881889
24	KDM5A_27292631_Chip-Seq_BREAST_Human	1.77255841
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.76202447
26	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.72227559
27	GATA2_19941826_ChIP-Seq_K562_Human	1.70191550
28	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.64366583
29	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.64008381
30	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.61496447
31	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.59717501
32	ELK1_19687146_ChIP-ChIP_HELA_Human	1.59461004
33	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.56091556
34	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.49995486
35	DCP1A_22483619_ChIP-Seq_HELA_Human	1.49812802
36	PHF8_20622853_ChIP-Seq_HELA_Human	1.49177134
37	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.48676246
38	ER_23166858_ChIP-Seq_MCF-7_Human	1.45169076
39	VDR_23849224_ChIP-Seq_CD4+_Human	1.45091017
40	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.44031585
41	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.40761468
42	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.38711001
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.38612272
44	SCL_19346495_ChIP-Seq_HPC-7_Human	1.38601094
45	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.38388234
46	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.37887698
47	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.36977753
48	XRN2_22483619_ChIP-Seq_HELA_Human	1.36054307
49	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.33846163
50	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.33812473
51	SPI1_23127762_ChIP-Seq_K562_Human	1.33493430
52	EWS_26573619_Chip-Seq_HEK293_Human	1.32502357
53	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.31250860
54	FOXP3_21729870_ChIP-Seq_TREG_Human	1.29664879
55	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.28993836
56	TTF2_22483619_ChIP-Seq_HELA_Human	1.28547655
57	IGF1R_20145208_ChIP-Seq_DFB_Human	1.28381458
58	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.27057342
59	RBPJ_21746931_ChIP-Seq_IB4_Human	1.26983117
60	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.26813205
61	ETV1_20927104_ChIP-Seq_GIST48_Human	1.26684511
62	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.26161785
63	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.24311579
64	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.24090359
65	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.23284443
66	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.20344769
67	NFYB_21822215_ChIP-Seq_K562_Human	1.19603611
68	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.17289510
69	CIITA_25753668_ChIP-Seq_RAJI_Human	1.15096451
70	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.14765263
71	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.14022943
72	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.12113850
73	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.11709536
74	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.09327192
75	GABP_19822575_ChIP-Seq_HepG2_Human	1.08403672
76	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.08384808
77	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.00473805
78	ZNF274_21170338_ChIP-Seq_K562_Hela	1.00407193
79	NFYA_21822215_ChIP-Seq_K562_Human	0.99884136
80	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.98419594
81	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.97134886
82	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.96739793
83	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.94930602
84	EGR1_19032775_ChIP-ChIP_M12_Human	0.94775112
85	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.92919288
86	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.92192735
87	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.89168032
88	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.87644864
89	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.86294857
90	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.83498161
91	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.83461341
92	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.83254231
93	TP53_22573176_ChIP-Seq_HFKS_Human	0.83047861
94	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.82881071
95	P53_21459846_ChIP-Seq_SAOS-2_Human	0.82556599
96	HTT_18923047_ChIP-ChIP_STHdh_Human	0.82279872
97	TBL1_22424771_ChIP-Seq_293T_Human	0.80653432
98	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.79650002
99	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.79377227
100	JUN_21703547_ChIP-Seq_K562_Human	0.79173551

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008995_early_reproductive_senescence	5.20993558
2	MP0004147_increased_porphyrin_level	4.55051273
3	MP0008058_abnormal_DNA_repair	4.31021075
4	MP0008057_abnormal_DNA_replication	4.13563138
5	MP0003786_premature_aging	4.12028657
6	MP0010094_abnormal_chromosome_stability	3.45946023
7	MP0001986_abnormal_taste_sensitivity	2.87350608
8	MP0003195_calcinosis	2.68860966
9	MP0003111_abnormal_nucleus_morphology	2.60044202
10	MP0000678_abnormal_parathyroid_gland	2.55792856
11	MP0005083_abnormal_biliary_tract	2.51275329
12	MP0004019_abnormal_vitamin_homeostasis	2.48286154
13	MP0003646_muscle_fatigue	2.35494718
14	MP0002132_abnormal_respiratory_system	2.30840527
15	MP0002638_abnormal_pupillary_reflex	2.25264273
16	MP0005408_hypopigmentation	2.03636405
17	MP0005397_hematopoietic_system_phenotyp	1.98837739
18	MP0001545_abnormal_hematopoietic_system	1.98837739
19	MP0003718_maternal_effect	1.96927326
20	MP0004957_abnormal_blastocyst_morpholog	1.92728287
21	MP0008932_abnormal_embryonic_tissue	1.77235590
22	MP0001929_abnormal_gametogenesis	1.75993300
23	MP0001501_abnormal_sleep_pattern	1.74301765
24	MP0006036_abnormal_mitochondrial_physio	1.72560725
25	MP0002210_abnormal_sex_determination	1.67611688
26	MP0003693_abnormal_embryo_hatching	1.62591684
27	MP0006292_abnormal_olfactory_placode	1.62488158
28	MP0009697_abnormal_copulation	1.56559015
29	MP0002938_white_spotting	1.48253417
30	MP0000372_irregular_coat_pigmentation	1.47657456
31	MP0002095_abnormal_skin_pigmentation	1.46067216
32	MP0003077_abnormal_cell_cycle	1.46054175
33	MP0003656_abnormal_erythrocyte_physiolo	1.42368571
34	MP0003698_abnormal_male_reproductive	1.40322003
35	MP0005410_abnormal_fertilization	1.38292487
36	MP0003950_abnormal_plasma_membrane	1.37410481
37	MP0000358_abnormal_cell_content/	1.35436286
38	MP0005646_abnormal_pituitary_gland	1.32850362
39	MP0008775_abnormal_heart_ventricle	1.25861862
40	MP0001764_abnormal_homeostasis	1.23896684
41	MP0001145_abnormal_male_reproductive	1.23325998
42	MP0001502_abnormal_circadian_rhythm	1.19448632
43	MP0000653_abnormal_sex_gland	1.17236295
44	MP0008007_abnormal_cellular_replicative	1.16317219
45	MP0001873_stomach_inflammation	1.10646035
46	MP0003984_embryonic_growth_retardation	1.09560179
47	MP0001697_abnormal_embryo_size	1.07426591
48	MP0000313_abnormal_cell_death	1.06369172
49	MP0002088_abnormal_embryonic_growth/wei	1.06048559
50	MP0010307_abnormal_tumor_latency	1.03548712
51	MP0005636_abnormal_mineral_homeostasis	1.01566684
52	MP0005380_embryogenesis_phenotype	1.00737653
53	MP0001672_abnormal_embryogenesis/_devel	1.00737653
54	MP0005332_abnormal_amino_acid	1.00300944
55	MP0008872_abnormal_physiological_respon	0.99471659
56	MP0009046_muscle_twitch	0.96563083
57	MP0002139_abnormal_hepatobiliary_system	0.95691969
58	MP0006276_abnormal_autonomic_nervous	0.95079317
59	MP0008875_abnormal_xenobiotic_pharmacok	0.94065293
60	MP0006035_abnormal_mitochondrial_morpho	0.93972637
61	MP0004885_abnormal_endolymph	0.93693038
62	MP0005167_abnormal_blood-brain_barrier	0.92113963
63	MP0001853_heart_inflammation	0.87729334
64	MP0003959_abnormal_lean_body	0.86087415
65	MP0003385_abnormal_body_wall	0.84445819
66	MP0005174_abnormal_tail_pigmentation	0.83867849
67	MP0004272_abnormal_basement_membrane	0.83501003
68	MP0004142_abnormal_muscle_tone	0.82644930
69	MP0000681_abnormal_thyroid_gland	0.82347813
70	MP0004043_abnormal_pH_regulation	0.80332958
71	MP0004134_abnormal_chest_morphology	0.78938243
72	MP0004233_abnormal_muscle_weight	0.78075055
73	MP0002234_abnormal_pharynx_morphology	0.77330379
74	MP0005253_abnormal_eye_physiology	0.76584785
75	MP0005451_abnormal_body_composition	0.76026692
76	MP0005551_abnormal_eye_electrophysiolog	0.75801622
77	MP0009765_abnormal_xenobiotic_induced	0.74339566
78	MP0002396_abnormal_hematopoietic_system	0.73164509
79	MP0001119_abnormal_female_reproductive	0.71221554
80	MP0005266_abnormal_metabolism	0.70238597
81	MP0002080_prenatal_lethality	0.68735429
82	MP0001661_extended_life_span	0.65409159
83	MP0005376_homeostasis/metabolism_phenot	0.65204044
84	MP0002161_abnormal_fertility/fecundity	0.64714469
85	MP0003937_abnormal_limbs/digits/tail_de	0.64623412
86	MP0002084_abnormal_developmental_patter	0.63853668
87	MP0002086_abnormal_extraembryonic_tissu	0.63179123
88	MP0002009_preneoplasia	0.62835831
89	MP0002019_abnormal_tumor_incidence	0.61886238
90	MP0003699_abnormal_female_reproductive	0.61794435
91	MP0009278_abnormal_bone_marrow	0.61486592
92	MP0000350_abnormal_cell_proliferation	0.59808814
93	MP0003806_abnormal_nucleotide_metabolis	0.58532686
94	MP0000427_abnormal_hair_cycle	0.58041641
95	MP0000538_abnormal_urinary_bladder	0.57451913
96	MP0002272_abnormal_nervous_system	0.57374065
97	MP0002735_abnormal_chemical_nociception	0.57126394
98	MP0006072_abnormal_retinal_apoptosis	0.55916536
99	MP0000015_abnormal_ear_pigmentation	0.53785787
100	MP0000609_abnormal_liver_physiology	0.53623129

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromsome breakage (HP:0040012)	5.67520840
2	Chromosomal breakage induced by crosslinking agents (HP:0003221)	5.60571652
3	Hyperthyroidism (HP:0000836)	4.73093597
4	Abnormality of homocysteine metabolism (HP:0010919)	4.36624252
5	Homocystinuria (HP:0002156)	4.36624252
6	Abnormal gallbladder physiology (HP:0012438)	4.08270957
7	Cholecystitis (HP:0001082)	4.08270957
8	Ileus (HP:0002595)	3.85860163
9	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.78791108
10	Truncus arteriosus (HP:0001660)	3.76545375
11	Abnormality of DNA repair (HP:0003254)	3.72180597
12	Severe visual impairment (HP:0001141)	3.53066573
13	Abnormality of chromosome stability (HP:0003220)	3.49882527
14	Abnormality of the preputium (HP:0100587)	3.47851967
15	Short middle phalanx of the 5th finger (HP:0004220)	3.36917964
16	Duodenal stenosis (HP:0100867)	3.31689887
17	Small intestinal stenosis (HP:0012848)	3.31689887
18	Duplicated collecting system (HP:0000081)	3.27372716
19	Acute necrotizing encephalopathy (HP:0006965)	3.23646779
20	Abnormal mitochondria in muscle tissue (HP:0008316)	3.18003260
21	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.14077035
22	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.13244658
23	Hypertensive crisis (HP:0100735)	3.08307732
24	Meckel diverticulum (HP:0002245)	3.06342629
25	Acute encephalopathy (HP:0006846)	3.01026098
26	Reticulocytosis (HP:0001923)	2.97259628
27	Abnormality of the renal collecting system (HP:0004742)	2.95753704
28	Abnormality of reticulocytes (HP:0004312)	2.87515537
29	Progressive macrocephaly (HP:0004481)	2.87162059
30	Abnormality of the ileum (HP:0001549)	2.86151821
31	Birth length less than 3rd percentile (HP:0003561)	2.83492469
32	Abnormal hemoglobin (HP:0011902)	2.78639657
33	Polycythemia (HP:0001901)	2.76840947
34	Reticulocytopenia (HP:0001896)	2.66944677
35	Acanthocytosis (HP:0001927)	2.56813115
36	Increased serum pyruvate (HP:0003542)	2.55280962
37	Sloping forehead (HP:0000340)	2.52048463
38	Abnormality of the duodenum (HP:0002246)	2.51161825
39	Hypoparathyroidism (HP:0000829)	2.49476984
40	Neoplasm of the small intestine (HP:0100833)	2.48930667
41	Myelodysplasia (HP:0002863)	2.46716561
42	Hypoplastic iliac wings (HP:0002866)	2.46279277
43	Secondary amenorrhea (HP:0000869)	2.44227248
44	Abnormality of the carotid arteries (HP:0005344)	2.43865683
45	Abnormality of glycolysis (HP:0004366)	2.42802513
46	Type II lissencephaly (HP:0007260)	2.41937672
47	Increased CSF lactate (HP:0002490)	2.40557772
48	Attenuation of retinal blood vessels (HP:0007843)	2.39643056
49	Protruding tongue (HP:0010808)	2.34652381
50	Poikiloderma (HP:0001029)	2.34562281
51	Clubbing of toes (HP:0100760)	2.34187310
52	Poikilocytosis (HP:0004447)	2.33490681
53	Acute myeloid leukemia (HP:0004808)	2.31969505
54	Seborrheic dermatitis (HP:0001051)	2.31066577
55	Erythroderma (HP:0001019)	2.25164771
56	Abnormality of the tricuspid valve (HP:0001702)	2.21598789
57	Squamous cell carcinoma (HP:0002860)	2.14834085
58	Aplasia/Hypoplasia of the thymus (HP:0010515)	2.14516614
59	Atelectasis (HP:0100750)	2.13512019
60	Pallor (HP:0000980)	2.11408872
61	Abnormally folded helix (HP:0008544)	2.08415822
62	Congenital ichthyosiform erythroderma (HP:0007431)	2.08201365
63	Abnormality of cochlea (HP:0000375)	2.06899505
64	Bowel incontinence (HP:0002607)	2.03846825
65	Increased serum lactate (HP:0002151)	2.02831071
66	Premature ovarian failure (HP:0008209)	2.02766889
67	Patchy hypopigmentation of hair (HP:0011365)	2.01740393
68	Cholelithiasis (HP:0001081)	2.00592811
69	Central scotoma (HP:0000603)	2.00228405
70	White forelock (HP:0002211)	1.99600205
71	Progressive muscle weakness (HP:0003323)	1.99174736
72	Overfolded helix (HP:0000396)	1.99115926
73	Abnormal hair laboratory examination (HP:0003328)	1.98957541
74	Absent thumb (HP:0009777)	1.98056441
75	Short 5th finger (HP:0009237)	1.96975429
76	Hypergonadotropic hypogonadism (HP:0000815)	1.93837455
77	Triphalangeal thumb (HP:0001199)	1.93730657
78	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.93346836
79	Abnormality of alanine metabolism (HP:0010916)	1.93346836
80	Hyperalaninemia (HP:0003348)	1.93346836
81	3-Methylglutaconic aciduria (HP:0003535)	1.93149706
82	Abnormality of pyrimidine metabolism (HP:0004353)	1.93035748
83	Pheochromocytoma (HP:0002666)	1.92082162
84	Abnormal rod and cone electroretinograms (HP:0008323)	1.91797572
85	Hypoplasia of the pons (HP:0012110)	1.90342980
86	Microvesicular hepatic steatosis (HP:0001414)	1.90194287
87	Pili torti (HP:0003777)	1.89997892
88	Optic disc pallor (HP:0000543)	1.89305696
89	Abnormal large intestine physiology (HP:0012700)	1.88421672
90	Neoplasm of the oral cavity (HP:0100649)	1.87852968
91	Sandal gap (HP:0001852)	1.86961354
92	Mitochondrial inheritance (HP:0001427)	1.86863659
93	Cutaneous melanoma (HP:0012056)	1.86169283
94	Arteriovenous malformation (HP:0100026)	1.85126655
95	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.83251165
96	Neuroendocrine neoplasm (HP:0100634)	1.81296966
97	Cerebellar dysplasia (HP:0007033)	1.80994555
98	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.79948679
99	Ragged-red muscle fibers (HP:0003200)	1.79796848
100	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	1.78198659

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	8.00674502
2	FRK	5.21282512
3	RIPK4	3.47104603
4	BRSK2	3.28032695
5	EIF2AK1	3.11234308
6	PLK4	3.04623730
7	CDC7	2.95645290
8	TAOK3	2.74780399
9	CLK1	2.68871479
10	TTK	2.54011298
11	CHEK2	1.66232116
12	MKNK1	1.58767117
13	CCNB1	1.55071100
14	NME1	1.49565198
15	WEE1	1.45289913
16	PIK3CG	1.41095338
17	RAF1	1.40859431
18	NTRK3	1.40034949
19	BMPR2	1.39132096
20	KSR2	1.37550388
21	NEK1	1.36301117
22	TEC	1.25841013
23	NEK2	1.24476731
24	NEK6	1.21204533
25	ATR	1.09632020
26	BRSK1	1.06216238
27	PLK2	1.05264050
28	MKNK2	0.97778483
29	CAMK1D	0.97663345
30	NUAK1	0.95574356
31	ATM	0.92421555
32	MAPK12	0.88280040
33	MAPK7	0.85815203
34	STK38L	0.85181394
35	BUB1	0.84755380
36	RPS6KB2	0.81086244
37	MAP2K1	0.80235682
38	DAPK2	0.79528113
39	MARK3	0.79237489
40	MAP3K4	0.78888798
41	SRPK1	0.76359778
42	MAP3K2	0.75202386
43	MAPK13	0.70919985
44	PLK1	0.70783063
45	ZAK	0.68515069
46	KSR1	0.68463627
47	PLK3	0.67254166
48	NME2	0.66665538
49	RPS6KA5	0.66397452
50	MAPKAPK5	0.64390009
51	CHEK1	0.61202911
52	CDK1	0.59838964
53	BMX	0.59735723
54	STK3	0.54263599
55	WNK4	0.53326644
56	STK38	0.52774307
57	BRD4	0.52137518
58	SGK1	0.52129873
59	PRKDC	0.50800265
60	PRKAA1	0.50524297
61	TRIM28	0.47965984
62	ALK	0.46793447
63	CDK2	0.45575908
64	IKBKB	0.45438446
65	STK4	0.44917456
66	JAK2	0.43938865
67	MAP3K13	0.43707022
68	CAMK1G	0.42960802
69	PINK1	0.41890175
70	CSNK1E	0.41769157
71	BMPR1B	0.41676362
72	PRKAA2	0.41653273
73	MAPK11	0.41622629
74	GSK3B	0.41530689
75	PAK3	0.39819771
76	TNK2	0.39148288
77	MAP3K8	0.38747282
78	ADRBK2	0.38658615
79	CSNK2A1	0.37719970
80	MAPK3	0.37451486
81	MAP2K2	0.36496680
82	CSNK2A2	0.36387597
83	PKN1	0.35537125
84	AURKB	0.33529259
85	EPHA4	0.32564969
86	MAPK14	0.32532697
87	CAMK1	0.31024142
88	MAP3K7	0.30320543
89	PAK1	0.30105165
90	MAPK1	0.30036982
91	MAPK10	0.27308198
92	PDK1	0.25266679
93	PBK	0.24191019
94	MAP2K6	0.23283996
95	BTK	0.22611996
96	RPS6KA3	0.21777064
97	PIM1	0.21153288
98	DYRK1A	0.21089228
99	PRKCA	0.21078291
100	MAP3K9	0.20789824

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	4.43975161
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.04564179
3	Olfactory transduction_Homo sapiens_hsa04740	4.02079681
4	One carbon pool by folate_Homo sapiens_hsa00670	3.85885408
5	Fanconi anemia pathway_Homo sapiens_hsa03460	3.52524445
6	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.41125846
7	Butanoate metabolism_Homo sapiens_hsa00650	3.30475417
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.82127885
9	Steroid biosynthesis_Homo sapiens_hsa00100	2.49736278
10	DNA replication_Homo sapiens_hsa03030	2.30928823
11	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.14980115
12	Mismatch repair_Homo sapiens_hsa03430	1.92804452
13	Non-homologous end-joining_Homo sapiens_hsa03450	1.91226279
14	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.89933545
15	RNA transport_Homo sapiens_hsa03013	1.69086853
16	Base excision repair_Homo sapiens_hsa03410	1.68219258
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.67123189
18	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.66650170
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.62701961
20	Pyruvate metabolism_Homo sapiens_hsa00620	1.57084603
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.56820406
22	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.50275967
23	Oxidative phosphorylation_Homo sapiens_hsa00190	1.50196650
24	Basal transcription factors_Homo sapiens_hsa03022	1.43938769
25	Ribosome_Homo sapiens_hsa03010	1.40488959
26	RNA polymerase_Homo sapiens_hsa03020	1.39490563
27	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.31062086
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.29794511
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.27133593
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.26832930
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.20979667
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.13057910
33	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.12590674
34	Fatty acid metabolism_Homo sapiens_hsa01212	1.09583078
35	Parkinsons disease_Homo sapiens_hsa05012	1.06166921
36	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.04594067
37	Spliceosome_Homo sapiens_hsa03040	1.03629237
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.01284808
39	Lysine degradation_Homo sapiens_hsa00310	0.98986988
40	Cell cycle_Homo sapiens_hsa04110	0.98879785
41	Propanoate metabolism_Homo sapiens_hsa00640	0.97459127
42	Huntingtons disease_Homo sapiens_hsa05016	0.94337772
43	Pyrimidine metabolism_Homo sapiens_hsa00240	0.91319164
44	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.90925882
45	Purine metabolism_Homo sapiens_hsa00230	0.90083448
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.87652871
47	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.87375451
48	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.86678983
49	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.85555137
50	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.85535753
51	Carbon metabolism_Homo sapiens_hsa01200	0.78656625
52	ABC transporters_Homo sapiens_hsa02010	0.77616066
53	RNA degradation_Homo sapiens_hsa03018	0.74499796
54	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.73135078
55	Metabolic pathways_Homo sapiens_hsa01100	0.67990782
56	Ether lipid metabolism_Homo sapiens_hsa00565	0.67102966
57	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.56730707
58	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.56206797
59	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.56060824
60	Retinol metabolism_Homo sapiens_hsa00830	0.55603347
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54626829
62	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.52957967
63	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52576887
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.51212211
65	Alzheimers disease_Homo sapiens_hsa05010	0.49805487
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.49149986
67	Collecting duct acid secretion_Homo sapiens_hsa04966	0.48983768
68	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.47812682
69	Protein export_Homo sapiens_hsa03060	0.47557458
70	mRNA surveillance pathway_Homo sapiens_hsa03015	0.45957574
71	Mineral absorption_Homo sapiens_hsa04978	0.44682155
72	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.42630358
73	Peroxisome_Homo sapiens_hsa04146	0.42466083
74	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.41797817
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.40993869
76	Arginine and proline metabolism_Homo sapiens_hsa00330	0.40310681
77	Oocyte meiosis_Homo sapiens_hsa04114	0.37989620
78	Nicotine addiction_Homo sapiens_hsa05033	0.37929344
79	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.37667824
80	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.36738505
81	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.36118100
82	Fatty acid elongation_Homo sapiens_hsa00062	0.34662362
83	Glutathione metabolism_Homo sapiens_hsa00480	0.33265900
84	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.33215990
85	Taste transduction_Homo sapiens_hsa04742	0.32217472
86	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.30042654
87	Fatty acid degradation_Homo sapiens_hsa00071	0.27798144
88	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.27538567
89	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.27183366
90	p53 signaling pathway_Homo sapiens_hsa04115	0.26245028
91	Prolactin signaling pathway_Homo sapiens_hsa04917	0.26064052
92	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.25544699
93	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.24500785
94	Cardiac muscle contraction_Homo sapiens_hsa04260	0.22276883
95	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.22273903
96	Tyrosine metabolism_Homo sapiens_hsa00350	0.22031743
97	Proteasome_Homo sapiens_hsa03050	0.21740872
98	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.21250199
99	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.17460980
100	Arginine biosynthesis_Homo sapiens_hsa00220	0.17223483

OR4G3P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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