ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of phosphoprotein phosphatase activity (GO:0043666)	6.92014545
2	acrosome reaction (GO:0007340)	6.15805060
3	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	6.12004476
4	sperm motility (GO:0030317)	5.93078283
5	axonemal dynein complex assembly (GO:0070286)	5.64841748
6	multicellular organism reproduction (GO:0032504)	5.60910709
7	positive regulation of catecholamine secretion (GO:0033605)	5.60307959
8	spermatid development (GO:0007286)	5.52467449
9	male meiosis (GO:0007140)	5.40589273
10	cilium or flagellum-dependent cell motility (GO:0001539)	5.16361641
11	motile cilium assembly (GO:0044458)	5.15113264
12	cGMP-mediated signaling (GO:0019934)	4.80972879
13	neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)	4.53982026
14	relaxation of smooth muscle (GO:0044557)	4.44628172
15	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	4.41965752
16	potassium ion export (GO:0071435)	4.40300947
17	carnitine shuttle (GO:0006853)	4.15564402
18	fusion of sperm to egg plasma membrane (GO:0007342)	4.12780226
19	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	4.09405300
20	response to epinephrine (GO:0071871)	4.07702722
21	dendritic spine morphogenesis (GO:0060997)	4.02589022
22	ventricular cardiac muscle cell action potential (GO:0086005)	4.01570885
23	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	3.97178470
24	reproduction (GO:0000003)	3.91918795
25	regulation of oxidative stress-induced neuron death (GO:1903203)	3.82825535
26	membrane repolarization during action potential (GO:0086011)	3.81341735
27	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	3.79506898
28	righting reflex (GO:0060013)	3.77970307
29	fatty acid transmembrane transport (GO:1902001)	3.77352172
30	organic cation transport (GO:0015695)	3.76050503
31	tongue development (GO:0043586)	3.75372395
32	binding of sperm to zona pellucida (GO:0007339)	3.75241870
33	sperm-egg recognition (GO:0035036)	3.73544458
34	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	3.69570999
35	epithelial cilium movement (GO:0003351)	3.64695032
36	single fertilization (GO:0007338)	3.63138656
37	cell communication by electrical coupling (GO:0010644)	3.57947771
38	potassium ion import (GO:0010107)	3.47012978
39	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	3.44425377
40	cardiac muscle cell action potential (GO:0086001)	3.40713484
41	sarcomere organization (GO:0045214)	3.40365059
42	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.40342749
43	cellular response to epinephrine stimulus (GO:0071872)	3.36522379
44	prostate gland growth (GO:0060736)	3.34718995
45	cell-cell recognition (GO:0009988)	3.32290243
46	coenzyme catabolic process (GO:0009109)	3.31470132
47	plasma membrane fusion (GO:0045026)	3.27519333
48	protein-DNA complex disassembly (GO:0032986)	3.26559659
49	nucleosome disassembly (GO:0006337)	3.26559659
50	regulation of membrane repolarization (GO:0060306)	3.23369191
51	activation of protein kinase B activity (GO:0032148)	3.23040456
52	relaxation of muscle (GO:0090075)	3.21344303
53	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.20588986
54	chemosensory behavior (GO:0007635)	3.17977047
55	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	3.16934219
56	negative regulation of actin filament bundle assembly (GO:0032232)	3.16922014
57	cardiac muscle cell action potential involved in contraction (GO:0086002)	3.16771636
58	bundle of His cell to Purkinje myocyte communication (GO:0086069)	3.14699930
59	phosphatidylethanolamine metabolic process (GO:0046337)	3.14399131
60	male sex determination (GO:0030238)	3.14253918
61	regulation of dopamine secretion (GO:0014059)	3.13925638
62	polyamine biosynthetic process (GO:0006596)	3.13465343
63	cardiac muscle hypertrophy (GO:0003300)	3.13213055
64	carnitine transmembrane transport (GO:1902603)	3.12113423
65	urinary tract smooth muscle contraction (GO:0014848)	3.09407127
66	germ cell development (GO:0007281)	3.09109250
67	amino-acid betaine transport (GO:0015838)	3.08545255
68	carnitine transport (GO:0015879)	3.08545255
69	calcium ion-dependent exocytosis (GO:0017156)	3.08305681
70	regulation of oxidative phosphorylation (GO:0002082)	3.07896066
71	cellular response to toxic substance (GO:0097237)	3.07584483
72	negative regulation of Rho protein signal transduction (GO:0035024)	3.07378825
73	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	3.05504059
74	cell communication involved in cardiac conduction (GO:0086065)	3.05097549
75	cilium movement (GO:0003341)	3.03266714
76	regulation of p38MAPK cascade (GO:1900744)	3.02522356
77	regulation of cellular respiration (GO:0043457)	3.01684956
78	membrane repolarization (GO:0086009)	2.99883490
79	aspartate family amino acid catabolic process (GO:0009068)	2.99176911
80	response to acidic pH (GO:0010447)	2.97500528
81	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.96694743
82	striated muscle hypertrophy (GO:0014897)	2.94843587
83	receptor catabolic process (GO:0032801)	2.94834306
84	regulation of cardiac muscle contraction (GO:0055117)	2.93118606
85	regulation of striated muscle contraction (GO:0006942)	2.87542818
86	embryonic heart tube development (GO:0035050)	2.86699164
87	Leydig cell differentiation (GO:0033327)	2.83383726
88	regulation of actin filament-based movement (GO:1903115)	2.80855512
89	retina vasculature morphogenesis in camera-type eye (GO:0061299)	2.80786130
90	membrane depolarization during action potential (GO:0086010)	2.80706042
91	dicarboxylic acid catabolic process (GO:0043649)	2.80468205
92	detection of calcium ion (GO:0005513)	2.79389415
93	indole-containing compound catabolic process (GO:0042436)	2.77454623
94	indolalkylamine catabolic process (GO:0046218)	2.77454623
95	tryptophan catabolic process (GO:0006569)	2.77454623
96	synapsis (GO:0007129)	2.77340638
97	regulation of synaptic transmission, dopaminergic (GO:0032225)	2.77187669
98	negative regulation of response to reactive oxygen species (GO:1901032)	2.75832000
99	dendritic spine organization (GO:0097061)	2.75510080
100	regulation of hydrogen peroxide-induced cell death (GO:1903205)	2.74928357

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.56863505
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.63343709
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.84550088
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.20333254
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.67114094
6	VDR_22108803_ChIP-Seq_LS180_Human	2.60839519
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.37135520
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.37038937
9	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.30229812
10	EP300_21415370_ChIP-Seq_HL-1_Mouse	2.07025300
11	FUS_26573619_Chip-Seq_HEK293_Human	2.00548575
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.93285505
13	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.88852408
14	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.87912095
15	AR_21572438_ChIP-Seq_LNCaP_Human	1.85843840
16	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.85632047
17	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.81560251
18	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.81156999
19	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.71983496
20	AHR_22903824_ChIP-Seq_MCF-7_Human	1.63796572
21	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.62533109
22	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.62533109
23	P300_19829295_ChIP-Seq_ESCs_Human	1.60606701
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.60269907
25	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.58739023
26	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.58711550
27	CBP_20019798_ChIP-Seq_JUKART_Human	1.58567036
28	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.58567036
29	SMAD4_21799915_ChIP-Seq_A2780_Human	1.54172931
30	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.53698821
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.52725709
32	BCAT_22108803_ChIP-Seq_LS180_Human	1.50013021
33	RXR_22108803_ChIP-Seq_LS180_Human	1.48916998
34	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.47686508
35	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.42541381
36	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.42218415
37	TP53_16413492_ChIP-PET_HCT116_Human	1.41769058
38	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.38902263
39	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.38435651
40	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.38363081
41	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.37385360
42	STAT3_23295773_ChIP-Seq_U87_Human	1.36915381
43	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.36845690
44	TP53_18474530_ChIP-ChIP_U2OS_Human	1.35541412
45	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.35113342
46	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.35113342
47	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.29504164
48	RUNX2_22187159_ChIP-Seq_PCA_Human	1.29146834
49	AR_25329375_ChIP-Seq_VCAP_Human	1.28712491
50	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.28657661
51	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.26002740
52	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.24491163
53	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.23303905
54	TBL1_22424771_ChIP-Seq_293T_Human	1.21568899
55	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.20263208
56	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19681453
57	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19681453
58	DROSHA_22980978_ChIP-Seq_HELA_Human	1.18210497
59	OCT4_20526341_ChIP-Seq_ESCs_Human	1.17928121
60	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.17847306
61	CJUN_26792858_Chip-Seq_BT549_Human	1.17198048
62	NANOG_20526341_ChIP-Seq_ESCs_Human	1.16769068
63	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16613290
64	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.16564767
65	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.15797340
66	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.13165944
67	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12375323
68	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.11689592
69	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.11685875
70	TCF4_23295773_ChIP-Seq_U87_Human	1.11499386
71	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10915770
72	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.10832981
73	TAF15_26573619_Chip-Seq_HEK293_Human	1.08940765
74	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.07319967
75	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.06262825
76	RAC3_21632823_ChIP-Seq_H3396_Human	1.04874821
77	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.04455701
78	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.03418030
79	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.03396583
80	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.02335412
81	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.02250034
82	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.01477187
83	ERA_21632823_ChIP-Seq_H3396_Human	1.01092146
84	ZNF274_21170338_ChIP-Seq_K562_Hela	0.96920146
85	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.96428043
86	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.95894103
87	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95781195
88	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.95756295
89	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.95736680
90	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.95665097
91	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.95509404
92	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.94745958
93	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.93938496
94	NFYB_21822215_ChIP-Seq_K562_Human	0.93690775
95	AR_19668381_ChIP-Seq_PC3_Human	0.92959315
96	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.92949590
97	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.90722503
98	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.90153831
99	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.87452869
100	HOXB7_26014856_ChIP-Seq_BT474_Human	0.86991345

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	6.22138640
2	MP0003315_abnormal_perineum_morphology	4.24215232
3	MP0008004_abnormal_stomach_pH	4.09879540
4	MP0000751_myopathy	3.31463066
5	MP0001986_abnormal_taste_sensitivity	2.83814094
6	MP0004084_abnormal_cardiac_muscle	2.82149802
7	MP0003646_muscle_fatigue	2.79067833
8	MP0005409_darkened_coat_color	2.73630979
9	MP0003136_yellow_coat_color	2.66839567
10	MP0002837_dystrophic_cardiac_calcinosis	2.65864209
11	MP0010368_abnormal_lymphatic_system	2.56338620
12	MP0004215_abnormal_myocardial_fiber	2.55831818
13	MP0002638_abnormal_pupillary_reflex	2.39635877
14	MP0004510_myositis	2.33007405
15	MP0003045_fibrosis	2.21797206
16	MP0001661_extended_life_span	2.14871812
17	MP0003698_abnormal_male_reproductive	2.14444601
18	MP0005360_urolithiasis	2.13933927
19	MP0002160_abnormal_reproductive_system	2.11570993
20	MP0005423_abnormal_somatic_nervous	2.08291183
21	MP0005187_abnormal_penis_morphology	2.03187777
22	MP0004036_abnormal_muscle_relaxation	1.95829581
23	MP0003137_abnormal_impulse_conducting	1.78277753
24	MP0001929_abnormal_gametogenesis	1.75717314
25	MP0001664_abnormal_digestion	1.75146783
26	MP0006138_congestive_heart_failure	1.72335604
27	MP0004085_abnormal_heartbeat	1.71744358
28	MP0001501_abnormal_sleep_pattern	1.66862372
29	MP0008995_early_reproductive_senescence	1.65304847
30	MP0005646_abnormal_pituitary_gland	1.64587592
31	MP0009046_muscle_twitch	1.61981775
32	MP0008775_abnormal_heart_ventricle	1.60946108
33	MP0006276_abnormal_autonomic_nervous	1.60644147
34	MP0005275_abnormal_skin_tensile	1.55489772
35	MP0005647_abnormal_sex_gland	1.47440687
36	MP0004484_altered_response_of	1.44064485
37	MP0000750_abnormal_muscle_regeneration	1.41235689
38	MP0000749_muscle_degeneration	1.40269676
39	MP0001486_abnormal_startle_reflex	1.39007172
40	MP0005620_abnormal_muscle_contractility	1.38701437
41	MP0001879_abnormal_lymphatic_vessel	1.36281810
42	MP0004145_abnormal_muscle_electrophysio	1.35039012
43	MP0004272_abnormal_basement_membrane	1.32330635
44	MP0005330_cardiomyopathy	1.28111765
45	MP0002127_abnormal_cardiovascular_syste	1.27747083
46	MP0001984_abnormal_olfaction	1.24660676
47	MP0002972_abnormal_cardiac_muscle	1.22994001
48	MP0002132_abnormal_respiratory_system	1.20299191
49	MP0001544_abnormal_cardiovascular_syste	1.20027023
50	MP0005385_cardiovascular_system_phenoty	1.20027023
51	MP0004087_abnormal_muscle_fiber	1.18249055
52	MP0000537_abnormal_urethra_morphology	1.16832455
53	MP0010386_abnormal_urinary_bladder	1.13950574
54	MP0003878_abnormal_ear_physiology	1.12894195
55	MP0005377_hearing/vestibular/ear_phenot	1.12894195
56	MP0002106_abnormal_muscle_physiology	1.11915302
57	MP0002272_abnormal_nervous_system	1.11014580
58	MP0001968_abnormal_touch/_nociception	1.10643342
59	MP0002108_abnormal_muscle_morphology	1.08343026
60	MP0004142_abnormal_muscle_tone	1.07272554
61	MP0005369_muscle_phenotype	1.04064586
62	MP0002269_muscular_atrophy	1.02249646
63	MP0003879_abnormal_hair_cell	1.00347875
64	MP0001485_abnormal_pinna_reflex	0.98737450
65	MP0002161_abnormal_fertility/fecundity	0.96552990
66	MP0005551_abnormal_eye_electrophysiolog	0.94688292
67	MP0004130_abnormal_muscle_cell	0.92491973
68	MP0001963_abnormal_hearing_physiology	0.92424967
69	MP0005670_abnormal_white_adipose	0.92244650
70	MP0000343_altered_response_to	0.91743439
71	MP0000230_abnormal_systemic_arterial	0.91643519
72	MP0003868_abnormal_feces_composition	0.88584511
73	MP0005595_abnormal_vascular_smooth	0.88490242
74	MP0006072_abnormal_retinal_apoptosis	0.88011521
75	MP0005389_reproductive_system_phenotype	0.86349160
76	MP0010630_abnormal_cardiac_muscle	0.84782785
77	MP0000026_abnormal_inner_ear	0.83840394
78	MP0002067_abnormal_sensory_capabilities	0.82903539
79	MP0006036_abnormal_mitochondrial_physio	0.81090554
80	MP0002210_abnormal_sex_determination	0.80423383
81	MP0002168_other_aberrant_phenotype	0.78067144
82	MP0000538_abnormal_urinary_bladder	0.77420015
83	MP0001145_abnormal_male_reproductive	0.77051631
84	MP0003880_abnormal_central_pattern	0.76862882
85	MP0009745_abnormal_behavioral_response	0.74815172
86	MP0000747_muscle_weakness	0.74566804
87	MP0000653_abnormal_sex_gland	0.73579787
88	MP0002735_abnormal_chemical_nociception	0.73123806
89	MP0005503_abnormal_tendon_morphology	0.72359333
90	MP0005165_increased_susceptibility_to	0.71763808
91	MP0003632_abnormal_nervous_system	0.71498774
92	MP0005253_abnormal_eye_physiology	0.71293322
93	MP0002064_seizures	0.69322506
94	MP0003283_abnormal_digestive_organ	0.69017042
95	MP0002998_abnormal_bone_remodeling	0.66906069
96	MP0003631_nervous_system_phenotype	0.65876970
97	MP0003828_pulmonary_edema	0.65403195
98	MP0005171_absent_coat_pigmentation	0.64999254
99	MP0009115_abnormal_fat_cell	0.64629010
100	MP0000462_abnormal_digestive_system	0.62991916

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Tongue fasciculations (HP:0001308)	7.01929671
2	Muscle fibrillation (HP:0010546)	6.34158079
3	Syncope (HP:0001279)	5.24180223
4	Slow saccadic eye movements (HP:0000514)	5.06916574
5	Atrial fibrillation (HP:0005110)	4.99855907
6	Ventricular fibrillation (HP:0001663)	4.84532123
7	Resting tremor (HP:0002322)	4.79604977
8	Primary atrial arrhythmia (HP:0001692)	4.40781341
9	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.36344944
10	Absent/shortened dynein arms (HP:0200106)	4.36344944
11	Sudden death (HP:0001699)	4.20467546
12	Supraventricular tachycardia (HP:0004755)	4.19349472
13	Abnormal respiratory epithelium morphology (HP:0012253)	4.17556157
14	Abnormal respiratory motile cilium morphology (HP:0005938)	4.17556157
15	Abnormality of the columella (HP:0009929)	4.14924371
16	Supraventricular arrhythmia (HP:0005115)	4.06281444
17	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.05196570
18	Sex reversal (HP:0012245)	3.86282093
19	Abnormal sex determination (HP:0012244)	3.86282093
20	Abnormal respiratory motile cilium physiology (HP:0012261)	3.78852241
21	Bundle branch block (HP:0011710)	3.73171531
22	Prolonged QT interval (HP:0001657)	3.73147667
23	Abnormal ciliary motility (HP:0012262)	3.72945490
24	Clumsiness (HP:0002312)	3.68419628
25	Muscle fiber splitting (HP:0003555)	3.54075101
26	Protruding tongue (HP:0010808)	3.52353106
27	Pigmentary retinal degeneration (HP:0001146)	3.49625684
28	Ventricular arrhythmia (HP:0004308)	3.45309142
29	Ventricular tachycardia (HP:0004756)	3.44544090
30	Hyporeflexia of lower limbs (HP:0002600)	3.39168452
31	Reduced antithrombin III activity (HP:0001976)	3.30357472
32	Abnormality of the intrinsic pathway (HP:0010989)	3.27150315
33	Hypoplasia of the uterus (HP:0000013)	3.23175486
34	Right ventricular cardiomyopathy (HP:0011663)	3.21040931
35	Congenital sensorineural hearing impairment (HP:0008527)	3.19730292
36	Impaired smooth pursuit (HP:0007772)	3.03738377
37	Postural instability (HP:0002172)	3.01970163
38	Abnormal EKG (HP:0003115)	2.89732515
39	Male pseudohermaphroditism (HP:0000037)	2.81491393
40	Gonadal dysgenesis (HP:0000133)	2.79010940
41	Chronic hepatic failure (HP:0100626)	2.73503882
42	Infertility (HP:0000789)	2.70035982
43	Rhinitis (HP:0012384)	2.61842239
44	Lipoatrophy (HP:0100578)	2.56134959
45	Absent speech (HP:0001344)	2.47786129
46	Abnormality of saccadic eye movements (HP:0000570)	2.45873491
47	Colitis (HP:0002583)	2.45576375
48	Absent eyebrow (HP:0002223)	2.35062476
49	Calf muscle hypertrophy (HP:0008981)	2.32085855
50	Hyperkalemia (HP:0002153)	2.26854770
51	Abnormality of the calf musculature (HP:0001430)	2.25636357
52	Palpitations (HP:0001962)	2.24231116
53	Heart block (HP:0012722)	2.23580910
54	Muscular dystrophy (HP:0003560)	2.19710007
55	Inability to walk (HP:0002540)	2.18944523
56	Atonic seizures (HP:0010819)	2.17513537
57	Cerebellar dysplasia (HP:0007033)	2.17109178
58	Self-mutilation (HP:0000742)	2.15955904
59	Lymphangioma (HP:0100764)	2.15105067
60	Germ cell neoplasia (HP:0100728)	2.13509607
61	Dilated cardiomyopathy (HP:0001644)	2.11489692
62	Abnormal tarsal ossification (HP:0008369)	2.11483355
63	Abnormal pancreas size (HP:0012094)	2.11407181
64	Abnormal drinking behavior (HP:0030082)	2.09026279
65	Polydipsia (HP:0001959)	2.09026279
66	Increased density of long bones (HP:0006392)	2.07506325
67	Limb ataxia (HP:0002070)	2.06945989
68	Fair hair (HP:0002286)	2.05945769
69	Aplasia/hypoplasia of the uterus (HP:0008684)	2.04401913
70	Muscle hypertrophy of the lower extremities (HP:0008968)	2.03972266
71	Atrioventricular block (HP:0001678)	2.02211832
72	Hemiplegia (HP:0002301)	1.99657994
73	Aplasia cutis congenita (HP:0001057)	1.98490316
74	Abnormal atrioventricular conduction (HP:0005150)	1.96834633
75	Abnormality of ocular smooth pursuit (HP:0000617)	1.95826252
76	Nonimmune hydrops fetalis (HP:0001790)	1.94961052
77	Anomalous pulmonary venous return (HP:0010772)	1.91458033
78	Adactyly (HP:0009776)	1.90134659
79	Preauricular pit (HP:0004467)	1.87031066
80	Periauricular skin pits (HP:0100277)	1.87031066
81	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.85236006
82	Chronic bronchitis (HP:0004469)	1.84286678
83	Absent eyelashes (HP:0000561)	1.82538313
84	Facial diplegia (HP:0001349)	1.81823572
85	EMG: myopathic abnormalities (HP:0003458)	1.78686500
86	Difficulty running (HP:0009046)	1.76533353
87	Persistence of primary teeth (HP:0006335)	1.76416461
88	Diaphragmatic weakness (HP:0009113)	1.76276220
89	True hermaphroditism (HP:0010459)	1.75588529
90	Pancreatic fibrosis (HP:0100732)	1.75430723
91	Retinal atrophy (HP:0001105)	1.74001616
92	Cystic liver disease (HP:0006706)	1.71591019
93	Nasal polyposis (HP:0100582)	1.71162497
94	Type II lissencephaly (HP:0007260)	1.70972018
95	Thoracic kyphosis (HP:0002942)	1.70858737
96	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.69268864
97	Joint hemorrhage (HP:0005261)	1.68920544
98	Chronic sinusitis (HP:0011109)	1.68698280
99	Recurrent corneal erosions (HP:0000495)	1.66213881
100	Thoracolumbar scoliosis (HP:0002944)	1.64845924

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	8.86831057
2	BLK	5.15126259
3	FRK	4.53379775
4	MARK3	4.21739989
5	MYLK	3.79655375
6	PDK2	2.60475732
7	TLK1	2.33610154
8	ZAK	2.20061096
9	INSRR	1.95023047
10	OBSCN	1.88287331
11	RPS6KA5	1.87155360
12	BMPR1B	1.86955081
13	LATS2	1.84921194
14	STK38	1.78598014
15	TIE1	1.75662715
16	CASK	1.68006395
17	STK38L	1.58449930
18	EIF2AK3	1.41543917
19	MUSK	1.30451628
20	TNIK	1.28816551
21	NEK2	1.12022704
22	SGK223	0.97403878
23	SGK494	0.97403878
24	MAPK15	0.95778637
25	ADRBK2	0.91334707
26	MAPK12	0.91246442
27	ICK	0.90057025
28	LATS1	0.89157826
29	PTK2B	0.87147260
30	STK4	0.86791450
31	PLK4	0.84469684
32	SGK2	0.79014986
33	PKN1	0.74962124
34	PAK3	0.73262206
35	MAP3K7	0.70212789
36	TGFBR1	0.69119081
37	DMPK	0.67098047
38	SYK	0.65842637
39	GRK1	0.65261775
40	PRKAA2	0.64615710
41	CDK3	0.63761330
42	MARK1	0.63411244
43	CDC42BPA	0.62834122
44	CAMK2D	0.57545741
45	PRKCQ	0.56267759
46	MELK	0.54077802
47	CAMK1	0.53190902
48	TTN	0.52612314
49	TAOK1	0.52214068
50	TRPM7	0.51496315
51	MATK	0.50544926
52	NEK6	0.49356169
53	DYRK3	0.47657387
54	MAPK7	0.47263770
55	PIK3CA	0.46885373
56	RPS6KA6	0.46787341
57	CAMK4	0.46028975
58	PRKG1	0.45432733
59	MAP4K2	0.45313189
60	PDPK1	0.45306517
61	EGFR	0.44802575
62	CCNB1	0.44491499
63	MAP2K7	0.42440305
64	PRPF4B	0.41887059
65	ROCK1	0.41827553
66	NEK9	0.41098703
67	CAMK2A	0.40777866
68	STK39	0.40777747
69	WNK1	0.40367152
70	PDK1	0.40280994
71	EPHA4	0.40104072
72	AKT2	0.38821492
73	PRKG2	0.38353599
74	FGR	0.37394685
75	PHKG2	0.36695688
76	PHKG1	0.36695688
77	CAMK2B	0.36067943
78	PRKAA1	0.35875145
79	PRKD1	0.34568892
80	NTRK1	0.33587447
81	LMTK2	0.32946097
82	ILK	0.32360241
83	MAP3K10	0.32204898
84	SGK3	0.31323844
85	NTRK2	0.28164791
86	PRKACA	0.27739167
87	MAPK4	0.27634552
88	RPS6KC1	0.26705087
89	RPS6KL1	0.26705087
90	FGFR2	0.25372964
91	RPS6KA3	0.24285273
92	BRD4	0.24268764
93	PRKCE	0.24188352
94	WNK4	0.22802246
95	FES	0.21936292
96	RPS6KA1	0.21229884
97	AKT1	0.21140509
98	MTOR	0.20569376
99	MST1R	0.17390553
100	PDGFRB	0.16952152

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	3.56550936
2	Gap junction_Homo sapiens_hsa04540	3.38025596
3	Nitrogen metabolism_Homo sapiens_hsa00910	3.04219721
4	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	2.93939462
5	Dilated cardiomyopathy_Homo sapiens_hsa05414	2.88972442
6	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	2.39781734
7	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.37182816
8	Circadian rhythm_Homo sapiens_hsa04710	2.05001281
9	Cardiac muscle contraction_Homo sapiens_hsa04260	1.94618166
10	* Olfactory transduction_Homo sapiens_hsa04740	1.89307354
11	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.78935921
12	Apoptosis_Homo sapiens_hsa04210	1.71633771
13	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.70998511
14	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.68236635
15	Taste transduction_Homo sapiens_hsa04742	1.67165919
16	Renin secretion_Homo sapiens_hsa04924	1.64671938
17	Butanoate metabolism_Homo sapiens_hsa00650	1.62125855
18	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.61839857
19	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.57281192
20	Phagosome_Homo sapiens_hsa04145	1.51556615
21	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.50119403
22	Circadian entrainment_Homo sapiens_hsa04713	1.47957468
23	Alcoholism_Homo sapiens_hsa05034	1.42098632
24	Arginine biosynthesis_Homo sapiens_hsa00220	1.42064499
25	Propanoate metabolism_Homo sapiens_hsa00640	1.40815064
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.39748540
27	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.38750889
28	PPAR signaling pathway_Homo sapiens_hsa03320	1.37477483
29	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.36022430
30	Calcium signaling pathway_Homo sapiens_hsa04020	1.34836400
31	Gastric acid secretion_Homo sapiens_hsa04971	1.31310710
32	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.29779632
33	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.28063227
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.24943521
35	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.20851183
36	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.17620378
37	Insulin secretion_Homo sapiens_hsa04911	1.15504439
38	ABC transporters_Homo sapiens_hsa02010	1.14462188
39	ECM-receptor interaction_Homo sapiens_hsa04512	1.13208440
40	Glucagon signaling pathway_Homo sapiens_hsa04922	1.13113497
41	Linoleic acid metabolism_Homo sapiens_hsa00591	1.11768380
42	Salivary secretion_Homo sapiens_hsa04970	1.10521352
43	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.09815862
44	cAMP signaling pathway_Homo sapiens_hsa04024	1.09795581
45	Glutamatergic synapse_Homo sapiens_hsa04724	1.06388425
46	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.05038513
47	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.02992386
48	Fatty acid degradation_Homo sapiens_hsa00071	1.02752020
49	Nicotine addiction_Homo sapiens_hsa05033	0.96933774
50	Fatty acid metabolism_Homo sapiens_hsa01212	0.94141333
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92343801
52	Phenylalanine metabolism_Homo sapiens_hsa00360	0.91505350
53	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.89639833
54	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.86470095
55	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.84729144
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.84718629
57	Pancreatic secretion_Homo sapiens_hsa04972	0.83729157
58	Retinol metabolism_Homo sapiens_hsa00830	0.79846257
59	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.78720900
60	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.78258339
61	Morphine addiction_Homo sapiens_hsa05032	0.75619458
62	GABAergic synapse_Homo sapiens_hsa04727	0.75371831
63	Bile secretion_Homo sapiens_hsa04976	0.68518742
64	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.65991760
65	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.65214418
66	Cocaine addiction_Homo sapiens_hsa05030	0.64059996
67	Mineral absorption_Homo sapiens_hsa04978	0.62881368
68	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.61206702
69	Sphingolipid metabolism_Homo sapiens_hsa00600	0.61092212
70	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.60583812
71	Amphetamine addiction_Homo sapiens_hsa05031	0.59287049
72	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.58454870
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56237932
74	Insulin resistance_Homo sapiens_hsa04931	0.56144059
75	Glutathione metabolism_Homo sapiens_hsa00480	0.55734958
76	Cholinergic synapse_Homo sapiens_hsa04725	0.55176186
77	MAPK signaling pathway_Homo sapiens_hsa04010	0.54303780
78	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.52677282
79	Arginine and proline metabolism_Homo sapiens_hsa00330	0.51895915
80	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.51508291
81	Tyrosine metabolism_Homo sapiens_hsa00350	0.48100827
82	FoxO signaling pathway_Homo sapiens_hsa04068	0.47926647
83	Pyruvate metabolism_Homo sapiens_hsa00620	0.46896080
84	Protein digestion and absorption_Homo sapiens_hsa04974	0.45900324
85	Histidine metabolism_Homo sapiens_hsa00340	0.44377714
86	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.42758522
87	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.42709134
88	Platelet activation_Homo sapiens_hsa04611	0.42511804
89	Phototransduction_Homo sapiens_hsa04744	0.41662112
90	Complement and coagulation cascades_Homo sapiens_hsa04610	0.41156961
91	Purine metabolism_Homo sapiens_hsa00230	0.40442111
92	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.39562384
93	Glycerolipid metabolism_Homo sapiens_hsa00561	0.38582417
94	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.38067540
95	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.37732317
96	Focal adhesion_Homo sapiens_hsa04510	0.35904826
97	AMPK signaling pathway_Homo sapiens_hsa04152	0.34468660
98	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.30897106
99	Estrogen signaling pathway_Homo sapiens_hsa04915	0.29781607
100	Peroxisome_Homo sapiens_hsa04146	0.29096768

OR4N2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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