OR51B4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)8.19150619
2nuclear pore organization (GO:0006999)7.17357242
3pore complex assembly (GO:0046931)6.13142054
4regulation of translational fidelity (GO:0006450)5.80966599
5DNA replication checkpoint (GO:0000076)5.21837111
6DNA unwinding involved in DNA replication (GO:0006268)5.17656036
7protoporphyrinogen IX metabolic process (GO:0046501)4.94223368
8DNA topological change (GO:0006265)4.92325121
9mitotic sister chromatid segregation (GO:0000070)4.84011251
10mitotic nuclear envelope disassembly (GO:0007077)4.75604738
11sister chromatid segregation (GO:0000819)4.73201962
12formation of translation preinitiation complex (GO:0001731)4.69473450
13regulation of RNA export from nucleus (GO:0046831)4.61883885
14diterpenoid biosynthetic process (GO:0016102)4.42780578
15nuclear envelope disassembly (GO:0051081)4.42570160
16membrane disassembly (GO:0030397)4.42570160
17DNA replication initiation (GO:0006270)4.36497486
18folic acid-containing compound biosynthetic process (GO:0009396)4.35604323
19protoporphyrinogen IX biosynthetic process (GO:0006782)4.29483190
20regulation of histone H3-K4 methylation (GO:0051569)4.21944109
21mitotic chromosome condensation (GO:0007076)4.20029900
22tRNA aminoacylation for protein translation (GO:0006418)4.15271317
23regulation of histone H3-K27 methylation (GO:0061085)4.07125696
24tRNA aminoacylation (GO:0043039)4.05758401
25amino acid activation (GO:0043038)4.05758401
26DNA strand elongation involved in DNA replication (GO:0006271)4.00003370
27purine nucleobase biosynthetic process (GO:0009113)3.99513401
28regulation of mitotic spindle organization (GO:0060236)3.96819698
29meiotic chromosome segregation (GO:0045132)3.92821706
30regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.89740548
31DNA strand elongation (GO:0022616)3.89473520
32synapsis (GO:0007129)3.75921534
33terpenoid biosynthetic process (GO:0016114)3.75387974
34gas transport (GO:0015669)3.72883021
35regulation of nucleobase-containing compound transport (GO:0032239)3.72772106
36IMP biosynthetic process (GO:0006188)3.68068455
37telomere maintenance via semi-conservative replication (GO:0032201)3.67650848
38oxidative phosphorylation (GO:0006119)3.67061412
39vitamin A metabolic process (GO:0006776)3.63761208
40regulation of translational elongation (GO:0006448)3.63730873
41regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.59176554
42protein localization to chromosome, centromeric region (GO:0071459)3.57059674
43nucleobase biosynthetic process (GO:0046112)3.54620350
44protein localization to kinetochore (GO:0034501)3.50737527
45microtubule depolymerization (GO:0007019)3.48354102
46proline biosynthetic process (GO:0006561)3.46092487
47tetrahydrofolate metabolic process (GO:0046653)3.44602838
48resolution of meiotic recombination intermediates (GO:0000712)3.44384556
49regulation of centriole replication (GO:0046599)3.43444583
50Golgi transport vesicle coating (GO:0048200)3.41800232
51COPI coating of Golgi vesicle (GO:0048205)3.41800232
52mitotic recombination (GO:0006312)3.40918711
53intra-S DNA damage checkpoint (GO:0031573)3.39486952
54chromosome segregation (GO:0007059)3.38977711
55homocysteine metabolic process (GO:0050667)3.36131206
56erythrocyte maturation (GO:0043249)3.34552699
57protein export from nucleus (GO:0006611)3.34102835
58mitotic metaphase plate congression (GO:0007080)3.33618876
59ribosomal large subunit biogenesis (GO:0042273)3.31505566
60telomere maintenance via recombination (GO:0000722)3.30587603
61ribosome assembly (GO:0042255)3.30401760
62peptidyl-threonine dephosphorylation (GO:0035970)3.26275446
63IMP metabolic process (GO:0046040)3.22647988
64nuclear envelope organization (GO:0006998)3.19510278
65regulation of centrosome cycle (GO:0046605)3.16768161
66DNA conformation change (GO:0071103)3.12799649
67* detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.12406395
68centriole assembly (GO:0098534)3.12035439
69chromosome condensation (GO:0030261)3.11646129
70nucleobase-containing small molecule interconversion (GO:0015949)3.11476126
71oxygen transport (GO:0015671)3.11287806
72regulation of histone methylation (GO:0031060)3.10145016
73ribosome biogenesis (GO:0042254)3.08934602
74positive regulation of histone H3-K4 methylation (GO:0051571)3.08596308
75pteridine-containing compound biosynthetic process (GO:0042559)3.08224750
76DNA duplex unwinding (GO:0032508)3.04713413
77regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.04208139
78negative regulation of potassium ion transmembrane transport (GO:1901380)3.04104214
79* sensory perception of smell (GO:0007608)3.03212129
80regulation of spindle organization (GO:0090224)3.02630536
81mitotic G2/M transition checkpoint (GO:0044818)3.00823626
82DNA geometric change (GO:0032392)3.00544001
83mitotic sister chromatid cohesion (GO:0007064)2.99502118
84mitotic spindle checkpoint (GO:0071174)2.96607442
85regulation of chromosome segregation (GO:0051983)2.94986242
86definitive hemopoiesis (GO:0060216)2.94284907
87negative regulation of histone methylation (GO:0031061)2.93654163
88DNA packaging (GO:0006323)2.93222097
89response to vitamin A (GO:0033189)2.93190933
90DNA synthesis involved in DNA repair (GO:0000731)2.92291483
91negative regulation of chromosome segregation (GO:0051985)2.85642513
92mitotic spindle assembly checkpoint (GO:0007094)2.85370601
93ribonucleoprotein complex biogenesis (GO:0022613)2.83407737
94spindle assembly checkpoint (GO:0071173)2.81348591
95maturation of 5.8S rRNA (GO:0000460)2.81346807
96negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.81132725
97negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81132725
98negative regulation of mitotic sister chromatid segregation (GO:0033048)2.81132725
99negative regulation of mitotic sister chromatid separation (GO:2000816)2.81132725
100negative regulation of sister chromatid segregation (GO:0033046)2.81132725

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.82347899
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.51389837
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.21802067
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.09104012
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.65728599
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.38690772
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.30936821
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.21202222
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.07091700
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.70308977
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.65178902
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.56405705
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.47522515
14AR_21909140_ChIP-Seq_LNCAP_Human2.44099618
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.43123894
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34947863
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.31029187
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.30667378
19GATA1_22025678_ChIP-Seq_K562_Human2.27953660
20XRN2_22483619_ChIP-Seq_HELA_Human2.24613300
21DCP1A_22483619_ChIP-Seq_HELA_Human2.22158009
22NCOR1_26117541_ChIP-Seq_K562_Human2.21930681
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.18562960
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.16794027
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11584215
26PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.08279308
27ELK1_19687146_ChIP-ChIP_HELA_Human2.06030440
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04577550
29RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04169016
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97805374
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96650483
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95281675
33TTF2_22483619_ChIP-Seq_HELA_Human1.94867932
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.94335407
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88433025
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83411389
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82560310
38GATA1_19941826_ChIP-Seq_K562_Human1.79699087
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75975139
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72364410
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66109027
42VDR_23849224_ChIP-Seq_CD4+_Human1.61835185
43FOXP3_21729870_ChIP-Seq_TREG_Human1.60592939
44KDM5A_27292631_Chip-Seq_BREAST_Human1.58871167
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58636681
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56590571
47GABP_19822575_ChIP-Seq_HepG2_Human1.49511082
48CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.44016674
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41141678
50CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40844630
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40239370
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.39188223
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38403454
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32457502
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30863897
56* GATA2_19941826_ChIP-Seq_K562_Human1.30431171
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.28395967
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25814040
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25747151
60ZNF263_19887448_ChIP-Seq_K562_Human1.25699441
61MYC_22102868_ChIP-Seq_BL_Human1.22488723
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17201736
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14728531
64CIITA_25753668_ChIP-Seq_RAJI_Human1.13207662
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11619901
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11266118
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11119895
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09686553
69CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08270564
70TFEB_21752829_ChIP-Seq_HELA_Human1.05937320
71HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04611159
72CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.04322332
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04078081
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02886099
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02079877
76CHD1_26751641_Chip-Seq_LNCaP_Human0.99460648
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99336960
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90236071
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89560418
80SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.87779649
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87528238
82SPI1_23127762_ChIP-Seq_K562_Human0.86963604
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85093832
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83740702
85WT1_19549856_ChIP-ChIP_CCG9911_Human0.81412837
86SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79511476
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79280513
88MYC_18940864_ChIP-ChIP_HL60_Human0.78400667
89NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.78166402
90TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77801097
91PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.77538889
92GATA4_21415370_ChIP-Seq_HL-1_Mouse0.75702542
93YY1_21170310_ChIP-Seq_MESCs_Mouse0.75207668
94SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.75078342
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.74701011
96SOX17_20123909_ChIP-Seq_XEN_Mouse0.73870597
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.72443205
98GATA1_22383799_ChIP-Seq_G1ME_Mouse0.71587396
99SCL_19346495_ChIP-Seq_HPC-7_Human0.70173036
100GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.69383922

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.56105699
2MP0004957_abnormal_blastocyst_morpholog4.27225999
3MP0004147_increased_porphyrin_level4.09619386
4MP0003111_abnormal_nucleus_morphology3.98630604
5MP0008058_abnormal_DNA_repair3.76394762
6MP0003693_abnormal_embryo_hatching3.73255115
7MP0009697_abnormal_copulation3.56193374
8MP0008995_early_reproductive_senescence3.30381507
9MP0008057_abnormal_DNA_replication3.16847996
10MP0005451_abnormal_body_composition3.12276739
11MP0003077_abnormal_cell_cycle2.94257240
12MP0008932_abnormal_embryonic_tissue2.89338637
13MP0008007_abnormal_cellular_replicative2.80954300
14MP0003656_abnormal_erythrocyte_physiolo2.63208727
15MP0000678_abnormal_parathyroid_gland2.52291824
16MP0003786_premature_aging2.49050212
17MP0002877_abnormal_melanocyte_morpholog2.08464841
18MP0010307_abnormal_tumor_latency1.98030526
19MP0001730_embryonic_growth_arrest1.94506759
20MP0000350_abnormal_cell_proliferation1.92338846
21MP0003718_maternal_effect1.84983208
22MP0001697_abnormal_embryo_size1.78224004
23MP0006035_abnormal_mitochondrial_morpho1.77040910
24MP0002396_abnormal_hematopoietic_system1.68144981
25MP0004233_abnormal_muscle_weight1.66793763
26MP0005380_embryogenesis_phenotype1.57438212
27MP0001672_abnormal_embryogenesis/_devel1.57438212
28MP0001545_abnormal_hematopoietic_system1.57097308
29MP0005397_hematopoietic_system_phenotyp1.57097308
30MP0006036_abnormal_mitochondrial_physio1.55870119
31MP0000313_abnormal_cell_death1.53087357
32MP0002009_preneoplasia1.52660516
33MP0002080_prenatal_lethality1.52575865
34MP0001661_extended_life_span1.46466554
35MP0003984_embryonic_growth_retardation1.45779408
36MP0004185_abnormal_adipocyte_glucose1.44598314
37MP0003186_abnormal_redox_activity1.42056607
38MP0005083_abnormal_biliary_tract1.40157457
39MP0002088_abnormal_embryonic_growth/wei1.39403588
40MP0003221_abnormal_cardiomyocyte_apopto1.36402826
41MP0004145_abnormal_muscle_electrophysio1.36052804
42MP0002132_abnormal_respiratory_system1.34261342
43MP0002086_abnormal_extraembryonic_tissu1.33321357
44MP0001727_abnormal_embryo_implantation1.32369877
45MP0003806_abnormal_nucleotide_metabolis1.26437234
46MP0004808_abnormal_hematopoietic_stem1.25867858
47MP0003890_abnormal_embryonic-extraembry1.25458515
48MP0005076_abnormal_cell_differentiation1.24636516
49MP0002084_abnormal_developmental_patter1.24063044
50MP0002210_abnormal_sex_determination1.23335827
51MP0001929_abnormal_gametogenesis1.21849276
52MP0010352_gastrointestinal_tract_polyps1.16117142
53MP0000358_abnormal_cell_content/1.14678240
54MP0003705_abnormal_hypodermis_morpholog1.12766406
55MP0002019_abnormal_tumor_incidence1.08055529
56MP0002085_abnormal_embryonic_tissue1.07619477
57MP0010234_abnormal_vibrissa_follicle1.06716179
58MP0004197_abnormal_fetal_growth/weight/1.04161197
59MP0001873_stomach_inflammation1.02994271
60MP0003385_abnormal_body_wall1.01764768
61MP0004264_abnormal_extraembryonic_tissu0.96904579
62MP0001881_abnormal_mammary_gland0.96216169
63MP0008775_abnormal_heart_ventricle0.93537569
64MP0002269_muscular_atrophy0.92189532
65MP0005636_abnormal_mineral_homeostasis0.88729910
66MP0001145_abnormal_male_reproductive0.87254814
67MP0003959_abnormal_lean_body0.87127667
68MP0002970_abnormal_white_adipose0.86835463
69MP0000703_abnormal_thymus_morphology0.85648317
70MP0005408_hypopigmentation0.85066090
71MP0009115_abnormal_fat_cell0.82402721
72MP0000653_abnormal_sex_gland0.81240596
73MP0003699_abnormal_female_reproductive0.80355781
74MP0009703_decreased_birth_body0.79820292
75MP0003698_abnormal_male_reproductive0.79051530
76MP0008961_abnormal_basal_metabolism0.77865366
77MP0000609_abnormal_liver_physiology0.76612515
78MP0003937_abnormal_limbs/digits/tail_de0.73514386
79MP0008770_decreased_survivor_rate0.72141592
80MP0002161_abnormal_fertility/fecundity0.68221567
81MP0003950_abnormal_plasma_membrane0.67985182
82MP0005384_cellular_phenotype0.65935287
83MP0001348_abnormal_lacrimal_gland0.64335247
84MP0000647_abnormal_sebaceous_gland0.63723026
85MP0000428_abnormal_craniofacial_morphol0.62980761
86MP0002249_abnormal_larynx_morphology0.62755427
87MP0009672_abnormal_birth_weight0.60888498
88MP0002722_abnormal_immune_system0.60671981
89MP0000747_muscle_weakness0.60583083
90MP0001529_abnormal_vocalization0.60134053
91MP0009931_abnormal_skin_appearance0.59932918
92MP0005332_abnormal_amino_acid0.59487485
93MP0009278_abnormal_bone_marrow0.59305917
94MP0000598_abnormal_liver_morphology0.55774781
95MP0001764_abnormal_homeostasis0.54514277
96MP0005621_abnormal_cell_physiology0.54452391
97MP0002398_abnormal_bone_marrow0.54075700
98MP0004134_abnormal_chest_morphology0.53892210
99MP0003123_paternal_imprinting0.53880575
100MP0004019_abnormal_vitamin_homeostasis0.53830200

Predicted human phenotypes

RankGene SetZ-score
1Cholecystitis (HP:0001082)6.46825475
2Abnormal gallbladder physiology (HP:0012438)6.46825475
3Truncus arteriosus (HP:0001660)5.42777713
4Chromsome breakage (HP:0040012)4.98218304
5Reticulocytosis (HP:0001923)4.89967079
6Ankyloglossia (HP:0010296)4.80016949
7Chromosomal breakage induced by crosslinking agents (HP:0003221)4.76115192
8Birth length less than 3rd percentile (HP:0003561)4.40681420
9Cortical dysplasia (HP:0002539)4.36015817
10Abnormality of reticulocytes (HP:0004312)4.21507074
11Polycythemia (HP:0001901)4.15215031
12Hyperthyroidism (HP:0000836)3.96195153
13Abnormality of glycolysis (HP:0004366)3.76542494
14Bowel incontinence (HP:0002607)3.58997880
15Acute myeloid leukemia (HP:0004808)3.51032490
16Abnormality of oral frenula (HP:0000190)3.50945727
17Increased serum pyruvate (HP:0003542)3.42785861
18Abnormal large intestine physiology (HP:0012700)3.41670697
19Hypertensive crisis (HP:0100735)3.38709529
20Poikilocytosis (HP:0004447)3.37269324
21Abnormality of homocysteine metabolism (HP:0010919)3.36264266
22Homocystinuria (HP:0002156)3.36264266
23Cholelithiasis (HP:0001081)3.24311568
24Abnormality of the heme biosynthetic pathway (HP:0010472)3.19795051
25Upper limb muscle weakness (HP:0003484)3.10690995
26Abnormal hemoglobin (HP:0011902)3.05618720
27Insomnia (HP:0100785)3.05157294
28Ileus (HP:0002595)3.02820639
29Myelodysplasia (HP:0002863)2.88114732
30Abnormal gallbladder morphology (HP:0012437)2.85937125
31Flat cornea (HP:0007720)2.84249530
32Abnormality of chromosome stability (HP:0003220)2.83891075
33Increased nuchal translucency (HP:0010880)2.80369870
34Pallor (HP:0000980)2.79790618
35Seborrheic dermatitis (HP:0001051)2.77844165
36Reticulocytopenia (HP:0001896)2.76980396
37Abnormality of the tricuspid valve (HP:0001702)2.75075441
38Abnormality of the preputium (HP:0100587)2.74823811
39Hypoparathyroidism (HP:0000829)2.67853219
40Abnormality of cochlea (HP:0000375)2.67259733
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.63940923
42Hyperbilirubinemia (HP:0002904)2.59801107
43Acanthocytosis (HP:0001927)2.57885754
44Small intestinal stenosis (HP:0012848)2.57395708
45Duodenal stenosis (HP:0100867)2.57395708
46Aplasia/Hypoplasia of the earlobes (HP:0009906)2.54640872
47Orthostatic hypotension (HP:0001278)2.47017580
48Sandal gap (HP:0001852)2.44540318
49Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.37626091
50Progressive external ophthalmoplegia (HP:0000590)2.32832966
51Tinnitus (HP:0000360)2.32461592
52Duplicated collecting system (HP:0000081)2.30369449
53Short middle phalanx of the 5th finger (HP:0004220)2.24069651
54Abnormality of the gallbladder (HP:0005264)2.22619560
55Cafe-au-lait spot (HP:0000957)2.20759076
56Diaphragmatic weakness (HP:0009113)2.20060743
57Atelectasis (HP:0100750)2.17805643
58Pheochromocytoma (HP:0002666)2.16379264
59Overlapping toe (HP:0001845)2.12218385
60Nonimmune hydrops fetalis (HP:0001790)2.09747663
61Abnormality of the carotid arteries (HP:0005344)2.09425156
62Abnormality of sulfur amino acid metabolism (HP:0004339)2.05471368
63Abnormality of the pons (HP:0007361)2.04531950
64Obsessive-compulsive behavior (HP:0000722)2.04344506
65Meckel diverticulum (HP:0002245)2.03869138
66Hypoplasia of the pons (HP:0012110)2.03586272
67Palpitations (HP:0001962)2.02643607
68Dysmetric saccades (HP:0000641)2.01103549
69Insidious onset (HP:0003587)1.99834074
70Termporal pattern (HP:0011008)1.99834074
71Peripheral hypomyelination (HP:0007182)1.98457802
72Abnormality of DNA repair (HP:0003254)1.96796995
73Aplasia/Hypoplasia of the thymus (HP:0010515)1.95419011
74Abnormality of the ileum (HP:0001549)1.95063987
75Abnormality of cells of the erythroid lineage (HP:0012130)1.94064868
76Abnormality of the renal collecting system (HP:0004742)1.93634421
77Macrocytic anemia (HP:0001972)1.92805832
78Nephroblastoma (Wilms tumor) (HP:0002667)1.91955521
79Morphological abnormality of the inner ear (HP:0011390)1.91363444
80Breech presentation (HP:0001623)1.86350049
81Abnormal lung lobation (HP:0002101)1.86158782
82Cheekbone underdevelopment (HP:0010669)1.82620075
83Abnormality of the duodenum (HP:0002246)1.82452728
84Male infertility (HP:0003251)1.80134248
85Neuroendocrine neoplasm (HP:0100634)1.78525264
86Sloping forehead (HP:0000340)1.77803128
87Attention deficit hyperactivity disorder (HP:0007018)1.77480011
88Embryonal renal neoplasm (HP:0011794)1.74533625
89Abnormally folded helix (HP:0008544)1.74463542
90Aplastic anemia (HP:0001915)1.74167725
91Angiofibromas (HP:0010615)1.72421553
92Adenoma sebaceum (HP:0009720)1.72421553
93Papillary thyroid carcinoma (HP:0002895)1.72140291
94Septate vagina (HP:0001153)1.70679966
95Choanal atresia (HP:0000453)1.70260903
96Long foot (HP:0001833)1.67987920
97Abnormality of methionine metabolism (HP:0010901)1.67894639
98Multiple enchondromatosis (HP:0005701)1.67795897
99Relative macrocephaly (HP:0004482)1.67723878
100Large hands (HP:0001176)1.62908206

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.32760792
2TTK3.86259449
3RIPK43.42061350
4MST43.38892336
5BMPR23.06580871
6KSR22.95160393
7PBK2.89900688
8BUB12.73307898
9TSSK62.55869213
10WEE12.53927769
11EEF2K2.53140739
12CDC72.46074279
13CLK12.29775470
14NEK12.17973669
15CCNB12.17433510
16NME12.16453387
17PLK42.16163542
18RAF12.15058389
19MAP3K22.14351822
20TNIK2.05485250
21BRSK22.02680107
22EIF2AK31.96541728
23NTRK31.91694809
24SRPK11.91395366
25SCYL21.81600286
26KSR11.80158275
27MST1R1.69417698
28NEK21.57442746
29MAP3K81.54630306
30CHEK21.48764550
31WNK41.44027713
32MKNK11.24331807
33PLK31.22264400
34BMX1.19026723
35STK31.11480314
36CDK121.10901015
37NME21.10478907
38ATR1.06386694
39BRSK11.04752734
40RPS6KB21.03812736
41ICK1.03701581
42STK101.02634902
43TRPM71.01969717
44ALK1.00351327
45CHEK10.95314613
46PLK10.91216859
47MKNK20.88024818
48PDK20.85789263
49STK40.85136465
50BRAF0.80771156
51ATM0.80033837
52BRD40.79356636
53MAPKAPK50.72419425
54EIF2AK20.71543807
55MAP3K40.70861870
56CDK10.70404717
57ERBB30.69554982
58CDK70.66767342
59FGFR10.66707996
60WNK10.65728716
61AURKB0.61533631
62CDK20.60620199
63ERBB40.57077061
64YES10.56861606
65JAK20.56540550
66MAP2K10.56444563
67LATS20.56160996
68LRRK20.55297862
69CSNK2A20.51492213
70RET0.49738137
71PASK0.46888581
72IRAK30.45078506
73CSNK1E0.42866695
74MET0.42563541
75CDK40.42154654
76NEK60.39485584
77PAK10.37887272
78CDK80.35323115
79ZAK0.34068360
80PIK3CG0.34038489
81PNCK0.33937975
82MTOR0.33333296
83AKT30.33130776
84AKT20.32851821
85MAP3K10.32267527
86CSNK2A10.31851066
87PKN20.30568635
88PIM10.27902420
89PRKDC0.27050691
90MAPK100.26576580
91MAP3K60.25850098
92RPS6KA40.24504643
93MAPK140.24072320
94BCR0.22270651
95GSK3B0.21768769
96DYRK30.20291815
97MARK30.19519691
98PAK20.19500896
99CAMK1D0.18948720
100PLK20.17232058

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009704.79491978
2DNA replication_Homo sapiens_hsa030303.55895767
3One carbon pool by folate_Homo sapiens_hsa006703.49537105
4Mismatch repair_Homo sapiens_hsa034303.44159496
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.23917754
6Homologous recombination_Homo sapiens_hsa034403.09205420
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.06879175
8RNA transport_Homo sapiens_hsa030132.67361153
9Cell cycle_Homo sapiens_hsa041102.55091588
10Nucleotide excision repair_Homo sapiens_hsa034202.44516318
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.38718595
12Spliceosome_Homo sapiens_hsa030402.35505316
13Non-homologous end-joining_Homo sapiens_hsa034502.29340963
14Fanconi anemia pathway_Homo sapiens_hsa034602.14122605
15Basal transcription factors_Homo sapiens_hsa030222.00586210
16Pyruvate metabolism_Homo sapiens_hsa006201.95713803
17Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.81245850
18Ribosome_Homo sapiens_hsa030101.79129615
19Biosynthesis of amino acids_Homo sapiens_hsa012301.76482910
20mRNA surveillance pathway_Homo sapiens_hsa030151.69174960
21Carbon metabolism_Homo sapiens_hsa012001.57720338
22RNA degradation_Homo sapiens_hsa030181.55555905
23Base excision repair_Homo sapiens_hsa034101.49161192
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.46629138
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44664134
26* Olfactory transduction_Homo sapiens_hsa047401.37814693
27Thyroid cancer_Homo sapiens_hsa052161.37134990
28Proteasome_Homo sapiens_hsa030501.33044740
29RNA polymerase_Homo sapiens_hsa030201.29609463
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28324528
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17563577
32Chronic myeloid leukemia_Homo sapiens_hsa052201.15812339
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14056760
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11194781
35Steroid biosynthesis_Homo sapiens_hsa001001.09817554
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.08033632
37Pyrimidine metabolism_Homo sapiens_hsa002401.05095420
38Acute myeloid leukemia_Homo sapiens_hsa052211.03141572
39Oocyte meiosis_Homo sapiens_hsa041141.02273263
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01760032
41Pentose phosphate pathway_Homo sapiens_hsa000300.99632664
42Selenocompound metabolism_Homo sapiens_hsa004500.99000367
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93436505
44Fructose and mannose metabolism_Homo sapiens_hsa000510.93132079
45Vitamin B6 metabolism_Homo sapiens_hsa007500.91304300
46Propanoate metabolism_Homo sapiens_hsa006400.90881850
47Purine metabolism_Homo sapiens_hsa002300.88174414
48ErbB signaling pathway_Homo sapiens_hsa040120.87789947
49Pancreatic cancer_Homo sapiens_hsa052120.84427124
50Arginine biosynthesis_Homo sapiens_hsa002200.82076315
51Viral carcinogenesis_Homo sapiens_hsa052030.81838456
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78263244
53Fatty acid biosynthesis_Homo sapiens_hsa000610.78248275
54Type II diabetes mellitus_Homo sapiens_hsa049300.73519530
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73045939
56mTOR signaling pathway_Homo sapiens_hsa041500.69808372
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.68204080
58Renal cell carcinoma_Homo sapiens_hsa052110.64986631
59Non-small cell lung cancer_Homo sapiens_hsa052230.63902216
60Protein export_Homo sapiens_hsa030600.60045022
61Fatty acid metabolism_Homo sapiens_hsa012120.55320572
62MicroRNAs in cancer_Homo sapiens_hsa052060.54177313
63VEGF signaling pathway_Homo sapiens_hsa043700.53869069
64p53 signaling pathway_Homo sapiens_hsa041150.53792749
65Epstein-Barr virus infection_Homo sapiens_hsa051690.52373549
66HIF-1 signaling pathway_Homo sapiens_hsa040660.51607435
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49384539
68Huntingtons disease_Homo sapiens_hsa050160.49324380
69Parkinsons disease_Homo sapiens_hsa050120.46623947
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42586790
71Insulin signaling pathway_Homo sapiens_hsa049100.40909819
72Glutathione metabolism_Homo sapiens_hsa004800.40027165
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.38087482
74Glioma_Homo sapiens_hsa052140.37683425
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36804733
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32686865
77Prion diseases_Homo sapiens_hsa050200.31744861
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31070427
79Adherens junction_Homo sapiens_hsa045200.30850193
80Hepatitis B_Homo sapiens_hsa051610.30587131
81Colorectal cancer_Homo sapiens_hsa052100.30167544
82Butanoate metabolism_Homo sapiens_hsa006500.30032345
83N-Glycan biosynthesis_Homo sapiens_hsa005100.28016901
84Metabolic pathways_Homo sapiens_hsa011000.27718406
85Bladder cancer_Homo sapiens_hsa052190.26626111
86Shigellosis_Homo sapiens_hsa051310.25309164
87Prostate cancer_Homo sapiens_hsa052150.24451201
88Oxidative phosphorylation_Homo sapiens_hsa001900.23570916
89Prolactin signaling pathway_Homo sapiens_hsa049170.23181462
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20739215
91Lysine degradation_Homo sapiens_hsa003100.20000827
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18356754
93HTLV-I infection_Homo sapiens_hsa051660.16132399
94Folate biosynthesis_Homo sapiens_hsa007900.15857740
95B cell receptor signaling pathway_Homo sapiens_hsa046620.15104355
96Endometrial cancer_Homo sapiens_hsa052130.14921136
97Arginine and proline metabolism_Homo sapiens_hsa003300.14019644
98Inositol phosphate metabolism_Homo sapiens_hsa005620.13625331
99Herpes simplex infection_Homo sapiens_hsa051680.12614219
100Alcoholism_Homo sapiens_hsa050340.12067028

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