OR51B5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)8.18839921
2nuclear pore organization (GO:0006999)7.30388045
3pore complex assembly (GO:0046931)6.11819523
4oxygen transport (GO:0015671)5.77410939
5regulation of translational fidelity (GO:0006450)5.59138206
6gas transport (GO:0015669)5.56470841
7DNA replication checkpoint (GO:0000076)5.33114405
8DNA unwinding involved in DNA replication (GO:0006268)4.93954146
9protoporphyrinogen IX metabolic process (GO:0046501)4.88754828
10DNA topological change (GO:0006265)4.86763823
11mitotic sister chromatid segregation (GO:0000070)4.86043550
12regulation of RNA export from nucleus (GO:0046831)4.84364146
13mitotic nuclear envelope disassembly (GO:0007077)4.79641311
14regulation of histone H3-K4 methylation (GO:0051569)4.77806337
15sister chromatid segregation (GO:0000819)4.73489285
16mitotic chromosome condensation (GO:0007076)4.55315737
17membrane disassembly (GO:0030397)4.45209603
18nuclear envelope disassembly (GO:0051081)4.45209603
19protoporphyrinogen IX biosynthetic process (GO:0006782)4.43461540
20DNA replication initiation (GO:0006270)4.43046818
21synapsis (GO:0007129)4.29369598
22diterpenoid biosynthetic process (GO:0016102)4.23251267
23regulation of mitotic spindle organization (GO:0060236)4.23201696
24ribosome assembly (GO:0042255)4.21935264
25regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.15513044
26DNA strand elongation involved in DNA replication (GO:0006271)4.13688996
27protein localization to kinetochore (GO:0034501)4.12073510
28formation of translation preinitiation complex (GO:0001731)4.08095528
29negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.05165938
30DNA strand elongation (GO:0022616)4.02607826
31protein localization to chromosome, centromeric region (GO:0071459)4.01220019
32meiotic chromosome segregation (GO:0045132)3.96601599
33regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.92932246
34regulation of nucleobase-containing compound transport (GO:0032239)3.88326287
35regulation of histone H3-K27 methylation (GO:0061085)3.86999888
36resolution of meiotic recombination intermediates (GO:0000712)3.83133815
37erythrocyte maturation (GO:0043249)3.79846107
38tRNA aminoacylation for protein translation (GO:0006418)3.77248603
39positive regulation of histone H3-K4 methylation (GO:0051571)3.68150050
40folic acid-containing compound biosynthetic process (GO:0009396)3.65662817
41tRNA aminoacylation (GO:0043039)3.64436566
42amino acid activation (GO:0043038)3.64436566
43mitotic metaphase plate congression (GO:0007080)3.64204054
44telomere maintenance via semi-conservative replication (GO:0032201)3.64165672
45homocysteine metabolic process (GO:0050667)3.62709353
46microtubule depolymerization (GO:0007019)3.55076268
47chromosome segregation (GO:0007059)3.54008524
48purine nucleobase biosynthetic process (GO:0009113)3.53837606
49regulation of histone methylation (GO:0031060)3.52905284
50regulation of spindle organization (GO:0090224)3.52374347
51terpenoid biosynthetic process (GO:0016114)3.49337453
52mitotic recombination (GO:0006312)3.42159822
53IMP biosynthetic process (GO:0006188)3.42060300
54regulation of centriole replication (GO:0046599)3.40753623
55regulation of retinoic acid receptor signaling pathway (GO:0048385)3.39299035
56* detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.35687722
57regulation of translational elongation (GO:0006448)3.34500936
58vitamin A metabolic process (GO:0006776)3.33231221
59telomere maintenance via recombination (GO:0000722)3.29444795
60tetrahydrofolate metabolic process (GO:0046653)3.27070856
61proline biosynthetic process (GO:0006561)3.26597404
62negative regulation of histone methylation (GO:0031061)3.25377045
63nuclear envelope organization (GO:0006998)3.23741513
64regulation of histone H3-K9 methylation (GO:0051570)3.21996777
65regulation of centrosome cycle (GO:0046605)3.21741309
66chromosome condensation (GO:0030261)3.16106670
67nucleobase biosynthetic process (GO:0046112)3.16087869
68COPI coating of Golgi vesicle (GO:0048205)3.12914609
69Golgi transport vesicle coating (GO:0048200)3.12914609
70* sensory perception of smell (GO:0007608)3.12568109
71centriole replication (GO:0007099)3.11400750
72definitive hemopoiesis (GO:0060216)3.09603404
73oxidative phosphorylation (GO:0006119)3.07904791
74intra-S DNA damage checkpoint (GO:0031573)3.07840891
75regulation of chromosome segregation (GO:0051983)3.06583816
76protein export from nucleus (GO:0006611)3.04243900
77metaphase plate congression (GO:0051310)3.02843291
78positive regulation of chromosome segregation (GO:0051984)2.99060674
79regulation of DNA methylation (GO:0044030)2.97664067
80positive regulation of histone methylation (GO:0031062)2.95327832
81mitotic spindle checkpoint (GO:0071174)2.95218477
82IMP metabolic process (GO:0046040)2.92929211
83DNA conformation change (GO:0071103)2.92204390
84negative regulation of chromosome segregation (GO:0051985)2.89745368
85DNA packaging (GO:0006323)2.89635160
86DNA methylation involved in gamete generation (GO:0043046)2.89430836
87positive regulation of megakaryocyte differentiation (GO:0045654)2.89342099
88mitotic spindle assembly checkpoint (GO:0007094)2.85705206
89negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.84508272
90negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.84508272
91negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84508272
92negative regulation of mitotic sister chromatid separation (GO:2000816)2.84508272
93negative regulation of sister chromatid segregation (GO:0033046)2.84508272
94centriole assembly (GO:0098534)2.84002386
95histone phosphorylation (GO:0016572)2.83291301
96mitotic G2/M transition checkpoint (GO:0044818)2.83006402
97spindle assembly checkpoint (GO:0071173)2.81556313
98negative regulation of potassium ion transmembrane transport (GO:1901380)2.81546901
99spindle checkpoint (GO:0031577)2.80698184
100kinetochore organization (GO:0051383)2.80446354

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.68925305
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.06785292
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.84030643
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.44602548
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.23306531
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.23305534
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.19824365
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.00549018
9NCOR1_26117541_ChIP-Seq_K562_Human2.59994623
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.58851255
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.58179732
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.47131642
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.43147587
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40608544
15GATA1_22025678_ChIP-Seq_K562_Human2.39911605
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.32989663
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.32415927
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.30638780
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28476899
20XRN2_22483619_ChIP-Seq_HELA_Human2.22083682
21AR_21909140_ChIP-Seq_LNCAP_Human2.18690109
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.14967792
23DCP1A_22483619_ChIP-Seq_HELA_Human2.13442439
24GABP_17652178_ChIP-ChIP_JURKAT_Human2.12844690
25GATA1_19941826_ChIP-Seq_K562_Human2.11831962
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04037283
27E2F7_22180533_ChIP-Seq_HELA_Human10.1189887
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97381265
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.97074183
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96998299
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96295311
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.96091041
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.92059848
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85070803
35TTF2_22483619_ChIP-Seq_HELA_Human1.84611214
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82179547
37ELK1_19687146_ChIP-ChIP_HELA_Human1.74808895
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72195973
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70067844
40FOXP3_21729870_ChIP-Seq_TREG_Human1.66735551
41VDR_23849224_ChIP-Seq_CD4+_Human1.64520803
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63761126
43KDM5A_27292631_Chip-Seq_BREAST_Human1.55545954
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51907894
45GATA2_19941826_ChIP-Seq_K562_Human1.50891204
46GABP_19822575_ChIP-Seq_HepG2_Human1.47813399
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46239637
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.42638071
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42528052
50CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.41320484
51CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.38678503
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34654301
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.34553326
54ZNF263_19887448_ChIP-Seq_K562_Human1.33907431
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31971887
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28554218
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26062524
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23878934
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23011781
60MYC_22102868_ChIP-Seq_BL_Human1.21851291
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21385079
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.17716524
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15812293
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13831059
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13359247
66SPI1_23127762_ChIP-Seq_K562_Human1.13317241
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11083869
68CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10671563
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09554067
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.09424241
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07829240
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05621408
73CIITA_25753668_ChIP-Seq_RAJI_Human1.05356041
74CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00453160
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98271881
76TFEB_21752829_ChIP-Seq_HELA_Human0.98073976
77HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97430851
78SCL_19346495_ChIP-Seq_HPC-7_Human0.96323836
79WT1_19549856_ChIP-ChIP_CCG9911_Human0.96245192
80VDR_22108803_ChIP-Seq_LS180_Human0.95923452
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95666505
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95043969
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92945620
84ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91962710
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89944836
86CHD1_26751641_Chip-Seq_LNCaP_Human0.88087373
87GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.87681829
88GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86361476
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.85742529
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84173197
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81016596
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79896269
93TBX5_21415370_ChIP-Seq_HL-1_Mouse0.79055203
94PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.76422040
95PKCTHETA_26484144_Chip-Seq_BREAST_Human0.75466832
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.75034380
97SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74429261
98SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.72977773
99PHF8_20622853_ChIP-Seq_HELA_Human0.71851771
100GATA6_21074721_ChIP-Seq_CACO-2_Human0.71226923

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level4.23072789
2MP0010094_abnormal_chromosome_stability4.17031536
3MP0004957_abnormal_blastocyst_morpholog3.97251947
4MP0008058_abnormal_DNA_repair3.97119681
5MP0003111_abnormal_nucleus_morphology3.83246734
6MP0003693_abnormal_embryo_hatching3.74935651
7MP0008995_early_reproductive_senescence3.70468584
8MP0008057_abnormal_DNA_replication3.61728123
9MP0009697_abnormal_copulation3.48174494
10MP0003656_abnormal_erythrocyte_physiolo3.05097527
11MP0003077_abnormal_cell_cycle2.91601884
12MP0003718_maternal_effect2.80930196
13MP0003786_premature_aging2.70037775
14MP0008932_abnormal_embryonic_tissue2.69891360
15MP0005451_abnormal_body_composition2.55342624
16MP0000678_abnormal_parathyroid_gland2.47883990
17MP0008007_abnormal_cellular_replicative2.39686686
18MP0005397_hematopoietic_system_phenotyp2.09356925
19MP0001545_abnormal_hematopoietic_system2.09356925
20MP0000372_irregular_coat_pigmentation1.97250754
21MP0000350_abnormal_cell_proliferation1.89797344
22MP0010307_abnormal_tumor_latency1.88919862
23MP0001730_embryonic_growth_arrest1.81521233
24MP0002396_abnormal_hematopoietic_system1.78459265
25MP0004233_abnormal_muscle_weight1.76937570
26MP0005083_abnormal_biliary_tract1.76586070
27MP0001697_abnormal_embryo_size1.68221314
28MP0006036_abnormal_mitochondrial_physio1.61760653
29MP0001672_abnormal_embryogenesis/_devel1.58100160
30MP0005380_embryogenesis_phenotype1.58100160
31MP0002210_abnormal_sex_determination1.57925565
32MP0006035_abnormal_mitochondrial_morpho1.56852244
33MP0001929_abnormal_gametogenesis1.54913024
34MP0002132_abnormal_respiratory_system1.54386317
35MP0000313_abnormal_cell_death1.50728179
36MP0001661_extended_life_span1.49860152
37MP0004145_abnormal_muscle_electrophysio1.46265268
38MP0003984_embryonic_growth_retardation1.43644158
39MP0002080_prenatal_lethality1.41011724
40MP0002088_abnormal_embryonic_growth/wei1.36641094
41MP0003950_abnormal_plasma_membrane1.33163104
42MP0003890_abnormal_embryonic-extraembry1.30358518
43MP0002877_abnormal_melanocyte_morpholog1.30081753
44MP0003186_abnormal_redox_activity1.23397558
45MP0002086_abnormal_extraembryonic_tissu1.23285306
46MP0003806_abnormal_nucleotide_metabolis1.19553442
47MP0009278_abnormal_bone_marrow1.18834509
48MP0002139_abnormal_hepatobiliary_system1.11825439
49MP0004808_abnormal_hematopoietic_stem1.11105351
50MP0003699_abnormal_female_reproductive1.09365313
51MP0001873_stomach_inflammation1.07184035
52MP0001145_abnormal_male_reproductive1.06633206
53MP0000653_abnormal_sex_gland1.06056727
54MP0003221_abnormal_cardiomyocyte_apopto1.05587531
55MP0002269_muscular_atrophy1.04825665
56MP0002019_abnormal_tumor_incidence1.04416976
57MP0005408_hypopigmentation1.03291223
58MP0003698_abnormal_male_reproductive1.03199808
59MP0000358_abnormal_cell_content/1.02975830
60MP0002084_abnormal_developmental_patter1.02921766
61MP0003646_muscle_fatigue1.00061783
62MP0005076_abnormal_cell_differentiation0.98151303
63MP0005410_abnormal_fertilization0.97087151
64MP0002009_preneoplasia0.94837117
65MP0003959_abnormal_lean_body0.94006154
66MP0006292_abnormal_olfactory_placode0.93993630
67MP0008775_abnormal_heart_ventricle0.93697962
68MP0002085_abnormal_embryonic_tissue0.92742534
69MP0001881_abnormal_mammary_gland0.91429011
70MP0004885_abnormal_endolymph0.90966900
71MP0010234_abnormal_vibrissa_follicle0.88708896
72MP0005636_abnormal_mineral_homeostasis0.88166778
73MP0002161_abnormal_fertility/fecundity0.88034006
74MP0000647_abnormal_sebaceous_gland0.87725328
75MP0000703_abnormal_thymus_morphology0.84108929
76MP0001727_abnormal_embryo_implantation0.80055070
77MP0004185_abnormal_adipocyte_glucose0.78268926
78MP0002095_abnormal_skin_pigmentation0.75549862
79MP0003385_abnormal_body_wall0.71909114
80MP0004197_abnormal_fetal_growth/weight/0.71271329
81MP0001188_hyperpigmentation0.67434295
82MP0005395_other_phenotype0.66507859
83MP0001529_abnormal_vocalization0.64928749
84MP0001119_abnormal_female_reproductive0.62655057
85MP0009703_decreased_birth_body0.62543057
86MP0008770_decreased_survivor_rate0.61525810
87MP0002970_abnormal_white_adipose0.60445412
88MP0002722_abnormal_immune_system0.59879861
89MP0000609_abnormal_liver_physiology0.58900597
90MP0002398_abnormal_bone_marrow0.57346694
91MP0003567_abnormal_fetal_cardiomyocyte0.56191091
92MP0002249_abnormal_larynx_morphology0.56005430
93MP0005647_abnormal_sex_gland0.55650520
94MP0009931_abnormal_skin_appearance0.54573247
95MP0005384_cellular_phenotype0.54350245
96MP0005187_abnormal_penis_morphology0.53133777
97MP0004084_abnormal_cardiac_muscle0.52639917
98MP0004019_abnormal_vitamin_homeostasis0.51736397
99MP0005171_absent_coat_pigmentation0.51223373
100MP0009672_abnormal_birth_weight0.50711911

Predicted human phenotypes

RankGene SetZ-score
1Abnormal gallbladder physiology (HP:0012438)7.05509371
2Cholecystitis (HP:0001082)7.05509371
3Truncus arteriosus (HP:0001660)5.89168981
4Reticulocytosis (HP:0001923)5.36505276
5Abnormal hemoglobin (HP:0011902)4.84023561
6Abnormality of the heme biosynthetic pathway (HP:0010472)4.80365781
7Hyperthyroidism (HP:0000836)4.67965544
8Birth length less than 3rd percentile (HP:0003561)4.56106255
9Abnormality of reticulocytes (HP:0004312)4.49144932
10Polycythemia (HP:0001901)4.48430286
11Chromsome breakage (HP:0040012)4.47425696
12Ankyloglossia (HP:0010296)4.38629135
13Chromosomal breakage induced by crosslinking agents (HP:0003221)4.26852921
14Bowel incontinence (HP:0002607)4.01742986
15Hypertensive crisis (HP:0100735)3.88663955
16Abnormal large intestine physiology (HP:0012700)3.82995798
17Ileus (HP:0002595)3.68320158
18Pallor (HP:0000980)3.31448993
19Abnormality of cochlea (HP:0000375)3.29514878
20Abnormality of homocysteine metabolism (HP:0010919)3.29321454
21Homocystinuria (HP:0002156)3.29321454
22Seborrheic dermatitis (HP:0001051)3.28364328
23Cholelithiasis (HP:0001081)3.24392519
24Poikilocytosis (HP:0004447)3.24351590
25Acute myeloid leukemia (HP:0004808)3.19441265
26Cortical dysplasia (HP:0002539)3.16907675
27Abnormality of oral frenula (HP:0000190)3.01632003
28Hypoparathyroidism (HP:0000829)2.95277811
29Abnormality of the tricuspid valve (HP:0001702)2.94692657
30Abnormality of glycolysis (HP:0004366)2.87719139
31Abnormal gallbladder morphology (HP:0012437)2.85406482
32Myelodysplasia (HP:0002863)2.81419788
33Acanthocytosis (HP:0001927)2.80687613
34Upper limb muscle weakness (HP:0003484)2.79896211
35Aplasia/Hypoplasia of the earlobes (HP:0009906)2.79827597
36Atelectasis (HP:0100750)2.67868245
37Increased serum pyruvate (HP:0003542)2.67658241
38Breech presentation (HP:0001623)2.67167204
39Abnormality of chromosome stability (HP:0003220)2.66645396
40Reticulocytopenia (HP:0001896)2.64717540
41Abnormality of the preputium (HP:0100587)2.61901844
42Abnormality of the gallbladder (HP:0005264)2.55268723
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.51907737
44Small intestinal stenosis (HP:0012848)2.46201674
45Duodenal stenosis (HP:0100867)2.46201674
46Hyperbilirubinemia (HP:0002904)2.44402873
47Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.43958053
48Morphological abnormality of the inner ear (HP:0011390)2.42563467
49Nonimmune hydrops fetalis (HP:0001790)2.39936752
50Increased nuchal translucency (HP:0010880)2.36517904
51Male infertility (HP:0003251)2.32144008
52Insomnia (HP:0100785)2.31621731
53Duplicated collecting system (HP:0000081)2.28169980
54Overlapping toe (HP:0001845)2.27214978
55Sandal gap (HP:0001852)2.21757868
56Premature ovarian failure (HP:0008209)2.20710710
57Progressive external ophthalmoplegia (HP:0000590)2.17844268
58Aplasia/Hypoplasia of the thymus (HP:0010515)2.13744042
59Cafe-au-lait spot (HP:0000957)2.11762060
60Cheekbone underdevelopment (HP:0010669)2.10102921
61Flat cornea (HP:0007720)2.06887499
62Abnormally folded helix (HP:0008544)2.05095263
63Diaphragmatic weakness (HP:0009113)2.00476661
64Meckel diverticulum (HP:0002245)1.99117000
65Relative macrocephaly (HP:0004482)1.98634421
66Abnormal lung lobation (HP:0002101)1.94424137
67Peripheral hypomyelination (HP:0007182)1.91845154
68Abnormality of the renal collecting system (HP:0004742)1.91774534
69Orthostatic hypotension (HP:0001278)1.89833477
70Abnormality of cells of the erythroid lineage (HP:0012130)1.89663323
71Dysmetric saccades (HP:0000641)1.89526488
72Abnormality of sulfur amino acid metabolism (HP:0004339)1.88982237
73Abnormality of DNA repair (HP:0003254)1.88626094
74Tinnitus (HP:0000360)1.88141100
75Short middle phalanx of the 5th finger (HP:0004220)1.87724719
76Submucous cleft hard palate (HP:0000176)1.86739860
77Abnormality of the ileum (HP:0001549)1.85240668
78Abnormality of the carotid arteries (HP:0005344)1.84381366
79Abnormality of the fingertips (HP:0001211)1.83244333
80Obsessive-compulsive behavior (HP:0000722)1.80899048
81Breast hypoplasia (HP:0003187)1.79885306
82Abnormality of the duodenum (HP:0002246)1.75797413
83Macrocytic anemia (HP:0001972)1.72587045
84Abnormal number of erythroid precursors (HP:0012131)1.70643718
85Attention deficit hyperactivity disorder (HP:0007018)1.69258431
86Septate vagina (HP:0001153)1.69078380
87Nausea (HP:0002018)1.65979271
88Abnormality of the labia minora (HP:0012880)1.65756662
89Fatigue (HP:0012378)1.62920868
90Papillary thyroid carcinoma (HP:0002895)1.62836966
91Esophageal neoplasm (HP:0100751)1.62761639
92Neoplasm of head and neck (HP:0012288)1.62761639
93Arteriovenous malformation (HP:0100026)1.61662675
94Complete atrioventricular canal defect (HP:0001674)1.60522132
95Aplastic anemia (HP:0001915)1.59931078
96Deep philtrum (HP:0002002)1.59721390
97Patellar dislocation (HP:0002999)1.59670643
98Disproportionate tall stature (HP:0001519)1.57617336
99Bone marrow hypocellularity (HP:0005528)1.57021983
100Delayed myelination (HP:0012448)1.56637041

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTK3.86216563
2EIF2AK13.70140468
3RIPK43.63138777
4KSR23.59669208
5AKT32.98005058
6PLK42.83747391
7BMPR22.70974531
8EEF2K2.65968056
9CDC72.56407908
10RAF12.55807674
11CLK12.45757113
12BRSK22.40401870
13MAP3K22.37807800
14BUB12.36350124
15WEE12.35888137
16NTRK32.31455629
17NEK12.28704950
18CCNB12.28443203
19BRAF2.17231180
20TSSK62.06650404
21MST42.03757078
22KSR11.95022234
23NME11.94460714
24PBK1.90107562
25NEK21.77189931
26EIF2AK31.76769528
27SRPK11.74004064
28CDK121.60476793
29MAP3K81.57682817
30BMX1.44411050
31BRSK11.42971406
32CHEK21.34532608
33SCYL21.31186651
34TNIK1.12934821
35PLK31.12442556
36WNK41.10882729
37ATR1.07801938
38CHEK11.04010117
39STK31.00540584
40RPS6KB20.99284317
41PLK10.92433308
42ICK0.88643819
43ATM0.86098681
44STK40.84868198
45WNK10.83691788
46TRPM70.83356331
47MAP3K40.80815567
48IRAK30.79850298
49CDK10.74294327
50AURKB0.72722672
51RPS6KA40.71767480
52PDK20.71639101
53BRD40.69564222
54CDK20.68930458
55STK100.67169623
56ALK0.65453871
57MAP3K130.63924714
58PAK10.63121824
59NEK60.60869352
60MAP2K10.60285548
61DYRK30.60012921
62MARK30.58298669
63NME20.57953320
64EIF2AK20.56569258
65JAK20.56509490
66CSNK2A20.54267881
67MAPKAPK50.54118438
68ZAK0.52991232
69CDK70.51926925
70RET0.49993203
71PIM10.49528626
72AURKA0.49330026
73ARAF0.47404498
74MKNK10.47048322
75MAP3K10.46769399
76LRRK20.46687814
77CSNK1E0.45842792
78YES10.44504689
79PIK3CG0.42518584
80MST1R0.41254302
81MAP3K90.40971755
82MTOR0.40963250
83LATS20.38957087
84CDK40.33612209
85CSNK2A10.33143993
86SGK10.31624909
87JAK30.30397830
88MAPK100.30280996
89AKT20.29932294
90GSK3B0.28796501
91TEC0.28570837
92PRKDC0.27491486
93MET0.26950544
94MAP3K100.26878336
95PRKAA10.25013697
96RPS6KA50.24788346
97MAPK140.24736642
98PLK20.24182124
99CDK30.24169030
100DMPK0.21790262

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009704.45147981
2Mismatch repair_Homo sapiens_hsa034303.68621228
3DNA replication_Homo sapiens_hsa030303.64278835
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.55881440
5Homologous recombination_Homo sapiens_hsa034403.28444261
6One carbon pool by folate_Homo sapiens_hsa006703.24753961
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.86909393
8RNA transport_Homo sapiens_hsa030132.71566432
9Cell cycle_Homo sapiens_hsa041102.67217698
10Fanconi anemia pathway_Homo sapiens_hsa034602.37317678
11Basal transcription factors_Homo sapiens_hsa030222.36092007
12Nucleotide excision repair_Homo sapiens_hsa034202.33997996
13Spliceosome_Homo sapiens_hsa030402.11816788
14Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.11773211
15Ribosome_Homo sapiens_hsa030102.09401008
16mRNA surveillance pathway_Homo sapiens_hsa030151.85794828
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.77204795
18* Olfactory transduction_Homo sapiens_hsa047401.73811577
19Pyruvate metabolism_Homo sapiens_hsa006201.70749257
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.69641136
21Thyroid cancer_Homo sapiens_hsa052161.57671642
22Non-homologous end-joining_Homo sapiens_hsa034501.55701973
23Biosynthesis of amino acids_Homo sapiens_hsa012301.54693027
24RNA degradation_Homo sapiens_hsa030181.51221274
25Steroid biosynthesis_Homo sapiens_hsa001001.47909309
26RNA polymerase_Homo sapiens_hsa030201.45681106
27Base excision repair_Homo sapiens_hsa034101.39976379
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.37652622
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36166152
30Carbon metabolism_Homo sapiens_hsa012001.33808294
31Oocyte meiosis_Homo sapiens_hsa041141.31289145
32Acute myeloid leukemia_Homo sapiens_hsa052211.29618251
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26769816
34Chronic myeloid leukemia_Homo sapiens_hsa052201.15260077
35Arginine biosynthesis_Homo sapiens_hsa002201.10802935
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00720399
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98670209
38Fructose and mannose metabolism_Homo sapiens_hsa000510.92163277
39mTOR signaling pathway_Homo sapiens_hsa041500.91914953
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90296182
41Pyrimidine metabolism_Homo sapiens_hsa002400.89043165
42ErbB signaling pathway_Homo sapiens_hsa040120.88355640
43Non-small cell lung cancer_Homo sapiens_hsa052230.87770171
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85932801
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85097608
46Purine metabolism_Homo sapiens_hsa002300.83371502
47Pancreatic cancer_Homo sapiens_hsa052120.83206672
48Propanoate metabolism_Homo sapiens_hsa006400.79815740
49Proteasome_Homo sapiens_hsa030500.79551417
50Renal cell carcinoma_Homo sapiens_hsa052110.76572589
51Butanoate metabolism_Homo sapiens_hsa006500.75445324
52Type II diabetes mellitus_Homo sapiens_hsa049300.74815949
53Pentose phosphate pathway_Homo sapiens_hsa000300.73567671
54Viral carcinogenesis_Homo sapiens_hsa052030.72051790
55Selenocompound metabolism_Homo sapiens_hsa004500.69086910
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67578648
57Parkinsons disease_Homo sapiens_hsa050120.61074027
58VEGF signaling pathway_Homo sapiens_hsa043700.61010642
59HIF-1 signaling pathway_Homo sapiens_hsa040660.60604223
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60017480
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58419061
62Huntingtons disease_Homo sapiens_hsa050160.57305268
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55582576
64Insulin signaling pathway_Homo sapiens_hsa049100.53117775
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.53086451
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.51652460
67MicroRNAs in cancer_Homo sapiens_hsa052060.49576424
68Bladder cancer_Homo sapiens_hsa052190.47182602
69Fatty acid metabolism_Homo sapiens_hsa012120.45004183
70Fatty acid biosynthesis_Homo sapiens_hsa000610.44468842
71Glioma_Homo sapiens_hsa052140.44329236
72Protein export_Homo sapiens_hsa030600.43992124
73Oxidative phosphorylation_Homo sapiens_hsa001900.43700696
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41117488
75Epstein-Barr virus infection_Homo sapiens_hsa051690.40984036
76Prolactin signaling pathway_Homo sapiens_hsa049170.36431949
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35222470
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33336014
79p53 signaling pathway_Homo sapiens_hsa041150.30198275
80Prion diseases_Homo sapiens_hsa050200.28438160
81Vitamin B6 metabolism_Homo sapiens_hsa007500.27053026
82Metabolic pathways_Homo sapiens_hsa011000.26806659
83Colorectal cancer_Homo sapiens_hsa052100.26333427
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26022371
85Glutathione metabolism_Homo sapiens_hsa004800.25042977
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23950828
87Hepatitis B_Homo sapiens_hsa051610.23192778
88N-Glycan biosynthesis_Homo sapiens_hsa005100.22493493
89Endometrial cancer_Homo sapiens_hsa052130.19779269
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.19737844
91Fatty acid elongation_Homo sapiens_hsa000620.19736359
92B cell receptor signaling pathway_Homo sapiens_hsa046620.19291999
93Prostate cancer_Homo sapiens_hsa052150.17361876
94Long-term potentiation_Homo sapiens_hsa047200.15762240
95Alcoholism_Homo sapiens_hsa050340.15526482
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.14386099
97Lysine degradation_Homo sapiens_hsa003100.13679845
98Other glycan degradation_Homo sapiens_hsa005110.13582411
99Inositol phosphate metabolism_Homo sapiens_hsa005620.13462068
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.11633515

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