ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	5.69337191
2	sensory perception of smell (GO:0007608)	4.83307058
3	regulation of DNA endoreduplication (GO:0032875)	3.99670239
4	mitotic metaphase plate congression (GO:0007080)	3.99348197
5	centriole replication (GO:0007099)	3.84781619
6	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.79904122
7	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.79904122
8	replication fork processing (GO:0031297)	3.79358757
9	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.79265113
10	detection of chemical stimulus involved in sensory perception (GO:0050907)	3.73357424
11	DNA topological change (GO:0006265)	3.67051352
12	mitotic G2 DNA damage checkpoint (GO:0007095)	3.62892370
13	chromatin remodeling at centromere (GO:0031055)	3.59600323
14	mitotic G2/M transition checkpoint (GO:0044818)	3.58984182
15	regulation of hexokinase activity (GO:1903299)	3.57015988
16	regulation of glucokinase activity (GO:0033131)	3.57015988
17	metaphase plate congression (GO:0051310)	3.55457557
18	regulation of acyl-CoA biosynthetic process (GO:0050812)	3.53295560
19	response to insecticide (GO:0017085)	3.48862383
20	CENP-A containing nucleosome assembly (GO:0034080)	3.47597661
21	aldehyde catabolic process (GO:0046185)	3.47028680
22	DNA ligation (GO:0006266)	3.43124234
23	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.40103302
24	microtubule depolymerization (GO:0007019)	3.37167391
25	proteasome assembly (GO:0043248)	3.32763643
26	peptidyl-histidine modification (GO:0018202)	3.30629976
27	sister chromatid segregation (GO:0000819)	3.29983027
28	cytochrome complex assembly (GO:0017004)	3.29308823
29	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.27976158
30	oxidative phosphorylation (GO:0006119)	3.22846211
31	regulation of sulfur metabolic process (GO:0042762)	3.22814269
32	resolution of meiotic recombination intermediates (GO:0000712)	3.22537679
33	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.20964379
34	termination of RNA polymerase I transcription (GO:0006363)	3.18188173
35	respiratory chain complex IV assembly (GO:0008535)	3.18136041
36	non-recombinational repair (GO:0000726)	3.17031399
37	double-strand break repair via nonhomologous end joining (GO:0006303)	3.17031399
38	mitotic sister chromatid segregation (GO:0000070)	3.16167843
39	DNA replication checkpoint (GO:0000076)	3.12649317
40	regulation of coenzyme metabolic process (GO:0051196)	3.09323285
41	regulation of cofactor metabolic process (GO:0051193)	3.09323285
42	rRNA catabolic process (GO:0016075)	3.07619087
43	centriole assembly (GO:0098534)	3.06206612
44	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.05229321
45	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.05229321
46	isotype switching (GO:0045190)	3.05229321
47	chaperone-mediated protein complex assembly (GO:0051131)	3.04648526
48	transcription elongation from RNA polymerase I promoter (GO:0006362)	3.04603640
49	protein localization to kinetochore (GO:0034501)	3.02036366
50	double-strand break repair via homologous recombination (GO:0000724)	2.97029961
51	recombinational repair (GO:0000725)	2.96265178
52	kynurenine metabolic process (GO:0070189)	2.94990041
53	somatic diversification of immunoglobulins (GO:0016445)	2.94524800
54	microtubule anchoring (GO:0034453)	2.93870209
55	attachment of spindle microtubules to kinetochore (GO:0008608)	2.93774938
56	indolalkylamine metabolic process (GO:0006586)	2.93695859
57	DNA double-strand break processing (GO:0000729)	2.92328109
58	mitotic spindle checkpoint (GO:0071174)	2.91466804
59	histone exchange (GO:0043486)	2.90160370
60	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.89894133
61	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.89233166
62	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.84318873
63	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.83255890
64	spindle checkpoint (GO:0031577)	2.82614385
65	postreplication repair (GO:0006301)	2.82150375
66	positive regulation of histone H3-K4 methylation (GO:0051571)	2.81616111
67	DNA replication initiation (GO:0006270)	2.80489066
68	rRNA methylation (GO:0031167)	2.78829020
69	nuclear pore complex assembly (GO:0051292)	2.78243266
70	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.77159822
71	mitotic recombination (GO:0006312)	2.75874720
72	regulation of exit from mitosis (GO:0007096)	2.74389667
73	dopamine biosynthetic process (GO:0042416)	2.74126852
74	histone-serine phosphorylation (GO:0035404)	2.72259134
75	translesion synthesis (GO:0019985)	2.67948316
76	DNA replication-independent nucleosome assembly (GO:0006336)	2.67641990
77	DNA replication-independent nucleosome organization (GO:0034724)	2.67641990
78	telomere maintenance via semi-conservative replication (GO:0032201)	2.66631090
79	centrosome organization (GO:0051297)	2.65232266
80	mitotic sister chromatid cohesion (GO:0007064)	2.63403272
81	establishment of chromosome localization (GO:0051303)	2.62284386
82	mitotic nuclear envelope disassembly (GO:0007077)	2.62122448
83	viral mRNA export from host cell nucleus (GO:0046784)	2.61650124
84	indole-containing compound catabolic process (GO:0042436)	2.61259882
85	indolalkylamine catabolic process (GO:0046218)	2.61259882
86	tryptophan catabolic process (GO:0006569)	2.61259882
87	sister chromatid cohesion (GO:0007062)	2.60610156
88	negative regulation of DNA recombination (GO:0045910)	2.59295563
89	neural tube formation (GO:0001841)	2.58528323
90	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.58318477
91	synapsis (GO:0007129)	2.57850889
92	protein K11-linked deubiquitination (GO:0035871)	2.57514200
93	preassembly of GPI anchor in ER membrane (GO:0016254)	2.57427007
94	transcription initiation from RNA polymerase I promoter (GO:0006361)	2.55254578
95	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.55247273
96	sensory perception of chemical stimulus (GO:0007606)	2.55158073
97	pore complex assembly (GO:0046931)	2.55017359
98	prenylation (GO:0097354)	2.54246795
99	protein prenylation (GO:0018342)	2.54246795
100	tryptophan metabolic process (GO:0006568)	2.53213673

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.16759142
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.20351180
3	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.85463935
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.40251398
5	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	3.30865627
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.10653831
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.64705202
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.60304516
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.55881543
10	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.55648771
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.52448297
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.44829458
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.42417121
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.40659886
15	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.32056411
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.28236050
17	VDR_22108803_ChIP-Seq_LS180_Human	2.25162818
18	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.24014435
19	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.22508688
20	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.14988047
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.11942148
22	EWS_26573619_Chip-Seq_HEK293_Human	2.05804953
23	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.03771851
24	VDR_23849224_ChIP-Seq_CD4+_Human	2.00719074
25	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.95107862
26	FUS_26573619_Chip-Seq_HEK293_Human	1.91042226
27	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.90030971
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.88963008
29	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.86026304
30	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.84471007
31	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.81963431
32	IGF1R_20145208_ChIP-Seq_DFB_Human	1.81287625
33	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.77180831
34	TAF15_26573619_Chip-Seq_HEK293_Human	1.75090856
35	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.69225873
36	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.67580888
37	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.56363181
38	DCP1A_22483619_ChIP-Seq_HELA_Human	1.53118590
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.51236466
40	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.51128897
41	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.45705316
42	GABP_19822575_ChIP-Seq_HepG2_Human	1.44857914
43	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.40255520
44	AR_21909140_ChIP-Seq_LNCAP_Human	1.37097627
45	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.36990301
46	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.34051888
47	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.31787221
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.31410018
49	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.31146762
50	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.31045107
51	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.29825877
52	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.28338680
53	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.28104182
54	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.27079307
55	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.27001664
56	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.26390023
57	ER_23166858_ChIP-Seq_MCF-7_Human	1.23136871
58	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.20555857
59	P300_19829295_ChIP-Seq_ESCs_Human	1.20051184
60	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.19130074
61	CBP_20019798_ChIP-Seq_JUKART_Human	1.18370768
62	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.18370768
63	TTF2_22483619_ChIP-Seq_HELA_Human	1.17763182
64	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.17420840
65	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.16491976
66	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.14669297
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13347721
68	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.12640178
69	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.12408773
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10151138
71	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.09634185
72	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.08771553
73	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.07922399
74	IRF1_19129219_ChIP-ChIP_H3396_Human	1.07906147
75	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.07639041
76	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05962392
77	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.05202898
78	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.01557316
79	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.00728920
80	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.00587708
81	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.00168379
82	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.00038840
83	SOX2_19829295_ChIP-Seq_ESCs_Human	0.97734912
84	NANOG_19829295_ChIP-Seq_ESCs_Human	0.97734912
85	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.97035202
86	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.95466622
87	CBP_21632823_ChIP-Seq_H3396_Human	0.94606927
88	AR_20517297_ChIP-Seq_VCAP_Human	0.93386608
89	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.92648015
90	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92350479
91	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.92115080
92	TP53_22573176_ChIP-Seq_HFKS_Human	0.90378739
93	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.89640225
94	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.89576147
95	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.87815313
96	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.87307743
97	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.86734230
98	PHF8_20622853_ChIP-Seq_HELA_Human	0.85227220
99	STAT3_23295773_ChIP-Seq_U87_Human	0.84604395
100	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.84383184

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	4.49738300
2	MP0010094_abnormal_chromosome_stability	4.26263439
3	MP0008057_abnormal_DNA_replication	3.84983197
4	MP0009697_abnormal_copulation	3.24184353
5	MP0008058_abnormal_DNA_repair	3.06151537
6	MP0005360_urolithiasis	2.77613555
7	MP0000569_abnormal_digit_pigmentation	2.75072517
8	MP0004957_abnormal_blastocyst_morpholog	2.32939041
9	MP0004133_heterotaxia	2.25274842
10	MP0008995_early_reproductive_senescence	2.23244171
11	MP0006292_abnormal_olfactory_placode	2.19591971
12	MP0006072_abnormal_retinal_apoptosis	2.17661393
13	MP0004043_abnormal_pH_regulation	2.14625291
14	MP0003111_abnormal_nucleus_morphology	2.09653225
15	MP0003693_abnormal_embryo_hatching	2.05859088
16	MP0003786_premature_aging	2.00836068
17	MP0003718_maternal_effect	1.93248014
18	MP0008004_abnormal_stomach_pH	1.92228021
19	MP0003567_abnormal_fetal_cardiomyocyte	1.89756445
20	MP0008007_abnormal_cellular_replicative	1.81846451
21	MP0006036_abnormal_mitochondrial_physio	1.81779579
22	MP0008932_abnormal_embryonic_tissue	1.77320810
23	MP0003315_abnormal_perineum_morphology	1.73720092
24	MP0003077_abnormal_cell_cycle	1.70902425
25	MP0004264_abnormal_extraembryonic_tissu	1.69485613
26	MP0003385_abnormal_body_wall	1.65858217
27	MP0001764_abnormal_homeostasis	1.63242781
28	MP0003646_muscle_fatigue	1.61068220
29	MP0000383_abnormal_hair_follicle	1.57363366
30	MP0000372_irregular_coat_pigmentation	1.57213095
31	MP0001293_anophthalmia	1.54939070
32	MP0005248_abnormal_Harderian_gland	1.43551603
33	MP0005451_abnormal_body_composition	1.42559715
34	MP0005187_abnormal_penis_morphology	1.39800311
35	MP0000647_abnormal_sebaceous_gland	1.38908976
36	MP0005551_abnormal_eye_electrophysiolog	1.37351285
37	MP0005084_abnormal_gallbladder_morpholo	1.37067153
38	MP0002938_white_spotting	1.36935600
39	MP0005174_abnormal_tail_pigmentation	1.35865622
40	MP0005499_abnormal_olfactory_system	1.33446098
41	MP0005394_taste/olfaction_phenotype	1.33446098
42	MP0001529_abnormal_vocalization	1.33408214
43	MP0000516_abnormal_urinary_system	1.32563753
44	MP0005367_renal/urinary_system_phenotyp	1.32563753
45	MP0001929_abnormal_gametogenesis	1.30534172
46	MP0002928_abnormal_bile_duct	1.28373867
47	MP0004215_abnormal_myocardial_fiber	1.27874794
48	MP0000427_abnormal_hair_cycle	1.27836956
49	MP0001873_stomach_inflammation	1.27289807
50	MP0008877_abnormal_DNA_methylation	1.25747086
51	MP0005253_abnormal_eye_physiology	1.20999658
52	MP0003656_abnormal_erythrocyte_physiolo	1.19919442
53	MP0002233_abnormal_nose_morphology	1.19452869
54	MP0001697_abnormal_embryo_size	1.18026237
55	MP0003937_abnormal_limbs/digits/tail_de	1.17573556
56	MP0002139_abnormal_hepatobiliary_system	1.16034404
57	MP0008789_abnormal_olfactory_epithelium	1.15403728
58	MP0003943_abnormal_hepatobiliary_system	1.14281284
59	MP0002234_abnormal_pharynx_morphology	1.12912015
60	MP0001188_hyperpigmentation	1.08802456
61	MP0006035_abnormal_mitochondrial_morpho	1.06948279
62	MP0005646_abnormal_pituitary_gland	1.04053668
63	MP0002736_abnormal_nociception_after	1.03159894
64	MP0005636_abnormal_mineral_homeostasis	1.01156073
65	MP0003890_abnormal_embryonic-extraembry	0.99971169
66	MP0005266_abnormal_metabolism	0.98940596
67	MP0003252_abnormal_bile_duct	0.98279287
68	MP0010678_abnormal_skin_adnexa	0.97390158
69	MP0005171_absent_coat_pigmentation	0.94174627
70	MP0005380_embryogenesis_phenotype	0.92068239
71	MP0001672_abnormal_embryogenesis/_devel	0.92068239
72	MP0002095_abnormal_skin_pigmentation	0.90314658
73	MP0002102_abnormal_ear_morphology	0.90072049
74	MP0002210_abnormal_sex_determination	0.90019034
75	MP0005397_hematopoietic_system_phenotyp	0.89960182
76	MP0001545_abnormal_hematopoietic_system	0.89960182
77	MP0001986_abnormal_taste_sensitivity	0.89054993
78	MP0000653_abnormal_sex_gland	0.87066551
79	MP0005410_abnormal_fertilization	0.86955581
80	MP0003806_abnormal_nucleotide_metabolis	0.85578377
81	MP0002084_abnormal_developmental_patter	0.85029460
82	MP0002088_abnormal_embryonic_growth/wei	0.84075718
83	MP0003984_embryonic_growth_retardation	0.80970766
84	MP0005395_other_phenotype	0.80219899
85	MP0003698_abnormal_male_reproductive	0.80189976
86	MP0001286_abnormal_eye_development	0.78969832
87	MP0001145_abnormal_male_reproductive	0.78355106
88	MP0005391_vision/eye_phenotype	0.78101413
89	MP0000358_abnormal_cell_content/	0.75672895
90	MP0004145_abnormal_muscle_electrophysio	0.74912658
91	MP0000313_abnormal_cell_death	0.74395928
92	MP0010030_abnormal_orbit_morphology	0.72903588
93	MP0008875_abnormal_xenobiotic_pharmacok	0.71842386
94	MP0008873_increased_physiological_sensi	0.71340487
95	MP0001486_abnormal_startle_reflex	0.70614562
96	MP0005376_homeostasis/metabolism_phenot	0.70578940
97	MP0002160_abnormal_reproductive_system	0.69813289
98	MP0002085_abnormal_embryonic_tissue	0.68941486
99	MP0006276_abnormal_autonomic_nervous	0.68114967
100	MP0003186_abnormal_redox_activity	0.67019877

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.77640027
2	Birth length less than 3rd percentile (HP:0003561)	3.71950096
3	Short tibia (HP:0005736)	3.67934112
4	Volvulus (HP:0002580)	3.38782139
5	B lymphocytopenia (HP:0010976)	3.37849862
6	True hermaphroditism (HP:0010459)	3.25078129
7	Long nose (HP:0003189)	3.19814747
8	Abnormality of midbrain morphology (HP:0002418)	3.07784346
9	Molar tooth sign on MRI (HP:0002419)	3.07784346
10	Nephronophthisis (HP:0000090)	3.05005768
11	Acute necrotizing encephalopathy (HP:0006965)	3.02891122
12	Abnormality of B cell number (HP:0010975)	3.02188724
13	Acute encephalopathy (HP:0006846)	3.00462861
14	Abnormality of chromosome stability (HP:0003220)	2.97588303
15	Pancreatic cysts (HP:0001737)	2.93673177
16	Medulloblastoma (HP:0002885)	2.87162051
17	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.77407731
18	Progressive inability to walk (HP:0002505)	2.72627379
19	Renal Fanconi syndrome (HP:0001994)	2.68714728
20	Supernumerary spleens (HP:0009799)	2.68693109
21	Hypoplastic pelvis (HP:0008839)	2.66849322
22	Pancreatic fibrosis (HP:0100732)	2.66304746
23	Abnormal mitochondria in muscle tissue (HP:0008316)	2.60047893
24	Increased CSF lactate (HP:0002490)	2.55711848
25	Increased hepatocellular lipid droplets (HP:0006565)	2.52788055
26	Short humerus (HP:0005792)	2.51925948
27	Lipid accumulation in hepatocytes (HP:0006561)	2.51446238
28	Chromsome breakage (HP:0040012)	2.48847673
29	Thrombocytosis (HP:0001894)	2.46839081
30	Sloping forehead (HP:0000340)	2.43790165
31	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.38313179
32	Progressive macrocephaly (HP:0004481)	2.37766312
33	Abnormality of the renal medulla (HP:0100957)	2.36317734
34	Autoimmune hemolytic anemia (HP:0001890)	2.36116979
35	Rhabdomyosarcoma (HP:0002859)	2.35964115
36	Glioma (HP:0009733)	2.35298458
37	Methylmalonic acidemia (HP:0002912)	2.34410967
38	Aplasia/hypoplasia of the humerus (HP:0006507)	2.31534814
39	3-Methylglutaconic aciduria (HP:0003535)	2.29268633
40	Tubulointerstitial nephritis (HP:0001970)	2.28451607
41	Abnormality of the preputium (HP:0100587)	2.26133259
42	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.26126049
43	Cerebellar dysplasia (HP:0007033)	2.25953389
44	Acute lymphatic leukemia (HP:0006721)	2.22966290
45	Meckel diverticulum (HP:0002245)	2.19711503
46	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.18965524
47	Medial flaring of the eyebrow (HP:0010747)	2.17302710
48	Congenital primary aphakia (HP:0007707)	2.17224991
49	Abnormality of the ileum (HP:0001549)	2.11408184
50	Hypothermia (HP:0002045)	2.11152450
51	Increased serum lactate (HP:0002151)	2.11051580
52	Neurodegeneration (HP:0002180)	2.10361022
53	Gait imbalance (HP:0002141)	2.08454652
54	Nephrogenic diabetes insipidus (HP:0009806)	2.08452929
55	Preaxial hand polydactyly (HP:0001177)	2.08333965
56	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.07423600
57	Mitochondrial inheritance (HP:0001427)	2.07026611
58	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.06222663
59	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.04681504
60	Hyperglycinemia (HP:0002154)	2.01675491
61	Vaginal atresia (HP:0000148)	2.01144026
62	Genital tract atresia (HP:0001827)	1.97836428
63	Abnormality of methionine metabolism (HP:0010901)	1.96550059
64	Prominent nasal bridge (HP:0000426)	1.95434251
65	Anal atresia (HP:0002023)	1.93644285
66	Curly hair (HP:0002212)	1.92377837
67	Limb dystonia (HP:0002451)	1.92210292
68	Dyskinesia (HP:0100660)	1.90990582
69	Periodontitis (HP:0000704)	1.90351705
70	Postaxial foot polydactyly (HP:0001830)	1.88523111
71	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.86407428
72	Triphalangeal thumb (HP:0001199)	1.86406723
73	Degeneration of anterior horn cells (HP:0002398)	1.85145324
74	Abnormality of the anterior horn cell (HP:0006802)	1.85145324
75	Cystic liver disease (HP:0006706)	1.85114825
76	Occipital encephalocele (HP:0002085)	1.84797949
77	Oculomotor apraxia (HP:0000657)	1.83968220
78	Posterior subcapsular cataract (HP:0007787)	1.83860142
79	Cerebral edema (HP:0002181)	1.83067813
80	Hypoplasia of the pons (HP:0012110)	1.81932694
81	Lactic acidosis (HP:0003128)	1.81820027
82	Aplastic anemia (HP:0001915)	1.81018701
83	Thyroid carcinoma (HP:0002890)	1.80602780
84	Poor coordination (HP:0002370)	1.79841740
85	Small intestinal stenosis (HP:0012848)	1.78656841
86	Duodenal stenosis (HP:0100867)	1.78656841
87	Median cleft lip (HP:0000161)	1.78450741
88	Bile duct proliferation (HP:0001408)	1.78117760
89	Abnormal biliary tract physiology (HP:0012439)	1.78117760
90	Abnormal lung lobation (HP:0002101)	1.77624113
91	Abnormality of the pons (HP:0007361)	1.76997748
92	Sclerocornea (HP:0000647)	1.76599634
93	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.75055415
94	Short 1st metacarpal (HP:0010034)	1.75055415
95	Abnormality of the carotid arteries (HP:0005344)	1.73551204
96	Oligodactyly (hands) (HP:0001180)	1.71487776
97	Abnormality of abdominal situs (HP:0011620)	1.70728971
98	Abdominal situs inversus (HP:0003363)	1.70728971
99	High anterior hairline (HP:0009890)	1.67954992
100	Aganglionic megacolon (HP:0002251)	1.66380809

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WEE1	4.32300536
2	BRSK2	4.26788044
3	PBK	4.21582316
4	PNCK	3.79621135
5	TNIK	3.16205163
6	MST4	2.80704858
7	TSSK6	2.34570594
8	TRIM28	2.34005725
9	CDC7	2.32080482
10	BMPR1B	2.18843617
11	WNK3	2.18698486
12	MKNK1	2.07625959
13	BUB1	1.99779236
14	NEK1	1.88179209
15	MAP3K12	1.87891794
16	PLK3	1.84301922
17	MKNK2	1.80087864
18	ZAK	1.74849661
19	ACVR1B	1.67894748
20	MAPK13	1.64330254
21	BRD4	1.64124573
22	NUAK1	1.63248223
23	SRPK1	1.59450315
24	BRSK1	1.55612954
25	CCNB1	1.52263106
26	MAPKAPK5	1.50137744
27	PLK4	1.47128392
28	TTK	1.44213594
29	MAP3K4	1.41532628
30	PDK2	1.37039043
31	MAP4K2	1.35910509
32	PKN1	1.29517001
33	FRK	1.28273884
34	TGFBR1	1.23800421
35	EIF2AK1	1.12614037
36	PLK1	1.08766854
37	MAP2K7	1.06422341
38	NEK9	1.05043882
39	NEK2	1.04716686
40	ATR	1.04698635
41	ERBB3	1.03615621
42	WNK4	1.02535171
43	EIF2AK3	0.92845936
44	NLK	0.92037167
45	VRK1	0.91439078
46	STK16	0.87802656
47	CHEK2	0.84671041
48	NME1	0.84126706
49	CASK	0.83328070
50	MAP3K10	0.78212147
51	FGFR1	0.76031714
52	STK39	0.74451937
53	ATM	0.74273337
54	BCKDK	0.74091511
55	MARK3	0.72655755
56	DYRK3	0.70024076
57	CDK8	0.66176742
58	GRK1	0.63677519
59	STK10	0.61720628
60	STK4	0.61642333
61	MST1R	0.61352617
62	AURKB	0.60763650
63	PRKCQ	0.60160601
64	ERBB4	0.58602197
65	TAOK3	0.57418469
66	DAPK1	0.56075597
67	BCR	0.55459187
68	SCYL2	0.51784585
69	YES1	0.50870504
70	NME2	0.50136556
71	CHEK1	0.49908354
72	CAMKK2	0.47109386
73	MAPKAPK3	0.46637160
74	MYLK	0.45149585
75	TNK2	0.44244495
76	STK3	0.43301223
77	CSNK2A2	0.42793982
78	LIMK1	0.42553595
79	PIK3CG	0.42025741
80	TEC	0.41794746
81	RAF1	0.41547831
82	EIF2AK2	0.36540435
83	RPS6KA4	0.35789675
84	FLT3	0.35737047
85	PRKCG	0.34662359
86	RPS6KA5	0.34381074
87	PASK	0.31308497
88	CDK1	0.30724517
89	CSNK2A1	0.30429924
90	CDK7	0.27333807
91	PIM2	0.26516841
92	TRPM7	0.25396831
93	MAP3K8	0.23727922
94	ROCK1	0.22704145
95	ERBB2	0.20769286
96	CDK2	0.20258633
97	ALK	0.18848488
98	CSNK1A1L	0.17609511
99	INSRR	0.17445964
100	PRKDC	0.17103576

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Olfactory transduction_Homo sapiens_hsa04740	3.79465672
2	Non-homologous end-joining_Homo sapiens_hsa03450	3.50630882
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.99742815
4	Homologous recombination_Homo sapiens_hsa03440	2.73735852
5	Basal transcription factors_Homo sapiens_hsa03022	2.69301491
6	Propanoate metabolism_Homo sapiens_hsa00640	2.66651853
7	Proteasome_Homo sapiens_hsa03050	2.50229166
8	DNA replication_Homo sapiens_hsa03030	2.49525922
9	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.48376683
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.46843654
11	Fanconi anemia pathway_Homo sapiens_hsa03460	2.42653949
12	Mismatch repair_Homo sapiens_hsa03430	2.40856376
13	Protein export_Homo sapiens_hsa03060	2.20245898
14	Base excision repair_Homo sapiens_hsa03410	2.14269426
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.11394975
16	RNA polymerase_Homo sapiens_hsa03020	2.09346729
17	Butanoate metabolism_Homo sapiens_hsa00650	2.07154281
18	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.06956899
19	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.93672510
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.84869028
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.82150000
22	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.81290796
23	Cell cycle_Homo sapiens_hsa04110	1.75314707
24	Parkinsons disease_Homo sapiens_hsa05012	1.74470367
25	RNA transport_Homo sapiens_hsa03013	1.72270440
26	RNA degradation_Homo sapiens_hsa03018	1.65022942
27	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.54017807
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.51194644
29	Oxidative phosphorylation_Homo sapiens_hsa00190	1.50280625
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.45159940
31	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.44500109
32	Pyruvate metabolism_Homo sapiens_hsa00620	1.41843870
33	Phototransduction_Homo sapiens_hsa04744	1.39470413
34	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.31316747
35	Spliceosome_Homo sapiens_hsa03040	1.29000004
36	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.25306146
37	Purine metabolism_Homo sapiens_hsa00230	1.23286499
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.17793650
39	Huntingtons disease_Homo sapiens_hsa05016	1.16949299
40	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.11196578
41	Steroid biosynthesis_Homo sapiens_hsa00100	1.08415907
42	One carbon pool by folate_Homo sapiens_hsa00670	1.06842006
43	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.03024180
44	Glutathione metabolism_Homo sapiens_hsa00480	0.99303198
45	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.98609844
46	Tyrosine metabolism_Homo sapiens_hsa00350	0.96122390
47	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.95074608
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.94891907
49	Tryptophan metabolism_Homo sapiens_hsa00380	0.93224509
50	p53 signaling pathway_Homo sapiens_hsa04115	0.92455518
51	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.91827115
52	Oocyte meiosis_Homo sapiens_hsa04114	0.91135145
53	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.87759267
54	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.85792695
55	Regulation of autophagy_Homo sapiens_hsa04140	0.78611397
56	Alzheimers disease_Homo sapiens_hsa05010	0.77556198
57	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.73474935
58	Selenocompound metabolism_Homo sapiens_hsa00450	0.71650701
59	Metabolic pathways_Homo sapiens_hsa01100	0.67147624
60	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.63541387
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.62537361
62	Lysine degradation_Homo sapiens_hsa00310	0.61141375
63	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.59015209
64	Peroxisome_Homo sapiens_hsa04146	0.57054225
65	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.55337545
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.53594783
67	Carbon metabolism_Homo sapiens_hsa01200	0.53129907
68	Nicotine addiction_Homo sapiens_hsa05033	0.53064153
69	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.51504319
70	Asthma_Homo sapiens_hsa05310	0.50071047
71	Linoleic acid metabolism_Homo sapiens_hsa00591	0.50050535
72	Phenylalanine metabolism_Homo sapiens_hsa00360	0.49584121
73	beta-Alanine metabolism_Homo sapiens_hsa00410	0.43758770
74	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.39153549
75	Taste transduction_Homo sapiens_hsa04742	0.38737943
76	Retinol metabolism_Homo sapiens_hsa00830	0.37668825
77	Arginine and proline metabolism_Homo sapiens_hsa00330	0.35571064
78	Ribosome_Homo sapiens_hsa03010	0.35441140
79	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.35259059
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.33752268
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.32393982
82	Ether lipid metabolism_Homo sapiens_hsa00565	0.30479877
83	Nitrogen metabolism_Homo sapiens_hsa00910	0.29630566
84	Primary immunodeficiency_Homo sapiens_hsa05340	0.27884707
85	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.27100640
86	Chemical carcinogenesis_Homo sapiens_hsa05204	0.25581811
87	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.25133488
88	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.24953340
89	Caffeine metabolism_Homo sapiens_hsa00232	0.24853493
90	Wnt signaling pathway_Homo sapiens_hsa04310	0.24795119
91	mRNA surveillance pathway_Homo sapiens_hsa03015	0.24112517
92	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.21676309
93	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.20500567
94	Renin-angiotensin system_Homo sapiens_hsa04614	0.20334479
95	Basal cell carcinoma_Homo sapiens_hsa05217	0.19529350
96	Fatty acid metabolism_Homo sapiens_hsa01212	0.18689459
97	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.16736226
98	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.16607283
99	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.15812115
100	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.12823188

OR51B8P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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