OR51C1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adaptation of signaling pathway (GO:0023058)9.07038094
2positive regulation of chemokine secretion (GO:0090197)8.74823276
3regulation of chemokine secretion (GO:0090196)7.56373971
4negative regulation of protein localization to cell surface (GO:2000009)7.31635109
5negative regulation of sodium ion transport (GO:0010766)7.11641889
6long-chain fatty acid biosynthetic process (GO:0042759)6.80591698
7positive regulation of keratinocyte differentiation (GO:0045618)6.54082050
8positive regulation of digestive system process (GO:0060456)6.50948643
9toxin transport (GO:1901998)6.48614623
10negative regulation of systemic arterial blood pressure (GO:0003085)6.45158877
11regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)6.35233312
12regulation of tight junction assembly (GO:2000810)6.34819883
13linoleic acid metabolic process (GO:0043651)6.23908039
14retinal metabolic process (GO:0042574)5.84685710
15plasma membrane repair (GO:0001778)5.79540840
16positive regulation of blood pressure (GO:0045777)5.66455195
17regulation of endocrine process (GO:0044060)5.63585202
18sequestering of extracellular ligand from receptor (GO:0035581)5.53427828
19mature B cell differentiation (GO:0002335)5.46956437
20cellular response to fatty acid (GO:0071398)5.42635490
21positive regulation of macrophage derived foam cell differentiation (GO:0010744)5.23966505
22positive regulation of T cell cytokine production (GO:0002726)5.17620648
23negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.14397447
24lipoxygenase pathway (GO:0019372)5.07002824
25regulation of fatty acid oxidation (GO:0046320)5.03609404
26regulation of memory T cell differentiation (GO:0043380)4.99264894
27intestinal epithelial cell development (GO:0060576)4.88543414
28regulation of regulatory T cell differentiation (GO:0045589)4.88496404
29interkinetic nuclear migration (GO:0022027)4.86816409
30negative regulation of fatty acid transport (GO:2000192)4.81089061
31negative regulation of complement activation (GO:0045916)4.79881083
32endothelial cell chemotaxis (GO:0035767)4.57293633
33amine catabolic process (GO:0009310)4.49371329
34cellular biogenic amine catabolic process (GO:0042402)4.49371329
35pre-miRNA processing (GO:0031054)4.45951232
36negative regulation of potassium ion transmembrane transport (GO:1901380)4.43202511
37quaternary ammonium group transport (GO:0015697)4.26989010
38lung vasculature development (GO:0060426)4.25614570
39negative regulation of protein activation cascade (GO:2000258)4.25072985
40positive regulation of epidermal cell differentiation (GO:0045606)4.24345560
41regulation of keratinocyte differentiation (GO:0045616)4.14359757
42carnitine transmembrane transport (GO:1902603)4.14184431
43mannose metabolic process (GO:0006013)4.10485609
44negative regulation of fatty acid biosynthetic process (GO:0045717)4.09229054
45polyamine biosynthetic process (GO:0006596)4.09024040
46diterpenoid biosynthetic process (GO:0016102)3.96879509
47regulation of fatty acid beta-oxidation (GO:0031998)3.95421648
48homocysteine metabolic process (GO:0050667)3.89361395
49regulation of T cell cytokine production (GO:0002724)3.86094067
50import into cell (GO:0098657)3.84523851
51histone H3-K9 demethylation (GO:0033169)3.82079209
52organic cation transport (GO:0015695)3.79375261
53negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.78649528
54carnitine transport (GO:0015879)3.78298589
55amino-acid betaine transport (GO:0015838)3.78298589
56negative regulation of humoral immune response (GO:0002921)3.75261200
57GDP-mannose metabolic process (GO:0019673)3.70564834
58histone lysine demethylation (GO:0070076)3.70320706
59negative regulation of cAMP-mediated signaling (GO:0043951)3.64100366
60ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.63734377
61iron ion import (GO:0097286)3.63461599
62negative regulation of glial cell proliferation (GO:0060253)3.57445211
63monoubiquitinated protein deubiquitination (GO:0035520)3.53199310
64positive regulation of cellular amine metabolic process (GO:0033240)3.52154370
65response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.48719337
66positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.47272961
67positive regulation of fatty acid oxidation (GO:0046321)3.44013154
68histone demethylation (GO:0016577)3.42648864
69cellular response to hepatocyte growth factor stimulus (GO:0035729)3.35243861
70response to hepatocyte growth factor (GO:0035728)3.35243861
71phospholipid scrambling (GO:0017121)3.28495600
72detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.25854210
73steroid hormone mediated signaling pathway (GO:0043401)3.25434480
74positive regulation of transforming growth factor beta production (GO:0071636)3.24163871
75protein homotrimerization (GO:0070207)3.19736993
76activation of NF-kappaB-inducing kinase activity (GO:0007250)3.18527995
77lung epithelium development (GO:0060428)3.15459545
78protein dealkylation (GO:0008214)3.09810003
79protein demethylation (GO:0006482)3.09810003
80retinol metabolic process (GO:0042572)3.08612122
81regulation of protein localization to cell surface (GO:2000008)3.05052136
82cellular biogenic amine biosynthetic process (GO:0042401)3.04004829
83UDP-N-acetylglucosamine metabolic process (GO:0006047)2.98531465
84temperature homeostasis (GO:0001659)2.97064050
85negative regulation of fatty acid metabolic process (GO:0045922)2.95517154
86cellular sodium ion homeostasis (GO:0006883)2.93698903
87positive regulation of protein kinase C signaling (GO:0090037)2.93195989
88negative regulation of multicellular organism growth (GO:0040015)2.93113140
89positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.91663214
90extracellular negative regulation of signal transduction (GO:1900116)2.90601402
91extracellular regulation of signal transduction (GO:1900115)2.90601402
92benzene-containing compound metabolic process (GO:0042537)2.88291660
93response to fatty acid (GO:0070542)2.88121485
94positive regulation of cation channel activity (GO:2001259)2.86519927
95endocardial cushion development (GO:0003197)2.86025644
96glucocorticoid receptor signaling pathway (GO:0042921)2.85699490
97positive regulation of glycolytic process (GO:0045821)2.85335782
98amine biosynthetic process (GO:0009309)2.85038579
99positive regulation of fatty acid beta-oxidation (GO:0032000)2.84696083
100skin morphogenesis (GO:0043589)2.84174318

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.33526560
2ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse3.79350585
3STAT6_21828071_ChIP-Seq_BEAS2B_Human2.89405102
4AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.82996699
5ESR2_21235772_ChIP-Seq_MCF-7_Human2.71084713
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.68528179
7PIAS1_25552417_ChIP-Seq_VCAP_Human2.65184401
8FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.34931811
9P300_27058665_Chip-Seq_ZR-75-30cells_Human2.14988659
10TBL1_22424771_ChIP-Seq_293T_Human2.13596127
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.11948109
12E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human2.10789490
13RACK7_27058665_Chip-Seq_MCF-7_Human2.06145695
14FOXA1_26743006_Chip-Seq_LNCaP-abl_Human2.02406203
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.01945192
16ESR1_20079471_ChIP-ChIP_T-47D_Human1.97620854
17KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.97191848
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.96301005
19NFYA_21822215_ChIP-Seq_K562_Human1.94644178
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.94435505
21CBP_21632823_ChIP-Seq_H3396_Human1.90681177
22NFYB_21822215_ChIP-Seq_K562_Human1.89133074
23ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.89132087
24AR_21909140_ChIP-Seq_LNCAP_Human1.86918293
25AR_21572438_ChIP-Seq_LNCaP_Human1.86130812
26CREB1_26743006_Chip-Seq_LNCaP_Human1.85576592
27AHR_22903824_ChIP-Seq_MCF-7_Human1.82178608
28HNFA_21074721_ChIP-Seq_CACO-2_Human1.81746335
29CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.80329832
30NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.79870260
31ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.77339071
32FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.76617526
33KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.70586973
34CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.70319619
35GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.69152552
36PHF8_20622853_ChIP-Seq_HELA_Human1.67837499
37CTNNB1_20460455_ChIP-Seq_HCT116_Human1.66370994
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65360557
39GATA6_21074721_ChIP-Seq_CACO-2_Human1.63274914
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.63197719
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.62765110
42RUNX1_27514584_Chip-Seq_MCF-7_Human1.58834322
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58347932
44GATA6_25053715_ChIP-Seq_YYC3_Human1.57407397
45CHD1_26751641_Chip-Seq_LNCaP_Human1.55526873
46EOMES_21245162_ChIP-Seq_HESCs_Human1.48564699
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.47435285
48NFIB_24661679_ChIP-Seq_LUNG_Mouse1.46775965
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.42512630
50LXR_22158963_ChIP-Seq_LIVER_Mouse1.41654653
51FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37777930
52SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.37267236
53SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.37267236
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.35037573
55VDR_22108803_ChIP-Seq_LS180_Human1.34289391
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33751680
57FOXA2_19822575_ChIP-Seq_HepG2_Human1.32709454
58SA1_27219007_Chip-Seq_Bcells_Human1.32254993
59CTCF_27219007_Chip-Seq_Bcells_Human1.30610059
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27785437
61SOX2_27498859_Chip-Seq_STOMACH_Mouse1.23672104
62MAF_26560356_Chip-Seq_TH2_Human1.19883638
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.19258378
64CBP_20019798_ChIP-Seq_JUKART_Human1.17355605
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17355605
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16377624
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.16014434
68ETV1_20927104_ChIP-Seq_GIST48_Human1.15425643
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15057140
70MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14879550
71KDM2B_26808549_Chip-Seq_DND41_Human1.13167573
72RXR_22108803_ChIP-Seq_LS180_Human1.11730519
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.08668855
74MAF_26560356_Chip-Seq_TH1_Human1.08508135
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08447576
76DROSHA_22980978_ChIP-Seq_HELA_Human1.07997180
77RBPJ_21746931_ChIP-Seq_IB4_Human1.07292809
78FOXA1_25552417_ChIP-Seq_VCAP_Human1.07212665
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07033594
80KDM2B_26808549_Chip-Seq_K562_Human1.05659847
81KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05520711
82PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04900396
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03847562
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.01437349
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00766923
86TCF4_18268006_ChIP-ChIP_LS174T_Human1.00169104
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98256934
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98256934
89IRF1_19129219_ChIP-ChIP_H3396_Human0.97124577
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96282498
91STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.93446599
92IRF8_22096565_ChIP-ChIP_GC-B_Human0.93266412
93UBF1/2_26484160_Chip-Seq_HMECs_Human0.93065314
94SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91646057
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91630609
96CBX2_22325352_ChIP-Seq_293T-Rex_Human0.91430430
97OCT1_27270436_Chip-Seq_PROSTATE_Human0.91155261
98STAT1_20625510_ChIP-Seq_HELA_Human0.90711037
99GATA3_24758297_ChIP-Seq_MCF-7_Human0.90438994
100PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.90363006

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004510_myositis6.50824402
2MP0003011_delayed_dark_adaptation6.29551224
3MP0005167_abnormal_blood-brain_barrier5.05485129
4MP0008057_abnormal_DNA_replication4.50915282
5MP0002735_abnormal_chemical_nociception3.50829201
6MP0003045_fibrosis3.48606733
7MP0004858_abnormal_nervous_system3.36936158
8MP0001188_hyperpigmentation2.59300274
9MP0002822_catalepsy2.54575634
10MP0003705_abnormal_hypodermis_morpholog2.52926119
11MP0002877_abnormal_melanocyte_morpholog2.38063220
12MP0001756_abnormal_urination2.37850313
13MP0002653_abnormal_ependyma_morphology2.30778169
14MP0004947_skin_inflammation2.16670822
15MP0003136_yellow_coat_color2.16528293
16MP0005670_abnormal_white_adipose2.10286344
17MP0000685_abnormal_immune_system2.07900128
18MP0001666_abnormal_nutrient_absorption2.07700934
19MP0005085_abnormal_gallbladder_physiolo2.01438439
20MP0009840_abnormal_foam_cell1.98503967
21MP0001542_abnormal_bone_strength1.86592913
22MP0003646_muscle_fatigue1.76466221
23MP0010368_abnormal_lymphatic_system1.75626672
24MP0005310_abnormal_salivary_gland1.70373353
25MP0000383_abnormal_hair_follicle1.68754235
26MP0001765_abnormal_ion_homeostasis1.65586374
27MP0002138_abnormal_hepatobiliary_system1.65031142
28MP0004019_abnormal_vitamin_homeostasis1.63133299
29MP0001501_abnormal_sleep_pattern1.62145589
30MP0005595_abnormal_vascular_smooth1.61074984
31MP0002168_other_aberrant_phenotype1.58793139
32MP0004883_abnormal_blood_vessel1.52026813
33MP0002234_abnormal_pharynx_morphology1.48370234
34MP0002933_joint_inflammation1.40752364
35MP0000230_abnormal_systemic_arterial1.35578162
36MP0005395_other_phenotype1.28532981
37MP0005332_abnormal_amino_acid1.27342044
38MP0003879_abnormal_hair_cell1.22711161
39MP0001968_abnormal_touch/_nociception1.21038349
40MP0000249_abnormal_blood_vessel1.17896207
41MP0001346_abnormal_lacrimal_gland1.16079576
42MP0001879_abnormal_lymphatic_vessel1.14770780
43MP0005620_abnormal_muscle_contractility1.13008017
44MP0005248_abnormal_Harderian_gland1.07440053
45MP0009643_abnormal_urine_homeostasis1.07407731
46MP0003828_pulmonary_edema1.05222858
47MP0004043_abnormal_pH_regulation1.05005161
48MP0005220_abnormal_exocrine_pancreas1.03575926
49MP0000371_diluted_coat_color1.02484084
50MP0008961_abnormal_basal_metabolism1.02083956
51MP0010678_abnormal_skin_adnexa1.00844951
52MP0002136_abnormal_kidney_physiology0.99315058
53MP0002733_abnormal_thermal_nociception0.97651469
54MP0003718_maternal_effect0.97499255
55MP0000569_abnormal_digit_pigmentation0.96859167
56MP0000566_synostosis0.96214769
57MP0002928_abnormal_bile_duct0.94807308
58MP0005666_abnormal_adipose_tissue0.91049460
59MP0002736_abnormal_nociception_after0.90850232
60MP0005164_abnormal_response_to0.89153542
61MP0001727_abnormal_embryo_implantation0.86338230
62MP0005174_abnormal_tail_pigmentation0.86215749
63MP0000538_abnormal_urinary_bladder0.82061471
64MP0004185_abnormal_adipocyte_glucose0.82041011
65MP0005551_abnormal_eye_electrophysiolog0.80386094
66MP0000367_abnormal_coat/_hair0.79598502
67MP0002405_respiratory_system_inflammati0.79303117
68MP0001986_abnormal_taste_sensitivity0.78868858
69MP0002693_abnormal_pancreas_physiology0.75115126
70MP0002075_abnormal_coat/hair_pigmentati0.70553901
71MP0002118_abnormal_lipid_homeostasis0.70506544
72MP0003091_abnormal_cell_migration0.67712702
73MP0002972_abnormal_cardiac_muscle0.66326618
74MP0005253_abnormal_eye_physiology0.66196612
75MP0001664_abnormal_digestion0.65673854
76MP0005408_hypopigmentation0.65195367
77MP0002909_abnormal_adrenal_gland0.64694095
78MP0001731_abnormal_postnatal_growth0.63139324
79MP0010155_abnormal_intestine_physiology0.61911815
80MP0001970_abnormal_pain_threshold0.61196493
81MP0005409_darkened_coat_color0.60171829
82MP0004885_abnormal_endolymph0.59906673
83MP0001485_abnormal_pinna_reflex0.59876644
84MP0001186_pigmentation_phenotype0.59330162
85MP0001502_abnormal_circadian_rhythm0.59244036
86MP0001299_abnormal_eye_distance/0.58733758
87MP0005621_abnormal_cell_physiology0.58700679
88MP0004264_abnormal_extraembryonic_tissu0.58339011
89MP0003953_abnormal_hormone_level0.58107549
90MP0005646_abnormal_pituitary_gland0.56868620
91MP0002078_abnormal_glucose_homeostasis0.55317450
92MP0004036_abnormal_muscle_relaxation0.55233733
93MP0005636_abnormal_mineral_homeostasis0.54692595
94MP0010329_abnormal_lipoprotein_level0.52746121
95MP0003221_abnormal_cardiomyocyte_apopto0.52177263
96MP0004085_abnormal_heartbeat0.51036195
97MP0003195_calcinosis0.50385271
98MP0000613_abnormal_salivary_gland0.49028598
99MP0000749_muscle_degeneration0.48122801
100MP0002098_abnormal_vibrissa_morphology0.47802378

Predicted human phenotypes

RankGene SetZ-score
1Hypoplasia of the pons (HP:0012110)5.84808567
2Nuclear cataract (HP:0100018)5.59736759
3Papilledema (HP:0001085)5.58735070
4Abnormality of the pons (HP:0007361)5.50551226
5Genetic anticipation (HP:0003743)5.44762550
6Gaze-evoked nystagmus (HP:0000640)5.35752370
7Progressive cerebellar ataxia (HP:0002073)4.75773857
8Dysmetric saccades (HP:0000641)4.35204313
9Neoplasm of the tracheobronchial system (HP:0100552)4.29879369
10Abnormality of homocysteine metabolism (HP:0010919)3.98416962
11Homocystinuria (HP:0002156)3.98416962
12Stomach cancer (HP:0012126)3.98414758
13Cerebellar dysplasia (HP:0007033)3.50862761
14Dysdiadochokinesis (HP:0002075)3.50825678
15Prostate neoplasm (HP:0100787)3.48901532
16Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.41512915
17Impaired smooth pursuit (HP:0007772)3.36630538
18Myokymia (HP:0002411)3.31149220
19Biconcave vertebral bodies (HP:0004586)3.24317944
20Clumsiness (HP:0002312)3.22098661
21Generalized hypopigmentation of hair (HP:0011358)3.21467950
22Lip pit (HP:0100267)3.19334574
23Autoimmune thrombocytopenia (HP:0001973)3.06439810
24Abnormality of proline metabolism (HP:0010907)3.06266860
25Hydroxyprolinuria (HP:0003080)3.06266860
26Amelogenesis imperfecta (HP:0000705)3.02806910
27Hypoalbuminemia (HP:0003073)2.95300367
28Abnormal albumin level (HP:0012116)2.95300367
29Tubular atrophy (HP:0000092)2.86066240
30Short nail (HP:0001799)2.85181552
31Confusion (HP:0001289)2.85127546
32Reduced antithrombin III activity (HP:0001976)2.77249962
33Decreased circulating renin level (HP:0003351)2.71122227
34Tented upper lip vermilion (HP:0010804)2.67978341
35Mediastinal lymphadenopathy (HP:0100721)2.64026282
36Limb ataxia (HP:0002070)2.63934529
37Stroke (HP:0001297)2.61980749
38Severe Myopia (HP:0011003)2.56828607
39Zonular cataract (HP:0010920)2.54598536
40Abnormality of ocular smooth pursuit (HP:0000617)2.54415439
41Supernumerary bones of the axial skeleton (HP:0009144)2.47579038
42Severe muscular hypotonia (HP:0006829)2.43490620
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.43071755
44Impaired vibratory sensation (HP:0002495)2.42125415
45Papillary thyroid carcinoma (HP:0002895)2.36140045
46Supernumerary ribs (HP:0005815)2.34879602
47Depressed nasal tip (HP:0000437)2.30458672
48Hyperventilation (HP:0002883)2.29964251
49Polar cataract (HP:0010696)2.29469623
50Broad-based gait (HP:0002136)2.28497734
51Aplasia/Hypoplasia of the tibia (HP:0005772)2.28415363
52Cone-rod dystrophy (HP:0000548)2.25801414
53Goiter (HP:0000853)2.23808631
54Rhabdomyosarcoma (HP:0002859)2.23733481
55Neoplasm of the lung (HP:0100526)2.23402646
56Broad face (HP:0000283)2.23065707
57Submucous cleft hard palate (HP:0000176)2.22616520
58Nonimmune hydrops fetalis (HP:0001790)2.21188578
59Pulmonary artery stenosis (HP:0004415)2.17368467
60Abnormality of the nasal septum (HP:0000419)2.17225607
61Proximal tubulopathy (HP:0000114)2.11795992
62Neoplasm of striated muscle (HP:0009728)2.11594235
63Retinal detachment (HP:0000541)2.10624211
64Type II lissencephaly (HP:0007260)2.07505743
65Protruding tongue (HP:0010808)2.07312650
66Onion bulb formation (HP:0003383)2.06244764
67Increased cerebral lipofuscin (HP:0011813)2.05896471
68Abnormal drinking behavior (HP:0030082)2.03643003
69Polydipsia (HP:0001959)2.03643003
70Pulmonary infiltrates (HP:0002113)2.03413883
71Segmental peripheral demyelination/remyelination (HP:0003481)2.00219661
72Febrile seizures (HP:0002373)1.99028138
73Abnormality of the distal phalanges of the toes (HP:0010182)1.99014237
74Flat cornea (HP:0007720)1.98514171
75Prolonged partial thromboplastin time (HP:0003645)1.97193968
76Aortic aneurysm (HP:0004942)1.96682474
77Osteolytic defects of the phalanges of the hand (HP:0009771)1.96554855
78Osteolytic defects of the hand bones (HP:0009699)1.96554855
79Abnormality of renin-angiotensin system (HP:0000847)1.94459682
80Metabolic alkalosis (HP:0200114)1.94282845
81Obstructive sleep apnea (HP:0002870)1.93044593
82Disproportionate tall stature (HP:0001519)1.92580659
83IgA deficiency (HP:0002720)1.89508462
84Abnormality of the fingertips (HP:0001211)1.88052221
85Large for gestational age (HP:0001520)1.87061349
86Macular degeneration (HP:0000608)1.85530689
87Urinary bladder sphincter dysfunction (HP:0002839)1.84929285
88Fair hair (HP:0002286)1.83652775
89Type I transferrin isoform profile (HP:0003642)1.83608226
90Abnormality of cochlea (HP:0000375)1.83535336
91Neoplasm of the respiratory system (HP:0100606)1.83395832
92Medulloblastoma (HP:0002885)1.83115804
93Tachypnea (HP:0002789)1.82022248
94Sensorimotor neuropathy (HP:0007141)1.81942259
95Abnormality of the intrinsic pathway (HP:0010989)1.79724790
96Intestinal fistula (HP:0100819)1.78877511
97Abnormality of saccadic eye movements (HP:0000570)1.78373398
98Alveolar cell carcinoma (HP:0006519)1.76273468
99Epileptic encephalopathy (HP:0200134)1.75907922
100Popliteal pterygium (HP:0009756)1.75530474

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT34.76735937
2TRIB34.38777596
3EEF2K3.37333963
4ERN13.34685189
5FRK3.27661383
6SGK23.06138109
7PKN23.03860015
8MAP2K62.97806160
9STK38L2.88233789
10TAOK12.70599414
11SGK2232.63540362
12SGK4942.63540362
13YES12.39224358
14SGK32.08388296
15MAPKAPK32.03803294
16PRKD32.03137689
17WNK12.02386941
18MAP3K112.01546791
19TAOK31.83901975
20TAOK21.83119325
21MAP3K31.80099409
22MKNK21.77882166
23PTK61.73197747
24MAP3K131.70206646
25STK381.67530818
26DAPK21.58597087
27LATS11.58555759
28MARK21.54157249
29CDK121.40764391
30PRKAA21.36749239
31NLK1.32920993
32DMPK1.32391692
33MTOR1.29642705
34EPHA31.27791008
35TNK21.26269017
36TRPM71.22469633
37BTK1.16664608
38CHUK1.12815963
39MAP3K71.07799545
40MAP2K31.05240745
41ITK1.05211771
42MAPK150.97968466
43PTK20.95789561
44CDC42BPA0.95708608
45STK240.95065447
46NEK60.93450459
47SGK10.90079297
48ERBB20.87211801
49TNIK0.83864029
50ACVR1B0.83245814
51HIPK20.74826415
52SIK10.73955058
53EPHB10.71797068
54MAPKAPK50.70242089
55MAP3K60.69474489
56MAPK130.66155622
57FGFR10.64948939
58TESK20.64787749
59STK30.62037930
60BMPR1B0.59889802
61AKT10.59872171
62PRKAA10.59225803
63PRKCZ0.58931144
64MAP3K140.54757981
65MKNK10.53131412
66BRD40.45164584
67MINK10.39935597
68MAP3K50.38983596
69ILK0.37174674
70PDK10.34551517
71CAMKK10.33644027
72PDGFRB0.32785989
73WNK40.31826546
74MAPK70.31461612
75RPS6KB20.31259127
76IRAK10.29258872
77MAPK120.28683769
78PBK0.28331492
79BRAF0.28131443
80MELK0.27638436
81CSNK1D0.27591611
82CAMK1G0.25935102
83RPS6KA30.25582731
84NTRK30.24409194
85ADRBK20.23308484
86GSK3A0.23307517
87MAPK10.23168094
88PDPK10.22611430
89GSK3B0.22562926
90MAPK80.21538074
91PRKD20.21361459
92CSNK1A1L0.20761456
93STK110.18926669
94MAPK110.18098158
95RET0.17906417
96MAP3K10.17286308
97PRKCE0.15196571
98NEK90.15102551
99FER0.14656744
100IKBKB0.14356516

Predicted pathways (KEGG)

RankGene SetZ-score
1beta-Alanine metabolism_Homo sapiens_hsa004103.14489131
2Butanoate metabolism_Homo sapiens_hsa006503.01794286
3Histidine metabolism_Homo sapiens_hsa003402.76024529
4Olfactory transduction_Homo sapiens_hsa047402.50476564
5ABC transporters_Homo sapiens_hsa020102.49790418
6Circadian rhythm_Homo sapiens_hsa047102.44567770
7Insulin resistance_Homo sapiens_hsa049312.14209973
8Vitamin digestion and absorption_Homo sapiens_hsa049772.10898966
9Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.69543635
10Mineral absorption_Homo sapiens_hsa049781.66181225
11Phenylalanine metabolism_Homo sapiens_hsa003601.66000882
12Salivary secretion_Homo sapiens_hsa049701.62072995
13Longevity regulating pathway - mammal_Homo sapiens_hsa042111.61771037
14Arachidonic acid metabolism_Homo sapiens_hsa005901.58177434
15Adherens junction_Homo sapiens_hsa045201.54554380
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51279029
17Prostate cancer_Homo sapiens_hsa052151.48272142
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45853362
19MicroRNAs in cancer_Homo sapiens_hsa052061.42006941
20Fructose and mannose metabolism_Homo sapiens_hsa000511.41138164
21Lysine degradation_Homo sapiens_hsa003101.39452263
22Bile secretion_Homo sapiens_hsa049761.35756850
23Arginine biosynthesis_Homo sapiens_hsa002201.34747652
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.34722373
25Type II diabetes mellitus_Homo sapiens_hsa049301.29441131
26AMPK signaling pathway_Homo sapiens_hsa041521.29154544
27Vascular smooth muscle contraction_Homo sapiens_hsa042701.29052382
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22259268
29Retinol metabolism_Homo sapiens_hsa008301.21960297
30Ovarian steroidogenesis_Homo sapiens_hsa049131.20885783
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.20070881
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18309538
33TNF signaling pathway_Homo sapiens_hsa046681.14002980
34Serotonergic synapse_Homo sapiens_hsa047261.10724484
35Fatty acid degradation_Homo sapiens_hsa000711.10679999
36Adipocytokine signaling pathway_Homo sapiens_hsa049201.09752239
37Fatty acid metabolism_Homo sapiens_hsa012121.08500110
38Acute myeloid leukemia_Homo sapiens_hsa052211.06945391
39Propanoate metabolism_Homo sapiens_hsa006401.06231373
40mTOR signaling pathway_Homo sapiens_hsa041501.05444102
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04771525
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04165228
43Cocaine addiction_Homo sapiens_hsa050301.03999532
44FoxO signaling pathway_Homo sapiens_hsa040681.00410789
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.00133585
46Choline metabolism in cancer_Homo sapiens_hsa052310.97174237
47cAMP signaling pathway_Homo sapiens_hsa040240.96724813
48Peroxisome_Homo sapiens_hsa041460.96647478
49Linoleic acid metabolism_Homo sapiens_hsa005910.94741588
50B cell receptor signaling pathway_Homo sapiens_hsa046620.93639778
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89989413
52Insulin secretion_Homo sapiens_hsa049110.89390969
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87767070
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83093940
55Glucagon signaling pathway_Homo sapiens_hsa049220.79035735
56Notch signaling pathway_Homo sapiens_hsa043300.76777044
57Nitrogen metabolism_Homo sapiens_hsa009100.75974781
58Estrogen signaling pathway_Homo sapiens_hsa049150.74727872
59Cholinergic synapse_Homo sapiens_hsa047250.74617654
60Amphetamine addiction_Homo sapiens_hsa050310.72307180
61Renin-angiotensin system_Homo sapiens_hsa046140.71688343
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68798746
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67658966
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.66454916
65Calcium signaling pathway_Homo sapiens_hsa040200.66258893
66PPAR signaling pathway_Homo sapiens_hsa033200.63604537
67Tight junction_Homo sapiens_hsa045300.62210230
68Tyrosine metabolism_Homo sapiens_hsa003500.61040248
69Renin secretion_Homo sapiens_hsa049240.59101006
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57382277
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56762591
72Melanogenesis_Homo sapiens_hsa049160.56016232
73ErbB signaling pathway_Homo sapiens_hsa040120.55747364
74Insulin signaling pathway_Homo sapiens_hsa049100.53629420
75Tryptophan metabolism_Homo sapiens_hsa003800.52727495
76Dorso-ventral axis formation_Homo sapiens_hsa043200.52026950
77Oxytocin signaling pathway_Homo sapiens_hsa049210.51143871
78Thyroid hormone synthesis_Homo sapiens_hsa049180.51112778
79Chemical carcinogenesis_Homo sapiens_hsa052040.50382279
80Arginine and proline metabolism_Homo sapiens_hsa003300.48083714
81T cell receptor signaling pathway_Homo sapiens_hsa046600.47589555
82VEGF signaling pathway_Homo sapiens_hsa043700.47555414
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45436353
84One carbon pool by folate_Homo sapiens_hsa006700.44288514
85Prolactin signaling pathway_Homo sapiens_hsa049170.43568965
86Regulation of autophagy_Homo sapiens_hsa041400.43545787
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43268698
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.43244962
89MAPK signaling pathway_Homo sapiens_hsa040100.42203415
90Rap1 signaling pathway_Homo sapiens_hsa040150.42070149
91Chronic myeloid leukemia_Homo sapiens_hsa052200.42004906
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40353478
93HIF-1 signaling pathway_Homo sapiens_hsa040660.40107446
94Complement and coagulation cascades_Homo sapiens_hsa046100.39362317
95Dilated cardiomyopathy_Homo sapiens_hsa054140.39291346
96Hepatitis C_Homo sapiens_hsa051600.38366665
97Glioma_Homo sapiens_hsa052140.38340500
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36347206
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32663865
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32328030

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