OR51E1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)4.89507489
2atrioventricular valve morphogenesis (GO:0003181)4.80156336
3regulation of DNA methylation (GO:0044030)4.46273693
4relaxation of smooth muscle (GO:0044557)4.20277907
5glomerular filtration (GO:0003094)3.91406065
6regulation of lipoprotein metabolic process (GO:0050746)3.89004396
7iron ion import (GO:0097286)3.77004920
8regulation of cell maturation (GO:1903429)3.75433511
9positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.74750641
10regulation of acrosome reaction (GO:0060046)3.70505417
11cGMP-mediated signaling (GO:0019934)3.68964611
12negative regulation of hormone metabolic process (GO:0032351)3.68171359
13negative regulation of smooth muscle contraction (GO:0045986)3.67557877
14neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.62702164
15regulation of steroid hormone secretion (GO:2000831)3.62118415
16renal filtration (GO:0097205)3.59488363
17negative regulation of hormone biosynthetic process (GO:0032353)3.57389360
18import into cell (GO:0098657)3.54198290
19cell migration involved in heart development (GO:0060973)3.43785104
20negative regulation of muscle contraction (GO:0045932)3.37935168
21complement activation, alternative pathway (GO:0006957)3.33149425
22serotonin metabolic process (GO:0042428)3.29113912
23detection of temperature stimulus (GO:0016048)3.28218278
24endocardial cushion morphogenesis (GO:0003203)3.21346647
25retinal cone cell development (GO:0046549)3.10976868
26endocrine hormone secretion (GO:0060986)3.10566924
27meiotic cell cycle (GO:0051321)3.08371146
28retina vasculature morphogenesis in camera-type eye (GO:0061299)3.04987621
29negative regulation of protein localization to cell surface (GO:2000009)3.02131629
30negative regulation of reproductive process (GO:2000242)3.01240058
31ventricular septum morphogenesis (GO:0060412)3.00578198
32triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.97555833
33bundle of His cell to Purkinje myocyte communication (GO:0086069)2.96718668
34epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.93353479
35myofibril assembly (GO:0030239)2.92613336
36interkinetic nuclear migration (GO:0022027)2.87588910
37actin-myosin filament sliding (GO:0033275)2.79175848
38muscle filament sliding (GO:0030049)2.79175848
39basement membrane organization (GO:0071711)2.78334248
40positive regulation of digestive system process (GO:0060456)2.77895631
41primary amino compound metabolic process (GO:1901160)2.77877793
42relaxation of muscle (GO:0090075)2.76427568
43heart valve morphogenesis (GO:0003179)2.74903377
44cardiac myofibril assembly (GO:0055003)2.73807474
45regulation of sequestering of triglyceride (GO:0010889)2.72547584
46piRNA metabolic process (GO:0034587)2.70952792
47histone H3-K9 demethylation (GO:0033169)2.69364558
48auditory receptor cell differentiation (GO:0042491)2.68045469
49negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.64744767
50regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.63856887
51regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.63559922
52actin-mediated cell contraction (GO:0070252)2.60444994
53vascular endothelial growth factor signaling pathway (GO:0038084)2.58643055
54response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.58095602
55regulation of G0 to G1 transition (GO:0070316)2.56206409
56regulation of endocrine process (GO:0044060)2.55114897
57multicellular organism reproduction (GO:0032504)2.52237866
58skeletal muscle adaptation (GO:0043501)2.50259478
59negative regulation of homotypic cell-cell adhesion (GO:0034111)2.47703905
60positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.46541490
61regulation of triglyceride catabolic process (GO:0010896)2.46007751
62protein heterotrimerization (GO:0070208)2.45621961
63collagen fibril organization (GO:0030199)2.45362466
64female gamete generation (GO:0007292)2.44023983
65epithelial cell-cell adhesion (GO:0090136)2.40467426
66embryonic retina morphogenesis in camera-type eye (GO:0060059)2.40380013
67relaxation of cardiac muscle (GO:0055119)2.37921713
68dermatan sulfate metabolic process (GO:0030205)2.37732594
69ovulation cycle (GO:0042698)2.37574379
70glomerular basement membrane development (GO:0032836)2.37354631
71regulation of fatty acid oxidation (GO:0046320)2.35902507
72positive regulation of steroid hormone secretion (GO:2000833)2.35835217
73oocyte development (GO:0048599)2.35418240
74mesenchyme morphogenesis (GO:0072132)2.35120595
75endodermal cell differentiation (GO:0035987)2.35000694
76labyrinthine layer development (GO:0060711)2.34648294
77glycine transport (GO:0015816)2.32179120
78positive regulation of fatty acid oxidation (GO:0046321)2.30028570
79gene silencing by RNA (GO:0031047)2.28539182
80regulation of meiosis I (GO:0060631)2.28275791
81artery development (GO:0060840)2.27365830
82regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.27038209
83genitalia morphogenesis (GO:0035112)2.26102057
84fibroblast migration (GO:0010761)2.24906343
85actomyosin structure organization (GO:0031032)2.24475477
86retinal metabolic process (GO:0042574)2.24370658
87positive regulation of microtubule polymerization (GO:0031116)2.24346288
88peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.23746811
89dermatan sulfate biosynthetic process (GO:0030208)2.23152982
90positive regulation of glycolytic process (GO:0045821)2.22518538
91regulation of skeletal muscle contraction (GO:0014819)2.21669225
92cellular response to epinephrine stimulus (GO:0071872)2.21519345
93lymphangiogenesis (GO:0001946)2.21297868
94fatty acid transmembrane transport (GO:1902001)2.20885744
95insulin-like growth factor receptor signaling pathway (GO:0048009)2.20736574
96negative regulation of macrophage differentiation (GO:0045650)2.19653500
97negative regulation of potassium ion transmembrane transport (GO:1901380)2.19407131
98cAMP catabolic process (GO:0006198)2.19350485
99cardiac septum morphogenesis (GO:0060411)2.18713537
100positive regulation of fatty acid beta-oxidation (GO:0032000)2.17814160

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.34039017
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.60619178
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.40945045
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.45001421
5EP300_21415370_ChIP-Seq_HL-1_Mouse2.43012425
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.23572481
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.23572481
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.23572481
9PIAS1_25552417_ChIP-Seq_VCAP_Human2.10445857
10DROSHA_22980978_ChIP-Seq_HELA_Human1.92011431
11ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.86209554
12ESR2_21235772_ChIP-Seq_MCF-7_Human1.82787032
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.82724606
14AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79353487
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73748453
16ZNF217_24962896_ChIP-Seq_MCF-7_Human1.73178349
17HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.72868766
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69375684
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.67722936
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65631213
21AR_21572438_ChIP-Seq_LNCaP_Human1.64334236
22CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.59289266
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.48576964
24VDR_22108803_ChIP-Seq_LS180_Human1.47570710
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.45241405
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.42609452
27AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.39425639
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37799921
29ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37449686
30TBX20_22080862_ChIP-Seq_HEART_Mouse1.37244788
31TBX20_22328084_ChIP-Seq_HEART_Mouse1.37244788
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37112427
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36856612
34FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.36220567
35FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36191869
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.34561308
37NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33701949
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33571938
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33294285
40AHR_22903824_ChIP-Seq_MCF-7_Human1.31286995
41GBX2_23144817_ChIP-Seq_PC3_Human1.29617329
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28540630
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.28496842
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28416593
45NFIB_24661679_ChIP-Seq_LUNG_Mouse1.24822922
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24764217
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23388108
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.22690550
49CJUN_26792858_Chip-Seq_BT549_Human1.20837569
50SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18734280
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18491235
52SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18162485
53AR_25329375_ChIP-Seq_VCAP_Human1.16942912
54SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16590184
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15929503
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15764063
57CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15725987
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.14729104
59EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13088502
60LXR_22158963_ChIP-Seq_LIVER_Mouse1.13007257
61FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11338628
62PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.09513846
63TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08965078
64SMAD4_21799915_ChIP-Seq_A2780_Human1.08632087
65JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06962633
66EZH2_27304074_Chip-Seq_ESCs_Mouse1.05487700
67NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05125470
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05125470
69SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04793935
70RNF2_18974828_ChIP-Seq_MESCs_Mouse1.04046296
71EZH2_18974828_ChIP-Seq_MESCs_Mouse1.04046296
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.03382528
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02921497
74SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02873925
75LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02351913
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00748208
77GF1_26923725_Chip-Seq_HPCs_Mouse1.00320164
78TCF4_18268006_ChIP-ChIP_LS174T_Human0.98940823
79TCF4_23295773_ChIP-Seq_U87_Human0.98891022
80GATA2_21666600_ChIP-Seq_HMVEC_Human0.98193032
81FOXA2_19822575_ChIP-Seq_HepG2_Human0.98139109
82SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96880337
83TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95738477
84BP1_19119308_ChIP-ChIP_Hs578T_Human0.94059495
85SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94052567
86CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93252318
87TP53_16413492_ChIP-PET_HCT116_Human0.92980993
88RXR_22108803_ChIP-Seq_LS180_Human0.92691753
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92531949
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91372033
91RNF2_27304074_Chip-Seq_ESCs_Mouse0.90914704
92RUNX2_22187159_ChIP-Seq_PCA_Human0.90477793
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89595967
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89595967
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89009189
96PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88901941
97JARID2_20064375_ChIP-Seq_MESCs_Mouse0.88586265
98SMAD4_21741376_ChIP-Seq_HESCs_Human0.88457897
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87587347
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87142662

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology4.58992043
2MP0008438_abnormal_cutaneous_collagen3.97263330
3MP0005670_abnormal_white_adipose3.37526964
4MP0003718_maternal_effect3.35806856
5MP0005275_abnormal_skin_tensile3.04930299
6MP0004084_abnormal_cardiac_muscle3.03074126
7MP0003879_abnormal_hair_cell2.78389072
8MP0004272_abnormal_basement_membrane2.68840795
9MP0004145_abnormal_muscle_electrophysio2.55614001
10MP0004036_abnormal_muscle_relaxation2.55258749
11MP0000751_myopathy2.43492315
12MP0002108_abnormal_muscle_morphology2.43151368
13MP0003646_muscle_fatigue2.24561509
14MP0004043_abnormal_pH_regulation2.16875016
15MP0006138_congestive_heart_failure2.16873379
16MP0003279_aneurysm2.05600723
17MP0002735_abnormal_chemical_nociception2.00921892
18MP0005167_abnormal_blood-brain_barrier1.93621280
19MP0005666_abnormal_adipose_tissue1.86103793
20MP0005620_abnormal_muscle_contractility1.83754169
21MP0001664_abnormal_digestion1.83461475
22MP0010368_abnormal_lymphatic_system1.76883982
23MP0004130_abnormal_muscle_cell1.72945993
24MP0000749_muscle_degeneration1.64429853
25MP0005395_other_phenotype1.63902781
26MP0003950_abnormal_plasma_membrane1.63265131
27MP0002876_abnormal_thyroid_physiology1.59957982
28MP0001542_abnormal_bone_strength1.56880211
29MP0008789_abnormal_olfactory_epithelium1.53917084
30MP0002234_abnormal_pharynx_morphology1.51624725
31MP0005369_muscle_phenotype1.51526842
32MP0000767_abnormal_smooth_muscle1.51184965
33MP0000747_muscle_weakness1.50173500
34MP0000230_abnormal_systemic_arterial1.46661801
35MP0009840_abnormal_foam_cell1.42816682
36MP0006276_abnormal_autonomic_nervous1.40479285
37MP0004087_abnormal_muscle_fiber1.38859886
38MP0005375_adipose_tissue_phenotype1.38114694
39MP0008775_abnormal_heart_ventricle1.37914851
40MP0000759_abnormal_skeletal_muscle1.34774712
41MP0002106_abnormal_muscle_physiology1.33780718
42MP0005187_abnormal_penis_morphology1.33216773
43MP0002971_abnormal_brown_adipose1.30980590
44MP0000013_abnormal_adipose_tissue1.28329575
45MP0005360_urolithiasis1.24517054
46MP0002972_abnormal_cardiac_muscle1.22364190
47MP0004085_abnormal_heartbeat1.21948444
48MP0005647_abnormal_sex_gland1.21215624
49MP0003890_abnormal_embryonic-extraembry1.20712957
50MP0002332_abnormal_exercise_endurance1.20358517
51MP0005085_abnormal_gallbladder_physiolo1.18731210
52MP0003959_abnormal_lean_body1.16656721
53MP0001879_abnormal_lymphatic_vessel1.15453440
54MP0003091_abnormal_cell_migration1.12969344
55MP0000733_abnormal_muscle_development1.12241036
56MP0004215_abnormal_myocardial_fiber1.12191394
57MP0009250_abnormal_appendicular_skeleto1.11570302
58MP0010329_abnormal_lipoprotein_level1.10913636
59MP0000003_abnormal_adipose_tissue1.08239305
60MP0001501_abnormal_sleep_pattern1.06471428
61MP0005257_abnormal_intraocular_pressure1.05824381
62MP0002909_abnormal_adrenal_gland1.05099266
63MP0005330_cardiomyopathy1.03193796
64MP0001756_abnormal_urination1.03081333
65MP0002127_abnormal_cardiovascular_syste1.01977293
66MP0005595_abnormal_vascular_smooth1.00728776
67MP0002933_joint_inflammation0.99914259
68MP0004858_abnormal_nervous_system0.98746911
69MP0003566_abnormal_cell_adhesion0.96575960
70MP0001544_abnormal_cardiovascular_syste0.96040354
71MP0005385_cardiovascular_system_phenoty0.96040354
72MP0003868_abnormal_feces_composition0.94302189
73MP0005499_abnormal_olfactory_system0.93896521
74MP0005394_taste/olfaction_phenotype0.93896521
75MP0009115_abnormal_fat_cell0.92562001
76MP0002896_abnormal_bone_mineralization0.91059584
77MP0001502_abnormal_circadian_rhythm0.90983406
78MP0003136_yellow_coat_color0.90947736
79MP0003699_abnormal_female_reproductive0.87894441
80MP0000762_abnormal_tongue_morphology0.86610534
81MP0002269_muscular_atrophy0.84546389
82MP0003183_abnormal_peptide_metabolism0.84094016
83MP0005266_abnormal_metabolism0.83691467
84MP0000750_abnormal_muscle_regeneration0.83230984
85MP0009384_cardiac_valve_regurgitation0.83128151
86MP0001765_abnormal_ion_homeostasis0.83105586
87MP0002098_abnormal_vibrissa_morphology0.82660741
88MP0002736_abnormal_nociception_after0.82307754
89MP0005508_abnormal_skeleton_morphology0.80728071
90MP0003252_abnormal_bile_duct0.80438971
91MP0002128_abnormal_blood_circulation0.80136993
92MP0010630_abnormal_cardiac_muscle0.80036363
93MP0004510_myositis0.79424706
94MP0005409_darkened_coat_color0.76254410
95MP0003705_abnormal_hypodermis_morpholog0.75031401
96MP0001958_emphysema0.72091450
97MP0002078_abnormal_glucose_homeostasis0.71514261
98MP0002090_abnormal_vision0.69787712
99MP0005452_abnormal_adipose_tissue0.69207515
100MP0002118_abnormal_lipid_homeostasis0.68765235

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.29268091
2Type 1 muscle fiber predominance (HP:0003803)4.77736012
3Aortic dissection (HP:0002647)4.42643666
4Aortic aneurysm (HP:0004942)4.16313112
5Malnutrition (HP:0004395)4.03641999
6Bundle branch block (HP:0011710)4.02717644
7Muscle fiber inclusion bodies (HP:0100299)3.62448329
8Nemaline bodies (HP:0003798)3.55758127
9Anterior segment dysgenesis (HP:0007700)3.55384648
10Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.50737450
11Exercise-induced myalgia (HP:0003738)3.40317229
12Cerebral aneurysm (HP:0004944)3.13797127
13Asymmetric septal hypertrophy (HP:0001670)3.11568872
14Soft skin (HP:0000977)3.08286160
15Osteomalacia (HP:0002749)3.03159919
16Abnormality of abdominal situs (HP:0011620)2.99129008
17Abdominal situs inversus (HP:0003363)2.99129008
18Increased variability in muscle fiber diameter (HP:0003557)2.91126384
19Ventricular tachycardia (HP:0004756)2.90791596
20Hypophosphatemic rickets (HP:0004912)2.88136335
21Shallow orbits (HP:0000586)2.77889358
22Hypercortisolism (HP:0001578)2.77451837
23Sudden death (HP:0001699)2.77221474
24Genetic anticipation (HP:0003743)2.68158644
25Neoplasm of the heart (HP:0100544)2.62064020
26Abnormality of skeletal muscle fiber size (HP:0012084)2.61491033
27Dysmetric saccades (HP:0000641)2.56706747
28Abnormality of the calf musculature (HP:0001430)2.56521705
29Blue sclerae (HP:0000592)2.54630819
30Muscle fiber splitting (HP:0003555)2.53433915
31Fragile skin (HP:0001030)2.52446849
32Hip contracture (HP:0003273)2.51817172
33Obstructive sleep apnea (HP:0002870)2.50154771
34Round ear (HP:0100830)2.48957634
35Myotonia (HP:0002486)2.41845345
36Muscle hypertrophy of the lower extremities (HP:0008968)2.40212773
37Bone cyst (HP:0012062)2.35840386
38Mildly elevated creatine phosphokinase (HP:0008180)2.34765425
39Hyporeflexia of lower limbs (HP:0002600)2.33756415
40Neck muscle weakness (HP:0000467)2.31144505
41Heart block (HP:0012722)2.29944228
42Broad metatarsal (HP:0001783)2.28378269
43Abnormality of Sharpey fibers (HP:0100685)2.27635819
44Calf muscle hypertrophy (HP:0008981)2.25645737
45Abnormal atrioventricular conduction (HP:0005150)2.22676318
46Infantile muscular hypotonia (HP:0008947)2.20754768
47Peritonitis (HP:0002586)2.18718682
48Cranial hyperostosis (HP:0004437)2.18087204
49Hyperextensible skin (HP:0000974)2.16851949
50Aneurysm (HP:0002617)2.13888077
51Abnormality of the ischium (HP:0003174)2.13016574
52Premature ovarian failure (HP:0008209)2.11788234
53Tibial bowing (HP:0002982)2.09939086
54Polar cataract (HP:0010696)2.09064235
55Proximal tubulopathy (HP:0000114)2.08783350
56Lip pit (HP:0100267)2.08435817
57Decreased circulating renin level (HP:0003351)2.07782197
58Mitral valve prolapse (HP:0001634)2.07020685
59Ankle contracture (HP:0006466)2.06558111
60Spinal rigidity (HP:0003306)2.06391764
61Increased connective tissue (HP:0009025)2.06359832
62Supernumerary spleens (HP:0009799)2.05218796
63Aplasia of the musculature (HP:0100854)2.05141319
64Papillary thyroid carcinoma (HP:0002895)2.03056600
65Long eyelashes (HP:0000527)2.01005592
66Hemorrhage of the eye (HP:0011885)1.99394443
67Lipoatrophy (HP:0100578)1.98618205
68Wrist flexion contracture (HP:0001239)1.98314782
69Hyperkalemia (HP:0002153)1.98305352
70Atrial fibrillation (HP:0005110)1.98236345
71Abnormality of molar (HP:0011077)1.97731930
72Abnormality of molar morphology (HP:0011070)1.97731930
73Muscle stiffness (HP:0003552)1.97490663
74Vertebral arch anomaly (HP:0008438)1.97156031
75Thin bony cortex (HP:0002753)1.96332966
76Hypoplastic ischia (HP:0003175)1.96208163
77Axonal loss (HP:0003447)1.96141668
78Nephritis (HP:0000123)1.95133394
79Spondylolisthesis (HP:0003302)1.94468501
80Abnormality of the anterior chamber (HP:0000593)1.93796730
81Hyperparathyroidism (HP:0000843)1.92876994
82Ulnar deviation of the wrist (HP:0003049)1.91850839
83Bladder diverticulum (HP:0000015)1.89566761
84Truncal obesity (HP:0001956)1.88207836
85Glomerulonephritis (HP:0000099)1.87999695
86Distal arthrogryposis (HP:0005684)1.84494363
87Craniofacial hyperostosis (HP:0004493)1.83956586
88Follicular hyperkeratosis (HP:0007502)1.83472912
89Azoospermia (HP:0000027)1.82018759
90Hemiplegia (HP:0002301)1.80681847
91Limited hip movement (HP:0008800)1.79597168
92Renal tubular acidosis (HP:0001947)1.79365080
93Mitral stenosis (HP:0001718)1.78846694
94Stroke (HP:0001297)1.78708252
95Chondrocalcinosis (HP:0000934)1.78306672
96EMG: myopathic abnormalities (HP:0003458)1.77766300
97Striae distensae (HP:0001065)1.76726712
98Hypoplasia of the iris (HP:0007676)1.76036354
99Myopathic facies (HP:0002058)1.75515489
100Abnormality of dentin (HP:0010299)1.75061480

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK3.91068172
2MAP3K133.78141512
3ICK3.16855128
4AKT33.09638421
5DMPK3.04188681
6FRK2.92260432
7OBSCN2.72627815
8ARAF2.54956516
9MAP3K92.38611160
10RIPK12.28948189
11MET2.08610293
12TTN2.02015845
13STK391.82064846
14MOS1.63644377
15TIE11.62621669
16NEK61.62535681
17ILK1.61644723
18CAMK1D1.57926740
19MAP3K71.52467139
20CDK121.50279040
21CDC42BPA1.43799053
22PIK3CG1.42843331
23NEK91.41618008
24TRIB31.41330781
25TRPM71.40987761
26STK38L1.39112311
27PRKD31.35360945
28TAOK31.34583431
29MAPKAPK31.32244967
30PDGFRA1.22142180
31PRKAA21.20455068
32PAK21.17346106
33ACVR1B1.13333099
34STK381.11539019
35CAMK1G1.09216914
36CDK91.08187616
37PTK21.07963061
38BRAF1.07300247
39KIT1.06955310
40EPHA31.05103344
41CAMK11.04942645
42MARK21.01650778
43STK241.01615546
44LATS11.01345455
45SIK10.99977527
46IRAK10.97150648
47PRKAA10.97101252
48EEF2K0.97003803
49NTRK30.92648372
50DDR20.87657528
51PDGFRB0.87164819
52TGFBR20.86824449
53KSR20.86677716
54PRKG10.85636283
55PAK30.83112810
56TNK20.81059178
57PKN10.80020118
58PDPK10.79554655
59PHKG10.78269588
60PHKG20.78269588
61MTOR0.75244247
62MELK0.75129875
63DAPK30.73613061
64MAP2K10.73204954
65PRKD20.71631008
66PIK3CA0.71225169
67ROCK10.69850397
68ERN10.66768309
69CDK80.64509345
70BRSK20.62087376
71PDK10.61198184
72SGK20.60270739
73MAPK70.56959083
74MST1R0.55443062
75PRKG20.55368970
76CAMK2B0.51022313
77CAMKK20.50922935
78LMTK20.49921824
79RAF10.49670449
80CAMK2A0.48423808
81PRKACA0.48139490
82BMPR1B0.48106519
83WNK10.47503275
84ADRBK10.47465912
85EPHB20.46825861
86MAPK120.46359160
87CAMKK10.46246782
88LATS20.46112961
89CDK70.44127793
90PRKACG0.43923114
91CAMK2G0.43848533
92MAPK150.42092725
93MAP3K30.40711558
94MAPK40.40234412
95PRKCE0.38008421
96RET0.35536258
97TGFBR10.35531642
98SGK2230.35089545
99SGK4940.35089545
100PRKD10.34918899

Predicted pathways (KEGG)

RankGene SetZ-score
1Vascular smooth muscle contraction_Homo sapiens_hsa042702.39595006
2Circadian rhythm_Homo sapiens_hsa047102.28334517
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.21779771
4Dilated cardiomyopathy_Homo sapiens_hsa054142.21389030
5ECM-receptor interaction_Homo sapiens_hsa045122.19847601
6Phenylalanine metabolism_Homo sapiens_hsa003602.19259777
7Ovarian steroidogenesis_Homo sapiens_hsa049132.18522288
8Dorso-ventral axis formation_Homo sapiens_hsa043202.02754259
9Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.01640081
10ABC transporters_Homo sapiens_hsa020101.80645671
11Histidine metabolism_Homo sapiens_hsa003401.68889785
12Bile secretion_Homo sapiens_hsa049761.65648529
13Focal adhesion_Homo sapiens_hsa045101.55647383
14Protein digestion and absorption_Homo sapiens_hsa049741.55598467
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.53052619
16PPAR signaling pathway_Homo sapiens_hsa033201.49597168
17cGMP-PKG signaling pathway_Homo sapiens_hsa040221.46053827
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43317451
19Renin secretion_Homo sapiens_hsa049241.38449609
20Amoebiasis_Homo sapiens_hsa051461.33728559
21Longevity regulating pathway - mammal_Homo sapiens_hsa042111.31916425
22AMPK signaling pathway_Homo sapiens_hsa041521.28559040
23Arginine biosynthesis_Homo sapiens_hsa002201.28403784
24Vitamin digestion and absorption_Homo sapiens_hsa049771.26509688
25Adipocytokine signaling pathway_Homo sapiens_hsa049201.18885863
26Insulin resistance_Homo sapiens_hsa049311.17541069
27Tryptophan metabolism_Homo sapiens_hsa003801.17465150
28Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.12198213
29Fatty acid biosynthesis_Homo sapiens_hsa000611.11868484
30Insulin signaling pathway_Homo sapiens_hsa049101.05544210
31Cocaine addiction_Homo sapiens_hsa050301.03519045
32Small cell lung cancer_Homo sapiens_hsa052221.01337606
33Insulin secretion_Homo sapiens_hsa049110.99777275
34FoxO signaling pathway_Homo sapiens_hsa040680.98608123
35Glucagon signaling pathway_Homo sapiens_hsa049220.98050091
36Arginine and proline metabolism_Homo sapiens_hsa003300.97483600
37Prion diseases_Homo sapiens_hsa050200.96371258
38Oxytocin signaling pathway_Homo sapiens_hsa049210.96300026
39Cholinergic synapse_Homo sapiens_hsa047250.93773878
40Renin-angiotensin system_Homo sapiens_hsa046140.93353561
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92981240
42Lysine degradation_Homo sapiens_hsa003100.91931829
43Complement and coagulation cascades_Homo sapiens_hsa046100.89422971
44TGF-beta signaling pathway_Homo sapiens_hsa043500.88603665
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88405340
46cAMP signaling pathway_Homo sapiens_hsa040240.88006703
47* Olfactory transduction_Homo sapiens_hsa047400.87997374
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87748282
49Serotonergic synapse_Homo sapiens_hsa047260.87328640
50Notch signaling pathway_Homo sapiens_hsa043300.86291834
51Morphine addiction_Homo sapiens_hsa050320.85307918
52Cardiac muscle contraction_Homo sapiens_hsa042600.85086583
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.84079245
54Thyroid hormone synthesis_Homo sapiens_hsa049180.82701333
55Amphetamine addiction_Homo sapiens_hsa050310.81431187
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80629329
57Calcium signaling pathway_Homo sapiens_hsa040200.79929739
58Circadian entrainment_Homo sapiens_hsa047130.79216164
59mTOR signaling pathway_Homo sapiens_hsa041500.78851753
60Long-term depression_Homo sapiens_hsa047300.77916035
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76584116
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76557507
63Fat digestion and absorption_Homo sapiens_hsa049750.76159561
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75859286
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74027391
66Estrogen signaling pathway_Homo sapiens_hsa049150.72884697
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72878570
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.72511209
69Prostate cancer_Homo sapiens_hsa052150.72223206
70Caffeine metabolism_Homo sapiens_hsa002320.71740635
71Gap junction_Homo sapiens_hsa045400.71495236
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70994408
73Linoleic acid metabolism_Homo sapiens_hsa005910.70456472
74Adherens junction_Homo sapiens_hsa045200.70028331
75PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69298835
76Taste transduction_Homo sapiens_hsa047420.66709402
77Glycerolipid metabolism_Homo sapiens_hsa005610.66596414
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64993554
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.64812874
80Tight junction_Homo sapiens_hsa045300.64660742
81Nitrogen metabolism_Homo sapiens_hsa009100.62712374
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62230517
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.62121296
84beta-Alanine metabolism_Homo sapiens_hsa004100.60849834
85Sulfur relay system_Homo sapiens_hsa041220.60134158
86Arachidonic acid metabolism_Homo sapiens_hsa005900.57773457
87Melanoma_Homo sapiens_hsa052180.57115406
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56218014
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54882583
90Salivary secretion_Homo sapiens_hsa049700.54737542
91Gastric acid secretion_Homo sapiens_hsa049710.54648338
92Fatty acid degradation_Homo sapiens_hsa000710.53907626
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53812442
94Tyrosine metabolism_Homo sapiens_hsa003500.53618268
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52895926
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52597940
97Pancreatic secretion_Homo sapiens_hsa049720.51206007
98Nicotine addiction_Homo sapiens_hsa050330.50869491
99Oocyte meiosis_Homo sapiens_hsa041140.50844501
100Choline metabolism in cancer_Homo sapiens_hsa052310.48880060

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