OR51E2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adaptation of signaling pathway (GO:0023058)7.48550327
2negative regulation of systemic arterial blood pressure (GO:0003085)5.33241606
3negative regulation of sodium ion transport (GO:0010766)4.45776622
4retinal metabolic process (GO:0042574)4.33117409
5positive regulation of digestive system process (GO:0060456)4.27975334
6negative regulation of protein localization to cell surface (GO:2000009)4.25736816
7indolalkylamine metabolic process (GO:0006586)4.07067033
8positive regulation of chemokine secretion (GO:0090197)3.98776582
9amine catabolic process (GO:0009310)3.96508574
10cellular biogenic amine catabolic process (GO:0042402)3.96508574
11indolalkylamine catabolic process (GO:0046218)3.95851613
12tryptophan catabolic process (GO:0006569)3.95851613
13indole-containing compound catabolic process (GO:0042436)3.95851613
14behavioral response to nicotine (GO:0035095)3.81376906
15tryptophan metabolic process (GO:0006568)3.75323708
16kynurenine metabolic process (GO:0070189)3.74476884
17interkinetic nuclear migration (GO:0022027)3.67869611
18regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.59554168
19regulation of hippo signaling (GO:0035330)3.53414024
20benzene-containing compound metabolic process (GO:0042537)3.50328023
21regulation of memory T cell differentiation (GO:0043380)3.43640534
22detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.38682225
23iron ion import (GO:0097286)3.32662349
24response to pheromone (GO:0019236)3.31596745
25toxin transport (GO:1901998)3.31062641
26signal peptide processing (GO:0006465)3.26131535
27negative regulation of cAMP-mediated signaling (GO:0043951)3.25320890
28cellular ketone body metabolic process (GO:0046950)3.24951933
29ketone body metabolic process (GO:1902224)3.21890594
30reflex (GO:0060004)3.21031710
31import into cell (GO:0098657)3.20834988
32negative regulation of multicellular organism growth (GO:0040015)3.19839318
33regulation of chemokine secretion (GO:0090196)3.18915820
34intestinal epithelial cell development (GO:0060576)3.17866341
35positive regulation of fatty acid oxidation (GO:0046321)3.12178341
36L-fucose catabolic process (GO:0042355)3.02685988
37fucose catabolic process (GO:0019317)3.02685988
38L-fucose metabolic process (GO:0042354)3.02685988
39G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.02516406
40indole-containing compound metabolic process (GO:0042430)3.02286597
41regulation of fatty acid oxidation (GO:0046320)3.01537700
42negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.01473561
43negative regulation of translation, ncRNA-mediated (GO:0040033)3.01473561
44regulation of translation, ncRNA-mediated (GO:0045974)3.01473561
45ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.99003094
46diterpenoid biosynthetic process (GO:0016102)2.98192637
47short-chain fatty acid metabolic process (GO:0046459)2.93377013
48positive regulation of glycolytic process (GO:0045821)2.92295167
49branching involved in prostate gland morphogenesis (GO:0060442)2.91290759
50sequestering of extracellular ligand from receptor (GO:0035581)2.90313735
51primary amino compound metabolic process (GO:1901160)2.84886976
52DNA deamination (GO:0045006)2.80301579
53organic cation transport (GO:0015695)2.79331496
54terpenoid biosynthetic process (GO:0016114)2.78677245
55epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.75552160
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.72665178
57righting reflex (GO:0060013)2.70748216
58serotonin metabolic process (GO:0042428)2.70397975
59piRNA metabolic process (GO:0034587)2.66200467
60sulfation (GO:0051923)2.62700869
61branched-chain amino acid catabolic process (GO:0009083)2.61842667
62protein import into peroxisome matrix (GO:0016558)2.59967816
63tachykinin receptor signaling pathway (GO:0007217)2.59751549
64cysteine metabolic process (GO:0006534)2.59062496
65long-chain fatty acid biosynthetic process (GO:0042759)2.58987570
66positive regulation of fatty acid beta-oxidation (GO:0032000)2.54975883
67neural tube formation (GO:0001841)2.54533245
68prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.53800273
69cAMP catabolic process (GO:0006198)2.53215790
70opioid receptor signaling pathway (GO:0038003)2.52390492
71cellular response to sterol (GO:0036315)2.52163923
72lung vasculature development (GO:0060426)2.49172904
73nephron tubule morphogenesis (GO:0072078)2.48514393
74nephron epithelium morphogenesis (GO:0072088)2.48514393
75retinol metabolic process (GO:0042572)2.48490309
76cellular biogenic amine biosynthetic process (GO:0042401)2.45913293
77adenosine metabolic process (GO:0046085)2.45893348
78plasma membrane repair (GO:0001778)2.44861820
79preassembly of GPI anchor in ER membrane (GO:0016254)2.44584171
80epithelial cell maturation (GO:0002070)2.43321189
81carnitine transmembrane transport (GO:1902603)2.42275759
82axoneme assembly (GO:0035082)2.42002767
83S-adenosylmethionine metabolic process (GO:0046500)2.41678547
84behavioral response to ethanol (GO:0048149)2.41111408
85detection of light stimulus involved in visual perception (GO:0050908)2.40800897
86detection of light stimulus involved in sensory perception (GO:0050962)2.40800897
87regulation of calcium ion-dependent exocytosis (GO:0017158)2.39710215
88negative regulation of blood pressure (GO:0045776)2.38421317
89negative regulation of cytosolic calcium ion concentration (GO:0051481)2.38320901
90neuronal action potential (GO:0019228)2.36662344
91valine metabolic process (GO:0006573)2.36311058
92amine biosynthetic process (GO:0009309)2.34869753
93linoleic acid metabolic process (GO:0043651)2.33415896
94regulation of digestive system process (GO:0044058)2.32780108
95phosphatidylinositol acyl-chain remodeling (GO:0036149)2.29646987
96adrenergic receptor signaling pathway (GO:0071875)2.29168033
97methionine biosynthetic process (GO:0009086)2.28927941
98multicellular organism reproduction (GO:0032504)2.28642873
99NAD biosynthetic process (GO:0009435)2.28489654
100regulation of tight junction assembly (GO:2000810)2.28233220

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.70737785
2ZNF274_21170338_ChIP-Seq_K562_Hela3.43650711
3VDR_22108803_ChIP-Seq_LS180_Human3.19539772
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.76652871
5* PIAS1_25552417_ChIP-Seq_VCAP_Human2.67691262
6AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.57362346
7GBX2_23144817_ChIP-Seq_PC3_Human2.50805746
8EZH2_22144423_ChIP-Seq_EOC_Human2.48174877
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.39803535
10IGF1R_20145208_ChIP-Seq_DFB_Human2.35340384
11AR_21572438_ChIP-Seq_LNCaP_Human2.09907392
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09177978
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.06069276
14AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.04321803
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94334840
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89275474
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83020974
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75255796
19P300_19829295_ChIP-Seq_ESCs_Human1.74387353
20* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72525692
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.72111888
22IRF1_19129219_ChIP-ChIP_H3396_Human1.66361201
23ER_23166858_ChIP-Seq_MCF-7_Human1.66122596
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63525575
25TAF15_26573619_Chip-Seq_HEK293_Human1.62981413
26EWS_26573619_Chip-Seq_HEK293_Human1.55524867
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52912311
28* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.52844410
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51947883
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51947883
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49683323
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47452102
33* CBP_20019798_ChIP-Seq_JUKART_Human1.45550541
34* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45550541
35NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43750701
36SMAD4_21799915_ChIP-Seq_A2780_Human1.41305449
37AR_25329375_ChIP-Seq_VCAP_Human1.39812418
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34719520
39STAT3_23295773_ChIP-Seq_U87_Human1.34430597
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.33558101
41ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33488741
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33089395
43TBL1_22424771_ChIP-Seq_293T_Human1.32799885
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.32661896
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32508186
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32329748
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32198193
48FUS_26573619_Chip-Seq_HEK293_Human1.32061975
49TCF4_23295773_ChIP-Seq_U87_Human1.32055020
50AHR_22903824_ChIP-Seq_MCF-7_Human1.30595090
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29610588
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27211028
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.27200178
54PRDM14_20953172_ChIP-Seq_ESCs_Human1.27118587
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26097899
56BCAT_22108803_ChIP-Seq_LS180_Human1.22382734
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.22240618
58NFYA_21822215_ChIP-Seq_K562_Human1.19977951
59NFYB_21822215_ChIP-Seq_K562_Human1.18934704
60FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18931946
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17936316
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.17839160
63FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.17711823
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16958255
65RUNX2_22187159_ChIP-Seq_PCA_Human1.16172648
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.15520196
67ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15153718
68TCF4_22108803_ChIP-Seq_LS180_Human1.13927643
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13894217
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13717953
71ESR1_21235772_ChIP-Seq_MCF-7_Human1.13479792
72PHF8_20622853_ChIP-Seq_HELA_Human1.13039054
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12855282
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.12516965
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.11417814
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07719935
77* AR_20517297_ChIP-Seq_VCAP_Human1.07712417
78CDX2_22108803_ChIP-Seq_LS180_Human1.07339636
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07205619
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.07013721
81FOXA1_25552417_ChIP-Seq_VCAP_Human1.06813854
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06426722
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.06426722
84HNFA_21074721_ChIP-Seq_CACO-2_Human1.05812427
85RXR_22108803_ChIP-Seq_LS180_Human1.05553621
86* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05316442
87* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04695523
88FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03719103
89REST_21632747_ChIP-Seq_MESCs_Mouse1.03264058
90CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02583090
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02365867
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01606580
93TP53_16413492_ChIP-PET_HCT116_Human1.00515919
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.00249522
95ETV1_20927104_ChIP-Seq_GIST48_Human0.99977700
96CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.99674074
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98804360
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98531858
99FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97336895
100TP53_22573176_ChIP-Seq_HFKS_Human0.96705509

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.90132057
2MP0003136_yellow_coat_color3.35583424
3MP0002735_abnormal_chemical_nociception2.88030983
4MP0005167_abnormal_blood-brain_barrier2.86653338
5MP0001968_abnormal_touch/_nociception2.56605961
6MP0005551_abnormal_eye_electrophysiolog2.34999049
7MP0002736_abnormal_nociception_after2.34381297
8MP0004043_abnormal_pH_regulation2.25803869
9MP0000569_abnormal_digit_pigmentation2.20299712
10MP0002653_abnormal_ependyma_morphology2.14143529
11MP0004885_abnormal_endolymph2.13164488
12MP0003195_calcinosis2.12857300
13MP0002876_abnormal_thyroid_physiology2.12612253
14MP0001501_abnormal_sleep_pattern2.11799541
15MP0005085_abnormal_gallbladder_physiolo2.11098947
16MP0005171_absent_coat_pigmentation2.07541965
17MP0000372_irregular_coat_pigmentation2.04565640
18MP0005253_abnormal_eye_physiology1.93743814
19MP0003646_muscle_fatigue1.90426704
20MP0001485_abnormal_pinna_reflex1.89845051
21MP0005310_abnormal_salivary_gland1.86653823
22MP0005646_abnormal_pituitary_gland1.85654467
23MP0001986_abnormal_taste_sensitivity1.84300650
24MP0001756_abnormal_urination1.65917804
25MP0000230_abnormal_systemic_arterial1.64871846
26MP0002102_abnormal_ear_morphology1.64441905
27MP0002822_catalepsy1.63978111
28MP0004742_abnormal_vestibular_system1.62591728
29MP0003045_fibrosis1.50734301
30MP0008872_abnormal_physiological_respon1.46423971
31MP0004510_myositis1.44316539
32MP0002234_abnormal_pharynx_morphology1.43595415
33MP0002733_abnormal_thermal_nociception1.42889970
34MP0001970_abnormal_pain_threshold1.41364968
35MP0005174_abnormal_tail_pigmentation1.40417907
36MP0000538_abnormal_urinary_bladder1.36224963
37MP0004133_heterotaxia1.35349276
38MP0000631_abnormal_neuroendocrine_gland1.34556402
39MP0008057_abnormal_DNA_replication1.34048219
40MP0009745_abnormal_behavioral_response1.33239013
41MP0001765_abnormal_ion_homeostasis1.27994243
42MP0002938_white_spotting1.26917518
43MP0002638_abnormal_pupillary_reflex1.26890697
44MP0005377_hearing/vestibular/ear_phenot1.25079961
45MP0003878_abnormal_ear_physiology1.25079961
46MP0008877_abnormal_DNA_methylation1.24478990
47MP0005645_abnormal_hypothalamus_physiol1.23740896
48MP0005386_behavior/neurological_phenoty1.22530886
49MP0004924_abnormal_behavior1.22530886
50MP0000383_abnormal_hair_follicle1.19007777
51MP0005332_abnormal_amino_acid1.17495755
52MP0006276_abnormal_autonomic_nervous1.16551190
53MP0002272_abnormal_nervous_system1.16160999
54MP0001486_abnormal_startle_reflex1.14379797
55MP0002138_abnormal_hepatobiliary_system1.14173164
56MP0006072_abnormal_retinal_apoptosis1.10232976
57MP0001502_abnormal_circadian_rhythm1.10228469
58MP0002928_abnormal_bile_duct1.09506759
59MP0002557_abnormal_social/conspecific_i1.07898624
60MP0005187_abnormal_penis_morphology1.07575442
61MP0005367_renal/urinary_system_phenotyp1.05867292
62MP0000516_abnormal_urinary_system1.05867292
63MP0000613_abnormal_salivary_gland1.04346838
64MP0003718_maternal_effect1.03538250
65MP0004085_abnormal_heartbeat1.03413171
66MP0005423_abnormal_somatic_nervous1.02812593
67MP0005220_abnormal_exocrine_pancreas1.01713156
68MP0004147_increased_porphyrin_level1.00911963
69MP0001664_abnormal_digestion0.99995464
70MP0002572_abnormal_emotion/affect_behav0.97714418
71MP0005248_abnormal_Harderian_gland0.97189115
72MP0002168_other_aberrant_phenotype0.94879162
73MP0004858_abnormal_nervous_system0.94201619
74MP0001542_abnormal_bone_strength0.93661413
75MP0010386_abnormal_urinary_bladder0.92678651
76MP0008875_abnormal_xenobiotic_pharmacok0.92568176
77MP0002837_dystrophic_cardiac_calcinosis0.91774786
78MP0000371_diluted_coat_color0.90495339
79MP0002067_abnormal_sensory_capabilities0.89977046
80MP0004019_abnormal_vitamin_homeostasis0.88995506
81MP0005389_reproductive_system_phenotype0.88397397
82MP0005636_abnormal_mineral_homeostasis0.88156879
83MP0002160_abnormal_reproductive_system0.86541474
84MP0004145_abnormal_muscle_electrophysio0.85677110
85MP0005395_other_phenotype0.85013582
86MP0001324_abnormal_eye_pigmentation0.84430998
87MP0002095_abnormal_skin_pigmentation0.82790983
88MP0001764_abnormal_homeostasis0.82409024
89MP0005595_abnormal_vascular_smooth0.81961549
90MP0009384_cardiac_valve_regurgitation0.80856026
91MP0005195_abnormal_posterior_eye0.80514279
92MP0002693_abnormal_pancreas_physiology0.79990398
93MP0000026_abnormal_inner_ear0.79371309
94MP0000427_abnormal_hair_cycle0.79055612
95MP0002909_abnormal_adrenal_gland0.78771091
96MP0002064_seizures0.77451293
97MP0002752_abnormal_somatic_nervous0.75418188
98MP0002063_abnormal_learning/memory/cond0.73495319
99MP0005083_abnormal_biliary_tract0.73442435
100MP0001666_abnormal_nutrient_absorption0.70560476

Predicted human phenotypes

RankGene SetZ-score
1Gaze-evoked nystagmus (HP:0000640)4.18014097
2Pancreatic cysts (HP:0001737)4.00503701
3True hermaphroditism (HP:0010459)3.84561253
4Genetic anticipation (HP:0003743)3.68931515
5Hypoplasia of the pons (HP:0012110)3.66874565
6Pancreatic fibrosis (HP:0100732)3.65539888
7Progressive cerebellar ataxia (HP:0002073)3.64807382
8Hyperventilation (HP:0002883)3.63634762
9Abnormality of the pons (HP:0007361)3.54542342
10Type II lissencephaly (HP:0007260)3.52560830
11Nephronophthisis (HP:0000090)3.42092400
12Abnormality of midbrain morphology (HP:0002418)3.41285391
13Molar tooth sign on MRI (HP:0002419)3.41285391
14Congenital stationary night blindness (HP:0007642)3.39441240
15Hypothermia (HP:0002045)3.34456102
16Large for gestational age (HP:0001520)3.21260526
17Abolished electroretinogram (ERG) (HP:0000550)3.19103883
18Tubular atrophy (HP:0000092)3.16897614
19Decreased circulating renin level (HP:0003351)3.01995919
20Broad-based gait (HP:0002136)2.98026126
21Aplasia/Hypoplasia of the tibia (HP:0005772)2.97823567
22Abnormality of the renal medulla (HP:0100957)2.97478553
23Cerebellar dysplasia (HP:0007033)2.97391167
24Amelogenesis imperfecta (HP:0000705)2.89786809
25Clumsiness (HP:0002312)2.89498526
26Abnormality of the renal cortex (HP:0011035)2.81207693
27Stomach cancer (HP:0012126)2.73388143
28Generalized hypopigmentation of hair (HP:0011358)2.69406462
29Cystic liver disease (HP:0006706)2.67163003
30Chronic hepatic failure (HP:0100626)2.58319161
31Attenuation of retinal blood vessels (HP:0007843)2.57915298
32Keratoconus (HP:0000563)2.54096307
33Increased corneal curvature (HP:0100692)2.54096307
34Medial flaring of the eyebrow (HP:0010747)2.53277517
35Abnormal drinking behavior (HP:0030082)2.50640806
36Polydipsia (HP:0001959)2.50640806
37Progressive inability to walk (HP:0002505)2.46152365
38Optic nerve hypoplasia (HP:0000609)2.42955789
39Inability to walk (HP:0002540)2.36955492
40Pendular nystagmus (HP:0012043)2.36898554
41Depressed nasal tip (HP:0000437)2.36795320
42Protruding tongue (HP:0010808)2.36509729
43Congenital, generalized hypertrichosis (HP:0004540)2.33671793
44Hyperglycinuria (HP:0003108)2.31305660
45Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.26500710
46Short tibia (HP:0005736)2.25601046
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.24413573
48Abnormality of alanine metabolism (HP:0010916)2.24413573
49Hyperalaninemia (HP:0003348)2.24413573
50Decreased central vision (HP:0007663)2.23898576
51Abnormal albumin level (HP:0012116)2.22703713
52Hypoalbuminemia (HP:0003073)2.22703713
53Tented upper lip vermilion (HP:0010804)2.18103345
54Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.17454121
55Fair hair (HP:0002286)2.16041001
56Tachypnea (HP:0002789)2.15944430
57Severe muscular hypotonia (HP:0006829)2.14463623
58Ketoacidosis (HP:0001993)2.14286236
59Congenital sensorineural hearing impairment (HP:0008527)2.13010062
60Abnormality of homocysteine metabolism (HP:0010919)2.11909646
61Homocystinuria (HP:0002156)2.11909646
62Furrowed tongue (HP:0000221)2.10825629
63Anencephaly (HP:0002323)2.07232674
64Abnormal rod and cone electroretinograms (HP:0008323)2.06984819
65Aplasia/Hypoplasia of the spleen (HP:0010451)2.05329376
66Abnormality of renin-angiotensin system (HP:0000847)2.03624373
67Ketosis (HP:0001946)2.02838846
68Renal cortical cysts (HP:0000803)1.98527012
69Gait imbalance (HP:0002141)1.94110332
70Male pseudohermaphroditism (HP:0000037)1.93892116
71Aplasia/Hypoplasia of the tongue (HP:0010295)1.92621410
72Lissencephaly (HP:0001339)1.92164807
73Hydroxyprolinuria (HP:0003080)1.90024143
74Abnormality of proline metabolism (HP:0010907)1.90024143
75Febrile seizures (HP:0002373)1.89996195
76Asplenia (HP:0001746)1.89957757
77Polyuria (HP:0000103)1.89047372
78Congenital primary aphakia (HP:0007707)1.88567165
79Sclerocornea (HP:0000647)1.86866402
80Bony spicule pigmentary retinopathy (HP:0007737)1.83354612
81Congenital hepatic fibrosis (HP:0002612)1.83010241
82Macular degeneration (HP:0000608)1.81389617
83Metabolic alkalosis (HP:0200114)1.80440920
84Supernumerary bones of the axial skeleton (HP:0009144)1.80173336
85Dysdiadochokinesis (HP:0002075)1.79841318
86Hemiparesis (HP:0001269)1.79475067
87Postaxial foot polydactyly (HP:0001830)1.77483939
88Neoplasm of the heart (HP:0100544)1.77481340
89Chorioretinal atrophy (HP:0000533)1.72562218
90Abnormal biliary tract physiology (HP:0012439)1.72305306
91Bile duct proliferation (HP:0001408)1.72305306
92Abnormality of the nasal septum (HP:0000419)1.71814822
93Absent speech (HP:0001344)1.70705840
94Concave nail (HP:0001598)1.69578624
95Duplicated collecting system (HP:0000081)1.69083627
96Abnormality of the renal collecting system (HP:0004742)1.68516496
97Retinitis pigmentosa (HP:0000510)1.67931938
98Nephrogenic diabetes insipidus (HP:0009806)1.65602363
99Confusion (HP:0001289)1.64264113
100Prostate neoplasm (HP:0100787)1.64089800

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.79843909
2ADRBK23.75996323
3AKT33.47636124
4BMPR1B3.01729489
5TAOK32.79800314
6ACVR1B2.26727469
7EPHA32.21961231
8STK38L2.16321046
9WNK42.08506021
10DAPK22.07819893
11SGK21.99674588
12GRK11.99618276
13NUAK11.89447660
14STK391.78270376
15MAPKAPK31.76647102
16MAPK131.74467085
17PRKD31.73298214
18WNK31.72494310
19INSRR1.68514519
20PNCK1.67453658
21MAP2K61.58350818
22MKNK21.58153794
23SGK2231.57794680
24SGK4941.57794680
25NLK1.53010333
26MAPK151.50711750
27TNIK1.46558925
28OXSR11.45787517
29TXK1.42537277
30TLK11.39810083
31MAP3K41.33666563
32CASK1.23558017
33PINK11.19839770
34PAK31.16914524
35ZAK1.16738735
36TGFBR11.15089719
37MAP4K21.04706590
38PRKCE1.00707667
39TNK20.98173580
40LATS10.95698516
41ADRBK10.95209549
42CAMK1G0.93142133
43CHUK0.92997175
44CAMK1D0.92943168
45PRKAA20.89469940
46SGK30.87745180
47MYLK0.85905987
48MAP2K70.83202709
49ERBB20.80726584
50MAPKAPK50.76645855
51CSNK1A1L0.74433942
52VRK10.72996047
53CSNK1G10.71423607
54STK30.69449901
55STK380.68969683
56IRAK10.67394525
57WNK10.66258183
58EPHB10.63614998
59FER0.63220902
60PHKG20.63164564
61PHKG10.63164564
62NTRK30.59126335
63TRPM70.57153024
64EEF2K0.57023206
65IKBKB0.56007059
66PIK3CA0.55699222
67YES10.55494407
68PRKAA10.54603198
69TAOK10.53353350
70MKNK10.52693865
71PTK2B0.51599766
72SGK10.50738536
73PRKCG0.50426069
74DYRK20.49361664
75PRKCZ0.48147546
76PKN20.46472688
77ITK0.44630614
78BRSK20.43524244
79TAF10.42644830
80CSNK1G30.42113939
81PRKCH0.41620118
82CSNK1A10.40120589
83BCR0.38012217
84RPS6KA50.38002041
85CSNK1G20.37683186
86STK110.36641062
87PRKCI0.32512052
88CAMKK20.31889442
89DMPK0.31519639
90TRIM280.30802905
91PRKCQ0.30096841
92AKT10.29043013
93GSK3A0.28884289
94PRKACA0.28874058
95GRK70.28631867
96MARK10.27674498
97EPHB20.27536016
98CAMK10.26412824
99PTK60.26007482
100BCKDK0.25288962

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006503.11208832
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.66543088
3Linoleic acid metabolism_Homo sapiens_hsa005912.50320720
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.31174524
5Phototransduction_Homo sapiens_hsa047442.28532657
6Nitrogen metabolism_Homo sapiens_hsa009102.18296663
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.16002378
8Histidine metabolism_Homo sapiens_hsa003402.10265305
9Tryptophan metabolism_Homo sapiens_hsa003802.03814539
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02616055
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.01873890
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90667888
13Selenocompound metabolism_Homo sapiens_hsa004501.84367173
14beta-Alanine metabolism_Homo sapiens_hsa004101.84298955
15ABC transporters_Homo sapiens_hsa020101.83272025
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.83006077
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.77900230
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.73329939
19Retinol metabolism_Homo sapiens_hsa008301.72108426
20Circadian rhythm_Homo sapiens_hsa047101.69672311
21Propanoate metabolism_Homo sapiens_hsa006401.69443777
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68505070
23Vitamin digestion and absorption_Homo sapiens_hsa049771.65732088
24Caffeine metabolism_Homo sapiens_hsa002321.64542613
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.64078905
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.63975650
27Mineral absorption_Homo sapiens_hsa049781.56260291
28Chemical carcinogenesis_Homo sapiens_hsa052041.55285051
29Ether lipid metabolism_Homo sapiens_hsa005651.54848238
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.47793166
31Peroxisome_Homo sapiens_hsa041461.47385274
32Nicotine addiction_Homo sapiens_hsa050331.42822613
33Arachidonic acid metabolism_Homo sapiens_hsa005901.39764308
34Insulin secretion_Homo sapiens_hsa049111.31890626
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30594079
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30235384
37Ovarian steroidogenesis_Homo sapiens_hsa049131.28573875
38Protein export_Homo sapiens_hsa030601.27835435
39Salivary secretion_Homo sapiens_hsa049701.24506389
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20602016
41Taste transduction_Homo sapiens_hsa047421.13185258
42Steroid biosynthesis_Homo sapiens_hsa001001.11409306
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08813475
44Serotonergic synapse_Homo sapiens_hsa047261.08018275
45RNA polymerase_Homo sapiens_hsa030201.05905089
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.03575084
47Cocaine addiction_Homo sapiens_hsa050301.00823899
48* Olfactory transduction_Homo sapiens_hsa047400.90732905
49Morphine addiction_Homo sapiens_hsa050320.87621417
50Calcium signaling pathway_Homo sapiens_hsa040200.84351663
51Fatty acid metabolism_Homo sapiens_hsa012120.84218698
52Amphetamine addiction_Homo sapiens_hsa050310.84127444
53Basal transcription factors_Homo sapiens_hsa030220.83327263
54Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83154085
55Regulation of autophagy_Homo sapiens_hsa041400.83062814
56Glutamatergic synapse_Homo sapiens_hsa047240.80886170
57Fatty acid degradation_Homo sapiens_hsa000710.79566146
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74077710
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73637747
60Circadian entrainment_Homo sapiens_hsa047130.73145357
61One carbon pool by folate_Homo sapiens_hsa006700.73084665
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.72136046
63Bile secretion_Homo sapiens_hsa049760.72064401
64cAMP signaling pathway_Homo sapiens_hsa040240.70473403
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70391035
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69322409
67Renin secretion_Homo sapiens_hsa049240.66831112
68Fanconi anemia pathway_Homo sapiens_hsa034600.64317378
69Oxidative phosphorylation_Homo sapiens_hsa001900.64054524
70Homologous recombination_Homo sapiens_hsa034400.61759367
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59981653
72Dorso-ventral axis formation_Homo sapiens_hsa043200.58557642
73GABAergic synapse_Homo sapiens_hsa047270.57844048
74Phenylalanine metabolism_Homo sapiens_hsa003600.56415765
75Lysine degradation_Homo sapiens_hsa003100.55901202
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53708636
77Metabolic pathways_Homo sapiens_hsa011000.51941013
78Dopaminergic synapse_Homo sapiens_hsa047280.48672893
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47387815
80Insulin resistance_Homo sapiens_hsa049310.46481561
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46418751
82Arginine and proline metabolism_Homo sapiens_hsa003300.45051731
83Fatty acid biosynthesis_Homo sapiens_hsa000610.44748134
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43607482
85Basal cell carcinoma_Homo sapiens_hsa052170.42692059
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42011783
87Thyroid hormone synthesis_Homo sapiens_hsa049180.41950337
88Tyrosine metabolism_Homo sapiens_hsa003500.41540493
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38930659
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.38624961
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.37581897
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37534606
93Hedgehog signaling pathway_Homo sapiens_hsa043400.36685474
94Purine metabolism_Homo sapiens_hsa002300.35832747
95Oxytocin signaling pathway_Homo sapiens_hsa049210.35332110
96Cholinergic synapse_Homo sapiens_hsa047250.34883553
97Long-term depression_Homo sapiens_hsa047300.32899805
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32309546
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.31429919
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30109917

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